Soohyun Um, Jaeyoun Lee, Sung Jin Kim, Kyung A Cho, Ki Sung Kang, Seung Hyun Kim
Xinghamide A ( 1 ), a new nonapeptide, was discovered in Streptomyces xinghaiensis isolated from a halophyte, Suaeda maritima (L.) Dumort. Based on high-resolution mass and NMR spectroscopic data, the planar structure of 1 was established, and, in particular, the sequence of nine amino acids was determined with ROESY and HMBC NMR spectra. The absolute configurations of the α-carbon of each amino acid residue were determined with 1-fluoro-2,4-dinitrophenyl-l-and -d-leucine amide (Marfey's reagents) and 2,3,4,6-tetra- O -acetyl-β-d-glucopyranosyl isothiocyanate, followed by LC-MS analysis...
September 26, 2023: Marine Drugs