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https://www.readbyqxmd.com/read/29913529/a-pilot-study-evaluating-cerebral-vasculitis-in-kawasaki-s-disease
#1
Jung Sook Yeom, Young Hye Cho, Chung Mo Koo, Jin Su Jun, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Cerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD ( n  = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [ n  = 5], enteroviral meningitis [ n  = 10], nonspecific viral illness without central nervous system involvement [ n  = 10])...
June 18, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29913416/contaminant-mixtures-interact-to-impair-predator-avoidance-behaviours-and-survival-in-a-larval-amphibian
#2
Michael Sievers, Robin Hale, Stephen E Swearer, Kirsten M Parris
Global declines in amphibian populations are a significant conservation concern, and environmental contamination is likely a contributing driver. Although direct toxicity may be partly responsible, contaminants are often present at sub-lethal concentrations in the wild. Behavioural end-points are becoming an increasingly useful method to estimate the impact of contaminants, particularly if the behavioural responses manifest to affect individual fitness (i.e. survival, growth, or reproduction). In the wild, most animals are affected by multiple stressors, and determining how these interact to affect behaviour is critical for understanding the ecological implications of contaminant exposure...
June 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29913295/comparison-of-the-effects-of-contractubex%C3%A2-gel-and-benzothiazole-after-topical-application-in-an-experimental-model-of-epidural-fibrosis-in-rats
#3
Huseyin Bozkurt, Emel Cicek Bozkurt, Hulya Ozpinar, Densel Arac, Ismail Kaya, Hidir Ozer, Reyhan Egilmez
OBJECTIVE: Postoperative epidural adhesion is one of the most frequent causes of failed-back surgery syndrome, presenting with back and leg pain or neurological deficits. Development of preventive measures for epidural adhesion after laminectomy remains critical to improve the outcomes of lumbar surgery. We hypothesized that positive effects of the topical application of Contractubex®Gel and benzothiazole individually and in combination can aid in the prevention of epidural fibrosis in a rat laminectomy model...
June 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29913269/iliac-screw-for-reconstructing-posterior-pelvic-ring-in-tile-type-c1-pelvic-fractures
#4
Yonggang Li, Xiguang Sang, Zhiyong Wang, Lin Cheng, Hao Liu, Tao Qin, Kai Di
BACKGROUND: It is often difficult to achieve stable fixation in Tile type C1 pelvic fractures and there is no standard fixation technique for these types of injuries. HYPOTHESIS: Iliac screw fixation can be used for treating Type C1 pelvic fractures. PATIENTS AND METHODS: A retrospective review was performed on 47 patients who underwent iliac screw fixation in posterior column of ilium (PCI) for Tile type C1 pelvic fractures from July 2007 to December 2014...
June 15, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29913220/nootropic-nanocomplex-with-enhanced-blood-brain-barrier-permeability-for-treatment-of-traumatic-brain-injury-associated-neurodegeneration
#5
REVIEW
Jeongmin Park, Eunshil Choi, Seulgi Shin, Sungsu Lim, Dohee Kim, Suji Baek, Kang Pa Lee, Jae Jun Lee, Byeong Han Lee, Bokyung Kim, Keunsoo Jeong, Ja-Hyun Baik, Yun Kyung Kim, Sehoon Kim
Traumatic brain injury (TBI) is an intracranial injury which can induce immediate neuroinflammation and long-term neurological deficits. Methylene blue (MB) as a nootropic has a great potential to treat neurodegeneration after TBI because of its anti-inflmmatory and neuroprotective functions. However, its limited accumulation to the brain across the blood-brain barrier (BBB) remains a major hurdle to be overcome. In this paper, we present a polymer surfactant-encapsulated nanocomplex of MB as a delivery system with high BBB permeability for efficacious treatment of TBI-induced neurodegeneration...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29913137/memantine-rescues-prenatal-citalopram-exposure-induced-striatal-and-social-abnormalities-in-mice
#6
Aqeela Zahra, Jinxiang Jiang, Yunan Chen, Cheng Long, Li Yang
Prenatal exposure to citalopram (CTM), an antidepressant drug, has been associated with altered behavior, including autism-like symptoms in both human and rodent offspring. However, the neurological basis underlying these abnormal behaviors is not well understood. Here, we examined behavioral, morphological, and biochemical alterations in the male and female offspring of C57BL/6 mouse mothers that had been exposed to CTM during the last trimester of gestation. We observed abnormal behavior such as anxiety, altered locomotion and disordered social interactions in 2-5 month old offspring with prenatal CTM exposure...
June 15, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29913083/risk-factors-for-recurrent-neurotrauma-a-population-based-study-in-southeastern-michigan
#7
R David Hayward, Mary M Fessler, Joseph Buck, Richard D Fessler
INTRODUCTION: Studies have shown an increased risk of traumatic brain injury (TBI) for individuals who suffer an initial TBI. The current study hypothesized that individuals with recurrent neurotrauma would originate from populations considered 'vulnerable', i.e. low income and/or with psychiatric comorbidities. METHODS: Data from the Michigan State Inpatient Database from 2006 to 2014 for the Detroit metropolitan area enlisted a study population of 50 744 patients with neurotrauma...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29913031/four-year-survival-of-a-patient-with-spinal-metastatic-acinic-cell-carcinoma-after-a-total-en-bloc-spondylectomy-and-reconstruction-with-a-frozen-tumor-bearing-bone-graft
#8
Apiruk Sangsin, Hideki Murakami, Takaki Shimizu, Satoshi Kato, Hiroyuki Tsuchiya
Acinic cell carcinoma metastasizing to the spine is extremely rare. The authors present a case of acinic cell carcinoma of the parotid gland with subsequent lung and spinal metastases, treated with en bloc spondylectomy. A 41-year-old man presented with a left parotid mass. After being diagnosed with acinic cell carcinoma, he underwent a total parotidectomy. Imaging studies revealed a metastatic osteoblastic lesion in the T4 vertebral body and multiple lung metastases. Total en bloc spondylectomy and reconstruction with a frozen tumor-bearing bone graft were performed to treat the T4 metastasis...
June 18, 2018: Orthopedics
https://www.readbyqxmd.com/read/29913017/safety-and-tolerability-of-multiple-ascending-doses-of-prx002-rg7935-an-anti-%C3%AE-synuclein-monoclonal-antibody-in-patients-with-parkinson-disease-a-randomized-clinical-trial
#9
Joseph Jankovic, Ira Goodman, Beth Safirstein, Tonya K Marmon, Dale B Schenk, Martin Koller, Wagner Zago, Daniel K Ness, Sue G Griffith, Michael Grundman, Jay Soto, Susanne Ostrowitzki, Frank G Boess, Meret Martin-Facklam, Joseph F Quinn, Stuart H Isaacson, Omid Omidvar, Aaron Ellenbogen, Gene G Kinney
Importance: Aggregated α-synuclein is believed to be central to the pathogenesis of Parkinson disease (PD). PRX002/RG7935 (PRX002) is a humanized monoclonal antibody designed to target aggregated forms of α-synuclein, thereby inhibiting neuron-to-neuron transfer of presumed pathogenic forms of α-synuclein, potentially resulting in neuronal protection and slowing disease progression. Objective: To evaluate the safety and tolerability of multiple intravenous infusions of PRX002 in patients with idiopathic PD...
June 18, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29912800/neurological-deficits-after-lithium-intoxication-in-a-bipolar-woman-with-catatonia-treated-with-ect
#10
Pierpaolo Medda, Chiara Socci, Cristina Toni, Irene Pergentini, Francesco Forfori, Filippo Sean Giorgi, Giulio Perugi
No abstract text is available yet for this article.
June 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912724/selection-of-patients-recumbent-position-laterality-according-to-physician-handedness-bias-increases-the-success-rate-of-lumbar-puncture-a-multicenter-study
#11
Jian-Lan Zhao, Yi-Rui Sun, Qiao Shan, Zhi-Peng Xiao, Ben-Chao Hou, Jin Hu
BACKGROUND: Lumbar puncture (LP) is a medical procedure required during spinal anesthesia and for obtaining cerebrospinal fluid samples in the diagnosis of neurological disorders. The aim of this study was to assess the effects of physicians' handedness bias and the laterality of patients' recumbent position on the success rate of LPs. METHODS AND PATIENTS: A prospective multicenter study including 36 physicians (18 left-handed and 18 right-handed) and 7200 patients was conducted in 6 medical centers...
June 15, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29912686/diphtheria-outbreak-in-amerindian-communities-wonken-venezuela-2016-2017
#12
Adriana Lodeiro-Colatosti, Udo Reischl, Thomas Holzmann, Carlos E Hernández-Pereira, Alejandro Rísquez, Alberto E Paniz-Mondolfi
In February 2017, a diphtheria outbreak occurred among Amerindians of the Pemón ethnic group in Wonken, Venezuela. A field investigation revealed ≈10 cases; clinical presentation did not include cutaneous or neurologic signs or symptoms. To prevent future outbreaks in Venezuela, Amerindian communities need better access to vaccination and healthcare.
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912656/neurological-impairments-in-hypoxic-neonates-and-lactate-levels
#13
Miljana Z Jovandaric, Svetlana J Milenkovic
INTRODUCTION: Metabolic acidosis with increasing lactate concentration develops due to the lack of oxygen in the tissues. OBJECTIVES: The effect of lactic acidosis on neurological development in the first year of life. MATERIALS AND METHODS: Our study included 50 newborns with perinatal hypoxia requiring oxygen therapy and 50 healthy newborns. pH, pCO2, pO2, base excess (BE) and lactates from arterialized capillary blood were determined in both groups of newborns, in the first and second hours after birth, and neurological development in the first year of life was estimated...
June 18, 2018: Neurological Research
https://www.readbyqxmd.com/read/29912560/computational-modeling-and-validation-of-thermally-induced-electrical-capacitance-changes-for-lipid-bilayer-membranes-irradiated-by-pulsed-lasers
#14
Zahra Ebtehaj, Ali Hatef, Mohammad Malekmohammad, Mahmood Soltanolkotabi
Neural stimulation has widespread applications in investigating brain functions, restoring impaired neural functions and treating numerous neurological/psychiatric diseases. Using infrared pulses to stimulate neurons (Infrared Neural Stimulation, INS) offers a direct and noninvasive technique. Recent research has demonstrated that transient heating associated with the absorption of infrared light by the local aqueous medium around the cell membrane can stimulate nerves. One mechanism for this stimulation is due to a thermally induced increase in the membrane electrical capacitance which causes cell depolarization as well as action potential production under certain physiological conditions...
June 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29912447/body-structure-function-activity-and-participation-in-3-to-6-year-old-children-born-very-preterm-an-icf-based-systematic-review-and-meta-analysis
#15
Tara L FitzGerald, Amanda K L Kwong, Jeanie L Y Cheong, Jennifer L McGinley, Lex W Doyle, Alicia J Spittle
Background: The World Health Organization's International Classification of Functioning, Disability and Health framework, Children and Youth Version (ICF-CY), provides a valuable method of conceptualizing the multidomain difficulties experienced by children born very preterm (VP). Reviews investigating motor outcomes at preschool age across ICF-CY domains are lacking. Purpose: The purpose of this review is to identify and compare motor outcomes of 3- to 6-year-old children born VP and children born full term (FT) within the ICF-CY framework...
April 18, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29912432/transcatheter-aortic-valve-replacement-in-the-setting-of-left-atrial-appendage-thrombus
#16
Arash Salemi, Andrea De Micheli, Abdullah Aftab, Adham Elmously, Regis Chang, S Chiu Wong, Berhane M Worku
OBJECTIVES: Left atrial appendage thrombus (LAT) was an exclusion criterion in the seminal transcatheter aortic valve replacement (TAVR) trials; however, such patients do undergo TAVR in the 'real-world' setting. This study sought to analyse outcomes after TAVR in patients with LAT or spontaneous echo contrast (SEC). METHODS: All patients undergoing TAVR at our institution between March 2009 and December 2014 were prospectively analysed. The presence of LAT or SEC was determined via a retrospective chart review...
June 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29912426/experimental-infection-of-syrian-hamsters-with-aerosolized-nipah-virus
#17
Olivier Escaffre, Terence Hill, Tetsuro Ikegami, Terry L Juelich, Jennifer K Smith, Lihong Zhang, David E Perez, Colm Atkins, Arnold Park, William S Lawrence, Satheesh K Sivasubramani, Jennifer E Peel, Johnny W Peterson, Benhur Lee, Alexander N Freiberg
Background: Nipah virus (NiV) is a paramyxovirus (genus henipavirus) that can cause severe respiratory illness and encephalitis in humans. Transmission occurs through consumption of NiV-contaminated foods, and contact with NiV-infected animals or human body fluids. However, it is unclear whether aerosols derived from aforesaid sources or others also contribute to transmission, and current knowledge on NiV-induced pathogenicity after small particle aerosol exposure is still limited. Methods: infectivity, pathogenicity and real-time dissemination of aerosolized NiV in Syrian hamsters was evaluated using NiV-Malaysia (NiV-M) and/or its recombinant expressing firefly luciferase (rNiV-Fluc NP)...
June 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29912398/multicenter-investigation-of-channel-based-subcortical-trans-sulcal-exoscopic-resection-of-metastatic-brain-tumors-a-retrospective-case-series
#18
Joshua Bakhsheshian, Ben A Strickland, Christina Jackson, Kaisorn L Chaichana, Ronald Young, Gustavo Pradilla, Jefferson W Chen, Julian Bailes, Gabriel Zada
BACKGROUND: Recent advancements have aimed to optimize visualization and minimize insult to healthy cortical and subcortical tissue through the use of tubular-based retractors. OBJECTIVE: To investigate outcomes following resection of cerebral metastases using an integrated tubular retraction system with an exoscope and neuronavigation. METHODS: A multicenter retrospective analysis of surgical outcomes in consecutive patients who underwent resection of a brain metastasis using a tubular retraction system and exoscope was performed...
April 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29912324/foxg1-regulates-the-postnatal-development-of-cortical-interneurons
#19
Wei Shen, Ru Ba, Yan Su, Yang Ni, Dongsheng Chen, Wei Xie, Samuel J Pleasure, Chunjie Zhao
Abnormalities in cortical interneurons are closely associated with neurological diseases. Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of Foxg1 in the cortical interneuron development. Here, by conditional deletion of Foxg1, which was achieved by crossing Foxg1fl/fl with the Gad2-CreER line, we found the postnatal distributions of somatostatin-, calretinin-, and neuropeptide Y-positive interneurons in the cortex were impaired. Further investigations revealed an enhanced dendritic complexity and decreased migration capacity of Foxg1-deficient interneurons, accompanied by remarkable downregulation of Dlx1 and CXCR4...
April 18, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29912303/early-juvenile-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-study-of-25-patients
#20
Cinthya Maria Neves Varandas, José Lucas Sena da Silva, Janeusa Rita L Primo, Maria de Fátima S P de Oliveira, Otávio Moreno-Carvalho, Lourdes Farre, Achiléa L Bittencourt
Background: HTLV-1 may cause severe diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated to HTLV-1 (IDH). The clinical characteristics and progression of 25 early onset HAM/TSP associated or not to IDH were described. Methods: Following-up 37 IDH patients with neurological examinations, 54% developed HAM/TSP. To these cases were added five cases of juvenile HAM/TSP. The patients were HTLV-1+ and were submitted to dermatological and neurological examinations...
April 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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