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myer's cocktail

Diogo M Magnani, Thomas F Rogers, Nicholas J Maness, Nathan D Grubaugh, Nathan Beutler, Varian K Bailey, Lucas Gonzalez-Nieto, Martin J Gutman, Núria Pedreño-Lopez, Jaclyn M Kwal, Michael J Ricciardi, Tereance A Myers, Justin G Julander, Rudolf P Bohm, Margaret H Gilbert, Faith Schiro, Pyone P Aye, Robert V Blair, Mauricio A Martins, Kathrine P Falkenstein, Amitinder Kaur, Christine L Curry, Esper G Kallas, Ronald C Desrosiers, Pascal J Goldschmidt-Clermont, Stephen S Whitehead, Kristian G Andersen, Myrna C Bonaldo, Andrew A Lackner, Antonito T Panganiban, Dennis R Burton, David I Watkins
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia...
April 24, 2018: Nature Communications
Megan I Myers, Joseph G Sebranek, James S Dickson, Angela M Shaw, Rodrigo Tarté, Kristin R Adams, Steve Neibuhr
Increased popularity of natural and organic processed meats can be attributed to the growing consumer demand for preservative-free foods, including processed meats. To meet this consumer demand, meat processors have begun using celery juice concentrate in place of sodium nitrite to create products labeled as no-nitrate or no-nitrite-added meat products while maintaining the characteristics unique to conventionally cured processed meats. Because of flavor limitations, natural cures with celery concentrate typically provide lower ingoing nitrite concentrations for ready-to-eat processed meats than do conventional cures, which could allow for increased growth of pathogens, such as Clostridium perfringens, during cooked product cooling such as that required by the U...
January 2016: Journal of Food Protection
Andrea M Keane-Myers, Matt Bell, Drew Hannaman, Mark Albrecht
Effective multi-agent/multivalent vaccines that confer protection against more than one disease are highly desirable to the patient and to health-care professionals. Electroporation of DNA vaccines, whereby tissues injected with DNA are subjected to localized electrical currents, is an ideal platform technology that achieves protective immune responses to multivalent vaccination. Here, we describe an electroporation-based immunization technique capable of administering a cocktail of DNA vaccinations in vivo...
2014: Methods in Molecular Biology
Mark T Albrecht, Brian D Livingston, John T Pesce, Matt G Bell, Drew Hannaman, Andrea M Keane-Myers
Electroporation of DNA vaccines represents a platform technology well positioned for the development of multivalent biodefense vaccines. To evaluate this hypothesis, three vaccine constructs were produced using codon-optimized genes encoding Bacillus anthracis Protective Antigen (PA), and the Yersinia pestis genes LcrV and F1, cloned into pVAX1. A/J mice were immunized on a prime-boost schedule with these constructs using the electroporation-based TriGrid Delivery System. Immunization with the individual pDNA vaccines elicited higher levels of antigen-specific IgG than when used in combination...
July 6, 2012: Vaccine
Ather Ali, Valentine Yanchou Njike, Veronika Northrup, Alyse B Sabina, Anna-Leila Williams, Lauren S Liberti, Adam I Perlman, Harry Adelson, David L Katz
OBJECTIVES: Intravenous micronutrient therapy (IVMT), and specifically the Myers' Cocktail, is a popular approach for treating fibromyalgia syndrome (FMS) among complementary and alternative medicine practitioners, but its efficacy is uncertain. This trial assessed the feasibility, safety, and provided insights into the efficacy of this therapy. DESIGN: This was a randomized, double-blind, placebo-controlled pilot study. LOCATIONS: The study locations were an academic research center, teaching hospital, and affiliated Integrative Medicine Center in Derby, CT...
March 2009: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
E Claire Dees, Karen P McKinnon, Jennifer J Kuhns, Kathryn A Chwastiak, Scotty Sparks, Mary Myers, Edward J Collins, Jeffrey A Frelinger, Henrik Van Deventer, Frances Collichio, Lisa A Carey, Mark E Brecher, Mark Graham, H Shelton Earp, Jonathan S Serody
PURPOSE: Immunotherapy using either dendritic cells (DCs) or expanded cytotoxic T cells (CTLs) has received increased interest in the treatment of specific malignancies including metastatic breast cancer (MBC). DCs can be generated ex vivo from monocytes or CD34+ precursors. The ability to expand and safely administer CD34-derived DCs in patients with MBC that have received prior cytotoxic chemotherapy has not been evaluated. METHODS: We enrolled ten patients with MBC that had received prior chemotherapy for the treatment of metastatic disease on a phase I/II trial designed to test the safety and feasibility of administering ex vivo expanded DCs from CD34+ progenitor cells...
September 2004: Cancer Immunology, Immunotherapy: CII
Alan R Gaby
Building on the work of the late John Myers, MD, the author has used an intravenous vitamin-and-mineral formula for the treatment of a wide range of clinical conditions. The modified "Myers' cocktail," which consists of magnesium, calcium, B vitamins, and vitamin C, has been found to be effective against acute asthma attacks, migraines, fatigue (including chronic fatigue syndrome), fibromyalgia, acute muscle spasm, upper respiratory tract infections, chronic sinusitis, seasonal allergic rhinitis, cardiovascular disease, and other disorders...
October 2002: Alternative Medicine Review: a Journal of Clinical Therapeutic
M J Myers, D E Farrell, K D Howard, J C Kawalek
Constitutive swine enzymes analogous to human/rat cytochrome P450 (CYP) isoforms 1A2, 2A6, 2B1/2/6, 2D6, 2E1, 3A1, and 4A1/3 were detected by Western blot analysis. Swine 2E1 has a molecular weight greater than rat 2E1; swine 2B2 has a molecular weight similar to human 2B6. An induction cocktail containing beta-naphthoflavone, phenobarbital, and dexamethasone induced immunoreactive homologs of 1A1, 1A2, 2B1, 2B2, 3A1, and 3A2. Although the P450 content was increased by induction, there was no difference in the Soret lambda(max)...
June 2001: Drug Metabolism and Disposition: the Biological Fate of Chemicals
D Lonsdale, R J Shamberger, J P Stahl, R Evans
Regardless of clinical diagnosis, many acutely and chronically sick patients benefit from intravenous vitamins and minerals, which are usually administered in multiple infusions before observing obvious benefit. We hypothesized this effect was due to improved cellular energy, and attempted to find laboratory evidence via this study. Two groups of patients, chosen at random, received a single infusion of vitamins and minerals in two different dose schedules. Controls received no treatment. Study subjects were patients who presented specifically for a nutritional therapeutic approach, and although all were treated with multiple infusions, a single infusion was selected at random for this study...
February 1999: Alternative Medicine Review: a Journal of Clinical Therapeutic
E L Kittler, S O Peters, R B Crittenden, M E Debatis, H S Ramshaw, F M Stewart, P J Quesenberry
Using a murine bone marrow transplantation model, we evaluated the long-term engraftment of retrovirally transduced bone marrow cells in nonmyeloablated hosts. Male bone marrow was stimulated in a cocktail of interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor (SCF) for 48 hours, then cocultured on the retroviral producer line MDR18.1 for an additional 24 hours. Functional transduction of hematopoietic progenitors was detected in vitro by reverse transcriptase-polymerase chain reaction (RT-PCR) amplification of multiple drug resistance 1 (MDR1) mRNA from high proliferative potential-colony forming cell (HPP-CFC) colonies...
July 15, 1997: Blood
F M Uckun, S M Azemove, D E Myers, D A Vallera
We evaluated the inhibitory effects of two immunotoxins (IT) synthesized by linking two different anti-CD2 (T, p50) murine monoclonal antibodies (MoAb) to intact ricin (R). Pretreatment with 1000 ng ml-1 35.1-R or OKT 11a-R inhibited PHA-induced T-cell proliferation by 93% and 86%, respectively. At this IT concentration generation of alloreactive cytotoxic T-cells (CTL) was inhibited by more than 99% by either IT. 35.1-R and OKT 11a were minimally toxic to natural killer (NK) effectors or pluripotent bone marrow progenitor cells (CFU-GEMM)...
1986: Leukemia Research
F M Uckun, J H Kersey, D A Vallera, J A Ledbetter, D Weisdorf, D E Myers, R Haake, N K Ramsay
Fourteen patients with high-risk T-lineage acute lymphoblastic leukemia (ALL) in complete remission underwent autologous bone marrow transplantation (BMT) in an attempt to eradicate their residual disease burden. A combined immunochemotherapy protocol using a cocktail of two immunotoxins directed against CD5/Tp67 and CD7/Tp41 T-lineage differentiation antigens in combination with the in vitro active cyclophosphamide congener 4-hydroperoxy-cyclophosphamide (4-HC) was used to purge autografts. Despite high dose pretransplant radiochemotherapy and effective purging of autografts, 9 of 14 patients relapsed at a median of 2...
November 1, 1990: Blood
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