keyword
https://read.qxmd.com/read/37901519/minor-nonterpenoid-volatile-compounds-drive-the-aroma-differences-of-exotic-cannabis
#21
JOURNAL ARTICLE
Iain W H Oswald, Twinkle R Paryani, Manuel E Sosa, Marcos A Ojeda, Mark R Altenbernd, Jonathan J Grandy, Nathan S Shafer, Kim Ngo, Jack R Peat, Bradley G Melshenker, Ian Skelly, Kevin A Koby, Michael F Z Page, Thomas J Martin
Cannabis sativa L. produces a wide variety of volatile secondary metabolites that contribute to its unique aroma. The major volatile constituents include monoterpenes, sesquiterpenes, and their oxygenated derivates. In particular, the compounds ß-myrcene, D-(+)-limonene, ß-caryophyllene, and terpinolene are often found in greatest amounts, which has led to their use in chemotaxonomic classification schemes and legal Cannabis sativa L. product labeling. While these compounds contribute to the characteristic aroma of Cannabis sativa L...
October 24, 2023: ACS Omega
https://read.qxmd.com/read/37885259/screening-of-potent-inhibitor-from-aquilaria-malaccensis-lam-against-arachidonic-inflammatory-enzymes-an-insight-from-molecular-docking-admet-molecular-dynamics-simulation-and-mm-pbsa-approaches
#22
JOURNAL ARTICLE
Prasanna Sarmah, Parthapratim Konwar, Jadumoni Saikia, Twinkle Borah, Jitendra Singh Verma, Dipanwita Banik
The three primary enzymes COX (cyclooxygenase), LOX (lipoxygenase) and CYT-P450 (cytochrome P450), which are part of the arachidonic inflammatory pathway, play crucial role in the development of asthma, rheumatoid arthritis and cardiovascular diseases. Ethnomedicinally, plant-derived chemicals have a major role in the treatment of fatal illnesses. Aquilaria malaccensis Lam. widely known as agarwood is prized for its fragrance and therapeutic properties. The phytochemicals and extracts of this plant have significant healing properties in the treatment of serious illnesses...
October 26, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37870009/usefulness-of-children-s-hospital-of-philadelphia-rop-chop-rop-model-in-the-prediction-of-type-1-rop
#23
JOURNAL ARTICLE
Barkha Jain, Neha K Sethi, Amanpreet Sethi, Rhythm Arora, Twinkle Gupta, Harnoor Kaur
PURPOSE: Children's Hospital of Philadelphia retinopathy of prematurity (CHOP ROP) model can be used to predict ROP, a leading cause of childhood blindness, using risk factors such as postnatal weight gain, birth weight (BW), and gestation age (GA). The purpose of this study was to determine the usefulness of the CHOP ROP for the prediction of treatable ROP. METHODS: This was a prospective observational study. Babies <34 weeks of GA, BW <2000 grams, and GA 34-36 weeks with risk factors such as respiratory distress syndrome (RDS) were included; ROP screening, follow-up, and treatment were performed based on national guidelines...
November 2023: Indian Journal of Ophthalmology
https://read.qxmd.com/read/37845929/218-11-directed-deceased-donation-experience-from-india
#24
JOURNAL ARTICLE
Avnish Seth, Sukhvinder Lal, Sumana Navin, Twinkle Singh, Sunil Shroff, Anant Kumar
No abstract text is available yet for this article.
October 1, 2023: Transplantation
https://read.qxmd.com/read/37842872/outcomes-of-kidney-liver-and-simultaneous-liver-and-kidney-transplants-from-hepatitis-c-infected-donors-to-hepatitis-c-na%C3%A3-ve-recipients-a-large-single-center-experience
#25
JOURNAL ARTICLE
Hany Elbeshbeshy, Neal Modi, Twinkle Patel, Ian Matthews, Timothy Kampert, Jaenic Lee, Raymond Okeke, Yasar Caliskan, Vidyaratna Fleetwood, Chintalapati Varma, Brittney Gabris, Bahar Bastani, Fadee Abu Al Rub, Alexis Guenette, Alex Befeler, Uchenna Agbim, Roshani Desai, Eyad Alsabbagh, Kamran Qureshi, Mark Schnitzler, Krista L Lentine, Henry B Randall, Mustafa Nazzal
BACKGROUND: With the introduction of direct-acting antiviral therapies (DAAs), the non-use rate of hepatitis C virus (HCV)-positive donor organs (D+) has decreased significantly. We present the donor, recipient, and transplant allograft characteristics, along with recipient outcomes, in one of the largest cohorts of HCV-D+ transplants into HCV-naïve recipients (R-). METHODS: Charts of HCV D+/R- kidney (KT), liver (LT), and simultaneous liver-kidney (SLKT) transplant recipients between January 2019 and July 2022 were reviewed...
October 16, 2023: Clinical Transplantation
https://read.qxmd.com/read/37803262/the-plant-organellar-primase-helicase-directs-template-recognition-and-primosome-assembly-via-its-zinc-finger-domain
#26
JOURNAL ARTICLE
Antolin Peralta-Castro, Francisco Cordoba-Andrade, Corina Díaz-Quezada, Rogerio Sotelo-Mundo, Robert Winkler, Luis G Brieba
BACKGROUND: The mechanisms and regulation for DNA replication in plant organelles are largely unknown, as few proteins involved in replisome assembly have been biochemically studied. A primase-helicase dubbed Twinkle (T7 gp4-like protein with intramitochondrial nucleoid localization) unwinds double-stranded DNA in metazoan mitochondria and plant organelles. Twinkle in plants is a bifunctional enzyme with an active primase module. This contrast with animal Twinkle in which the primase module is inactive...
October 6, 2023: BMC Plant Biology
https://read.qxmd.com/read/37797455/a-novel-class-of-pyrazole-analogues-as-aurora-kinase-a-inhibitor-design-synthesis-and-anticancer-evaluation
#27
JOURNAL ARTICLE
Digambar B Yevale, Nishith Teraiya, Twinkle D Lalwani, Rakesh Kumar Ameta, Chetan B Sangani
Pyrazole, as a small molecule, was discovered for higher cytotoxicity and affinity towards Aurora-A kinase. Based on these facts, a novel pyrazole substituted at the 4th position was designed, synthesized, and evaluated against MCF-7, MDA-MB-23, and Vero (non-cancerous kidney cell) cell lines. Compounds5hand5eexhibited greater cytotoxicity in the series against MCF-7 and MDA-MB-231, with GI50 values of 0.12 µM and 0.63 µM, respectively, as compared to Imatinib (GI50 values of 16.08 µM and 10...
October 1, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/37779423/wound-management-provided-by-advanced-practice-nurses-a-scoping-review
#28
JOURNAL ARTICLE
Sherry Morrell, Gina Pittman, Rachel Elliott, Erin Ziegler, Sylwia Borawski, Adam Mulcaster, Andrew Hebert, Twinkle Patel, Aya Dannawey
OBJECTIVE: The objective of the review was to map the similarities and differences in the wound care practices of nurse practitioners, clinical nurse specialists, and advanced practice registered nurses, globally. INTRODUCTION: Advanced practice nurses have graduate education and advanced scope of practice. Adding advanced wound care training to their skillset provides an opportunity for advanced practice nurses to provide wound care. INCLUSION CRITERIA: This review considered for inclusion advanced practice nurses globally who are registered nurses with graduate-level education and advanced training (certification/education) in wound care in any setting...
September 28, 2023: JBI evidence synthesis
https://read.qxmd.com/read/37772245/comparative-dynamic-pulmonary-function-tests-between-apparently-healthy-young-adult-offspring-of-asthmatic-and-non-asthmatic-parents-a-pilot-study
#29
JOURNAL ARTICLE
Reddipogu Havilah Twinkle, Yukta Sain, Mohammed Jaffer Pinjar, Khaleel Ahmed Manik, Himel Mondal
Background While the hereditary component of asthma has been established, its influence on early respiratory function changes in otherwise healthy offspring remains to be explored. Dynamic lung function tests assess airflow in and out of the lungs, providing valuable insights into respiratory health and detecting potential airflow limitations. This study aimed to compare the dynamic lung functions between offspring of asthmatic and non-asthmatic parents. Methodology A case-control design was employed comprising 30 cases (offspring of asthmatic parents) and 30 controls (offspring of non-asthmatic parents)...
August 2023: Curēus
https://read.qxmd.com/read/37703000/exploring-the-extent-to-which-shared-mechanisms-contribute-to-motion-position-illusions
#30
JOURNAL ARTICLE
Timothy V Cottier, William Turner, Alex O Holcombe, Hinze Hogendoorn
Motion-position illusions (MPIs) are visual motion illusions in which motion signals bias the perceived position of an object. Due to phenomenological similarities between these illusions, previous research has assumed that some are caused by common mechanisms. However, this assumption has yet to be directly tested. This study investigates this assumption by exploiting between-participant variations in illusion magnitude. During two sessions, 106 participants viewed the flash-lag effect, luminance flash-lag effect, Fröhlich effect, flash-drag effect, flash-grab effect, motion-induced position shift, twinkle-goes effect, and the flash-jump effect...
September 1, 2023: Journal of Vision
https://read.qxmd.com/read/37687076/a-comprehensive-review-on-bioactive-compounds-found-in-caesalpinia-sappan
#31
REVIEW
Twinkle Vij, Pawase Prashant Anil, Rafeeya Shams, Kshirod Kumar Dash, Rhythm Kalsi, Vinay Kumar Pandey, Endre Harsányi, Béla Kovács, Ayaz Mukarram Shaikh
Sappan wood ( Caesalpinia sappan ) is a tropical hardwood tree found in Southeast Asia. Sappan wood contains a water-soluble compound, which imparts a red color named brazilin. Sappan wood is utilized to produce dye for fabric and coloring agents for food and beverages, such as wine and meat. As a valuable medicinal plant, the tree is also known for its antioxidant, anti-inflammatory, and anticancer properties. It has been observed that sappan wood contains various bioactive compounds, including brazilin, brazilein, sappan chalcone, and protosappanin A...
August 25, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37678607/long-term-cryopreservation-of-peripheral-blood-stem-cell-harvest-using-low-concentration-4-35-dimethyl-sulfoxide-with-methyl-cellulose-and-uncontrolled-rate-freezing-at-80%C3%A2-c-an-effective-option-in-resource-limited-setting
#32
JOURNAL ARTICLE
Anant Gokarn, Prashant R Tembhare, Hasan Syed, Isha Sanyal, Rohit Kumar, Sarika Parab, Twinkle Khanka, Sachin Punatar, Shweta Kedia, Sitaram G Ghogale, Nilesh Deshpande, Yuvraj Nikam, Karishma Girase, Sumeet Mirgh, Nishant Jindal, Bhausaheb Bagal, Akanksha Chichra, Lingaraj Nayak, Avinash Bonda, Sushmita Rath, Sumathi Hiregoudar, Minal Poojary, Suryatapa Saha, Shashank Ojha, Papagudi G Subramanian, Navin Khattry
BACKGROUND: Long-term cryopreservation of peripheral blood stem cells (PBSCs) is highly useful in the setting of tandem/multiple transplants, or treatment of relapse in autologous transplant setting. Even in allogeneic transplants donor lymphocyte infusions may be stored for months to years if excess stem cells are collected from donors. Cryopreservation is a delicate, complex, and costly procedure and higher concentrations dimethyl sulfoxide (DMSO), which is a commonly used cryo-protectant, can be toxic to cells and cause adverse effects to the recipient during infusions...
September 5, 2023: Transplantation and cellular therapy
https://read.qxmd.com/read/37664262/classification-of-chemotherapy-induced-febrile-neutropenic-episodes-into-one-of-the-three-febrile-neutropenic-syndromes
#33
JOURNAL ARTICLE
Ronak Raheja, Neelesh Reddy, Twinkle Patel, Srikar Kilambi, Ashik A Mathew, Abdul Majeed
Introduction Febrile neutropenia is a commonly encountered medical emergency in patients undergoing cancer treatment and can delay and modify the course of treatment and even lead to dire outcomes, including death. The cause of fever in a post-chemotherapy-induced neutropenic patient can be confusing to treating physicians. A review of the literature demonstrated that blood culture results could determine the cause of febrile neutropenia in only approximately 10% to 25% of patients. The objective of our study was to measure the incidence of positive blood cultures, urine cultures, and other body fluid cultures resulting in chemotherapy-induced neutropenia and further classify fever episodes into three neutropenic fever syndromes, such as microbiologically documented, clinically suspected, or unknown causes of fever, respectively...
August 2023: Curēus
https://read.qxmd.com/read/37658140/prospective-evaluation-of-ultrasound-features-of-magnesium-based-bioabsorbable-screw-resorption-in-pediatric-fractures
#34
JOURNAL ARTICLE
Stephan L Waelti, Jozef Fandak, Stefan Markart, Erik P Willems, Simon Wildermuth, Tim Fischer, Tobias J Dietrich, Christoph Matissek, Thomas Krebs
OBJECTIVE: Bioabsorbable magnesium-based alloy screws release gas upon resorption. The resulting findings in the adjacent soft tissues and joints may mimic infection. The aim of the study was to evaluate the ultrasound (US) findings in soft tissues and joints during screw resorption. METHODS: Prospectively acquired US studies from pediatric patients treated with magnesium screws were evaluated for screw head visibility, posterior acoustic shadowing, twinkling artifact, foreign body granuloma, gas (soft tissue, intra-articular), alterations of the skin and subcutaneous fat, perifascial fluid, localized fluid collections, hypervascularization, and joint effusion...
September 2, 2023: European Radiology
https://read.qxmd.com/read/37652777/a-new-way-to-visualize-prostate-brachytherapy-needles-using-ultrasound-color-doppler-and-needle-surface-modifications
#35
JOURNAL ARTICLE
Justine M Dupere, Eric E Brost, Susheil Uthamaraj, Christine U Lee, Matthew W Urban, Bradley J Stish, Christopher L Deufel
PURPOSE: Suboptimal ultrasound conspicuity of the brachytherapy applicator can lead to inaccurate image reconstructions of the applicator resulting in decreased tumor control or increased normal tissue dose. This feasibility study aims to improve ultrasound conspicuity of high-dose rate (HDR) brachytherapy needles by modifying the surface of the needles to produce a color Doppler twinkling signature. MATERIALS AND METHODS: Surface modifications of standard 17-gauge titanium HDR brachytherapy needles included laser-scribing, application of polymethyl methacrylate (PMMA), and coating with a commercially available echogenic coating...
2023: Brachytherapy
https://read.qxmd.com/read/37636188/knowledge-attitude-and-practice-of-patients-visiting-a-private-primary-level-health-care-facility-towards-family-physicians
#36
JOURNAL ARTICLE
Hemavathi Dasappa, Twinkle Agrawal, Manuel Joy, Gherad Dhanpal Ravindran
AIM AND OBJECTIVE: To study the knowledge, perception, attitude, and practice of patients visiting a private primary health centre towards family physicians. METHODOLOGY: A cross-sectional questionnaire-based study was planned. RESULTS: A total of 272 patients visiting the health centre were included in the study. KNOWLEDGE: Above 90% of the patients felt confident in the capabilities of family physicians in managing all kinds of health problems and the time/cost-effectiveness of this speciality...
June 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/37611339/observed-evidence-for-the-impact-of-coastal-currents-on-the-recurrent-noctiluca-scintillans-blooms-in-the-northwest-indian-ocean-coast
#37
JOURNAL ARTICLE
Twinkle Sathish, Jayanarayanan Kuttippurath, Aishwarya Purushothaman, K S Amal, Renju Mohan, Lix John, Lathika Cicily Thomas, K B Padmakumar
Recently, South Eastern Arabian Sea (SEAS) experiences recurrent winter blooms of green Noctiluca scintillans with serious ecological consequences. Here, the analysis of green N. scintillans blooms in SEAS for the past three consecutive years (2018-2021) is presented. The daily monitoring showed intense winter blooms during November with stable sea surface temperatures, high nitrate-phosphate concentrations and relatively lower pH levels. Dissolved oxygen concentration decreased to near hypoxia in the later stages of the bloom...
August 21, 2023: Marine Pollution Bulletin
https://read.qxmd.com/read/37583536/a-cross-sectional-survey-to-assess-knowledge-attitude-and-practice-of-yoga-among-cancer-patients-at-a-tertiary-care-hospital
#38
JOURNAL ARTICLE
Amit Sehrawat, Sweta Malik, Shikha Mudgal, Twinkle Dogra, Sweety Gupta, Suresh Lal Barnwal, Jaya Chaturvedi, Deepak Sundriyal
BACKGROUND: Cancer incidence and mortality are rapidly growing worldwide. Cancer affects the overall quality of life of cancer patients. Yoga has its origin in the ancient times. This ancient practice has been used for holistic well-being for ages. Yoga as an alternative therapy might be beneficial for cancer patients too. This study was conducted to assess knowledge, attitudes, and yoga practices among cancer patients. MATERIALS AND METHODS: For this cross-sectional survey, a self-designed questionnaire was validated and distributed among 25 cancer patients for a pilot study...
2023: International Journal of Yoga
https://read.qxmd.com/read/37572224/application-of-ultrasound-imaging-in-the-treatment-of-urinary-tract-stones
#39
REVIEW
Shuzo Hamamoto, Takaaki Inoue, Shinsuke Okada, Kazumi Taguchi, Takahiro Yasui
Urinary tract stones are a common clinical condition that affect millions of individuals worldwide. The management of these stones has evolved significantly over the past 70 years, and ultrasound imaging has emerged as a valuable tool for diagnosis, treatment planning, and follow-up. This review aims to provide an overview of the application of ultrasound imaging in the treatment of urinary tract stones, highlighting its advantages, limitations, and current advancements in the field.
August 12, 2023: Journal of Medical Ultrasonics
https://read.qxmd.com/read/37505109/twinkling-a-useful-adjunct-for-identifying-biopsy-clips-on-us-images
#40
COMMENT
Gary J Whitman
No abstract text is available yet for this article.
July 2023: Radiology. Imaging cancer
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