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https://www.readbyqxmd.com/read/29929139/exposure-therapy-for-youth-with-anxiety-utilization-rates-and-predictors-of-implementation-in-a-sample-of-practicing-clinicians-from-across-the-united-states
#1
Adam M Reid, Andrew G Guzick, Alyka Glor Fernandez, Brett Deacon, Joseph P H McNamara, Gary R Geffken, Ryan McCarty, Catherine W Striley
Exposure therapy is a highly effective, evidence-based treatment technique for children and adolescents with anxiety disorders. Regardless, therapists in the community are reported to use exposure relatively rarely compared with other approaches. The goal of the present study was to identify how practicing clinicians treat youth with anxiety disorders across the United States and what factors contribute to their use of exposure therapy. Recruited from public directories, 257 private practice therapists who treat anxious youth were surveyed...
June 18, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29928938/sensory-sensitivity-mediates-the-relationship-between-anxiety-and-picky-eating-in-children-adolescents-ages-8-17-and-in-college-undergraduates-a-replication-and-age-upward-extension
#2
Hana F Zickgraf, Anjeli Elkins
This study explores the relationships among anxiety, sensitivity to sensory stimuli, and picky eating (PE). An earlier study in 95 children ages 5-10 found that sensory sensitivity fully mediated the relationship between anxiety and picky eating. We replicated this finding in a sample of 158 children, ages 8-17, and in 813 young adult college students. As in the previous child sample, the relationship between anxiety and picky eating appears to be mediated by sensory sensitivity. This relationship extends into adolescence and young adulthood and holds even in a sample of children with obsessive-compulsive-spectrum and anxiety disorders...
June 18, 2018: Appetite
https://www.readbyqxmd.com/read/29928152/novel-human-genome-variants-associated-with-alcohol-use-disorders-identified-in-a-lithuanian-cohort
#3
Karolis Baronas, Tautvydas Rančelis, Aidas Pranculis, Ingrida Domarkienė, Laima Ambrozaitytė, Vaidutis Kučinskas
Background: Alcohol use disorder (AUD) is a chronic relapsing brain disease characterized by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using (1). Abusive alcohol consumption directly affects a person's physical and psychological health and social life. The World Health Organization has shown that Lithuania is a leading country in pure alcohol consumption in the world (2). The aim of this study is to find novel genome variants that are associated with the AUD in the Lithuanian cohort...
2018: Acta Medica Lituanica
https://www.readbyqxmd.com/read/29927677/8-f2-isoprostane-thioredoxin-and-thioredoxin-reductase-levels-in-children-with-obsessive-compulsive-disorder
#4
Ayhan Bilgiç, Rukiye Çolak Sivri, İbrahim Kılınç
PURPOSE: Accumulating data demonstrate that oxidative stress may play a crucial role in obsessive-compulsive disorder (OCD). This study aimed to investigate the role of 8-F2-isoprostane, thioredoxin (Trx), and thioredoxin reductase (TrxR) in children with OCD. MATERIALS AND METHODS: Thirty-three drug-free children with OCD and 35 healthy controls were included in this study. The severity of OCD symptoms was assessed via the Children's Yale Brown Obsessive-Compulsive Scale...
June 21, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29927297/examining-the-dsm-5-alternative-model-of-personality-disorders-operationalization-of-obsessive-compulsive-personality-disorder-in-a-mental-health-sample
#5
Jacqueline Liggett, Martin Sellbom
The current study evaluated the continuity between the diagnostic operationalizations of obsessive-compulsive personality disorder (OCPD) in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition, both as traditionally operationalized and from the perspective of the alternative model of personality disorders. Using both self-report and informant measures, the study had the following four aims: (a) to examine the extent to which self-report and informant data correspond, (b) to investigate whether both self-report and informant measures of the alternative model of OCPD can predict traditional OCPD, (c) to determine if any traits additional to those proposed in the alternative model of OCPD can predict traditional OCPD, and (d) to investigate whether a measure of OCPD-specific impairment is better at predicting traditional OCPD than are measures of general impairment in personality functioning...
June 21, 2018: Personality Disorders
https://www.readbyqxmd.com/read/29927272/condom-use-self-efficacy-as-a-mediator-between-syndemics-and-condomless-sex-in-men-who-have-sex-with-men-msm
#6
Steven A Safren, Aaron J Blashill, Jasper S Lee, Conall O'Cleirigh, Julia Tomassili, Katie B Biello, Matthew J Mimiaga, Kenneth H Mayer
OBJECTIVE: Among men who have sex with men (MSM), HIV sexual risk and poor self-care behavior is associated with syndemics, or co-occurring psychosocial problems. Though prior research has demonstrated an additive total effect of syndemics on HIV risk behavior and infection, mostly within cross-sectional designs, it is possible that these associations are not direct but rather that syndemics disrupt relevant individual-level mediating psychological variables. One of the more common individual-level psychological variables that predicts health behavior generally, and HIV risk behavior specifically, is self-efficacy...
June 21, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29925858/downregulation-of-the-neuronal-opioid-gene-expression-concomitantly-with-neuronal-decline-in-dorsolateral-prefrontal-cortex-of-human-alcoholics
#7
Igor Bazov, Daniil Sarkisyan, Olga Kononenko, Hiroyuki Watanabe, Victor M Karpyak, Tatiana Yakovleva, Georgy Bakalkin
Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impairment of learning and memory, while KOR antagonists block excessive, compulsive-like drug and alcohol self-administration in animal models. In human brain, the DYN/KOR system may undergo adaptive changes, which along with neuronal loss, may contribute to alcohol-associated cognitive deficit...
June 20, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29925684/intranasal-carbetocin-reduces-hyperphagia-in-individuals-with-prader-willi-syndrome
#8
Elisabeth M Dykens, Jennifer Miller, Moris Angulo, Elizabeth Roof, Michael Reidy, Hind T Hatoum, Richard Willey, Guy Bolton, Paul Korner
BACKGROUND: Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder of life-threatening hyperphagia, obesity, intellectual deficits, compulsivity, and other behavioral problems. The efficacy and safety of i.n. carbetocin, an oxytocin analog, was evaluated in a prospective, randomized, double-blinded trial in adolescents with PWS. METHODS: Eligible patients aged 10-18 years with genetically confirmed PWS were randomized (1:1) to i.n. carbetocin or placebo 3 times daily for 14 days...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29920848/does-neuropsychological-performance-in-ocd-relate-to-different-symptoms-a-meta-analysis-comparing-the-symmetry-and-obsessing-dimensions
#9
REVIEW
Laura B Bragdon, Brandon E Gibb, Meredith E Coles
BACKGROUND: Investigations of neuropsychological functioning in obsessive-compulsive disorder (OCD) have produced mixed results for deficits in executive functioning (EF), attention, and memory. One potential explanation for varied findings may relate to the heterogeneity of symptom presentations, and different clinical or neurobiological characteristics may underlie these different symptoms. METHODS: We investigated differences in neuropsychological functioning between two symptoms groups, obsessing/checking (O/C) and symmetry/ordering (S/O), based on data suggesting an association with different motivations: harm avoidance and incompleteness, respectively...
June 19, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29920483/salivary-inflammatory-markers-in-trichotillomania-a-pilot-study
#10
Jon E Grant, Samuel R Chamberlain
BACKGROUND: Immune dysregulation has been hypothesized to be important in the development and pathophysiology of compulsive disorders such as obsessive compulsive disorder (OCD), which has a high comorbid overlap with trichotillomania (both are OC-related disorders). The role of inflammation in the pathophysiology of trichotillomania has garnered little research to date. METHODS: Individuals with trichotillomania provided saliva sample for analysis of inflammatory cytokines...
June 19, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29915338/heroin-abuse-results-in-shifted-rna-expression-to-neurodegenerative-diseases-and-attenuation-of-tnf%C3%AE-signaling-pathway
#11
Mei Zhu, Yu Xu, Huawei Wang, Zongwen Shen, Zhenrong Xie, Fengrong Chen, Yunhong Gao, Xin Chen, Ying Zhang, Qiang Wu, Xuejun Li, Juehua Yu, Huayou Luo, Kunhua Wang
Repeated administration of heroin results in the induction of physical dependence, which is characterized as a behavioral state of compulsive drug seeking and a high rate of relapse even after periods of abstinence. However, few studies have been dedicated to characterization of the long-term alterations in heroin-dependent patients (HDPs). Herein, we examined the peripheral blood from 810 HDPs versus 500 healthy controls (HCs) according to the inclusion criteria. Compared with the control group, significant decreases of albumin, triglyceride, and total cholesterol levels were identified in HDPs (P < 0...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915200/subthalamic-theta-activity-a-novel-human-subcortical-biomarker-for-obsessive-compulsive-disorder
#12
Pnina Rappel, Odeya Marmor, Atira S Bick, David Arkadir, Eduard Linetsky, Anna Castrioto, Idit Tamir, Sara A Freedman, Tomer Mevorach, Moran Gilad, Hagai Bergman, Zvi Israel, Renana Eitan
Obsessive-compulsive disorder (OCD) is a common and serious psychiatric disorder. Although subthalamic nucleus deep brain stimulation (DBS) has been studied as a treatment for OCD patients the underlying mechanism of this treatment and the optimal method of stimulation are unknown. To study the neural basis of subthalamic nucleus DBS in OCD patients we used a novel, implantable DBS system with long-term local field potential sensing capability. We focus our analysis on two patients with OCD who experienced severe treatment-resistant symptoms and were implanted with subthalamic nucleus DBS systems...
June 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29913754/psychiatric-axis-i-and-personality-axis-ii-disorders-in-patients-with-burning-mouth-syndrome-or-atypical-facial-pain
#13
Tero Taiminen, Laura Kuusalo, Laura Lehtinen, Heli Forssell, Nora Hagelberg, Olli Tenovuo, Sinikka Luutonen, Antti Pertovaara, Satu Jääskeläinen
Background and aims Burning mouth syndrome (BMS) and atypical facial pain (AFP) are often persistent idiopathic pain conditions that mainly affect middle-aged and elderly women. They have both been associated with various psychiatric disorders. This study examined current and lifetime prevalence of psychiatric axis I (symptom-based) and II (personality) disorders in patients with chronic idiopathic orofacial pain, and investigated the temporal relationship of psychiatric disorders and the onset of orofacial pain...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913376/compulsive-buying-in-paris-psychology-students-assessment-of-dsm-5-personality-trait-domains
#14
David Duroy, Olivier Sabbagh, Ariane Baudel, Michel Lejoyeux
Compulsive buying is associated with significant psychiatric comorbidity, such as personality disorders. Few studies have focused on the dimensional model of personality disorders in compulsive buying. We aimed to assess the eventual presence of personality dysfunctions in compulsive buying according to the Diagnostic and Statistical Manual of Mental Disorder, 5th edition (DSM-5) dimensional conception of personality disorders. We screened online compulsive buying (QABB), characterized purchasing behavior and explored DSM-5 personality trait domains (Personality Inventory for DSM-5-Brief Form [PID-5-BF]) in 233 Paris psychology students using an online self-reporting questionnaire...
June 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29913341/impulse-control-disorders-in-parkinson-s-disease-patients-with-rls-a-cross-sectional-study
#15
Ana Marques, Michela Figorilli, Bruno Pereira, Philippe Derost, Berengere Debilly, Patricia Beudin, Tiphaine Vidal, Franck Durif, Maria Livia Fantini
BACKGROUND: Although dopamine replacement therapy is the main risk factor for the occurrence of Impulse Control Disorders (ICDs) in Parkinson's disease (PD), non-pharmacological risk factors for have also been identified in that population and sleep disorders could be part of them. Our objective is to determine whether Restless Legs Syndrome (RLS), that has been associated with more impulsive choices in general population regardless of dopaminergic therapy, could be associated with a specific psycho-behavioral profile and ICDs in PD...
March 1, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29913087/revisiting-the-role-of-impulsivity-and-compulsivity-in-problematic-sexual-behaviors
#16
Beáta Bőthe, István Tóth-Király, Marc N Potenza, Mark D Griffiths, Gábor Orosz, Zsolt Demetrovics
Impulsivity and compulsivity are transdiagnostic features associated with clinically relevant aspects of psychiatric disorders, including addictions. However, little research has investigated how impulsivity and compulsivity relate to hypersexuality and problematic pornography use. Thus, the aims of the present study were to investigate (a) self-reported impulsivity and compulsivity with respect to hypersexuality and problematic pornography use and (b) the similarities and possible differences between hypersexuality and problematic pornography use in these domains...
June 18, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29912203/an-invasive-method-for-the-activation-of-the-mouse-dentate-gyrus-by-high-frequency-stimulation
#17
Zhe Zhao, Haitao Wu
Electrical high-frequency stimulation (HFS), using implanted electrodes targeting various brain regions, has been proven as an effective treatment for various neurological and psychiatric disorders. HFS in the deep region of the brain, also named deep-brain stimulation (DBS), is becoming increasingly important in clinical trials. Recent progress in the field of high-frequency DBS (HF-DBS) surgery has begun to spread the possibility of utilizing this invasive technique to other situations, such as treatment for major depression disorder (MDD), obsessive-compulsive disorder (OCD), and so on...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29908912/oral-n-acetylcysteine-in-the-treatment-of-obsessive-compulsive-disorder-a-systematic-review-of-the-clinical-evidence
#18
REVIEW
José Paulo Couto, Ricardo Moreira
Obsessive-compulsive disorder (OCD) is characterized by the presence of obsessions and/or compulsions. It is a leading cause of morbidity worldwide, as it can interfere with all aspects of life. Despite the adequate treatment trials, half of patients preserve residual or impairing symptoms and selective serotonin reuptake inhibitors (SSRIs) are not free from adverse side effects. This work aims to systematically review the current evidence available concerning the efficacy of N-acetylcysteine (NAC) in the treatment of OCD...
June 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29908232/the-association-of-spinophilin-with-disks-large-associated-protein-3-sapap3-is-regulated-by-metabotropic-glutamate-receptor-mglur-5
#19
Cameron W Morris, Darryl S Watkins, Asma B Salek, Michael C Edler, Anthony J Baucum
Spinophilin is the most abundant protein phosphatase 1 targeting protein in the postsynaptic density of dendritic spines. Spinophilin associates with myriad synaptic proteins to regulate normal synaptic communication; however, the full complement of spinophilin interacting proteins and mechanisms regulating spinophilin interactions are unclear. Here we validate an association between spinophilin and the scaffolding protein, disks large-associated protein 3 (SAP90/PSD-95 associated protein 3; SAPAP3). Loss of SAPAP3 leads to obsessive-compulsive disorder (OCD)-like behaviors due to alterations in metabotropic glutamate receptor (mGluR) signaling...
June 13, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29907520/why-do-young-hispanic-women-take-sexual-risks-psychological-and-cultural-factors-for-hiv-prevention
#20
Cristina Giménez-García, Estefanía Ruiz-Palomino, María Dolores Gil-Llario, Rafael Ballester-Arnal, Claudia Castañeiras
Young Hispanic women have been particularly affected by HIV. For this reason, we analyzed the influence of cognitive factors, dispositional variables, and gender culture on the HIV risks of two groups of Hispanic women. Young Argentinian and Spanish women (N = 342) completed the AIDS Prevention Questionnaire, the Spanish version of the Sexual Compulsivity Scale, and the Spanish version of the Sexual Sensation Seeking Scale in order to evaluate knowledge of HIV transmission, HIV, and condom use; self-efficacy; safe-sex intention and safe sex; as well as Sexual Sensation Seeking and Sexual Compulsivity traits...
June 4, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
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