keyword
MENU ▼
Read by QxMD icon Read
search

Micelle

keyword
https://www.readbyqxmd.com/read/28340485/an-approach-for-liposome-immobilization-using-sterically-stabilized-micelles-ssms-as-a-precursor-for-bio-layer-interferometry-based-interaction-studies
#1
Jakob Wallner, Gabriele Lhota, Markus Schosserer, Karola Vorauer-Uhl
Non-fluidic bio-layer interferometry (BLI) has rapidly become a standard tool for monitoring almost all biomolecular interactions in a label-free, real-time and high-throughput manner. High-efficiency screening methods which measure the kinetics of liposomes with a variety of compounds require the immobilization of liposomes. In this work, a method is described for immobilizing liposomes for interaction studies, based on the biophysical principles of this biosensor platform. The immobilization approach includes the loading of DSPE-PEG(2000)-biotin containing sterically stabilized micelles (SSMs) which are restructured in a buffer change step, resulting in an accessible substrate for liposome immobilization...
March 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28334044/in-vitro-and-in-vivo-evaluation-of-docetaxel-loaded-stearic-acid-modified-bletilla-striata-polysaccharide-copolymer-micelles
#2
Qingxiang Guan, Guangyuan Zhang, Dandan Sun, Yue Wang, Kun Liu, Miao Wang, Cheng Sun, Zhuo Zhang, Bingjin Li, Jiayin Lv
Bletilla striata polysaccharides (BSPs) have been used in pharmaceutical and biomedical industry, the aim of the present study was to explore a BSPs amphiphilic derivative to overcome its application limit as poorly water-soluble drug carriers due to water-soluble polymers. Stearic acid (SA) was selected as a hydrophobic block to modify B. striata polysaccharides (SA-BSPs). Docetaxel (DTX)-loaded SA-BSPs (DTX-SA-BSPs) copolymer micelles were prepared and characterized. The DTX release percentage in vitro and DTX concentration in vivo was carried out by using high performance liquid chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28333446/quantification-of-membrane-protein-self-association-with-a-high-throughput-compatible-fluorescence-assay
#3
Junbei Li, Xiaoyan Jade Qiu
For many membrane proteins, self-association serves both structural and functional roles. Studies of such association can be simplified by switching to micelles as the membrane-mimicking environment. But native interaction is not preserved in all detergents. The selection of suitable conditions for biochemical experiments would be greatly facilitated by a quantitative high-throughput assay. Here we showed that the fluorescence polarization (FP) reduction, resulted from homo-FRET and measured in a high-throughput compatible format, can be used to determine both association states and constants for membrane proteins in micelles...
March 23, 2017: Biochemistry
https://www.readbyqxmd.com/read/28332821/chiral-plasmonic-nanochains-via-the-self-assembly-of-gold-nanorods-and-helical-glutathione-oligomers-facilitated-by-cetyltrimethylammonium-bromide-micelles
#4
Jun Lu, Yi-Xin Chang, Ning-Ning Zhang, Ying Wei, Ai-Ju Li, Jia Tai, Yao Xue, Zhao-Yi Wang, Yang Yang, Li Zhao, Zhong-Yuan Lu, Kun Liu
Gold nanorods are excellent anisotropic building blocks for plasmonic chiral nanostructures. The near-infrared plasmonic band of nanorods makes them highly desirable for biomedical applications such as chiral bioimaging and sensing, in which a strong circular dichroism (CD) signal is required. Chiral assemblies of gold nanorods induced by self-associating peptides are especially attractive for this purpose as they exhibit plasmonic-enhanced chiroptical activity. Here, we showed that the presence of cetyltrimethylammonium bromide (CTAB) micelles in a gold nanorod solution promoted the self-association of l-/d-glutathione (GSH) and significantly enhanced the chirality of the resulting plasmonic nanochains...
March 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28331225/cholesterol-attenuates-cytoprotective-effects-of-phosphatidylcholine-against-bile-salts
#5
Yoshito Ikeda, Shin-Ya Morita, Tomohiro Terada
Bile salts have potent detergent properties and damaging effects on cell membranes, leading to liver injury. However, the molecular mechanisms for the protection of hepatocytes against bile salts are not fully understood. In this study, we demonstrated that the cytotoxicity of nine human major bile salts to HepG2 cells and primary human hepatocytes was prevented by phosphatidylcholine (PC). In contrast, cholesterol had no direct cytotoxic effects but suppressed the cytoprotective effects of PC. PC reduced the cell-association of bile salt, which was reversed by cholesterol...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327735/reverse-micelle-based-water-soluble-nanoparticles-for-simultaneous-bioimaging-and-drug-delivery
#6
Ying Chen, Yong Liu, Yongchao Yao, Shiyong Zhang, Zhongwei Gu
With special confined water pools, reverse micelles (RMs) have shown potential for a wide range of applications. However, the inherent water-insolubility of RMs hinders their further application prospects, especially for applications related to biology. We recently reported the first successful transfer of RMs from organic media to an aqueous phase without changing the smart water pools by the hydrolysis of an arm-cleavable interfacial cross-linked reverse micelles. Herein, we employed another elaborate amphiphile 1 to construct new acrylamide-based cross-linked water-soluble nanoparticles (ACW-NPs) under much gentler conditions...
March 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28325936/in-situ-gisaxs-study-of-supramolecular-nanofibers-having-ultrafast-humidity-sensitivity
#7
Arpan Bhattacharyya, Milan K Sanyal, Umesha Mogera, Subi J George, Mrinmay K Mukhopadhyay, Santanu Maiti, Giridhar U Kulkarni
Self assembled nanofibers derived from donor-acceptor (D-A) pair of dodecyl methyl viologen (DMV) and potassium salt of coronene tetracarboxylate (CS) is an excellent material for the development of organic electronic devices particularly for ultrafast response to relative humidity (RH). Here we have presented the results of in-situ grazing incidence small angle x-ray scattering (GISAXS) measurements to understand aridity dependent self reorganization of the nanofibers. The instantaneous changes in the organization of the nanofibers was monitored with different equilibrium RH conditions...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325477/nano-sized-soluplus%C3%A2-polymeric-micelles-enhance-the-induction-of-tetanus-toxin-neutralising-antibody-response-following-transcutaneous-immunisation-with-tetanus-toxoid
#8
Manolya Saydam, Woei Ping Cheng, Nathan Palmer, Robert Tierney, Robert Francis, Kirsty MacLellan-Gibson, Ambreen Khan, Fatme Mawas
The use of Soluplus® polymeric micelles as a novel adjuvant for tetanus toxoid (TTxd) in transcutaneous immunisation was evaluated. TTxd was added to Soluplus® polymeric micelles to form TTxd-Soluplus® nano-aggregates with a size of 68nm. Non-adjuvanted TTxd commonly induces very poor antibody response by the transcutaneous route. However, in this study, the use of TTxd-Soluplus® resulted in a significant increase in the antibody response to TTxd, which was similar to that induced in the presence of CPG-oligodeoxynucleotides (CPG-ODNs) adjuvant...
March 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28324920/an-open-label-randomized-parallel-phase-ii-trial-to-evaluate-the-efficacy-and-safety-of-a-cremophor-free-polymeric-micelle-formulation-of-paclitaxel-as-first-line-treatment-for-ovarian-cancer-a-korean-gynecologic-oncology-group-study-kgog-3021
#9
Shin-Wha Lee, Yong-Man Kim, Chi Heum Cho, Young Tae Kim, Seok Mo Kim, Soo Young Hur, Jae-Hoon Kim, Byoung-Gie Kim, Seung-Cheol Kim, Hee-Sug Ryu, Soon Beom Kang
Purpose: Genexol-PM is a biodegradable cremophor EL-free polymeric micelle formulation of paclitaxel. Here we compared efficacy and safety of Genexol-PM plus carboplatin vs. Genexol plus carboplatin for ovarian cancer treatment. Materials and Methods: In this multicenter, randomized, phase II study, patients with FIGO IC-IV epithelial ovarian cancer were randomly assigned (1:1) to receive Genexol-PM 260 mg/m2 or Genexol 175 mg/m2 with 5 AUC carboplatin every three weeks (6 cycles)...
March 21, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28323118/mixed-poly-vinyl-pyrrolidone-based-drug-loaded-nanomicelles-shows-enhanced-efficacy-against-pancreatic-cancer-cell-lines
#10
Anisha Veeren, Archana Bhaw-Luximon, Debabrata Mukhopadhyay, Dhanjay Jhurry
We report in this paper on the enhanced efficacy of a physical mixture of two single anti-cancer loaded nanomicelles against PANC-1 and BxPC-3. Poly(vinyl pyrrolidone-b-polycaprolactone) (PVP-b-PCL) and poly(vinyl pyrrolidone-b-poly(dioxanone-co-methyl dioxanone)) (PVP-b-P(DX-co-MeDX)) were synthesized and successfully loaded with various anti-cancer drugs - gemcitabine (GEM), doxorubicin.HCl (DOX.HCl), doxorubicin.NH2 (DOX), 5-fluorouracil (5-FU) and paclitaxel (PTX). Spherical micelles of size 160-477 nm were obtained as characterized by DLS while sizes determined by TEM were in the range 140-250 nm...
March 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28323102/preparation-of-core-crosslinked-linear-dendritic-copolymer-micelles-with-enhanced-stability-and-their-application-for-drug-solubilisation
#11
Zhengyuan Zhou, Robert T Forbes, Antony D'Emanuele
In this study we explore the preparation of core-crosslinked micelles of linear-dendritic methoxy-poly(ethylene glycol) (MPEG)-co-poly(ester-sulfide) (PES) polymers to improve the stability of such polymeric micelle systems against premature disintegration and drug release. A series of MPEG-PES copolymers were synthesised via stepwise reactions of acetylation and thiol-ene photoreaction. Surface tension measurement showed that the copolymers with ethenyl surface groups could self-associate in dilute aqueous solutions to form micelles...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28323096/nanoparticles-as-safe-and-effective-delivery-systems-of-antifungal-agents-achievements-and-challenges
#12
REVIEW
Ghareb M Soliman
Invasive fungal infections are becoming a major health concern in several groups of patients leading to severe morbidity and mortality. Moreover, cutaneous fungal infections are a major cause of visits to outpatient dermatology clinics. Despite the availability of several effective agents in the antifungal drug arena, their therapeutic outcome is less than optimal due to limitations related to drug physicochemical properties and toxicity. For instance, poor aqueous solubility limits the formulation options and efficacy of several azole antifungal drugs while toxicity limits the benefits of many other drugs...
March 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28322976/biomimetics-in-drug-delivery-systems-a-critical-review
#13
REVIEW
Mojgan Sheikhpour, Leila Barani, Alibakhsh Kasaeian
Today, the advanced drug delivery systems have been focused on targeted drug delivery fields. The novel drug delivery is involved with the improvement of the capacity of drug loading in drug carriers, cellular uptake of drug carriers, and the sustained release of drugs within target cells. In this review, six groups of therapeutic drug carriers including biomimetic hydrogels, biomimetic micelles, biomimetic liposomes, biomimetic dendrimers, biomimetic polymeric carriers and biomimetic nanostructures, are studied...
March 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28322975/a-polymeric-micelle-magnetic-resonance-imaging-mri-contrast-agent-reveals-blood-brain-barrier-bbb-permeability-for-macromolecules-in-cerebral-ischemia-reperfusion-injury
#14
Kouichi Shiraishi, Zuojun Wang, Daisuke Kokuryo, Ichio Aoki, Masayuki Yokoyama
Blood-brain barrier (BBB) opening is a key phenomenon for understanding ischemia-reperfusion injuries that are directly linked to hemorrhagic transformation. The recombinant human tissue-type plasminogen activator (rtPA) increases the risk of symptomatic intracranial hemorrhages. Recent imaging technologies have advanced our understanding of pathological BBB disorders; however, an ongoing challenge in the pre-"rtPA treatment" stage is the task of developing a rigorous method for hemorrhage-risk assessments...
March 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28322164/solubilization-and-enhancement-of-ex-vivo-vaginal-delivery-of-progesterone-using-solid-dispersions-inclusion-complexes-and-micellar-solubilization
#15
Abeer S Hassan, Ghareb M Soliman, Mona M El-Mahdy, Gamal El-Din A El-Gindy
Progesterone (PG), a natural female sex hormone is used clinically in menopausal hormone replacement therapy and to control reproductive functions. Its very limited aqueous solubility of 7 µg/ml results in reduced oral bioavailability and low patient compliance when administered in high doses. The aim of this study was to enhance PG aqueous solubility and vaginal delivery using solid dispersion, inclusion complex and micellar solubilization techniques. PG solid dispersions and inclusion complexes were prepared by solvent evaporation method using different polymers, such as cyclodextrins, polyvinyl pyrrolidone (PVP), poly (ethylene glycol) 6000, Pluronic® F-127 and Pluronic® F-68...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28322116/expanding-the-potential-of-mri-contrast-agents-through-multifunctional-polymeric-nanocarriers
#16
Ioana Craciun, Gesine Gunkel-Grabole, Andrea Belluati, Cornelia G Palivan, Wolfgang Meier
MRI is a sought-after, noninvasive tool in medical diagnostics, yet the direct application of contrast agents to tissue suffers from several drawbacks. Hosting the contrast agents in polymeric nanocarriers can solve many of these issues while creating additional benefit through exploitation of the intrinsic characteristics of the polymeric carriers. In this report, the versatility is highlighted with recent examples of dendritic and hyperbranched polymers, polymer nanoparticles and micelles, and polymersomes as multifunctional bioresponsive nanocarriers for MRI contrast agents...
March 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28321452/spontaneous-wormlike-micelles-formed-in-a-single-tailed-zwitterionic-surface-active-ionic-liquid-aqueous-solution
#17
Panpan Sun, Fei Lu, Aoli Wu, Lijuan Shi, Liqiang Zheng
Wormlike micelles were successfully fabricated by the self-assembly of a single-tailed zwitterionic surface-active ionic liquid (SAIL), 3-(1-hexadecyl-3-imidazolio) propanesulfonate β-naphthalene sulfonate (C16IPS-Nsa), in aqueous solutions without any additives. With increasing zwitterionic SAIL concentration, spontaneous transition from micelles to wormlike micelles and then a hexagonal phase occurs. Interestingly, the wormlike micelles are closed, stretched and directionally arranged, which was rarely found in previous research studies...
March 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28319361/block-copolymer-templated-hierarchical-porous-carbon-nanostructures-with-nitrogen-rich-functional-groups-for-molecular-sensing
#18
Ya-Sen Sun, Chien-Fu Lin, Shih-Ting Luo, Ching-Yuan Su
The self-assembly of a block copolymer offers access to micellar nanodomains with tunable dimensions and structural diversity through control of such molecular parameters as the volume fraction and molecular mass. We fabricated hierarchical porous carbon (HPC) nanostructures with bundles of aggregated nanospheres and with nitrogen-rich functional groups through pyrolysis of diblock copolymer micelles in multiple layers. The resultant HPC nanostructures with a considerable specific surface area serve as an excellent substrate for surface-enhanced Raman spectroscopy (SERS), coupled with fluorescence quenching, for molecular sensing of physically adsorbed Rhodamine 6G...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28317987/when-self-assembly-meets-topology-an-enhanced-micelle-stability
#19
Xiaopeng Dong, Xuliang Guo, Guangqin Liu, Aiping Fan, Zheng Wang, Yanjun Zhao
The topology of hydrophobic moieties can affect the stability of self-assembled micelles. Curved corannulene and flat perylene were selected as model hydrophobic molecules with poly(ethylene glycol) as the hydrophilic segment. The curvature can enhance the intermolecular π-π interaction, and hence the driving force of micelle formation.
March 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28317770/characterization-enhancement-and-modelling-of-mannosylerythritol-lipid-production-by-fungal-endophyte-ceriporia-lacerate-chzju
#20
Yongwu Niu, Linlin Fan, Di Gu, Jianan Wu, Qihe Chen
The glycolipid biosurfactants mannosylerythritol lipids (MELs) attract great attention for their biodegradability, super emulsifying properties and versatile bioactivities. In this study, the MEL deriving from Ceriporia lacerate CHZJU was identified as MEL-A, and its critical micelle concentration and emulsifying activities were assessed. To examine the production of MELs from Ceriporia lacerate, a Plackett-Burman design and response surface methodology were used to optimize the culture nutrients. The optimal medium contains 1g/L yeast extract, 1...
August 1, 2017: Food Chemistry
keyword
keyword
56695
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"