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https://www.readbyqxmd.com/read/29036922/microrna-and-mrna-dysregulation-in-astrocytes-infected-with-zika-virus
#1
Robert A Kozak, Anna Majer, Mia J Biondi, Sarah J Medina, Lee W Goneau, Babu V Sajesh, Jessy A Slota, Vanessa Zubach, Alberto Severini, David Safronetz, Shannon L Hiebert, Daniel R Beniac, Timothy F Booth, Stephanie A Booth, Gary P Kobinger
The Zika virus (ZIKV) epidemic is an ongoing public health concern. ZIKV is a flavivirus reported to be associated with microcephaly, and recent work in animal models demonstrates the ability of the virus to cross the placenta and affect fetal brain development. Recent findings suggest that the virus preferentially infects neural stem cells and thereby deregulates gene expression, cell cycle progression, and increases cell death. However, neuronal stem cells are not the only brain cells that are susceptible to ZIKV and infection of other brain cells may contribute to disease progression...
October 14, 2017: Viruses
https://www.readbyqxmd.com/read/29028528/inhibitors-of-yellow-fever-virus-replication-based-on-1-3-5-triphenyl-4-5-dihydropyrazole-scaffold-design-synthesis-and-antiviral-evaluation
#2
Rossella Fioravanti, Nicoletta Desideri, Antonio Carta, Elena Maria Atzori, Ilenia Delogu, Gabriella Collu, Roberta Loddo
By the antiviral screening of an in house library of pyrazoline compounds, 4-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide (5a) was identified as a promising hit compound for the development of anti- Yellow Fever Virus (YFV) agents. Structural optimization studies were focused on the development of 5a analogues which retain the potency as YFV inhibitors and show a reduced cytotoxicity. The synthesized 1-3,5-triphenyl-pyrazolines (4a-j, 5a-j, 6a-j) were evaluated in cell based assays for cytotoxicity and antiviral activity against representative viruses of two of the three genera of the Flaviviridae family, i...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29022864/reverse-genetic-system-genetically-stable-reporter-viruses-and-packaged-subgenomic-replicon-based-on-a-brazilian-zika-virus-isolate
#3
Margit Mutso, Sirle Saul, Kai Rausalu, Olga Susova, Eva Žusinaite, Suresh Mahalingam, Andres Merits
Zika virus (ZIKV, genus Flavivirus) has emerged as a major mosquito-transmitted human pathogen, with recent outbreaks associated with an increased incidence of neurological complications, particularly microcephaly and the Guillain-Barré syndrome. Because the virus has only very recently emerged as an important pathogen, research is being hampered by a lack of reliable molecular tools. Here we report an infectious cDNA (icDNA) clone for ZIKV isolate BeH819015 from Brazil, which was selected as representative of South American ZIKV isolated at early stages of the outbreak...
October 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29020245/guillain-barr%C3%A3-syndrome-associated-with-zika-virus-infection-in-martinique-in-2016-a-prospective-study
#4
Benoît Rozé, Fatiha Najioullah, Jean-Louis Fergé, Frédérique Dorléans, Kossivi Apetse, Jose-Luis Barnay, Elise Daudens-Vaysse, Yannick Brouste, Raymond Césaire, Laurence Fagour, Ruddy Valentino, Martine Ledrans, Hossein Mehdaoui, Sylvie Abel, Isabelle Leparc-Goffart, Aissatou Signate, André Cabié
Background: Guillain-Barré syndrome (GBS) has been reported to be associated with Zika virus (ZIKV) infection in case reports and retrospective studies, mostly on the basis of serological tests, with the problematic cross-reacting antibodies of the Flavivirus genus. Some GBS cases do not exhibit a high level of diagnostic certainty. This prospective study aimed to describe the clinical profiles and the frequency of GBS associated with ZIKV during the ZIKV outbreak in Martinique in 2016...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020227/rapid-detection-of-powassan-virus-in-a-patient-with-encephalitis-by-metagenomic-sequencing
#5
Anne Piantadosi, Sanjat Kanjilal, Vijay Ganesh, Arjun Khanna, Emily P Hyle, Jonathan Rosand, Tyler Bold, Hayden C Metsky, Jacob Lemieux, Michael J Leone, Lisa Freimark, Christian B Matranga, Gordon Adams, Graham McGrath, Siavash Zamirpour, Sam Telford, Eric Rosenberg, Tracey Cho, Matthew P Frosch, Marcia B Goldberg, Shibani S Mukerji, Pardis C Sabeti
We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.
September 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020226/innate-t-and-b-cell-responses-in-acute-human-zika-patients
#6
Lilin Lai, Nadine Rouphael, Yongxian Xu, Muktha S Natrajan, Allison Beck, Mari Hart, Matthew Feldhammer, Amanda Feldpausch, Charles Hill, Henry Wu, Jessica K Fairley, Pamela Lankford-Turner, Nicole Kasher, Patrick Rago, Yi-Juan Hu, Srilatha Edupuganti, Shital M Patel, Kristy O Murray, Mark J Mulligan
Background: There is an urgent need for studies of viral persistence and immunity during human Zika infections to inform planning and conduct of vaccine clinical trials. Methods: In five returned US travelers with acute symptomatic Zika infection, clinical features, viral RNA levels, and immune responses were characterized. Results: Two pregnant, flavivirus-experienced patients had viral RNA persist in plasma for >44 and >26 days. Three days after symptom onset transient increases in pro-inflammatory monocytes began followed at five days by transient decreases in myeloid dendritic cells...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018589/neurological-complications-in-a-polynesian-traveler-with-dengue
#7
Maegan Lm Doi, Sydney Y Tatsuno, Gurdev Singh, Eric M Tatsuno, Marjorie M Mau
In recent times, there has been an increased focus on mosquito-borne Flaviviruses, in particular dengue and Zika. With the reappearance of dengue in Hawai'i and the mainland United States (US), clinicians should be aware of both the common presentations of dengue, as well as other less common complications associated with the disease. Dengue can result in neurologic disorders such as encephalopathy, encephalitis, immune-mediated syndromes, neuromuscular dysfunction, and neuro-ophthalmologic disorders. We present an interesting case of dengue that initially presented with classic symptoms (arthropathy, biphasic fever, and rash) and subsequently developed into a neurologic movement disorder with muscle tightening and twitching of the face, chest, and extremities...
October 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29018252/neutralization-of-zika-virus-by-germline-like-human-monoclonal-antibodies-targeting-cryptic-epitopes-on-envelope-domain-iii
#8
Yanling Wu, Shun Li, Lanying Du, Chunyu Wang, Peng Zou, Binbin Hong, Mengjiao Yuan, Xiaonan Ren, Wanbo Tai, Yu Kong, Chen Zhou, Lu Lu, Xiaohui Zhou, Shibo Jiang, Tianlei Ying
The Zika virus (ZIKV), a flavivirus transmitted by Aedes mosquitoes, has emerged as a global public health concern. Pre-existing cross-reactive antibodies against other flaviviruses could modulate immune responses to ZIKV infection by antibody-dependent enhancement, highlighting the importance of understanding the immunogenicity of the ZIKV envelope protein. In this study, we identified a panel of human monoclonal antibodies (mAbs) that target domain III (DIII) of the ZIKV envelope protein from a very large phage-display naive antibody library...
October 11, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29017720/insights-into-the-molecular-roles-of-zika-virus-in-human-reproductive-complications-and-congenital-neuropathologies
#9
REVIEW
Rajendra Gharbaran, Latchman Somenarain
The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor cells (NPCs) of the developing fetus, resulting in changes of brain structures, reminiscent of human microcephaly. In vitro and ex vivo studies using human cells and tissues showed that human NPCs and placental cells are targeted by ZIKV...
October 7, 2017: Pathology
https://www.readbyqxmd.com/read/29016330/characterization-of-three-new-insect-specific-flaviviruses-their-relationship-to-the-mosquito-borne-flavivirus-pathogens
#10
Hilda Guzman, Maria Angelica Contreras-Gutierrez, Amelia P A Travassos da Rosa, Marcio R T Nunes, Jedson F Cardoso, Vsevolod L Popov, Katherine I Young, Chelsea Savit, Thomas G Wood, Steven G Widen, Douglas M Watts, Kathryn A Hanley, David Perera, Durland Fish, Nikos Vasilakis, Robert B Tesh
Three novel insect-specific flaviviruses, isolated from mosquitoes collected in Peru, Malaysia (Sarawak), and the United States, are characterized. The new viruses, designated La Tina, Kampung Karu, and Long Pine Key, respectively, are antigenically and phylogenetically more similar to the mosquito-borne flavivirus pathogens, than to the classical insect-specific viruses like cell fusing agent and Culex flavivirus. The potential implications of this relationship and the possible uses of these and other arbovirus-related insect-specific flaviviruses are reviewed...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016323/enzootic-circulation-of-chikungunya-virus-in-east-africa-serological-evidence-in-nonhuman-kenyan-primates
#11
Gillian Eastwood, Rosemary C Sang, Matilde Guerbois, Evans L N Taracha, Scott C Weaver
Chikungunya virus (CHIKV) is a globally emerging pathogen causing debilitating arthralgia and fever in humans. First identified in Tanzania (1953), this mosquito-borne alphavirus received little further attention until a 2004 re-emergence in Kenya from an unknown source. This outbreak subsequently spread to the Indian Ocean, with adaptation for transmission by a new urban vector. Under the hypothesis that sylvatic progenitor cycles of CHIKV exist in Kenya (as reported in West Africa, between nonhuman primates (NHPs) and arboreal Aedes spp...
September 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28991697/zika-virus-disease-associated-guillain-barr%C3%A3-syndrome-barranquilla-colombia-2015-2016
#12
Jorge L Salinas, Diana M Walteros, Ashley Styczynski, Flavio Garzón, Hernán Quijada, Elsa Bravo, Pablo Chaparro, Javier Madero, Jorge Acosta-Reyes, Jeremy Ledermann, Zuleima Arteta, Erin Borland, Paul Burns, Maritza Gonzalez, Ann M Powers, Marcela Mercado, Alma Solano, James J Sejvar, Martha L Ospina
BACKGROUND: An outbreak of Guillain-Barré syndrome (GBS), a disorder characterized by acute, symmetric limb weakness with decreased or absent deep-tendon reflexes, was reported in Barranquilla, Colombia, after the introduction of Zika virus in 2015. We reviewed clinical data for GBS cases in Barranquilla and performed a case-control investigation to assess the association of suspect and probable Zika virus disease with GBS. METHODS: We used the Brighton Collaboration Criteria to confirm reported GBS patients in Barranquilla during October 2015-April 2016...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28986825/epidemiological-surveillance-of-viral-hemorrhagic-fevers-with-emphasis-on-clinical-virology
#13
Carolina Montoya-Ruiz, Juan David Rodas
This article will outline surveillance approaches for viral hemorrhagic fevers. Specific methods for surveillance of clinical samples will be emphasized. Separate articles will describe methods for surveillance of rodent-borne viruses (roboviruses) and arthropod-borne viruses (arboviruses). Since the appearance of hantaviruses and arenaviruses in the Americas, more than 30 different species in each group have been established, and therefore they have become the most frequently emerging viruses. Flaviviruses such as yellow fever and dengue viruses, although easier to recognize, are also more widely spread and therefore considered a very important public health issue, particularly for under-developed countries...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28985612/a-dual-marker-label-free-electrochemical-assay-for-flavivirus-dengue-diagnosis
#14
Adriano Santos, Paulo R Bueno, Jason J Davis
Dengue is a RNA viral illness of the genus Flavivirus which can cause, depending on the pervasiveness of the infection, hemorrhagic dengue fever or dengue shock syndrome. Herein we present an electrochemical label free approach enabling the rapid sensitive quantification of NS1 and IgG (supporting an ability to distinguish primary and secondary infections). Using a bifunctional SAM containing PEG moieties and a tethered redox thiol, both markers are detectable across clinically relevant levels by label free impedance derived redox capacitance...
September 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28985234/pathogenesis-and-sexual-transmission-of-spondweni-and-zika-viruses
#15
Erin M McDonald, Nisha K Duggal, Aaron C Brault
The Spondweni serogroup of viruses (Flaviviridae, Flavivirus) is comprised of Spondweni virus (SPONV) and Zika virus (ZIKV), which are mosquito-borne viruses capable of eliciting human disease. Numerous cases of ZIKV sexual transmission in humans have been documented following the emergence of the Asian genotype in the Americas. The African ZIKV genotype virus was previously implicated in the first reported case of ZIKV sexual transmission. Reports of SPONV infection in humans have been associated with non-specific febrile illness, but no association with sexual transmission has been reported...
October 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28980717/development-and-evaluation-of-one-step-multiplex-real-time-rt-pcr-assay-for-simultaneous-detection-of-zika-virus-and-chikungunya-virus
#16
Si-Qing Liu, Xiao Li, Cheng-Lin Deng, Zhi-Ming Yuan, Bo Zhang
Zika virus (ZIKV) and chikungunya virus (CHIKV) are important human pathogens and mosquito-borne arboviruses, which have resembling history, common vectors, circulating regions, and indistinguishable clinical symptoms. Wide geographical range that is suitable for ZIKV and CHIKV transmission underlines the concern about the impact of epidemic and endemic infections on burden of public health. In the present study, a highly sensitive and specific one-step multiplex real-time RT-PCR assay was developed and evaluated for simultaneous detection and quantification of ZIKV and CHIKV...
October 5, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28972551/sophoraflavenone-g-restricts-dengue-and-zika-virus-infection-via-rna-polymerase-interference
#17
Alexandre Sze, David Olagnier, Samar Bel Hadj, Xiaoying Han, Xiao Hong Tian, Hong-Tao Xu, Long Yang, Qingwen Shi, Penghua Wang, Mark A Wainberg, Jian Hui Wu, Rongtuan Lin
Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition...
October 3, 2017: Viruses
https://www.readbyqxmd.com/read/28969658/characterization-and-epitope-mapping-of-dengue-virus-type-1-specific-monoclonal-antibodies
#18
Wen-Hung Chen, Feng-Pai Chou, Yu-Kuo Wang, Sheng-Cih Huang, Chuan-Hung Cheng, Tung-Kung Wu
BACKGROUND: Dengue virus (DV) infection causes a spectrum of clinical diseases ranging from dengue fever to a life-threatening dengue hemorrhagic fever. Four distinct serotypes (DV1-4), which have similar genome sequences and envelope protein (E protein) antigenic properties, were divided. Among these 4 serotypes, DV1 usually causes predominant infections and fast diagnosis and effective treatments are urgently required to prevent further hospitalization and casualties. METHODS: To develop antibodies specifically targeting and neutralizing DV1, we immunized mice with UV-inactivated DV1 viral particles and recombinant DV1 E protein from residue 1 to 395 (E395), and then generated 12 anti-E monoclonal antibodies (mAbs) as the candidates for a series of characterized assays such as ELISA, dot blot, immunofluorescence assay, western blot, and foci forming analyses...
October 2, 2017: Virology Journal
https://www.readbyqxmd.com/read/28968905/yellow-fever-virus-but-not-zika-or-dengue-virus-inhibits-t-cell-receptor-mediated-t-cell-function-by-an-rna-based-mechanism
#19
James H McLinden, Nirjal Bhattarai, Jack T Stapleton, Qing Chang, Thomas M Kaufman, Suzanne L Cassel, Fayyaz S Sutterwala, Hillel Haim, Jon Houtman, Jinhua Xiang
The Flavivirus genus within the Flaviviridae is comprised of many important human pathogens including Yellow Fever virus (YFV), Dengue virus (DENV) and Zika virus (ZKV), all of which are global public health concerns. Although the related flaviviruses hepatitis C virus and human pegivirus (formerly named GBV-C) interfere with T cell receptor (TCR) signaling by novel RNA and protein based mechanisms, the effect of other flaviviruses on TCR signaling is unknown. Here, we studied the effect of YFV, DENV, and ZKV on TCR signaling...
September 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968863/replication-of-zika-virus-in-human-prostate-cells-a-potential-source-of-sexually-transmitted-virus
#20
Jennifer L Spencer, Anismrita Lahon, Linda L Tran, Ravi P Arya, Alexander R Kneubehl, Megan B Vogt, Daniela Xavier, David R Rowley, Jason T Kimata, Rebecca R Rico-Hesse
Background: While Zika virus (ZIKV) is mainly transmitted by mosquitoes, numerous cases of sexual transmission have been reported during recent outbreaks. Little is known about which host cell types or entry factors aid in mediating this sexual transmission. Methods: In this study, we investigated ZIKV cell tropism by infecting two types of human prostate cells with three contemporary ZIKV isolates from persons infected in the Americas. We utilized qRT-PCR and immunofluorescence to measure infection and flow cytometry to detect entry factor expression...
August 24, 2017: Journal of Infectious Diseases
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