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https://www.readbyqxmd.com/read/29777684/repositioning-of-anti-cancer-drug-candidate-azd7762-to-an-anti-allergic-drug-suppressing-ige-mediated-mast-cells-and-allergic-responses-via-the-inhibition-of-lyn-and-fyn
#1
Young Hwan Park, Do Kyun Kim, Hyun Woo Kim, Hyuk Soon Kim, Dajeong Lee, Min Bum Lee, Keun Young Min, Jimo Koo, Su Jeong Kim, Changhee Kang, Young Mi Kim, Hyung Sik Kim, Wahn Soo Choi
Mast cells are critical effector cells in IgE-mediated allergic responses. The aim of this study was to investigate the anti-allergic effects of 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide (AZD7762) in vitro and in vivo. AZD7762 inhibited the antigen-stimulated degranulation from RBL-2H3 (IC50 , ∼ 27.9 nM) and BMMCs (IC50 , ∼ 99.3 nM) in a dose-dependent manner. AZD7762 also inhibited the production of TNF-α and IL-4. As the mechanism of its action, AZD7762 inhibited the activation of Syk and its downstream signaling proteins, such as Linker of activated T cells (LAT), phospholipase (PL) Cγ1, Akt, and mitogen-activated protein (MAP) kinases (Erk1 / 2, p38, and JNK) in mast cells...
May 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29761396/macrophage-bactericidal-assays
#2
Mourad Aribi
The search for the bactericidal activity of macrophage (Mϕ) is crucial not only during infection, but also to explore its functional activities in normal and pathological conditions, such as autoimmune and inflammatory disorders, allergic inflammation, and cancer. There are several methods exploring the phagocytic and bactericidal activities of Mϕ. This chapter focuses specifically on the technique called antibiotic protection assay and on the methods for the determination of Mϕ production of nitric oxide and hydrogen peroxide as antimicrobial agents and biomarkers of respiratory burst...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29747740/auraptene-regulates-th-1-th-2-t-reg-balances-nf-%C3%AE%C2%BAb-nuclear-localization-and-nitric-oxide-production-in-normal-and-th-2-provoked-situations-in-human-isolated-lymphocytes
#3
Vahid Reza Askari, Vafa Baradaran Rahimi, Seyed Abdolrahim Rezaee, Mohammad Hossein Boskabady
BACKGROUND: Auraptene as member of dietary coumarins, is found in citrus fruits. Former studies have demonstrated its anti-inflammatory and anti-cancer activity. PURPOSE: The mechanism of action and immune-modulatory property of this compound on human lymphocytes are greatly unknown. STUDY DESIGN/METHODS: The effect of three concentrations (10, 30 and 90 µM) of auraptene or dexamethasone (0.1 mM) were evaluated on percentage of cell proliferation and nitric oxide (NO) production as well as secretion and gene expression of cytokines, and NF-κB level in PHA-stimulated and non-stimulated lymphocytes...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29745932/analysis-of-tolerance-and-security-of-chemo-hyperthermia-with-mitomycin-c-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#4
Juan León-Mata, José Luis Domínguez, Joan Palou Redorta, Daniel Sousa González, María Alvarez Casal, Alejandro Sousa Escandón, Eva Piñeiro Vázquez
OBJECTIVES: The treatment of non muscle invasive bladder cancer (NMIBC) continues to be a challenge. Hyperthermia (HT) combined with intravesical chemotherapy is used to enhance the effects of chemotherapy. METHODS: A review of the publications was carried out to synthesize the adverse effects (AE) reported by the use of chemohyperthermia (QHT) with Mitomycin-C (MMC). The most relevant data are exposed for each of the devices currently used in the QHT. RESULTS: SYNERGO®: The dropout rate varied between 3-40%, and the AE rate is up to 88%...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29738847/ethnopharmacological-uses-phytochemistry-biological-activities-and-therapeutic-applications-of-alpinia-oxyphylla-miquel-a-review
#5
REVIEW
Qiao Zhang, Yunliang Zheng, Xingjiang Hu, Xiaolong Hu, Wenwen Lv, Duo Lv, Jinjin Chen, Minglan Wu, Qichao Song, Jianzhong Shentu
ETHNOPHARMACOLOGICAL USAGES: Fructus Alpiniae oxyphyllae (A. oxyphylla) is an important medicinal plant that is used not only as an edible fruit, but also as an important traditional medicine for benefiting cognitive performance and alleviating a wide spectrum of diseases. Such as; warming kidney, securing essence and arresting polyuria, as well as warming the spleen and stopping diarrhea and saliva. AIMS: The purpose of this review is to provide updated, comprehensive and categorized information on the traditional uses, phytochemistry and pharmacological research of A...
May 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29714636/extracellular-vesicles-released-in-response-to-respiratory-exposures-implications-for-chronic-disease
#6
Birke J Benedikter, Emiel F M Wouters, Paul H M Savelkoul, Gernot G U Rohde, Frank R M Stassen
Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes)...
May 1, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29707294/lipoxin-a4-regulates-pm2-5-induced-severe-allergic-asthma-in-mice-via-the-th1-th2-balance-of-group-2-innate-lymphoid-cells
#7
Xiaoxia Lu, Huicong Fu, Feng Han, Yurong Fang, Jiali Xu, Liqiong Zhang, Qing Du
Background: Urban particulate matter (PM) contributes to the increasing number of people with asthma, which is closely related to the development of industrialization. Especially, PM with an aerodynamic diameter of <2.5 µm (PM2.5) enhances the risk of damaging respiratory organs. It has reported that PM2.5-induced pathological changes could be considered as a remarkable molecular mechanism of PM2.5-mediated cytotoxicity in respiratory disease and even lung cancer. Methods: In this study, we have investigated the effects of PM2...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29691472/production-and-delivery-of-helicobacter-pylori-napa-in-lactococcus-lactis-and-its-protective-efficacy-and-immune-modulatory-activity
#8
Xiaoyan Peng, Rongguang Zhang, Guangcai Duan, Chen Wang, Nan Sun, Linghan Zhang, Shuaiyin Chen, Qingtang Fan, Yuanlin Xi
Helicobacter pylori neutrophil-activating protein A subunit (NapA) has been identified as a virulence factor, a protective antigen and a potent immunomodulator. NapA shows unique application potentials for anti-H. pylori vaccines and treatment strategies of certain allergic diseases and carcinomas. However, appropriate production and utilization modes of NapA still remain uncertain to date. This work has established a novel efficient production and utilization mode of NapA by using L. lactis as an expression host and delivery vector, and demonstrated immune protective efficacy and immune modulatory activity of the engineered L...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29675545/a-novel-approach-to-improving-ambulatory-outpatient-management-of-low-risk-febrile-neutropenia-an-enhanced-supportive-care-esc-clinic
#9
Tim Cooksley, Geraldine Campbell, Tamer Al-Sayed, Lisa LaMola, Richard Berman
PURPOSE: Outpatient management of low risk febrile neutropenia patients (LRFN) identified by the MASCC score is a safe and effective strategy. Early supportive care has been shown to improve outcomes in patients with care. We developed an innovative ambulatory outpatient "enhanced supportive care" (ESC) clinic combining emergency oncology and supportive care through which we incorporated the management of patients with LRFN. METHODS: An ESC clinic was started in January 2017 at a tertiary cancer hospital in the North West of England...
April 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29621558/changes-in-gene-expression-in-lungs-of-mice-exposed-to-traffic-related-air-pollution
#10
Yang Jie, Yi Chen, Zhi Yu, Hui Ding, Zhongfu Ma
Long-term exposure to traffic-related pollutants can lead to a variety of respiratory diseases, including inflammation, asthma, and lung cancer; however, the underlying biological mechanisms are not fully understood. We focused on the effects of exposure to different air pollutants on the expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer. In order to understand the cellular responses induced by exposure to different traffic-related pollutants, we performed PCR array to evaluate the mRNA expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer in the lungs of mice exposed to three different environments, including the laboratory (clean air), and polluted parking garages in Foshan and Guangzhou for four weeks...
April 2, 2018: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29619379/eosinophils-from-physiology-to-disease-a-comprehensive-review
#11
REVIEW
Giuseppe A Ramirez, Mona-Rita Yacoub, Marco Ripa, Daniele Mannina, Adriana Cariddi, Nicoletta Saporiti, Fabio Ciceri, Antonella Castagna, Giselda Colombo, Lorenzo Dagna
Despite being the second least represented granulocyte subpopulation in the circulating blood, eosinophils are receiving a growing interest from the scientific community, due to their complex pathophysiological role in a broad range of local and systemic inflammatory diseases as well as in cancer and thrombosis. Eosinophils are crucial for the control of parasitic infections, but increasing evidence suggests that they are also involved in vital defensive tasks against bacterial and viral pathogens including HIV...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29604393/mini-review-cancer-letters-micrornas-in-type-2-immunity
#12
Kristina Johansson, Julie Weidner, Madeleine Rådinger
Type 2 immunity drives the pathology of allergic diseases and is necessary for expulsion of parasitic worms as well as having important implications in tumor progression. Over the last decade, a new research field has emerged describing a significant link between type 2 immunity and cancer development, called AllergoOncology. Thus, type 2 immune responses must be carefully regulated to mediate effective protection against damaging environmental factors, yet avoid excessive activation and immunopathology. Regulation of gene expression by microRNAs is required for normal behavior of most mammalian cells and has been studied extensively in the context of cancer...
March 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29602023/-what-the-mind-does-not-know-the-eyes-do-not-see-placing-food-allergy-risk-in-sub-saharan-africa
#13
George A Atiim, Susan J Elliott, Ann E Clarke, Craig Janes
Policy makers and health geographers are increasingly intrigued by the global rise of chronic disease. While current engagement coalesce around cardiovascular disease, cancers, chronic respiratory disease, and diabetes, very little attention has been given to other important chronic conditions: e.g., allergic disease. Concerns about how health is shaped by context and experienced in place can provide important insights to understand the trajectory of allergic disease and inform policy especially in developing countries experiencing an epidemiologic transition...
March 27, 2018: Health & Place
https://www.readbyqxmd.com/read/29577050/anticancer-drugs-induced-severe-adverse-cutaneous-drug-reactions-an-updated-review-on-the-risks-associated-with-anticancer-targeted-therapy-or-immunotherapies
#14
REVIEW
Chau Yee Ng, Chun-Bing Chen, Ming-Ying Wu, Jennifer Wu, Chih-Hsun Yang, Rosaline Chung-Yee Hui, Ya-Ching Chang, Chun-Wei Lu
Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) with increase morbidity and mortality while they are receiving cancer treatments, have been proposed to be a result of direct skin toxicity or drug hypersensitivity reactions (these are proposed mechanism, not definite)...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29568026/insufficient-evidence-for-interventions-to-prevent-dry-mouth-and-salivary-gland-dysfunction-post-head-and-neck-radiotherapy
#15
Debra M Ferraiolo, Analia Veitz-Keenan
Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CINAHL, EBSCO (Cumulative Index to Nursing and Allied Health Literature, LILACS, BIREME, Virtual Health Library (Latin American and Caribbean Health Science Information database), Zetoc Conference Proceedings, the US National Institutes of Health Ongoing Trials Register, (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform for ongoing trials...
March 23, 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29567622/th9-lymphocytes-and-functions-of-interleukin-9-with-the-focus-on-ibd-pathology
#16
REVIEW
Krzysztof Matusiewicz, Barbara Iwańczak, Małgorzata Matusiewicz
The work presents the newest knowledge on a new phenotype of T helper lymphocytes (Th9) and on Interleukin 9 (IL-9). Processes leading to transformation of naïve T lymphocyte into Th9 lymphocytes are presented, including the role of IL-4 and TGFβ signaling. Involvement of transcription factor network in production of IL-9 is described. Other cells capable of expressing IL-9 and secreting IL-9 are portrayed. Diversity of IL-9 effects caused by activation of IL-9 receptors on various types of cells is presented...
March 19, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29562712/estimation-of-the-burden-of-serious-human-fungal-infections-in-malaysia
#17
Rukumani Devi Velayuthan, Chandramathi Samudi, Harvinder Kaur Lakhbeer Singh, Kee Peng Ng, Esaki M Shankar, David W Denning
Fungal infections (mycoses) are likely to occur more frequently as ever-increasingly sophisticated healthcare systems create greater risk factors. There is a paucity of systematic data on the incidence and prevalence of human fungal infections in Malaysia. We conducted a comprehensive study to estimate the burden of serious fungal infections in Malaysia. Our study showed that recurrent vaginal candidiasis (>4 episodes/year) was the most common of all cases with a diagnosis of candidiasis ( n = 501,138). Oesophageal candidiasis ( n = 5850) was most predominant among individuals with HIV infection...
March 19, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#18
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29541215/wogonoside-inhibits-cell-growth-and-induces-mitochondrial-mediated-autophagy-related-apoptosis-in-human-colon-cancer-cells-through-the-pi3k-akt-mtor-p70s6k-signaling-pathway
#19
Chengzheng Han, Guozheng Xing, Mengying Zhang, Min Zhong, Zhen Han, Chiyi He, Xiaoping Liu
Wogonoside, the main effective constituent of traditional Chinese medicine Scutellaria , belongs to the glucuronide family, with various functions, including detoxification, anti-inflammation and nourishing gallbladder, lowering blood pressure, diuresis and anti-allergic reactions. However, the effects of wogonoside on human colon cancer cells remain unclear. The present study aimed to investigate the anticancer effect of wogonoside on human colon cancer cells in vitro and its anticancer mechanisms. The results demonstrated that wogonoside significantly inhibited cell growth, induced apoptosis and mitochondrial-mediated autophagy of colon cancer cells...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29509960/dock2-in-the-development-of-inflammation-and-cancer
#20
REVIEW
Yayun Chen, Fan Meng, Bingyu Wang, Liangmei He, Yangbin Liu, Zhiping Liu
An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic diseases, HIV infection, and graft rejection in organ transplantation. DOCK2 mutation in infants was recently identified to be associated with T and B cell combined immunodeficiency. Furthermore, Dock2 is involved in host protection during enteric bacterial infection and is also associated with the proliferation of cancer cells...
March 6, 2018: European Journal of Immunology
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