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https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#1
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28819967/enzymatic-peg-poly-amine-co-disulfide-ester-nanoparticles-as-ph-and-redox-responsive-drug-nanocarriers-for-efficient-antitumor-treatment
#2
Ya Chen, Meifei Su, Yingqin Li, Jinbiao Gao, Chao Zhang, Zhong Cao, Jiangbing Zhou, Jie Liu, Zhaozhong Jiang
We have designed and constructed novel multifunctional nanoparticle drug delivery systems that are stable under physiological conditions and responsive to tumor-relevant pH and intracellular reduction potential. The nanoparticles were fabricated from enzymatically synthesized PEG-poly(ω-pentadecalactone-co-N-methyldiethyleneamine-co-3,3'-dithiodipropionate) (PEG-PPMD) and PEG-poly(ε-caprolactone-co-N-methyldiethyleneamine-co-3,3'-dithiodipropionate) (PEG-PCMD) block copolymers via self-assembly processes in aqueous solution...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28819454/a-novel-mpeg-pdlla-pll-copolymer-for-docetaxel-delivery-in-breast-cancer-therapy
#3
Liwei Tan, Jinrong Peng, Qian Zhao, Lan Zhang, Xichuan Tang, Lijuan Chen, Minyi Lei, Zhiyong Qian
Satisfactory drug loading capacity and stability are the two main factors that determine the anti-cancer performance. In general, the stability of the micelles is reduced when the drug loading (DL) is increased. Therefore, it was a challenge to have high drug loading capacity and good stability. In this study, we introduced a hydrophilic poly (L-Lysine) (PLL) segment with different molecular-weights into the monomethoxy poly (ethylene glycol)-poly (D, L-lactide) (MPEG-PDLLA) block copolymer to obtain a series of novel triblock MPEG-PDLLA-PLL copolymers...
2017: Theranostics
https://www.readbyqxmd.com/read/28818703/traceable-peo-poly-ester-micelles-for-breast-cancer-targeting-the%C3%A2-effect-of-core-structure-and-targeting-peptide-on-micellar-tumor%C3%A2-accumulation
#4
Shyam M Garg, Igor M Paiva, Mohammad R Vakili, Rania Soudy, Kate Agopsowicz, Amir H Soleimani, Mary Hitt, Kamaljit Kaur, Afsaneh Lavasanifar
Traceable poly(ethylene oxide)-poly(ester) micelles were developed through chemical conjugation of a near-infrared (NIR) dye to the poly(ester) end by click chemistry. This strategy was tried for micelles with poly(ε-caprolactone) (PCL) or poly(α-benzyl carboxylate-ε-caprolactone) (PBCL) cores. The surface of both micelles was also modified with the breast cancer targeting peptide, P18-4. The results showed the positive contribution of PBCL over PCL core on micellar thermodynamic and kinetic stability as well as accumulation in primary orthotopic MDA-MB-231 tumors within 4-96 h following intravenous administration in mice...
August 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28817259/sub-20-nm-stable-micelles-based-on-a-mixture-of-coiled-coils-a-platform-for-controlled-ligand-presentation
#5
JooChuan Ang, Dan Ma, Benson Thomas Jung, Sinan Keten, Ting Xu
Ligand-functionalized, multivalent nanoparticles have been extensively studied for biomedical applications from imaging agents to drug delivery vehicles. However, the ligand cluster size is usually heterogeneous and the local valency is ill-defined. Here, we present a mixed micelle platform hierarchically self-assembled from a mixture of two amphiphilic 3-helix and 4-helix peptide-PEG-lipid hybrid conjugates. We demonstrate that the local multivalent ligand cluster size on the micelle surface can be controlled based on the coiled-coil oligomeric state...
August 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28815905/degradable-vanadium-disulfide-nanostructures-with-unique-optical-and-magnetic-functions-for-cancer-theranostics
#6
Yuyan Chen, Liang Cheng, Ziliang Dong, Yu Chao, Huali Lei, He Zhao, Jian Wang, Zhuang Liu
Multifunctional biodegradable inorganic theranostic nano-agents are of great interests to the field of nanomedicine. Herein, VS2 nanosheets upon lipid modification could be converted into ultra-small VS2 nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to the paramagnetic property, high near-infrared (NIR) absorbance, and chelator-free 99mTc4+ labeling of VS2, such VS2@lipid-PEG nanoparticles could be used for T1-weighted magnetic resonance (MR), photoacoustic (PA),and single photon emission computed tomography (SPECT) tri-modal imaging guided photothermal ablation of tumors...
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28814804/a-unique-thermo-induced-gel-to-gel-transition-in-a-ph-sensitive-small-molecule-hydrogel
#7
Hongtao Xie, Mehran Asad Ayoubi, Wensheng Lu, Jide Wang, Jianbin Huang, Wei Wang
For a hydrogel based on a zwitterionic dendritic surfactant, we report an apparently unprecedented reversible temperature-induced gel-to-gel phase transition below the melting point of its alkyl chains, where the supramolecular self-assembly of surfactant molecules underwent a dramatic transformation from low-temperature surfactant bilayers to high-temperature entangled surfactant worm-like micelles.
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813002/application-of-surfactant-micelle-entrapped-eugenol-for-prevention-of-growth-of-the-shiga-toxin-producing-escherichia-coli-in-ground-beef
#8
Tamra N Tolen, Songsirin Ruengvisesh, Thomas M Taylor
Beef safety may be compromised by O157 and non-O157 Shiga toxin-producing Escherichia coli (STEC) contamination. The capacity of surfactant micelles loaded with the plant-derived antimicrobial eugenol to reduce STEC on beef trimmings that were later ground and refrigerated for five days at 5 ± 1 °C was tested to determine their utility for beef safety protection. STEC-inoculated trimmings were treated with free eugenol, micelle-encapsulated eugenol, 2% lactic acid (55 °C), sterile distilled water (25 °C), or left untreated (control)...
August 16, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28811480/formation-pathways-of-mesoporous-silica-nanoparticles-with-dodecagonal-tiling
#9
Yao Sun, Kai Ma, Teresa Kao, Katherine A Spoth, Hiroaki Sai, Duhan Zhang, Lena F Kourkoutis, Veit Elser, Ulrich Wiesner
Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-directed mesoporous silica nanoparticle structures, including dodecagonal quasicrystalline nanoparticles, as a function of micelle pore expander concentration or stirring rate. We demonstrate that the early formation stages of dodecagonal quasicrystalline mesoporous silica nanoparticles can be preserved, where precise control of mesoporous silica nanoparticle size down to <30 nm facilitates comparison between mesoporous silica nanoparticles and simulated single-particle growth trajectories beginning with a single tiling unit...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28810752/rupturing-the-hemi-fission-intermediate-in-membrane-fission-under-tension-reaction-coordinates-kinetic-pathways-and-free-energy-barriers
#10
Guojie Zhang, Marcus Müller
Membrane fission is a fundamental process in cells, involved inter alia in endocytosis, intracellular trafficking, and virus infection. Its underlying molecular mechanism, however, is only incompletely understood. Recently, experiments and computer simulation studies have revealed that dynamin-mediated membrane fission is a two-step process that proceeds via a metastable hemi-fission intermediate (or wormlike micelle) formed by dynamin's constriction. Importantly, this hemi-fission intermediate is remarkably metastable, i...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810734/adsorption-and-depletion-regimes-of-a-nonionic-surfactant-in-hydrophilic-mesopores-an-experimental-and-simulation-study
#11
Dirk Müter, Gernot Rother, Henry Bock, Martin Schoen, Gerhard H Findenegg
Adsorption and aggregation of nonionic surfactants at oxide surfaces has been studied extensively in the past, but only for concentrations below and near the critical micelle concentration. Here we report an adsorption study of a short-chain surfactant (C6E3) in porous silica glass of different pore sizes (7.5 to 50 nm), covering a wide composition range up to 50 wt.-% in a temperature range from 20°C to the LCST. Aggregative adsorption is observed at low concentrations, but the excess concentration of C6E3 in the pores decreases and approaches zero at higher bulk concentrations...
August 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28809962/nonlinear-behavior-and-fluctuation-induced-dynamics-in-the-photosensitive-belousov-zhabotinsky-reaction
#12
Valérie Voorsluijs, Ioannis G Kevrekidis, Yannick De Decker
The photosensitive Belousov-Zhabotinsky (pBZ) reaction has been used extensively to study the properties of chemical oscillators. In particular, recent experiments revealed the existence of complex spatiotemporal dynamics for systems consisting of coupled micelles (V < 10(-21) L) or droplets (V ≈ [10(-8)-10(-11)] L) in which the pBZ reaction takes place. These results have been mostly understood in terms of reaction-diffusion models. However, in view of the small size of the droplets and micelles, large fluctuations of concentrations are to be expected...
August 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28809539/polymersomes-with-endosomal-ph-induced-vesicle-to-micelle-morphology-transition-and-a-potential-application-for-controlled-doxorubicin-delivery
#13
Turgay Yildirim, Anja Traeger, Pelin Sungur, Stephanie Hoeppener, Carolin Kellner, Ilknur Yildirim, David Pretzel, Stephanie Schubert, Ulrich S Schubert
A series of pH responsive block copolymers were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization of 3,4-dihydro-2H-pyran (DHP) protected 2-hydroxyethyl methacrylate (HEMA) (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl methacrylate (THP-HEMA)) and 2-(dimethylamino) ethyl methacrylate (DMAEMA) using p(THP-HEMA) as a macro chain transfer agent (mCTA). The degree of polymerization (DP) of the p(THP-HEMA) block was fixed to 35, whereas the DP of the p(DMAEMA) block was systematically varied from 21 to 50...
August 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28807819/carrier-characteristics-influence-the-kinetics-of-passive-drug-loading-into-lipid-nanoemulsions
#14
Katrin Göke, Heike Bunjes
Passive loading as a novel screening approach is a material-saving tool for the efficient selection of a suitable colloidal lipid carrier system for poorly water soluble drug candidates. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles after removal of excess drug. For reliable routine use and to obtain meaningful loading results, information on the kinetics of the process is required. Passive loading proceeds via a dissolution-diffusion based mechanism, where drug surface area and drug water solubility are key parameters for fast passive loading...
August 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28806698/fluorescence-and-electron-paramagnetic-resonance-studies-of-norfloxacin-and-n-donor-mixed-ligand-ternary-copper-ii-complexes-stability-and-interaction-with-sds-micelles
#15
Gabriel S Vignoli Muniz, Jimmy Llontop Incio, Odivaldo C Alves, Klaus Krambrock, Letícia R Teixeira, Sonia R W Louro
The stability of ternary copper(II) complexes of a heterocyclic ligand, L (L being 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen)) and the fluorescent antibacterial agent norfloxacin (NFX) as the second ligand was studied at pH7.4 and different ionic strengths. Fluorescence quenching upon titration of NFX with the binary complexes allowed to obtain stability constants for NFX binding, Kb, as a function of ionic strength. The Kb values vary by more than two orders of magnitude when buffer concentration varies from 0...
August 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28806519/pluronic-p85-f68-micelles-of-baicalein-could-interfere-with-mitochondria-to-overcome-mrp2-mediated-efflux-and-offer-improved-anti-parkinsonian-activity
#16
Tongkai Chen, Ye Li, Chuwen Li, Xiang Yi, Ruibing Wang, Simon Ming Yuen Lee, Ying Zheng
Overexpression of the drug efflux transporter multidrug resistance-associated protein 2 (MRP2) in the gastrointestinal tract and blood-brain barrier compromises the oral delivery of drugs to the circulation system and brain in the treatment of Parkinson's disease (PD). In this study, we aim to develop small-sized Pluronic P85/F68 micelles loaded with baicalein (B-MCs) to overcome MRP2-mediated efflux and to investigate related mechanism, as well as the anti-Parkinsonian efficacy. Spherical and sustained-release B-MCs have a mean particle size of 40...
August 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28806473/flavylium-polymethine-fluorophores-for-imaging-in-the-near-and-shortwave-infrared
#17
Emily D Cosco, Justin R Caram, Oliver T Bruns, Daniel Franke, Rachael A Day, Erik P Farr, Moungi G Bawendi, Ellen May Sletten
Bright fluorophores in the near infrared and shortwave infrared (SWIR) are essential for optical imaging in vivo. Herein, we utilize a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted polymethine dyes, with emission from 680 to 1045 nm. Photophysical characterization reveals that the 1- and 3-methine dyes display enhanced photostabilities and the 5- and 7-methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7-methine facilitates SWIR imaging in mice...
August 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28805220/revival-of-the-nearly-extinct-fluorescence-of-coumarin-6-in-water-and-complete-transfer-of-energy-to-rhodamine-123
#18
Rajashree Banerjee, Pradipta Purkayastha
The nearly extinct fluorescence of coumarin 6 in water due to microcrystal formation is revived by micelles. Practically complete transfer of energy from coumarin 6 to rhodamine 123 through resonance energy transfer could be achieved.
August 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28803731/purification-and-characterization-of-the-colicin-a-immunity-protein-in-detergent-micelles
#19
Ane Metola, Ana M Bouchet, Marian Alonso-Mariño, Tammo Diercks, Lena Mäler, Félix M Goñi, Ana R Viguera
The immunity proteins against pore-forming colicins represent a family of integral membrane proteins that reside in the inner membrane of producing cells. Cai, the colicin A immunity protein, was characterized here in detergent micelles by circular dichroism (CD), size exclusion chromatography, chemical cross-linking, nuclear magnetic resonance (NMR) spectroscopy, cysteine accessibility, and colicin A binding in detergent micelles. Bile-salt derivatives induced extensive protein polymerization that precluded further investigation...
August 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28803471/altering-the-peptide-binding-selectivity-of-polymeric-reverse-micelle-assemblies-via-metal-ion-loading
#20
Meizhe Wang, Bo Zhao, Jingjing Gao, Huan He, Laura J Castellanos, Sankaran Thayumanavan, Richard W Vachet
Supramolecular reverse micelle assemblies, formed by amphiphilic copolymers, can selectively encapsulate molecules in their interiors depending on the functional groups present in the polymers. Altering the binding selectivity of these materials typically requires the synthesis of alternate functional groups. Here, we demonstrate that the addition of Zr(IV) ions into the interiors of reverse micelles having phosphonate functional groups transforms the supramolecular materials from ones that selectively bind positively-charged peptides into materials that selectively bind phosphorylated peptides...
August 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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