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https://www.readbyqxmd.com/read/27911342/impulsive-and-compulsive-behaviors-in%C3%A2-parkinson-disease-the-norwegian-parkwest-study
#1
Aleksander H Erga, Guido Alves, Jan Petter Larsen, Ole Bj Rn Tysnes, Kenn Freddy Pedersen
BACKGROUND: Impulsive and compulsive behaviors (ICBs) are frequent in Parkinson's disease (PD), but data from population-based cohorts is lacking. OBJECTIVES: To determine the frequency and associated demographic, clinical, neuropsychiatric and cognitive features of ICBs in a population-based PD cohort. METHODS: This cross-sectional study included 125 patients with PD and 159 age- and gender-matched normal controls recruited from the Norwegian ParkWest study...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27909991/the-role-of-orexins-hypocretins-in-alcohol-use-and-abuse
#2
Leigh C Walker, Andrew J Lawrence
Addiction is a chronic relapsing disorder characterized by compulsive drug seeking and drug taking despite negative consequences. Alcohol abuse and addiction have major social and economic consequences and cause significant morbidity and mortality worldwide. Currently available therapeutics are inadequate, outlining the need for alternative treatments. Detailed knowledge of the neurocircuitry and brain chemistry responsible for aberrant behavior patterns should enable the development of novel pharmacotherapies to treat addiction...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27909683/fronto-striatal-glutamate-in-children-with-tourette-s-disorder-and-attention-deficit-hyperactivity-disorder
#3
Jilly Naaijen, Natalie J Forde, David J Lythgoe, Sophie E A Akkermans, Thaira J C Openneer, Andrea Dietrich, Marcel P Zwiers, Pieter J Hoekstra, Jan K Buitelaar
OBJECTIVE: Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies. METHOD: We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD n = 15, ADHD n = 39, TD + ADHD n = 29, and healthy controls n = 53) as an in vivo method of evaluating glutamate concentrations in the fronto-striatal circuit...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27909449/association-between-dsm-iv-anxiety-disorders-and-suicidal-behaviors-in-a-community-sample-of-south-korean-adults
#4
Seong-Jin Cho, Jin Pyo Hong, Jun-Young Lee, Jeong Soo Im, Kyoung-Sae Na, Jee Eun Park, Maeng Je Cho
OBJECTIVE: There are conflicting reports about whether individual anxiety disorders are independently associated with suicidal ideation and suicide attempts. We examined whether anxiety disorders are related to suicidal ideation and suicide attempts in a community sample of South Korean adults. METHODS: In-person interviews based on the South Korean version of the Composite International Diagnostic Interview were conducted to diagnose mental disorders. Multivariate logistic regression analysis was performed to examine whether anxiety disorders were associated with suicidal ideation and suicide attempts...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27907082/gender-differences-in-compulsive-buying-disorder-assessment-of-demographic-and-psychiatric-co-morbidities
#5
Cristiana Nicoli de Mattos, Hyoun S Kim, Marinalva G Requião, Renata F Marasaldi, Tatiana Z Filomensky, David C Hodgins, Hermano Tavares
Compulsive buying is a common disorder found worldwide. Although recent research has shed light into the prevalence, etiology and clinical correlates of compulsive buying disorder, less is known about gender differences. To address this empirical gap, we assessed potential gender differences in demographic and psychiatric co-morbidities in a sample of 171 compulsive buyers (20 men and 151 women) voluntarily seeking treatment in São Paulo, Brazil. A structured clinical interview confirmed the diagnosis of compulsive buying...
2016: PloS One
https://www.readbyqxmd.com/read/27905905/prevalence-and-co-occurrence-of-compulsive-buying-problematic-internet-and-mobile-phone-use-in-college-students-in-yantai-china-relevance-of-self-traits
#6
Zhaocai Jiang, Mingyan Shi
BACKGROUND: Until now, most research in the prevalence of compulsive buying (CB) has been developed from samples in western developed countries, this study aimed to estimate the prevalence and co-morbidities of CB, problematic Internet use (PIU) and problematic mobile phone use (PMPU) in college students in Yantai, China. Moreover, based on the lack of research focusing on differences between CB and addiction, we will explore whether CB and PIU/PMPU individuals are characterized by the same self-traits (i...
December 1, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27903327/auditory-vigilance-and-working-memory-in-youth-at-familial-risk-for-schizophrenia-or-affective-psychosis-in-the-harvard-adolescent-family-high-risk-study
#7
Larry J Seidman, Andrea Pousada-Casal, Silvia Scala, Eric C Meyer, William S Stone, Heidi W Thermenos, Elena Molokotos, Jessica Agnew-Blais, Ming T Tsuang, Stephen V Faraone
BACKGROUND: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin's subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27903255/epigenetic-evidence-for-involvement-of-the-oxytocin-receptor-gene-in-obsessive-compulsive-disorder
#8
Carolina Cappi, Juliana Belo Diniz, Guaraci L Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H Marques, Marcelo Q Hoexter, Carlos A Pereira, Euripedes Constantino Miguel, Helena Brentani
BACKGROUND: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors...
November 30, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27903196/the-impact-of-cobalt-60-source-age-on-biologically-effective-dose-in-high-dose-functional-gamma-knife-radiosurgery
#9
Benjamin H Kann, James B Yu, John M Stahl, James E Bond, Christopher Loiselle, Veronica L Chiang, Ranjit S Bindra, Jason L Gerrard, David J Carlson
OBJECTIVE Functional Gamma Knife radiosurgery (GKRS) procedures have been increasingly used for treating patients with tremor, trigeminal neuralgia (TN), and refractory obsessive-compulsive disorder. Although its rates of toxicity are low, GKRS has been associated with some, if low, risks for serious sequelae, including hemiparesis and even death. Anecdotal reports have suggested that even with a standardized prescription dose, rates of functional GKRS toxicity increase after replacement of an old cobalt-60 source with a new source...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27901519/predictors-of-comorbid-obsessive-compulsive-disorder-and-skin-picking-disorder-in-trichotillomania
#10
Nancy J Keuthen, Erin E Curley, Jeremiah M Scharf, Douglas W Woods, Christine Lochner, Dan J Stein, Esther S Tung, Erica Greenberg, S Evelyn Stewart, Sarah A Redden, Jon E Grant
BACKGROUND: Trichotillomania (TTM), obsessive-compulsive disorder (OCD), and skin-picking disorder (SPD) frequently occur together and share overlapping phenomenology, pathophysiology, and possible genetic underpinnings. This study sought to identify factors that predict OCD and SPD in hair pullers. METHODS: Five hundred fifty-five adult female hair pullers were recruited from specialty clinics and assessed using standardized, semi-structured interviews and self-reports...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27901303/diagnostic-masking-and-overshadowing-in-intellectual-disability-how-structured-evaluation-helps
#11
Harshini Manohar, Karthick Subramanian, Preeti Kandasamy, Venkatalakshmi Penchilaiya, Anandbabu Arun
PROBLEM: Comorbid psychiatric diagnoses tend to be underdiagnosed in patients with intellectual disability. Diagnosing anxiety disorders in such patients can pose challenges, in particular with regard to obsessive and compulsive disorder (OCD). METHODS: We present the case of an adolescent diagnosed with intellectual disability with poor expressive language skills who presented with nonspecific mood and behavioral symptoms, not improving with routine clinical evaluations and treatment...
November 30, 2016: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/27901245/transcranial-direct-current-stimulation-for-treatment-resistant-obsessive-compulsive-disorder-report-on-two-cases-and-proposal-for-a-randomized-sham-controlled-trial
#12
Renata de Melo Felipe da Silva, André Russowsky Brunoni, Eurípedes Constantino Miguel, Roseli Gedanke Shavitt
CONTEXT AND OBJECTIVE: Neuromodulation techniques for treating obsessive-compulsive disorder (OCD) have expanded through greater understanding of the brain circuits involved in this disorder. Transcranial direct current stimulation (tDCS), a non-invasive technique, has been studied as an alternative for treatment-resistant OCD. We describe the design of a clinical trial using tDCS for OCD and report on the outcomes from two patients with primary OCD who were resistant to cognitive-behavioral therapy and to selective serotonin reuptake inhibitors, and who received tDCS in an open manner during the training phase for the study procedures...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27900437/bdnf-and-ltp-ltd-like-plasticity-of-the-primary-motor-cortex-in-gilles-de-la-tourette-syndrome
#13
L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini, F Cardona, G Defazio, A Berardelli
Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects...
November 30, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27899165/cognitive-dysfunction-in-body-dysmorphic-disorder-new-implications-for-nosological-systems-and-neurobiological-models
#14
Kiri Jefferies-Sewell, Samuel R Chamberlain, Naomi A Fineberg, Keith R Laws
: Introduction Body dysmorphic disorder (BDD) is a debilitating disorder, characterized by obsessions and compulsions relating specifically to perceived appearance, and which has been newly classified within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Obsessive-Compulsive and Related Disorders grouping. Until now, little research has been conducted into the cognitive profile of this disorder. METHODS: Participants with BDD (n=12) and participants without BDD (n=16) were tested using a computerized neurocognitive battery investigating attentional set-shifting (Intra/Extra Dimensional Set Shift Task), decision-making (Cambridge Gamble Task), motor response-inhibition (Stop-Signal Reaction Time Task), and affective processing (Affective Go-No Go Task)...
November 30, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27894107/effect-of-gonadal-hormones-on-neurotransmitters-implicated-in-the-pathophysiology-of-obsessive-compulsive-disorder-a-critical-review
#15
Marta Karpinski, Gabriella Francesca Mattina, Meir Steiner
No abstract text is available yet for this article.
November 28, 2016: Neuroendocrinology
https://www.readbyqxmd.com/read/27894106/prader-willi-syndrome-due-to-an-unbalanced-de-novo-translocation-t-15-19-q12-p13-3
#16
Vy Dang, Abhilasha Surampalli, Ann M Manzardo, Stephanie Youn, Merlin G Butler, June-Anne Gold, Virginia E Kimonis
Prader-Willi syndrome (PWS) is a complex, multisystem genetic disorder characterized by endocrine, neurologic, and behavioral abnormalities. We report the first case of an unbalanced de novo reciprocal translocation of chromosomes 15 and 19, 45,XY,-15,der(19)t(15;19)(q12;p13.3), resulting in monosomy for the PWS critical chromosome region. Our patient had several typical features of PWS including infantile hypotonia, a poor suck and feeding difficulties, tantrums, skin picking, compulsions, small hands and feet, and food seeking, but not hypopigmentation, a micropenis, cryptorchidism or obesity as common findings seen in PWS at the time of examination at 6 years of age...
November 29, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27893229/measurement-invariance-of-the-yale-food-addiction-scale-2-0-across-gender-and-racial-groups
#17
Meagan M Carr, Pelin D Catak, Megan C Pejsa-Reitz, Karen K Saules, Ashley N Gearhardt
Food addiction describes a psychological and behavioral eating pattern that is similar to the experience of those compulsively taking drugs of abuse. Recent developments related to food addiction, including the development and validation of an updated measure (Yale Food Addiction Scale 2.0; Gearhardt, Corbin, & Brownell, 2016), have increased knowledge as to the prevalence and associated correlates of food addiction. However, less is known about the phenomenological experience of food addiction in diverse samples or how the existing measure of food addiction performs in heterogeneous samples...
November 28, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27891299/tourette-syndrome-and-comorbid-neuropsychiatric-conditions
#18
REVIEW
Ashutosh Kumar, William Trescher, Debra Byler
Tourette syndrome is a neuropsychiatric condition characterized by both motor and phonic tics over a period of at least 1 year with the onset in childhood or adolescence. Apart from the tics, most of the patients with Tourette syndrome have associated neuropsychiatric comorbidities consisting of attention deficit hyperactivity disorder, obsessive compulsive disorder, rage attacks, sleep issues, depression, and migraine. Patients may also have physical complications directly from violent motor tics which can rarely include cervical myelopathy, arterial dissection, and stroke...
2016: Current Developmental Disorders Reports
https://www.readbyqxmd.com/read/27891112/deep-brain-stimulation-for-tourette-s-syndrome-the-case-for-targeting-the-thalamic-centromedian-parafascicular-complex
#19
REVIEW
Paola Testini, Hoon-Ki Min, Asif Bashir, Kendall H Lee
Tourette's syndrome (TS) is a neurologic condition characterized by both motor and phonic tics and is typically associated with psychiatric comorbidities, including obsessive-compulsive disorder/behavior and attention-deficit hyperactivity disorder, and can be psychologically and socially debilitating. It is considered a disorder of the cortico-striato-thalamo-cortical circuitry, as suggested by pathophysiology studies and therapeutic options. Among these, deep brain stimulation (DBS) of the centromedian-parafascicular nucleus (CM-Pf) of the thalamus is emerging as a valuable treatment modality for patients affected by severe, treatment-resistant TS...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27891104/hoarding-symptoms-are-not-exclusive-to-hoarders
#20
Caterina Novara, Gioia Bottesi, Stella Dorz, Ezio Sanavio
Hoarding disorder (HD) was originally conceptualized as a subcategory of obsessive compulsive disorder (OCD), and numerous studies have in fact focused exclusively on investigating the comorbidity between OCD and HD. Hoarding behavior can nevertheless also be found in other clinical populations and in particular in patients with eating disorders (ED), anxiety disorders (AD), major depression (MD), and psychotic disorders (PD). The current study was carried out with the aim of investigating, using a validated instrument such as the Saving Inventory-Revised (SI-R), the presence of HD symptoms in patients diagnosed with ED, AD, MD, and PD...
2016: Frontiers in Psychology
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