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Moderate traumatic brain injury

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https://www.readbyqxmd.com/read/28533863/management-and-outcome-of-traumatic-brain-injury-patients-at-muhimbili-orthopaedic-institute-dar-es-salaam-tanzania
#1
Respicious Boniface, Edwin Rwebugisa Lugazia, Abel Mussa Ntungi, Othman Kiloloma
INTRODUCTION: Traumatic brain Injuries represents a significant cause of morbidity and mortality worldwide and road traffic crashes accounts for a significant proportion of these injuries. However, access to neurosurgical care is poor in low income countries like Tanzania. The aim of this study was to assess the management and outcome of Traumatic brain injury patients at a tertiary level health facility in Tanzania. METHODS: A retrospective observational study of Traumatic brain injury patients attended at Muhimbili Orthopedic Institute between January 2014 and June 2014...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28533826/a-novel-triage-tool-optic-nerve-sheath-diameter-in-traumatic-brain-injury-and-its-correlation-to-rotterdam-computed-tomography-ct-scoring
#2
Sudha Kiran Das, Sachin P Shetty, Kamal Kumar Sen
BACKGROUND: Optic nerve sheath diameter (ONSD) evaluated in CT imaging as well as Rotterdam CT Score (RCTS) are proven independent predictors of outcome in patients with traumatic brain injury (TBI). To date, no study has correlated ONSD on admission CT scan with RCTS. MATERIAL/METHODS: Retrospective cohort study comprised of consecutive patients undergoing CT imaging for traumatic brain injury recruited between January and October 2015. Bilateral ONSD was measured 3 mm behind the eyeball in axial and sagittal planes and mean value was calculated...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28529912/female-gonadal-hormone-effects-on-microglial-activation-and-functional-outcomes-in-a-mouse-model-of-moderate-traumatic-brain-injury
#3
Odera Umeano, Haichen Wang, Hana Dawson, Beilei Lei, Afoma Umeano, Dawn Kernagis, Michael L James
AIM: To address the hypothesis that young, gonad-intact female mice have improved long-term recovery associated with decreased neuroinflammation compared to male mice. METHODS: Eight to ten week-old male, female, and ovariectomized (OVX) mice underwent closed cranial impact. Gonad-intact female mice were injured only in estrus state. After injury, between group differences were assessed using complementary immunohistochemical staining for microglial cells at 1 h, mRNA polymerase chain reaction for inflammatory markers at 1 h after injury, Rotarod over days 1-7, and water maze on days 28-31 after injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28529492/depression-in-men-and-women-one-year-following-traumatic-brain-injury-tbi-a-tbi-model-systems-study
#4
Sarah Lavoie, Samantha Sechrist, Nhung Quach, Reza Ehsanian, Thao Duong, Ian H Gotlib, Linda Isaac
In the general population, females experience depression at significantly higher rates than males. Individuals with traumatic brain injury (TBI) are at substantially greater risk for depression compared to the overall population. Treatment of, and recovery from, TBI can be hindered by depression; comorbid TBI and depression can lead to adverse outcomes and negatively affect multiple aspects of individuals' lives. Gender differences in depression following TBI are not well understood, and relevant empirical findings have been mixed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28524120/proton-magnetic-resonance-spectroscopy-%C3%A2-h-mrs-study-of-early-traumatic-brain-injury-in-rabbits
#5
Yong Xiao, Yigang Fu, Yi Zhou, Jianguo Xia, Lina Wang, Chunhong Hu
BACKGROUND The aim of this study was to investigate the relationship between dynamic changes of cerebral metabolism and degree of trauma in rabbit models of traumatic brain injury (TBI) by using proton magnetic resonance spectroscopy (¹H-MRS). MATERIAL AND METHODS Thirty-five Chinese rabbits were randomly divided into control, mild, moderate, and severe TBI groups. ¹H-MRS was performed 1, 6, and 24 h after trauma. The concentrations of NAA, Cr, Cho, and Lac, and NAA/Cr and Cho/Cr ratios in each group, were estimated...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28520675/the-role-of-cognitive-reserve-in-recovery-from-traumatic-brain-injury
#6
Kayla A Steward, Richard Kennedy, Thomas A Novack, Michael Crowe, Daniel C Marson, Kristen L Triebel
OBJECTIVE: To examine whether cognitive reserve (CR) attenuates the initial impact of traumatic brain injury (TBI) on cognitive performance (neural reserve) and results in faster cognitive recovery rates in the first year postinjury (neural compensation), and whether the advantage of CR differs on the basis of the severity of TBI. SETTING: Inpatient/outpatient clinics at an academic medical center. PARTICIPANTS: Adults with mild TBI (mTBI; n = 28), complicated mild TBI (cmTBI; n = 24), and moderate to severe TBI (msevTBI; n = 57), and demographically matched controls (n = 66)...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520673/behavioral-clinical-trials-in-moderate-to-severe-pediatric-traumatic-brain-injury-challenges-potential-solutions-and-lessons-learned
#7
Shari L Wade, Brad G Kurowski
The purpose of this commentary is to outline the challenges encountered when conducting clinical trials of interventions for pediatric traumatic brain injury (TBI) and share potential solutions for surmounting these issues. This commentary grows out of our experience implementing 8 randomized clinical trials (RCTs) of family-centered interventions to reduce child behavior problems and caregiver/parent distress following pediatric brain injury. These studies, involving more than 600 participants from 8 clinical centers, support the feasibility of conducting RCTs with children who have sustained TBIs while highlighting potential challenges and threats to validity...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520669/investigating-the-connection-between-traumatic-brain-injury-and-posttraumatic-stress-symptoms-in-adolescents
#8
Tara Rhine, Amy Cassedy, Keith Owen Yeates, Hudson Gerry Taylor, Michael W Kirkwood, Shari L Wade
OBJECTIVE: To identify potentially modifiable individual and social-environmental correlates of posttraumatic stress symptoms (PTSS) among adolescents hospitalized for traumatic brain injury (TBI). SETTING: Four pediatric hospitals and 1 general hospital in the United States. PARTICIPANTS: Children ages 11 to 18 years, hospitalized for moderate-severe TBI within the past 18 months. DESIGN: Retrospective cross-sectional analysis...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520667/supervision-needs-following-veteran-and-service-member-moderate-to-severe-traumatic-brain-injury-a-va-tbi-model-systems-study
#9
Erin K Bailey, Risa Nakase-Richardson, Nitin Patel, Christina Dillahunt-Aspillaga, Susan A Ropacki, Angelle M Sander, Lillian Stevens, Xinyu Tang
OBJECTIVE: To characterize supervision levels across residential settings at 1 year post-TBI and explore predictors of supervision in a Veteran and Service-member population. SETTING: Five VA Polytrauma Rehabilitation Centers. PARTICIPANTS: A total of 302 individuals enrolled in the VA TBI Model Systems (TBIMS) research program. DESIGN: Prospective, longitudinal, multisite. MAIN MEASURES: Primary residence and supervision levels measured via scores on the Supervision Rating Scale...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520666/anger-self-management-training-for-chronic-moderate-to-severe-traumatic-brain-injury-results-of-a-randomized-controlled-trial
#10
Tessa Hart, Jo Ann Brockway, Roland D Maiuro, Monica Vaccaro, Jesse R Fann, David Mellick, Cindy Harrison-Felix, Jason Barber, Nancy Temkin
OBJECTIVE: To test efficacy of 8-session, 1:1 treatment, anger self-management training (ASMT), for chronic moderate to severe traumatic brain injury (TBI). SETTING: Three US outpatient treatment facilities. PARTICIPANTS: Ninety people with TBI and elevated self-reported anger; 76 significant others (SOs) provided collateral data. DESIGN: Multicenter randomized controlled trial with 2:1 randomization to ASMT or structurally equivalent comparison treatment, personal readjustment and education (PRE)...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520662/anxiety-disorders-in-adults-with-childhood-traumatic-brain-injury-evidence-of-difficulties-more-than-10-years-postinjury
#11
Michelle Albicini, Audrey McKinlay
OBJECTIVE: To explore long-term psychiatric outcomes in individuals with a history of childhood traumatic brain injury (TBI) or orthopedic injury (OI). SETTING: Hospital emergency department, medical admission records and outpatient settings. PARTICIPANTS: There were 95 males (M = 22.78 years, SD = 3.44 years) and 74 females (M = 22.27 years, SD = 3.09 years), 65 with mild TBI (M = 23.25 years, SD = 3.58 years), 61 with moderate-severe TBI (M = 22...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28511727/rejection-sensitivity-as-a-moderator-of-psychosocial-outcomes-following-pediatric-traumatic-brain-injury
#12
Emily A Meadows, Keith Owen Yeates, Kenneth H Rubin, H Gerry Taylor, Erin D Bigler, Maureen Dennis, Cynthia A Gerhardt, Kathryn Vannatta, Terry Stancin, Kristen R Hoskinson
OBJECTIVES: The current study examines whether psychosocial outcomes following pediatric traumatic brain injury (TBI) vary as a function of children's rejection sensitivity (RS), defined as their disposition to be hypersensitive to cues of rejection from peers. METHODS: Children ages 8-13 with a history of severe TBI (STBI, n=16), complicated mild/moderate TBI (n=35), or orthopedic injury (OI, n=49) completed measures assessing self-esteem and RS on average 3.28 years post-injury (SD=1...
May 17, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28507895/diverging-volumetric-trajectories-following-pediatric-traumatic-brain-injury
#13
Emily L Dennis, Joshua Faskowitz, Faisal Rashid, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Neda Jahanshad, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development. There is considerable heterogeneity in post-injury outcomes, only partially explained by injury severity. Understanding the time course of recovery, and what factors may delay or promote recovery, will aid clinicians in decision-making and provide avenues for future mechanism-based therapeutics. We examined regional changes in brain volume in a pediatric/adolescent moderate-severe TBI (msTBI) cohort, assessed at two time points...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28507314/metabolic-imaging-of-energy-metabolism-in-traumatic-brain-injury-using-hyperpolarized-1-13-c-pyruvate
#14
Stephen J DeVience, Xin Lu, Julie Proctor, Parisa Rangghran, Elias R Melhem, Rao Gullapalli, Gary M Fiskum, Dirk Mayer
Traumatic brain injury (TBI) is known to cause perturbations in the energy metabolism of the brain, but current tests of metabolic activity are only indirect markers of energy use or are highly invasive. Here we show that hyperpolarized (13)C magnetic resonance spectroscopic imaging (MRSI) can be used as a direct, non-invasive method for studying the effects of TBI on energy metabolism. Measurements were performed on rats with moderate TBI induced by controlled cortical impact on one cerebral hemisphere. Following injection of hyperpolarized [1-(13)C]pyruvate, the resulting (13)C-bicarbonate signal was found to be 24 ± 6% lower in the injured hemisphere compared with the non-injured hemisphere, while the hyperpolarized bicarbonate-to-lactate ratio was 33 ± 8% lower in the injured hemisphere...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506081/epidemiological-characteristics-of-chinese-paediatric-traumatic-brain-injury-inpatients
#15
Yunming Li, Fuqin Chen, Junran Zhang, Gang Li, Xiaoguang Yang, Qiang Lu, Xun Xia, Xinyan Zhang, Jun Qiu, Junpeng Zhang, Jihong Zhou, Yongqin Kuang, Jianwen Gu
PRIMARY OBJECTIVE: To investigate the epidemiological characteristics of paediatric inpatients with traumatic brain injury (TBI) in China. RESEARCH DESIGN: The Chinese Trauma Database (CTD), a nationwide register system based on hospital admission data, contains diagnosis and treatment information for trauma inpatients in over 200 military-managed public-service hospitals in China. Using the ICD-9 coding, the data for children with TBI aged 0-17 years between 2001 and 2007 were retrieved...
May 16, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28502803/gene-co-expression-networks-identify-trem2-and-tyrobp-as-major-hubs-in-human-apoe-expressing-mice-following-traumatic-brain-injury
#16
Emilie L Castranio, Anais Mounier, Cody M Wolfe, Kyong Nyon Nam, Nicholas F Fitz, Florent Letronne, Jonathan Schug, Radosveta Koldamova, Iliya Lefterov
Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD). APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset AD and has been associated with chronic traumatic encephalopathy and unfavorable outcome following TBI. To determine if there is an APOE isoform-specific response to TBI we performed controlled cortical impact on 3-month-old mice expressing human APOE3 or APOE4 isoforms...
May 11, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28499842/establishing-the-ferret-as-a-gyrencephalic-animal-model-of-traumatic-brain-injury-optimization-of-controlled-cortical-impact-procedures
#17
Susan C Schwerin, Elizabeth B Hutchinson, Kryslaine L Radomski, Kapinga P Ngalula, Carlo M Pierpaoli, Sharon L Juliano
BACKGROUND: Although rodent TBI studies provide valuable information regarding the effects of injury and recovery, an animal model with neuroanatomical characteristics closer to humans may provide a more meaningful basis for clinical translation. The ferret has a high white/gray matter ratio, gyrencephalic neocortex, and ventral hippocampal location. Furthermore, ferrets are amenable to behavioral training, have a body size compatible with pre-clinical MRI, and are cost-effective. NEW METHODS: We optimized the surgical procedure for controlled cortical impact (CCI) using 9 adult male ferrets...
May 10, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28489704/factors-associated-with-rehabilitation-outcomes-after-traumatic-brain-injury-comparing-functional-outcomes-between-tbims-centers-using-hierarchical-linear-modeling
#18
Marie N Dahdah, Melissa Hofmann, Christopher Pretz, Viktoriya An, Sunni A Barnes, Monica Bennett, Laura E Dreer, Thomas Bergquist, Shahid Shafi
OBJECTIVE: To examine differences in patient outcomes across Traumatic Brain Injury Model Systems (TBIMS) rehabilitation centers and factors that influence these differences using hierarchical linear modeling (HLM). SETTING: Sixteen TBIMS centers. PARTICIPANTS: A total of 2056 individuals 16 years or older with moderate to severe traumatic brain injury (TBI) who received inpatient rehabilitation. DESIGN: Multicenter observational cohort study using HLM to analyze prospectively collected data...
November 8, 2016: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28489700/p300-event-related-potentials-differentiate-better-performing-individuals-with-traumatic-brain-injury-a-preliminary-study-of-semantic-processing
#19
Tara M Davis, Benjamin D Hill, Kelli J Evans, Shelby Tiffin, Nicholas Stanley, Kelly Fields, Katherine Russ, Huybrechts Frazier Bindele, Susan Gordon-Hickey
OBJECTIVE: To measure the effect of traumatic brain injury on the cognitive processing of words, as measured by the P300, in a semantic categorization task. PARTICIPANTS: Eight adults with a history of moderate to severe traumatic brain injury and 8 age- and gender-matched controls. DESIGN: A pilot study measuring cognitive event-related potentials in response to word pairs that were either in same or different semantic categories. MAIN MEASURES: The P300 (P3b) component of the auditory event-related potential and neuropsychological assessment...
November 8, 2016: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28489656/consequences-of-traumatic-brain-injury-in-professional-american-football-players-a-systematic-review-of-the-literature
#20
Bodil C Vos, Karen Nieuwenhuijsen, Judith K Sluiter
OBJECTIVE: The purpose of this study was to systematically review the literature for the consequences Traumatic brain injury (TBI) has on cognitive, psychological, physical, and sports-related functioning in professional American Football players. DATA SOURCES: We performed a systematic search in 2 databases, PubMed and SPORTDiscus, to obtain literature from January 1990 to January 2015. To be eligible for inclusion, a study had to examine the relationship between TBI and the consequences for several aspects of functioning in professional American football players older than 18 years...
May 9, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
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