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https://www.readbyqxmd.com/read/28636457/notch-signaling-in-lung-diseases
#1
Jiehan Jiang, Kui Xiao, Ping Chen
NOTCH is a fundamental signaling system that regulates normal embryonic development and tissue homeostasis in adult life. NOTCH receptor is a single-pass transmembrane protein normally triggered via direct cell-to-cell contact, in which NOTCH ligands bind the extracellular domain of the receptor, inducing γ-secretase cleavage and release of intracellular domain. The intracellular domain binds to the transcriptional effector RBPJκ to activate transcription of target genes that regulate cell differentiation, patterning, and morphogenesis during embryonic development and adult life...
June 21, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28630636/targeting-tumor-microenvironment-effects-of-chinese-herbal-formulae-on-macrophage-mediated-lung-cancer-in-mice
#2
Fei Xu, Wenqiang Cui, Zhengxiao Zhao, Weiyi Gong, Ying Wei, Jiaqi Liu, Mihui Li, Qiuping Li, Chen Yan, Jian Qiu, Baojun Liu, Jingcheng Dong
Our previous studies have shown that Qing-Re-Huo-Xue (QRHX) formulae had significant anti-inflammatory effects in chronic airway diseases such as asthma and chronic obstructive lung disease. Here, we examined the effects of QRHX on lung cancer cell invasion and the potential associated mechanism(s), mainly polarization of macrophages in the tumor microenvironment. In vivo, QRHX both inhibited tumor growth and decreased the number of tumor-associated macrophages (TAMs) in mice with lung cancer. Further study indicated that QRHX inhibited cancer-related inflammation in tumor by decreasing infiltration of TAMs and IL-6 and TNF-α production and meanwhile decreased arginase 1 (Arg-1) expression and increased inducible NO synthase (iNOS) expression...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28629362/long-term-exposure-to-ambient-ultrafine-particles-and-respiratory-disease-incidence-in-in-toronto-canada-a-cohort-study
#3
Scott Weichenthal, Li Bai, Marianne Hatzopoulou, Keith Van Ryswyk, Jeffrey C Kwong, Michael Jerrett, Aaron van Donkelaar, Randall V Martin, Richard T Burnett, Hong Lu, Hong Chen
BACKGROUND: Little is known about the long-term health effects of ambient ultrafine particles (<0.1 μm) (UFPs) including their association with respiratory disease incidence. In this study, we examined the relationship between long-term exposure to ambient UFPs and the incidence of lung cancer, adult-onset asthma, and chronic obstructive pulmonary disease (COPD). METHODS: Our study cohort included approximately 1.1 million adults who resided in Toronto, Canada and who were followed for disease incidence between 1996 and 2012...
June 19, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28618108/chronic-respiratory-disease-in-the-regional-and-remote-population-of-the-northern-territory-top-end-a-perspective-from-the-specialist-respiratory-outreach-service
#4
Anuk Kruavit, Melissa Fox, Rebecca Pearson, Subash Heraganahally
OBJECTIVE: To study the demographic, rates and types of chronic respiratory conditions in Indigenous and non-Indigenous patients in regional and remote communities of Northern Territory Top End, who were referred to the specialist respiratory outreach service. DESIGN: A retrospective, observational study over a 2 years period. SETTING: Remote community health clinics within the Northern Territory Top End visited by the specialist respiratory outreach team...
June 15, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28612540/-prevalence-and-associated-factors-of-arthritis-in-middle-and-old-aged-populations-in-china
#5
Pei-Ya Cao, Kan Wu, Jia-Hui Qian, Hui-Qiang Luo, Xiao-Hui Ren
OBJECTIVES: To determine the prevalence of arthritis in middle- and old-aged populations in China and associated factors. METHODS: Data were drawn from the 2013 China Health and Retirement Longitudinal Study (CHARLS). Binary logistic regression analyses were performed to examine the associations of arthritis with social economic status (age, gender, areas, education), comorbidity (hypertension, dyslipidaemia, diabetes, cancer, chronic lung disease, liver disease, heart disease, stroke, kidney disease, digestive disease, asthma), lifestyle (smoking, drinking, sleeping) and mental health (depression symptoms)...
March 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28592098/-the-effect-of-short-term-exposure-to-ambient-no-2-on-lung-function-and-fractional-exhaled-nitric-oxide-in-33-chronic-obstructive-pulmonary-disease-patients
#6
J Shan, Y Ni, W Dong, J H Xu, L Pan, H Y Li, X Yang, S W Wu, Y H Chen, F R Deng, X B Guo
Objectives: To investigate the effect of short-term exposure to ambient NO(2) has influence on lung function and fractional exhaled nitric oxide (FeNO) in chronic obstructive pulmonary disease (COPD) patients. Methods: A panel of doctor-diagnosed stable COPD patients (n=33) were recruited and repeatedly measured for lung function and FeNO from December 2013 to October 2014. The patients who lived in Beijing for more than one year and aged between 60 and 85 years old were included in the study. We excluded patients with asthma, bronchial tensor, lung cancer and other respiratory disorders other than chronic obstructive pulmonary disease and occupational exposure and chest trauma surgery patients...
June 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28589151/advanced-role-of-neutrophils-in-common-respiratory-diseases
#7
REVIEW
Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, Fang Wang
Respiratory diseases, always being a threat towards the health of people all over the world, are most tightly associated with immune system. Neutrophils serve as an important component of immune defense barrier linking innate and adaptive immunity. They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential role in the pathogenesis of many respiratory diseases. However, the pathological mechanism of neutrophils remains complex and obscure. The traditional roles of neutrophils in severe asthma, chronic obstructive pulmonary diseases (COPD), pneumonia, lung cancer, pulmonary fibrosis, bronchitis, and bronchiolitis had already been reviewed...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28586276/dendritic-cell-trafficking-and-function-in-rare-lung-diseases
#8
Huan Liu, Claudia Jakubzick, Andrew R Osterburg, Rebecca L Nelson, Nishant Gupta, Francis X McCormack, Michael T Borchers
Dendritic cells (DCs) are highly specialized immune cells that capture antigens and then migrate to lymphoid tissue and present antigen to T cells. This critical function of DCs is well defined and recent studies further demonstrate that DCs are also key regulators of several innate immune responses. Studies focused on the roles of DCs in the pathogenesis of common lung diseases such as asthma, infection and cancer have traditionally driven our mechanistic understanding of pulmonary DC biology. The emerging development of novel DC reagents, techniques and genetically modified animal models has provided abundant data revealing distinct populations of DCs in the lung and allow us to examine mechanisms of DC development, migration and function in pulmonary disease with unprecedented detail...
June 6, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28585921/detection-of-lung-cancer-in-exhaled-breath-with-electronic-nose-using-support-vector-machine-analysis
#9
Madara Tirzīte, Māris Bukovskis, Gunta Strazda, Normunds Jurka, Immanuels Taivans
Lung cancer is one of the most common malignancies with a low five-year survival rate. There are no cheap, simple and widely available screening methods for early diagnostics of lung cancer. The aim of the study was to determine whether analysis of the exhaled breath with an artificial olfactory sensor using support vector analysis can differentiate lung cancer patients from healthy individuals and patients with other lung diseases regardless of the stage of lung cancer and the most common comorbidities...
June 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28584492/prevalence-of-exposure-to-secondhand-smoke-among-higher-secondary-school-students-in-ernakulam-district-kerala-southern-india
#10
P S Rakesh, Jishnu Satheesh Lalu, K Leelamoni
INTRODUCTION: The association between secondhand smoke and health outcomes, such as frequent respiratory infections, ischemic heart disease, lung cancer, asthma, and stroke, has long been established. The study aimed to estimate the prevalence of secondhand smoking exposure among higher secondary school students in Ernakulam district, Kerala, Southern India. MATERIALS AND METHODS: A structured questionnaire was administered to all students from four randomly selected higher secondary schools in Ernakulam district...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28573192/modeling-the-effect-of-the-aryl-hydrocarbon-receptor-on-transplant-immunity
#11
Walker Julliard, John H Fechner, Leah Owens, Chelsea A O'Driscoll, Ling Zhou, Jeremy A Sullivan, Lynn Frydrych, Amanda Mueller, Joshua D Mezrich
BACKGROUND: Exposure to pollutants through inhalation is a risk factor for lung diseases including cancer, asthma, and lung transplant rejection, but knowledge of the effects of inhaled pollutants on pathologies outside of the lung is limited. METHODS: Using the minor-mismatched model of male C57BL/6J (B6) to female B6 skin grafts, recipient mice were treated with an inhaled urban dust particle sample every 3 days before and after grafting. Graft survival time was determined, and analysis of the resulting immune response was performed at time before rejection...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28542165/subtypes-of-native-american-ancestry-and-leading-causes-of-death-mapuche-ancestry-specific-associations-with-gallbladder-cancer-risk-in-chile
#12
Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28529457/deguelin-attenuates-allergic-airway-inflammation-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-in-mice
#13
Zhang Bao, Pei Zhang, Yinan Yao, Guohua Lu, Zhongkai Tong, Bing Yan, Lingfang Tu, Guangdie Yang, Jianying Zhou
Asthma is a chronic respiratory disease characterized by airway inflammation and remodeling, resulting in a substantial economic burden on both patients and society. Deguelin, a constituent of the Leguminosae family, exhibits anti-proliferative and anti-inflammatory activities in cancer mice models via inhibiting phosphatidylinositol 3-kinases and the NF-κB pathway. We demonstrated that deguelin effectively reduced OVA-induced inflammatory cell recruitment, decreased lung tissue inflammation and mucus production, suppressed airway hyperresponsiveness, and inhibited serum immunoglobulin and Th2 cytokine levels in a dose-dependent manner in asthmatic mice...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28495571/role-of-iron-in-the-pathogenesis-of-respiratory-disease
#14
REVIEW
Md Khadem Ali, Richard Y Kim, Rafia Karim, Jemma R Mayall, Kristy L Martin, Ali Shahandeh, Firouz Abbasian, Malcolm R Starkey, Veronique Loustaud-Ratti, Daniel Johnstone, Elizabeth A Milward, Philip M Hansbro, Jay C Horvat
Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma...
May 7, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28485358/opium-consumption-a-potential-risk-factor-for-lung-cancer-and-pulmonary-tuberculosis
#15
A Safari, M Reazai, A Tangestaninejad, A R Mafi, Saj Mousavi
OBJECTIVE: Lung cancer is the most common malignancy, as well as the leading cause of cancer-related mortality worldwide. Several studies have shown the causative effect of cigarettes smoking in lung cancer, however, the effect of opium consumption has not yet been well studied. This study has been designed to evaluate the risk of developing lung cancer and pulmonary tuberculosis in pure opium addicts. MATERIALS AND METHODS: We designed an analytic case-control study with 490 participants...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28470547/disparities-in-us-healthcare-provider-screening-and-advice-for-cessation-across-chronic-medical-conditions-and-tobacco-products
#16
Diana R Keith, Cassandra A Stanton, Diann E Gaalema, Janice Y Bunn, Nathan J Doogan, Ryan Redner, Allison N Kurti, Antonio Cepeda-Benito, Alexa A Lopez, Adam L Morehead, Megan E Roberts, Stephen T Higgins
BACKGROUND: Disparities in tobacco use are worsening in the United States, disproportionately affecting those with chronic medical conditions. One possible contributor is that physicians may not screen and advise cessation uniformly across patients and/or tobacco products. OBJECTIVE: This study examined provider communications regarding cigarette and non-cigarette tobacco products among adults with chronic conditions. DESIGN: Cross-sectional study drawn from two waves (2013-2014) of the National Survey on Drug Use and Health (NSDUH)...
May 3, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28469671/gender-estrogen-and-obliterative-lesions-in-the-lung
#17
REVIEW
Hamza Assaggaf, Quentin Felty
Gender has been shown to impact the prevalence of several lung diseases such as cancer, asthma, chronic obstructive pulmonary disease, and pulmonary arterial hypertension (PAH). Controversy over the protective effects of estrogen on the cardiopulmonary system should be of no surprise as clinical trials of hormone replacement therapy have failed to show benefits observed in experimental models. Potential confounders to explain these inconsistent estrogenic effects include the dose, cellular context, and systemic versus local tissue levels of estrogen...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28462210/the-expression-of-proline-specific-enzymes-in-the-human-lung
#18
REVIEW
Gwendolyn Vliegen, Tom K Raju, Dirk Adriaensen, Anne-Marie Lambeir, Ingrid De Meester
The pathophysiology of lung diseases is very complex and proteolytic enzymes may play a role or could be used as biomarkers. In this review, the literature was searched to make an overview of what is known on the expression of the proline-specific peptidases dipeptidyl peptidase (DPP) 4, 8, 9, prolyl oligopeptidase (PREP) and fibroblast activation protein α (FAP) in the healthy and diseased lung. Search terms included asthma, chronic obstructive pulmonary disease (COPD), lung cancer, fibrosis, ischemia reperfusion injury and pneumonia...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28461167/singing-lessons-for-respiratory-health-a-literature-review
#19
REVIEW
Rachel B Goldenberg
OBJECTIVE: Several studies have explored the role of music and singing as a treatment for respiratory symptoms. The objective of this paper was to review the current body of literature in regard to the use of singing as both a physiological and a psychological therapy for respiratory disease and assess the role the singing teacher might play in this treatment. STUDY DESIGN: This is a literature review, discussion of results and directions for further research. METHOD: Multiple databases were searched using keywords such as "respiratory," "physiotherapy," and "pulmonary" in conjunction with "singing...
April 28, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28431562/effects-of-the-common-polymorphism-in-the-human-aldehyde-dehydrogenase-2-aldh2-gene-on-the-lung
#20
Aoi Kuroda, Ahmed E Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima, Tomoko Betsuyaku
BACKGROUND: Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2*2) results in inactivation of the enzyme and is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer's diseases and some cancers. The effect of this ALDH2 polymorphism on the lung and its stem cells has not been thoroughly examined...
April 21, 2017: Respiratory Research
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