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https://www.readbyqxmd.com/read/29177020/epigenetic-regulation-of-axl-and-risk-of-childhood-asthma-symptoms
#1
Lu Gao, Joshua Millstein, Kimberly D Siegmund, Louis Dubeau, Rachel Maguire, Frank D Gilliland, Susan K Murphy, Cathrine Hoyo, Carrie V Breton
Background: AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may affect numerous immune-related health conditions. However, the role for AXL in asthma, including its epigenetic regulation, has not been extensively studied. Methods: We investigated the association between AXL DNA methylation at birth and risk of childhood asthma symptoms at age 6 years. DNA methylation of multiple CpG loci across the regulatory regions of AXL was measured in newborn bloodspots using the Illumina HumanMethylation450 array on a subset of 246 children from the Children's Health Study (CHS)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29167298/prevalence-and-burden-of-chronic-bronchitis-symptoms-results-from-the-bold-study
#2
Filip Mejza, Louisa Gnatiuc, A Sonia Buist, William M Vollmer, Bernd Lamprecht, Daniel O Obaseki, Pawel Nastalek, Ewa Nizankowska-Mogilnicka, Peter G J Burney
We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study.Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years.Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29166367/smoke-free-policies-in-the-world-s-50-busiest-airports-august-2017
#3
Michael A Tynan, Elizabeth Reimels, Jennifer Tucker, Brian A King
Exposure to secondhand smoke from burning tobacco products causes premature death and disease, including coronary heart disease, stroke, and lung cancer among nonsmoking adults and sudden infant death syndrome, acute respiratory infections, middle ear disease, exacerbated asthma, respiratory symptoms, and decreased lung function in children (1,2). The U.S. Surgeon General has concluded that there is no risk-free level of exposure to secondhand smoke (1). Previous CDC reports on airport smoke-free policies found that most large-hub airports in the United States prohibit smoking (3); however, the extent of smoke-free policies at airports globally has not been assessed...
November 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29161804/importance-of-biological-ultrafine-particles-in-indoor-dust-as-a-pathogenesis-of-chronic-inflammatory-lung-diseases
#4
Young-Koo Jee, Jinho Yang, Yoon-Keun Kim, You-Young Kim, Tae Soo Kang
The role of infectious agents in the etiology of inflammatory diseases once believed to be non-infectious is increasingly being recognized. Many bacterial components in the indoor dust can evoke inflammatory lung diseases. Bacteria secrete nanometer-sized vesicles into the extracellular milieu, so-called extracellular vesicles (EVs). which are pathophysiologically related to inflammatory diseases. Microbiota compositions in the indoor dust revealed the presence of both gram-negative and gram-positive bacteria...
November 17, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29129163/occupational-lung-diseases-in-australia
#5
Ryan F Hoy, Fraser Brims
Occupational exposures are an important determinant of respiratory health. International estimates note that about 15% of adult-onset asthma, 15% of chronic obstructive pulmonary disease and 10-30% of lung cancer may be attributable to hazardous occupational exposures. One-quarter of working asthmatics either have had their asthma caused by work or adversely affected by workplace conditions. Recently, cases of historical occupational lung diseases have been noted to occur with new exposures, such as cases of silicosis in workers fabricating kitchen benchtops from artificial stone products...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29127758/-physical-activity-the-holy-grail-of-modern-medicine
#6
Vladimír Tuka, Martina Daňková, Karel Riegel, Martin Matoulek
Movement is the basic attribute of life. It is not surprising that the return to regular physical activity is a very effective and cheap means of preventing and treating most non-cummunicable diseases. Therefore, every physician should be able to prescribe a suitable physical activity. The minimum amount of physical activity with proven effects in primary prevention of chronic diseases is relatively low: 150 minutes of moderate physical activity or 75 minutes of high intensity exercise per week or a combination of the two...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29083017/pulmonary-prevention-program-in-the-proszowice-county-description-and-results
#7
Wojciech Skucha, Filip Mejza, Pawel Nastalek, Zbigniew Doniec
INTRODUCTION: In the Proszowice county, both lung cancer and chronic obstructive pulmonary disease (COPD) are more common in comparison with other regions of Poland. The purpose of this study was to provide a report on a prevention program carried out in the area to reduce the burden of COPD and lung cancer in the region. MATERIAL AND METHODS: The program consisted of the following: active prevention - questionnaire survey offered to every county inhabitant aged at least 40 and chest X-ray and spirometry performed in selected subjects; and passive prevention - covering multiple educational activities promoting healthy lifestyle...
October 30, 2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29081678/spatially-modeling-the-effects-of-meteorological-drivers-of-pm2-5-in-the-eastern-united-states-via-a-local-linear-penalized-quantile-regression-estimator
#8
Brook T Russell, Dewei Wang, Christopher S McMahan
Fine particulate matter (PM2.5) poses a significant risk to human health, with long-term exposure being linked to conditions such as asthma, chronic bronchitis, lung cancer, atherosclerosis, etc. In order to improve current pollution control strategies and to better shape public policy, the development of a more comprehensive understanding of this air pollutant is necessary. To this end, this work attempts to quantify the relationship between certain meteorological drivers and the levels of PM2.5. It is expected that the set of important meteorological drivers will vary both spatially and within the conditional distribution of PM2...
August 2017: Environmetrics
https://www.readbyqxmd.com/read/29050289/acrolein-induces-mtdna-damages-mitochondrial-fission-and-mitophagy-in-human-lung-cells
#9
Hsiang-Tsui Wang, Jing-Heng Lin, Chun-Hsiang Yang, Chun-Hao Haung, Ching-Wen Weng, Anya Maan-Yuh Lin, Yu-Li Lo, Wei-Shen Chen, Moon-Shong Tang
Acrolein (Acr), a highly reactive unsaturated aldehyde, can cause various lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. We have found that Acr can damage not only genomic DNA but also DNA repair proteins causing repair dysfunction and enhancing cells' mutational susceptibility. While these effects may account for Acr lung carcinogenicity, the mechanisms by which Acr induces lung diseases other than cancer are unclear. In this study, we found that Acr induces damages in mitochondrial DNA (mtDNA), inhibits mitochondrial bioenergetics, and alters mtDNA copy number in human lung epithelial cells and fibroblasts...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28987552/is-infection-an-independent-risk-factor-for-venous-thromboembolism-a-population-based-case-control-study
#10
Kevin P Cohoon, Aneel A Ashrani, Daniel J Crusan, Tanya M Petterson, Kent R Bailey, John A Heit
BACKGROUND: The independent association of recent infection with venous thromboembolism is uncertain. The purpose of the study was to test both overall infection (site unspecified) and specific infection sites as potential risk factors for deep vein thrombosis and pulmonary embolism adjusting for other known venous thromboembolism factors. METHODS: Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident deep vein thrombosis or pulmonary embolism over the 13-year period, 1988-2000 (cases; n=1303), and 1-2 residents without venous thromboembolism matched to each case on age, sex and incident venous thromboembolism date (controls; n=1494)...
October 4, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28983782/electronic-cigarettes-their-constituents-and-potential-links-to-asthma
#11
REVIEW
Phillip W Clapp, Ilona Jaspers
PURPOSE OF REVIEW: Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases...
October 5, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28971204/toward-breath-analysis-on-a-chip-for-disease-diagnosis-using-semiconductor-based-chemiresistors-recent-progress-and-future-perspectives
#12
REVIEW
Ji-Wook Yoon, Jong-Heun Lee
Semiconductor gas sensors using metal oxides, carbon nanotubes, graphene-based materials, and metal chalcogenides have been reviewed from the viewpoint of the sensitive, selective, and reliable detection of exhaled biomarker gases, and perspectives/strategies to realize breath analysis on a chip for disease diagnosis are discussed based on the concurrent design of high-performance sensing materials and miniaturized pretreatment components. Carbon-based sensing materials that show relatively high responses to NO and NH3 at low or mildly raised temperatures can be applied to the diagnosis of asthma and renal disease...
October 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28945837/nivolumab-induced-asthma-in-a-patient-with-non-small-cell-lung-cancer
#13
K Maeno, S Fukuda, T Oguri, A Niimi
No abstract text is available yet for this article.
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28925663/top-poems-of-2016-consistent-with-the-principles-of-the-choosing-wisely-campaign
#14
Roland Grad, Mark H Ebell
A challenge in the Choosing Wisely campaign is to identify low-value clinical actions supported by high-quality evidence. We applied a method based on crowdsourcing the Daily POEM (patient-oriented evidence that matters) to identify low-value clinical actions from research studies consistent with the principles of Choosing Wisely. In 2016, we analyzed an average of 1,382 questionnaires on 265 unique POEMs delivered to physician members of the Canadian Medical Association. From these questionnaires, we identified the POEMs ranking highest on one questionnaire item directly linked to reducing overdiagnosis or overtreatment...
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28883718/contributions-of-copd-asthma-and-ten-comorbid-conditions-to-health-care-utilization-and-patient-centered-outcomes-among-us-adults-with-obstructive-airway-disease
#15
Terrence E Murphy, Gail J McAvay, Heather G Allore, Jason A Stamm, Paul F Simonelli
BACKGROUND: Among persons with obstructive airway disease, the relative contributions of chronic obstructive pulmonary disease (COPD), asthma, and common comorbid conditions to health care utilization and patient-centered outcomes (PCOs) have not been previously reported. METHODS: We followed a total of 3,486 persons aged ≥40 years with COPD, asthma, or both at baseline, from the Medical Expenditure Panel Survey (MEPS) cohorts enrolled annually from 2008 through 2012 for 1 year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28831373/chronic-eosinophilic-pneumonia-after-radiation-therapy-for-squamous-cell-lung-cancer
#16
Hiromasa Nakayasu, Toshihiro Shirai, Yuko Tanaka, Mika Saigusa
Reports of chronic eosinophilic pneumonia (CEP) after radiation therapy are limited to breast cancer. We herein describe a case of CEP after radiation therapy for lung cancer. The patient was a 65-year-old man who had asymptomatic peripheral blood eosinophilia but no history of asthma or allergy. One month after completion of radiation therapy, chest CT scan revealed infiltrates inside the irradiated area, leading to the diagnosis of radiation pneumonitis. His condition improved after receiving corticosteroids...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28818625/the-therapeutic-potential-of-crth2-dp2-beyond-allergy-and-asthma
#17
REVIEW
Katharina Jandl, Akos Heinemann
Prostaglandin (PG) D2 has been in the focus of research for quite a long time, but its biological effects and its roles in human disease are still not fully characterized. When in 2001 a second major PGD2 receptor termed chemoattractant receptor homologue expressed on Th2 cells (CRTH2; alternative name DP2) was discovered, diverse investigations started to shed more light on the complex and often controversial actions of the prostaglandin. With various immunomodulating effects, such as induction of migration, activation, and cytokine release of leukocytes observed both in vivo and in vitro, CRTH2 has emerged as a promising target for the treatment of allergic diseases...
August 14, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28762660/effect-of-pre-existing-respiratory-conditions-on-survival-of-lung-cancer-patients-a-nationwide-population-based-cohort-study
#18
Seri Hong, Eun-Cheol Park, Tae Hyun Kim, Jeoung A Kwon, Ki-Bong Yoo, Kyu-Tae Han, Ji Won Yoo, Sun Jung Kim
BACKGROUND: Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS: We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model...
August 1, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28753908/correction-asthma-and-the-risk-of-lung-cancer-a-meta-analysis
#19
Yan-Liang Qu, Jun Liu, Li-Xin Zhang, Chun-Min Wu, Ai-Jie Chu, Bao-Lei Wen, Chao Ma, Xu-Yan Yan, Xin Zhang, De-Ming Wang, Xin Lv, Shu-Jian Hou
No abstract text is available yet for this article.
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28742980/disease-relevant-modifications-of-the-methylome-and-transcriptome-by-particulate-matter-pm2-5-from-biomass-combustion
#20
Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas Häupl, Marc Bonin, Regina Dornhof, Stefan Günther, Irmgard Merfort, Matjaz Humar
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 BeadChip. The transcriptome was determined by the Affymetrix HG-U133 Plus 2.0 Array. PM2.5 induced genome wide alterations of the DNA methylation pattern, including differentially methylated CpGs in the promoter region associated with CpG islands...
July 25, 2017: Epigenetics: Official Journal of the DNA Methylation Society
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