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Daniel Timothy Bowron, Karen J Edler
Wide-angle neutron scattering experiments combined with Empirical Potential Structural Refinement modelling have been used to study the detailed structure of decyltrimethylammonium bromide micelles in the presence of acid solutions of HCl or HBr. These experiments demonstrate considerable variation in micelle structure and water structuring between micelles in the two acid solutions and in comparison with the same micelles in pure water. In the presence of the acids, the micelles are smaller, however in the presence of HCl the micelles are more loosely structured and disordered while in the presence of HBr the micelles are more compact and closer to spherical...
December 9, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Guohua Xu, Kai Cheng, Qiong Wu, Maili Liu, Conggang Li
Many cellular reactions involving proteins, including their biosynthesis, misfolding, and transport, occur in confined compartments. Despite its importance, a structural basis of understanding of how confined environments alter protein function is still lacking. Herein, we explore structure-function correlations of calmodulin (CaM), a multidomain protein involved in many calcium-mediated signaling pathways, in reverse micelles. Confinement dramatically alters CaM structure and function. The protein forms an extended structure in bulk water, but becomes compacted in reverse micelles...
December 9, 2016: Angewandte Chemie
Sijia Yi, Sean David Allen, Yu-Gang Liu, Brian Zhou Ouyang, Xiaomo Li, Punn Augsornworawat, Edward Benjamin Thorp, Evan Alexander Scott
Atherosclerosis, a leading cause of heart disease, results from chronic vascular inflammation that is driven by diverse immune cell populations. Nanomaterials may function as powerful platforms for diagnostic imaging and controlled delivery of therapeutics to inflammatory cells in atherosclerosis, but efficacy is limited by nonspecific uptake by cells of the mononuclear phagocytes system (MPS). MPS cells located in the liver, spleen, blood, lymph nodes, and kidney remove from circulation the vast majority of intravenously administered nanomaterials regardless of surface functionalization or conjugation of targeting ligands...
December 9, 2016: ACS Nano
Gergana S Georgieva, Svetoslav E Anachkov, Ingo Lieberwirth, Kaloian Koynov, Peter A Kralchevsky
The synergistic growth of giant wormlike micelles in ternary mixed solutions composed of an anionic surfactant (sodium laurylethersulfate, SLES), a zwitterionic surfactant (cocamidopropyl betaine, CAPB), and octanoic acid (HC8) is studied. Rheological data and their analysis in terms of Cole-Cole plots and micellar characteristic times are presented, and the micellar structures behind the observed rheological behavior are revealed by cryo-TEM micrographs. The surfactant composition is fixed near the maximal micelle size of the binary SLES + CAPB system, whereas the concentration of HC8 is varied...
December 6, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Chi M Phan, Cuong V Nguyen, Hiromichi Nakahara, Osamu Shibata, Thanh V Nguyen
The ionic state of an adsorbed gemini surfactant at the air/water interface was investigated using a combination of surface potential and surface tension data. The combined model was developed and successfully described the experimental data. The results verified the existence of three ionic states of the gemini surfactant in the interfacial zone. Furthermore, the model can quantify the adsorbed concentrations of these species. At low concentrations, the fully dissociated state dominates the adsorption. At high concentrations, the fully associated state dominates, accounting for up to 80% of the total adsorption...
December 6, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Adeel Masood Butt, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Nor Azian Abdul Murad, Rahman Jamal, Prashant Kesharwani
This study investigated the potential of chitosan-coated mixed micellar nanocarriers (polyplexes) for codelivery of siRNA and doxorubicin (DOX). DOX-loaded mixed micelles (serving as cores) were prepared by thin film hydration method and coated with chitosan (CS, serving as outer shell), and complexed with multidrug resistance (MDR) inhibiting siRNA. Selective targeting was achieved by folic acid conjugation. The polyplexes showed pH-responsive enhanced DOX release in acidic tumor pH, resulting in higher intracellular accumulation, which was further augmented by downregulation of mdr-1 gene after treatment with siRNA-complexed polyplexes...
December 5, 2016: Molecular Pharmaceutics
Dien Ngo, Steven Baldelli
Adsorption of dimethyldodecylamine oxide (DDAO) and its mixtures with Triton X-100 (TX-100) at the hydrophilic silica/water interface has been studied using total internal reflection (TIR) Raman spectroscopy and target factor analysis (TFA). The use of a linear vibrational spectroscopic technique helps obtain information on molecular behavior, adsorbed amount, and conformational order of surfactant molecules at the interface. The results obtained from polarized Raman measurements of pure DDAO show insignificant changes in the orientation and conformational order of surface molecules as a function of DDAO bulk concentrations...
December 8, 2016: Journal of Physical Chemistry. B
Na Liu, Yanan Tan, Yingwen Hu, Tingting Meng, Lijuan Wen, Jingwen Liu, Bolin Cheng, Hong Yuan, Xuan Huang, Fuqiang Hu
Redox-responsive nanomaterials applied in drug delivery systems (DDS) have attracted an increasing attention in pharmaceutical research as a carrier for antitumor therapy. However, there would be unwanted drug release from a redox-responsive DDS with no selection at nontarget sites, leading to undesirable toxicities in normal tissues and cells. Here, an A54 peptide modified and PEGylated reduction cleavable glucolipid conjugate (A54-PEG-CSO-ss-SA, abbreviated to APCssA) was designed for intracellular delivery of doxorubicin (DOX)...
December 7, 2016: ACS Applied Materials & Interfaces
Sabyasachi Chatterjee, Gopinatha Suresh Kumar
Palmatine and berberine, imperative isoquinoline alkaloids, have many potential therapeutic uses. We visualized the stepwise complex formation between these alkaloids and sodium dodecyl sulfate (SDS), a known anionic surfactant characterizing alkaloid-induced SDS micelle formation at different stages. UV-visible spectra directly divulged the complex formation at different stages, and this was supported by the fluorescence emission spectral and fluorescence anisotropy data. Fluorescence quenching experiments precisely located the alkaloid molecules in the micellar environment above the critical micelle concentration (CMC)...
November 17, 2016: Journal of Physical Chemistry. B
Vitaly S Kravchenko, Igor I Potemkin
We performed computer simulations to reveal a difference in internal structures of micelles formed by AB gradient copolymers and equivalent diblock copolymers in a selective solvent. In contrast to distinct core-shell structure of the diblock copolymer micelles (DCM), the soluble and insoluble monomer units are less segregated in the gradient copolymer micelles (GCM). Furthermore, the concentration of the soluble units in the GCM has a maximum at the core-corona interface. The maximum is a consequence of loop formation near the interface due to the broad distribution of the insoluble units along the chain and their assembly into the core of the micelle...
December 1, 2016: Journal of Physical Chemistry. B
Sanket J Joshi, Yahya M Al-Wahaibi, Saif N Al-Bahry, Abdulkadir E Elshafie, Ali S Al-Bemani, Asma Al-Bahri, Musallam S Al-Mandhari
The biosurfactant production by Bacillus licheniformis W16 and evaluation of biosurfactant based enhanced oil recovery (EOR) using core-flood under reservoir conditions were investigated. Previously reported nine different production media were screened for biosurfactant production, and two were further optimized with different carbon sources (glucose, sucrose, starch, cane molasses, or date molasses), as well as the strain was screened for biosurfactant production during the growth in different media. The biosurfactant reduced the surface tension and interfacial tension to 24...
2016: Frontiers in Microbiology
Hao Wu, Qingxiang Zhong, Rongling Zhong, Houcai Huang, Zhi Xia, Zhongcheng Ke, Zhenhai Zhang, Jie Song, Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration...
2016: International Journal of Nanomedicine
Xiangning Liu, Ye Zhang, Shaobing Li, Yayu Wang, Ting Sun, Zejian Li, Lizhao Cai, Xiaogang Wang, Lei Zhou, Renfa Lai
New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in titania nanotube (TNT) arrays, and a bone-targeting Ti implant-bone interface was also successfully constructed by implanting the delivery system in vivo...
2016: International Journal of Nanomedicine
Zhenhua Fang, Yanpeng Sun, Hong Xiao, Peng Li, Ming Liu, Fan Ding, Wusheng Kan, Runsheng Miao
Osteosarcoma is the most common primary malignant bone tumor in the pediatric age group, and chemotherapy directed by targeted nanoparticulate drug delivery system represents a promising approach for osteosarcoma treatment recently. Here, we designed and developed a novel DOX-loaded targeted polymeric micelle self-assembled from RGD-terminated poly(ethylene glycol)-block-poly (trimethylene carbonate) (RGD-PEG-PTMC) amphiphilic biodegradable block copolymer, for high-efficiency targeted chemotherapy of osteosarcoma...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Simon Sauvé, Yves Aubin
A peptide encompassing the conserved hydrophobic region and the first β-strand of the prion protein (PrP(110-136)) shown to interact with the surface of dodecylphosphocholine micelles adopts an α-helical conformation that is localized below the head-group layer. This surface-bound peptide has a half-life of one day, and readily initiates the formation of amyloid fibrils. The presence of the latter was confirmed using birefringence microscopy upon Congo red binding and thioflavin T-binding induced fluorescence...
2016: PloS One
D Gaudino, R Pasquino, J Stellbrink, N Szekely, M Krutyeva, A Radulescu, W Pyckhout-Hintzen, N Grizzuti
The micellar system based on cetylpyridinium chloride (CPyCl) and sodium salicylate (NaSal) in brine solution is investigated on both macro- and micro-length scales through rheology and scattering measurements. The linear viscoelasticity of the system and its structural parameters are explored by systematically changing the amount of NaSal over an extremely wide range of concentrations, thus producing salt-to-surfactant molar ratios from zero to about 8.5. As a result, the well-known non-monotonic behaviour of the zero-shear rate viscosity as a function of salinity can be connected to micellar morphological changes, whose driving force is represented by the simultaneous binding and screening actions of NaSal...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
Matthew M Sartin, Kei Kondo, Michito Yoshizawa, Satoshi Takeuchi, Tahei Tahara
The local environment within a recently developed anthracene-shelled micelle (ASM), which is a micelle-like nanocapsule composed of anthracene-embedded amphiphiles, was investigated by steady-state and time-resolved spectroscopy of an encapsulated solvatochromic fluorescent probe molecule, coumarin 153 (C153). The absorption maximum of encapsulated C153 (452 nm) is more red-shifted than that of free C153 in water, indicating a highly polar environment inside the micelle. Despite this, the fluorescence Stokes shift of encapsulated C153 (∼3700 cm(-1)) is substantially smaller than that of free C153 in water...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
Ikuo Ikeda, Kyouhei Tamakuni, Tomomi Sakuma, Ran Ozawa, Nao Inoue, Yuka Kishimoto
Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD...
2016: Journal of Nutritional Science and Vitaminology
Kae Inagaki, Yuuki Nishimura, Emiko Iwata, Sachinobu Manabe, Masahiro Goto, Yoshio Ogura, Hisako Hotta
By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol...
2016: Journal of Nutritional Science and Vitaminology
Li-Chun Cheng, Yan Jiang, Yu Xie, Lu-Lu Qiu, Qing Yang, Hui-Yi Lu
In order to decrease the toxicity of paclitaxel (PTX) and increase the efficiency, we developed an amphiphilic PTX injection system using a biodegradable and biocompatible polymer synthesized by folic acid, cholesterol, and chitosan (FACC). This FACC-based polymer had a low critical concentration (64.13μg/ml) and could self-assemble in aqueous condition to form nanoscale micelles. The particle sizes of FACC-PTX micelles were 253.2±0.56 nm, the encapsulation efficiency and loading capacity of these FACC-PTX micelles were 65...
December 1, 2016: Oncotarget
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