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https://www.readbyqxmd.com/read/28281476/objective-ergonomic-risk-assessment-of-wrist-and-spine-with-motion-analysis-technique-during-simulated-laparoscopic-cholecystectomy-in-experienced-and-novice-surgeons
#1
Twinkle Yogesh Dabholkar, Sujata Sudhir Yardi, Sanjay Narahari Oak, Sneha Ramchandani
INTRODUCTION: There is a rise in prevalence of work-related musculoskeletal disorders in surgeons performing laparoscopic surgeries due to lack of ergonomic considerations to the minimal access surgical environment. The objective of this study was to assess the physical ergonomics in experienced and novice surgeons during a simulated laparoscopic cholecystectomy. METHODOLOGY: Thirty-two surgeons participated in this study and were distributed in two groups (experienced and novices) based on the inclusion criteria...
April 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28190622/effect-of-carbon-dioxide-on-the-twinkling-artifact-in-ultrasound-imaging-of-kidney-stones-a-pilot-study
#2
Julianna C Simon, Yak-Nam Wang, Bryan W Cunitz, Jeffrey Thiel, Frank Starr, Ziyue Liu, Michael R Bailey
Bone demineralization, dehydration and stasis put astronauts at increased risk of forming kidney stones in space. The color-Doppler ultrasound "twinkling artifact," which highlights kidney stones with color, can make stones readily detectable with ultrasound; however, our previous results suggest twinkling is caused by microbubbles on the stone surface which could be affected by the elevated levels of carbon dioxide found on space vehicles. Four pigs were implanted with kidney stones and imaged with ultrasound while the anesthetic carrier gas oscillated between oxygen and air containing 0...
February 9, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28178980/novel-neuro-audiological-findings-and-further-evidence-for-twnk-involvement-in-perrault-syndrome
#3
Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski, Henryk Skarżyński
BACKGROUND: Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations in one of five different genes HSD17B4, HARS2, LARS2, CLPP or TWNK (previous symbol C10orf2) cause the autosomal recessive disorder but they are found only in about half of the patients. METHODS: We report on two siblings with a clinical picture resembling a severe, neurological type of PRLTS...
February 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28167365/nitrogen-doped-graphene-quantum-dots-based-long-persistent-chemiluminescence-system-for-ascorbic-acid-imaging
#4
Hongjun Chen, Qin Wang, Qinpeng Shen, Xin Liu, Wang Li, Zhou Nie, Shouzhuo Yao
High photo-intensity and sluggish flight attenuation are important to highly sensitive chemluminescence imaging. Herein, we present a copper ion catalyzed long-persistent chemiluminescent imaging system of nitrogen-doped graphene quantum dots (NGQDs) for ascorbic acid detection in fruit. NGQDs as luminescent probe are fabricated, emitting out chemluminescence with the direct oxidation by H2O2. In addition, Cu(2+) ion enlarges over two order magnitudes of NGQDs CL intensity (214 times) due to its catalyzed Fenton-like reaction for H2O2 decomposition, and displaying unique specificity against other metal ions...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28042097/parkin-deficiency-accelerates-consequences-of-mitochondrial-dna-deletions-and-parkinsonism
#5
Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopassi
Parkinson's disease (PD) is a neurodegenerative condition caused by age-related death of dopaminergic (DA) neurons in the substantia nigra (SN). Mitochondrial DNA (mtDNA) deletions rise exponentially with age in humans and reach their highest levels approaching 60% in dopaminergic neurons of the substantia nigra and overlap with dying neurons. Parkin deletion causes Parkinsonism in humans, presumably through a decrease in mitochondrial quality control, but Parkin knockout mice do not have DA neurodegeneration...
December 29, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/28039937/quantitative-evaluation-of-the-effects-of-urinary-stone-composition-and-size-on-color-doppler-twinkling-artifact-a-phantom-study
#6
Mengmeng Shang, Xiao Sun, Qing Liu, Jie Li, Dandan Shi, Song Ning, Lin Cheng
OBJECTIVES: The present study was conducted to quantitatively evaluate the influence of urinary stone composition and size on color Doppler twinkling artifact. METHODS: Calcium oxalate monohydrate (COM), apatite, L-cystine, and uric acid (UA) stone phantoms with 10 different sizes were prepared artificially and embedded in the renal sinus of porcine kidneys in vitro. Color Doppler ultrasound scanning was performed on the phantoms and TA pictures were recorded. The length of the twinkling artifact (TAL) and width of twinkling artifact (TAW) were measured...
December 31, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28030582/therapeutic-targeting-of-the-mitochondria-initiates-excessive-superoxide-production-and-mitochondrial-depolarization-causing-decreased-mtdna-integrity
#7
Kaytee L Pokrzywinski, Thomas G Biel, Dmitry Kryndushkin, V Ashutosh Rao
Mitochondrial dysregulation is closely associated with excessive reactive oxygen species (ROS) production. Altered redox homeostasis has been implicated in the onset of several diseases including cancer. Mitochondrial DNA (mtDNA) and proteins are particularly sensitive to ROS as they are in close proximity to the respiratory chain (RC). Mitoquinone (MitoQ), a mitochondria-targeted redox agent, selectively damages breast cancer cells possibly through damage induced via enhanced ROS production. However, the effects of MitoQ and other triphenylphosphonium (TPP+) conjugated agents on cancer mitochondrial homeostasis remain unknown...
2016: PloS One
https://www.readbyqxmd.com/read/28029769/light-harvesting-and-amplified-energy-transfer-in-conjugated-polymer-nanoparticles
#8
Yifei Jiang, Jason McNeill
Conjugated polymer nanoparticles are a class of nanoparticles with many useful and interesting properties, including very high fluorescence brightness, excellent photostability, and sensing capabilities. They also exhibit interesting and potentially useful phenomena, such as highly efficient energy transfer, anomalous single particle blinking, and twinkling phenomena associated with polaron motion. As little as one dye molecule per nanoparticle can efficiently quench the fluorescence of hundreds of polymer chromophore units...
January 25, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28000651/objective-ergonomic-risk-assessment-of-wrist-and-spine-with-motion-analysis-technique-during-simulated-laparoscopic-cholecystectomy-in-experienced-and-novice-surgeons
#9
Twinkle Yogesh Dabholkar, Sujata Sudhir Yardi, Sanjay Narahari Oak, Sneha Ramchandani
INTRODUCTION: There is a rise in prevalence of work-related musculoskeletal disorders in surgeons performing laparoscopic surgeries due to lack of ergonomic considerations to the minimal access surgical environment. The objective of this study was to assess the physical ergonomics in experienced and novice surgeons during a simulated laparoscopic cholecystectomy. METHODOLOGY: Thirty-two surgeons participated in this study and were distributed in two groups (experienced and novices) based on the inclusion criteria...
December 21, 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27930563/combining-ultrasonography-and-noncontrast-helical-computerized-tomography-to-evaluate-holmium-laser-lithotripsy
#10
Jia Mi, Jie Li, Qinglu Zhang, Xing Wang, Hongyu Liu, Yanlu Cao, Xiaoyan Liu, Xiao Sun, Mengmeng Shang, Qing Liu
The purpose of the study was to establish a mathematical model for correlating the combination of ultrasonography and noncontrast helical computerized tomography (NCHCT) with the total energy of Holmium laser lithotripsy.In this study, from March 2013 to February 2014, 180 patients with single urinary calculus were examined using ultrasonography and NCHCT before Holmium laser lithotripsy. The calculus location and size, acoustic shadowing (AS) level, twinkling artifact intensity (TAI), and CT value were all documented...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27906631/mitochondrial-purine-and-pyrimidine-metabolism-and-beyond
#11
REVIEW
Liya Wang
Carefully balanced deoxynucleoside triphosphate (dNTP) pools are essential for both nuclear and mitochondrial genome replication and repair. Two synthetic pathways operate in cells to produce dNTPs, e.g., the de novo and the salvage pathways. The key regulatory enzymes for de novo synthesis are ribonucleotide reductase (RNR) and thymidylate synthase (TS), and this process is considered to be cytosolic. The salvage pathway operates both in the cytosol (TK1 and dCK) and the mitochondria (TK2 and dGK). Mitochondrial dNTP pools are separated from the cytosolic ones owing to the double membrane structure of the mitochondria, and are formed by the salvage enzymes TK2 and dGK together with NMPKs and NDPK in postmitotic tissues, while in proliferating cells the mitochondrial dNTPs are mainly imported from the cytosol produced by the cytosolic pathways...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27867407/twinkle-artefact-in-the-ultrasound-diagnosis-of-superficial-epidermoid-cysts
#12
Richard Clarke, Priya Suresh, Rose Thomas, Simon Freeman
AIM: The aim of the study was to evaluate whether the twinkle artefact is a valuable feature in the sonographic diagnosis of superficial epidermoid cysts. MATERIALS AND METHODS: A retrospective search was undertaken of our institution's Radiology Information System and pathology database to identify cases of superficial masses showing the twinkle artefact that proceeded to surgical excision. RESULTS: Eighteen superficial masses demonstrating the twinkle artefact were identified that were submitted for pathological analysis...
August 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27846700/droplet-like-heterogeneity-of-aqueous-tetrahydrofuran-solutions-at-the-submicrometer-scale
#13
N F Bunkin, A V Shkirin, G A Lyakhov, A V Kobelev, N V Penkov, S V Ugraitskaya, E E Fesenko
A droplet formation in aqueous solutions of tetrahydrofuran (THF) has been experimentally detected at the submicrometer scale using two independent laser diagnostic techniques (dynamic light scattering and laser phase microscopy) and described in terms of THF-water intermolecular hydrogen bonding. It is shown that the nanodroplets have a mean size of 300 nm, their refractive index is higher than that of the ambient liquid, and they are highly enriched with THF molecules. The maximum of light scattering intensity falls within the THF concentration range 2-8 mol...
November 14, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27814609/mitochondrial-nucleic-acid-binding-proteins-associated-with-diseases
#14
Takeshi Uchiumi, Dongchon Kang
Mammalian mitochondrial DNA (mtDNA) exists in structures called nucleoids, which correspond to the configuration of nuclear DNA. Mitochondrial transcription factor A (TFAM), first cloned as an mtDNA transcription factor, is critical for packaging and maintaining mtDNA. To investigate functional aspects of TFAM, we identified many RNA-binding proteins as candidate TFAM interactors, including ERAL1 and p32. In this review, we first describe the functions of TFAM, replication proteins such as polymerase gamma and Twinkle, and mitochondrial RNA binding proteins...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27687733/dominant-factor-analysis-of-b-flow-twinkling-sign-with-phantom-and-simulation-data
#15
Weijia Lu, Bruno Haider
BACKGROUND AND PURPOSE: The twinkling sign in B-flow imaging (BFI-TS) has been reported in the literature to increase both specificity and sensitivity compared to the traditional gray-scale imaging. Unfortunately, there has been no conclusive study on the mechanism of this effect. METHODS: In the study presented here, a comparative test on phantoms is introduced, where the variance of a phase estimator is used to quantify the motion amplitude. The statistical inference is employed later to find the dominate factor for the twinkling sign, which is proven by computer simulation...
January 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27551684/infantile-onset-spinocerebellar-ataxia-caused-by-compound-heterozygosity-for-twinkle-mutations-and-modeling-of-twinkle-mutations-causing-recessive-disease
#16
Sarah B Pierce, Suleyman Gulsuner, Gail A Stapleton, Tom Walsh, Ming K Lee, Jessica B Mandell, Augusto Morales, Rachel E Klevit, Mary-Claire King, R Curtis Rogers
Mutations in nuclear genes required for the replication and maintenance of mitochondrial DNA cause progressive multisystemic neuromuscular disorders with overlapping phenotypes. Biallelic mutations in C10orf2, encoding the Twinkle mitochondrial DNA helicase, lead to infantile-onset cerebellar ataxia (IOSCA), as well as milder and more severe phenotypes. We present a 13-year-old girl with ataxia, severe hearing loss, optic atrophy, peripheral neuropathy, and hypergonadotropic hypogonadism. Whole-exome sequencing revealed that the patient is compound heterozygous for previously unreported variants in the C10orf2 gene: a paternally inherited frameshift variant (c...
July 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27444386/mitochondria-targeted-antioxidant-mitotempo-protects-mitochondrial-function-against-amyloid-beta-toxicity-in-primary-cultured-mouse-neurons
#17
Hongtao Hu, Mo Li
Mitochondrial defects including excess reactive oxygen species (ROS) production and compromised ATP generation are featured pathology in Alzheimer's disease (AD). Amyloid beta (Aβ)-mediated mitochondrial ROS overproduction disrupts intra-neuronal Redox balance, in turn exacerbating mitochondrial dysfunction leading to neuronal injury. Previous studies have found the beneficial effects of mitochondria-targeted antioxidants in preventing mitochondrial dysfunction and neuronal injury in AD animal and cell models, suggesting that mitochondrial ROS scavengers hold promise for the treatment of this neurological disorder...
September 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27427710/imitating-musical-scores-on-a-chip-through-droplet-generation
#18
Xiaoyun Shawn Yang, Soojeong Shin, Woon Seob Lee, Jong Wook Hong
We have demonstrated fine control of droplet volumes on a chip using pneumatically actuated micro valve systems resulting in confined nanoliter or picoliter reagent generation. Using the micro valves, we are able to align multi-inlet droplet generating chips for systematic generation of combinatorial mixtures of chemical constituents. By following the change of chemical conditions such as pH we converted musical note information into sequential droplets representing musical scores of 'Twinkle little star.' It would just one of the interesting application of micro-droplet generation systems based on accurate droplet generation, mixing, and incubation...
June 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27364318/oxidative-dna-damage-stalls-the-human-mitochondrial-replisome
#19
Gorazd Stojkovič, Alena V Makarova, Paulina H Wanrooij, Josefin Forslund, Peter M Burgers, Sjoerd Wanrooij
Oxidative stress is capable of causing damage to various cellular constituents, including DNA. There is however limited knowledge on how oxidative stress influences mitochondrial DNA and its replication. Here, we have used purified mtDNA replication proteins, i.e. DNA polymerase γ holoenzyme, the mitochondrial single-stranded DNA binding protein mtSSB, the replicative helicase Twinkle and the proposed mitochondrial translesion synthesis polymerase PrimPol to study lesion bypass synthesis on oxidative damage-containing DNA templates...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27342873/twinkle-overexpression-prevents-cardiac-rupture-after-myocardial-infarction-by-alleviating-impaired-mitochondrial-biogenesis
#20
Takahiro Inoue, Masataka Ikeda, Tomomi Ide, Takeo Fujino, Yuka Matsuo, Shinobu Arai, Keita Saku, Kenji Sunagawa
Cardiac rupture is a fatal complication after myocardial infarction (MI). However, the detailed mechanism underlying cardiac rupture after MI remains to be fully elucidated. In this study, we investigated the role of mitochondrial DNA (mtDNA) and mitochondria in the pathophysiology of cardiac rupture by analyzing Twinkle helicase overexpression mice (TW mice). Twinkle overexpression increased mtDNA copy number approximately twofold and ameliorated ischemic cardiomyopathy at day 28 after MI. Notably, Twinkle overexpression markedly prevented cardiac rupture and improved post-MI survival, accompanied by the suppression of MMP-2 and MMP-9 in the MI border area at day 5 after MI when cardiac rupture frequently occurs...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
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