keyword
https://read.qxmd.com/read/38283727/-jcem-case-reports-a-remarkable-first-year
#1
EDITORIAL
William F Young
No abstract text is available yet for this article.
February 2024: JCEM Case Rep
https://read.qxmd.com/read/37908252/-jcem-case-reports-a-new-journal-for-clinicians
#2
EDITORIAL
William F Young
No abstract text is available yet for this article.
January 2023: JCEM Case Rep
https://read.qxmd.com/read/33590316/evaluation-and-management-of-atypical-femoral-fractures-an-update-of-current-knowledge
#3
REVIEW
O Pearce, T Edwards, K Al-Hourani, M Kelly, A Riddick
Atypical femoral fractures are often attributed to the use of anti-resorptive medications such as bisphosphonates (BP). Whilst they have proven effects on fragility fracture prevention, clinical and laboratory evidence is evolving linking BP-related suppression of bone remodelling to the development of atypical stress-related sub-trochanteric fractures (Shane et al. in JBMR 29:1-23, 2014; Odvina et al. in JCEM 90:1294-301, 2005; Durchschlag et al. in JBMR 21(10):1581-1590, 2006; Donnelly et al. in JBMR 27:672-678, 2012; Mashiba et al...
July 2021: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/32215150/history-of-the-canadian-medical-education-journalhistorique-du-journal-canadien-de-l-%C3%A3-ducation-m%C3%A3-dicale-jc%C3%A3-m
#4
JOURNAL ARTICLE
Claudio Violato, Marcel F D'Eon
No abstract text is available yet for this article.
March 2020: Canadian Medical Education Journal
https://read.qxmd.com/read/31922566/which-drug-next-sequential-therapy-for-osteoporosis
#5
COMMENT
Barbara P Lukert
The proliferation of drugs with unique modes of action for treating osteoporosis has been most welcome. Fear of complications, even though rare, associated with long-term bisphosphonates (BPs) changed prescribing patterns. The BPs are stored in bone for years. Drugs not stored in bone; for example, abaloparatide, teriparatide, denosumab, and romosozumab have expanded our armamentarium for treating osteoporosis but have brought new challenges. Bone accrued during treatment with the last 3 drugs, and perhaps abaloparatide, is lost rapidly after their withdrawal due to rebound increase in bone resorption...
March 1, 2020: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31677602/jcem-editor-s-swan-song-2015-2019
#6
JOURNAL ARTICLE
R Paul Robertson
No abstract text is available yet for this article.
December 1, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31574000/paget-s-disease-of-bone-updates-for-clinicians
#7
REVIEW
Emory Hsu
PURPOSE OF REVIEW: To provide clinicians an overview to the diagnosis, treatment, and management of Paget's disease, including recent guideline recommendations, with comparison of the Endocrine Society Clinical Practice Guideline (JCEM 2014) with the new Clinical Guideline review endorsed by the International Osteoporosis Foundation, the American Society of Bone and Mineral Research, the European Calcified Tissues Society, and the United Kingdom Bone Research Society (JBMR 2019). RECENT FINDINGS: Radionuclide bone scans are recommended for assessing the extent of Paget's disease...
December 2019: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/27955748/influence-of-bioactive-sulfated-polysaccharide-protein-complexes-on-hepatocarcinogenesis-angiogenesis-and-immunomodulatory-activities
#8
JOURNAL ARTICLE
Azza A Matloub, Hadeer A Aglan, Sahar Salah Mohamed El Souda, Mona Elsayed Aboutabl, Amany Sayed Maghraby, Hanaa H Ahmed
OBJECTIVE: To explore the in vivo anticancer, anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens (JCEM) and Pterocladia capillacea (PCEM) as well as hot aqueous extract of Enteromorpha intestinalis (EHEM) against hepatocellular carcinoma rat model (HCC) and to study their chemical composition. METHODS: The sugars and amino acids composition of the bioactive polysaccharides of JCEM, PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer, respectively...
December 2016: Asian Pacific Journal of Tropical Medicine
https://read.qxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#9
JOURNAL ARTICLE
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://read.qxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#10
JOURNAL ARTICLE
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://read.qxmd.com/read/26908106/perspective-on-the-genetics-and-diagnosis-of-congenital-hyperinsulinism-disorders
#11
REVIEW
Charles A Stanley
CONTEXT: Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in children. The risk of permanent brain injury in infants with HI continues to be as high as 25-50% due to delays in diagnosis and inadequate treatment. Congenital HI has been described since the birth of the JCEM under various terms, including "idiopathic hypoglycemia of infancy," "leucine-sensitive hypoglycemia," or "nesidioblastosis." EVIDENCE ACQUISITION: In the past 20 years, it has become apparent that HI is caused by genetic defects in the pathways that regulate pancreatic β-cell insulin secretion...
March 2016: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/26840100/pr%C3%A3-cis-for-jcem-no-empty-promises
#12
EDITORIAL
R Paul Robertson
No abstract text is available yet for this article.
February 2016: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/26513003/reducing-the-risk-of-ohss-by-gnrh-agonist-triggering
#13
COMMENT
Robert F Casper
CONTEXT: Overstimulation of follicle development in assisted reproductive technology cycles can lead to the development of life-threatening ovarian hyperstimulation syndrome (OHSS). There is evidence that administration of GnRH agonist as the trigger for final follicular maturation, instead of the usual human chorionic gonadotropin trigger, will reduce the risk of OHSS by shortening the duration of luteal stimulation, lowering estrogen levels by inducing luteolysis and reducing the secretion of vascular endothelial growth factor (VEGF)...
December 2015: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/25787534/-185-pos-reprometa-and-happy-pregnancy-study-combining-the-retrospective-and-prospective-approach-for-discovery-and-development-of-new-biomarkers-for-pregnancy-complications
#14
JOURNAL ARTICLE
Kristiina Rull, Pille Vaas, Ele Hanson, Pille Teesalu, Tiina Rebane, Maris Laan
OBJECTIVES: (1) To collect both retrospective and prospective study cohorts of pregnant women with clinical data and biological material (blood, urine, placenta) from variety of pregnancy complications (pregnancy loss, preeclampsia, gestational diabetes, fetal growth disorders) for development of new biomarkers. (2) To translate the discovery findings from retrospective study cohort containing the selected and well-characterized clinical phenotypes into clinical practice using longitudinal sample collection...
January 2015: Pregnancy Hypertension
https://read.qxmd.com/read/25559531/continuing-the-jcem-mission-with-its-new-editorial-team
#15
EDITORIAL
R Paul Robertson
No abstract text is available yet for this article.
January 2015: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/23463657/challenges-to-the-measurement-of-estradiol-an-endocrine-society-position-statement
#16
REVIEW
William Rosner, Susan E Hankinson, Patrick M Sluss, Hubert W Vesper, Margaret E Wierman
OBJECTIVE: The objective of the study was to evaluate the current state of clinical assays for estradiol in the context of their applications. PARTICIPANTS: The participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. EVIDENCE: Data were gathered from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), and the clinical and laboratory experience of the participants...
April 2013: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/22869843/management-of-thyroid-dysfunction-during-pregnancy-and-postpartum-an-endocrine-society-clinical-practice-guideline
#17
REVIEW
Leslie De Groot, Marcos Abalovich, Erik K Alexander, Nobuyuki Amino, Linda Barbour, Rhoda H Cobin, Creswell J Eastman, John H Lazarus, Dominique Luton, Susan J Mandel, Jorge Mestman, Joanne Rovet, Scott Sullivan
OBJECTIVE: The aim was to update the guidelines for the management of thyroid dysfunction during pregnancy and postpartum published previously in 2007. A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at https://jcem.endojournals.org). EVIDENCE: This evidence-based guideline was developed according to the U.S. Preventive Service Task Force, grading items level A, B, C, D, or I, on the basis of the strength of evidence and magnitude of net benefit (benefits minus harms) as well as the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence...
August 2012: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/16350723/-diagnostic-and-therapeutic-difficulties-in-men-1-syndrome
#18
REVIEW
Janusz Krassowski
MEN 1 syndrome (Multiple Endocrine Neoplasia type 1) is a rare endocrine disorder characterized by the association of tumors in several endocrine glands, mainly in parathyroids, gut and pituitary. At our institution in the years 1982-2004 we have followed 26 patients with MEN 1 syndrome belonging to 19 families. The diagnosis of MEN 1 was based on Gubbio Consensus (JCEM 86: 5658-5671, 2001). Mean age at the diagnosis of MEN 1 was 35 years. Primary hyperparathyroidism was the most frequent pathology, which was diagnosed in 25 of 26 patients (96%)...
2005: Endokrynologia Polska
https://read.qxmd.com/read/9623591/transforming-growth-factor-beta1-in-the-human-endometrium-cyclic-variation-increased-expression-by-estradiol-and-progesterone-and-regulation-of-plasminogen-activators-and-plasminogen-activator-inhibitor-1
#19
JOURNAL ARTICLE
B Casslén, T Sandberg, B Gustavsson, R Willén, M Nilbert
The purpose of this study was to identify cyclic variations and hormonal regulation of endometrial transforming growth factor beta1 (TGFbeta1) mRNA. Regulation of the plasminogen-activating system was also examined, since it is involved in activation of latent TGFbetas. We measured TGFbeta1 mRNA in 51 normal endometrial samples by Northern blot and densitometric scanning of autoradiograms. Each value was related to the corresponding beta-actin value to allow quantitative evaluation. TGFbeta1 mRNA was higher in the mid and late secretory and menstrual phases than in the earlier parts of the cycle...
June 1998: Biology of Reproduction
https://read.qxmd.com/read/9441365/-treatment-of-amiodarone-induced-hyperthyroidism-corticosteroids-or-potassium-perchlorate-what-value-do-interleukin-6-levels-have
#20
JOURNAL ARTICLE
R Martin-Du Pan, O Konfino, M Zimmermann
We report 11 cases of amiodarone-induced hyperthyroidism. We tried to classify them into 2 groups, according to Bartelena et al. (JCEM 81: 2930, 1996). The serum level of interleukin-6 (IL-6) was measured in 7 patients by an immunoenzymometric assay. In type I (cases 1-3) the thyroid was abnormal (goiter, Graves' disease) but IL-6 levels were normal. These cases were successfully managed by the combined use of thionamide drugs (carbimazol or propylthioruacil = PTU) and potassium perchlorate. In type II (case 4), the thyroid seemed to be normal but the serum level of IL-6 was increased, possibly due to a destructive thyroiditis...
October 1997: Revue Médicale de la Suisse Romande
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