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Severe traumatic brain injury

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https://www.readbyqxmd.com/read/28529492/depression-in-men-and-women-one-year-following-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#1
Sarah Lavoie, Samantha Sechrist, Nhung Quach, Reza Ehsanian, Thao Duong, Ian H Gotlib, Linda Isaac
In the general population, females experience depression at significantly higher rates than males. Individuals with traumatic brain injury (TBI) are at substantially greater risk for depression compared to the overall population. Treatment of, and recovery from, TBI can be hindered by depression; comorbid TBI and depression can lead to adverse outcomes and negatively affect multiple aspects of individuals' lives. Gender differences in depression following TBI are not well understood, and relevant empirical findings have been mixed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28528969/limitation-of-life-sustaining-treatment-in-severe-trauma-in-the-elderly-after-admission-to-an-intensive-care-unit
#2
Y Peñasco, A González-Castro, J C Rodríguez Borregán, M Ortiz-Lasa, R Jáuregui Solórzano, M J Sánchez Arguiano, P Escudero Acha
OBJECTIVE: To analyze the factors associated to limitation of life-sustaining treatment (LLST) measures in elderly patients admitted to an intensive care unit (ICU) due to trauma. DESIGN: A retrospective, descriptive, observational study was carried out. SETTING: ICU. PATIENTS: A total of 149 patients aged 65 years or older admitted to the ICU due to trauma. Hospital mortality, the decision to limit life-sustaining treatment and the factors associated to these measures were analyzed...
May 18, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28527714/investigation-of-left-and-right-lateral-fluid-percussion-injury-in-c57bl6-j-mice-in-vivo-functional-consequences
#3
Lesley D Schurman, Terry L Smith, Anthony J Morales, Nancy N Lee, Thomas M Reeves, Linda L Phillips, Aron H Lichtman
Although rodent models of traumatic brain injury (TBI) reliably produce cognitive and motor disturbances, behavioral characterization resulting from left and right hemisphere injuries remains unexplored. Here we examined the functional consequences of targeting the left versus right parietal cortex in lateral fluid percussion injury, on Morris water maze (MWM) spatial memory tasks (fixed platform and reversal) and neurological motor deficits (neurological severity score and rotarod). In the MWM fixed platform task, right lateral injury produced a small delay in acquisition rate compared to left...
May 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28524120/proton-magnetic-resonance-spectroscopy-%C3%A2-h-mrs-study-of-early-traumatic-brain-injury-in-rabbits
#4
Yong Xiao, Yigang Fu, Yi Zhou, Jianguo Xia, Lina Wang, Chunhong Hu
BACKGROUND The aim of this study was to investigate the relationship between dynamic changes of cerebral metabolism and degree of trauma in rabbit models of traumatic brain injury (TBI) by using proton magnetic resonance spectroscopy (¹H-MRS). MATERIAL AND METHODS Thirty-five Chinese rabbits were randomly divided into control, mild, moderate, and severe TBI groups. ¹H-MRS was performed 1, 6, and 24 h after trauma. The concentrations of NAA, Cr, Cho, and Lac, and NAA/Cr and Cho/Cr ratios in each group, were estimated...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28524035/-comparison-of-risk-of-death-between-older-and-non-older-critical-patients-in-icu-a-retrospective-cohort-study-of-consecutive-3-years
#5
Yeting Zhou, Daoming Tong, Shaodan Wang, Liansong Liu, Song Ye, Benwen Xu
OBJECTIVE: To investigate the risk of death between older and non-older critical patients in intensive care unit (ICU) in Shuyang People's Hospital. METHODS: A retrospective cohort study was conducted. The critical patients who aged 15 or above, and admitted to ICU of Shuyang People's Hospital from January 2014 to December 2016 were enrolled, and all the data was collected from the registration and electronic medical records in the ICU. The prevalence and causes of death in ICU critical patients during the study period were observed...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28522414/therapeutic-potential-of-agmatine-for-cns-disorders
#6
REVIEW
Vivian B Neis, Priscila B Rosa, Gislaine Olescowicz, Ana Lúcia S Rodrigues
Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling pathways. Several studies have focused on elucidating the mechanisms underlying the neuroprotective effects of this molecule, which seems to be mediated by a reduction in oxidative damage, neuroinflammation, and proapoptotic signaling. Since these events are implicated in acute and chronic excitotoxicity-related disorders (ischemia, epilepsy, traumatic brain injury, spinal cord injury, neurodegenerative, and psychiatric disorders) as well as in nociception, agmatine has been proposed as a therapeutic strategy for the treatment of central nervous system (CNS) disorders...
May 15, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28522089/sleep-stage-distribution-in-persons-with-mild-traumatic-brain-injury-a-polysomnographic-study-according-to-american-academy-of-sleep-medicine-standards
#7
Tatyana Mollayeva, Angela Colantonio, J David Cassidy, Lee Vernich, Rahim Moineddin, Colin M Shapiro
OBJECTIVE AND BACKGROUND: Sleep stage disruption in persons with mild traumatic brain injury (mTBI) has received little research attention. We examined deviations in sleep stage distribution in persons with mTBI relative to population age- and sex-specific normative data and the relationships between such deviations and brain injury-related, medical/psychiatric, and extrinsic factors. PATIENTS AND METHODS: We conducted a cross-sectional polysomnographic investigation in 40 participants diagnosed with mTBI (mean age 47...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521527/employment-outcome-four-years-after-a-severe-traumatic-brain-injury-results-of-the-paris-severe-traumatic-brain-injury-study
#8
Alexis Ruet, Claire Jourdan, Eléonore Bayen, Emmanuelle Darnoux, Dalila Sahridj, Idir Ghout, Sylvie Azerad, Pascale Pradat Diehl, Philippe Aegerter, James Charanton, Claire Vallat Azouvi, Philippe Azouvi
OBJECTIVE: To describe employment outcome four years after a severe traumatic brain injury by the assessment of individual patients' preinjury sociodemographic data, injury-related and postinjury factors. DESIGN: A prospective, multicenter inception cohort of 133 adult patients in the Paris area (France) who had received a severe traumatic brain injury were followed up postinjury at one and four years. Sociodemographic data, factors related to injury severity and one-year functional and cognitive outcomes were prospectively collected...
May 18, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28520686/clinical-correlates-to-assist-with-chronic-traumatic-encephalopathy-diagnosis-insights-from-a-novel-rodent-repeat-concussion-model
#9
Gretchen M Thomsen, Ara Ko, Megan Y Harada, Annie Ma, Livia Wyss, Patricia Haro, Jean-Philippe Vit, Pablo Avalos, Navpreet K Dhillon, Noell Cho, Oksana Shelest, Eric J Ley
INTRODUCTION: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. Chronic traumatic encephalopathy symptoms include changes in mood, behavior, cognition, and motor function; however, CTE is currently diagnosed only postmortem. Using a rat model of recurrent traumatic brain injury (TBI), we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. METHODS: Bilateral, closed-skull, mild TBI was administered once per week to 35 wild-type rats; eight rats received two injuries (2×TBI), 27 rats received five injuries (5×TBI), and 13 rats were sham controls...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28520675/the-role-of-cognitive-reserve-in-recovery-from-traumatic-brain-injury
#10
Kayla A Steward, Richard Kennedy, Thomas A Novack, Michael Crowe, Daniel C Marson, Kristen L Triebel
OBJECTIVE: To examine whether cognitive reserve (CR) attenuates the initial impact of traumatic brain injury (TBI) on cognitive performance (neural reserve) and results in faster cognitive recovery rates in the first year postinjury (neural compensation), and whether the advantage of CR differs on the basis of the severity of TBI. SETTING: Inpatient/outpatient clinics at an academic medical center. PARTICIPANTS: Adults with mild TBI (mTBI; n = 28), complicated mild TBI (cmTBI; n = 24), and moderate to severe TBI (msevTBI; n = 57), and demographically matched controls (n = 66)...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520673/behavioral-clinical-trials-in-moderate-to-severe-pediatric-traumatic-brain-injury-challenges-potential-solutions-and-lessons-learned
#11
Shari L Wade, Brad G Kurowski
The purpose of this commentary is to outline the challenges encountered when conducting clinical trials of interventions for pediatric traumatic brain injury (TBI) and share potential solutions for surmounting these issues. This commentary grows out of our experience implementing 8 randomized clinical trials (RCTs) of family-centered interventions to reduce child behavior problems and caregiver/parent distress following pediatric brain injury. These studies, involving more than 600 participants from 8 clinical centers, support the feasibility of conducting RCTs with children who have sustained TBIs while highlighting potential challenges and threats to validity...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520672/sertraline-for-major-depression-during-the-year-following-traumatic-brain-injury-a-randomized-controlled-trial
#12
Jesse R Fann, Charles H Bombardier, Nancy Temkin, Peter Esselman, Catherine Warms, Jason Barber, Sureyya Dikmen
OBJECTIVE: Major depressive disorder (MDD) is common and associated with impaired functioning after traumatic brain injury (TBI). Few placebo-controlled antidepressant trials exist in this population. We evaluated the efficacy and tolerability of sertraline for MDD within 1 year of sustaining a TBI. SETTING: Level I trauma center. PARTICIPANTS: Adults with MDD within 1 year of hospitalization for complicated mild to severe TBI. DESIGN: Randomized, double-blind, placebo-controlled trial...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520671/living-life-after-traumatic-brain-injury-phase-1-of-a-longitudinal-qualitative-study
#13
Kathryn McPherson, Joanna Fadyl, Alice Theadom, Alexis Channon, William Levack, Nicola Starkey, Laura Wilkinson-Meyers, Nicola Kayes
OBJECTIVE: To explore what helps and hinders recovery and adaptation after disabling traumatic brain injury (TBI) and make recommendations for improving service responsiveness. DESIGN: A longitudinal qualitative descriptive study across all TBI severities. SETTING: Community. PARTICIPANTS: Forty people with TBI, and 22 significant others, 6 to 9 months following a TBI. MAIN MEASURES: Semistructured interviews, analyzed using qualitative description, focused on (a) key areas of importance or concern and (b) strategies or actions that people found helpful or that hindered recovery...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520670/neutrophil-to-lymphocyte-ratio-as-a-novel-predictor-of-outcome-in-patients-with-severe-traumatic-brain-injury
#14
Weiqiang Chen, Jinhua Yang, Bingbing Li, Guoyi Peng, Tianfei Li, Lianjie Li, Shousen Wang
OBJECTIVE: The neutrophil to lymphocyte ratio (NLR) has been reported to be a predictor of outcome in critical illness. Objective of this study was to investigate the changes of the NLR in patients with severe traumatic brain injury (TBI) and analyze the relationship between the NLR and TBI outcome. SETTING: China. PARTICIPANTS: A total of 855 patients with severe TBI from January 2007 to April 2012. DESIGN: Retrospective...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520669/investigating-the-connection-between-traumatic-brain-injury-and-posttraumatic-stress-symptoms-in-adolescents
#15
Tara Rhine, Amy Cassedy, Keith Owen Yeates, Hudson Gerry Taylor, Michael W Kirkwood, Shari L Wade
OBJECTIVE: To identify potentially modifiable individual and social-environmental correlates of posttraumatic stress symptoms (PTSS) among adolescents hospitalized for traumatic brain injury (TBI). SETTING: Four pediatric hospitals and 1 general hospital in the United States. PARTICIPANTS: Children ages 11 to 18 years, hospitalized for moderate-severe TBI within the past 18 months. DESIGN: Retrospective cross-sectional analysis...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520667/supervision-needs-following-veteran-and-service-member-moderate-to-severe-traumatic-brain-injury-a-va-tbi-model-systems-study
#16
Erin K Bailey, Risa Nakase-Richardson, Nitin Patel, Christina Dillahunt-Aspillaga, Susan A Ropacki, Angelle M Sander, Lillian Stevens, Xinyu Tang
OBJECTIVE: To characterize supervision levels across residential settings at 1 year post-TBI and explore predictors of supervision in a Veteran and Service-member population. SETTING: Five VA Polytrauma Rehabilitation Centers. PARTICIPANTS: A total of 302 individuals enrolled in the VA TBI Model Systems (TBIMS) research program. DESIGN: Prospective, longitudinal, multisite. MAIN MEASURES: Primary residence and supervision levels measured via scores on the Supervision Rating Scale...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520666/anger-self-management-training-for-chronic-moderate-to-severe-traumatic-brain-injury-results-of-a-randomized-controlled-trial
#17
Tessa Hart, Jo Ann Brockway, Roland D Maiuro, Monica Vaccaro, Jesse R Fann, David Mellick, Cindy Harrison-Felix, Jason Barber, Nancy Temkin
OBJECTIVE: To test efficacy of 8-session, 1:1 treatment, anger self-management training (ASMT), for chronic moderate to severe traumatic brain injury (TBI). SETTING: Three US outpatient treatment facilities. PARTICIPANTS: Ninety people with TBI and elevated self-reported anger; 76 significant others (SOs) provided collateral data. DESIGN: Multicenter randomized controlled trial with 2:1 randomization to ASMT or structurally equivalent comparison treatment, personal readjustment and education (PRE)...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520664/follow-up-care-adherence-after-hospital-discharge-in-children-with-traumatic-brain-injury
#18
Alexandra J Spaw, Jennifer P Lundine, Sarah A Johnson, Jin Peng, Krista K Wheeler, Junxin Shi, Ginger Yang, Kathy J Haley, Jonathan I Groner, Henry Xiang
OBJECTIVE: To investigate factors associated with follow-up care adherence in children hospitalized because of traumatic brain injury (TBI). DESIGN: An urban level 1 children's hospital trauma registry was queried to identify patients (2-18 years) hospitalized with a TBI in 2013 to 2014. Chart reviewers assessed discharge summaries and follow-up instructions in 4 departments. MAIN MEASURES: Three levels of adherence-nonadherence, partial adherence, and full adherence-and their associations with care delivery, patient, and injury factors...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520662/anxiety-disorders-in-adults-with-childhood-traumatic-brain-injury-evidence-of-difficulties-more-than-10-years-postinjury
#19
Michelle Albicini, Audrey McKinlay
OBJECTIVE: To explore long-term psychiatric outcomes in individuals with a history of childhood traumatic brain injury (TBI) or orthopedic injury (OI). SETTING: Hospital emergency department, medical admission records and outpatient settings. PARTICIPANTS: There were 95 males (M = 22.78 years, SD = 3.44 years) and 74 females (M = 22.27 years, SD = 3.09 years), 65 with mild TBI (M = 23.25 years, SD = 3.58 years), 61 with moderate-severe TBI (M = 22...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520659/predictors-of-satisfaction-with-life-in-veterans-after-traumatic-brain-injury-a-va-tbi-model-systems-study
#20
Leah R Gause, Jacob A Finn, Greg J Lamberty, Xinyu Tang, Lillian Flores Stevens, Blessen C Eapen, Risa Nakase-Richardson
OBJECTIVE: To identify predictors of satisfaction with life in Veterans 1 year after traumatic brain injury (TBI). SETTING: The VA TBI Model Systems (TBIMS) project includes 5 Veterans Affairs (VA) Polytrauma Rehabilitation Centers. PARTICIPANTS: Veterans enrolled in the VA TBIMS study who completed the Satisfaction With Life Scale at year 1 follow-up. The sample is largely male (96%) and Caucasian (72%), with a median age of 27 years upon enrollment...
May 17, 2017: Journal of Head Trauma Rehabilitation
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