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https://www.readbyqxmd.com/read/28528185/simvastatin-ameliorate-memory-deficits-and-inflammation-in-clinical-and-mouse-model-of-alzheimer-s-disease-via-modulating-the-expression-of-mir-106b
#1
Wenzhong Huang, Zhenyu Li, Liandong Zhao, Wei Zhao
BACKGROUND: Alzheimer's disease (AD) as a neurodegenerative brain disorder is a devastating pathology leading to disastrous cognitive impairments and dementia, and several studies have shown that AD is closely related to the inflammation, so anti-inflammatory treatment may provide therapeutic benefits. In this study, the effect of simvastatin on inflammation was investigated and the underlying mechanisms were explored. METHODS: First, we tested the effect of simvastatin on AD in clinical research...
May 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28527962/resolution-of-mitral-regurgitation-with-left-ventricular-assist-device-support
#2
Matthew Goodwin, Hassan W Nemeh, Jamil Borgi, Gaetano Paone, Jeffrey A Morgan
BACKGROUND: Cardiac valve disease is common in patients with end-stage heart failure undergoing left ventricular assist device implantation (LVAD). The aim of this study was to determine if preoperative mitral regurgitation (MR) affects outcomes and hemodynamics in patients after LVAD implantation. METHODS: From March 2006 through May 2015, 238 consecutive patients underwent LVAD implantation. Patient cohorts included less than moderate to severe MR (< moderate-severe, n = 195) and greater than or equal to moderate to severe MR (≥ moderate-severe, n = 43)...
May 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28527174/cerebral-venous-sinus-thrombosis-and-posterior-reversible-encephalopathy-syndrome-coexisting-in-a-woman-a-rare-coincidence
#3
Surekha Dabla, Himanshu Juneja, Anubha Garg, Renu Bansal, Surender Kumar
Cerebral venous sinus thrombosis (CVST) and posterior reversible encephalopathy syndrome (PRES) are two rare diseases which may present with similar symptoms and signs. We report a case with coexisting PRES and CVST in a 34 years old postpartum female presented with multiple episodes of generalized seizures and bilateral vision loss after delivery. MRI brain and venography revealed left transverse sinus, sigmoid sinus and internal cerebral vein thrombosis with vasogenic edema in bilateral parieto-occipital, right temporal and left frontal area, which was suggestive of posterior reversible encephalopathy syndrome (PRES)...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28527136/factors-influencing-non-albicans-candidemia-a-case-case-control-study
#4
Diamantis P Kofteridis, Antonis Valachis, Dimitra Dimopoulou, Angeliki M Andrianaki, Athanasia Christidou, Sofia Maraki, Nikolaos A Spernovasilis, George Samonis
The study identified factors predisposing to non-albicans candidemia with special interest to prior antimicrobial treatment. A retrospective, case-case-control study was performed at the University Hospital of Heraklion, Greece, from November 2007 through September 2011 including adult patients. The study had three groups. The first included 58 patients with non-albicans candidemia, the second 48 with C. albicans candidemia, while the third (control) 104 without candidemia. Each of the two candidemia groups was compared with the control using multivariate logistic regression model...
May 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28527110/a-review-of-the-hemodynamic-factors-believed-to-contribute-to-vascular-access-dysfunction
#5
Connor V Cunnane, Eoghan M Cunnane, Michael T Walsh
A vascular access (VA) is used to facilitate hemodialysis in patients that suffer from end-stage renal disease. However, they suffer from high failure rates due to non-maturation and venous stenosis, with intimal hyperplasia (IH) the underlying cause of both conditions. Abnormal hemodynamic profiles, which arise following VA creation, are believed to lead to the development of IH. However, the exact physiological response that initiates this process is unknown. This review evaluates the different hemodynamic parameters that are hypothesised to correlate with the development of IH...
May 19, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28526604/extramural-perineural-invasion-in-pt3-and-pt4-rectal-adenocarcinoma-as-prognostic-factor-after-preoperative-chemoradiotherapy
#6
Leonardo S Lino-Silva, Rosa A Salcedo-Hernández, Alejandro España-Ferrufino, Erika B Ruiz-García, Miguel Ruiz-Campos, Alberto M León-Takahashi, Abelardo Meneses-García
Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated in the head and neck and prostate carcinomas, but its significance in rectal cancer is controversial. Most studies have focused on evaluating mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis after rectal cancer resection. We evaluated the prognostic value of ePNI compared with mPNI and with non-PNI, in rectal resections after preoperative chemoradiotherapy in 148 patients with pT3 and pT4 rectal carcinomas...
May 16, 2017: Human Pathology
https://www.readbyqxmd.com/read/28524151/-etiopathogenesis-of-ocular-ischemic-syndrome
#7
D К Makhkamova
Ocular ischemic syndrome (OIS) is a collection of symptoms of carotid and ophthalmic artery disease of common genesis accompanied by ischemia of eyeball membranes. Specifically, the intraocular blood flow becomes impaired due to inflow reduction or arrest, while the venous outflow remains patent. Causes of OIS include arterial hypertension, atherosclerosis, diabetes, aortoarteritis and other vascular diseases. Clinical features depend on the extent, nature, and site of vascular involvement as well as the concurrent pathology...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28524125/-surgical-management-of-venous-compression-causing-trigeminal-neuralgia
#8
V K Poshataev, A N Konovalov, V N Shimanskiy
Venous compression is a rare cause of trigeminal neuralgia (TN). Vascular decompression of the trigeminal nerve root, as the only etiopathogenetic treatment of trigeminal neuralgia, is a well-known procedure that is extensively used at various neurosurgical clinics. As the number of interventions for TN increases, the absolute number of surgeries for eliminating venous compression of the trigeminal nerve also grows. Five hundred TN patients underwent surgery at the Neurosurgical Institute in the period from 2000 to 2015...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28523345/endovenous-laser-ablation-therapy-in-children-applications-and-outcomes
#9
Premal A Patel, Alex M Barnacle, Sam Stuart, Joao G Amaral, Philip R John
BACKGROUND: Endovenous laser ablation is well recognized as the first-line treatment for superficial venous reflux with varicose veins in adults. It is not widely reported and is not an established practice in pediatric patients. OBJECTIVE: To illustrate a variety of pediatric venous conditions in which endovenous laser ablation can be utilized and to demonstrate its feasibility and safety in children. MATERIALS AND METHODS: We conducted a retrospective review of endovenous laser ablation procedures performed between January 2007 and July 2014 at two large pediatric institutions...
May 18, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28522650/examining-the-association-between-hemodialysis-access-type-and-mortality-the-role-of-access-complications
#10
Pietro Ravani, Robert Quinn, Matthew Oliver, Bruce Robinson, Ronald Pisoni, Neesh Pannu, Jennifer MacRae, Braden Manns, Brenda Hemmelgarn, Matthew James, Marcello Tonelli, Brenda Gillespie
BACKGROUND AND OBJECTIVES: People receiving hemodialysis to treat kidney failure need a vascular access (a fistula, a graft, or a central venous catheter) to connect to the blood purification machine. Higher rates of access complications are considered the mechanism responsible for the excess mortality observed among catheter or graft users versus fistula users. We tested this hypothesis using mediation analysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied incident patients who started hemodialysis therapy from North America, Europe, and Australasia (the Dialysis Outcomes and Practice Patterns Study; 1996-2011)...
May 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28521623/enzyme-linked-immunoassay-based-quantitative-measurement-of-apolipoprotein-b-apob-in-dried-blood-spots-a-biomarker-of-cardiovascular-disease-risk
#11
Geeta N Eick, Paul Kowal, Tyler Barrett, Elizabeth A Thiele, J Josh Snodgrass
Apolipoprotein B (ApoB) is a strong predictor of cardiovascular disease, which remains the leading cause of mortality in both higher and lower income countries. Here, we adapted an enzyme-linked immunosorbent assay (ELISA) development kit for quantitative determination of ApoB levels in serum and plasma for use with dried blood spots (DBS). After confirming the dilution linearity of the assay for DBS, we measured ApoB in 208 venous DBS samples. Then, using Passing-Bablok regression analysis and Spearman rank correlation analysis, we evaluated the correspondence in ApoB values between matched plasma and finger-prick DBS samples from 40 individuals who had ApoB values spanning the range of ApoB values observed in the 208 vDBS samples...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/28516797/blood-glucose-and-insulin-and-correlation-of-slc25a13-mutations-with-biochemical-changes-in-niccd-patients
#12
Chun-Ting Lu, Qi-Ping Shi, Ze-Jian Li, Jiong Li, Lie Feng
Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is a hereditary metabolic disease arising from biallelic mutations of SLC25A13. This study aimed to explore the characteristics of fasting blood glucose (FBG), fasting insulin (FINS) and C-peptide (C-P) levels in NICCD infants, analyze their SLC25A13 genetic mutations and further discuss the correlation between SLC25A13 genetic mutations and biochemical changes. Seventy-two cases of infants with cholestasis disease were gathered. Among them, 36 cases with NICCD diagnosis were case group...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28515117/venous-thromboembolism-risk-with-antidepressants-driven-by-disease-or-drugs
#13
EDITORIAL
Brian R Branchford
No abstract text is available yet for this article.
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28514785/effect-of-age-on-the-association-of-vascular-access-type-with-mortality-in-a-cohort-of-incident-end-stage-renal-disease-patients
#14
Tarek Saleh, Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Geeta G Gyamlani, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND/AIMS: All hemodialysis (HD) patients are generally recommended to create a fistula first; but to create a mature arteriovenous fistula (AVF) can be challenging in elderly individuals. It is unclear if elderly incident HD patients derive a survival benefit from an AVF over an arteriovenous graft (AVG) or a tunneled central venous catheter (TDC). METHODS: We examined the association of vascular access type (AVF, AVG, and TDC with and without a maturing AVF/AVG at dialysis transition) at HD initiation with all-cause, cardiovascular (CV), and infection-related mortality in 46,786 US veterans using Cox models with adjustment for confounders...
May 18, 2017: Nephron
https://www.readbyqxmd.com/read/28514385/-the-effects-of-diosmin-and-hesperidin-on-capillary-blood-flow-of-upper-limbs-in-patients-with-secondary-raynaud-s-syndrome
#15
A M Zudin, A G Gritsenko, I T Hadzhishvili
The article discusses the effects of diosmin and hesperidin on capillary blood flow in patients with secondary Raynaud's syndrome (RS). Raynaud's syndrome a difficult problem of modern angiology, since in its development there is a large range of disorders of the capillary blood flow of the limbs. Currently, the main way of therapy in patients with secondary Raynaud's syndrome is the use of either calcium channel blockers (if angiospastic stage of the disease), or prostaglandins of group E1 (with tropho-paralytic stage of secondary RS)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28512406/a-case-of-subcutaneous-sarcoidosis-occurring-along-the-superficial-veins-of-the-forearms-a-distinctive-cutaneous-manifestation-masquerading-venous-tropic-action-in-the-underlying-systemic-disease
#16
Haruka Koizumi, Noritaka Oyama, Yukinori Hayakawa, Minoru Hasegawa
Sarcoidosis is a multisystem disease of unknown etiology, developing granulomas in any tissues and organs. Approximately 25% of sarcoidosis patients have cutaneous involvement with various clinical manifestations, which are categorized into specific or nonspecific diseases based on the histopathology; the former represents the typical sarcoid granulomas. Subcutaneous sarcoidosis is one of the specific skin lesions and often affects extremities, to a much lesser extent with other anatomical sites. Herein, we report the case of an 82-year-old Japanese man with subcutaneous sarcoidosis whose skin nodules exclusively overlay the lines of superficial veins on the forearms...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28511440/portal-venous-thrombosis-eosinophilic-vasculitis
#17
Vasanthi Natarajan, David Jose, Kevin John, Ashok Kumar Das
Portal Vein Thrombosis (PVT) is caused by various thrombophilic states. PVT secondary to underlying vasculitis especially Churg-Strauss disease is among the rarest presentation. Here, we report a case of peripheral eosinophilia, eosinophilic ascitis and venous thrombosis involving portal vein and superior mesenteric vein diagnosed as Churg-Strauss Syndrome (CSS). He was managed with steroids and anticoagulants. Following initiation of steroids, eosinophilia and eosinophilic ascitis improved.
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511346/potential-therapeutic-action-of-nitrite-in-sickle-cell-disease
#18
Nadeem Wajih, Swati Basu, Anuj Jailwala, Hee Won Kim, David Ostrowski, Andreas Perlegas, Crystal A Bolden, Nancy L Buechler, Mark T Gladwin, David L Caudell, Elaheh Rahbar, Martha A Alexander-Miller, Vidula Vachharajani, Daniel B Kim-Shapiro
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in hemolysis, which reduces nitric oxide (NO) bioavailability, and induces platelet activation and inflammation leading to adhesion of circulating blood cells. Nitric Oxide inhibits adhesion and platelet activation. Nitrite has emerged as an attractive therapeutic agent that targets delivery of NO activity to areas of hypoxia through bioactivation by deoxygenated red blood cell hemoglobin...
May 10, 2017: Redox Biology
https://www.readbyqxmd.com/read/28511163/-impact-of-physical-activity-on-anthropometric-indices-in-patients-with-nonalcoholic-fatty-liver-disease-and-pre-diabetes-or-type-2-diabetes
#19
Віталіна В Івачевська
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease in many developed countries. The first step, which is offered to all patients with NAFLD includes lifestyle modifications, low-calorie diet, increased physical activity and giving up smoking. OBJECTIVE: to evaluate the efficiency of the daily 30-minute walking at a fast pace on the dynamics of anthropometric indices in patients with NAFLD and pre-diabetes or type 2 diabetes...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28511158/evolution-of-some-indicators-of-systemic-immunity-in-patients-with-acne-while-using-laser-therapy
#20
Marianna Dashko, Orysya Syzon, Iryna Voznyak
INTRODUCTION: One of the important problems in modern dermatology is to improve treatment efficiency of acne being a common cause for cicatricial skin changes, loss of performance capability and social activity and negatively affects the psycho-emotional state of patients and their quality of life. The topicality of the disease is due to the high degree of its proliferation, chronic and recurrent course, and resistance to existing therapies. Reducing the effectiveness of skin diseases treatment, including that of acne, at present, is associated with developing resistance to drugs, which causes the use of non-drug methods in dermatology nowadays, including low-intensity laser therapy...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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