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prophylactic oophorectomy

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https://www.readbyqxmd.com/read/27873046/commercially-available-lifestyle-modification-program-randomized-controlled-trial-addressing-heart-and-bone-health-in-brca1-2-breast-cancer-survivors-after-risk-reducing-salpingo-oophorectomy
#1
Kathleen M Sturgeon, Lorraine T Dean, Mariane Heroux, Jessica Kane, Toni Bauer, Erica Palmer, Jin Long, Shannon Lynch, Linda Jacobs, David B Sarwer, Mary B Leonard, Kathryn Schmitz
PURPOSE: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. METHODS: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed...
November 21, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27737975/identification-and-management-of-women-with-a-family-history-of-breast-cancer-practical-guide-for-clinicians
#2
Ruth Heisey, June C Carroll
OBJECTIVE: To summarize the best evidence on strategies to identify and manage women with a family history of breast cancer. SOURCES OF INFORMATION: A PubMed search was conducted using the search terms breast cancer, guidelines, risk, family history, management, and magnetic resonance imaging screening from 2000 to 2016. Most evidence is level II. MAIN MESSAGE: Taking a good family history is essential when assessing breast cancer risk in order to identify women suitable for referral to a genetic counselor for possible genetic testing...
October 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27649974/risk-reduction-and-survival-benefit-of-prophylactic-surgery-in-brca-mutation-carriers-a-systematic-review
#3
Kandice K Ludwig, Joan Neuner, Annabelle Butler, Jennifer L Geurts, Amanda L Kong
BACKGROUND: Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may be faced with questions about surgical risk reduction and survival benefit of prophylactic surgery. METHODS: A systematic literature review was performed using the electronic databases PubMed, OVID MEDLINE, and Scopus comparing prophylactic surgery vs observation with respect to breast and ovarian cancer risk reduction and mortality in BRCA mutation carriers...
October 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27623744/the-impact-of-an-expanded-genetic-testing-program-and-selective-oophorectomy-on-the-incidence-of-ovarian-cancer-in-west-pomerania
#4
J Menkiszak, V Sopik, A Chudecka-Głaz, W Domagała, E Urasińska, H Symonowicz, E Majdanik, P Waloszczyk, K Sycz, M Świniarska, T Huzarski, C Cybulski, T Debniak, O Oszurek, J Lubinski, S A Narod, J Gronwald
The aim of the study was to evaluate the impact of a regional population-based genetic testing program on the incidence of ovarian cancer in West Pomerania. Between 1999 and 2010, a total of 37,552 women ages 35 to 70 were tested for three BRCA1 founder mutations at the outpatient genetics clinic of the Pomeranian Medical University in Szczecin, Poland. 641 women were found to carry a mutation (1.7%) and of these, 220 had a prophylactic oophorectomy (34.3%). 12 women had an occult cancer diagnosed at the time of prophylactic oophorectomy (5...
September 14, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27601060/bilateral-oophorectomy-and-breast-cancer-risk-in-brca1-and-brca2-mutation-carriers
#5
Joanne Kotsopoulos, Tomasz Huzarski, Jacek Gronwald, Christian F Singer, Pal Moller, Henry T Lynch, Susan Armel, Beth Karlan, William D Foulkes, Susan L Neuhausen, Leigha Senter, Nadine Tung, Jeffrey N Weitzel, Andrea Eisen, Kelly Metcalfe, Charis Eng, Tuya Pal, Gareth Evans, Ping Sun, Jan Lubinski, Steven A Narod
BACKGROUND: Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook a prospective analysis of bilateral oophorectomy and breast cancer risk in BRCA mutation carriers. METHODS: Subjects had no history of cancer, had both breasts intact, and had information on oophorectomy status (n = 3722). Women were followed until breast cancer diagnosis, prophylactic bilateral mastectomy, or death. A Cox regression model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of breast cancer associated with oophorectomy (coded as a time-dependent variable)...
January 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27492892/premalignant-sox2-overexpression-in-the-fallopian-tubes-of-ovarian-cancer-patients-discovery-and-validation-studies
#6
Karin Hellner, Fabrizio Miranda, Donatien Fotso Chedom, Sandra Herrero-Gonzalez, Daniel M Hayden, Rick Tearle, Mara Artibani, Mohammad KaramiNejadRanjbar, Ruth Williams, Kezia Gaitskell, Samar Elorbany, Ruoyan Xu, Alex Laios, Petronela Buiga, Karim Ahmed, Sunanda Dhar, Rebecca Yu Zhang, Leticia Campo, Kevin A Myers, María Lozano, María Ruiz-Miró, Sónia Gatius, Alba Mota, Gema Moreno-Bueno, Xavier Matias-Guiu, Javier Benítez, Lorna Witty, Gil McVean, Simon Leedham, Ian Tomlinson, Radoje Drmanac, Jean-Baptiste Cazier, Robert Klein, Kevin Dunne, Robert C Bast, Stephen H Kennedy, Bassim Hassan, Stefano Lise, María José Garcia, Brock A Peters, Christopher Yau, Tatjana Sauka-Spengler, Ahmed Ashour Ahmed
Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points over three years from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). The functional and clinical significance of the identified mutations was examined using a combination of population-based whole genome sequencing, targeted deep sequencing, multi-center analysis of protein expression, loss of function experiments in an in-vivo reporter assay and mammalian models, and gain of function experiments in primary cultured fallopian tube epithelial (FTE) cells...
August 2016: EBioMedicine
https://www.readbyqxmd.com/read/27447168/the-effect-of-referral-for-genetic-counseling-on-genetic-testing-and-surgical-prevention-in-women-at-high-risk-for-ovarian-cancer-results-from-a-randomized-controlled-trial
#7
Charles W Drescher, J David Beatty, Robert Resta, M Robyn Andersen, Kate Watabayashi, Jason Thorpe, Sarah Hawley, Hannah Purkey, Jessica Chubak, Nancy Hanson, Diana S M Buist, Nicole Urban
BACKGROUND: Guidelines recommend genetic counseling and testing for women who have a pedigree suggestive of an inherited susceptibility for ovarian cancer. The authors evaluated the effect of referral to genetic counseling on genetic testing and prophylactic oophorectomy in a randomized controlled trial. METHODS: Data from an electronic mammography reporting system identified 12,919 women with a pedigree that included breast cancer, of whom 625 were identified who had a high risk for inherited susceptibility to ovarian cancer using a risk-assessment questionnaire...
July 22, 2016: Cancer
https://www.readbyqxmd.com/read/27426853/hormone-therapy-after-prophylactic-risk-reducing-bilateral-salpingo-oophorectomy-in-women-who-have-brca-gene-mutation
#8
F Guidozzi
Women with a BRCA1 or BRCA2 gene mutation have substantially higher risk for developing not only breast and ovarian cancers, but also for primary peritoneal, Fallopian tube, colonic, pancreatic cancers, uterine papillary serous adenocarcinoma and malignant melanoma. The risk for ovarian cancer ranges from 39 to 49% by 70 years of age in BRCA1 mutation carriers and from 11 to 18% for those with a BRCA2 mutation, whilst breast cancer increases similarly within women who have either the BRCA1 mutation or the BRCA2 mutation, from about 20% in women in their forties, 37% by the age of 50 years, 55% by 60 years and more than 70% by the age of 70 years...
October 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27403072/primary-peritoneal-cancer-in-brca-carriers-after-prophylactic-bilateral-salpingo-oophorectomy
#9
Christos Iavazzo, Ioannis D Gkegkes, Nikolaos Vrachnis
OBJECTIVE: The presence of deleterious mutations in breast cancer (BRCA)-1 or BRCA-2 gene has a decisive influence on the development of various types of neoplasms, such as breast, ovarian, tubal, and peritoneal cancers. Primary peritoneal cancer is an aggressive malignancy which, due to the absence of a specific screening test, cannot be diagnosed in its early stages. As a risk-reducing option, prophylactic bilateral salpingo-oophorectomy and mastectomy are often proposed in BRCA gene carriers...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27363615/-current-surgical-practice-of-prophylactic-and-opportunistic-salpingectomy-in-france
#10
G Chene, B de Rochambeau, K Le Bail-Carval, E Beaufils, P Chabert, G Mellier, G Lamblin
OBJECTIVES: Since the recent evidence of a tubal origin of most ovarian cancers, opportunistic salpingectomy could be discussed as a prophylactic strategy in the general population and with hereditary predisposition. We aimed to survey French gynecological surgeons about their current surgical practice of prophylactic salpingectomy. METHODS: An anonymous online survey was sent to French obstetrician-gynaecologists and gynecological surgeons. There were 13 questions about their current clinical practice and techniques of salpingectomy during a benign hysterectomy or as a tubal sterilization method, salpingectomy versus salpingo-oophorectomy in the population with genetic risk, salpingectomy in relationship with endometriosis and questions including histopathological considerations...
July 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/27356721/reduced-ovarian-cancer-incidence-in-women-exposed-to-low-dose-ionizing-background-radiation-or-radiation-to-the-ovaries-after-treatment-for-breast-cancer-or-rectosigmoid-cancer
#11
Steven Lehrer, Sheryl Green, Kenneth E Rosenzweig
BACKGROUND: High dose ionizing radiation can induce ovarian cancer, but the effect of low dose radiation on the development of ovarian cancer has not been extensively studied. We evaluated the effect of low dose radiation and total background radiation, and the radiation delivered to the ovaries during the treatment of rectosigmoid cancer and breast cancer on ovarian cancer incidence. MATERIALS AND METHODS: Background radiation measurements are from Assessment of Variations in Radiation Exposure in the United States, 2011...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27230709/do-breast-cancer-survivors-benefit-from-prophylactic-removal-of-uterus-and-ovaries-a-population-based-data-linkage-replication-study
#12
Andreas Obermair, Danny Youlden, Peter Baade, Monika Janda
AIM: Our previous population-based research found prophylactic surgery (hysterectomy and bilateral salpingo-oophorectomy [BSO]) halved the mortality risk for premenopausal breast cancer patients. Here we aim to replicate findings in a Western Australia dataset. METHOD: Data from the Western Australia Cancer Registry of 15 395 women 20-79 years diagnosed with primary breast cancer (1997-2011) was categorized into four groups: neither hysterectomy nor BSO, hysterectomy only, BSO only, or hysterectomy + BSO...
May 27, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27200296/ovarian-cancer-the-fallopian-tube-as-the-site-of-origin-and-opportunities-for-prevention
#13
REVIEW
Sophia H L George, Ruslan Garcia, Brian M Slomovitz
High-grade serous carcinoma (HGSC) is the most common and aggressive histotype of epithelial ovarian cancer (EOC), and it is the predominant histotype associated with hereditary breast and ovarian cancer syndrome (HBOC). Mutations in BRCA1 and BRCA2 are responsible for most of the known causes of HBOC, while mutations in mismatch repair genes and several genes of moderate penetrance are responsible for the remaining known hereditary risk. Women with a history of familial ovarian cancer or with known germline mutations in highly penetrant genes are offered the option of risk-reducing surgery that involves the removal of the ovaries and fallopian tubes (salpingo-oophorectomy)...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27159743/the-goldilocks-quandary-of-health-care-resources-too-little-too-much-or-just-right
#14
Daniel M Morgan, Elliott Main, Rebekah E Gee
Appropriate use of health care resources is a priority for improving the quality of care. Overutilization affects almost all specialties including obstetrics and gynecology. Initiatives such as the Choosing Wisely campaign and the Joint Commission Perinatal Care Measures have brought attention to issues of overuse. The decision of these campaigns to focus on eliminating nonmedically indicated inductions before 39 weeks of gestation is an example of how more appropriate health care use can reduce complications and save millions of dollars...
June 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27050712/prophylactic-hyperthermic-intraperitoneal-chemotherapy-in-patients-with-epithelial-appendiceal-neoplasms
#15
Daniel Tuvin, Yaniv Berger, Samantha N Aycart, Tatiana Shtilbans, Spiros Hiotis, Daniel M Labow, Umut Sarpel
Background Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising approach for preventing peritoneal carcinomatosis in high-risk patients. We report our initial experience with prophylactic HIPEC in a series of patients with appendiceal neoplasms. Methods We retrospectively reviewed our prospectively maintained database to identify patients who underwent HIPEC in the absence of peritoneal disease. Patients with previously documented peritoneal surface disease were excluded. Data regarding clinical, operative and pathological features were analysed...
May 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27032642/options-in-prophylactic-surgery-to-prevent-ovarian-cancer-in-high-risk-women-how-new-hypotheses-of-fallopian-tube-origin-influence-recommendations
#16
REVIEW
Casey L Swanson, Jamie N Bakkum-Gamez
In women at increased risk of developing ovarian cancer, risk-reducing salpingo-oophorectomy is the only intervention that has been shown to decrease mortality from ovarian cancer and is the standard of care for risk reduction. Prophylactic salpingectomy with delayed oophorectomy should be considered in high-risk premenopausal women in the setting of a clinical trial.
May 2016: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/27003156/serous-tubal-intraepithelial-carcinoma-chronic-fallopian-tube-injury-and-serous-carcinoma-development
#17
Karin Malmberg, Charlotta Klynning, Angelique Flöter-Rådestad, Joseph W Carlson
Ovarian carcinoma is the deadliest gynecological malignancy. Previous studies have suggested that the fallopian tube may be the primary site for high-grade serous carcinoma. In prophylactic salpingo-oophorectomies from women with hereditary high risk for ovarian cancer, precursors can be assessed prior to onset and studied as a model for serous cancer precursor lesions. Epidemiologic studies indicate that carcinogenesis may be a result of chronic fallopian tube injury. The aims of this study were to (1) to examine the incidence of serous tubal intraepithelial carcinoma (STIC) in relation to other clinical parameters and (2) to evaluate whether chronic fallopian tube injury was related to cancer development...
June 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/26979395/effectiveness-of-prophylactic-surgeries-in-brca1-or-brca2-mutation-carriers-a-meta-analysis-and-systematic-review
#18
Xiao Li, Ran You, Xinwei Wang, Congxin Liu, Zicheng Xu, Jin Zhou, Bin Yu, Ting Xu, Hongzhou Cai, Qing Zou
PURPOSE: To systematically investigate the effectiveness of prophylactic surgeries (PS) implemented in women carrying BRCA1/2 mutations. EXPERIMENTAL DESIGN: The PubMed database was searched till August 2014 and 15 studies met the inclusion criteria. Fixed- or random-effects models were conducted according to study heterogeneity. We calculated the pooled relative risks (RR) for cancer risk or mortality along with 95% confidence intervals (CI). RESULTS: Prophylactic bilateral salpingo-oophorectomy (PBSO) and bilateral prophylactic mastectomy (BPM) were both associated with a decreased breast cancer risk in BRCA1/2 mutation carriers (RR, 0...
August 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26946931/a-new-strategy-for-prophylactic-surgery-in-brca-women-combined-mastectomy-and-laparoscopic-salpingo-oophorectomy-with-immediate-reconstruction-by-double-diep-flap
#19
V Hunsinger, A C Marchac, M Derder, M Hivelin, F Lecuru, A-S Bats, L Lantieri
BACKGROUND: Prophylactic surgery remains the most effective modality for reducing both breast and ovarian cancer rate in woman at high risk, such as BRCA1 or BRCA2. Autologous breast reconstruction with bilateral deep inferior epigastric perforator (DIEP) flap allows predictable and durable results. However, existing two-step approach separating salpingo-oophorectomy and reconstruction could even make DIEP flap impossible, or make insufflation more difficult during laparoscopy. Other authors described one-step procedure but with open laparotomy...
June 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/26928677/prophylactic-salpingo-oophorectomy-in-brca1-mutation-carriers-and-postoperative-incidence-of-peritoneal-and-breast-cancers
#20
Janusz Menkiszak, Anita Chudecka-Głaz, Jacek Gronwald, Aneta Cymbaluk-Płoska, Aleksander Celewicz, Maria Świniarska, Małgorzata Wężowska, Ryszard Bedner, Dorota Zielińska, Paulina Tarnowska, Jerzy Jakubowicz, Zbigniew Kojs
BACKGROUND: There are no effective methods of diagnosis of early-stage ovarian cancer. Conservative care over patients at high risk of ovarian and breast cancers is ineffective. Prophylactic surgery is considered the best prophylaxis among BRCA1/BRCA2 carriers. METHODS: One hundred ninety-five patients, carriers of one of three most common mutations of the BRCA1 gene (Am J Hum Genet: 66: (6)1963-1968, 2000) in the Polish population (5382insC, 4153delA and C61G), who undergone prophylactic salpingo-oophorectomy...
2016: Journal of Ovarian Research
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