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https://www.readbyqxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#1
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#2
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26908106/perspective-on-the-genetics-and-diagnosis-of-congenital-hyperinsulinism-disorders
#3
REVIEW
Charles A Stanley
CONTEXT: Congenital hyperinsulinism (HI) is the most common cause of hypoglycemia in children. The risk of permanent brain injury in infants with HI continues to be as high as 25-50% due to delays in diagnosis and inadequate treatment. Congenital HI has been described since the birth of the JCEM under various terms, including "idiopathic hypoglycemia of infancy," "leucine-sensitive hypoglycemia," or "nesidioblastosis." EVIDENCE ACQUISITION: In the past 20 years, it has become apparent that HI is caused by genetic defects in the pathways that regulate pancreatic β-cell insulin secretion...
March 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26840100/pr%C3%A3-cis-for-jcem-no-empty-promises
#4
EDITORIAL
R Paul Robertson
No abstract text is available yet for this article.
February 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26513003/reducing-the-risk-of-ohss-by-gnrh-agonist-triggering
#5
COMMENT
Robert F Casper
CONTEXT: Overstimulation of follicle development in assisted reproductive technology cycles can lead to the development of life-threatening ovarian hyperstimulation syndrome (OHSS). There is evidence that administration of GnRH agonist as the trigger for final follicular maturation, instead of the usual human chorionic gonadotropin trigger, will reduce the risk of OHSS by shortening the duration of luteal stimulation, lowering estrogen levels by inducing luteolysis and reducing the secretion of vascular endothelial growth factor (VEGF)...
December 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25787534/-185-pos-reprometa-and-happy-pregnancy-study-combining-the-retrospective-and-prospective-approach-for-discovery-and-development-of-new-biomarkers-for-pregnancy-complications
#6
Kristiina Rull, Pille Vaas, Ele Hanson, Pille Teesalu, Tiina Rebane, Maris Laan
OBJECTIVES: (1) To collect both retrospective and prospective study cohorts of pregnant women with clinical data and biological material (blood, urine, placenta) from variety of pregnancy complications (pregnancy loss, preeclampsia, gestational diabetes, fetal growth disorders) for development of new biomarkers. (2) To translate the discovery findings from retrospective study cohort containing the selected and well-characterized clinical phenotypes into clinical practice using longitudinal sample collection...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25559531/continuing-the-jcem-mission-with-its-new-editorial-team
#7
EDITORIAL
R Paul Robertson
No abstract text is available yet for this article.
January 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23463657/challenges-to-the-measurement-of-estradiol-an-endocrine-society-position-statement
#8
REVIEW
William Rosner, Susan E Hankinson, Patrick M Sluss, Hubert W Vesper, Margaret E Wierman
OBJECTIVE: The objective of the study was to evaluate the current state of clinical assays for estradiol in the context of their applications. PARTICIPANTS: The participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. EVIDENCE: Data were gathered from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), and the clinical and laboratory experience of the participants...
April 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/22869843/management-of-thyroid-dysfunction-during-pregnancy-and-postpartum-an-endocrine-society-clinical-practice-guideline
#9
REVIEW
Leslie De Groot, Marcos Abalovich, Erik K Alexander, Nobuyuki Amino, Linda Barbour, Rhoda H Cobin, Creswell J Eastman, John H Lazarus, Dominique Luton, Susan J Mandel, Jorge Mestman, Joanne Rovet, Scott Sullivan
OBJECTIVE: The aim was to update the guidelines for the management of thyroid dysfunction during pregnancy and postpartum published previously in 2007. A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at http://jcem.endojournals.org). EVIDENCE: This evidence-based guideline was developed according to the U.S. Preventive Service Task Force, grading items level A, B, C, D, or I, on the basis of the strength of evidence and magnitude of net benefit (benefits minus harms) as well as the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence...
August 2012: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/16350723/-diagnostic-and-therapeutic-difficulties-in-men-1-syndrome
#10
REVIEW
Janusz Krassowski
MEN 1 syndrome (Multiple Endocrine Neoplasia type 1) is a rare endocrine disorder characterized by the association of tumors in several endocrine glands, mainly in parathyroids, gut and pituitary. At our institution in the years 1982-2004 we have followed 26 patients with MEN 1 syndrome belonging to 19 families. The diagnosis of MEN 1 was based on Gubbio Consensus (JCEM 86: 5658-5671, 2001). Mean age at the diagnosis of MEN 1 was 35 years. Primary hyperparathyroidism was the most frequent pathology, which was diagnosed in 25 of 26 patients (96%)...
May 2005: Endokrynologia Polska
https://www.readbyqxmd.com/read/9623591/transforming-growth-factor-beta1-in-the-human-endometrium-cyclic-variation-increased-expression-by-estradiol-and-progesterone-and-regulation-of-plasminogen-activators-and-plasminogen-activator-inhibitor-1
#11
B Casslén, T Sandberg, B Gustavsson, R Willén, M Nilbert
The purpose of this study was to identify cyclic variations and hormonal regulation of endometrial transforming growth factor beta1 (TGFbeta1) mRNA. Regulation of the plasminogen-activating system was also examined, since it is involved in activation of latent TGFbetas. We measured TGFbeta1 mRNA in 51 normal endometrial samples by Northern blot and densitometric scanning of autoradiograms. Each value was related to the corresponding beta-actin value to allow quantitative evaluation. TGFbeta1 mRNA was higher in the mid and late secretory and menstrual phases than in the earlier parts of the cycle...
June 1998: Biology of Reproduction
https://www.readbyqxmd.com/read/9441365/-treatment-of-amiodarone-induced-hyperthyroidism-corticosteroids-or-potassium-perchlorate-what-value-do-interleukin-6-levels-have
#12
R Martin-Du Pan, O Konfino, M Zimmermann
We report 11 cases of amiodarone-induced hyperthyroidism. We tried to classify them into 2 groups, according to Bartelena et al. (JCEM 81: 2930, 1996). The serum level of interleukin-6 (IL-6) was measured in 7 patients by an immunoenzymometric assay. In type I (cases 1-3) the thyroid was abnormal (goiter, Graves' disease) but IL-6 levels were normal. These cases were successfully managed by the combined use of thionamide drugs (carbimazol or propylthioruacil = PTU) and potassium perchlorate. In type II (case 4), the thyroid seemed to be normal but the serum level of IL-6 was increased, possibly due to a destructive thyroiditis...
October 1997: Revue Médicale de la Suisse Romande
https://www.readbyqxmd.com/read/8964590/sex-hormone-binding-protein-hyperinsulinemia-insulin-resistance-and-noninsulin-dependent-diabetes
#13
REVIEW
S M Haffner
Possible data complicating sex hormones, especially testosterone, in the etiology of cardiovascular disease and noninsulin-dependent diabetes mellitus (NIDDM) comes from the much higher rates of cardiovascular disease in men than in women. Pharmacological administration of anabolic steroids to both men and women increases glucose and insulin concentrations and also insulin resistance. In vivo assessment of sex hormones and binding proteins in both premenopausal and postmenopausal women has suggested that increased free testosterone and decreased sex hormone-binding globulin (SHBG) is associated with higher glucose and insulin concentrations...
1996: Hormone Research
https://www.readbyqxmd.com/read/7698680/-kinetic-study-of-pulsatility-of-gonadotropin-and-testosterone-secretion-in-normospermic-fertile-and-infertile-men-with-idiopathic-oligo-asthenozoospermia
#14
COMPARATIVE STUDY
E Chavarría, A Reyes, A Carrera, G Aguilera, A Rosado, J D Veldhuis
Idiopathic oligo-asthenozoospermia is among the most frequent causes of male infertility and has a not very well understood etiopathogenesis. To obtain valuable information about the role of some endocrine factors in the etiology of this kind of infertility, information that is not easy obtain by the traditional analytical methods, we applied some recently proposed mathematical algorithms to analyze with more exactitude the importance of the secretory pulses of three hormones, luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T)...
February 1995: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/2407572/-a-case-of-glucocorticoid-responsive-hyperaldosteronism-follow-up-study-for-21-years-comparison-with-cases-of-17-alpha-hydroxylase-deficiency-in-japan
#15
REVIEW
H Murase, N Yamakita, K Yasuda, N Noritake, L B Mercado-Asis, K Takeuchi, O Murakami, K Abe, K Yoshinaga, K Miura
A study of the pathophysiology in our previously reported case of glucocorticoid-responsive hyperaldosteronism (Case E.H., 17 yrs old, female; JCEM, 28: 1807, 1968), who had undergone a long-term successful treatment for 21 yrs of daily 0.5 mg dexamethasone (Dex), suggested again that the patient had 17 alpha-hydroxylase deficiency (17-OH-D) in the adrenal with minimum enzyme deficiency in the ovary. When Case E.H. was injected with zinc-ACTH for 3 days with daily 0.5 mg Dex administration, plasma levels of 17-deoxy-steroids were moderately or dramatically increased, but those of 17 alpha-hydroxy-steroids (17-OH-steroids) responded poorly or not at all...
January 20, 1990: Nihon Naibunpi Gakkai Zasshi
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