keyword
https://read.qxmd.com/read/38495191/magnetic-stirring-in-syringe-dispersive-liquid-liquid-microextraction-as-an-effective-method-for-preconcentration-of-tartrazine-dye-from-food-samples-a-multivariate-analysis-approach
#1
JOURNAL ARTICLE
Ali Mohammadzadeh, Mahboobeh Amiri
A new, rapid, simple, and sensitive preconcentration method and Spectrophotometry determination technique have been presented for the microextraction and determination of trace amount of Tartrazine dye in food samples. In the present system, which is called "Magnetic stirring in syring dispersive liquid-liquid microextraction"(MSIS- DLLME), a cloudy state result is formed in a homemade glass syringe by magnetic agitation. In the MSIS-DLLME system, Tartrazine colour was uprooted into an organic detergent (Toluene) after many twinkles...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38469012/acute-necrotizing-pancreatitis-presenting-as-gastrocolic-fistula-a-rare-occurrence
#2
Twinkle Pawar, Harshitha Reddy, Sunil Kumar, Sourya Acharya, Vijendra Kirnake
Tissue necrosis and ischemia are hallmarks of acute necrotizing pancreatitis, which frequently results in fatal infections. In this case, we describe a man in his 40s who had diffuse pain in the abdomen, intractable vomiting, diarrhoea, and intermittent fever. His abdominal computed tomography revealed acute pancreatitis with peripancreatic fluid collection, gastric perforation, and fistula formation between the greater curvature of the stomach and transverse colon. His upper gastrointestinal (GI) endoscopy confirmed a gastrocolic fistula...
February 2024: Curēus
https://read.qxmd.com/read/38447359/do-toddlers-reason-about-other-people-s-experiences-of-objects-a-limit-to-early-mental-state-reasoning
#3
JOURNAL ARTICLE
Brandon M Woo, Gabriel H Chisholm, Elizabeth S Spelke
Human social life requires an understanding of the mental states of one's social partners. Two people who look at the same objects often experience them differently, as a twinkling light or a planet, a 6 or a 9, and a random cat or Cleo, their pet. Indeed, a primary purpose of communication is to share distinctive experiences of objects or events. Here, we test whether toddlers (14-15 months) are sensitive to another agent's distinctive experiences of pictures when determining the goal underlying the agent's actions in a minimally social context...
March 5, 2024: Cognition
https://read.qxmd.com/read/38425963/no-child-s-play-under-five-child-feces-management-in-a-rural-area-of-bengaluru-urban-district-india
#4
JOURNAL ARTICLE
Anissa Mary Thomas Thattil, Twinkle Agrawal, Abdul Kader Surti, Stallon Sebastian, Kiyana Mirza, George Jacob, Farah Naaz Fathima
BACKGROUND: Inappropriate feces disposal leads to environmental contamination, and increases the risk of exposure to children. We aimed to estimate the proportion of rural households with knowledge and practice of safe management of feces (SMoF) among under-five children and to identify associated factors. MATERIALS AND METHODS: A cross-sectional study was conducted in eight villages in Bengaluru Urban district over 2 months, using a face-validated semi-structured interview schedule...
2024: Indian Journal of Community Medicine
https://read.qxmd.com/read/38358061/engineered-tumor-immune-microenvironment-on-a-chip-to-study-t-cell-macrophage-interaction-in-breast-cancer-progression
#5
JOURNAL ARTICLE
Twinkle Jina Minette Manoharan, Kalpana Ravi, Abhirami P Suresh, Abhinav P Acharya, Mehdi Nikkhah
Evolving knowledge about the Tumor Immune Microenvironment (TIME) is driving innovation in designing novel therapies against hard-to-treat breast cancer. Targeting the immune components of TIME has emerged as a promising approach for cancer therapy. While recent immunotherapies aim at restoring antitumor immunity, counteracting tumor escape remains challenging. Hence there is a pressing need to better understand the complex tumor-immune crosstalk within TIME. Considering this imperative, this study aimed at investigating the crosstalk between the two abundant immune cell populations within the breast TIME - macrophages and T cells, in driving tumor progression using an organotypic 3D in vitro tumor on-a-chip (TOC) model...
February 15, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38331697/using-3-d-printed-structures-to-evaluate-the-potential-causes-of-the-color-doppler-twinkling-signature
#6
JOURNAL ARTICLE
Benjamin G Wood, Renc Saracaydin, Seth A Hara, Christine U Lee, Matthew W Urban
OBJECTIVE: The color Doppler twinkling artifact has been attributed to existing microbubbles or cavitation occurring on rough objects such as kidney stones, some breast biopsy clips, catheter guidewires and sandpaper. The objective was to investigate the correlation between the surface characteristics of helical constructs with different groove geometries and the occurrence of twinkling, as well as to identify locations conducive to bubble retention and/or cavitation. METHODS: Six half-cylinders were created with a microscale 3-D printer with 5 µm resolution to replicate the geometry of twinkling helical constructs resembling catheter guidewires...
February 7, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38314561/barriers-to-enrollment-in-a-post-stroke-neuromodulation-and-walking-study-implications-for-recruiting-women
#7
JOURNAL ARTICLE
Twinkle Mehta, Brice Cleland, Sangeetha Madhavan
BACKGROUND: Women have a higher risk of stroke and related disability than men but are underrepresented in stroke clinical trials. Identifying modifiable recruitment and enrollment barriers for women can improve study generalizability, statistical power, and resource utilization. OBJECTIVE: In a post-stroke neuromodulation study, we determined the impact of sex on the occurrence of exclusion criteria and compared the sex distribution of screened and enrolled individuals with a broader stroke-affected population...
February 5, 2024: Neurorehabilitation and Neural Repair
https://read.qxmd.com/read/38147743/engineered-3d-ex-vivo-models-to-recapitulate-the-complex-stromal-and-immune-interactions-within-the-tumor-microenvironment
#8
REVIEW
Kalpana Ravi, Twinkle Jina Minette Manoharan, Kuei-Chun Wang, Barbara Pockaj, Mehdi Nikkhah
Cancer thrives in a complex environment where interactions between cellular and acellular components, surrounding the tumor, play a crucial role in disease development and progression. Despite significant progress in cancer research, the mechanism driving tumor growth and therapeutic outcomes remains elusive. Two-dimensional (2D) cell culture assays and in vivo animal models are commonly used in cancer research and therapeutic testing. However, these models suffer from numerous shortcomings including lack of key features of the tumor microenvironment (TME) & cellular composition, cost, and ethical clearance...
December 19, 2023: Biomaterials
https://read.qxmd.com/read/38127181/tartrate-dehydrogenase-in-bacillus-species-deciphering-unique-catalytic-diversity-through-kinetic-structural-and-molecular-docking-analysis
#9
JOURNAL ARTICLE
Manali Chandnani, Disha Patel, Twinkle Patel, Aditi Buch
Divergently evolved Tartrate dehydrogenase (TDH) exhibits multiple catalytic activities at a single active site; the enzyme from P. putida (pTDH) being structurally and biochemically well-characterized. Occurrence of TDH-associated ability to aerobically metabolize L-tartrate in Bacillus isolates and limited resemblance of ycsA-encoded protein sequences with pTDH rendered Bacillus TDH as an intriguing enzyme with possible catalytic diversity as well as evolutionary significance. The present study explores substrate interactions of TDHs from B...
December 21, 2023: Protein Journal
https://read.qxmd.com/read/38099171/twinkle-artifact-observed-during-pocus-of-a-human-myiasis-caused-by-the-dermatobia-hominis-botfly
#10
David Jerome, Matthew Stacey, Joseph Newbigging
An 81-year-old man presented to urgent care for assessment of an area of erythema and tenderness on his right thigh after recent travel to Belize. Point of care ultrasound (POCUS) revealed a hyperechoic structure with acoustic shadowing in the subcutaneous tissue. Colour Doppler assessment of the structure produced a twinkle artifact. The structure was removed and pathology identified the object as a Dermatobia hominis larva (human botfly). The use of POCUS helped identify and localize the subcutaneous foreign body...
2023: POCUS J
https://read.qxmd.com/read/38050518/reducing-stress-and-anxiety-in-first-year-undergraduates-through-biofeedback-assisted-relaxation-training
#11
JOURNAL ARTICLE
V R Abhinaya Ravada, Kakarla V M Sai Lahari, Havilah Twinkle Reddipogu, Lakshmi Prasanna Vuyyuru, Chandana Konda, Mohammed Jaffer Pinjar
Background :  College students face many stressors daily, often resulting in psychological challenges such as heightened anxiety and depression. Biofeedback is becoming aware of and learning to modify the body's physiological functions. This study aimed to evaluate the efficacy of biofeedback relaxation training in mitigating stress and anxiety levels among medical undergraduates. Methods :  This pretest-posttest control group design study was conducted following the ethics committee's approval. The study selected first-year MBBS students based on their elevated stress and anxiety scores and divided them into intervention and control groups...
November 2023: Curēus
https://read.qxmd.com/read/38045786/could-twinkling-artifact-be-a-parameter-in-predicting-the-success-of-shock-wave-lithotripsy-a-prospective-study
#12
JOURNAL ARTICLE
Mehmet Sevim, Okan Alkis, İbrahim Güven Kartal, Huseyin Ozgur Kazan, Oguzhan Yusuf Sonmez, Mehmet Korkmaz, Bekir Aras
INTRODUCTION: It is important to predict success before the treatment of urolithiasis. We aimed to predict the success of shock wave lithotripsy (SWL) by comparing twinkling artifact (TA) revealed through colour Doppler ultrasonography (CDUS) with stone density in non-contrast computed tomography (NCCT). MATERIAL AND METHODS: Eighty patients who underwent SWL between January 2021 and January 2022 were included in the study. Patients with stones of 5-20 mm in the renal pelvis and proximal ureter at NCCT were included...
2023: Central European Journal of Urology
https://read.qxmd.com/read/38013441/a-comprehensive-review-on-nanoparticles-as-a-targeted-delivery-system-for-the-treatment-of-lung-cancer
#13
JOURNAL ARTICLE
Twinkle Gupta, Avinash Varanwal, Priyanshu Nema, Sakshi Soni, Arun K Iyer, Ratnesh Das, Vandana Soni, Sushil K Kashaw
The second most common type of cancer is lung cancer, impacting the human population. Lung cancer is treated with a number of surgical and non-surgical therapies, including radiation, chemotherapy, and photodynamic treatment. However, the bulk of these procedures are costly, difficult, and hostile to patients. Chemotherapy is distinguished by inadequate tumour targeting, low drug solubility, and insufficient drug transport to the tumour site. In order to deal with the issues related to chemotherapy, extensive efforts are underway to develop and investigate various types of nanoparticles, both organic and inorganic, for the treatment of lung cancer...
November 27, 2023: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/37991465/effect-of-ambient-gas-and-crystal-features-on-doppler-ultrasound-twinkling-of-pathological-mineralizations
#14
JOURNAL ARTICLE
Eric Rokni, Julianna C Simon
Color Doppler twinkling on kidney stones and other pathological mineralizations is theorized to arise from stable microbubbles, which suggests twinkling will be sensitive to ambient gas. Here, lab-grown cholesterol, calcium phosphate, and uric acid crystals were imaged with ultrasound in water while varying oxygen, carbon dioxide, and nitrogen levels. Twinkling was found to increase on cholesterol in elevated oxygen, cholesterol and calcium phosphate in elevated carbon dioxide, and no crystals in elevated nitrogen...
November 1, 2023: Journal of the Acoustical Society of America
https://read.qxmd.com/read/37987986/sex-differences-in-thrombin-generation-in-patients-with-acute-ischemic-stroke
#15
JOURNAL ARTICLE
Sarina Falcione, Elena Spronk, Danielle Munsterman, Twinkle Joy, Roobina Boghozian, Glen C Jickling
Sex differences in stroke exist, including variation in stroke risk and outcome. Differences in thrombin generation may contribute to this variation between females and males. To examine this, we assessed sex differences in thrombin generation between females and males with acute ischemic stroke and the relationship to blood cell gene expression. In 97 patients with acute ischemic stroke, thrombin generation was measured by thrombin generation assay. Blood cell gene expression was measured by microarray. Differences in thrombin generation between sexes were identified and the relationship to blood cell gene expression examined...
November 21, 2023: Translational Stroke Research
https://read.qxmd.com/read/37984700/use-of-closed-system-transfer-devices-cstds-with-protein-based-therapeutic-drugs-a-non-solution-for-a-non-problem
#16
JOURNAL ARTICLE
Fast Jonas, Christian Twinkle, Crul Mirjam, Jiskoot Wim, NejadnikM Reza, Medina Annette, Radwick Allison, Sreedhara Alavattam, Tole Hugh
No abstract text is available yet for this article.
November 18, 2023: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/37967089/randomised-controlled-trial-to-compare-efficacy-of-standard-care-alone-and-in-combination-with-homoeopathic-treatment-of-moderate-severe-covid-19-cases
#17
JOURNAL ARTICLE
Harleen Kaur, Ramesh Bawaskar, Akash Khobragade, Dhiraj Kalra, Vedati Packiam, Mohammed Yamin Khan, Twinkle Kaur, Manish Sharma, Naval Kumar Verma, Subhash Kaushik, Anil Khurana
BACKGROUND & OBJECTIVES: No definite treatment is known for COVID-19 till date. The objective of this study is to assess the efficacy of customized Homoeopathic medicines, when used as an add-on treatment to Standard of Care (SOC), in patients suffering from moderate to severe COVID-19 infection. METHODS: This was a randomized, controlled, single-blind, parallel-group trial where 214 COVID19-positive patients were screened for moderate and severe cases of COVID-19...
2023: PloS One
https://read.qxmd.com/read/37956573/development-and-content-validation-of-yoga-module-for-the-mental-health-of-nicu-mothers
#18
JOURNAL ARTICLE
Twinkle Dogra, Kavita Khoiwal, Jaya Chaturvedi, Vikas Upadhyay, Suresh Lal Barnwal, Ajeet Singh Bhadoria, Poonam Singh
BACKGROUND: Postnatal yoga has been found to be effective for maternal mental health management. But a validated yoga module for the mental health of early postpartum mothers with infants admitted to the Neonatal Intensive Care Unit (NICU) is lacking. AIM: To design and validate a yoga module for the mental health of early postpartum mothers having infants admitted to the NICU. MATERIALS AND METHODS: First phase: A yoga module was designed through a review of published research articles and yogic texts for NICU mothers...
October 31, 2023: Midwifery
https://read.qxmd.com/read/37952242/maxillary-sinus-in-gender-determination-a-morphometric-analysis-using-cone-beam-computed-tomography
#19
JOURNAL ARTICLE
Arathi Kannampurath, Sreela Leela Srikantannair, Philips Mathew, Twinkle SivaPrasad
Gender determination of skeletal remains is an important forensic procedure in the identification process. Maxillary sinus remains intact even when the skull and other bones may be badly disfigured. Cone beam computed tomography (CBCT) can provide precise information about complex anatomical structures, as it is characterized by rapid volumetric image acquisition with high resolution. The present study aimed to assess the accuracy of maxillary sinus measurements using cone beam computed tomography in gender determination and to develop a formula using discriminate function analysis...
November 12, 2023: Forensic Science, Medicine, and Pathology
https://read.qxmd.com/read/37917930/twinkle-catalyzed-toehold-mediated-dna-strand-displacement-reaction
#20
JOURNAL ARTICLE
Anupam Singh, Gayatri Patel, Smita S Patel
Strand exchange between homologous nucleic acid sequences is the basis for cellular DNA repair, recombination, and genome editing technologies. Specialized enzymes catalyze cellular strand exchange; however, the reaction occurs spontaneously when a single-stranded DNA toehold can dock the invader strand on the target DNA to initiate strand exchange through branch migration. Due to its precise response, the spontaneous toehold-mediated strand displacement (TMSD) reaction is widely employed in DNA nanotechnology...
November 2, 2023: Journal of the American Chemical Society
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