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Moderate traumatic brain injury

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https://www.readbyqxmd.com/read/27909098/reversible-disruption-of-neuronal-mitochondria-by-ischemic-and-traumatic-injury-revealed-by-quantitative-two-photon-imaging-in-the-neocortex-of-anesthetized-mice
#1
Mikhail Kislin, Jeremy Sword, Ioulia V Fomitcheva, Deborah Croom, Evgeny Pryazhnikov, Eero Lihavainen, Dmytro Toptunov, Heikki Rauvala, Andre S Ribeiro, Leonard Khiroug, Sergei A Kirov
: Mitochondria play a variety of functional roles in cortical neurons, from metabolic support and neuroprotection to the release of cytokines that trigger apoptosis. In dendrites, mitochondrial structure is closely linked to their function, and fragmentation (fission) of the normally elongated mitochondria indicates loss of their function under such pathological conditions as stroke and brain trauma. Using in vivo two-photon microscopy in mouse brain, we quantified mitochondrial fragmentation in a full spectrum of cortical injuries ranging from severe to mild...
December 1, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27901414/cognitive-deficits-and-inflammatory-response-resulting-from-mild-to-moderate-traumatic-brain-injury-in-rats-are-exacerbated-by-repeated-pre-exposure-to-an-innate-stress-stimulus
#2
Michaël Ogier, Amor Belmeguenai, Thomas Lieutaud, Béatrice Georges, Sandrine Bouvard, Emilie Carré, Frédéric Canini, Laurent Bezin
Traumatic brain injury (TBI) is common in both military and civilian populations, and often results in neurobehavioral sequelae that impair quality of life in both patients and their family. Although individuals who are chronically exposed to stress are more likely to experience TBI, it is still unknown whether pre-injury stress influences the outcome after TBI. The present study tested whether behavioral and cognitive long-term outcome after TBI in rats is affected by prior exposure to an innate stress stimulus...
November 30, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27898158/multivariate-assessment-of-subjective-and-objective-measures-of-social-and-family-satisfaction-in-veterans-with-history-of-traumatic-brain-injury
#3
Henry J Orff, Chelsea C Hays, Elizabeth W Twamley
Approximately 20% of current-era Veterans have sustained a traumatic brain injury (TBI), which can result in persistent postconcussive symptoms. These symptoms may disrupt family and social functioning. We explored psychiatric, postconcussive, and cognitive factors as correlates of objective functioning and subjective satisfaction in family and social relationships. At entry into a supported employment study, 50 unemployed Veterans with a history of mild to moderate TBI and current cognitive impairment were administered baseline assessments...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27893897/imaging-of-glial-cell-activation-and-white-matter-integrity-in-brains-of-active-and-recently-retired-national-football-league-players
#4
Jennifer M Coughlin, Yuchuan Wang, Il Minn, Nicholas Bienko, Emily B Ambinder, Xin Xu, Matthew E Peters, John W Dougherty, Melin Vranesic, Soo Min Koo, Hye-Hyun Ahn, Merton Lee, Chris Cottrell, Haris I Sair, Akira Sawa, Cynthia A Munro, Christopher J Nowinski, Robert F Dannals, Constantine G Lyketsos, Michael Kassiou, Gwenn Smith, Brian Caffo, Susumu Mori, Tomas R Guilarte, Martin G Pomper
Importance: Microglia, the resident immune cells of the central nervous system, play an important role in the brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single and repeated traumatic brain injury, possibly through sports-related concussive and subconcussive injuries. Limited in vivo brain imaging studies months to years after individuals experience a single moderate to severe traumatic brain injury suggest widespread persistent microglial activation, but there has been little study of persistent glial cell activity in brains of athletes with sports-related traumatic brain injury...
November 28, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27892821/self-regulation-upon-return-to-driving-after-traumatic-brain-injury
#5
James R Gooden, Jennie L Ponsford, Judith L Charlton, Pamela Ross, Shawn Marshall, Sylvain Gagnon, Michel Bédard, Renerus J Stolwyk
The aim of this study was to explore self-reported driving habits and the factors associated with these within the first three months of return to driving following traumatic brain injury (TBI). Participants included 24 individuals with moderate to severe TBI (post-traumatic amnesia duration M = 33.26, SD = 29.69 days) and 28 healthy age, education, and gender-matched controls who completed an on-road assessment. Driving frequency and avoidance questionnaires were administered to assess premorbid driving, anticipated driving upon resuming, and driving at three months post-assessment...
November 28, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27891725/cognitive-task-demands-and-discourse-performance-after-traumatic-brain-injury
#6
Lindsey Byom, Lyn S Turkstra
BACKGROUND: Social communication problems are common in adults with traumatic brain injury (TBI), particularly problems in spoken discourse. Social communication problems are thought to reflect underlying cognitive impairments. AIMS: To measure the contribution of two cognitive processes, executive functioning (EF) and theory of mind (ToM), to the communication of adults with TBI, and to investigate the relationships between discourse performance and potential communication partners' perceptions...
November 27, 2016: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/27885406/abnormal-connectivity-in-the-sensorimotor-network-predicts-attention-deficits-in-traumatic-brain-injury
#7
Elena Shumskaya, Marcel A J van Gerven, David G Norris, Pieter E Vos, Roy P C Kessels
The aim of this study was to explore modifications of functional connectivity in multiple resting-state networks (RSNs) after moderate to severe traumatic brain injury (TBI) and evaluate the relationship between functional connectivity patterns and cognitive abnormalities. Forty-three moderate/severe TBI patients and 34 healthy controls (HC) underwent resting-state fMRI. Group ICA was applied to identify RSNs. Between-subject analysis was performed using dual regression. Multiple linear regressions were used to investigate the relationship between abnormal connectivity strength and neuropsychological outcome...
November 24, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27881344/-value-of-urinary-liver-fatty-acid-binding-protein-in-assessing-severity-of-brain-trauma-and-predicting-acute-kidney-injury
#8
Guang-Yong Wu, Kai Zhuang, Yu Liu, Zhi-Fei Wang
OBJECTIVE: To assess the value of urinary liver-type fatty acid-binding protein (L-FABP) in early assessment of the severity of traumatic brain injury and in predicting the occurrence of acute kidney injury (AKI) following the brain injury. METHODS: Sixty-five patients with traumatic brain injury patients were divided into 4 groups according to their Glasgow coma scale (GCS) scores. Blood and urine samples were collected at 2, 6, 12, 24, 48 and 72 h after the injury to detect serum creatinine (SCr) level using biochemical analyzer and urinary L-FABP using enzyme-linked immunosorbent assay (ELISA), with samples from 15 healthy adults as controls...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27880057/ankle-plantarflexor-spasticity-is-not-differentially-disabling-for-those-who-are-weak-following-traumatic-brain-injury
#9
Gavin Williams, Megan Banky, Dean McKenzie, John Olver
PRIMARY OBJECTIVES: The main aim of this study was to determine whether the presence of distal lower-limb spasticity had a greater impact on mobility for those who had greater levels of muscle paresis following traumatic brain injury (TBI). RESEARCH DESIGN: This was a cross-sectional cohort study of convenience. Seventy-five people attending physiotherapy for mobility limitations following TBI participated in this study. All participants had sustained a moderate-severe TBI and were grouped according to the presence or absence of ankle plantarflexor spasticity for comparison...
November 23, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27878274/regulatory-t-cells-exhibit-neuroprotective-effect-in-a-mouse-model-of-traumatic-brain-injury
#10
Yunhu Yu, Fang Cao, Qishan Ran, Xiaochuan Sun
Traumatic brain injury (TBI) is a major health and socioeconomic problem as it is associated with high rates of mortality and morbidity worldwide. Regulatory T cells (Tregs) have been reported to reduce inflammatory response in several diseases, including myasthenia gravis, viral myocarditis and cerebral infarction. The present study investigated the role of Tregs in mediating neuro‑protective effects in a mouse model of TBI. Initially, Treg levels were determined, and compared between the controlled cortical impact (CCI) model for moderate TBI and the sham group, by using flow cytometry and ELISA...
November 18, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27870900/to-fear-is-to-gain-the-role-of-fear-recognition-in-risky-decision-making-in-tbi-patients-and-healthy-controls
#11
Annemarie C Visser-Keizer, Herma J Westerhof-Evers, Marleen J J Gerritsen, Joukje van der Naalt, Jacoba M Spikman
Fear is an important emotional reaction that guides decision making in situations of ambiguity or uncertainty. Both recognition of facial expressions of fear and decision making ability can be impaired after traumatic brain injury (TBI), in particular when the frontal lobe is damaged. So far, it has not been investigated how recognition of fear influences risk behavior in healthy subjects and TBI patients. The ability to recognize fear is thought to be related to the ability to experience fear and to use it as a warning signal to guide decision making...
2016: PloS One
https://www.readbyqxmd.com/read/27864465/posttraumatic-therapeutic-hypothermia-alters-microglial-and-macrophage-polarization-toward-a-beneficial-phenotype
#12
Jessie S Truettner, Helen M Bramlett, W Dalton Dietrich
Posttraumatic inflammatory processes contribute to pathological and reparative processes observed after traumatic brain injury (TBI). Recent findings have emphasized that these divergent effects result from subsets of proinflammatory (M1) or anti-inflammatory (M2) microglia and macrophages. Therapeutic hypothermia has been tested in preclinical and clinical models of TBI to limit secondary injury mechanisms including proinflammatory processes. This study evaluated the effects of posttraumatic hypothermia (PTH) on phenotype patterns of microglia/macrophages...
November 18, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27857878/magnetic-resonance-imaging-assessment-of-vascular-contact-of-the-facial-nerve-in-the-asymptomatic-patient
#13
Nicholas L Deep, Geoffrey P Fletcher, Kent D Nelson, Ameet C Patel, David M Barrs, Bernard R Bendok, Joseph M Hoxworth
Objective The objective of this study was to determine the prevalence of facial nerve vascular contact on magnetic resonance imaging (MRI) in patients without hemifacial spasm (HFS). Study Design Our radiology database was queried to identify consecutive adult patients without a history of HFS, intracranial tumor, brain radiation therapy, intracranial surgery, traumatic brain injury, or trigeminal nerve vascular compression. One hundred high-resolution MRIs of the posterior fossa were independently reviewed by two neuroradiologists for facial nerve vascular contact (200 sides)...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27853132/traumatic-brain-injuries
#14
Kaj Blennow, David L Brody, Patrick M Kochanek, Harvey Levin, Ann McKee, Gerard M Ribbers, Kristine Yaffe, Henrik Zetterberg
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury - the best-studied pathogenetic mechanism of this disorder. However, mild TBI is defined on clinical grounds and no well-validated imaging or fluid biomarkers to determine the presence of neuronal damage in patients with mild TBI is available...
November 17, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27850440/802-disposition-of-children-with-mild-to-moderate-traumatic-brain-injury-and-positive-head-imaging
#15
Corina Noje, Eric Jackson, Isam Nasr, Philomena Costabile, Eric Henderson, Marcelo Cerullo, Katherine Hoops, Courtney Robertson
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27833541/cognitive-training-for-post-acute-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#16
Harry Hallock, Daniel Collins, Amit Lampit, Kiran Deol, Jennifer Fleming, Michael Valenzuela
Objective: To quantitatively aggregate effects of cognitive training (CT) on cognitive and functional outcome measures in patients with traumatic brain injury (TBI) more than 12-months post-injury. Design: We systematically searched six databases for non-randomized and randomized controlled trials of CT in TBI patients at least 12-months post-injury reporting cognitive and/or functional outcomes. Main Measures: Efficacy was measured as standardized mean difference (Hedges' g) of post-training change. We investigated heterogeneity across studies using subgroup analyses and meta-regressions...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27831731/behavioral-inhibition-and-activation-systems-in-traumatic-brain-injury
#17
Christina G Wong, Lisa J Rapport, Sarah-Jane Meachen, Robin A Hanks, Mark A Lumley
PURPOSE/OBJECTIVE: Personality has been linked to cognitive appraisal and health outcomes; however, research specific to traumatic brain injury (TBI) has been sparse. Gray's theory of behavioral inhibition system and behavioral activation system (BIS/BAS) offers a neurobiologic view of personality that may be especially relevant to neurobehavioral change associated with TBI. The present study examined theoretical and psychometric issues of using the BIS/BAS scale among adults with TBI as well as BIS/BAS personality correlates of TBI...
November 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27831729/a-randomized-problem-solving-trial-for-adolescent-brain-injury-changes-in-social-competence
#18
Sarah J Tlustos, Michael W Kirkwood, H Gerry Taylor, Terry Stancin, Tanya M Brown, Shari L Wade
PURPOSE/OBJECTIVE: Traumatic brain injury (TBI) in adolescence has well documented effects on social competence. Few studies have examined the effects of behavioral interventions on social competence or identified factors associated with changes in social competence after injury. Research Method/Design: Adolescents with moderate to severe TBI ages 12-17 years were randomized within 6 months of injury to either a problem solving and communication (CAPS) group that received online counseling (n = 65) or an Internet resources comparison (IRC) group (n = 67) for a comparative effectiveness trial...
November 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27829310/traumatic-brain-injury-and-alcohol-substance-abuse-a-bayesian-meta-analysis-comparing-the-outcomes-of-people-with-and-without-a-history-of-abuse
#19
David J Unsworth, Jane L Mathias
Alcohol and substance (drugs and/or alcohol) abuse are major risk factors for traumatic brain injury (TBI); however, it remains unclear whether outcomes differ for those with and without a history of preinjury abuse. A meta-analysis was performed to examine this issue. The PubMed, Embase, and PsycINFO databases were searched for research that compared the neuroradiological, cognitive, or psychological outcomes of adults with and without a documented history of alcohol and/or substance abuse who sustained nonpenetrating TBIs...
November 10, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27821129/traumatic-brain-injury-patient-volume-and-mortality-in-neurosurgical-intensive-care-units-a-finnish-nationwide-study
#20
Rahul Raj, Stepani Bendel, Matti Reinikainen, Sanna Hoppu, Teemu Luoto, Tero Ala-Kokko, Sami Tetri, Ruut Laitio, Timo Koivisto, Jaakko Rinne, Riku Kivisaari, Jari Siironen, Markus B Skrifvars
BACKGROUND: Differences in outcomes after traumatic brain injury (TBI) between neurosurgical centers exist, although the reasons for this are not clear. Thus, our aim was to assess the association between the annual volume of TBI patients and mortality in neurosurgical intensive care units (NICUs). METHODS: We collected data on all patients treated in the five Finnish university hospitals to examine all patients with TBI treated in NICUs in Finland from 2009 to 2012...
November 8, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
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