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https://www.readbyqxmd.com/read/28614821/thromboxane-formation-assay-to-identify-high-on-treatment-platelet-reactivity-to-aspirin
#1
Annemarie Mohring, Kerstin Piayda, Lisa Dannenberg, Saif Zako, Theresa Schneider, Kirsten Bartkowski, Bodo Levkau, Tobias Zeus, Malte Kelm, Thomas Hohlfeld, Amin Polzin
Platelet inhibition by aspirin is indispensable in the secondary prevention of cardiovascular events. Nevertheless, impaired aspirin antiplatelet effects (high on-treatment platelet reactivity [HTPR]) are frequent. This is associated with an enhanced risk of cardiovascular events. The current gold standard to evaluate platelet hyper-reactivity despite aspirin intake is the light-transmittance aggregometry (LTA). However, pharmacologically, the most specific test is the measurement of arachidonic acid (AA)-induced thromboxane (TX) B2 formation...
June 15, 2017: Pharmacology
https://www.readbyqxmd.com/read/28574445/cu-nanoparticles-in-hydrogels-of-chitosan-pva-affects-the-characteristics-of-post-harvest-and-bioactive-compounds-of-jalape%C3%A3-o-pepper
#2
Zeus H Pinedo-Guerrero, Alma Delia Hernández-Fuentes, Hortensia Ortega-Ortiz, Adalberto Benavides-Mendoza, Gregorio Cadenas-Pliego, And Antonio Juárez-Maldonado
Peppers are consumed all over the world due to the flavor, aroma, and color that they add to food. Additionally, they play a role in human health, as they contain a high concentration of bioactive compounds and antioxidants. The treatments used were an absolute control, Cs-PVA, and four treatments with 0.02, 0.2, 2, and 10 mg (nCu) g(-1) (Cs-PVA). The application of Cu nanoparticles in chitosan-PVA hydrogels increases the content of capsaicin by up to 51% compared to the control. This application also increases the content of antioxidants ABTS [2,2'-azino-bis (3-ethylbenzothiazolin-6-sulfonic acid)] and DPPH (2,2-diphenyl-1-picrylhydrazyl), total phenols and flavonoids (4%, 6...
June 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28560186/tracking-bioluminescent-etec-during-in-vivo-balb-c-mouse-colonization
#3
Gerardo E Rodea, Francisco X Montiel-Infante, Ariadnna Cruz-Córdova, Zeus Saldaña-Ahuactzi, Sara A Ochoa, Karina Espinosa-Mazariego, Rigoberto Hernández-Castro, Juan Xicohtencatl-Cortes
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea worldwide. Adhesion to the human intestinal tract is crucial for colonization. ETEC adhesive structures have been extensively studied; however, colonization dynamics remain uncharacterized. The aim of this study was to track bioluminescent ETEC during in vivo infection. The promoter region of dnaK was fused with the luc gene, resulting in the pRMkluc vector. E. coli K-12 and ETEC FMU073332 strains were electroporated with pRMkluc. E. coli K-12 pRMkluc was bioluminescent; in contrast, the E...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28516510/proteomic-analysis-of-lupinus-angustifolius-var-zeus-and-bojar-and-lupinus-luteus-var-lord-and-parys-seed-proteins-and-their-hydrolysates
#4
Jaroslaw Czubinski, Magdalena Montowska, Edward Pospiech, Eleonora Lampart-Szczapa
BACKGROUND: Proteins enzymatic digestion is a very complex process, during which some components are degraded, while others remain in an unchanged form. Moreover, the enzymatic hydrolysis is one of the most popular methods used to reduce the allergenicity of food proteins. In this study, the efficiency of enzymatic hydrolysis of lupin seeds proteins was assessed by proteomic analysis performed by two-dimensional gel electrophoresis (2-DE) coupled with mass spectrometry identification...
May 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28469901/use-of-electronic-clinical-decision-support-and-hard-stops-to-decrease-unnecessary-thyroid-function-testing
#5
Sonia Dalal, Siddharth Bhesania, Steven Silber, Parag Mehta
NewYork-Presbyterian Brooklyn Methodist Hospital embarked on a Zero Unnecessary Study (ZEUS) initiative, whereby all aspects of clinical care were evaluated and strategies were implemented to mitigate waste. An opportunity was found in regards to thyroid function testing. It has been shown that certain TFTs are ordered far more often than clinically indicated. Free T3 (fT3) and Free T4 (fT4) are only indicated when the TSH is abnormal in the inpatient setting, with rare exceptions. Thus, a clinical algorithm for Clinical Decision Support (CDS) and Hard Stops (HS) were incorporated into the Electronic Medical Record (EMR) to prevent fT3 or fT4 to be ordered without an abnormal TSH, with certain predefined exceptions...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28445598/dabigatran-enhances-platelet-reactivity-and-platelet-thrombin-receptor-expression-in-patients-with-atrial-fibrillation-reply
#6
Alina Achilles, Annemarie Mohring, Tobias Zeus, Malte Kelm, Amin Polzin
Firstly, we would like to thank Bonello et al. for their comment on our recent publication. We completely agree that until now, data were contradicting regarding the impact of dabigatran on platelet reactivity. Additionally, we completely agree that during the last year, different groups have clearly shown enhanced platelet aggregation and platelet adhesion in dabigatran treated patients. [1-3] Furthermore, two different mechanisms have been described (enhanced platelet adhesion to the endothelium mediated by GPIb-α by Petzold et al...
April 26, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28423018/comprehensive-analysis-of-phospholipids-and-glycolipids-in-the-opportunistic-pathogen-enterococcus-faecalis
#7
Rafi Rashid, Amaury Cazenave-Gassiot, Iris H Gao, Zeus J Nair, Jaspal K Kumar, Liang Gao, Kimberly A Kline, Markus R Wenk
Enterococcus faecalis is a Gram-positive, opportunistic, pathogenic bacterium that causes a significant number of antibiotic-resistant infections in hospitalized patients. The development of antibiotic resistance in hospital-associated pathogens is a formidable public health threat. In E. faecalis and other Gram-positive pathogens, correlations exist between lipid composition and antibiotic resistance. Resistance to the last-resort antibiotic daptomycin is accompanied by a decrease in phosphatidylglycerol (PG) levels, whereas multiple peptide resistance factor (MprF) converts anionic PG into cationic lysyl-PG via a trans-esterification reaction, providing resistance to cationic antimicrobial peptides...
2017: PloS One
https://www.readbyqxmd.com/read/28414709/robotic-surgery-fast-forward-to-telemedicine
#8
George B Stefano
Since the realization that certain maladies can be corrected via surgical techniques, we have been consumed by the desire to constantly advance the tools of surgery, as well as the techniques. In recent times, computer-assisted surgical tools have emerged and are growing in their use. The Puma 560 emerged in 1985 for brain biopsies and laparoscopic surgery. Prostatic surgery was performed by the Probot in 1988. In 1992, fittings in the femur were placed using the ROBODOC. These early robotic endeavors gave rise to AESOP, ZEUS and the relatively intuitive da Vinci® Surgical System...
April 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28407903/perceived-bitterness-character-of-beer-in-relation-to-hop-variety-and-the-impact-of-hop-aroma
#9
Olayide Oladokun, Sue James, Trevor Cowley, Frieda Dehrmann, Katherine Smart, Joanne Hort, David Cook
The impact of hop variety and hop aroma on perceived beer bitterness intensity and character was investigated using analytical and sensory methods. Beers made from malt extract were hopped with 3 distinctive hop varieties (Hersbrucker, East Kent Goldings, Zeus) to achieve equi-bitter levels. A trained sensory panel determined the bitterness character profile of each singly-hopped beer using a novel lexicon. Results showed different bitterness character profiles for each beer, with hop aroma also found to change the hop variety-derived bitterness character profiles of the beer...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28388746/-update-on-left-atrial-appendage-closure-2017
#10
Volker Schulze, Tobias Zeus, Horst Sievert
No abstract text is available yet for this article.
April 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28329129/first-experience-with-real-time-3d-anatomical-fusion-imaging-during-left-atrial-appendage-occluder-implantation
#11
Shazia Afzal, Dagmar Soetemann, Niels Nijhof, Malte Kelm, Tobias Zeus
No abstract text is available yet for this article.
June 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28285917/examining-the-structure-activity-relationship-of-benzopyran-based-inhibitors-of-the-hypoxia-inducible-factor-1-pathway
#12
Jalisa Ferguson, Zeus De Los Santos, Narra Devi, Erwin Van Meir, Sarah Zingales, Binghe Wang
Many forms of solid tumor have a characteristic feature known as hypoxia, which describes a low or non-existent presence of oxygen in the cellular microenvironment. This decrease in oxygen causes activation of the hypoxia inducible factor (HIF) pathway, which activates the transcription of many genes that cause cell proliferation, metastasis, increased glycolysis and angiogenesis. Increased HIF expression has been linked with poor patient prognosis, increased malignancy, and therapeutic resistance. Previous work in our lab has identified 1 and 2 as inhibitors of the HIF pathway, specifically as disrupters of the p300-HIF-1α complex formation...
April 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28262342/analgesic-medication-with-dipyrone-in-patients-with-coronary-artery-disease-relation-to-macce
#13
Alina Achilles, Annemarie Mohring, Lisa Dannenberg, Kerstin Piayda, Bodo Levkau, Thomas Hohlfeld, Tobias Zeus, Malte Kelm, Amin Polzin
BACKGROUND: The non-opioid analgesic dipyrone can trigger life-threatening blood formation disorders. However, it is frequently used, as many patients with coronary artery disease (CAD) rely on non-opioid analgesics to relieve pain. In this study, we investigated the incidence of death, myocardial infarction (MI) or stroke in CAD patients with aspirin and dipyrone comedication as compared to aspirin-alone. METHODS: We conducted an observational pilot study in 72 CAD patients with aspirin ± dipyrone comedication in the department of cardiology of the University Hospital Düsseldorf...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28260186/efficacy-of-zofenopril-vs-irbesartan-in-combination-with-a-thiazide-diuretic-in-hypertensive-patients-with-multiple-risk-factors-not-controlled-by-a-previous-monotherapy-a-review-of-the-double-blind-randomized-z-studies
#14
REVIEW
Stefano Omboni, Ettore Malacco, Claudio Napoli, Pietro Amedeo Modesti, Athanasios Manolis, Gianfranco Parati, Enrico Agabiti-Rosei, Claudio Borghi
Combinations between an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB) and hydrochlorothiazide (HCTZ) are among the recommended treatments for hypertensive patients uncontrolled by monotherapy. Four randomized, double-blind, parallel group studies with a similar design, including 1469 hypertensive patients uncontrolled by a previous monotherapy and with ≥1 cardiovascular risk factor, compared the efficacy of a combination of a sulfhydryl ACE inhibitor (zofenopril at 30 or 60 mg) or an ARB (irbesartan at 150 or 300 mg) plus HCTZ 12...
April 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28178850/the-threshold-distance-associated-with-walking-from-home-to-school
#15
Carlos Rodríguez-López, Zeus M Salas-Fariña, Emilio Villa-González, Milkana Borges-Cosic, Manuel Herrador-Colmenero, Jesús Medina-Casaubón, Francisco B Ortega, Palma Chillón
Active commuting to school has health implications among young people. We aimed to (a) examine the patterns of commuting to school in children and adolescents regarding gender and area of residence, (b) study the association between distance from home to school and mode of commuting, and (c) identify the threshold distance below which young people are more likely to walk to school. A total of 6,004 students aged 7 to 18 years from Spain participated in this study. Mode of commuting was self-reported and distance was objectively measured using Google Maps software...
February 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28115921/corrigendum-effects-of-lng-mutations-on-lnga-expression-processing-and-cs21-assembly-in-enterotoxigenic-escherichia-coli-e9034a
#16
Zeus Saldaña-Ahuactzi, Gerardo E Rodea, Ariadnna Cruz-Córdova, Viridiana Rodríguez-Ramírez, Karina Espinosa-Mazariego, Martín A González-Montalvo, Sara A Ochoa, Bertha González-Pedrajo, Carlos A Eslava-Campos, Edgar O López-Villegas, Rigoberto Hernández-Castro, José Arellano-Galindo, Genaro Patiño-López, Juan Xicohtencatl-Cortes
[This corrects the article on p. 1201 in vol. 7, PMID: 27536289.].
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28112459/deep-sedation-vs-general-anesthesia-in-232-patients-undergoing-percutaneous-mitral-valve-repair-using-the-mitraclip-%C3%A2-system
#17
Patrick Horn, Katharina Hellhammer, Michael Minier, Monika A Stenzel, Verena Veulemans, Tienush Rassaf, Peter Luedike, Julia Pohl, Jan Balzer, Tobias Zeus, Malte Kelm, Ralf Westenfeld
OBJECTIVES: To investigate in a series of 232 patients whether the MitraClip(®) procedure can be performed safely using deep sedation (DS) without general anesthesia (GA). BACKGROUND: Transcatheter mitral valve repair using the MitraClip(®) system is a safe and effective therapy for severe mitral regurgitation (MR) in patients who are at high operative risk or are unsuitable for surgery. For these patients, avoidance of GA might be beneficial. METHODS: Between 2011 and 2015, we performed 232 MitraClip(®) procedures for the treatment of severe MR...
January 23, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28103806/the-effect-of-fresh-gas-flow-rate-and-type-of-anesthesia-machine-on-time-to-reach-target-sevoflurane-concentration
#18
Hye Won Shin, Hae Na Yu, Go Eun Bae, Hyub Huh, Ji Yong Park, Ji Young Kim
BACKGROUND: Anesthesia machines have been developed by the application of new technology for rapid and easier control of anesthetic concentration. In this study, we used a test lung to investigate whether the time taken to reach the target sevoflurane concentration varies with the rate of fresh gas flow (FGF) and type of anesthesia machine (AM). METHODS: We measured the times taken to reach the target sevoflurane concentration (2 minimum alveolar concentration = 4%) at variable rates of FGF (0...
January 19, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28089147/sequent-please-vs-pantera-lux-drug-coated-balloon-angioplasty-in-real-life-results-from-the-d%C3%A3-sseldorf-dcb-registry
#19
Athena Assadi-Schmidt, Annemarie Mohring, Eva Liebsch, Lisa Dannenberg, Alina Achilles, Martin Pöhl, Shazia Afzal, Verena Veulemans, Patrick Horn, Roberto Sansone, Florian Bönner, Bodo Levkau, Malte Kelm, Tobias Zeus, Amin Polzin
BACKGROUND: In-stent restenosis (ISR) is still a major concern in interventional cardiology. Drug coated balloon (DCB) angioplasty has been shown to be a promising option in treatment of ISR. However heterogeneity of different DCBs in suppression of neointimal growth has been described in a porcine model of coronary ISR. Therefore, in this registry analysis, we compared two frequently used paclitaxel eluting DCBs, the SeQuent Please and the Pantera Lux DCB. METHODS: 571 patients were treated with DCB angioplasty at the Heinrich-Heine University Düsseldorf between 2009 and 2012...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28056776/evidence-for-genetic-variation-in-natterer-s-bats-myotis-nattereri-across-three-regions-in-germany-but-no-evidence-for-co-variation-with-their-associated-astroviruses
#20
Tanja K Halczok, Kerstin Fischer, Robert Gierke, Veronika Zeus, Frauke Meier, Christoph Treß, Anne Balkema-Buschmann, Sébastien J Puechmaille, Gerald Kerth
BACKGROUND: As bats have recently been described to harbor many different viruses, several studies have investigated the genetic co-variation between viruses and different bat species. However, little is known about the genetic co-variation of viruses and different populations of the same bat species, although such information is needed for an understanding of virus transmission dynamics within a given host species. We hypothesized that if virus transmission between host populations depends on events linked to gene flow in the bats, genetic co-variation should exist between host populations and astroviruses...
January 5, 2017: BMC Evolutionary Biology
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