keyword
MENU ▼
Read by QxMD icon Read
search

Severe traumatic brain injury

keyword
https://www.readbyqxmd.com/read/29927963/the-currency-completeness-and-quality-of-systematic-reviews-of-acute-management-of-moderate-to-severe-traumatic-brain-injury-a-comprehensive-evidence-map
#1
Anneliese Synnot, Peter Bragge, Carole Lunny, David Menon, Ornella Clavisi, Loyal Pattuwage, Victor Volovici, Stefania Mondello, Maryse C Cnossen, Emma Donoghue, Russell L Gruen, Andrew Maas
OBJECTIVE: To appraise the currency, completeness and quality of evidence from systematic reviews (SRs) of acute management of moderate to severe traumatic brain injury (TBI). METHODS: We conducted comprehensive searches to March 2016 for published, English-language SRs and RCTs of acute management of moderate to severe TBI. Systematic reviews and RCTs were grouped under 12 broad intervention categories. For each review, we mapped the included and non-included RCTs, noting the reasons why RCTs were omitted...
2018: PloS One
https://www.readbyqxmd.com/read/29927671/impact-of-age-on-acute-post-tbi-neuropathology-in-mice-expressing-humanized-tau-a-chronic-effects-of-neurotrauma-consortium-study
#2
Benoit Mouzon, Nicole Saltiel, Scott Ferguson, Joseph Ojo, Carlyn Lungmus, Cillian Lynch, Moustafa Algamal, Alexander Morin, Benjamin Carper, Gayle Bieler, Elliott J Mufson, William Stewart, Michael Mullan, Fiona Crawford
OBJECTIVES: We hypothesized that polypathology is more severe in older than younger mice during the acute phase following repetitive mild traumatic brain injury (r-mTBI). METHODS: Young and aged male and female mice transgenic for human tau (hTau) were exposed to r-mTBI or a sham procedure. Twenty-four hours post-last injury, mouse brain tissue was immunostained for alterations in astrogliosis, microgliosis, tau pathology, and axonal injury. RESULTS: Quantitative analysis revealed a greater percent distribution of glial fibrillary acid protein and Iba-1 reactivity in the brains of all mice exposed to r-mTBI compared to sham controls...
June 21, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29927429/-modern-diagnostics-and-treatment-of-posttraumatic-hydrocephalus
#3
Ya A Latyshev, A D Kravchuk, L B Likhterman, N E Zakharova, O S Zaytsev, A G Gavrilov, V A Okhlopkov, A A Potapov
One of the frequent consequences of severe traumatic brain injury is posttraumatic hydrocephalus that not only hampers the processes of consciousness recovery, rehabilitation, and social adaptation of patients but also is the cause of disability. Pathological processes underlying the clinical picture of posttraumatic hydrocephalus and the relationship between CSF circulation disorders and structural changes in the brain substance have not been adequately studied. Of particular importance are patients in the chronic vegetative or minimally conscious state, recovery from which is blocked by posttraumatic hydrocephalus...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29927420/-autoregulation-of-cerebral-blood-flow-in-severe-diffuse-axonal-brain-injury-the-role-of-neuroanatomical-factors
#4
E V Aleksandrova, A V Oshorov, A A Sychev, A A Polupan, N E Zakharova, K K Kryukova, A I Batalov, I A Savin, A D Kravchuk, A A Potapov
Autoregulation of cerebral blood flow (ACBF) is a system of mechanisms for maintaining stable adequate perfusion of the brain despite changes in systemic arterial pressure. In recent years, new data on the numerous metabolic and systemic mechanisms of cerebral blood flow regulation have been obtained, but the role of neurogenic regulation has not yet been fully understood and, therefore, not considered in clinical practice. AIM: The study aim was to assess the effect of anatomical injuries to deep brain structures on the extent and duration of ACBF abnormalities in a model of severe diffuse axonal injury (DAI)...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29926814/role-of-brain-derived-neurotrophic-factor-during-the-regenerative-response-after-traumatic-brain-injury-in-adult-zebrafish
#5
REVIEW
Pietro Cacialli, Antonio Palladino, Carla Lucini
Several mammalian animal models of traumatic brain injury have been used, mostly rodents. However, reparative mechanisms in mammalian brain are very limited, and newly formed neurons do not survive for long time. The brain of adult zebrafish, a teleost fish widely used as vertebrate model, possesses high regenerative properties after injury due to the presence of numerous stem cells niches. The ventricular lining of the zebrafish dorsal telencephalon is the most studied neuronal stem cell niche because its dorso-lateral zone is considered the equivalent to the hippocampus of mammals which contains one of the two constitutive neurogenic niches of mammals...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29916303/controlled-cortical-impact-severity-results-in-graded-cellular-tissue-and-functional-responses-in-a-piglet-traumatic-brain-injury-model
#6
Emily W Baker, Holly A Kinder, Jessica M Hutcheson, Kylee Jo J Duberstein, Simon R Platt, Elizabeth W Howerth, Franklin D West
A number of preclinical rodent models have been developed in an effort to recapitulate injury mechanisms and identify potential therapeutics for traumatic brain injury (TBI), which is a major cause of death and long-term disability in the United States. However, the lack of restorative treatments for TBI has led to considerable criticism of current preclinical therapeutic development strategies, namely the translatability of widely-used rodent models to human patients. The use of large animal models, such as the pig, with more comparable brain anatomy and physiology to humans may enhance the translational capacity of current preclinical animal models...
June 19, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29914560/predictive-factors-of-intracranial-bleeding-in-head-trauma-patients-receiving-antiplatelet-therapy-admitted-to-an-emergency-department
#7
Farès Moustafa, Jean Roubin, Bruno Pereira, Alain Barres, Jennifer Saint-Denis, Christophe Perrier, Marine Mondet, Frederic Dutheil, Jeannot Schmidt
BACKGROUND: In head trauma cases involving antiplatelet agent treatment, the French Society of Emergency Medicine recommends performing computed tomography (CT) scans to detect brain lesions, 90% of which are normal. The value of CT is still debatable given the scarce number of studies and controversial results. METHODS: We used the RATED registry (Registry of patient with Antithrombotic agents admitted to an Emergency Department, NCT02706080) to assess factors of cerebral bleeding related to antiplatelet agents following head trauma...
June 19, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29913089/deficits-in-saccades-and-smooth-pursuit-eye-movements-in-adults-with-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#8
Revathy Mani, Lisa Asper, Sieu K Khuu
PURPOSE: To conduct a review of literature and quantify the effect that traumatic brain injury (TBI) has on oculomotor functions (OM). METHODS: A systematic review and meta-analysis was conducted from papers that objectively measured saccades and smooth-pursuit eye movements in mild and severe TBI. RESULTS: The overall impact of TBI on OM functions was moderate and significant with an effect size of 0.42 from 181 OM case-control comparisons...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29911576/symptoms-disabilities-and-life-satisfaction-five-years-after-whiplash-injuries
#9
Johan Styrke, Peter Sojka, Ulf Björnstig, Britt-Marie Stålnacke
Background Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain injury (MTBI)/concussion. In cases of MTBI, the severity and number of symptoms have been suggested to have a diagnostic value...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909586/fractal-dimension-brain-morphometry-a-novel-approach-to-quantify-white-matter-in-traumatic-brain-injury
#10
Venkateswaran Rajagopalan, Abhijit Das, Luduan Zhang, Frank Hillary, Glenn R Wylie, Guang H Yue
Traumatic brain injury (TBI) is the main cause of disability in people younger than 35 in the United States. The mechanisms of TBI are complex resulting in both focal and diffuse brain damage. Fractal dimension (FD) is a measure that can characterize morphometric complexity and variability of brain structure especially white matter (WM) structure and may provide novel insights into the injuries evident following TBI. FD-based brain morphometry may provide information on WM structural changes after TBI that is more sensitive to subtle structural changes post injury compared to conventional MRI measurements...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29909182/diffuse-axonal-injury-dai-in-moderate-to-severe-head-injured-patients-pure-dai-vs-non-pure-dai
#11
Moinay Kim, Jae Sung Ahn, Wonhyoung Park, Suk Kyung Hong, Sang Ryong Jeon, Sung Woo Roh, Seungjoo Lee
OBJECTIVE: Diffuse axonal injury (DAI) is known to be associated with poor outcome. DAI often associates with other intracranial injuries but their distinct features have not been established. In this retrospective cohort study, we compared clinical outcomes between pure and non-pure DAI patients. PATIENTS AND METHODS: Total of 1047 traumatic brain injury (TBI) patients visited our institute between 2011 and 2017. Age ranged between 15-85 years old and Glasgow coma scale (GCS) score less than 13 were included...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29907235/rapid-valproic-acid-induced-modulation-of-the-traumatic-proteome-in-a-porcine-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#12
Michael Weykamp, Vahagn C Nikolian, Isabel S Dennahy, Gerald A Higgins, Patrick E Georgoff, Henriette Remmer, Mohamed H Ghandour, Hasan B Alam
BACKGROUND: Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma. Although VPA is known to modulate transcription, its ability to reduce mortality within minutes of administration suggests involvement of a rapid, posttranslational mechanism. We hypothesized that VPA treatment would cause proteomic changes within minutes of treatment including quantitative and/or posttranslational differences in structural and/or effector proteins...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907217/hydrogen-rich-water-attenuates-oxidative-stress-in-rats-with-traumatic-brain-injury-via-nrf2-pathway
#13
Jia Yuan, Difen Wang, Ying Liu, Xianjun Chen, Hailing Zhang, Feng Shen, Xu Liu, Jiangquan Fu
BACKGROUND: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly understood. The purpose of our study was to evaluate the neuroprotective role of hydrogen-rich water in rats with TBI and to elucidate the possible mechanisms underlying its effects...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29905916/epidemiological-trends-of-traumatic-brain-and-spinal-cord-injury-in-puerto-rico-from-november-10th-2006-through-may-24th-2011
#14
Ricardo H Brau, Yaritza Acevedo-Salas, Katya Giovannetti
OBJECTIVE: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today. METHODS: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Quantitative variables were expressed as means and averages (plus/minus standard deviation); bivariate cross-tabulation and multiple regression analyses were employed to identify risk factors and compare epidemiological patterns of injury related variables...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905883/hypertonic-saline-or-mannitol-for-treating-elevated-intracranial-pressure-in-traumatic-brain-injury-a-meta-analysis-of-randomized-controlled-trials
#15
Jiajie Gu, Haoping Huang, Yuejun Huang, Haitao Sun, Hongwu Xu
Hyperosmolar therapy is regarded as the mainstay for treatment of elevated intracranial pressure (ICP) in traumatic brain injury (TBI). This still has been disputed as application of hypertonic saline (HS) or mannitol for treating patients with severe TBI. Thus, this meta-analysis was performed to further compare the advantages and disadvantages of mannitol with HS for treating elevated ICP after TBI. We conducted a systematic search on PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wan Fang Data, VIP Data, SinoMed, and China National Knowledge Infrastructure (CNKI) databases...
June 15, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29905055/-effect-of-chitosan-porous-scaffolds-combined-with-bone-marrow-mesenchymal-stem-cells-in-repair-of-neurological-deficit-after-traumatic-brain-injury-in-rats
#16
Keke Tan, Xiuxiu Wang, Jun Zhang, Zhigang Zhuang, Tieli Dong
Objective: To investigate the possibility and effect of chitosan porous scaffolds combined with bone marrow mesenchymal stem cells (BMSCs) in repair of neurological deficit after traumatic brain injury (TBI) in rats. Methods: BMSCs were isolated, cultured, and passaged by the method of bone marrow adherent culture. The 3rd generation BMSCs were identified by the CD29 and CD45 surface antigens and marked by 5-bromo-2-deoxyuridine (BrdU). The chitosan porous scaffolds were produced by the method of freeze-drying...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904892/neuroimaging-abnormalities-in-neurological-patients-with-criminal-behavior
#17
REVIEW
R Ryan Darby
PURPOSE OF REVIEW: Criminal behavior occurs in previously law-abiding neurological patients, including patients with traumatic brain injury, focal brain lesions, and dementia. Neuroimaging abnormalities in these patients allow one to explore the potential neuroanatomical correlates of criminal behavior. However, this process has been challenging because (1) It is difficult to determine the temporal relationship between criminal behavior and neurological disease onset; (2) Abnormalities in several different brain regions have been associated with criminal behavior; and (3) It is difficult to quantify neuroimaging abnormalities in individual subjects...
June 14, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29902960/white-matter-correlates-of-different-aspects-of-facial-affect-recognition-impairment-following-traumatic-brain-injury
#18
Arianna Rigon, Michelle W Voss, Lyn S Turkstra, Bilge Mutlu, Melissa C Duff
Although facial affect recognition deficits are well documented in individuals with moderate-to-severe traumatic brain injury (TBI), little research has examined the neural mechanisms underlying these impairments. Here, we use diffusion tensor imaging (DTI), specifically the scalars fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD), to examine relationships between regional white-matter integrity and two facial affect sub-skills: perceptual affect recognition abilities (measured by an affect matching task) and verbal categorization of facial affect (measured by an affect labeling task)...
June 14, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29901425/novel-metabolomic-comparison-of-arterial-and-jugular-venous-blood-in-severe-adult-tbi-patients-and-the-impact-of-pentobarbital-infusion
#19
Stephanie M Wolahan, Elliott Lebby, Howard C Mao, David McArthur, Courtney Real, Paul M Vespa, Daniel Braas, Thomas C Glenn
Treatment of severe traumatic brain injury (TBI) in the intensive care unit focuses on controlling intracranial pressure, ensuring sufficient cerebral perfusion, and monitoring for secondary injuries. Yet there are limited prognostic tools and no biomarkers or tests of the evolving neuropathology. Metabolomics has the potential to be a powerful tool to indirectly monitor evolving dysfunctional metabolism. We compared metabolite levels in simultaneously collected arterial and jugular venous samples in acute TBI patients undergoing intensive care as well as in healthy control volunteers...
June 14, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29896457/ankylosing-neurogenic-myositis-ossificans-of-the-hip-a-case-series-and-review-of-literature
#20
Byung-Ho Yoon, In Keun Park, Yerl-Bo Sung
Purpose: Neurogenic myositis ossificans (NMO) in patients with traumatic spinal cord or brain injuries can cause severe joint ankylosis or compromise neurovascularture. The purpose of this study was to evaluate the clinical and radiological outcomes of and review considerations relevant to surgical resection of NMO of the hip joint. Materials and Methods: Six patients (9 hips) underwent periarticular NMO resection between 2015 and 2017. The medical records of these patients were retrospectively reviewed...
June 2018: Hip & Pelvis
keyword
keyword
568
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"