Nan Chiang, Xavier de la Rosa, Stephania Libreros, Hui Pan, Jonathan M Dreyfuss, Charles N Serhan
The recently elucidated proresolving conjugates in tissue regeneration (CTR) maresin-CTR (MCTR), protectin-CTR (PCTR), and resolvin-CTR (RCTR), termed cysteinyl-specialized proresolving mediators (cys-SPMs) each promotes regeneration, controls infection, and accelerates resolution of inflammation. Here, we sought evidence for cys-SPM activation of primordial pathways in planaria ( Dugesia japonica ) regeneration that might link resolution of inflammation and regeneration. On surgical resection, planaria regeneration was enhanced with MCTR3, PCTR3, or RCTR3 (10 nM), each used for RNA sequencing...
March 9, 2021: Proceedings of the National Academy of Sciences of the United States of America