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Soy allergy

Thomas Holzhauser, Annegret Franke, Regina Treudler, Anett Schmiedeknecht, Stefanie Randow, Wolf-Meinhard Becker, Jonas Lidholm, Stefan Vieths, Jan-Christoph Simon
SCOPE: The BASALIT clinical trial (EudraCT 2009-011737-27) investigated efficacy of birch allergen immunotherapy on lowest observed adverse effect levels (LOAEL) after soy food challenge in patients with birch-associated and Gly m 4 allergen-mediated soy allergy. Thus, consistently stable Gly m 4 levels were required in standardised challenge meals. METHODS AND RESULTS: Soy meal included soy protein isolate (SPI, 88% total protein). A Gly m 4-specific ELISA was developed and validated...
October 17, 2016: Molecular Nutrition & Food Research
Willem S Lexmond, Jeremy A Goettel, Jonathan J Lyons, Justin Jacobse, Marion M Deken, Monica G Lawrence, Thomas H DiMaggio, Daniel Kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste C Nelson, Nina Jones, Kelly D Stone, Fabio Candotti, Edmond H H M Rings, Adrian J Thrasher, Joshua D Milner, Scott B Snapper, Edda Fiebiger
In addition to the infectious consequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly understood exaggerated immune responses that result in autoimmunity and elevated levels of serum IgE. Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens. WASP-deficient animals displayed an adjuvant-free IgE-sensitization to chow antigens that was most pronounced for wheat and soy and occurred under specific pathogen-free as well as germ-free housing conditions...
October 3, 2016: Journal of Clinical Investigation
David A Hill, Robert W Grundmeier, Gita Ram, Jonathan M Spergel
BACKGROUND: The rates of childhood allergic conditions are changing, prompting the need for continued surveillance. Examination of healthcare provider-based diagnosis data is an important and lacking methodology needed to complement existing studies that rely on participant reporting. METHODS: Utilizing our care network of 1,050,061 urban and sub-urban children, we defined two retrospective cohorts: (1) a closed birth cohort of 29,662 children and (2) a cross-sectional cohort of 333,200 children...
2016: BMC Pediatrics
Felix Husslik, Jasmin Nürnberg, Christian Seutter von Loetzen, Timo Mews, Barbara K Ballmer-Weber, Jörg Kleine-Tebbe, Regina Treudler, Jan-Christoph Simon, Stefanie Randow, Elke Völker, Andreas Reuter, Paul Rösch, Stefan Vieths, Thomas Holzhauser, Dirk Schiller
BACKGROUND: Birch pollen-related soy allergy is mediated by Gly m 4. Conformational IgE epitopes of Gly m 4 are unknown. OBJECTIVE: To identify the IgE epitope profile of Gly m 4 in subjects with birch pollen-related soy allergy utilizing an epitope library presented by Gly m 4-type model proteins. METHODS: Sera from patients with (n = 26) and without (n = 19) allergy to soy as determined by oral provocation tests were studied...
August 17, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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No abstract text is available yet for this article.
August 2016: Journal of Pediatric Gastroenterology and Nutrition
Enrica Pessione, Simona Cirrincione
Lactic acid bacteria (LAB) can produce a huge amount of bioactive compounds. Since their elective habitat is food, especially dairy but also vegetal food, it is frequent to find bioactive molecules in fermented products. Sometimes these compounds can have adverse effects on human health such as biogenic amines (tyramine and histamine), causing allergies, hypertensive crises, and headache. However, some LAB products also display benefits for the consumers. In the present review article, the main nitrogen compounds produced by LAB are considered...
2016: Frontiers in Microbiology
Silvia Salvatore, Yvan Vandenplas
Hydrolyzed proteins are used worldwide in the therapeutic management of infants with allergic manifestations and have long been proposed as a dietetic measure to prevent allergy in at risk infants. The degree and method of hydrolysis, protein source and non-nitrogen components characterize different hydrolyzed formulas (HFs) and may determine clinical efficacy, tolerance and nutritional effects. Cow's milk (CM)-based HFs are classified as extensively (eHF) or partially HF (pHF) based on the percentage of small peptides...
2016: Nestlé Nutrition Institute Workshop Series
M Ponce, S C Diesner, Z Szépfalusi, T Eiwegger
IgE-mediated reactions to food allergens are the most common cause of anaphylaxis in childhood. Although allergies to cow's milk, egg, or soy proteins, in contrast to peanut and tree nut allergens, resolve within the first 6 years of life in up to 60% due to natural tolerance development, this process is not well understood. At present, there is no cure or treatment for food allergy that would result in an induction of tolerance to the symptom-eliciting food. Avoidance, providing an emergency plan and education, is the standard of treatment...
October 2016: Allergy
Nedeljko Radlović, Zoran Leković, Vladimir Radlović, Dusica Simić, Dragana Ristić, Biljana Vuletić
Food allergy represents a highly up-to-date and continually increasing problem of modern man. Although being present in all ages, it most often occures in children aged up to three years. Sensitization most often occurs by a direct way, but it is also possible to be caused by mother's milk, and even transplacentally. Predisposition of inadequate immune response to antigen stimulation, reaginic or nonreaginic, is of non-selective character so that food allergy is often multiple and to a high rate associated with inhalation and/or contact hypersensitivity...
January 2016: Srpski Arhiv za Celokupno Lekarstvo
Pooja Mehta, Shikha Sundaram, Glenn T Furuta, Zhaoxing Pan, Dan Atkins, Scott Markowitz
Propofol is a safe, well-tolerated anesthetic that is labeled as contraindicated in patients with egg or soy allergy. This contraindication has become increasingly problematic given the rising incidence of food allergy and eosinophilic esophagitis (EoE). To address this issue, we studied practice patterns of propofol use for esophagogastroduodenoscopies (EGD) in children with EoE and food allergies at our institution. A retrospective observational study of 1365 EGDs from January 2013 to June 2014 was performed...
June 8, 2016: Journal of Pediatric Gastroenterology and Nutrition
Margitta Worm, Josefine Grünhagen, Sabine Dölle
Anaphylactic reactions due to food occur in the context of food allergy and, together with venom and drugs, are the most frequent elicitors of severe allergic reactions. In small children the most frequent elicitors of severe allergic reactions according to data from the anaphylaxis registry are hen's egg and milk, whereas in school children peanut and hazelnut are frequent elicitors of allergic reactions. Other frequent elicitors of anaphylactic reactions in childhood are wheat and soy. In adults the most frequent elicitors of severe allergic reactions due to food, based on data from the anaphylaxis registry, are wheat, soy, celery, shellfish and hazelnut...
July 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Youngshin Han, Jing Lin, Ludmilla Bardina, Galina A Grishina, Chaeyoon Lee, Won Hee Seo, Hugh A Sampson
Ara h 2, a peanut 2S albumin, is associated with severe allergic reactions, but a homologous protein, soybean 2S albumin, is not recognized as an important allergen. Structural difference between these proteins might explain this clinical discrepancy. Therefore, we mapped sequential epitopes and compared the structure of Ara h 2, Soy Al 1, and Soy Al 3 (Gly m 8) to confirm whether structural differences account for the discrepancy in clinical responses to these two proteins. Commercially synthesized peptides covering the full length of Ara h 2 and two soybean 2S albumins were analyzed by peptide microarray...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
C Richard, E Beaudouin, D A Moneret-Vautrin, C Kohler, V M Nguyen-Grosjean, S Jacquenet
The growing worldwide prevalence of food allergies is drawing attention to the risk of allergenic proteins found in intravenous medicinal products, particularly anaesthetics. Propofol induced anaphylaxis has been described. The presence of soybean oil and egg lecithins in the lipid emulsion highlights their suspected responsibility in certain cases. We report a case of anaphylaxis to propofol in an adult patient without food allergy to soy, but with a latent sensitization to soy. An IgE-dependent allergy to propofol was established by a basophil activation test...
May 2016: European Annals of Allergy and Clinical Immunology
R Asero, G Mistrello, S Amato, D Villalta
A case of adult onset severe soy allergy is discussed. The allergen protein involved did not correspond to those presently detectable by commercial diagnostic means, but was not identified, possibly due to the insufficient level of specific IgE. Fresh foods and commercial food extracts remain an invaluable tool to support the diagnosis of food allergy, both in-vivo and in-vitro.
May 2016: European Annals of Allergy and Clinical Immunology
Guo-Dong Hao, Yi-Wu Zheng, Zhi-Xiang Wang, Xing-Ai Kong, Zhi-Jing Song, Xu-Xin Lai, Michael D Spangfort
BACKGROUND: Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. METHODS: Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. Specific immunoglobulin E (IgE) against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100...
May 2016: Journal of Zhejiang University. Science. B
John J Riascos, Sandra M Weissinger, Arthur K Weissinger, Michael Kulis, A Wesley Burks, Laurent Pons
Soybean is a common allergenic food; thus, a comprehensive characterization of all the proteins that cause allergy is crucial to the development of effective diagnostic and immunotherapeutic strategies. A cDNA library was constructed from seven stages of developing soybean seeds to investigate candidate allergens. We searched the library for cDNAs encoding a seed-specific biotinylated protein (SBP) based on its allergenicity in boiled lentils. A full-length cDNA clone was retrieved and expressed as a 75.6-kDa His-tagged recombinant protein (rSBP) in Escherichia coli...
May 18, 2016: Journal of Agricultural and Food Chemistry
Laxmi Yeruva, Nicole E Spencer, Manish K Saraf, Leah Hennings, Anne K Bowlin, Mario A Cleves, Kelly Mercer, Sree V Chintapalli, Kartik Shankar, Roger G Rank, Thomas M Badger, Martin J J Ronis
BACKGROUND: Breastfeeding is associated with a variety of positive health outcomes in children and is recommended exclusively for the first 6 months of life; however, 50-70 % of infants in the US are formula-fed. To test the hypothesis that immune system development and function in neonates and infants are significantly influenced by diet, 2-day old piglets were fed soy or milk formula (n = 6/group/gender) until day 21 and compared to a sow-fed group (n = 6/gender). METHODS: Histomorphometric analyses of ileum, jejunum and Peyer's patches were carried out, to determine the inflammation status, mRNA and protein expression of pro-inflammatory, anti-inflammatory and growth-related chemokines and cytokines...
2016: BMC Gastroenterology
Luca Bucchini, Antonella Guzzon, Roland Poms, Hamide Senyuva
As part of a European Union-funded project (FP7) developing 'Integrated approaches to food allergen and allergy management', a database was constructed based on publicly available information on food allergen recalls in Europe, North America, Hong Kong, Australia and New Zealand. Over 2000 entries were made into the database. The database covers a 4-year period from 2011 to 2014 and each entry is categorised into food type (two different classifications), identified allergen and cause where indicated by the authorities...
May 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Kristina Warstedt, Catrin Furuhjelm, Karin Fälth-Magnusson, Malin Fagerås, Karel Duchén
AIM: We previously reported a protective effect of maternal omega-3 fatty acid supplements on the development of immunoglobulin E (IgE)-associated disease in infancy. This study assessed omega-3 long-chain polyunsaturated fatty acids (LCPUFA) in maternal milk in relation to omega-3 LCPUFA supplementation and the development of allergic disease in their infants. METHODS: This study randomised 95 pregnant women at risk of having an allergic infant, to daily supplements of 2...
November 2016: Acta Paediatrica
M Kamalakannan, L M Chang, G Grishina, H A Sampson, M Masilamani
BACKGROUND: DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for the development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. OBJECTIVE: We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods...
August 2016: Allergy
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