keyword
MENU ▼
Read by QxMD icon Read
search

allergic cancer

keyword
https://www.readbyqxmd.com/read/29314003/atopic-allergic-conditions-and-pancreatic-cancer-risk-results-from-the-multiethnic-cohort-study
#1
Brian Z Huang, Loic Le Marchand, Christopher A Haiman, Kristine R Monroe, Lynne R Wilkens, Zuo-Feng Zhang, Veronica Wendy Setiawan
Previous case-control studies have suggested that atopic allergic conditions (AACs) are inversely associated with pancreatic cancer, but this relationship has not been supported in many prospective settings. In this study, we investigated the influence of AACs (asthma, hay fever, or allergy) and the treatment of these conditions on pancreatic cancer risk among participants of the Multiethnic Cohort Study (MEC). AACs and antihistamine use were assessed via a baseline questionnaire when participants joined the MEC in 1993-1996...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29244250/human-innate-lymphoid-cells-ilcs-towards-a-uniform-immune-phenotyping
#2
REVIEW
Sara Trabanelli, Alejandra Gomez Cadena, Domenico Mavilio, Basile Nicolas Landis, Peter Jandus, Camilla Jandus
Helper Innate Lymphoid Cells (ILCs), the most recently identified population of the Innate Lymphoid Cell family, plays a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2 and ILC3, that can be specifically activated by different signals coming either from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions...
December 15, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29241139/mussels-and-clams-from-the-italian-fish-market-is-there-a-human-exposition-risk-to-metals-and-arsenic
#3
L M Chiesa, F Ceriani, M Caligara, D Di Candia, R Malandra, S Panseri, F Arioli
Seafood is associated with many beneficial effects on human health. However, the overall level of contaminants in biota has increased over the last two centuries and seafood is one of the source of oral exposition to contaminants. Therefore, this work aimed to evaluate cadmium, lead, mercury, arsenic, chromium and nickel presence in mussels and clams, from the Italian market, and the associated risk. The samples were from five different FAO areas. Analyses were carried out using inductively-coupled plasms-mass spectrometry...
December 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#4
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B) / RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29216544/crystal-structures-of-murine-and-human-histamine-releasing-factor-hrf-tctp-and-a-model-for-hrf-dimerisation-in-mast-cell-activation
#5
Katy A Doré, Jun-Ichi Kashiwakura, James M McDonnell, Hannah J Gould, Toshiaki Kawakami, Brian J Sutton, Anna M Davies
In allergic disease, mast cell activation is conventionally triggered by allergen-mediated cross-linking of receptor-bound IgE on the cell surface. In addition to its diverse range of intracellular roles in apoptosis, cell proliferation and cancer, Histamine-Releasing Factor (HRF) also activates mast cells and basophils. A subset of IgE antibodies bind HRF through their Fab regions, and two IgE binding sites on HRF have been mapped. HRF can form dimers, and a disulphide-linked dimer is critical for activity...
December 4, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29193236/inhibitory-effect-of-naringenin-via-il-13-level-regulation-on-thymic-stromal-lymphopoietin-induced-inflammatory-reactions
#6
Na-Ra Han, Phil-Dong Moon, Ka-Jung Ryu, Na-Rae Kim, Hyung-Min Kim, Hyun-Ja Jeong
Naringenin (NG) has various beneficial properties, such as anti-cancer and anti-inflammatory effects. Thymic stromal lymphopoietin (TSLP) induces mast cell proliferation and inflammatory reactions. The aim of this study was to investigate the regulatory effect of NG on TSLP-induced mast cell proliferation and inflammatory reactions using human mast cell line (HMC-1) cells. HMC-1 cells were pre-treated with NG and then treated with TSLP. HMC-1 cells proliferation was determined by quantifying bromodeoxyuridine incorporation...
November 29, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29187726/expression-of-interleukin-27-il-27-in-the-lower-airways-diseases-increased-levels-of-il-27-in-early-clinical-stages-of-non-small-cell-lung-cancer-nsclc-patients
#7
Piotr Kopiński, Tomasz Wandtke, Andrzej Dyczek, Ewelina Wędrowska, Adriana Roży, Tomasz Senderek, Grzegorz Przybylski, Joanna Chorostowska-Wynimko
INTRODUCTION    Interleukin-27, is a cytokine secreted mostly by antigen presenting cells, key for the Th1 cells immune polarization. Its role in interstitial lung diseases (ILD) as well as in lung cancer has been investigated.  OBJECTIVES    Assessment of IL-27 expression in the lower airways of patients with selected ILD and early-stage non-small cell lung cancer (NSCLC).  PATIENTS AND METHODS    IL-27 concentration was examined by ELISA in bronchoalveolar lavage (BAL) supernatants collected from patients with pulmonary sarcoidosis (PS), extrinsic allergic alveolitis (EAA), idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP) and I-IIa NSCLC with peripheral localization, as well as in control subjects (n = 14, 30, 12, 14, 16 and 14, respectively)...
November 29, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29180206/ropivacaine-wound-infiltration-a-fast-track-approach-in-patients-undergoing-thoracotomy-surgery
#8
Zhuqing Rao, Haoming Zhou, Xiongxiong Pan, Jing Chen, Yuting Wang, Zhongyun Wang, Zhengnian Ding
BACKGROUND: Postoperative pain impairs enhanced recovery in patients after various surgeries. Local use of ropivacaine has become an effective strategy for postoperative pain management. The aim of this study was to assess the effectiveness and safety of wound infiltration with ropivacaine for postoperative analgesia as a fast-track approach in patients undergoing thoracotomy surgery. MATERIALS AND METHODS: Forty adult patients with esophageal cancer scheduled for selective thoracotomy surgery were enrolled in this double-blind, randomized, controlled study...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29163536/drug-hypersensitivity-and-anaphylaxis-in-cancer-and-chronic-inflammatory-diseases-the-role-of-desensitizations
#9
REVIEW
Mariana Castells
Drug allergy is a rising problem in the twenty-first century which affects all populations and races, children, and adults, and for which the recognition, diagnosis, management, and treatment is still not well standardized. Classical and new chemotherapy drugs, monoclonal antibodies (MoAbs), and small molecules to treat cancer and chronic inflammatory diseases are aimed at improving quality of life and life expectancy of patients, but an increasing number of reactions including anaphylaxis precludes their use in targeted populations...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29158348/galectin-1-a-jack-of-all-trades-in-the-resolution-of-acute-and-chronic-inflammation
#10
REVIEW
Victoria Sundblad, Luciano G Morosi, Jorge R Geffner, Gabriel A Rabinovich
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation...
December 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29150085/pinocembrin-alleviates-cognition-deficits-by-inhibiting-inflammation-in-diabetic-mice
#11
Bing Pei, Jian Sun
Diabetic encephalopathy (DE) is one of the most common diabetic complications in diabetes mellitus and is characterized by cognitive impairment and neuroinflammation. It has been reported that hyperglycemia can induce hippocampal and cortical neuronal damage, which can result in severe spatial learning and memory impairment. Pinocembrin (Pino) has been widely used in the therapy of cancer and other diseases due to its anti-inflammatory, anti-allergic, anti-oxidant, anti-carcinogenic, and anti-viral activities...
November 8, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29128708/childhood-brain-tumours-early-infections-and-immune-stimulation-a-pooled-analysis-of-the-escale-and-estelle-case-control-studies-sfce-france
#12
Judith E Lupatsch, Helen D Bailey, Brigitte Lacour, Christelle Dufour, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, François Doz, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel
BACKGROUND: Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. METHODS: We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies...
November 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29113093/view-point-semaphorin-3e-an-emerging-modulator-of-natural-killer-cell-functions
#13
REVIEW
Abdulaziz Alamri, Abdelilah Soussi Gounni, Sam K P Kung
Semaphorin-3E (Sema-3E) is a member of a large family of proteins originally identified as axon guidance cues in neural development. It is expressed in different cell types, such as immune cells, cancer cells, neural cells, and epithelial cells. Subsequently, dys-regulation of Sema-3E expression has been reported in various biological processes that range from cancers to autoimmune and allergic diseases. Recent work in our laboratories revealed a critical immunoregulatory role of Sema-3E in experimental allergic asthma...
November 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29108766/new-insight-into-cancer-immunotherapy
#14
REVIEW
M M Escribese, D Barber
A key point for maintenance of the immune system homeostasis is the balance between the capacity to recognize and fight exogenous molecules and the capacity to avoid auto reactivity. The disruption of this balance induces the progression of several immune diseases such as autoimmune diseases, allergies, infections or cancer. A promising therapeutic approach to treat these diseases is immunotherapy. In cancer, both active and passive immunotherapies have been tested with promising results, such as the blocking of immunological checkpoints like CTLA-4 and PD-1...
November 3, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29096643/comparison-of-sentinel-lymph-node-biopsy-guided-by-indocyanine-green-blue-dye-and-their-combination-in-breast-cancer-patients-a-prospective-cohort-study
#15
Jiajia Guo, Houpu Yang, Shu Wang, Yingming Cao, Miao Liu, Fei Xie, Peng Liu, Bo Zhou, Fuzhong Tong, Lin Cheng, Hongjun Liu, Siyuan Wang
BACKGROUND: Recent studies show that near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve the performance of sentinel lymph node (SLN) mapping. The current cohort study was designed to assess the value of the combination of ICG and methylene blue (MB) dye in patients undergoing SLN biopsy. METHODS: A prospective self-controlled trial was designed to detect the difference in the detection efficacies of ICG, MB, and combined ICG and MB (ICG + MB) navigation methods...
November 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29092096/retrospective-study-of-hypersensitivity-reactions-to-chemotherapeutic-agents-in-a-thoracic-oncology-service
#16
H Capelle, C Tummino, L Greillier, M Gouitaa, J Birnbaum, N Ausias, F Barlesi, M Montana
WHAT IS KNOWN AND OBJECTIVE: With the increasing use of cancer chemotherapy agents, hypersensitivity reactions are commonly encountered. The allergic clinical symptoms are variable and unpredictable. The aim of this study was to identify the characteristics of hypersensitivity reactions and to assess the value of skin tests for platinum salts and pemetrexed in the treatment of patients with non-small cell lung cancers or malignant pleural mesothelioma. METHODS: A single-centre retrospective study was performed for 2 years...
November 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29091265/mouse-eosinophils-identification-isolation-and-functional-analysis
#17
Hadar Reichman, Perri Rozenberg, Ariel Munitz
Eosinophils are bone marrow-derived cells that differentiate in the bone marrow and migrate into the peripheral blood primarily under the regulation of interleukin (IL)-5. Eosinophil levels in the blood are relatively low. However, under steady-state conditions and in settings of allergic inflammation, parasite infections, or even cancer, they migrate and mainly reside in mucosal tissues where they have key effector and immune-modulating functions. Functional studies using eosinophils are not simple, since these cells are terminally differentiated and rapidly die in vitro...
November 1, 2017: Current Protocols in Immunology
https://www.readbyqxmd.com/read/29083346/indoors-and-health-results-of-a-systematic-literature-review-assessing-the-potential-health-effects-of-living-in-basements
#18
Angelo Giosué Mezzoiuso, Marco Gola, Andrea Rebecchi, Matteo Riccò, Stefano Capolongo, Maddalena Buffoli, Marcello Tirani, Anna Odone, Carlo Signorelli
A new law approved in March 2017 in the Lombardy Region makes it possible to live in basements. Basements are defined as buildings partly below curb level but with at least one-half of its height above the curb. Basements' features and structural characteristics might pose risks to human health. In this paper we adopt a multidisciplinary approach to assess the potential health effects of living in basements. In particular, we define a conceptual framework to describe basements' structural characteristics which are risk factors, as well as the mechanisms through which they impact on human health...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29073213/cytokine-induced-killer-cells-a-novel-treatment-for-allergic-airway-inflammation
#19
Panwadee Pluangnooch, Sunita Timalsena, Adisak Wongkajornsilp, Kitipong Soontrapa
The effectiveness of cytokine-induced killer (CIK) cells for treatment of cancers has long been appreciated. Here, we report for the first time that CIK cells can be applied to treat allergic airway inflammation. Adopting from an established protocol with some modifications, we generated CIK cells ex vivo from mouse T cells, and examined their effectiveness in treatment of allergic airway inflammation using the ovalbumin-induced model of allergic airway inflammation. Based upon evaluation of bronchoalveolar lavage cellularity, T helper type2 cytokine levels and lung histology, all of which are important parameters for determining the severity of allergic airway inflammation, diseased mice treated with CIK cells showed significant reductions in all the parameters without any obvious adverse effects...
2017: PloS One
https://www.readbyqxmd.com/read/29038115/the-common-cytokine-receptor-%C3%AE-chain-family-of-cytokines
#20
Jian-Xin Lin, Warren J Leonard
Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their sharing the common cytokine receptor γ chain (γc), which was originally discovered as the third receptor component of the IL-2 receptor, IL-2Rγ. The IL2RG gene is located on the X chromosome and is mutated in humans with X-linked severe combined immunodeficiency (XSCID). The breadth of the defects in XSCID could not be explained solely by defects in IL-2 signaling, and it is now clear that γc is a shared receptor component of the six cytokines noted above, making XSCID a disease of defective cytokine signaling...
October 16, 2017: Cold Spring Harbor Perspectives in Biology
keyword
keyword
56756
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"