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https://www.readbyqxmd.com/read/28178850/the-threshold-distance-associated-with-walking-from-home-to-school
#1
Carlos Rodríguez-López, Zeus M Salas-Fariña, Emilio Villa-González, Milkana Borges-Cosic, Manuel Herrador-Colmenero, Jesús Medina-Casaubón, Francisco B Ortega, Palma Chillón
Active commuting to school has health implications among young people. We aimed to (a) examine the patterns of commuting to school in children and adolescents regarding gender and area of residence, (b) study the association between distance from home to school and mode of commuting, and (c) identify the threshold distance below which young people are more likely to walk to school. A total of 6,004 students aged 7 to 18 years from Spain participated in this study. Mode of commuting was self-reported and distance was objectively measured using Google Maps software...
February 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28115921/corrigendum-effects-of-lng-mutations-on-lnga-expression-processing-and-cs21-assembly-in-enterotoxigenic-escherichia-coli-e9034a
#2
Zeus Saldaña-Ahuactzi, Gerardo E Rodea, Ariadnna Cruz-Córdova, Viridiana Rodríguez-Ramírez, Karina Espinosa-Mazariego, Martín A González-Montalvo, Sara A Ochoa, Bertha González-Pedrajo, Carlos A Eslava-Campos, Edgar O López-Villegas, Rigoberto Hernández-Castro, José Arellano-Galindo, Genaro Patiño-López, Juan Xicohtencatl-Cortes
[This corrects the article on p. 1201 in vol. 7, PMID: 27536289.].
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28112459/deep-sedation-vs-general-anesthesia-in-232-patients-undergoing-percutaneous-mitral-valve-repair-using-the-mitraclip-%C3%A2-system
#3
Patrick Horn, Katharina Hellhammer, Michael Minier, Monika A Stenzel, Verena Veulemans, Tienush Rassaf, Peter Luedike, Julia Pohl, Jan Balzer, Tobias Zeus, Malte Kelm, Ralf Westenfeld
OBJECTIVES: To investigate in a series of 232 patients whether the MitraClip(®) procedure can be performed safely using deep sedation (DS) without general anesthesia (GA). BACKGROUND: Transcatheter mitral valve repair using the MitraClip(®) system is a safe and effective therapy for severe mitral regurgitation (MR) in patients who are at high operative risk or are unsuitable for surgery. For these patients, avoidance of GA might be beneficial. METHODS: Between 2011 and 2015, we performed 232 MitraClip(®) procedures for the treatment of severe MR...
January 23, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28103806/the-effect-of-fresh-gas-flow-rate-and-type-of-anesthesia-machine-on-time-to-reach-target-sevoflurane-concentration
#4
Hye Won Shin, Hae Na Yu, Go Eun Bae, Hyub Huh, Ji Yong Park, Ji Young Kim
BACKGROUND: Anesthesia machines have been developed by the application of new technology for rapid and easier control of anesthetic concentration. In this study, we used a test lung to investigate whether the time taken to reach the target sevoflurane concentration varies with the rate of fresh gas flow (FGF) and type of anesthesia machine (AM). METHODS: We measured the times taken to reach the target sevoflurane concentration (2 minimum alveolar concentration = 4%) at variable rates of FGF (0...
January 19, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28089147/sequent-please-vs-pantera-lux-drug-coated-balloon-angioplasty-in-real-life-results-from-the-d%C3%A3-sseldorf-dcb-registry
#5
Athena Assadi-Schmidt, Annemarie Mohring, Eva Liebsch, Lisa Dannenberg, Alina Achilles, Martin Pöhl, Shazia Afzal, Verena Veulemans, Patrick Horn, Roberto Sansone, Florian Bönner, Bodo Levkau, Malte Kelm, Tobias Zeus, Amin Polzin
BACKGROUND: In-stent restenosis (ISR) is still a major concern in interventional cardiology. Drug coated balloon (DCB) angioplasty has been shown to be a promising option in treatment of ISR. However heterogeneity of different DCBs in suppression of neointimal growth has been described in a porcine model of coronary ISR. Therefore, in this registry analysis, we compared two frequently used paclitaxel eluting DCBs, the SeQuent Please and the Pantera Lux DCB. METHODS: 571 patients were treated with DCB angioplasty at the Heinrich-Heine University Düsseldorf between 2009 and 2012...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28056776/evidence-for-genetic-variation-in-natterer-s-bats-myotis-nattereri-across-three-regions-in-germany-but-no-evidence-for-co-variation-with-their-associated-astroviruses
#6
Tanja K Halczok, Kerstin Fischer, Robert Gierke, Veronika Zeus, Frauke Meier, Christoph Treß, Anne Balkema-Buschmann, Sébastien J Puechmaille, Gerald Kerth
BACKGROUND: As bats have recently been described to harbor many different viruses, several studies have investigated the genetic co-variation between viruses and different bat species. However, little is known about the genetic co-variation of viruses and different populations of the same bat species, although such information is needed for an understanding of virus transmission dynamics within a given host species. We hypothesized that if virus transmission between host populations depends on events linked to gene flow in the bats, genetic co-variation should exist between host populations and astroviruses...
January 5, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28009957/implantation-of-a-sapien-3-valve-in-a-patient-with-pure-aortic-regurgitation
#7
Jan-Philipp Minol, Verena Veulemans, Tobias Zeus, Alexander Blehm
Transcatheter aortic valve implantation (TAVI) is an emerging treatment for high-risk patients with aortic stenosis. Aortic regurgitation is considered to be a relative contraindication for transcatheter procedures, as a non-calcified aortic annulus poses the risk of an insufficient anchoring of the transcatheter aortic valve prosthesis. Herein is described the case of a patient who suffered from recurrent aortic valve regurgitation after valve-sparing repair, and which was successfully treated by the transcatheter implantation of an Edwards SAPIEN 3™ prosthesis...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27995471/percutaneous-closure-of-a%C3%A2-left-atrial-appendage-with-relevant-suture-dehiscence
#8
L Kleinebrecht, V Veulemans, A Polzin, M Kelm, T Zeus
Atrial fibrillation is a widespread disease and highly relevant as it carries an extended risk for ischaemic stroke. Surgical closure of the left atrial appendage is routinely performed during open heart surgery in patients with atrial fibrillation with the aim of thromboembolic protection. In this report we present a successful percutaneous closure of a left atrial appendage, which showed clinically relevant suture dehiscence several years after surgical closure.
February 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27992120/dabigatran-enhances-platelet-reactivity-and-platelet-thrombin-receptor-expression-in-patients-with-atrial-fibrillation
#9
A Achilles, A Mohring, L Dannenberg, M Grandoch, T Hohlfeld, J W Fischer, B Levkau, M Kelm, T Zeus, A Polzin
: Essentials Whether or not dabigatran enhances the risk of myocardial infarction is under discussion. We measured platelet reactivity and thrombin receptor expression in dabigatran patients. Platelet reactivity and thrombin receptor expression is enhanced during dabigatran treatment. This should be considered when choosing the optimal direct oral anticoagulant for individuals. SUMMARY: Background The direct oral anticoagulant (DOAC) dabigatran is a direct thrombin inhibitor...
December 19, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27989041/left-atrial-and-left-ventricular-function-and-remodeling-following-percutaneous-mitral-valve-repair
#10
Christos Rammos, Tobias Zeus, Jan Balzer, Verena Veulemans, Katharina Hellhammer, Svenja Niebel, Malte Kelm, Tienush Rassaf
BACKGROUND: Mitral regurgitation causes left atrial (LA) and left ventricular (LV) dysfunction, dilatation, and remodeling. Following percutaneous mitral valve repair (PMVR) using the MitraClip® approach, reverse cardiac remodeling is desirable. To date, the influence of PMVR on LA and segmental LV function and remodeling has not been investigated in detail. METHODS: Twenty-six patients who received the MitraClip device were enrolled in an open-label, single-center observational study...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27970046/tct-669-valve-in-valve-in-small-surgical-valves-predictors-for-survival-and-elevated-post-procedural-gradients-insights-from-the-valve-in-valve-international-data-vivid-registry
#11
Matheus Simonato Dos Santos, Mohamed Abdel-Wahab, David Hildick-Smith, John Webb, Yaron Arbel, Hafid Amrane, Brian Whisenant, Matthew Miller, Marco Agrifoglio, Stefano Salizzoni, Patrizia Presbitero, Christian Frerker, Vasco Gama Ribeiro, Helene Eltchaninoff, Arend de Weger, Alfredo Cerillo, Ariel Finkelstein, Luca Testa, Tobias Zeus, Claudia Fiorina, Piotr Chodor, Dan Ioanes, Neil Moat, Danny Dvir
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27966185/safety-and-efficacy-of-transseptal-puncture-guided-by-real-time-fusion-of-echocardiography-and-fluoroscopy
#12
S Afzal, V Veulemans, J Balzer, T Rassaf, K Hellhammer, A Polzin, M Kelm, T Zeus
AIMS: Visual guidance through echocardiography and fluoroscopy is crucial for a successful transseptal puncture (TSP) in a prespecified region of the fossa ovalis. The novel EchoNavigator system Release II (EchoNav II, Philips Healthcare, Andover, Massachusetts, USA) enables the real-time fusion of fluoroscopic and echocardiographic images. We evaluated this new imaging method in respect to safety and efficacy of TSP during MitraClip implantation and left atrial appendage closure...
February 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27847562/optimal-c-arm-angulation-during-transcatheter-aortic-valve-replacement-accuracy-of-a-rotational-c-arm-computed-tomography-based-three-dimensional-heart-model
#13
Verena Veulemans, Sabine Mollus, Axel Saalbach, Max Pietsch, Katharina Hellhammer, Tobias Zeus, Ralf Westenfeld, Jürgen Weese, Malte Kelm, Jan Balzer
AIM: To investigate the accuracy of a rotational C-arm CT-based 3D heart model to predict an optimal C-arm configuration during transcatheter aortic valve replacement (TAVR). METHODS: Rotational C-arm CT (RCT) under rapid ventricular pacing was performed in 57 consecutive patients with severe aortic stenosis as part of the pre-procedural cardiac catheterization. With prototype software each RCT data set was segmented using a 3D heart model. From that the line of perpendicularity curve was obtained that generates a perpendicular view of the aortic annulus according to the right-cusp rule...
October 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27843814/dimeric-and-trimeric-fusion-proteins-generated-with-fimbrial-adhesins-of-uropathogenic-escherichia-coli
#14
Víctor M Luna-Pineda, Juan Pablo Reyes-Grajeda, Ariadnna Cruz-Córdova, Zeus Saldaña-Ahuactzi, Sara A Ochoa, Carmen Maldonado-Bernal, Vicenta Cázares-Domínguez, Leticia Moreno-Fierros, José Arellano-Galindo, Rigoberto Hernández-Castro, Juan Xicohtencatl-Cortes
Urinary tract infections (UTIs) are associated with high rates of morbidity and mortality worldwide, and uropathogenic Escherichia coli (UPEC) is the main etiologic agent. Fimbriae assembled on the bacterial surface are essential for adhesion to the urinary tract epithelium. In this study, the FimH, CsgA, and PapG adhesins were fused to generate biomolecules for use as potential target vaccines against UTIs. The fusion protein design was generated using bioinformatics tools, and template fusion gene sequences were synthesized by GenScript in the following order fimH-csgA-papG-fimH-csgA (fcpfc) linked to the nucleotide sequence encoding the [EAAAK]5 peptide...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27721240/targeting-cag-repeat-rnas-reduces-huntington-s-disease-phenotype-independently-of-huntingtin-levels
#15
Laura Rué, Mónica Bañez-Coronel, Jordi Creus-Muncunill, Albert Giralt, Rafael Alcalá-Vida, Gartze Mentxaka, Birgit Kagerbauer, M Teresa Zomeño-Abellán, Zeus Aranda, Veronica Venturi, Esther Pérez-Navarro, Xavier Estivill, Eulàlia Martí
Huntington's disease (HD) is a polyglutamine disorder caused by a CAG expansion in the Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal function is traditionally associated with HD pathogenesis; however, recent evidence has also linked HD pathogenesis to RNA stable hairpins formed by the mutant HTT expansion. Here, we have shown that a locked nucleic acid-modified antisense oligonucleotide complementary to the CAG repeat (LNA-CTG) preferentially binds to mutant HTT without affecting HTT mRNA or protein levels...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27696842/chiroptical-asymmetric-reaction-screening-via-multicomponent-self-assembly
#16
Zeus A De Los Santos, Christian Wolf
The self-assembly of a stereodynamic phosphine ligand, Pd(II) and a chiral amine, amino alcohol or amino acid gen-erates characteristic UV and CD signals that can be used for quantitative stereochemical analysis of the bound substrate. A robust mix-and-measure chiroptical sensing protocol has been developed and used for the determination of the abso-lute configuration, ee and yield of an amine produced by iridium catalyzed asymmetric hydrogenation of an iminium salt. The analysis requires only 1 mg of the crude reaction mixture and minimizes cost, labor, time and waste...
October 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27536289/effects-of-lng-mutations-on-lnga-expression-processing-and-cs21-assembly-in-enterotoxigenic-escherichia-coli-e9034a
#17
Zeus Saldaña-Ahuactzi, Gerardo E Rodea, Ariadnna Cruz-Córdova, Viridiana Rodríguez-Ramírez, Karina Espinosa-Mazariego, Martín A González-Montalvo, Sara A Ochoa, Bertha González-Pedrajo, Carlos A Eslava-Campos, Edgar O López-Villegas, Rigoberto Hernández-Castro, José Arellano-Galindo, Genaro Patiño-López, Juan Xicohtencatl-Cortes
Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity in children under 5 years of age in low- and middle-income countries and a leading cause of traveler's diarrhea worldwide. The ability of ETEC to colonize the intestinal epithelium is mediated by fimbrial adhesins, such as CS21 (Longus). This adhesin is a type IVb pilus involved in adherence to intestinal cells in vitro and bacterial self-aggregation. Fourteen open reading frames have been proposed to be involved in CS21 assembly, hitherto only the lngA and lngB genes, coding for the major (LngA) and minor (LngB) structural subunit, have been characterized...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27301652/dipyrone-comedication-in-aspirin-treated-stroke-patients-impairs-outcome
#18
Lisa Dannenberg, Vladimir Erschoff, Florian Bönner, Michael Gliem, Sebastian Jander, Bodo Levkau, Malte Kelm, Thomas Hohlfeld, Tobias Zeus, Amin Polzin
BACKGROUND: >50% of stroke patients rely on analgesic medication to control pain. Aspirin is the mainstay of medical treatment of stroke patients; however analgesic medication with dipyrone impairs aspirin antiplatelet effects ex-vivo. The clinical impact of this impairment is unknown. Therefore, we aimed to determine aspirin antiplatelet effects and neurological outcome in stroke patients with aspirin and dipyrone comedication. METHODS: We conducted a prospective cohort study in 41 patients with stroke...
December 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27100214/on-the-road-first-in-man-bifurcation-percutaneous-coronary-intervention-with-the-use-of-a-dynamic-coronary-road-map-and-stentboost-live-imaging-system
#19
Lisa Dannenberg, Amin Polzin, Roland Bullens, Malte Kelm, Tobias Zeus
No abstract text is available yet for this article.
July 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27073910/comparison-of-manual-and-automated-preprocedural-segmentation-tools-to-predict-the-annulus-plane-angulation-and-c-arm-positioning-for-transcatheter-aortic-valve-replacement
#20
COMPARATIVE STUDY
Verena Veulemans, Tobias Zeus, Laura Kleinebrecht, Jan Balzer, Katharina Hellhammer, Amin Polzin, Patrick Horn, Alexander Blehm, Jan-Philipp Minol, Patric Kröpil, Ralf Westenfeld, Tienush Rassaf, Artur Lichtenberg, Malte Kelm
BACKGROUND: Preprocedural manual multi-slice-CT-segmentation tools (MSCT-ST) define the gold standard for planning transcatheter aortic valve replacement (TAVR). They are able to predict the perpendicular line of the aortic annulus (PPL) and to indicate the corresponding C-arm angulation (CAA). Fully automated planning-tools and their clinical relevance have not been systematically evaluated in a real world setting so far. METHODS AND RESULTS: The study population consists of an all-comers cohort of 160 consecutive TAVR patients with a drop out of 35 patients for technical and anatomical reasons...
2016: PloS One
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