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https://www.readbyqxmd.com/read/29074941/orofacial-pain-an-update-on-diagnosis-and-management
#1
S Ghurye, R McMillan
The diagnosis and management of orofacial pain may be challenging due to complex histories, pathophysiology and associated psychosocial co-morbidities such as depression and anxiety. Neuropathic facial pain conditions such as burning mouth syndrome (BMS), persistent idiopathic facial pain (PIFP), atypical odontalgia (AO) and trigeminal neuralgia (TN) require early recognition by primary care clinicians and referral to secondary care. Acute pain-related temporomandibular disorder (TMD) may be managed in the primary care setting, with identification of those at risk of developing chronic TMD receiving an early referral to secondary care...
December 2017: British Dental Journal
https://www.readbyqxmd.com/read/29056027/-differential-expression-of-micrornas-in-serum-of-severe-burn-patients-and-analysis-of-the-signaling-pathway-at-early-stage
#2
S Wang, Q F Ruan, W G Xie, L Chen, M J Jiang, J J Ruan, Z Q Ye
Objective: To explore differential expression of microRNAs in serum of patients with severe burn and analysis of the signaling pathway at early stage. Methods: In this study, we included three healthy adult volunteers and three patients with severe burn, conforming to the inclusion criteria and hospitalized in Tongren Hospital of Wuhan University & Wuhan Third Hospital in July 2015. Venous whole blood of 6 mL of each burn patient and healthy volunteer was collected at 24 to 48 h post injury of burn patients...
October 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29036469/burn-pain-a-systematic-and-critical-review-of-epidemiology-pathophysiology-and-treatment
#3
Michael Morgan, Jennifer R Deuis, Majbrit Frøsig-Jørgensen, Richard J Lewis, Peter J Cabot, Paul D Gray, Irina Vetter
Objective: This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain. Methods: A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the database Medline, and all relevant articles were systemically reviewed. In addition, a critical review was performed on the pathophysiology of burn pain and animal models of burn pain. Results: The search on the epidemiology of burn injury yielded a total of 163 publications of interest, 72 of which fit the inclusion/exclusion criteria, with no publications providing epidemiological data on burn injury pain management outcomes...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036361/chronic-pain-and-neuropathy-following-adjuvant-chemotherapy
#4
Lise Ventzel, Caspar S Madsen, Páll Karlsson, Hatice Tankisi, Baris Isak, Anders Fuglsang-Frederiksen, Anders B Jensen, Anni R Jensen, Troels S Jensen, Nanna B Finnerup
Objective: To determine symptoms and characteristics of chronic sensory neuropathy in patients treated with oxaliplatin and docetaxel, including patterns of somatosensory abnormalities, pain descriptors, and psychological functioning. Design: A retrospective cross-sectional study. Setting: A chronic pain research center. Subjects: Thirty-eight patients with chronic peripheral pain and/or dysesthesia following chemotherapy...
September 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29021720/burn-injury-review-of-pathophysiology-and-therapeutic-modalities-in-major-burns
#5
I Kaddoura, G Abu-Sittah, A Ibrahim, R Karamanoukian, N Papazian
Despite a considerable decrease in their incidence worldwide, burn injuries remain one of the commonest forms of trauma and account for a weighty proportion of trauma cases in health-care emergencies around the globe. Although the latest data reveal a substantial decline in burn-related mortality and hospital admissions in the US over the past three decades, severe thermal injuries continue to trigger devastating morbidity and significant mortality while their management remains a dynamic challenge for the entire medical and paramedical community...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28964882/the-effects-of-major-burn-related-pathophysiological-changes-on-the-pharmacokinetics-and-pharmacodynamics-of-drug-use-an-appraisal-utilizing-antibiotics
#6
Andrew A Udy, Jason A Roberts, Jeffrey Lipman, Stijn Blot
Patients suffering major burn injury represent a unique population of critically ill patients. Widespread skin and tissue damage causes release of systemic inflammatory mediators that promote endothelial leak, extravascular fluid shifts, and cardiovascular derangement. This phase is characterized by relative intra-vascular hypovolaemia and poor peripheral perfusion. Large volume intravenous fluid resuscitation is generally required. The patients' clinical course is then typically complicated by ongoing inflammation, protein catabolism, and marked haemodynamic perturbation...
September 28, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28954102/sensitive-skin-review-of-an-ascending-concept
#7
REVIEW
Ida Duarte, Jéssica Eleonora P S Silveira, Mariana de Figueiredo Silva Hafner, Raquel Toyota, Debora Midori M Pedroso
Sensitive skin is a condition characterized by stinging, burning and itching sensations. The diagnosis, pathophysiology and treatment of sensitive skin are still under discussion. In the last years, studies on its epidemiology have been performed, showing a high prevalence and impact on quality of life. Brazilian population was also considered in these studies. Cosmetics, climate changes and skin barrier impairment are the main factors that contribute for skin hyperreactivity. New studies are trying to bring new knowledge about the theme...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28948056/could-hallucinogens-induce-permanent-pupillary-changes-in-ab-users-a-case-report-from-new-zealand
#8
Ahmed Al-Imam
An eighteen-year-old female patient of the Caucasian ethnicity from Australasia presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when she is outdoors due to oversensitivity to sunlight. However, her pupillary reaction to light (pupillary light reflex) was intact. The patient is a known user of psychedelic substances (entheogens) including LSD, NBOMe, psilocybin, and DMT. The condition affects both eyes to the same extent. Thorough medical, neurological, and radiological examinations, including an EEG and an MRI of the head and neck region, were completely normal...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28947688/-pathophysiology-and-treatment-of-orofacial-pain
#9
Masamichi Shinoda, Noboru Noma
"Pain" is one of body defense mechanisms and crucial for the life support. However, orofacial pain such as myofascial pain syndrome, burning mouth syndrome and trigeminal neuralgia plays no part in body defense mechanisms and requires therapeutic intervention. Recent studies have indicated that plastic changes in the activities of trigeminal neurons, satellite glial cells in trigeminal ganglion, secondary neurons, microglia and astrocytes in trigeminal spinal subnucleus following orofacial inflammation and trigeminal nerve injury are responsible for orofacial pain mechanisms...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28916026/a-diagnostic-and-therapeutic-approach-to-primary-burning-mouth-syndrome
#10
Siamak Moghadam-Kia, Nasim Fazel
Primary burning mouth syndrome (BMS) is an oral mucosal disorder that is characterized by a chronic and often debilitating intraoral burning sensation for which no localized or systemic cause can be found. BMS most commonly affects postmenopausal women. The pathophysiology of primary BMS is not well understood. Diagnosing BMS can prove to be challenging. BMS patients can also pose a therapeutic challenge to clinicians who are consulted to evaluate these patients. Most commonly used therapies include tricyclic antidepressants, α-lipoic acid, clonazepam, and cognitive-behavioral therapy...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28888299/principles-of-burn-pain-management
#11
REVIEW
Dominika Lipowska James, Maryam Jowza
This article describes pathophysiology of burn injury-related pain and the basic principles of burn pain management. The focus is on concepts of perioperative and periprocedural pain management with extensive discussion of opioid-based analgesia, including patient-controlled analgesia, challenges of effective opioid therapy in opioid-tolerant patients, and opioid-induced hyperalgesia. The principles of multimodal pain management are discussed, including the importance of psychological counseling, perioperative interventional pain procedures, and alternative pain management options...
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28887905/past-present-and-future-of-parkinson-s-disease-a-special-essay-on-the-200th-anniversary-of-the-shaking-palsy
#12
REVIEW
J A Obeso, M Stamelou, C G Goetz, W Poewe, A E Lang, D Weintraub, D Burn, G M Halliday, E Bezard, S Przedborski, S Lehericy, D J Brooks, J C Rothwell, M Hallett, M R DeLong, C Marras, C M Tanner, G W Ross, J W Langston, C Klein, V Bonifati, J Jankovic, A M Lozano, G Deuschl, H Bergman, E Tolosa, M Rodriguez-Violante, S Fahn, R B Postuma, D Berg, K Marek, D G Standaert, D J Surmeier, C W Olanow, J H Kordower, P Calabresi, A H V Schapira, A J Stoessl
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority...
September 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28859662/chronic-pain-in-gaucher-disease-skeletal-or-neuropathic-origin
#13
Grazia Devigili, Michele De Filippo, Giovanni Ciana, Andrea Dardis, Christian Lettieri, Sara Rinaldo, Daniela Macor, Alessandro Moro, Roberto Eleopra, Bruno Bembi
BACKGOUND: Pain is one of the most disabling symptoms of Gaucher disease. It is referred by the majority of Gaucher patients and often persists despite long-term enzyme replacement treatment. It has been mainly considered as nociceptive pain secondary to skeletal involvement but it is described even in the absence of bone disease without a clear explanation. In the last years an increasing number of reports have described the presence of neurological manifestation in Gaucher type 1 patients, including subclinical large fibre neuropathy...
August 31, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28777823/two-new-risk-factors-for-heterotopic-ossification-development-after-severe-burns
#14
Laurent Thefenne, Gratiane de Brier, Thomas Leclerc, Claire Jourdan, Claire Nicolas, Stéphanie Truffaut, Eric Lapeyre, Francois Genet
OBJECTIVES: Life after severe burns is conditioned by the remaining sequelae. The pathophysiology and risk factors of Heterotopic Ossification (HO) after burns are still poorly understood. The aim of this study was to determine: 1) the incidence of HO after burns and 2) the risk factors associated with HO development, in a large retrospective study. METHODS: A case-control study of patients admitted to the burns intensive care unit of Percy Hospital, Paris, from the 1st January 2009 to the 31st December 2013 and then admitted to one of three centres specialised in the rehabilitation of patients with burns...
2017: PloS One
https://www.readbyqxmd.com/read/28730896/cannabinoid-hyperemesis-syndrome-potential-mechanisms-for-the-benefit-of-capsaicin-and-hot-water-hydrotherapy-in-treatment
#15
John R Richards, Jeff M Lapoint, Guillermo Burillo-Putze
INTRODUCTION: Cannabinoid hyperemesis syndrome is a clinical disorder that has become more prevalent with increasing use of cannabis and synthetic cannabinoids, and which is difficult to treat. Standard antiemetics commonly fail to alleviate the severe nausea and vomiting characteristic of the syndrome. Curiously, cannabinoid hyperemesis syndrome patients often report dramatic relief of symptoms with hot showers and baths, and topical capsaicin. OBJECTIVES: In this review, we detail the pharmacokinetics and pharmacodynamics of capsaicin and explore possible mechanisms for its beneficial effect, including activation of transient receptor potential vanilloid 1 and neurohumoral regulation...
July 21, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28727221/scar-formation-following-excisional-and-burn-injuries-in-a-red-duroc-pig-model
#16
Britani N Blackstone, Jayne Y Kim, Kevin L McFarland, Chandan K Sen, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Scar research is challenging because rodents do not naturally form excessive scars, and burn depth, size, and location cannot be controlled in human longitudinal studies. The female, red Duroc pig model has been shown to form robust scars with biological and anatomical similarities to human hypertrophic scars. To more closely mimic the mode of injury, recreate the complex chemical milieu of the burn wound environment and enhance scar development, an animal model of excessive burn-induced scarring was developed and compared with the more commonly used model, which involves excisional wounds created via dermatome...
August 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28722143/breast-cancer-stem-cells-as-last-soldiers-eluding-therapeutic-burn-a-hard-nut-to-crack
#17
REVIEW
Pritish Nilendu, Ajay Kumar, Azad Kumar, Jayanta K Pal, Nilesh Kumar Sharma
Cancer stem cells (CSCs) are found in many cancer types, including breast carcinoma. Breast cancer stem cells (BCSCs) are considered as seed of cancer formation and they are associated with metastasis and genotoxic drug resistance. Several studies highlighted the presence of BCSCs in tumor microenvironment and they are accentuated with several carcinoma events including metastasis and resistance to genotoxic drugs and they also rebound after genotoxic burn. Stemness properties of a small population of cells in carcinoma have provided clues regarding the role of tumor microenvironment in tumor pathophysiology...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28700414/evaluation-of-gut-blood-barrier-dysfunction-in-various-models-of-trauma-hemorrhagic-shock-and-burn-injury
#18
Lisa Wrba, Annette Palmer, Christian Karl Braun, Markus Huber-Lang
No abstract text is available yet for this article.
November 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28697015/the-p50-research-center-in-perioperative-sciences-how-the-investment-by-the-national-institute-of-general-medical-sciences-in-team-science-has-reduced-postburn-mortality
#19
Celeste C Finnerty, Karel D Capek, Charles Voigt, Gabriel Hundeshagen, Janos Cambiaso-Daniel, Craig Porter, Linda E Sousse, Amina El Ayadi, Ramon Zapata-Sirvent, Ashley N Guillory, Oscar E Suman, David N Herndon
Since the inception of the P50 Research Center in Injury and Peri-operative Sciences (RCIPS) funding mechanism, the National Institute of General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in the early 1970s, prior to the inception of the P50 RCIPS program, are now routinely survived as a result of the P50-funded research. The advances in clinical care that led to the reduction in postburn death were made by optimizing resuscitation, incorporating early excision and grafting, bolstering acute care including support for inhalation injury, modulating the hypermetabolic response, augmenting the immune response, incorporating aerobic exercise, and developing antiscarring strategies...
September 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28645160/chronic-pseudomonas-aeruginosa-biofilm-infection-impairs-murine-s100a8-a9-and-neutrophil-effector-cytokines-implications-for-delayed-wound-closure
#20
Hannah Trøstrup, Christian Johann Lerche, Lars Jackie Christophersen, Kim Thomsen, Peter Østrup Jensen, Hans Petter Hougen, Niels Høiby, Claus Moser
The impact of Pseudomonas aeruginosa biofilm infections in chronic wounds and clinical implication for healing is receiving increased attention. However, the pathophysiology of host/pathogen interplay is not fully understood. By further revealing the mechanisms, necessary new treatment strategies may be identified. Since the background for chronic wounds is diverse, representative animal models are important. We assessed host response and spontaneous wound closure in the relatively resistant C3H/HeN and the susceptible BALB/c mouse strain...
September 29, 2017: Pathogens and Disease
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