Eric Leblanc, Fabrice Narducci, Gwenaël Ferron, Audrey Mailliez, Jean-Yves Charvolin, Houssein El Hajj, Frédéric Guyon, Virginie Fourchotte, Eric Lambaudie, Agathe Crouzet, Yves Fouche, Sébastien Gouy, Pierre Collinet, Frédéric Caquant, Christophe Pomel, François Golfier, Véronique Vaini-Cowen, Isabelle Fournier, Michel Salzet, Emmanuelle Tresch, Alicia Probst, Anne-Sophie Lemaire, Marie-Cécile Le Deley, Delphine Hudry
Risk-reducing salpingo-oophorectomy is the gold standard for the prophylaxis of ovarian cancer in high-risk women. Due to significant adverse effects, 20-30% of women delay or refuse early oophorectomy. This prospective pilot study (NCT01608074) aimed to assess the efficacy of radical fimbriectomy followed by a delayed oophorectomy in preventing ovarian and pelvic invasive cancer (the primary endpoint) and to evaluate the safety of both procedures. The key eligibility criteria were pre-menopausal women ≥35 years with a high risk of ovarian cancer who refused a risk-reducing salpingo-oophorectomy...
February 10, 2023: Cancers