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Biomaterial vaccine

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https://www.readbyqxmd.com/read/27819009/chitin-and-chitosan-production-and-application-of-versatile-biomedical-nanomaterials
#1
Daniel Elieh-Ali-Komi, Michael R Hamblin
Chitin is the most abundant aminopolysaccharide polymer occurring in nature, and is the building material that gives strength to the exoskeletons of crustaceans, insects, and the cell walls of fungi. Through enzymatic or chemical deacetylation, chitin can be converted to its most well-known derivative, chitosan. The main natural sources of chitin are shrimp and crab shells, which are an abundant byproduct of the food-processing industry, that provides large quantities of this biopolymer to be used in biomedical applications...
March 2016: International Journal of Advanced Research
https://www.readbyqxmd.com/read/27816821/enhanced-antitumor-immunity-by-targeting-dendritic-cells-with-tumor-cell-lysate-loaded-chitosan-nanoparticles-vaccine
#2
Gao-Na Shi, Chuang-Nian Zhang, Rong Xu, Jin-Feng Niu, Hui-Juan Song, Xiu-Yuan Zhang, Wei-Wei Wang, Yan-Ming Wang, Chen Li, Xiao-Qing Wei, De-Ling Kong
Whole tumor cell lysates (TCL) have been implemented as tumor antigens for cancer vaccine development, although clinical outcomes of TCL-based antitumor immunotherapy remain unsatisfactory. In order to improve the efficacy of TCL-based vaccines, biomaterials have been employed to enhance antigen delivery and presentation. Here, we have developed chitosan nanoparticles (CTS NPs) with surface mannose (Man) moieties for specific dendritic cells (DCs) targeting (Man-CTS NPs). The Man-CTS NPs were then loaded with TCL generated from B16 melanoma cells (Man-CTS-TCL NPs) for in vitro and in vivo assessment...
October 29, 2016: Biomaterials
https://www.readbyqxmd.com/read/27800166/an-assessment-of-the-future-impact-of-alternative-technologies-on-antibiotics-markets
#3
Ejike Nwokoro, Ross Leach, Christine Årdal, Enrico Baraldi, Kellie Ryan, Jens Plahte
BACKGROUND: The increasing threat of antimicrobial resistance combined with the paucity of new classes of antibiotics represents a serious public health challenge. New treatment technologies could, in theory, have a significant impact on the future use of traditional antibiotics, be it by facilitating rational and responsible use or by product substitution in the existing antibiotics markets, including by reducing the incidence of bacterial infections through preventative approaches. The aim of this paper is to assess the potential of alternative technologies in reducing clinical use of and demand for antibiotics, and to briefly indicate which segments of the antibiotics market that might be impacted by these technologies...
2016: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/27716780/complex-particulate-biomaterials-as-immunostimulant-delivery-platforms
#4
Débora Torrealba, Joaquin Seras-Franzoso, Uwe Mamat, Kathleen Wilke, Antonio Villaverde, Nerea Roher, Elena Garcia-Fruitós
The control of infectious diseases is a major current challenge in intensive aquaculture. Most commercial vaccines are based on live attenuated or inactivated pathogens that are usually combined with adjuvants, oil emulsions being as the most widely used for vaccination in aquaculture. Although effective, the use of these oil emulsions is plagued with important side effects. Thus, the development of alternative safer and cost-effective immunostimulants and adjuvants is highly desirable. Here we have explored the capacity of inclusion bodies produced in bacteria to immunostimulate and protect fish against bacterial infections...
2016: PloS One
https://www.readbyqxmd.com/read/27680575/switching-the-immunogenicity-of-peptide-assemblies-using-surface-properties
#5
Yi Wen, Amelia Waltman, Huifang Han, Joel H Collier
Biomaterials created from supramolecular peptides, proteins, and their derivatives have been receiving increasing interest for both immunological applications, such as vaccines and immunotherapies, as well as ostensibly nonimmunological applications, such as therapeutic delivery or tissue engineering. However, simple rules for either maximizing immunogenicity or abolishing it have yet to be elucidated, even though immunogenicity is a prime consideration for the design of any supramolecular biomaterial intended for use in vivo...
October 3, 2016: ACS Nano
https://www.readbyqxmd.com/read/27597649/%C3%AE-helical-coiled-coil-peptide-materials-for-biomedical-applications
#6
Yaoying Wu, Joel H Collier
Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combinations of these...
September 6, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27567213/impact-of-dose-route-and-composition-on-the-immunogenicity-of-immune-polyelectrolyte-multilayers-delivered-on-gold-templates
#7
Peipei Zhang, James I Andorko, Christopher M Jewell
Biomaterial vaccines offer new capabilities that can be exploited for both infectious disease and cancer. We recently developed a novel vaccine platform based on self-assembly of immune signals into immune polyelectrolyte multilayers (iPEMs). These iPEM vaccines are electrostatically assembled from peptide antigens and nucleic acid-based toll-like receptor agonists (TLRas) that serve as molecular adjuvants. Gold nanoparticles (AuNPs) coated with iPEMs stimulate effector cytokine secretion in vitro and expand antigen-specific T cells in mice...
August 27, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27547269/targeted-programming-of-the-lymph-node-environment-causes-evolution-of-local-and-systemic-immunity
#8
James I Andorko, Joshua M Gammon, Lisa H Tostanoski, Qin Zeng, Christopher M Jewell
Biomaterial vaccines offer cargo protection, targeting, and co-delivery of signals to immune organs such as lymph nodes (LNs), tissues that coordinate adaptive immunity. Understanding how individual vaccine components impact immune response has been difficult owing to the systemic nature of delivery. Direct intra-lymph node (i.LN.) injection offers a unique opportunity to dissect how the doses, kinetics, and combinations of signals reaching LNs influence the LN environment. Here, i.LN. injection was used as a tool to study the local and systemic responses to vaccines comprised of soluble antigen and degradable polymer particles encapsulating toll-like receptor agonists as adjuvants...
2016: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/27494238/advances-and-potential-applications-of-chitosan-nanoparticles-as-a-delivery-carrier-in-the-vaccine
#9
Kai Zhao, Dan Li, Hong Kang, Yu Guang Rong, Xiaohua Wang, Zheng Jin
Chitosan, a natural polysaccharide derived from chitin, has been widely applied in drug delivery, tissue regeneration, wound healing, blood coagulation and immunostimulation due to its well-known biocompatibility and biodegradability. Chitosan has become a valuable vaccine adjuvant and delivery carrier, which have attracted increasing attention for its applications. Currently chitosan nanoparticles have been developed as adjuvant or immunomodulators and drug carrier. Here we reviewed chitosan nanoparticles, which is a promising biomaterial as vaccine adjuvant and delivery carrier, including characteristics, preparation methods and applications, or even its limitations...
August 4, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27494157/advances-and-potential-applications-of-chitosan-nanoparticles-as-a-delivery-carrier-for-the-mucosal-immunity-of-vaccine
#10
Dan Li, Dongwei Fu, Hong Kang, Guangyu Rong, Zheng Jin, Xiaohua Wang, Kai Zhao
Chitosan, a natural polysaccharide derived from chitin, has been widely applied in drug delivery, tissue regeneration, wound healing, blood coagulation and immunostimulation due to its well-known biocompatibility and biodegradability. Chitosan has become a valuable vaccine adjuvant and delivery carrier, which have attracted increasing attention for its applications. Currently chitosan nanoparticles have been developed as adjuvant or immunomodulators and drug carrier. Here we reviewed chitosan nanoparticles, which is a promising biomaterial as vaccine adjuvant and delivery carrier, including characteristics, preparation methods and applications, or even its limitations...
August 4, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27419235/in-situ-pneumococcal-vaccine-production-and-delivery-through-a-hybrid-biological-biomaterial-vector
#11
Yi Li, Marie Beitelshees, Lei Fang, Andrew Hill, Mahmoud Kamal Ahmadi, Mingfu Chen, Bruce A Davidson, Paul Knight, Randall J Smith, Stelios T Andreadis, Anders P Hakansson, Charles H Jones, Blaine A Pfeifer
The type and potency of an immune response provoked during vaccination will determine ultimate success in disease prevention. The basis for this response will be the design and implementation of antigen presentation to the immune system. Whereas direct antigen administration will elicit some form of immunological response, a more sophisticated approach would couple the antigen of interest to a vector capable of broad delivery formats and designed for heightened response. New antigens associated with pneumococcal disease virulence were used to test the delivery and adjuvant capabilities of a hybrid biological-biomaterial vector consisting of a bacterial core electrostatically coated with a cationic polymer...
July 2016: Science Advances
https://www.readbyqxmd.com/read/27380137/assembly-and-immunological-processing-of-polyelectrolyte-multilayers-composed-of-antigens-and-adjuvants
#12
Yu-Chieh Chiu, Joshua M Gammon, James I Andorko, Lisa H Tostanoski, Christopher M Jewell
While biomaterials provide a platform to control the delivery of vaccines, the recently discovered intrinsic inflammatory characteristics of many polymeric carriers can also complicate rational design because the carrier itself can alter the response to other vaccine components. To address this challenge, we recently developed immune-polyelectrolyte multilayer (iPEMs) capsules electrostatically assembled entirely from peptide antigen and molecular adjuvants. Here, we use iPEMs built from SIINFEKL model antigen and polyIC, a stimulatory toll-like receptor agonist, to investigate the impact of pH on iPEM assembly, the processing and interactions of each iPEM component with primary immune cells, and the role of these interactions during antigen-specific T cell responses in coculture and mice...
July 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27187416/effect-of-chitosan-properties-on-immunoreactivity
#13
Sruthi Ravindranathan, Bhanu Prasanth Koppolu, Sean G Smith, David A Zaharoff
Chitosan is a widely investigated biopolymer in drug and gene delivery, tissue engineering and vaccine development. However, the immune response to chitosan is not clearly understood due to contradicting results in literature regarding its immunoreactivity. Thus, in this study, we analyzed effects of various biochemical properties, namely degree of deacetylation (DDA), viscosity/polymer length and endotoxin levels, on immune responses by antigen presenting cells (APCs). Chitosan solutions from various sources were treated with mouse and human APCs (macrophages and/or dendritic cells) and the amount of tumor necrosis factor-α (TNF-α) released by the cells was used as an indicator of immunoreactivity...
2016: Marine Drugs
https://www.readbyqxmd.com/read/27133472/poly-gamma-glutamic-acid-from-bacillus-subtilis-upregulates-pro-inflammatory-cytokines-while-inhibiting-nlrp3-nlrc4-and-aim2-inflammasome-activation
#14
Huijeong Ahn, Seung Goo Kang, Sung-Il Yoon, Pyeung-Hyeun Kim, Doo Kim, Geun-Shik Lee
Poly-gamma-glutamic acid (γ-PGA) is a natural, edible and non-toxic polymer synthesized by Bacillus subtilis and is suggested as a safe biomaterial for the use in hydrogels and vaccine adjuvants. However, the effect of γ-PGA on inflammasome activation has not yet been studied in macrophages. Inflammasomes, which are intracellular multi-protein complexes, promote acute and chronic inflammation via interleukin-1β or interleukin-18 maturation, and they are known targets for metabolic syndromes and cancer. In this study, we observed that γ-PGA attenuated NLRP3, NLRC4 and AIM2 inflammasome activation, whereas it upregulated pro-inflammatory cytokine expression in human and murine macrophages...
May 2, 2016: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/27100566/self-assembly-protein-nanogels-for-safer-cancer-immunotherapy
#15
Alberto Purwada, Ye F Tian, Weishan Huang, Kathleen M Rohrbach, Simrita Deol, Avery August, Ankur Singh
Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches.
June 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27048557/micro-and-nanoparticulates-for-dna-vaccine-delivery
#16
Eric Farris, Deborah M Brown, Amanda E Ramer-Tait, Angela K Pannier
DNA vaccination has emerged as a promising alternative to traditional protein-based vaccines for the induction of protective immune responses. DNA vaccines offer several advantages over traditional vaccines, including increased stability, rapid and inexpensive production, and flexibility to produce vaccines for a wide variety of infectious diseases. However, the immunogenicity of DNA vaccines delivered as naked plasmid DNA is often weak due to degradation of the DNA by nucleases and inefficient delivery to immune cells...
May 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27047675/recent-advances-of-biomaterials-in-biotherapy
#17
REVIEW
Ling Li, Zhi-Yao He, Xia-Wei Wei, Yu-Quan Wei
Biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs, which include gene therapy, immunotherapy (vaccines and antibodies), bone marrow transplantation and stem-cell therapy. In recent years, numerous biomaterials have emerged and were utilized in the field of biotherapy due to their biocompatibility and biodegradability. Generally, biomaterials can be classified into natural or synthetic polymers according to their source, both of which have attracted much attention...
June 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/27038091/particulate-delivery-systems-for-vaccination-against-bioterrorism-agents-and-emerging-infectious-pathogens
#18
REVIEW
Yuchen Fan, James J Moon
Bioterrorism agents that can be easily transmitted with high mortality rates and cause debilitating diseases pose major threats to national security and public health. The recent Ebola virus outbreak in West Africa and ongoing Zika virus outbreak in Brazil, now spreading throughout Latin America, are case examples of emerging infectious pathogens that have incited widespread fear and economic and social disruption on a global scale. Prophylactic vaccines would provide effective countermeasures against infectious pathogens and biological warfare agents...
April 1, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/26964520/artificial-supramolecular-protein-assemblies-as-functional-high-order-protein-scaffolds
#19
Yu-Na Kim, Yongwon Jung
Supramolecular assemblies of protein building blocks potentially offer unique biomaterials with unmatched functionalities as well as atomic level structural accuracy. An increasing number of assembling strategies have been reported for the fabrication of diverse artificial protein assemblies, ranging from rather heterogeneous protein oligomers to computationally designed discrete protein architectures. In this perspective, we discuss these artificial protein supramolecules in terms of their use as highly potent high-order protein scaffolds that can display various functional proteins with precise structural and valency control...
June 28, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/26956913/characterising-the-material-properties-at-the-interface-between-skin-and-a-skin-vaccination-microprojection-device
#20
Michael L Crichton, Cameron Archer-Jones, Stefano Meliga, Grant Edwards, Darren Martin, Han Huang, Mark A F Kendall
UNLABELLED: The rapid emergence of micro-devices for biomedical applications over the past two decades has introduced new challenges for the materials used in the devices. Devices like microneedles and the Nanopatch, require sufficient strength to puncture skin often with sharp-slender micro-scale profiles, while maintaining mechanical integrity. For these technologies we sought to address two important questions: 1) On the scale at which the device operates, what forces are required to puncture the skin? And 2) What loads can the projections/microneedles withstand prior to failure...
May 2016: Acta Biomaterialia
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