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https://www.readbyqxmd.com/read/29907260/usefulness-of-the-twinkling-artifact-on-doppler-ultrasound-for-the-detection-of-breast-microcalcifications
#1
A Relea, J A Alonso, M González, C Zornoza, S Bahamonde, B E Viñuela, M B Encinas
OBJECTIVE: To determine whether the twinkling artifact on Doppler ultrasound imaging corresponds to microcalcifications previously seen on mammograms and to evaluate the usefulness of this finding in the ultrasound management of suspicious microcalcifications. MATERIAL AND METHODS: We used ultrasonography to prospectively examine 46 consecutive patients with groups of microcalcifications suspicious for malignancy identified at mammography, searching for the presence of the twinkling artifact to identify the microcalcifications...
June 12, 2018: Radiología
https://www.readbyqxmd.com/read/29879750/artifacts-in-sonography-part-3
#2
Jörg A Bönhof, Glen McLaughlin
As a continuation of parts 1 1 and 2 2, this article discusses artifacts as caused by insufficient temporal resolution, artifacts in color and spectral Doppler sonography, and information regarding artifacts in sonography with contrast agents. There are artifacts that occur in B-mode sonography as well as in Doppler imaging methods and sonography with contrast agents, such as slice thickness artifacts and bow artifacts, shadows, mirroring, and artifacts due to refraction that appear, for example, as double images, because they are based on the same formation mechanisms...
June 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29770771/the-usefulness-of-agent-emission-imaging-high-mechanical-index-ultrasound-mode-in-the-diagnosis-of-urolithiasis-a-prospective-preliminary-study
#3
Artur Salmaslıoğlu, Mesut Bulakçı, Barış Bakır, Ravza Yılmaz, Yunus Emre Akpınar, Tzevat Tefik, Öner Şanlı, Sevda Özel, Bülent Acunas
PURPOSE: We aimed to determine the feasibility and effectiveness of agent emission imaging - high mechanical index (AEI-High MI) mode ultrasonography (US) compared with gray-scale and color Doppler US, alone or in combination, for the diagnosis of urolithiasis with reference to unenhanced computed tomography (CT). METHODS: This prospective study included 72 consecutive patients (40 males, 32 females; mean age, 45.9±14.7 years) referred by the department of urology for acute or elective symptoms of urolithiasis and confirmed to have urinary calculi on unenhanced abdominal CT, between January 2015 and June 2015...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29745022/restoring-mitochondrial-dna-copy-number-preserves-mitochondrial-function-and-delays-vascular-aging-in-mice
#4
Kirsty Foote, Johannes Reinhold, Emma P K Yu, Nichola L Figg, Alison Finigan, Michael P Murphy, Martin R Bennett
Aging is the largest risk factor for cardiovascular disease, yet the molecular mechanisms underlying vascular aging remain unclear. Mitochondrial DNA (mtDNA) damage is linked to aging, but whether mtDNA damage or mitochondrial dysfunction is present and directly promotes vascular aging is unknown. Furthermore, mechanistic studies in mice are severely hampered by long study times and lack of sensitive, repeatable and reproducible parameters of arterial aging at standardized early time points. We examined the time course of multiple invasive and noninvasive arterial physiological parameters and structural changes of arterial aging in mice, how aging affects vessel mitochondrial function, and the effects of gain or loss of mitochondrial function on vascular aging...
May 9, 2018: Aging Cell
https://www.readbyqxmd.com/read/29718319/characterization-of-the-nile-grass-rat-as-a-unique-model-for-type-2-diabetic-polyneuropathy
#5
Jyoti Singh, Muhammad Saad Yousuf, Kelvin E Jones, Paige T M Shelemey, Twinkle Joy, Haecy Macandili, Bradley J Kerr, Douglas W Zochodne, Yves Sauvé, Klaus Ballanyi, Christine A Webber
Type 2 diabetes (T2D) has reached pandemic proportions worldwide. Almost half of T2D patients suffer from polyneuropathy that can present as paresthesia, hyperalgesia, allodynia, or hypoesthesia. Therapeutic treatment options are largely incomplete, suggesting new avenues of research are needed. Herein, we introduce the African Nile Grass rat (NGR), which develops T2D solely by diet manipulation, as a novel T2D polyneuropathy model. The purpose of this study was to first characterize T2D-induced polyneuropathy in the NGRs before highlighting their strength as a potential prediabetic model of T2D...
April 28, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29580153/peripheral-nerve-injury-increases-contribution-of-l-type-calcium-channels-to-synaptic-transmission-in-spinal-lamina-ii-role-of-%C3%AE-2%C3%AE-1-subunits
#6
Sascha Ra Alles, Esperanza Garcia, Sridhar Balasubramanyan, Karen Jones, John R Tyson, Twinkle Joy, Terrance P Snutch, Peter A Smith
Background Following peripheral nerve chronic constriction injury, the accumulation of the α2δ-1 auxiliary subunit of voltage-gated Ca2+ channels in primary afferent terminals contributes to the onset of neuropathic pain. Overexpression of α2δ-1 in Xenopus oocytes increases the opening properties of Cav 1.2 L-type channels and allows Ca2+ influx at physiological membrane potentials. We therefore posited that L-type channels play a role in neurotransmitter release in the superficial dorsal horn in the chronic constriction injury model of neuropathic pain...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29549975/color-doppler-twinkling-artifact-in-diagnosis-of-tuberculous-pleuritis-a-comparison-with-gray-scale-ultrasonography-and-computed-tomography
#7
Jiakai Tian, Liang Xu
The aim of this study was to determine whether twinkling artifact (TA) detected on color Doppler ultrasonography can effectively determine the presence of pleural calcification compared with computed tomography (CT) and differentiate tuberculous pleuritis (TP) and cancerous pleuritis (CP). One hundred six cases of TP and 26 cases of CP were scanned using gray-scale ultrasonography (GSU) and TA to determine the presence of pleural calcification. With CT as the reference standard, 63.3% and 79.6% of patients with pleural calcification were identified with GSU and TA, respectively...
June 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29531434/metabolic-syndrome-among-adults-of-surendranagar-district-of-saurashtra-gujarat-a-cross-sectional-study
#8
Chaitanya Gopalrao Chinawale, Dipak V Parmar, Parth Kavathia, Twinkle Rangnani, Jainy Thakkar, Girija Kartha
Background: The metabolic syndrome (MetS) is a complex disorder and a major health concern in developing countries. Data on MetS in Indian population show multiplicity. There are no published reports about the prevalence of MetS in population of Saurashtra region, Gujarat. The aim of this study is to assess the prevalence of MetS and its components in adult population of this region. Methods: This cross-sectional observational study was carried out among 473 participants who attended free health checkup camps...
January 2018: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29456960/evaluation-and-customization-of-who-safety-checklist-for-patient-safety-in-otorhinolaryngology
#9
Yogesh Dabholkar, Haritosh Velankar, Sneha Suryanarayan, Twinkle Y Dabholkar, Akanksha A Saberwal, Bhavika Verma
The WHO has designed a safe surgery checklist to enhance communication and awareness of patient safety during surgery and to minimise complications. WHO recommends that the check-list be evaluated and customised by end users as a tool to promote safe surgery. The aim of present study was to evaluate the impact of WHO safety checklist on patient safety awareness in otorhinolaryngology and to customise it for the speciality. A prospective structured questionnaire based study was done in ENT operating room for duration of 1 month each for cases, before and after implementation of safe surgery checklist...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29448421/cross-diffusion-induced-subharmonic-spatial-resonances-in-a-predator-prey-system
#10
G Gambino, M C Lombardo, M Sammartino
In this paper we investigate the complex dynamics originated by a cross-diffusion-induced subharmonic destabilization of the fundamental subcritical Turing mode in a predator-prey reaction-diffusion system. The model we consider consists of a two-species Lotka-Volterra system with linear diffusion and a nonlinear cross-diffusion term in the predator equation. The taxis term in the search strategy of the predator is responsible for the onset of complex dynamics. In fact, our model does not exhibit any Hopf or wave instability, and on the basis of the linear analysis one should only expect stationary patterns; nevertheless, the presence of the nonlinear cross-diffusion term is able to induce a secondary instability: due to a subharmonic spatial resonance, the stationary primary branch bifurcates to an out-of-phase oscillating solution...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29436788/universal-scientific-education-and-research-network-usern-twinkling-stars-unite-to-make-the-world-glow
#11
Nima Rezaei
No abstract text is available yet for this article.
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29302033/loss-of-mtdna-activates-astrocytes-and-leads-to-spongiotic-encephalopathy
#12
Olesia Ignatenko, Dmitri Chilov, Ilse Paetau, Elena de Miguel, Christopher B Jackson, Gabrielle Capin, Anders Paetau, Mugen Terzioglu, Liliya Euro, Anu Suomalainen
Mitochondrial dysfunction manifests as different neurological diseases, but the mechanisms underlying the clinical variability remain poorly understood. To clarify whether different brain cells have differential sensitivity to mitochondrial dysfunction, we induced mitochondrial DNA (mtDNA) depletion in either neurons or astrocytes of mice, by inactivating Twinkle (TwKO), the replicative mtDNA helicase. Here we show that astrocytes, the most abundant cerebral cell type, are chronically activated upon mtDNA loss, leading to early-onset spongiotic degeneration of brain parenchyma, microgliosis and secondary neurodegeneration...
January 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29248029/the-value-of-the-twinkling-artefact-for-the-diagnosis-of-sialolithiasis-of-the-large-salivary-glands
#13
G Pabst, K Strobel, J Zehnder
OBJECTIVE: The imaging of stones in the salivary glands and ducts poses a challenge, even to experienced ultrasound examiners. This study investigated whether the 'twinkling artefact', which occurs at internal calcific foci during Doppler ultrasound examinations, is useful for detecting salivary gland stones. METHODS: In a model test, 20 salivary stones were analysed in vitro, via Doppler ultrasound, with regard to their representability and the triggering of the twinkling artefact...
February 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29225880/tumor-lysis-syndrome-with-massive-hyperphosphatemia-and-hyperuricemia
#14
Abhilash Koratala
Tumor lysis syndrome (TLS) occurs when tumor cells release their contents into the bloodstream, typically in response to chemotherapy, leading to the characteristic findings of hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and acute kidney injury. Twinkle artifacts on renal ultrasound may indicate calcium phosphate deposits in such patients.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29158291/rad51c-xrcc3-facilitates-mitochondrial-dna-replication-and-maintains-integrity-of-the-mitochondrial-genome
#15
Anup Mishra, Sneha Saxena, Anjali Kaushal, Ganesh Nagaraju
Mechanisms underlying mitochondrial genome maintenance have recently gained wide attention, as mutations in mitochondrial DNA (mtDNA) lead to inherited muscular and neurological diseases, which are linked to aging and cancer. It was previously reported that human RAD51, RAD51C, and XRCC3 localize to mitochondria upon oxidative stress and are required for the maintenance of mtDNA stability. Since RAD51 and RAD51 paralogs are spontaneously imported into mitochondria, their precise role in mtDNA maintenance under unperturbed conditions remains elusive...
February 1, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29131810/the-role-of-trapped-bubbles-in-kidney-stone-detection-with-the-color-doppler-ultrasound-twinkling-artifact
#16
Julianna C Simon, Oleg A Sapozhnikov, Wayne Kreider, Michael Breshock, James C Williams, Michael R Bailey
The color Doppler ultrasound twinkling artifact, which highlights kidney stones with rapidly changing color, has the potential to improve stone detection; however, its inconsistent appearance has limited its clinical utility. Recently, it was proposed stable crevice bubbles on the kidney stone surface cause twinkling; however, the hypothesis is not fully accepted because the bubbles have not been directly observed. In this paper, the micron or submicron-sized bubbles predicted by the crevice bubble hypothesis are enlarged in kidney stones of five primary compositions by exposure to acoustic rarefaction pulses or hypobaric static pressures in order to simultaneously capture their appearance by high-speed photography and ultrasound imaging...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28970293/mitochondrial-respiration-is-reduced-in-atherosclerosis-promoting-necrotic-core-formation-and-reducing-relative-fibrous-cap-thickness
#17
Emma P K Yu, Johannes Reinhold, Haixiang Yu, Lakshi Starks, Anna K Uryga, Kirsty Foote, Alison Finigan, Nichola Figg, Yuh-Fen Pung, Angela Logan, Michael P Murphy, Martin Bennett
OBJECTIVE: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving mitochondrial respiration affects plaque burden or composition are unclear. We examined mitochondrial respiration in human atherosclerotic plaques and whether augmenting mitochondrial respiration affects atherogenesis. APPROACH AND RESULTS: Human atherosclerotic plaques showed marked mitochondrial dysfunction, manifested as reduced mtDNA copy number and oxygen consumption rate in fibrous cap and core regions...
December 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28867657/imbalance-of-mitochondrial-respiratory-chain-complexes-in-the-epidermis-induces-severe-skin-inflammation
#18
Daniela Weiland, Bent Brachvogel, Hue-Tran Hornig-Do, Johannes F G Neuhaus, Tatjana Holzer, Desmond J Tobin, Carien M Niessen, Rudolf J Wiesner, Olivier R Baris
Accumulation of large-scale mitochondrial DNA (mtDNA) deletions and chronic, subclinical inflammation are concomitant during skin aging, thus raising the question of a causal link. To approach this, we generated mice expressing a mutant mitochondrial helicase (K320E-TWINKLE) in the epidermis to accelerate the accumulation of mtDNA deletions in this skin compartment. Mice displayed low amounts of large-scale deletions and a dramatic depletion of mtDNA in the epidermis and showed macroscopic signs of severe skin inflammation...
January 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28845492/twinkle-twinkle-little-stone-an-artifact-improves-the-ultrasound-performance
#19
Mirela Liana Gliga, Cristian Nicolae Chirila, Daniela Maria Podeanu, Torok Imola, Sanda Lucia Voicu, Mihail Gheorghe Gliga, Paula Maria Gliga
AIMS: Ultrasound is a noninvasive method used for the diagnosis of urinary lithiasis. When the length of the stone is less than 5 mm, its detection may be difficult. The twinkling artifact (TwA) is an intense alternating color signal behind calcifications and stones in different organs. The aim of this paper was to evaluate the importance of the TwA in detecting kidney stones less than 5 mm in length. MATERIAL AND METHODS: We examined 230 patients with lumbar pain or a history of kidney stones...
June 17, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28769029/loss-of-succinyl-coa-synthase-adp-forming-%C3%AE-subunit-disrupts-mtdna-stability-and-mitochondrial-dynamics-in-neurons
#20
Yujun Zhao, Jing Tian, Shaomei Sui, Xiaodong Yuan, Hao Chen, Chuanqiang Qu, Yifeng Du, Lan Guo, Heng Du
Succinyl Coenzyme A synthetase (SCS) is a key mitochondrial enzyme. Defected SCS ADP-forming β subunit (SCS A-β) is linked to lethal infantile Leigh or leigh-like syndrome. However, the impacts of SCS A-β deficiency on mitochondria specifically in neurons have not yet been comprehensively investigated. Here, by down-regulating the expression levels of SCS A-β in cultured mouse neurons, we have found that SCS A-β deficiency induces severe mitochondrial dysfunction including lowered oxidative phosphorylation (OXPHOS) efficiency, increased mitochondrial superoxide production, and mtDNA depletion as well as aberrations of mitochondrial fusion and fission proteins, which eventually leads to neuronal stress...
August 2, 2017: Scientific Reports
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