keyword
MENU ▼
Read by QxMD icon Read
search

Micelle

keyword
https://www.readbyqxmd.com/read/29031154/thermally-stable-microemulsions-comprising-imidazolium-based-surface-active-ionic-liquids-non-polar-ionic-liquid-and-ethylene-glycol-as-polar-phase
#1
Manvir Kaur, Gurbir Singh, Sandeep Kumar, Navnidhi, Tejwant Singh Kang
Ionic liquid (IL), 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, [C2mim] [Tf2N], as a non-polar phase in conjunction with polar ethylene glycol (EG) forms microemulsions stabilized by surface active ionic liquids (SAILs), N-methyl-N-alkylimidazolium chlorides, [Cnmim] [Cl], where n = 8, 12 and 16 in conjunction with decanol as co-surfactant. The phase behaviour of the ternary systems has been investigated and three regions of microemulsions - polar-in-ionic liquid, bicontinuous and ionic liquid-in-polar, have been identified using electrical conductivity measurements...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29031133/nmr-diffusometry-data-sampling-optimization-for-mixture-analysis
#2
Florence Franconi, Laurent Lemaire, Benjamin Siegler, Jean-Christophe Gimel, Patrick Saulnier
NMR diffusometry is a powerful but challenging method to analyze complex mixture. Each component diffuses differently, from the faster small species to the slower large species, corresponding to different signal attenuation. However, the method is highly sensitive to the quality of the acquired data and the performance of the processing used to resolve multiexponential signals influences. Adapting the signal decay sampling to the mixture composition is one way to improve the precision of the measure. In this work, we propose a prediction tool, based on the calculation of the Cramér-Rao lower bound to minimize the variance of diffusion coefficient estimation in order to determine the optimal number of diffusion gradient steps, the best diffusion gradient sampling (among linear, exponential, quadratic and sigmoidal ones) and the optimal maximum diffusion factor...
October 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29031092/one-step-synthesis-of-silicon-carbide-foams-supported-hierarchical-porous-sludge-derived-activated-carbon-as-efficient-odor-gas-adsorbent
#3
Jingling Yang, Wenjun Xu, Chun He, Yajing Huang, Zaili Zhang, Yunchen Wang, Lingling Hu, Dehua Xia, Dong Shu
Hierarchical porous sludge-derived activated carbon coated on macroporous silicon carbide (SiC) foams substrate has been facilely fabricated via a simple one-step strategy by utilizing sludge as carbon source, and jointly using zinc chloride and hexadecanol as pore forming agents. The sludge-derived carbon has been confirmed to be hierarchical macro-meso-microporous structure based on detailed characterization by scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman spectra and nitrogen adsorption-desorption measurement...
October 2, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29028605/the-construction-and-characterization-of-hybrid-paclitaxel-in-micelle-in-liposome-systems-for-enhanced-oral-drug-delivery
#4
Yimu Li, Zheng Chen, Yanan Cui, Guangxi Zhai, Lingbing Li
In this study, novel paclitaxel (PTX) loaded hybrid liposomes for oral PTX delivery were prepared through incorporating PTX loaded polyion complex micelles comprised of positively charged Pluronic F127-Polyethylenimine (PF127-PEI) copolymer and negatively charged sodium cholate (CA) into liposomes consisted of phospholipid molecules. According to the results, this kind of PTX-loaded hybrid liposomes showed improved PTX encapsulation efficiency, sustained PTX release, and enhanced PTX absorption in intestine...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29028506/sodium-deoxycholate-mediated-enhanced-solubilization-and-stability-of-hydrophobic-drug-clozapine-in-pluronic-micelles
#5
Pankaj Singla, Onkar Singh, Shruti Chabba, V K Aswal, Rakesh Kumar Mahajan
In this report, the solubilization behaviour of a hydrophobic drug Clozapine (CLZ) in micellar suspensions of pluronics having different hydrophilic lipophilic balance (HLB) ratios viz. P84, F127 and F108 in the absence and presence of bile salt sodium deoxycholate (SDC) has been studied. UV-Vis spectroscopy has been exploited to determine the solubilization capacity of the investigated micellar systems in terms of drug loading efficiency, average number of drug molecules solubilized per micelle (ns), partition coefficient (P) and standard free energy of solubilization (∆G(°))...
October 7, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29028356/aggregation-of-a-cationic-gemini-surfactant-with-a-chelating-molecule-and-effects-from-calcium-ion
#6
Weiwei Zhao, Kai Song, Yao Chen, Hua Wang, Zhang Liu, Qiang Shi, Jianbin Huang, Yilin Wang
The aggregation behavior of a cationic ammonium gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12) with a chelating molecule ethylenediaminetetraacetic acid (EDTA) and the effects of calcium bromide (CaBr2) on the structure and morphology of the aggregates in the mixture have been investigated by surface tension, isothermal titration microcalorimetry, electrical conductivity, ζ potential, dynamic light scattering, cryogenic transmission electron microscopy, freeze-fracture transmission electron microscopy and 1H NMR techniques...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29028299/environmental-engineering-of-pd-nanoparticle-catalysts-for-catalytic-hydrogenation-of-co2-and-bicarbonate
#7
Li-Chen Lee, Xiaoyu Xing, Yan Zhao
The extraordinary catalytic properties of enzymes are derived not only from their catalytic groups but also the unique properties of the active site. Tuning the microenvironment of synthetic catalysts is expected to enhance their performance if effective strategies can be developed. Interfacially cross-linked reverse micelles were prepared from three different cross-linkable surfactants. Pd nanoparticles were deposited in the core of the micelle for the catalytic hydrogenation of bicarbonate and CO2. The catalytic performance was found to depend heavily on the nature of the headgroup of the surfactant...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29027132/submicrometer-emitter-esi-tips-for-native-mass-spectrometry-of-membrane-proteins-in-ionic-and-nonionic-detergents
#8
Anna C Susa, Jennifer L Lippens, Zijie Xia, Joseph A Loo, Iain D G Campuzano, Evan R Williams
Native mass spectrometry (native-MS) of membrane proteins typically requires a detergent screening protocol, protein solubilization in the preferred detergent, followed by protein liberation from the micelle by collisional activation. Here, submicrometer nano-ESI emitter tips are used for native-MS of membrane proteins solubilized in both nonionic and ionic detergent solutions. With the submicrometer nano-ESI emitter tips, resolved charge-state distributions of membrane protein ions are obtained from a 150 mM NaCl, 25 mM Tris-HCl with 1...
October 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29025675/acetal-linked-pegylated-paclitaxel-prodrugs-forming-free-paclitaxel-loaded-ph-responsive-micelles-with-high-drug-loading-capacity-and-improved-drug-delivery
#9
Da Huang, Yaping Zhuang, Hong Shen, Fei Yang, Xing Wang, Decheng Wu
Endosomal pH-responsive micellar nanoparticles were prepared by self-assembly of an amphiphilic poly(ethylene glycol)-acetal-paclitaxel (PEG-acetal-PTX) prodrug, and free PTX could be encapsulated in the hydrophobic core of the nanoparticles. These nanoparticles exhibited excellent storage stability for over 6months under normal conditions, but disassembled quickly in response to faintly acidic environment. Incorporating physical encapsulation and chemical conjugation, the PTX concentration in the nanoparticles solution could reach as high as 3665μg/mL, accompanying with a high drug loading capacity of 60...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025673/effects-of-cetyltrimethylammonium-bromide-on-the-morphology-of-green-synthesized-fe3o4-nanoparticles-used-to-remove-phosphate
#10
Li Gan, Zeyang Lu, Dan Cao, Zuliang Chen
In this paper, iron oxide nanoparticles (IONPs) are successfully synthesized using Eucalyptus leaf extract in the presence of cetyltrimethylammonium bromide (CTAB) to enhance the dispersion and reduce aggregation of IONPs. CTAB was used as a stabilizing and capping agent in biosynthesis of IONP was observed. The particle size decreased from 183.9±30.1nm to 89.8±17.1nm as the concentration of CTAB increased from 0 to 0.4mM CTAB, indicating that CTAB reduce the aggregation of IONPs and enhance the reactivity...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025653/stepwise-ph-reduction-responsive-polymeric-conjugates-for-enhanced-drug-delivery-to-tumor
#11
Shudi Yang, Ying Wang, Zhaoxiang Ren, Mengtian Chen, Weiliang Chen, Xuenong Zhang
In this research, a charge-conversional polymer, poly-l-lysine-lipoic acid (PLL-LA), was prepared by dimethylmaleic anhydride (DA) modification and applied as a carrier with enhanced cell internalization and intracellular pH- and reduction-triggered doxorubicin (Dox) release. The surface charge of dimethylmaleic anhydride-poly-l-lysine-lipoic acid micelles (DA-PLL-LA) was negative at physiological pH and reversed to positive at the extracellular and intracellular pH of cancer cells. At tumor extracellular pH of 6...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025636/folic-acid-grafted-and-tertiary-amino-based-ph-responsive-pentablock-polymeric-micelles-for-targeting-anticancer-drug-delivery
#12
Quan Chen, Jiewei Zheng, Xiaozhe Yuan, Jufang Wang, Lijuan Zhang
Increasing target to tumor sites and reducing accumulation at normal tissue sites of anticancer drugs are essential to improve the cancer chemotherapy efficiency. In this study, we have developed a novel pentablock polymeric poly(ethylene glycol)-b-(poly(2-(diethylamino) ethyl methacrylate)-b-poly (hydroxyethyl methacrylate)-g-folic acid)2 [PEG-b-(PDEAEMA-b-PHEMA-g-FA)2] micelles as anticancer drug nanocarrier. The carriers could target tumor cells rapidly, and response to the tumor sites pH to control drug release...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024701/dha-and-pgpma-dual-modified-ph-sensitive-polymeric-micelles-for-target-treatment-of-liver-cancer
#13
Haojun Ma
In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to the failure of chemotherapeutical agents to accumulate in tumor as well as lack of potency of tumor penetration. In this work, we developed actively tumor-targeting micelles with pH-sensitive linker as a novel nanocarrier for HCC therapy. These micelles comprised of biodegradable PEG-pAsp polymers, in which PTX can be covalently conjugated to pAsp via an acid-labile acetal bond to form pH-responsive structures...
October 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29024217/use-of-the-target-of-rapamycin-fatc-domain-as-a-general-membrane-anchor-the-fkbp-12-like-domain-of-fkbp38-as-a-case-study
#14
Maristella De Cicco, Lech-G Milroy, Sonja A Dames
Increased efforts have been undertaken to better understand the formation of signaling complexes at cellular membranes. Since the preparation of proteins containing a transmembrane domain or a prenylation motif is generally challenging an alternative membrane anchoring unit that is easy to attach, water-soluble and binds to different membrane mimetics would find broad application. The 33-residue long FATC domain of yeast TOR1 (y1fatc) fulfills these criteria and binds to neutral and negatively charged micelles, bicelles and liposomes...
October 12, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29022980/the-effect-of-compressed-co2-on-the-self-assembly-of-surfactants-for-facile-preparation-of-ordered-mesoporous-carbon-materials
#15
Xin Huang, Wei Li, Shuang Li, Cheng Wang, Mengnan Zhang, Sen Luan, Xiaojian Hou, Qian Wang
The effect of compressed CO2 on the properties of ordered mesoporous carbon (OMC) was investigated based on the self-assembly of surfactants in aqueous solution under mild conditions, and the acidic or basic conditions commonly used in traditional methods were substituted by compressed CO2. Compressed CO2 acts as both a physiochemical additive and a reagent to produce an acid catalyst in the synthesis. This new one-pot assembly approach can efficiently adjust the porous characteristics of OMC by employing different amounts of compressed CO2, and the self-assembly mechanism is proposed...
October 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/29022966/thermo-responsive-self-immolative-nanoassemblies-direct-and-indirect-triggering
#16
Bo Fan, John F Trant, Gauvin Hemery, Olivier Sandre, Elizabeth R Gillies
A thermo-responsive end-cap based on a retro-Diels-Alder and subsequent furan elimination reaction was developed. It was used to cap poly(ethyl glyoxylate), allowing end-to-end depolymerization upon thermal triggering. Using block copolymers, thermo-responsive micelles and vesicles were prepared and shown to disassemble upon heating. Thermal degradation could also be triggered indirectly by magnetic field hyperthermia after incorporation of iron oxide nanoparticles into the assemblies.
October 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29021495/structure-of-the-microemulsion-of-polyglycerol-polyricinoleate-encapsulating-vitamin-e
#17
Junji Matsuoka, Takumi Kusano, Yuuki Kasama, Etsuko Tominaga, Junya Kobayashi, Wataru Fujii, Hiroki Iwase, Mitsuhiro Shibayama, Hironobu Nanbu
The structures of micelles and microemulsions consisting of polyglycerol polyricinoleate (PGPR) were investigated by small-angle X-ray scattering (SAXS) and rheological measurements. The SAXS results show that amphiphilic PGPR molecules form stable micelles in glycerol. When vitamin E is added to the PGPR micelles, it is encapsulated in the micelles and forms an emulsion. These micelles are stable towards mechanical shearing up to a shear rate of 1000 s(-1), with shear thinning occurring in the emulsion above 100 s(-1), indicating that the emulsion may undergo break up by shearing, but recovers the structure by releasing shear strain...
October 11, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29019482/novel-poly-vinyl-alcohol-based-amphiphilic-nanogels-by-non-covalent-boric-acid-crosslinking-of-polymeric-micelles
#18
Hen Moshe, Yuval Davizon, Maya Menaker Raskin, Alejandro Sosnik
In this work, we report a new type of poly(vinyl alcohol)-g-poly(N-isopropylacrylamide) (PVA-g-PNiPAAm) amphiphilic nanogel produced by the non-covalent crosslinking of PVA polyol domains in preformed polymeric micelles with boric acid. The nanomaterials showed sizes in the 100-250 nm range (DLS) and a spherical morphology (HR-SEM). We demonstrated that the size of the polymeric micelles could be fine-tuned by changing the concentration (and the aggregation pattern) of the polymeric amphiphile in water. Upon crosslinking, the polymeric micelles turned into physically stable amphiphilic nanogels that displayed both size and size distribution similar to the micellar precursor for up to two weeks, even under disfavored conditions of concentration and temperature that, in the case of non-crosslinked counterparts, resulted in quick disassembly...
October 11, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29019240/ph-dependent-assembly-of-porphyrin-silica-nanocomposites-and-their-application-in-targeted-photodynamic-therapy
#19
Jiefei Wang, Yong Zhong, Xiao Wang, Weitao Yang, Feng Bai, Bingbo Zhang, Leanne Alarid, Kaifu Bian, Hongyou Fan
Structurally controlled nanoparticles, such as core-shell nanocomposite particles by combining two or more compositions possess enhanced or new functionalities that benefited from synergistic coupling of the two components. Here we report new nanocomposite particles with self-assembled porphyrin arrays as the core surrounded by amorphous silica as the shell. Synthesis of such nanocomposite nanoparticles was conducted through a combined surfactant micelle confined self-assembly and silicate sol-gel process using optically active porphyrin as a functional building block...
October 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/29019073/cholecalciferol-peg-conjugate%C3%A2-based-nanomicelles-of-doxorubicin-for-treatment-of-triple-negative-breast-cancer
#20
Shallu Kutlehria, Gautam Behl, Ketan Patel, Ravi Doddapaneni, Imran Vhora, Nusrat Chowdhury, Arvind Bagde, Mandip Singh
Triple-negative breast cancer (TNBC) is the leading cancer in women. Chemotherapeutic agents used for TNBC are mainly associated with dose-dependent toxicities and development of resistance. Hence, novel strategies to overcome resistance and to offer dose reduction are warranted. In this study, we designed a novel dual-functioning agent, conjugate of cholecalciferol with PEG2000 (PEGCCF) which can self-assemble into micelles to encapsulate doxorubicin (DOX) and act as a chemosensitizer to improve the therapeutic potential of DOX...
October 10, 2017: AAPS PharmSciTech
keyword
keyword
56695
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"