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https://www.readbyqxmd.com/read/29779644/development-of-a-novel-tissue-engineered-nitinol-frame-artificial-trachea-with-native-like-physical-characteristics
#1
Yasuto Sakaguchi, Toshihiko Sato, Yusuke Muranishi, Yojiro Yutaka, Teruya Komatsu, Koichi Omori, Tatsuo Nakamura, Hiroshi Date
BACKGROUND: Tracheal reconstruction is complicated by the short length to which a trachea can be resected. We previously developed a biocompatible polypropylene frame artificial trachea, but it lacked the strength and flexibility of the native trachea. In contrast, nitinol may provide these physical characteristics. We developed a novel nitinol frame artificial trachea and examined its biocompatibility and safety in canine models. METHODS: We constructed several nitinol frame prototypes and selected the frame that most closely reproduced the strength of the native canine trachea...
April 24, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29759990/epigenetic-targeting-of-adipocytes-inhibits-high-grade-serous-ovarian-cancer-cell-migration-and-invasion
#2
Jessica Tang, Nicholas Pulliam, Ali Ozes, Aaron Buechlein, Ning Ding, Doug Rusch, Harold Keer, Heather O'Hagan, M Sharon Stack, Kenneth P Nephew
Ovarian cancer (OC) cells frequently metastasize to the omentum and adipocytes play a significant role in ovarian tumor progression. Therapeutic interventions targeting aberrant DNA methylation in ovarian tumors have shown promise in the clinic but the effects of epigenetic therapy on the tumor microenvironment are understudied. Here, we examined the effect of adipocytes on OC cell behavior in culture and impact of targeting DNA methylation in adipocytes on OC metastasis. The presence of adipocytes increased OC cell migration and invasion and proximal and direct co-culture of adipocytes increased OC proliferation alone or after treatment with carboplatin...
May 14, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29758389/gallbladder-perforation-into-the-greater-omentum-following-sleeve-gastrectomy-a-case-report-study
#3
Suhaib J S Ahmad, Sherif M Hakky, Douglas McWhinnie, Claire J Stocker, Peter Thomas, Sami Ahmad
INTRODUCTION: Obesity is considered a major risk factor for gallstone formation and is important due to its increasing prevalence worldwide. Many studies have reported an increased incidence of gallstone formation following bariatric surgery. This report documents a rare case of a complicated cholecystitis following sleeve gastrectomy and describes our management of the case and the management options for gallbladder disease in bariatric patients. PRESENTATION OF CASE: A 60-year-old male was diagnosed with asymptomatic cholelithiasis at the time of sleeve gastrectomy for obesity treatment...
May 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29755664/identification-of-core-aberrantly-expressed-micrornas-in-serous-ovarian-carcinoma
#4
Steven F Chen, Zheng Liu, Shyambabu Chaurasiya, Thanh H Dellinger, Jianming Lu, Xiwei Wu, Hanjun Qin, Jinhui Wang, Yuman Fong, Yate-Ching Yuan
MicroRNAs (miRNAs) have recently demonstrated great potential and enormous promise in the diagnosis, prognosis and therapy of various types of cancer. In this study, we performed a comprehensive miRNA expression analysis in the omental metastasis of serous ovarian carcinoma (SOC) using small RNA sequencing. Two hundred and fifty-one aberrantly expressed miRNAs were identified, which clearly separated malignant omentum from normal omentum. Furthermore, miRNA profiles in primary chemo-sensitive and chemo-resistant/refractory SOC were determined using publicly available data...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29750700/assessment-of-a-chemotherapy-response-score-crs-system-for-tubo-ovarian-high-grade-serous-carcinoma-hgsc
#5
Helena M Ditzel, Kyle C Strickland, Emily E Meserve, Elizabeth Stover, Panagiotis A Konstantinopoulos, Ursula A Matulonis, Michael G Muto, Joyce F Liu, Colleen Feltmate, Neil Horowitz, Ross S Berkowitz, Mamta Gupta, Jonathan L Hecht, Douglas I Lin, Kirsten M Jochumsen, William R Welch, Michelle S Hirsch, Bradley J Quade, Kenneth R Lee, Christopher P Crum, George L Mutter, Marisa R Nucci, Brooke E Howitt
A chemotherapy response score (CRS) system was recently described to assess the histopathologic response and prognosis of patients with tubo-ovarian high-grade serous carcinoma (HGSC) receiving neoadjuvant chemotherapy. The current study was performed as an independent assessment of this CRS system. We retrospectively identified advanced stage HGSC patients who received neoadjuvant chemotherapy and underwent interval debulking. If available, a hemotoxylin and eosin slide from the omentum and the adnexa was selected for the study...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29740426/multipotent-adult-progenitor-cells-suppress-t-cell-activation-in-in-vivo-models-of-homeostatic-proliferation-in-a-prostaglandin-e2-dependent-manner
#6
Fiona Carty, Jennifer M Corbett, João Paulo M C M Cunha, James L Reading, Timothy I M Tree, Anthony E Ting, Samantha R Stubblefield, Karen English
Lymphodepletion strategies are used in the setting of transplantation (including bone marrow, hematopoietic cell, and solid organ) to create space or to prevent allograft rejection and graft versus host disease. Following lymphodepletion, there is an excess of IL-7 available, and T cells that escape depletion respond to this cytokine undergoing accelerated proliferation. Moreover, this environment promotes the skew of T cells to a Th1 pro-inflammatory phenotype. Existing immunosuppressive regimens fail to control this homeostatic proliferative (HP) response, and thus the development of strategies to successfully control HP while sparing T cell reconstitution (providing a functioning immune system) represents a significant unmet need in patients requiring lymphodepletion...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29739764/left-sided-omental-infarction-a-rare-cause-of-abdominal-pain-discovered-by-ct-scan
#7
Jamie L G Nijkamp, Suzanne C Gerretsen, Patricia M Stassen
Omental infarction in adults is a rarely occurring phenomenon, with left-sided omental infarction being even more seldom. The importance of this case report lies in raising awareness of the diagnosis omental infarction as a cause of acute abdomen among doctors who work in the emergency department, in order to prevent unnecessary surgical interventions as conservative treatment generally solves the problem. Omental infarction is the result of vascular obstruction and ends in tissue ischaemia. Because of the rich vasculature of the greater omentum, anastomoses reorganise the vascularisation, which explains the mostly benign course of omental infarction...
May 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29737310/is-laparoscopic-approach-for-wandering-spleen-in-children-an-option
#8
REVIEW
Gratiana Oana Alqadi, Amulya K Saxena
Aim: Wandering spleen present generally as an acute abdomen after twisting of the splenic vascular pedicle. This study aimed to review the literature with regard to the management and outcomes of the laparoscopy in children with wandering spleen. Methods: The literature was reviewed for articles on PubMed with regard to the following search terms 'laparoscopy', 'wandering', 'spleen' and 'children'. The inclusion criteria included article only in the paediatric age group of 0-16...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29730733/robotic-assisted-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#9
Emmanuel Gabriel, Enrique Elli, Sanjay Bagaria, Nabil Wasif, Travis Grotz, John Stauffer, Pashtoon M Kasi, Horacio Asbun
BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an appropriate treatment for select patients with peritoneal carcinomatosis. While most commonly performed through an open incision, the laparoscopic approach has been reported and offers short-term benefits. A robotic-assisted approach for carcinomatosis of gastrointestinal origin, however, has not yet been described. METHODS: We report our approach to robotic-assisted CRS-HIPEC for a patient with a perforated appendiceal mucocele...
May 5, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29727323/selected-case-from-the-arkadi-m-rywlin-international-pathology-slide-club-peritoneal-lipofuscinosis-and-deciduosis-in-pregnancy
#10
Dimuth N Gunawardane, Philip W Allen
Peritoneal lipofuscinosis is a very rarely recognized condition occurring during pregnancy characterized by brown pigmentation of the omentum and peritoneum, a decidual reaction and benign mesothelial cells. The iron negative pigment, which is likely to be confused with hemosiderin in the hematoxylin and eosin stain, is lipofuscin. The seminar case, apparently the third published, arose in a 37-year-old woman who presented in October 2015 at 24 weeks pregnancy with abdominal pain. Investigations revealed a ruptured left ovarian cyst and rising serum carcinoembryonic antige levels...
April 30, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29725538/appendiceal-carcinoma-associated-with-microsatellite-instability
#11
Angélica Morales-Miranda, Ismael Domínguez Rosado, Carlos Chan Núñez, Fredy Chable Montero
Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique biological behavior. The present study presents a case of appendiceal carcinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-old male patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, following an acute attack, he was subjected to laparoscopic appendectomy...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29715595/design-of-a-vascularized-synthetic-poly-ethylene-glycol-macroencapsulation-device-for-islet-transplantation
#12
Jessica D Weaver, Devon M Headen, Michael D Hunckler, Maria M Coronel, Cherie L Stabler, Andrés J García
The use of immunoisolating macrodevices in islet transplantation confers the benefit of safety and translatability by containing transplanted cells within a single retrievable device. To date, there has been limited development and characterization of synthetic poly(ethylene glycol) (PEG)-based hydrogel macrodevices for islet encapsulation and transplantation. Herein, we describe a two-component synthetic PEG hydrogel macrodevice system, designed for islet delivery to an extrahepatic islet transplant site, consisting of a hydrogel core cross-linked with a non-degradable PEG dithiol and a vasculogenic outer layer cross-linked with a proteolytically sensitive peptide to promote degradation and enhance localized vascularization...
April 25, 2018: Biomaterials
https://www.readbyqxmd.com/read/29713558/effect-of-4dryfield-%C3%A2-ph-a-novel-adhesion-barrier-on-recurrence-of-intestinal-adhesions-after-extensive-visceral-adhesiolysis
#13
Gerhard Blumhardt, Matthias Haas, Stefanie Polte
Background: Adhesions occur after up to 97% of abdominal interventions causing chronic pain, infertility, and intestinal obstruction. Various concepts to prevent adhesions have been presented but mostly either have low efficacy or are not applicable in resective intestinal surgery or incomplete hemostasis. In this retrospective one-center clinical trial, the course of patients with extensive abdominal adhesiolysis and application of a recent starch-based formulation, 4DryField PH (4DF), is analyzed...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29703236/high-grade-serous-carcinoma-with-discordant-p53-signature-report-of-a-case-with-new-insight-regarding-high-grade-serous-carcinogenesis
#14
Yuichiro Hatano, Shinya Fukuda, Hiroshi Makino, Hiroyuki Tomita, Ken-Ichirou Morishige, Akira Hara
BACKGROUND: Although p53 signature, benign-appearing epithelial cells with p53 diffuse expression, is frequently found in the fallopian tubes, the clinical and pathological significance of this lesion in the case of high-grade serous carcinoma (HGSC) patients still remains unclear. CASE PRESENTATION: A 56-year-old woman was referred to the gynecologist on account of abdominal distention. Since radiological and serological workup suggested that her illness was due to advanced ovarian cancer (FIGO Stage IVB), she received neoadjuvant chemotherapy, and the clinical evaluation of the chemotherapeutic response was a partial response...
April 27, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29695575/laparoscopic-left-hepatectomy-for-ruptured-hepatocellular-carcinoma-controlled-after-transcatheter-arterial-embolization-case-report-and-review-of-the-literature
#15
Shohei Yoshiya, Kentaro Iwaki, Akihiro Sakai, Shunsuke Fujita, Takahide Kawasaki, Fumitaka Yoshizumi, Shoji Hiroshige, Masahiro Okamoto, Kengo Fukuzawa, Akira Motohiro, Yoshihiko Maehara
BACKGROUND: Although spontaneous tumour rupture is a life-threatening complication of hepatocellular carcinoma (HCC), staged hepatectomy for HCC controlled after transcatheter arterial embolization (TAE) could provide a better prognosis. Laparoscopic liver resection (LLR) has been accepted worldwide and has been expanded from minor resection to anatomical major resection. We herein report the first case of pure laparoscopic left hepatectomy for ruptured HCC controlled after TAE. CASE REPORT: A 66-year-old man was transferred to our Institute because of abdominal pain and decreased consciousness...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29693335/preoperative-monocyte-count-as-a-mirror-of-tumor-characteristics-and-likelihood-of-recurrence-in-endometrial-carcinoma-cases
#16
Mitra Modares Gilani, Zohreh Kazemi, Narges Zamani, Hadis Shahrami, Akram Ghahghaei-Nezamabadi, Soureh Sheikham
Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29682388/granulomatosis-with-polyangiitis-localized-in-the-greater-omentum
#17
Ryuji Komine, Takashi Kobayashi, Hiro Uehara, Keisuke Minamimura, Kazuhiko Mori, Toru Hirata, Atsushi Shimizu, Masaya Mori
Granulomatosis with polyangiitis (GPA) is known as anti-neutrophil cytoplasmic antibody- (ANCA-) associated small vessel vasculitis and typically manifests as pulmonary-renal syndrome, but the disease is not limited to pulmonary or renal systems. The inflammation can involve whole body organs. In addition, the ANCA titer does not always become positive. Here, we describe the case of a 91-year-old man who presented with umbilical pain and fever of unknown origin. Only the increased computed tomography value of the greater omentum suggested intra-abdominal inflammation; however, serological examinations, including the ANCA level, could not reveal the focus or cause of symptoms...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29679171/pedicled-gastric-seromuscular-patch-for-one-stage-closure-of-a-bronchopleural-fistula-a-case-report
#18
Jun Suzuki, Hiroyuki Oizumi, Hirohisa Kato, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Takayuki Sasage, Mitsuaki Sadahiro
BACKGROUND: One-stage closure and fenestration are the available surgical options for bronchopleural fistula (BPF). One-stage closure may be applicable in cases with favorable infection control. Closing the bronchopleural stump is difficult due to thick adhesion caused by inflammation and a high risk of pulmonary artery injury. We report the successful closure of a BPF using a gastric seromuscular patch with an omental pedicle flap. CASE PRESENTATION: A 73-year-old man underwent right lower lobectomy with ND2a-2 lymph node dissection for lung adenocarcinoma...
April 20, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29666745/torsion-of-the-omentum-a-rare-cause-of-acute-abdomen-in-a-14-year-old-boy
#19
Chijioke Chinaka, Shahbaz Mansoor, Mohamed Salaheidin
Acute abdominal pain is a common surgical presentation, and most often, the first line of consideration is to rule out acute appendicitis; this is more so when the patient is an adolescent or within younger age group. In most cases, other differentials are considered before omental torsion. Omental torsion is a cause of acute abdominal pain and sometimes mimics acute appendicitis in its presentation. We present a case of a 14-yr-old boy who presented with acute abdomen with symptoms mimicking acute appendicitis...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29666076/histoplasma-meets-crohn-s-disease-a-rare-case-of-new-onset-ascites
#20
Charles Robert Bosshardt, John Gnann, Nilesh Lodhia
A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites. Further studies revealed weakly positive urine and serum histoplasma antigen. Laparoscopy revealed metastatic caking of the omentum and abdominal wall; peritoneal biopsy demonstrated organisms morphologically consistent with Histoplasma capsulatum No dissemination outside of the peritoneal cavity was evident...
April 17, 2018: BMJ Case Reports
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