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JOURNAL ARTICLE
Zeus Gracia-Tabuenca, Elise B Barbeau, Yu Xia, Xiaoqian Chai
Depression is an incapacitating psychiatric disorder with increased risk through adolescence. Among other factors, children with family history of depression have significantly higher risk of developing depression. Early identification of pre-adolescent children who are at risk of depression is crucial for early intervention and prevention. In this study, we used a large longitudinal sample from the Adolescent Brain Cognitive Development (ABCD) Study (2658 participants after imaging quality control, between 9-10 years at baseline), we applied advanced machine learning methods to predict depression risk at the two-year follow-up from the baseline assessment, using a set of comprehensive multimodal neuroimaging features derived from structural MRI, diffusion tensor imaging, and task and rest functional MRI...
April 8, 2024: NeuroImage: Clinical
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JOURNAL ARTICLE
Marie L Landry, Sajjad Hassan, Bruce G Rottmann, Stacey J Pesak, Michael Ordazzo, Michael Skrzyniarz, Steven Deponte, David R Peaper
UNLABELLED: We compared the performance of a new modified two-tier testing (MTTT) platform, the Diasorin Liaison chemiluminescent immunoassay (CLIA), to the Zeus enzyme-linked immunoassay (ELISA) MTTT and to Zeus ELISA/Viramed immunoblot standard two-tier testing (STTT) algorithm. Of 537 samples included in this study, 91 (16.9%) were positive or equivocal by one or more screening tests. Among these 91 samples, only 57 samples were concordant positive by first-tier screening tests, and only 19 of 57 were concordant by the three second-tier methods...
April 10, 2024: Journal of Clinical Microbiology
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JOURNAL ARTICLE
Houtan Heidari, Dominika Kanschik, Oliver Maier, Georg Wolff, Maximilian Brockmeyer, Maryna Masyuk, Raphael Romano Bruno, Amin Polzin, Ralf Erkens, Gerald Antoch, Sebastian Daniel Reinartz, Nikos Werner, Malte Kelm, Tobias Zeus, Shazia Afzal, Christian Jung
BACKGROUND: Understanding complex cardiac anatomy is essential for percutaneous left atrial appendage (LAA) closure. Conventional multi-slice computed tomography (MSCT) and transesophageal echocardiography (TEE) are now supported by advanced 3D printing and virtual reality (VR) techniques for three-dimensional visualization of volumetric data sets. This study aimed to investigate their added value for LAA closure procedures. METHODS: Ten patients scheduled for interventional LAA closure were evaluated with MSCT and TEE...
2024: Frontiers in Cardiovascular Medicine
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JOURNAL ARTICLE
Zeus Aranda
No abstract text is available yet for this article.
April 9, 2024: American Journal of Tropical Medicine and Hygiene
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REVIEW
Maurizio Bruschi, Andrea Angeletti, Marco Prunotto, Pier Luigi Meroni, Gian Marco Ghiggeri, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Andrea Cavalli, Leonardo Scapozza, Jigar J Patel, John C Tan, Ken C Lo, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Domenico Giannese, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Federica Bui, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Paride Fenaroli, Isabella Pisan, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Federica Mescia, Stefano Volpi, Marta Mosca, Angela Tincani, Angelo Ravelli, Corrado Murtas, Giovanni Candiano, Gianluca Caridi, Edoardo La Porta, Enrico Verrina
Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney...
March 27, 2024: Autoimmunity Reviews
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JOURNAL ARTICLE
Dominika Kanschik, Houtan Heidari, Kathrin Klein, Amin Polzin, Verena Veulemans, Jürgen Leick, Malte Kelm, Christian Jung, Tobias Zeus, Shazia Afzal
Due to the complex and variable anatomy of the left atrial appendage, percutaneous left atrial appendage closure (LAAC) can be challenging. In this study, we investigated the impact of fusion imaging (FI) on the LAAC learning curve of two interventionalists. The first interventionalist (IC 1) was initially trained without FI and continued his training with FI. The second interventionalist (IC 2) performed all procedures with FI. We compared the first 36 procedures without FI of IC 1 (group 1) with his next 36 interventions with FI (group 2)...
February 29, 2024: Journal of Cardiovascular Development and Disease
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JOURNAL ARTICLE
Zeus Jaren Nair, Iris Hanxing Gao, Aslam Firras, Kelvin Kian Long Chong, Eric D Hill, Pei Yi Choo, Cristina Colomer-Winter, Qingyan Chen, Caroline Manzano, Kevin Pethe, Kimberly A Kline
Daptomycin is a last-line antibiotic commonly used to treat vancomycin-resistant Enterococci, but resistance evolves rapidly and further restricts already limited treatment options. While genetic determinants associated with clinical daptomycin resistance (DAPR ) have been described, information on factors affecting the speed of DAPR acquisition is limited. The multiple peptide resistance factor (MprF), a phosphatidylglycerol-modifying enzyme involved in cationic antimicrobial resistance, is linked to DAPR in pathogens such as methicillin-resistant Staphylococcus aureus...
March 25, 2024: Molecular Microbiology
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REVIEW
Verena Veulemans, Oliver Maier, Tobias Zeus
Optimised implantation depth (OID) is crucial to obtain the best haemodynamic and clinical outcome during transcatheter heart valve (THV) deployment. OID ensures a better haemodynamic profile and is associated with a potential reduction in permanent pacemaker implantations, both of which are important during transcatheter aortic valve replacement (TAVR). Apart from patient-related anatomic conditions, many factors, such as THV and wire selection, as well as implantation strategies, can be controlled by the operator and facilitate the implantation process...
2024: Interventional Cardiology
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JOURNAL ARTICLE
Alice R Thomson, Hannah Hwa, Duanghathai Pasanta, Benjamin Hopwood, Helen J Powell, Ross Lawrence, Zeus G Tabuenca, Tomoki Arichi, Richard A E Edden, Xiaoqian Chai, Nicolaas A Puts
Human brain development is ongoing throughout childhood, with for example, myelination of nerve fibers and refinement of synaptic connections continuing until early adulthood. 1H-Magnetic Resonance Spectroscopy (1H-MRS) can be used to quantify the concentrations of endogenous metabolites (e.g. glutamate and γ -aminobutyric acid (GABA)) in the human brain in vivo and so can provide valuable, tractable insight into the biochemical processes that support postnatal neurodevelopment. This can feasibly provide new insight into and aid the management of neurodevelopmental disorders by providing chemical markers of atypical development...
March 1, 2024: Cerebral Cortex
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JOURNAL ARTICLE
Zeus Aranda, Viviana Caamal, Mariana Montaño, Daniel Bernal, Sergio Meneses
INTRODUCTION: Many Mexicans face barriers to receive delivery care from qualified professionals, especially indigenous and poor sectors of the population, which represent most of the population in the state of Chiapas. When access to institutional delivery care is an option, experiences with childbirth care are often poor. This underscores the need for evidence to improve the quality of services from the user's perspective. The present study was conceived with the objective of understanding how non-clinical aspects of care shape women's birthing experiences in public health institutions in Chiapas...
February 29, 2024: BMC Pregnancy and Childbirth
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JOURNAL ARTICLE
Sofia Marcolini, Jaime D Mondragón, Zeus T Dominguez-Vega, Peter P De Deyn, Natasha M Maurits
BACKGROUND: A lack of consensus exists in linking demographic, behavioral, and cognitive characteristics to biological stages of dementia, defined by the ATN (amyloid, tau, neurodegeneration) classification incorporating amyloid, tau, and neuronal injury biomarkers. METHODS: Using a random forest classifier we investigated whether 27 demographic, behavioral, and cognitive characteristics allowed distinction between ATN-defined groups with the same cognitive profile...
February 27, 2024: European Journal of Neurology
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REVIEW
Annemarie Smid, Zeus T Dominguez-Vega, Teus van Laar, D L Marinus Oterdoom, Anthony R Absalom, Martje E van Egmond, Gea Drost, J Marc C van Dijk
Tremor, bradykinesia, and rigidity are incapacitating motor symptoms that can be suppressed with stereotactic neurosurgical treatment like deep brain stimulation (DBS) and ablative surgery (e.g., thalamotomy, pallidotomy). Traditionally, clinicians rely on clinical rating scales for intraoperative evaluation of these motor symptoms during awake stereotactic neurosurgery. However, these clinical scales have a relatively high inter-rater variability and rely on experienced raters. Therefore, objective registration (e...
February 14, 2024: Neurosurgical Review
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JOURNAL ARTICLE
Stefano Benenati, Francesco Gallo, Won-Keun Kim, Arif A Khokhar, Tobias Zeus, Stefan Toggweiler, Roberto Galea, Federico De Marco, Antonio Mangieri, Damiano Regazzoli, Bernhard Reimers, Luis Nombela-Franco, Marco Barbanti, Ander Regueiro, Tommaso Piva, Josep Rodes-Cabau, Italo Porto, Antonio Colombo, Francesco Giannini, Alessandro Sticchi
BACKGROUND: Current European guidelines support transcatheter aortic valve implantation (TAVI) in intermediate-to-low-risk patients ≥75 years-old, but its prognostic relevance is unknown. METHODS: Intermediate-to-low-risk (The Society of Thoracic Surgeons score <8%) patients enrolled in the HORSE registry were included. We compared the populations aged under 75 with those over 75. The primary endpoint was all-cause mortality. RESULTS: A total of 2685 patients were included: 280 (8...
January 22, 2024: Journal of Cardiovascular Development and Disease
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JOURNAL ARTICLE
Zeus Harnod, Chen Lin, Hui-Wen Yang, Zih-Wen Wang, Han-Luen Huang, Tse-Yu Lin, Chun-Yao Huang, Lian-Yu Lin, Hsu-Wen V Young, Men-Tzung Lo
This paper proposes an innovative approach to generate a generalized myocardial ischemia database by modeling the virtual electrophysiology of the heart and the 12-lead electrocardiography projected by the in-silico model can serve as a ready-to-use database for automatic myocardial infarction/ischemia (MI) localization and classification. Although the virtual heart can be created by an established technique combining the cell model with personalized heart geometry to observe the spatial propagation of depolarization and repolarization waves, we developed a strategy based on the clinical pathophysiology of MI to generate a heterogeneous database with a generic heart while maintaining clinical relevance and reduced computational complexity...
January 14, 2024: Medical Image Analysis
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JOURNAL ARTICLE
Zeus Aranda, Sandra Vázquez, Anuraag Gopaluni, Laura Martínez, Mayra Ramírez, Ariwame Jiménez, Daniel Bernal, Ana L Rodríguez, Selene Chacón, Bruno Vargas, Isabel R Fulcher, Dale A Barnhart
BACKGROUND: Mexico is one of the countries with the greatest excess death due to COVID-19. Chiapas, the poorest state in the country, has been particularly affected. Faced with an exacerbated shortage of health professionals, medical supplies, and infrastructure to respond to the pandemic, the non-governmental organization Compañeros En Salud (CES) implemented a COVID-19 infection prevention and control program to limit the impact of the pandemic in the region. We evaluated CES's implementation of a community health worker (CHW)-led contact tracing intervention in eight rural communities in Chiapas...
January 18, 2024: BMC Health Services Research
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JOURNAL ARTICLE
Christine Quast, Raphael Phinicarides, Shazia Afzal, Verena Veulemans, Kathrin Klein, Nora Berisha, Pia Leuders, Ralf Erkens, Christian Jung, Florian Bönner, Malte Kelm, Amin Polzin, Tobias Zeus
OBJECTIVES: Dynamic Coronary Roadmap (DCR) is a software tool that creates a real-time dynamic coronary artery overlay on fluoroscopic images. The efficacy of DCR in significantly reducing contrast medium use during percutaneous coronary interventions (PCI) has previously been shown. In this study, we aimed to determine if DCR is equally effective irrespective of the performing investigator's experience level. METHODS: In this sub-analysis of a monocentric, open-label, randomized trial, 130 patients with hemodynamic relevant coronary type A and B lesions were randomized and contrast medium use was conducted with (+) or without (-) DCR software...
January 2024: Journal of Invasive Cardiology
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JOURNAL ARTICLE
Christophe Vandenbriele, René M'Pembele, Lisa Dannenberg, Daniel Metzen, Saif Zako, Carolin Helten, Philipp Mourikis, Denis Ignatov, Ragnar Huhn, Tim Balthazar, Tom Adriaenssens, Thomas Vanassche, Bart Meyns, Vasileios Panoulas, Maria Monteagudo-Vela, Deepa Arachchillage, Stefan Janssens, Clemens Scherer, Martin Orban, Tobias Petzold, Patrick Horn, Christian Jung, Tobias Zeus, Susanna Price, Ralf Westenfeld, Malte Kelm, Amin Polzin
BACKGROUND: Impella™ is increasingly used in cardiogenic shock. However, thromboembolic and bleeding events are frequent during percutaneous mechanical circulatory support (pMCS). OBJECTIVE: Therefore, we aimed to explore the optimal anticoagulation regime for pMCS to prevent thromboembolism and bleedings. METHODS: This hypothesis-generating multi-center cohort study investigated 170 patients with left-Impella™ support. We (A) compared bleeding/thrombotic events in two centers with therapeutic range (TR-aPTT) activated partial thromboplastin time (60-80s) and (B) compared events of these centers with one center with intermediate range aPTT (40-60s)...
March 15, 2024: International Journal of Cardiology
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JOURNAL ARTICLE
Sanusi Umar, Raveena Khanna, Alejandro Gonzalez, Kavish Chouhan, Juan Carlos Maldonado, Osman Tayfun Oguzoglu, Aron Nusbaum
BACKGROUND: Current no-shave long hair-follicular unit excision (LH-FUE) techniques employ recesses (slots, notches, or grooves) in punch tips to reduce the long-hair shaft break rate (SBR) and graft transection rate (GTR). However, these methods demand advanced skills and extended procedure time. OBJECTIVE: We aimed to evaluate a skin-responsive FUE technique without the use of recess-tipped punches, accommodating diverse hair and skin types in LH-FUE procedures...
2023: Clinical, Cosmetic and Investigational Dermatology
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JOURNAL ARTICLE
Brenda Nieto-Rivera, Zeus Saldaña-Ahuactzi, Israel Parra-Ortega, Alejandro Flores-Alanis, Ebzadrel Carbajal-Franco, Armando Cruz-Rangel, Stephania Galaviz-Hernández, Benjamín Romero-Navarro, Daniela de la Rosa-Zamboni, Marcela Salazar-García, Carmen A Contreras, Fernando Ortega-Riosvelasco, Irma López-Martínez, Gisela Barrera-Badillo, Hector Diaz-Garcia, Mariana Romo-Castillo, Sarbelio Moreno-Espinosa, Victor M Luna-Pineda
Acute respiratory infections (ARIs) are a major cause of morbidity and mortality among children. The causative pathogens show geographic and seasonal variations. We retrospectively evaluated the frequency and seasonality of respiratory pathogens in children and adolescents (age: 0-19 years) with ARIs treated between January 1, 2021, and March 31, 2022, at a single center in Mexico. Out of 2400 patients, 1,603 were diagnosed with SARS-CoV-2 infection and 797 were diagnosed with other common respiratory pathogens (CRPs)...
November 13, 2023: Scientific Reports
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JOURNAL ARTICLE
Zeus T Dominguez-Vega, Mariano Bernaldo de Quiros, Jan Willem J Elting, Deborah A Sival, Natasha M Maurits
Early onset ataxia (EOA) and developmental coordination disorder (DCD) both affect cerebellar functioning in children, making the clinical distinction challenging. We here aim to derive meaningful features from quantitative SARA-gait data (i.e., the gait test of the scale for the assessment and rating of ataxia (SARA)) to classify EOA and DCD patients and typically developing (CTRL) children with better explainability than previous classification approaches. We collected data from 18 EOA, 14 DCD and 29 CTRL children, while executing both SARA gait tests...
October 12, 2023: Sensors
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