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JOURNAL ARTICLE
Kazushi Hirono, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
PURPOSE: This study investigates the visual outcomes of neovascular age-related macular degeneration (nAMD) patients who developed intraocular inflammation (IOI) after intravitreal brolucizumab injection (IVBr). METHODS: We studied 285 eyes of 279 cases diagnosed with nAMD and focused on 18 eyes (6.3%) of 17 cases which developed IOI after IVBr. IVBr was performed either on the initial treatment or for switching of other anti-vascular endothelial growth factor agents during January 2020 to December 2021...
2024: PloS One
#2
JOURNAL ARTICLE
Patching in Children With Unilateral Congenital Cataract and Child Functioning and Parenting Stress.
Carolyn Drews-Botsch, George Cotsonis, Marianne Celano, E Eugenie Hartmann, Jaffer Zaidi, Scott R Lambert
IMPORTANCE: Parents may be concerned about the adverse outcomes of occlusion therapy in children treated for unilateral congenital cataract (UCC). OBJECTIVE: To determine whether occlusion therapy in children treated for UCC with poor visual outcomes is negatively associated with poorer child and/or family functioning. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted in 2023 using data collected between 2006 and 2016 in the Infant Aphakia Treatment Study (IATS)...
April 18, 2024: JAMA Ophthalmology
#3
JOURNAL ARTICLE
Marci L Gaither, Elena D Bassett, Amy L Wilson, Stephen R Marder, Daniel W Bradford, Jared D Bernard, Shirley M Glynn
Individuals living with psychosis are often underserved in the United States, partly due to the dearth of providers trained in evidence-based practices for this population. One such practice is Cognitive Behavioral Therapy for psychosis, which the Substance Abuse and Mental Health Services Administration has identified as a standard of care for this population. The explosion of telehealth, in large part due to the COVID-19 pandemic, has led to increased opportunities for virtual psychotherapy. Telehealth offers a number of benefits, such as the ability to address service inequities, including lack of access to a local provider well-trained in the modality of therapy needed...
April 18, 2024: Psychological Services
#4
JOURNAL ARTICLE
Claire Houtsma, Amanda M Raines, Amanda H Kerbrat, Gala True
The primary purpose of this single-arm mixed-methods pilot trial was to examine the feasibility, acceptability, and preliminary effects of a text message-based version of Caring Contacts, Caring Contacts texts (CC-t), among veterans recently separated from military service. Twenty-four veterans ( M age = 32.92, SD = 8.16; 75% male; 50% Black; 91.7% non-Hispanic/Latinx) were recruited through the Department of Veterans Affairs (VA) and enrolled in CC-t, which involved approximately five text messages sent by the study team expressing care and concern over the course of 3 months...
April 18, 2024: Psychological Services
#5
JOURNAL ARTICLE
Emily C Williams, Madeline C Frost, Mark Bounthavong, Amy T Edmonds, Marcos K Lau, E Jennifer Edelman, Michael A Harvey, Melissa L D Christopher
BACKGROUND: The Veterans Health Administration (VA) implemented academic detailing (AD) to support safer opioid prescribing and overdose prevention initiatives. METHODS: Patient-level data were extracted monthly from VA's electronic health record to evaluate whether AD implementation was associated with changes in all-cause mortality, opioid poisoning inpatient admissions, and opioid poisoning emergency department (ED) visits in an observational cohort of patients with long-term opioid prescriptions (≥45-day supply of opioids 6 months prior to a given month with ≤15 days between prescriptions)...
April 18, 2024: Subst Use Addctn J
#6
JOURNAL ARTICLE
Jeff P Sharman, Paolo Ghia, Paulo Miranda, Naghmana Bajwa, Simon Rule, Bob Shaw, John F Seymour
This analysis investigated the incidence of sudden deaths (SDs) and non-fatal and fatal ventricular arrhythmias (VAs) in five acalabrutinib clinical trials. In total, 1299 patients received acalabrutinib (exposure, 4568.4 patient-years). Sixteen (1.2%) patients experienced SD or VA (event rate, 0.350/100 patient-years). Non-fatal VAs occurred in 11 (0.8%) patients, nine (0.7%) of whom had premature ventricular contractions only. SD and fatal VAs occurred in five (0.4%) patients (event rate, 0.109/100 patient-years; median time to event: 46...
April 17, 2024: British Journal of Haematology
#7
REVIEW
Lan Chen, Yuan Zhang, Yi-Xin Zhang, Wei-Lai Wang, De-Mei Sun, Peng-Yun Li, Xue-Song Feng, Yue Tan
Tyrosine kinase inhibitors (TKIs) have emerged as the first-line small molecule drugs in many cancer therapies, exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways. However, there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites, which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments, alongside other potential side effects or adverse reactions...
April 2024: Journal of Pharmaceutical Analysis
#8
Yuki Yamafuji, Masafumi Suga, Seiya Fujisawa, Gentoku Oosuki, Takuya Taira, Ryo Takahashi, Shigenari Matsuyama, Satoshi Ishihara
Fat embolism syndrome (FES) is a rare complication of long bone fractures, with fulminant FES developing within 12 h of injury and often proving fatal (Shaikh, 2009 [1]). Here, we present a case of fulminant FES in a patient who developed sudden right heart failure after undergoing external fixation of a lower leg fracture and required veno-arterial extracorporeal membrane oxygenation (VA-ECMO). A 79-year-old woman injured in a traffic accident was transferred to our emergency department. Upon arrival, her level of consciousness deteriorated, and she developed circulatory failure...
June 2024: Trauma Case Reports
#9
JOURNAL ARTICLE
Augusto Arias, Diego Montagud-Martinez, Pablo Artal
Both cataracts and age-related macular degeneration (AMD) may occur with aging and are often developed simultaneously. We performed a study to better characterize the impact of induced scatter on the quality of vision in the near periphery, a region where individuals with AMD typically maintain their functional vision. We used an optical instrument as a cataract simulator based on projecting at the eye's pupil plane phase masks with controlled spatial properties generated with a spatial light modulator. The phase wavefronts were designed to accurately replicate the angular distribution of light intensity in the retina found in cataractous eyes with different severities...
April 1, 2024: Biomedical Optics Express
#10
JOURNAL ARTICLE
Heather M Gilmartin, Brigid Connelly, Edward Hess, Candice Mueller, Mary E Plomondon, Stephen W Waldo, Catherine Battaglia
INTRODUCTION: Despite the Veterans Health Administration (VA) efforts to become a learning health system (LHS) and high-reliability organization (HRO), interventions to build supportive learning environments within teams are not reliably implemented, contributing to high levels of burnout, turnover, and variation in care. Supportive learning environments build capabilities for teaching and learning, empower teams to safely trial and adapt new things, and adopt highly reliable work practices (eg, debriefs)...
April 2024: Learning Health Systems
#11
JOURNAL ARTICLE
Atsuyuki Mitsuishi, Yujiro Miura, Yoshinori Nomura, Takayoshi Hirota, Naoki Arima, Hiroaki Kitaoka, Hiroki Tateiwa, Yoshifumi Katsumata
BACKGROUND: There is insufficient information regarding the bleeding sites and surgical strategies of cardiac tamponade during catheter ablation for atrial fibrillation (AF). CASE PRESENTATION: Of the five patients with cardiac tamponade, three required surgical intervention and two required pericardiocentesis. In the first case of three cardiac tamponades requiring surgical intervention, considering that the peripheral route was used, the catecholamines did not reach the heart, and due to unstable vital signs, venoarterial extracorporeal membrane oxygenation (VA-ECMO) was inserted...
April 17, 2024: Journal of Cardiothoracic Surgery
#12
JOURNAL ARTICLE
Edward Mbonigaba, Fengyun Yu, Mark Donald C Reñosa, Frederick Nchang Cho, Qiushi Chen, Claudia M Denkinger, Shannon A McMahon, Simiao Chen
INTRODUCTION: Knowledge and trust are some of the contributing factors to vaccine acceptance(VA) and Vaccine hesitancy (VH) is one of the top threats to global health. A significant drop in childhood vaccination has been observed in recent years. One important reason that influences mothers' choice to either postpone or avoid children's vaccinations is knowledge and trust in childhood vaccines. This study aimed to assess mothers' knowledge and trust on vaccination of their children, and to examine the association between vaccination knowledge and selected socio-demographic factors...
April 17, 2024: BMC Public Health
#13
JOURNAL ARTICLE
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J Carey, David E Kaplan, Julie Lynch, Timothy Morgan, Tae-Hwi Schwantes-An, Daniel R Dochtermann, Saiju Pyarajan, Philip S Tsao, Triin Laisk, Reedik Mägi, Julia Kozlitina, Anne Tybjærg-Hansen, David Jones, Kirk U Knowlton, Lincoln Nadauld, Egil Ferkingstad, Einar S Björnsson, Magnus O Ulfarsson, Árni Sturluson, Patrick Sulem, Ole B Pedersen, Sisse R Ostrowski, Daniel F Gudbjartsson, Kari Stefansson, Morten Salling Olesen, Kyong-Mi Chang, Hilma Holm, Henning Bundgaard, Stefan Stender
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism...
April 17, 2024: Nature Genetics
#14
JOURNAL ARTICLE
Brystana G Kaufman, S Nicole Hastings, Cassie Meyer, Karen M Stechuchak, Ashley Choate, Kasey Decosimo, Caitlin Sullivan, Virginia Wang, Kelli D Allen, Courtney H Van Houtven
OBJECTIVE: To conduct a business case analysis for Department of Veterans Affairs (VA) program STRIDE (ASsisTed EaRly MobIlization for hospitalizeD older VEterans), which was designed to address immobility for hospitalized older adults. DATA SOURCES AND STUDY SETTING: This was a secondary analysis of primary data from a VA 8-hospital implementation trial conducted by the Function and Independence Quality Enhancement Research Initiative (QUERI). In partnership with VA operational partners, we estimated resources needed for program delivery in and out of the VA as well as national implementation facilitation in the VA...
April 17, 2024: Health Services Research
#15
JOURNAL ARTICLE
Ondřej Rýdlo, Adéla Bubeníková, Klára Häcklová, Petr Skalický, Róbert Leško, Adéla Ebelová, David Netuka, Vladimír Beneš IIIrd, Vladimír Beneš, Ondřej Bradáč
We sought to describe the cognitive profile of patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) using a comprehensive neuropsychological battery. Based on age and education correlated norms, we aimed to compare performance in each measured cognitive domain: executive functions (EFs), verbal memory (VM), non-verbal memory (nVM), visuoconstructional abilities (VA) and attention/psychomotor speed (A/PS). Patients diagnosed with iNPH underwent comprehensive neuropsychological evaluation before shunting...
April 17, 2024: Neurosurgical Review
#16
JOURNAL ARTICLE
Hashem Saffarian, Ebrahim Rahimi, Faham Khamesipour, Seyed Majid Hashemi Dehkordi
Today, microbial contamination in food is one of the major problems of the food industry and public health in general around the world. Foodborne illnesses, such as diarrheal diseases, kill many people around the world each year. The general objective of this study was to evaluate the antioxidant and antibacterial activity of sodium alginate nanoemulsion coating incorporated with oregano essential oil ( Origanum vulgare L.) and Trachyspermum ammi oil ( Carum cupticum ) on Escherichia coli , and Listeria monocytogenes ...
April 2024: Food Science & Nutrition
#17
JOURNAL ARTICLE
Rachel L Bachrach, Caitlan A Tighe, Nicole Beyer, Kristina Hruska, Angela Phares, Karley Atchison, Lynn Baniak, Gretchen Haas, Adam D Bramoweth
OBJECTIVES: Study objectives were to: (1) better understand sleep experiences and unhealthy alcohol use among Veterans with long COVID and (2) explore providers' perceptions of barriers and facilitators to delivering evidence-based care for sleep problems and unhealthy alcohol use in patients with long COVID. METHODS: VA electronic health records were used to conduct chart reviews (n = 57) of patients evaluated in a VA COVID-19 Recovery Clinic during 1 calendar year; semi-structured interviews were completed with Veterans (n = 5) and clinicians (n = 7) recruited from the clinic...
2024: Journal of Primary Care & Community Health
#18
JOURNAL ARTICLE
Thomas F Osborne, Zachary P Veigulis, Anna Ware, David M Arreola, Catherine Curtin, Marianne Yeung
BACKGROUND: Terminally ill patients benefit from earlier engagement in palliative care. However, this does not always occur. This project assessed if an already available risk score, the Care Assessment Needs (CAN) score, would be able to identify patients at greatest risk for mortality within 30 days of hospital admission within the Veterans Health Administration (VHA). METHODS: The cohort of this retrospective analysis included all VA acute are patients over 18 years of age with a recent CAN score...
April 16, 2024: American Journal of Hospice & Palliative Care
#19
JOURNAL ARTICLE
Armin Handzic, Jim Shenchu Xie, Eef Hendriks, Pascal Mosimann, Patrick Nicholson, Jonathan Micieli, Edward Margolin
BACKGROUND: Transverse sinus stenting (TSS) is an increasingly common treatment for patients with idiopathic intracranial hypertension (IIH). However, detailed neuro-ophthalmic evidence on visual and pharmacotherapy outcomes after TSS is scarce and heterogeneous. This study aimed to describe the visual outcomes of patients undergoing TSS for IIH and to ascertain the proportion of patients who could be weaned off intracranial pressure (ICP)-lowering medication postoperatively. METHODS: A retrospective chart review of all patients with IIH from 2 tertiary academic neuro-ophthalmology practices who underwent TSS between 2016 and 2022 was performed...
April 17, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#20
JOURNAL ARTICLE
Matheus Senna Pereira Ogata, Guilherme Rodrigues Ferreira, Melina Correia Morales, Arthur Gustavo Fernandes
OBJECTIVE: Ocular metastases are the most common intraocular tumours in adults. Data regarding the occurrence of these tumours in the Brazilian population is scarce. We aimed to investigate the profile of ocular metastases of patients referred to tertiary hospital service in São Paulo, Brazil. DESIGN: Retrospective study. PARTICIPANTS: Patients referred to the Ocular Oncology service of the Federal University of São Paulo with initial diagnostic hypothesis of ocular metastasis...
April 16, 2024: International Journal of Retina and Vitreous
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