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JOURNAL ARTICLE
Son Ngoc Do, Chinh Quoc Luong, Dung Thi Pham, My Ha Nguyen, Nga Thi Nguyen, Dai Quang Huynh, Quoc Trong Ai Hoang, Co Xuan Dao, Trung Minh Le, Ha Nhat Bui, Hung Tan Nguyen, Hai Bui Hoang, Thuy Thi Phuong Le, Lien Thi Bao Nguyen, Phuoc Thien Duong, Tuan Dang Nguyen, Yen Hai Vu, Giang Thi Tra Pham, Tam Van Bui, Thao Thi Ngoc Pham, Hanh Trong Hoang, Cuong Van Bui, Nguyen Minh Nguyen, Giang Thi Huong Bui, Thang Dinh Vu, Nhan Duc Le, Trang Huyen Tran, Thang Quang Nguyen, Vuong Hung Le, Chi Van Nguyen, Bryan Francis McNally, Jason Phua, Anh Dat Nguyen
Sepsis is the most common cause of in-hospital deaths, especially from low-income and lower-middle-income countries (LMICs). This study aimed to investigate the mortality rate and associated factors from sepsis in intensive care units (ICUs) in an LMIC. We did a multicenter cross-sectional study of septic patients presenting to 15 adult ICUs throughout Vietnam on the 4 days representing the different seasons of 2019. Of 252 patients, 40.1% died in hospital and 33.3% died in ICU. ICUs with accredited training programs (odds ratio, OR: 0...
September 23, 2021: Scientific Reports
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JOURNAL ARTICLE
Ser Hon Puah, Andrew Li, Matthew Edward Cove, Jason Phua, Vicky Ng, Amit Kansal, Qiao Li Tan, Juliet Tolentino Sahagun, Juvel Taculod, Addy Yong-Hu Tan, Amartya Mukhopadhyay, Chee Kiang Tay, Kollengode Ramanathan, Yew Woon Chia, Duu Wen Sewa, Meiying Chew, Sennen J W Lew, Shirley Goh, Shekhar Dhanvijay, Jonathan Jit-Ern Tan, Kay Choong See
BACKGROUND: Use of high-flow nasal cannula (HFNC) has become a regular intervention in the intensive care units especially in patients coming in with hypoxaemic respiratory failure. Clinical practices may differ from published literature. OBJECTIVES: The objective of this study was to determine the clinical practices of physicians and respiratory therapists (RTs) on the use of HFNC. METHODS: A retrospective observational study looking at medical records on HFNC usage from January 2015 to September 2017 was performed and was followed by a series of questions related to HFNC practices...
September 10, 2021: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
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JOURNAL ARTICLE
Sunitha Palanidurai, Jason Phua, Yiong Huak Chan, Amartya Mukhopadhyay
BACKGROUND: The current Berlin definition of acute respiratory distress syndrome (ARDS) uses the PaO2 /FiO2 (P/F) ratio to classify severity. However, for the same P/F ratio, a patient on a higher positive end-expiratory pressure (PEEP) may have more severe lung injury than one on a lower PEEP. OBJECTIVES: We designed a new formula, the P/FP ratio, incorporating PEEP into the P/F ratio and multiplying with a correction factor of 10 [(PaO2 *10)/(FiO2 *PEEP)], to evaluate if it better predicts hospital mortality compared to the P/F ratio post-intubation and to assess the resultant changes in severity classification of ARDS...
August 9, 2021: Annals of Intensive Care
#24
MULTICENTER STUDY
Amit Kansal, Shekhar Dhanvijay, Andrew Li, Jason Phua, Matthew Edward Cove, Wei Jun Dan Ong, Ser Hon Puah, Vicky Ng, Qiao Li Tan, Julipie Sumampong Manalansan, Michael Sharey Nocon Zamora, Michael Camba Vidanes, Juliet Tolentino Sahagun, Juvel Taculod, Addy Yong Hui Tan, Chee Kiang Tay, Yew Woon Chia, Duu Wen Sewa, Meiying Chew, Sennen J W Lew, Shirley Goh, Jonathan Jit Ern Tan, Kollengode Ramanathan, Amartya Mukhopadhyay, Kay Choong See
INTRODUCTION: Despite adhering to criteria for extubation, up to 20% of intensive care patients require re-intubation, even with use of post-extubation high-flow nasal cannula (HFNC). This study aims to identify independent predictors and outcomes of extubation failure in patients who failed post-extubation HFNC. METHODS: We conducted a multicentre observational study involving 9 adult intensive care units (ICUs) across 5 public hospitals in Singapore. We included patients extubated to HFNC following spontaneous breathing trials...
June 2021: Annals of the Academy of Medicine, Singapore
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JOURNAL ARTICLE
Jason Tay, Scott Compton, Gillian Phua, Qingyuan Zhuang, Shirlyn Neo, Guozhang Lee, Limin Wijaya, Min Chiam, Natalie Woong, Lalit Krishna
BACKGROUND: The extension of palliative care services to meet the needs of patients with chronic non-malignant life-limiting conditions faces misconceptions amongst healthcare professionals. A study of prevailing perceptions of healthcare professionals on this wider palliative care service was thus conducted to identify current obstacles, guide the education of local healthcare professionals and improve service accessibility. METHODS: A cross-sectional study was carried out at the Singapore General Hospital...
June 30, 2021: BMC Palliative Care
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JOURNAL ARTICLE
Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra
BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice. METHODS: Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the respiratory management of C-ARF in areas where evidence is absent or limited...
March 16, 2021: Critical Care: the Official Journal of the Critical Care Forum
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REVIEW
Yaseen M Arabi, Elie Azoulay, Hasan M Al-Dorzi, Jason Phua, Jorge Salluh, Alexandra Binnie, Carol Hodgson, Derek C Angus, Maurizio Cecconi, Bin Du, Rob Fowler, Charles D Gomersall, Peter Horby, Nicole P Juffermans, Jozef Kesecioglu, Ruth M Kleinpell, Flavia R Machado, Greg S Martin, Geert Meyfroidt, Andrew Rhodes, Kathryn Rowan, Jean-François Timsit, Jean-Louis Vincent, Giuseppe Citerio
Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges, some of which will lead to transformative change. It is obvious to healthcare workers and policymakers alike that an effective critical care surge response must be nested within the overall care delivery model. The COVID-19 pandemic has highlighted key elements of emergency preparedness. These include having national or regional strategic reserves of personal protective equipment, intensive care unit (ICU) devices, consumables and pharmaceuticals, as well as effective supply chains and efficient utilization protocols...
March 2021: Intensive Care Medicine
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JOURNAL ARTICLE
Chi Hung Czarina Leung, Anna Lee, Yaseen M Arabi, Jason Phua, Jigeeshu V Divatia, Younsuck Koh, Bin Du, Cheng Cheng Tan, Jose Emmanuel M Palo, Karen E A Burns, Tae-Hyung Kim, Moritoki Egi, Mohammed Omar Faruq, Babu Raja Shrestha, Shih-Feng Liu, Tuan Dang Nguyen, Bambang Wahjuprajitno, Madiha Hashmi, Boonsong Patjanasoontorn, Zulaidi Latif, Kanishka Indraratna, Hussain N Al Rahma, Seyed Mohammad Reza Hashemian, Charles D Gomersall
RATIONALE: There are limited data on mechanical discontinuation practices in Asia. OBJECTIVES: To document self-reported mechanical discontinuation practices and determine whether there is clinical equipoise regarding protocolized weaning amongst Asian Intensive Care specialists. METHODS: Survey using a validated questionnaire, distributed using a snowball method to Asian Intensive Care specialists. RESULTS: Of 2,967 invited specialists from 20 territories, 2,074 (69...
December 7, 2020: Annals of the American Thoracic Society
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JOURNAL ARTICLE
Zhikang Ye, Bram Rochwerg, Ying Wang, Neill K Adhikari, Srinivas Murthy, François Lamontagne, Robert A Fowler, Haibo Qiu, Li Wei, Ling Sang, Mark Loeb, Ning Shen, Minhua Huang, Zhaonan Jiang, Yaseen M Arabi, Luis Enrique Colunga-Lozano, Li Jiang, Younsuck Koh, Dong Liu, Fang Liu, Jason Phua, Aizong Shen, Tianyi Huo, Bin Du, Suodi Zhai, Gordon H Guyatt
No abstract text is available yet for this article.
October 26, 2020: Canadian Medical Association Journal: CMAJ
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JOURNAL ARTICLE
Jennifer Sumner, Jason Phua, Yee Wei Lim
INTRODUCTION: Novel and efficient healthcare approaches are needed to better serve increasingly older chronic disease patients. Many effective integrated chronic disease management strategies have emerged from the primary care sector. However, in many Asian and developing countries, primary care is underdeveloped, and patients prefer secondary-based services. The Integrated Generalist-led Hospital (IGH) care model is a new approach, which may be better suited for chronic disease patients in the local context...
July 22, 2020: BMJ Open
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JOURNAL ARTICLE
Jason Phua, Madiha Hashmi, Rashan Haniffa
No abstract text is available yet for this article.
August 2020: Intensive Care Medicine
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JOURNAL ARTICLE
Zhikang Ye, Bram Rochwerg, Ying Wang, Neill K Adhikari, Srinivas Murthy, François Lamontagne, Robert A Fowler, Haibo Qiu, Li Wei, Ling Sang, Mark Loeb, Ning Shen, Minhua Huang, Zhaonan Jiang, Yaseen M Arabi, Luis Enrique Colunga-Lozano, Li Jiang, Younsuck Koh, Dong Liu, Fang Liu, Jason Phua, Aizong Shen, Tianyi Huo, Bin Du, Suodi Zhai, Gordon H Guyatt
No abstract text is available yet for this article.
May 19, 2020: Canadian Medical Association Journal: CMAJ
#33
REVIEW
Jason Phua, Li Weng, Lowell Ling, Moritoki Egi, Chae-Man Lim, Jigeeshu Vasishtha Divatia, Babu Raja Shrestha, Yaseen M Arabi, Jensen Ng, Charles D Gomersall, Masaji Nishimura, Younsuck Koh, Bin Du
As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive care unit (ICU) community must prepare for the challenges associated with this pandemic. Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers and other patients who are at risk from nosocomial transmission. Management of acute respiratory failure and haemodynamics is key. ICU practitioners, hospital administrators, governments, and policy makers must prepare for a substantial increase in critical care bed capacity, with a focus not just on infrastructure and supplies, but also on staff management...
May 2020: Lancet Respiratory Medicine
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JOURNAL ARTICLE
Jason Phua
No abstract text is available yet for this article.
March 1, 2020: JAMA Cardiology
#35
JOURNAL ARTICLE
Jason Phua, Mohammad Omar Faruq, Atul P Kulkarni, Ike Sri Redjeki, Khamsay Detleuxay, Naranpurev Mendsaikhan, Kyi Kyi Sann, Babu Raja Shrestha, Madiha Hashmi, Jose Emmanuel M Palo, Rashan Haniffa, Chunting Wang, Seyed Mohammad Reza Hashemian, Aidos Konkayev, Mohd Basri Mat Nor, Boonsong Patjanasoontorn, Khalid Mahmood Khan Nafees, Lowell Ling, Masaji Nishimura, Maher Jaffer Al Bahrani, Yaseen M Arabi, Chae-Man Lim, Wen-Feng Fang
OBJECTIVE: To assess the number of adult critical care beds in Asian countries and regions in relation to population size. DESIGN: Cross-sectional observational study. SETTING: Twenty-three Asian countries and regions, covering 92.1% of the continent's population. PARTICIPANTS: Ten low-income and lower-middle-income economies, five upper-middle-income economies, and eight high-income economies according to the World Bank classification...
May 2020: Critical Care Medicine
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JOURNAL ARTICLE
Andrew Li, Yiong-Huak Chan, Mei Fong Liew, Rakshya Pandey, Jason Phua
Background and objective: Guidelines for chronic obstructive pulmonary disease (COPD) advocate regular influenza vaccination, which has been shown to reduce exacerbations. However, influenza vaccination rates remain low. This quality improvement project was initiated to help improve influenza vaccination rates in a tertiary hospital. Methods: All patients with COPD in the airway program (TAP) in the National University Hospital at the end of 2013 were recruited...
2019: International Journal of Chronic Obstructive Pulmonary Disease
#37
JOURNAL ARTICLE
Kishore R Kumar, Ryan L Davis, Michel C Tchan, G M Wali, Neil Mahant, Karl Ng, Katya Kotschet, Sue-Faye Siow, Jason Gu, Zachary Walls, Ce Kang, Gautam Wali, Stan Levy, Chung Sen Phua, Con Yiannikas, Paul Darveniza, Florence C F Chang, Hugo Morales-Briceño, Dominic B Rowe, Alex Drew, Velimir Gayevskiy, Mark J Cowley, Andre E Minoche, Stephen Tisch, Michael Hayes, Sarah Kummerfeld, Victor S C Fung, Carolyn M Sue
INTRODUCTION: Dystonia is a clinically and genetically heterogeneous disorder and a genetic cause is often difficult to elucidate. This is the first study to use whole genome sequencing (WGS) to investigate dystonia in a large sample of affected individuals. METHODS: WGS was performed on 111 probands with heterogenous dystonia phenotypes. We performed analysis for coding and non-coding variants, copy number variants (CNVs), and structural variants (SVs). We assessed for an association between dystonia and 10 known dystonia risk variants...
December 2019: Parkinsonism & related Disorders
#38
JOURNAL ARTICLE
Shin Yi Ng, Jason Phua, Yu Lin Wong, Ganesh Kalyanasundaram, Amartya Mukhopadhyay, Danny Lim, Naville Chia, Benjamin Choon Heng Ho, Michael J Bailey, Yahya Shehabi, Lian Kah Ti
INTRODUCTION: A study was conducted to describe the sedation practices of intensive care units (ICUs) in Singapore in terms of drug use, sedation depth and the incidence of delirium in both early (< 48 hours) and late (> 48 hours) periods of ICU admission. METHODS: A prospective multicentre cohort study was conducted on patients who were expected to be sedated and ventilated for over 24 hours in seven ICUs (surgical ICU, n = 4; medical ICU, n = 3) of four major public hospitals in Singapore...
January 2020: Singapore Medical Journal
#39
JOURNAL ARTICLE
Tomohisa Furuya, Jun H Phua, Mark Ruschin, Hiroshi Tanaka, Keiji Nihei, Dilini Pinnaduwage, Yu Kumazaki, Masao Nakayama, Hideki Nishimura, Jason St-Hilaire, Isabelle Thibault, Daniel T Yat Harn, Lijun Ma, Naoto Shikama, Arjun Sahgal, Katsuyuki Karasawa
PURPOSE: This study aimed to assess the effectiveness of multiple dose-volume specifications in minimizing interinstitutional, target-prescribed, dose variations for spine stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Seven institutions with a total of 10 treatment apparatuses participated in this study. SBRT plans for 3 representative spinal metastases were generated using 2 different protocols (Protocols 1 and 2) for target dose. While using just 2 target dose objectives (doses delivered to 95% and maximum point dose) in Protocol 1, 3 target dose constraints (doses delivered to 95% and 50% and maximum point dose) were defined in Protocol 2 with the intent to decrease target dose variation...
January 2019: Practical Radiation Oncology
#40
JOURNAL ARTICLE
Kay Choong See, Ming Yan Zhao, Emiko Nakataki, Kaweesak Chittawatanarat, Wen-Feng Fang, Mohammad Omar Faruq, Bambang Wahjuprajitno, Yaseen M Arabi, Wai Tat Wong, Jigeeshu V Divatia, Jose Emmanuel Palo, Babu Raja Shrestha, Khalid M K Nafees, Nguyen Gia Binh, Hussain Nasser Al Rahma, Khamsay Detleuxay, Venetia Ong, Jason Phua
PURPOSE: Professional burnout is a multidimensional syndrome comprising emotional exhaustion, depersonalization, and diminished sense of personal accomplishment, and is associated with poor staff health and decreased quality of medical care. We investigated burnout prevalence and its associated risk factors among Asian intensive care unit (ICU) physicians and nurses. METHODS: We conducted a cross-sectional survey of 159 ICUs in 16 Asian countries and regions. The main outcome measure was burnout as assessed by the Maslach Burnout Inventory-Human Services Survey...
December 2018: Intensive Care Medicine
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