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Yi Shu, Hongran Yin, Mehdi Rajabi, Hui Li, Mario Vieweger, Sijin Guo, Dan Shu, Peixuan Guo
RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures for biotechnological and biomedical applications. In addition to current self-assembly strategies utilizing base pairing, motif piling and tertiary interactions, we reported for the first time to build RNA based micellar nanoconstruct with a cholesterol molecule conjugated onto one helical end of a branched pRNA three-way junction (3WJ) motif. The resulting amphiphilic RNA micelles consist of a hydrophilic RNA head and a covalently linked hydrophobic lipid tail that can spontaneously assemble in aqueous solution via hydrophobic interaction...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Cristina Núñez, Sergio Vázquez Estévez, María Del Pilar Chantada
Nanoparticles are being actively developed for biomolecular profiling of cancer biomarkers, tumor imaging in vivo, and targeted drug delivery. These nanotechnology-based techniques can be applied widely in the management of different malignant diseases, such as breast cancer. Although the number of different types of nanoparticles is increasing rapidly, most can be classified into two major types: particles that contain organic molecules as a major building material (such as dendrimers, micelles, liposomes and carbon nanotubes, and other polymers); and those that use inorganic elements, usually metals, as a core...
February 16, 2018: Journal of Biological Inorganic Chemistry: JBIC
Cihui Tian, Sajid Asghar, Yurui Xu, Zhipeng Chen, Mei Zhang, Lin Huang, Junxiu Ye, Qineng Ping, Yanyu Xiao
In this study, a redox-sensitive glioma-targeting micelle system was designed to deliver curcumin (CUR) by conjugating it to hyaluronic acid (HA-s-s-CUR, HSC) via disulfide linkage. The effect of the molecular weight of HA on the physicochemical characteristics of HSC conjugates and their in vitro effects in glioma cells were also explored. These conjugates formed nano-scale micelles (209-926 nm) independently in aqueous solution. The micelles greatly increased the solubility of CUR and improved its stability, which is crucial for harnessing the therapeutic potential of this active molecule...
February 11, 2018: Colloids and Surfaces. B, Biointerfaces
Boxuan Ma, Weihua Zhuang, Yanan Wang, Rifang Luo, Yunbing Wang
Intelligent drug delivery systems with prolonged circulation time, reduced drug leakage in blood, target site-triggered drug release and endosomal escape are attractive and ideal for malignant tumor therapy. Herein, doxorubicin (DOX)-conjugated smart polymeric micelles based on 4-carboxy benzaldehyde-grafted poly (L-lysine)-block-poly (methacryloyloxyethyl phosphorylcholine) (PLL(CB/DOX)-b-PMPC) copolymer are prepared. DOX and electronegative 4-carboxy benzaldehyde are conjugated to the PLL block via an imine linkage and as a result, the drug loaded micelles exhibited the pH-triggered charge-conversion property and accelerated drug release at tumor pH...
February 13, 2018: Acta Biomaterialia
Praful Nair, Cory Alvey, Xiaoling Jin, Jerome Irianto, Irena Ivanovska, Dennis E Discher
Drug resistance and relapse is common in cancer treatments with chemotherapeutics, and while drug combinations with naturally occurring, differentiation-inducing retinoic acid (RA) are highly successful against one type of liquid tumor, solid tumors present major problems for delivery. Here, inspired by filoviruses that can be microns in length, flexible filomicelles that self-assemble from an amphiphilic block copolymer (PEG-PCL) are shown to effectively deliver RA and paclitaxel (TAX) to several solid tumor models, particularly in liver...
February 16, 2018: Bioconjugate Chemistry
Reju George Thomas, Myeong Ju Moon, Suchithra Poilil Surendran, Hyeong Ju Park, In-Kyu Park, Byeong-Il Lee, Yong Yeon Jeong
PURPOSE: Paclitaxel (PTX) loaded hydrophobically modified glycol chitosan (HGC) micelle is biocompatible in nature, but it requires cancer targeting ability and stimuli release property for better efficiency. To improve tumor retention and drug release characteristic of HGC-PTX nanomicelles, we conjugated cancer targeting heptamethine dye, MHI-148, which acts as an optical imaging agent, targeting moiety and also trigger on-demand drug release on application of NIR 808 nm laser. PROCEDURES: The amine group of glycol chitosan modified with hydrophobic 5β-cholanic acid and the carboxyl group of MHI-148 were bonded by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide chemistry...
February 15, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Elena Tajuelo Rodriguez, Lawrence M Anovitz, Caleb D Clement, Adam J Rondinone, Michael C Cheshire
Diopside is a common natural pyroxene that is rarely found in a pure state, since magnesium is often partially substituted by iron, and other elements (sodium and aluminum) are often present. This pyroxene, along with feldspars and olivines, is common in concrete. As the prospective license renewal of light water reactors to 80 years of operation has raised concerns on the effects of radiation in the concrete biological shield surrounding the reactors, mineral nanoparticles can be valuable to perform amorphization studies to inform predictive models of mechanical properties of irradiated concrete...
February 15, 2018: Scientific Reports
Manpreet Singh, Vandana Thakur, Rahul Deshmukh, Amit Sharma, M S Rathore, Ajay Kumar, Neeraj Mishra
The aim of this study was to prepare and characterize oral delivery of Morin hydrate loaded micellar nanocarriers using Pluronic P127 & Pluronic F123 for the effective management of Alzheimer's disease. After administration of formulation brain and blood drug concentration were found to be highest for optimized morin hydrate loaded micellar nanocarriers as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate loaded micellar nanocarriers as compared to disease control group...
February 16, 2018: Journal of Microencapsulation
Min Li, Li Lv, Aijie Guo, Yuanyuan Shen, Shengrong Guo
Curcumin (Cur) has potent antitumor activity; however, its clinical use is limited due to its hydrophobicity and instability at physiological pH. In this work, Cur was incorporated into MPEG2K-P(CL-co-LLA) micelles to form the Cur-loaded micelles with drug loadings from 4.72% to 35.21% depending on the ratios of drug to MPEG2K-P(CL-co-LLA). The resulting Cur-loaded micelles were spherical with mean hydrodynamic diameters in the range of 28.8 to 58.6 nm, having excellent water-solubility and good stability at pH 7...
March 1, 2018: Journal of Nanoscience and Nanotechnology
S Wołoszczuk, M Banaszak
We investigate triblock-homopolymer blends of types A1BA2/A and A1BA2/B, using a lattice Monte Carlo method. While the simulated triblock chains are compositionally symmetric in terms of the A-to-B volume ratio, the A1 block is significantly shorter than the A2 block. For the pure A1BA2 melt and the A1BA2 solutions in selective solvent the phase behavior is relatively well known, including existence and stability of the interstitial micelles which were discovered in previous Monte Carlo simulations. In this paper we study the stability of the interstitial micelles as a function of triblock volume fraction in selective homopolymers of either type A or type B, using two significantly different homopolymer chain lengths...
January 2018: Physical Review. E
Jin-Ping Zha, Meng-Ting Zhu, Li Qin, Xin-Hong Wang
The interactions between Orange G (OG) with three kinds of ionic liquid surfactants (C 10 mimBF 4 , C 12 mimBF 4 , C 16 mimBF 4 ) and CTAB were studied with UV-Vis spectra and conductivity measurements. The systematic changes in UV-Vis spectra with an increase of carbon-chain length may be observed in presence of OG. They correspond to CMC of every system, respectively, and the CMCs of four systems have exhibit the decrease of CMCs compared to pure surfactant. The binding constants are calculated from the results of conductivity measurements in the order of C 16 mimBF 4 >CTAB>C 12 mimBF 4 >C 10 mimBF 4 ...
February 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Débora V C Mendonça, Vívian T Martins, Daniela P Lage, Daniel S Dias, Patrícia A F Ribeiro, Ana Maria R S Carvalho, Anna Letícia T Dias, Carolina K Miyazaki, Daniel Menezes-Souza, Bruno M Roatt, Carlos A P Tavares, José Mário Barichello, Mariana C Duarte, Eduardo A F Coelho
Amphotericin B (Amp) has been well-successfully used to treat against Leishmania infection, although high toxicity has been found in patients. In the present study, Amp was administered in Leishmania infantum-infected BALB/c mice by three distinct delivery systems aiming to compare their efficacy against challenge infection, as well as their side effects in a murine visceral leishmaniasis (VL) model. This product was administered in a Poloxamer P407 (Pluronic ® F127)-based polymeric micelle system (Amp/M), in the Ambisome ® formulation (Lip-Amp) or in a free format (free Amp)...
February 12, 2018: Experimental Parasitology
Joon Seon Yang, Juan Qiao, Jin Yong Kim, Liping Zhao, Li Qi, Myeong Hee Moon
In this paper, we have reported a fully automated on-line method to carry out proteolysis and glycopeptide enrichment in sequence for nanoflow liquid chromatography-tandem mass spectrometry (nLC-ESI-MS/MS) analysis. By implementing two serial thermo-responsive porous polymer membrane reactors (TPPMRs), in which the TPPM could be immobilized either with trypsin for proteolysis or with lectins for glycopeptide enrichment, the entire pre-treatment procedure can be performed on-line in about an hour. The TPPM was fabricated by coating polystyrene-maleic anhydride-N-isopropylacrylamide (PS-MAn-PNIPAm), which was synthesized by reversible addition-fragmentation chain transfer polymerization, on a Nylon sheet...
February 15, 2018: Analytical Chemistry
Aoli Wu, Xinpei Gao, Panpan Sun, Fei Lu, Liqiang Zheng
Gelation mechanism is of utmost importance to the rational design of supramolecular hydrogelators. Although both kinetic and thermodynamic controlling self-assembly processes have been widely studied in hydrogels, the evolution relationship between crystalline and amorphous gel networks still remains ambiguous. Herein, a gelation transformation from kinetic to thermodynamic process was achieved by balancing the rigidity and flexibility of the inorganic-organic co-assemblies. And for the first time, the transition morphologies between crystalline and amorphous hydrogel networks were evidenced as ordered wormlike micelles...
February 15, 2018: Angewandte Chemie
Jing Lin, Chaoyue Zhao, Cuijuan Liu, Shiyao Fu, Luying Han, Xinping Lu, Chunrong Yang
Introduction: The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR). Materials and methods: This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity...
2018: International Journal of Nanomedicine
Elias Pambou, Xuzhi Hu, Zongyi Li, Mario Campana, Arwel Hughes, Peixun Li, John Robert Peter Webster, Gordon Bell, Jian Ren Lu
The interaction of nonionic surfactant hexaethylene glycol monododecyl ether (C12E6) with a reconstituted cuticular wheat wax film has been investigated by spectroscopic ellipsometry (SE) and neutron reflection (NR) to help understand the role of the leaf wax barrier during pesticide uptake, focusing on the mimicry of the actions adjuvants impose on the physical integrity and transport of the cuticular wax films against surfactant concentration. As C12E6 concentration was increased up to the critical micelle concentration (CMC = 0...
February 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Manu Sharma, Ashish Kumar, Rajeev K Gautam, Mamta Belwal
ZnO-CeO2 nanocomposite was synthesized by co-precipitation and reverse micelle methods, which show rod-shaped morphologies. In co-precipitation method, the nanocomposite has uniform rodshaped structure, whereas in reverse micelle method rods like structures are made up of spherical shaped nanoparticles. The photocatalytic dye degradation of rhodamine-B (RhB) has been examined using ZnO-CeO2 nanocomposite at room temperature. The photodegradation rates of catalysts in co-precipitation and reverse micelle methods were observed as 0...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Hong-Liang Gong, Lei Lei, Shu-Xian Shi, Yu-Zheng Xia, Xiao-Nong Chen
In this work, polylactide-b-poly(N-isopropylacrylamide) were synthesized by the combination of controlled ring-opening polymerization and reversible addition fragmentation chain transfer polymerization. These block copolymers with molecular weight range from 7,900 to 12,000 g/mol and narrow polydispersity (≤1.19) can self-assemble into micelles (polylactide core, poly(N-isopropylacrylamide) shell) in water at certain temperature range, which have been evidenced by laser particle size analyzer proton nuclear magnetic resonance and transmission electron microscopy...
May 1, 2018: Journal of Nanoscience and Nanotechnology
John A Carver, Heath Ecroyd, Roger J W Truscott, David C Thorn, Carl Holt
Molecular chaperone proteins perform a diversity of roles inside and outside the cell. One of the most important is the stabilization of misfolding proteins to prevent their aggregation, a process that is potentially detrimental to cell viability. Diseases such as Alzheimer's, Parkinson's, and cataract are characterized by the accumulation of protein aggregates. In vivo, many proteins are metastable and therefore under mild destabilizing conditions have an inherent tendency to misfold, aggregate, and hence lose functionality...
February 14, 2018: Accounts of Chemical Research
Behzad Sharif Makhmalzade, Fateme Chavoshy
The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its vehicle with the skin layers. In this review, an overview of skin structure and feature of polymeric micelles as topical nanocarriers is provided. We also summarized the research studies dealing with the application of polymeric micelles for cutaneous delivery...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
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