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pathophysiology of burn

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https://www.readbyqxmd.com/read/29791992/role-of-the-duodenum-in-the-pathogenesis-of-functional-dyspepsia-a-paradigm-shift
#1
REVIEW
Hye-Kyung Jung, Nicholas J Talley
Functional dyspepsia (FD) is a common disorder characterized by chronic epigastric pain or burning, or bothersome postprandial fullness or early satiation, without a definitive organic cause. The pathogenesis of FD is likely heterogeneous. Classically, motor disorders, visceral hypersensitivity, and brain-gut interactions have been implicated in the pathophysiology of FD, but recently an important role for chronic low-grade inflammation and post-infectious gastroenteritis in FD has been reported and confirmed...
May 23, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29786812/the-microrna-expression-profile-in-rat-lung-tissue-early-after-burn-injury
#2
Donghai Zhang, Yang Chang, Shaofang Han, Longlong Yang, Quan Hu, Yonghui Yu, Lingying Liu, Jiake Chai
BACKGROUND: Severe burn causes acute lung injury in many victims, but the related mechanisms have been barely investigated. microRNAs (miRNAs) important regulators in numerous physiological and pathophysiological process. However, the roles of miRNAs in burn lung injury are untested. METHODS: Six healthy male Sprague-Dawley rats were randomly assigned into burn and sham groups. Lung injury was evaluated by hematoxylin and eosin (HE) staining at 24 h after injury...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29777310/mechanical-sensitivity-and-psychological-factors-in-patients-with-burning-mouth-syndrome
#3
Mika Honda, Takashi Iida, Hirona Kamiyama, Manabu Masuda, Misao Kawara, Peter Svensson, Osamu Komiyama
OBJECTIVES: The aim of this study was to compare mechanical sensitivity on the tongue using quantitative sensory testing (QST) and psychological factors using the General Health Questionnaire (GHQ) between burning mouth syndrome (BMS) patients and healthy participants. MATERIALS AND METHODS: Participants comprised 20 female BMS patients (68.1 ± 7.4 years) and 20 healthy females (65.4 ± 4.6 years). Psychological factors were evaluated with GHQ. Tactile detection thresholds (TDT) and filament-prick pain detection thresholds (FPT) were used to evaluate mechanical sensitivity on the tongue in all participants...
May 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29762485/stress-induced-and-diabetic-hyperglycemia-associated-with-higher-mortality-among-intensive-care-unit-trauma-patients-cross-sectional-analysis-of-the-propensity-score-matched-population
#4
Meng-Wei Chang, Chun-Ying Huang, Hang-Tsung Liu, Yi-Chun Chen, Ching-Hua Hsieh
BACKGROUND: This study was designed to measure the effect of stress-induced hyperglycemia (SIH) and diabetic hyperglycemia (DH) versus non-diabetic normoglycemia (NDN) on the outcomes of trauma patients in the intensive care unit (ICU). METHODS: Diabetes mellitus (DM) was determined based on patient history and/or a hemoglobin A1c (HbA1c) level of ≥6.5% at admission. The patients who had serum glucose levels of ≥200 mg/dL in the absence or presence of DM were assigned into the groups SIH and DH, respectively...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29740349/severe-burn-induced-intestinal-epithelial-barrier-dysfunction-is-associated-with-endoplasmic-reticulum-stress-and-autophagy-in-mice
#5
Yalan Huang, Yanhai Feng, Yu Wang, Pei Wang, Fengjun Wang, Hui Ren
The disruption of intestinal barrier plays a vital role in the pathophysiological changes after severe burn injury, however, the underlying mechanisms are poorly understood. Severe burn causes the disruption of intestinal tight junction (TJ) barrier. Previous studies have shown that endoplasmic reticulum (ER) stress and autophagy are closely associated with the impairment of intestinal mucosa. Thus, we hypothesize that ER stress and autophagy are likely involved in burn injury-induced intestinal epithelial barrier dysfunction...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29718376/assessment-of-ablative-fractional-co2-laser-and-er-yag-laser-to-treat-hypertrophic-scars-in-a-red-duroc-pig-model
#6
Luis Rodriguez-Menocal, Stephen S Davis, Sandra Becerra, Marcela Salgado, Joel Gill, Jose Valdes, Ambar Candanedo, Shanmugasundaram Natesan, Michael Solis, Wellington Guzman, Alex Higa, Carl I Schulman, Robert J Christy, Jill Waibel, Evangelos V Badiavas
Hypertrophic scarring is a fibroproliferative process that occurs following a third-degree dermal burn injury, producing significant morbidity due to persistent pain, itching, cosmetic disfigurement, and loss of function due to contractures. Ablative fractional lasers have emerged clinically as a fundamental or standard therapeutic modality for hypertrophic burn scars. Yet the examination of their histopathological and biochemical mechanisms of tissue remodeling and comparison among different laser types has been lacking...
April 28, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29690735/-lay-emphasis-on-circulatory-state-research-after-fluid-resuscitation-in-early-burns
#7
Q Zhang, Y Q Tang
In this article, we discuss future development of circulatory state research after fluid resuscitation in early burns from its history and difficulties confronted. We believe that the Chinese fluid resuscitation formula to predict initial volume of fluid infusion of extensive burn patients is still useful and effective, while we should attach more importance to advances in the research of burn pathophysiology, basic theory and clinical practices of Chinese fluid resuscitation formula, so as to provide strategy of fluid resuscitation in early burns for international burn world...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29596679/burn-injuries-in-patients-with-paralysis-a-national-perspective-on-injury-patterns-and-outcomes
#8
Christina E Stiles, Melissa M McLawhorn, Lauren B Nosanov, Jennifer L Paul, Jeffrey W Shupp
The affect of paralysis-related comorbidities on outcomes in burn-injured patients has not been explored. We hypothesize that comorbid paralysis is associated with increased morbidity in this population. All burned patients with prior diagnoses of paralysis were identified from the National Burn Repository (Version 8.0). One-to-one matching of nonparalyzed burn-injured patients was performed, and nonparametric analysis was used to compare the groups. We identified 432 paralyzed patients, who were predominantly male (70...
December 27, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29518352/loss-of-cone-function-without-degeneration-in-a-novel-gnat2-knock-out-mouse
#9
Kaitryn E Ronning, Gabriel Peinado Allina, Eric B Miller, Robert J Zawadzki, Edward N Pugh, Rolf Herrmann, Marie E Burns
Rods and cones mediate visual perception over 9 log units of light intensities, with both photoreceptor types contributing to a middle 3-log unit range that comprises most night-time conditions. Rod function in this mesopic range has been difficult to isolate and study in vivo because of the paucity of mutants that abolish cone signaling without causing photoreceptor degeneration. Here we describe a novel Gnat2 knockout mouse line (Gnat2-/- ) ideal for dissecting rod and cone function. In this line, loss of Gnat2 expression abolished cone phototransduction, yet there was no loss of cones, disruption of the photoreceptor mosaic, nor change in general retinal morphology up to at least 9 months of age...
March 5, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29507908/understanding-of-burning-mouth-syndrome-based-on-psychological-aspects
#10
Moon-Jong Kim, Hong-Seop Kho
Burning mouth syndrome (BMS) is a chronic pain condition characterised by a persistent burning sensation in clinically normal oral mucosa. BMS most commonly occurs in middleaged and elderly women. Various local and systemic factors can cause oral burning symptoms. When all possible local and systemic factors are excluded, burning mouth symptoms can be diagnosed as BMS. Psychophysical tests and histopathological data suggest the involvement of peripheral and central neuropathic mechanisms in BMS etiopathogenesis...
2018: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/29505817/assessment-of-the-impact-of-aerosol-from-a-potential-modified-risk-tobacco-product-compared-with-cigarette-smoke-on-human-organotypic-oral-epithelial-cultures-under-different-exposure-regimens
#11
Filippo Zanetti, Alain Sewer, Elena Scotti, Bjoern Titz, Walter K Schlage, Patrice Leroy, Athanasios Kondylis, Gregory Vuillaume, Anita R Iskandar, Emmanuel Guedj, Keyur Trivedi, Thomas Schneider, Ashraf Elamin, Florian Martin, Stefan Frentzel, Nikolai V Ivanov, Manuel C Peitsch, Julia Hoeng
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk tobacco product (MRTP) based on heat-not-burn technology. Using a systems toxicology assessment framework, we compared the effects of exposure to CHTP1.2 aerosol with those of CS from a reference cigarette (3R4F)...
May 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29461292/inhalation-injury-in-the-burned-patient
#12
Guillermo Foncerrada, Derek M Culnan, Karel D Capek, Sagrario González-Trejo, Janos Cambiaso-Daniel, Lee C Woodson, David N Herndon, Celeste C Finnerty, Jong O Lee
Inhalation injury causes a heterogeneous cascade of insults that increase morbidity and mortality among the burn population. Despite major advancements in burn care for the past several decades, there remains a significant burden of disease attributable to inhalation injury. For this reason, effort has been devoted to finding new therapeutic approaches to improve outcomes for patients who sustain inhalation injuries.The three major injury classes are the following: supraglottic, subglottic, and systemic. Treatment options for these three subtypes differ based on the pathophysiologic changes that each one elicits...
March 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29449035/usage-of-density-analysis-based-on-micro-ct-for-studying-lung-injury-associated-with-burn-blast-combined-injury
#13
Yang Chang, Dong-Hai Zhang, Quan Hu, Ling-Ying Liu, Yong-Hui Yu, Jia-Ke Chai
BACKGROUND: Burn-blast combined injury is a kind of injury caused by heat and blast at the same time. The lung injury after burn-blast combined injuries is of primary importance, and investigation of lung injury is needed in the clinical care of patients. Computed tomography (CT) is one of the standard tools used to observe the anatomical basis and pathophysiology of acute lung injury. METHODS: We applied a method of fast 3D (three-dimensional) reconstruction to calculate the density value of the lung injury by CT analysis...
February 12, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29430564/sensory-symptom-profiles-differ-between-trigeminal-and-thoracolumbar-postherpetic-neuralgia
#14
Stefanie Rehm, Moritz Groβkopf, Maria Kabelitz, Thomas Keller, Rainer Freynhagen, Thomas R Tölle, Ralf Baron
Introduction: Animal experimental evidence suggests that mechanisms of pain generation and response to treatment differ between neuropathic pain in the cephalic and the extracephalic innervation territories. Objectives: The objective of the study was to examine whether in humans an identical peripheral painful neuropathy is associated with different pain qualities and sensory abnormalities in the face as compared with the thoracic region. Methods: We retrospectively analysed epidemiological and clinical data of 639 patients with postherpetic neuralgia (PHN) in the face and at the trunk who were collected within a cross-sectional cohort survey and compared the respective sensory symptom profiles captured with the painDETECT questionnaire...
January 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29408836/pathophysiological-response-to-burn-injury-in-adults
#15
Mile Stanojcic, Abdikarim Abdullahi, Sarah Rehou, Alexandra Parousis, Marc G Jeschke
OBJECTIVE: The aim of this study was to compare the hypermetabolic, and inflammatory trajectories in burned adults to gain insight into the pathophysiological alterations and outcomes after injury. SUMMARY OF BACKGROUND DATA: Burn injury leads to a complex response that is associated with hypermetabolism, morbidity, and mortality. The underlying pathophysiology and the correlations between humoral changes and organ function have not been well delineated in adult burn patients...
March 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29357133/pathophysiologic-mechanisms-and-current-treatments-for-cutaneous-sequelae-of-burn-wounds
#16
Caroline Hall, Carolyn Hardin, Christopher J Corkins, Alisha Z Jiwani, John Fletcher, Anders Carlsson, Rodney Chan
Burn injuries are a pervasive clinical problem. Extensive thermal trauma can be life-threatening or result in long-lasting complications, generating a significant impact on quality of life for patients as well as a cost burden to the healthcare system. The importance of addressing global or systemic issues such as resuscitation and management of inhalation injuries is not disputed but is beyond the scope of this review, which focuses on cutaneous pathophysiologic mechanisms for current treatments, both in the acute and long-term settings...
December 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/29340540/toxic-epidermal-necrolysis-a-paradigm-of-critical-illness
#17
Alfonso Estrella-Alonso, José Antonio Aramburu, Mercedes Yolanda González-Ruiz, Lucía Cachafeiro, Manuel Sánchez Sánchez, José A Lorente
Toxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolysis is approximately 30%. The pathophysiology of toxic epidermal necrolysis is similar in many respects to that of superficial skin burns. Mucosal involvement of the ocular and genital epithelium is associated with serious sequelae if the condition is not treated early...
October 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29287057/early-diagnosis-using-canonical-discriminant-analysis-of-innate-immune-receptor-gene-expression-profiles-in-a-murine-infectious-or-sterile-systemic-inflammation-model
#18
Goro Tajima, Ayako Tokunaga, Takahiro Umehara, Kazuya Ikematsu, Junya Miyamoto, Shuntaro Sato, Osamu Tasaki
BACKGROUND: Infection in patients with systemic inflammation is difficult to diagnose with a single biomarker. We aimed to clarify the time course of change in the gene expression profile of innate immune receptors in infectious or sterile inflammation and to establish an early diagnostic method using canonical discriminant analysis (CDA) of the gene expression profile. METHODS: To compare infectious and sterile inflammation, we used cecal ligation and puncture (CLP) and 20% full-thickness burn injury (Burn) models...
April 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29232903/pediatric-thermal-burns-and-treatment-a-review-of-progress-and-future-prospects
#19
REVIEW
Elton Mathias, Madhu Srinivas Murthy
Burn injuries are a devastating critical care problem. In children, burns continue to be a major epidemiologic problem around the globe resulting in significant morbidity and death. Apparently, treating these burn injuries in children and adults remains similar, but there are significant physiological and psychological differences. The dermal layer of the skin is generally thinner in neonates, infants, and children than in adults. Enhanced evaporative loss and need for isotonic fluids increases the risk of hypothermia in the pediatric population...
December 11, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29226160/the-significance-of-changes-in-platelet-concentration-during-the-early-phase-after-severe-burn-injury-in-a-chinese-mass-casualty
#20
Beiming Shou, Junqiang Li, Chenqi Tang, Qian Tan, Dongfeng Zheng, Binwei Sun, Lanjun Nie, Hongwei Zhang, Yanan Jiang, Chunming Wang, Yanwen Wu
Background: Changes in platelet concentration are common in severe burn patients. Platelets play a key role in the course of disease. This study aims to explore the significance of platelet concentration during the course of the disease in victims of a mass burn casualty. Methods: A total of 180 patients were involved in the "8.2" Kunshan explosion accident in China. The examined data included age, gender, total burn area (% TBSA), third-degree burn area (% TBSA), and platelet concentration within the first 5 days after the burn injury...
2017: Burns and trauma
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