Wenwen Cheng, Cifeng Cai, Yifan Xu, Xueqi Xiao, Tiantian Shi, Yueling Liao, Xiaoyi Wang, Shasha Chen, Meiliang Zhou, Zhiyong Liao
Chronic hyperglycaemia is a devastating factor that causes diabetes-induced damage to the retina and kidney. However, the precise mechanism by which hyperglycaemia drives apoptotic cell death is incompletely known. Herein, we found that FOXD1, a FOX family transcription factor specifically expressed in the retina and kidney, regulated the transcription of BCL-2, a master regulator of cell survival. Intriguingly, the protein level of FOXD1, which responded negatively to hyperglycaemic conditions, was controlled by the TRIM21-mediated K48-linked polyubiquitination and subsequent proteasomal degradation...
December 13, 2023: Cell Death & Disease