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Sjogrens Syndrome

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https://www.readbyqxmd.com/read/28330998/comparison-of-performance-of-the-2016-acr-eular-classification-criteria-for-primary-sj%C3%A3-gren-s-syndrome-with-other-sets-of-criteria-in-japanese-patients
#1
Hiroto Tsuboi, Shinya Hagiwara, Hiromitsu Asashima, Hiroyuki Takahashi, Tomoya Hirota, Hisashi Noma, Hisanori Umehara, Atsushi Kawakami, Hideki Nakamura, Hajime Sano, Kazuo Tsubota, Yoko Ogawa, Etsuko Takamura, Ichiro Saito, Hiroko Inoue, Seiji Nakamura, Masafumi Moriyama, Tsutomu Takeuchi, Yoshiya Tanaka, Shintaro Hirata, Tsuneyo Mimori, Isao Matsumoto, Takayuki Sumida
OBJECTIVES: To compare the performance of the new 2016 American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria for primary Sjögren's syndrome (SS) with 1999 revised Japanese Ministry of Health criteria for diagnosis of SS (JPN), 2002 American-European Consensus Group classification criteria for SS (AECG) and 2012 ACR classification criteria for SS (ACR) in Japanese patients. METHODS: The study subjects were 499 patients with primary SS (pSS) or suspected pSS who were followed up in June 2012 at 10 hospitals in Japan...
March 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28330683/insight-into-pathogenesis-of-sj%C3%A3-gren-s-syndrome-dissection-on-autoimmune-infiltrates-and-epithelial-cells
#2
Andreas V Goules, Efstathia K Kapsogeorgou, Athanasios G Tzioufas
Sjögren's syndrome (SS) is a chronic autoimmune disease with broad clinical spectrum, extending from benign exocrinopathy to severe systemic disease and lymphoma development. The glandular and extraglandular dysfunction of SS is associated with lymphocytic infiltrates that invade the epithelial structures of affected organs. The in-depth study of autoimmune lesions in the minor salivary glands (MSG), which are the major target-organ of SS responses, revealed that the lymphocytic infiltrates vary in severity and composition among SS-patients, are full-blown at diagnosis and remain unchanged thereafter...
March 19, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28326738/-dental-implantation-in-a-patient-with-sj%C3%A3-gren-s-syndrome-a-case-report
#3
Luo Cuifen, Peng Guoguang, Feng Yuanhua, Huang Xingxiang
We reported one case of a patient with Sjögren's syndrome and dental implant. This patient was followed up for more than one year. The patient was diagnosed with Sjögren's syndrome for 5 years and treated with long-term corticosteroid. Four implant-tissue interface hydrophilic implants were placed on 15, 16, 44, and 46 of the mandibular and maxillary areas. After the surgery was completed, the patient was treated with oral antibiotic and "shenggu pills" to prevent infection and glucocorticoid to manage Sjögren's syndrome...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326325/a-potential-of-sfasl-in-preventing-gland-injury-in-sjogren-s-syndrome
#4
Jiao Luo, Ying Wang, Bing Yu, Hongyan Qian, Yan He, Guixiu Shi
Fas and its ligand FasL, members of tumor necrosis factor receptor superfamily, have been implicated in the process of cell apoptosis. FasL consists of two forms, membrane FasL (mFasL) and soluble FasL (sFasL). sFasL can be produced by mFasL cleaved by matrix metalloproteinases (MMP) and also reveals a role for binding to Fas which is expressed on cell surface. Although Fas/FasL axis has been implicated in a variety of diseases, its role in Sjogren's syndrome still remains ill defined. In this study, we investigated the potential of sFasL in the pathogenesis of Sjogren's syndrome (SS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28324200/prevalence-and-characterization-of-non-sicca-onset-primary-sj%C3%A3-gren-syndrome-with-interstitial-lung-involvement
#5
Manfredi Andreina, Sebastiani Marco, Cerri Stefania, Cassone Giulia, Bellini Pietrantonio, Della Casa Giovanni, Luppi Fabrizio, Ferri Clodoveo
Primary Sjögren syndrome (pSS)-related interstitial lung disease (ILD) involved about 10-20% of patients. In 20% of cases, ILD can be diagnosed before pSS; anyway, few studies have investigated the frequency of ILD as the first clinically relevant manifestation of pSS, generally referred to retrospective studies. Aim of our prospective study was to describe prevalence, clinical, serological, and instrumental features of non-sicca onset pSS patients with interstitial lung involvement. During a period of 48 months, all consecutive patients diagnosed as pSS were enrolled...
March 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28323371/diffusional-kurtosis-imaging-of-parotid-glands-in-sj%C3%A3-gren-s-syndrome-initial-findings
#6
Chen Chu, Huayong Zhang, Nan Zhou, Xin Dou, Ming Li, Song Liu, Yun Zhu, Chun Wang, Weibo Chen, Queenie Chan, Lingyun Sun, Jian He, Zhengyang Zhou
PURPOSE: To explore the role of diffusion kurtosis imaging (DKI) of parotid glands in diagnosing Sjögren's syndrome (SS). MATERIALS AND METHODS: A total of 40 patients with SS and 40 healthy volunteers underwent 3.0T magnetic resonance imaging (MRI) including DKI, which generated the apparent diffusion coefficient (ADC), corrected diffusion (D), and diffusional kurtosis (K) values. The MR nodular grade was determined on the basis of MR morphological findings. RESULTS: The parotid ADC, D, and K values in patients with SS were significantly higher than those of healthy volunteers (P = 0...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28321568/gastrointestinal-and-liver-lesions-in-primary-childhood-sj%C3%A3-gren-syndrome
#7
Yasuyo Kashiwagi, Tatsuro Hatsushika, Norito Tsutsumi, Soken Go, Shigeo Nishimata, Hisashi Kawashima
Sjögren syndrome (SS) is characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands, leading to keratoconjunctivitis sicca and xerostomia. SS is one of the most common autoimmune rheumatic diseases in adults; however, few cases of primary childhood SS with gastrointestinal and liver lesions have been reported in the literature. We report five cases of primary childhood SS with gastrointestinal and liver lesions. Multiple gastric biopsies in four cases revealed atrophic gastritis in the antrum of the stomach or chronic gastritis...
March 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28315833/predictive-factors-for-the-placebo-effect-in-clinical-trials-for-dry-eye-a-pooled-analysis-of-three-clinical-trials
#8
Takahiro Imanaka, Izumi Sato, Shiro Tanaka, Koji Kawakami
BACKGROUND: Placebo effect is one of the methodological difficulties in dry eye clinical trials. If we could elucidate the tendencies of the placebo response and find predictors, we could reduce the placebo response in clinical trials for dry eye. In this study, we investigated the predictive factors for the placebo effect in dry eye clinical trials. METHODS: A total of 205 patients with dry eye assigned to the placebo arms of three placebo-controlled randomised clinical trials were analysed by simple and multivariable regression analysis...
March 18, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28314382/erratum-to-a-randomized-double-blind-placebo-controlled-clinical-trial-of-fluoride-varnish-in-preventing-dental-caries-of-sj%C3%A3-gren-s-syndrome-patients
#9
Weini Xin, Katherine Chiu Man Leung, Edward Chin Man Lo, Mo Yin Mok, Moon Ho Leung
No abstract text is available yet for this article.
March 17, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28301413/ophthalmic-findings-in-late-stage-sjogren-larsson-syndrome
#10
Tavish Nanda, Jaclyn L Kovach
PURPOSE: To report spectral domain optical coherence tomography and fundus autofluorescence documentation of late stage macular findings associated with Sjogren-Larsson Syndrome in three adult siblings. METHODS: Three adult siblings with Sjogren-Larsson Syndrome underwent ophthalmic examination and imaging. RESULTS: Crystalline maculopathy and subretinal deposits, presumably lipofuscin accumulation, with macular atrophy were present in varying degrees in all three adult siblings...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28300881/frontal-fibrosing-alopecia-in-association-with-sj%C3%A3-gren-s-syndrome-more-than-a-simple-coincidence
#11
Karina Colossi Furlan, Priscila Kakizaki, Juliana Cabral Nunes Chartuni, Neusa Yuriko Sakai Valente
Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28298559/the-risk-of-deep-venous-thrombosis-and-pulmonary-embolism-in-primary-sj%C3%A3-gren-syndrome-a-general-population-based-study
#12
J Antonio Aviña-Zubieta, Michael Jansz, Eric C Sayre, Hyon K Choi
OBJECTIVE: To estimate the future risk and time trends of venous thromboembolism (VTE) in individuals with newly diagnosed primary Sjögren syndrome (pSS) in the general population. METHODS: Using a population database that includes all residents of British Columbia, Canada, we created a study cohort of all patients with incident SS and up to 10 controls from the general population matched for age, sex, and entry time. We compared incidence rates (IR) of pulmonary embolism (PE), deep vein thrombosis (DVT), and VTE between the 2 groups according to SS disease duration...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28296257/randomized-controlled-trial-of-rituximab-and-cost-effectiveness-analysis-in-treating-fatigue-and-oral-dryness-in-primary-sjogren-s-syndrome
#13
Simon J Bowman, Colin C Everett, John L O'Dwyer, Paul Emery, Costantino Pitzalis, Wan-Fai Ng, Colin T Pease, Elizabeth J Price, Nurhan Sutcliffe, Nagui St Gendi, Frances C Hall, Sharon P Ruddock, Catherine Fernandez, Catherine Reynolds, Claire T Hulme, Kevin A Davies, Christopher J Edwards, Peter C Lanyon, Robert J Moots, Euthalia Roussou, Ian P Giles, Linda D Sharples, Michele Bombardieri
OBJECTIVE: We investigated whether rituximab, an anti-B-cell therapy, improved symptoms of fatigue and oral dryness in patients with Primary Sjögren's Syndrome (PSS). METHODS: Multicentre, randomised, double-blind, parallel-group placebo-controlled trial, including Health Economic Analysis. Anti-Ro positive patients with PSS, symptomatic fatigue and oral dryness were recruited from 25 UK rheumatology clinics from August 2011 to January 2014. Patients were centrally-randomised to either placebo IV or rituximab IV (1000mg in 250mL) at weeks 0, 2, 24 and 26, with pre-and post-infusion medication including corticosteroids...
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28296253/rituximab-in-the-treatment-of-sj%C3%A3-gren-s-syndrome-is-it-the-wrong-drug
#14
EDITORIAL
Hendrika Bootsma, Frans G M Kroese, Arjan Vissink
No abstract text is available yet for this article.
March 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28292174/extrahepatic-manifestations-of-primary-biliary-cholangitis
#15
REVIEW
Sara L Chalifoux, Peter G Konyn, Gina Choi, Sammy Saab
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis. PBC is known to have both hepatic and extrahepatic manifestations. Extrahepatic manifestations are seen in up to 73% of patients with PBC, with the most common being Sjogren's syndrome, thyroid dysfunction and systemic sclerosis. It is thought that patients with PBC are at increased risk of developing these extrahepatic manifestations, almost all of which are autoimmune, because patients with autoimmune disease are at higher risk of developing another autoimmune condition...
March 16, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28289872/criteria-sets-for-primary-sjogren-s-syndrome-are-not-adequate-for-those-presenting-with-extraglandular-organ-involvements-as-their-dominant-clinical-features
#16
Yasemin Kabasakal, Gul Kitapçıoğlu, Gonca Karabulut, Mehmet Tezcan, Ayse Balkarlı, Adem Aksoy, Şule Yavuz, Sema Yılmaz, Timuçin Kaşifoğlu, Umut Kalyoncu, Ediz Dalkılıç, Abdurrahman Tufan, Rıdvan Mercan, Fatih Yıldız, Taşkın Şentürk, Fatoş Önen, Cemal Bes, Eren Erken, Ercan Tunç, Sevil Kamalı, Emine Tarhan, Ayten Yazıcı, Nurşen Düzgün, Müge Bıçakçıgil, Sedat Yılmaz, Mustafa Özmen, Lale Öcal, Fatma Alibaz-Öner, Dilek Solmaz, Veli Çobankara, Selim Nalbant, Esen Kasapoğlu Günal, Derya Kaşkari, Berna Göker
Patients with primary Sjogren's syndrome (pSS) may go undiagnosed or be misclassified due to the insidious nature and wide spectrum of the disease. The available several classification criteria emphasize glandular findings. We aimed to analyze the efficiency of various classification criteria sets in patients diagnosed on the clinical basis by expert opinion and to compare those pSS patients who fulfilled these criteria with those who did not. This is a multicenter study in which 834 patients from 22 university-based rheumatology clinics are included...
March 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28288723/clinical-features-and-management-of-non-gastrointestinal-non-ocular-extranodal-mucosa-associated-lymphoid-tissue-enmalt-marginal-zone-lymphomas
#17
REVIEW
Estella Matutes, Carlos Montalban
Extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas may arise at any site of the body. The most frequent localizations other than gastrointestinal and eye are salivary gland, skin, lung and thyroid. These lymphomas usually arise in a setting of inflammation due to a persistent infection or autoimmune diseases such as Sjogren syndrome in salivary MALT lymphomas and Hashimoto's thryroiditis in thyroid lymphomas. They affect middle-aged patients with a female predominance when lymphoma arises in certain locations...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28288719/marginal-zone-lymphoma-associated-autoimmunity-and-auto-immune-disorders
#18
REVIEW
Larissa Sena Teixeira Mendes, Andrew Wotherspoon
Large epidemiological studies have shown a consistent increased risk for developing lymphoma in the setting of autoimmune disorders (AID). It is known that this link appears to be stronger for some AID and certain non-Hodgkin lymphoma subtypes e.g. Sjögren's syndrome and extra-nodal marginal zone lymphoma of the salivary gland, and thyroid MALT lymphoma in a background of Hashimoto's thyroiditis. B and T-cell hyperactivity due to chronic antigenic stimulation and the consequent presence of acquired lymphoid tissue seems to play a key role in the pathogenesis of AI-related lymphomas...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28284773/extranodal-marginal-zone-b-cell-lymphoma-an-unexpected-complication-in-children-with-sj%C3%A3-gren-s-syndrome
#19
Paz Collado, Aml Kelada, Maria Cámara, Andrew Zeft, Aron Flagg
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by the infiltration of lymphocytes into exocrine glands, resulting in the typical sicca symptoms. Unlike adults, primary SS is a very rare condition in childhood, and the risk of malignancy in juvenile SS (JSS) has not been defined. We report the detection of extranodal marginal zone B-cell lymphoma (EMZL) occurring in two children with SS. Fine needle aspiration of the salivary glands (SG) showed nonspecific findings that led to delayed diagnosis of SS...
March 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28284305/autodisplay-of-the-la-ssb-protein-on-lps-free-e-coli-for-the-diagnosis-of-sj%C3%A3-gren-s-syndrome
#20
Gu Yoo, Carina Dilkaute, Ji-Hong Bong, Hyun-Woo Song, Misu Lee, Min-Jung Kang, Joachim Jose, Jae-Chul Pyun
The objective of this study was to present an immunoassay for the diagnosis of Sjögren's syndrome based on the autodisplayed La/SSB protein on the outer membrane of intact E. coli (strain UT-5600) and LPS-free E. coli (ClearColi™). As the first step, an autodisplay vector (pCK002) was transfected into intact E. coli and LPS-free E. coli for comparison of efficiency of autdisplay of La/SSB. The maximal level of La/SSB expression was estimated to be similar for LPS-free E. coli and intact E. coli at different optimal induction periods...
May 2017: Enzyme and Microbial Technology
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