keyword
MENU ▼
Read by QxMD icon Read
search

Micelle

keyword
https://www.readbyqxmd.com/read/28231499/surfactant-cobalt-iii-complexes-the-impact-of-hydrophobicity-on-interaction-with-hsa-and-dna-insights-from-experimental-and-theoretical-approach
#1
Selvakumar Veeralakshmi, Gopal Sabapathi, Selvan Nehru, Ponnambalam Venuvanalingam, Sankaralingam Arunachalam
To develop surfactant-based metallodrugs, it is very important to know about their hydrophobicity, micelle forming capacity, their interaction with biomacromolecules such as proteins and nucleic acids, and biological activities. Here, diethylenetriamine (dien) and tetradecylamine ligand (TA) based surfactant-cobalt(III) complexes with single chain domain, [Co(dien)(TA)Cl2]ClO4 (1) and double chain domain [Co(dien)(TA)2Cl](ClO4)2 (2) were chosen to study the effect of hydrophobicity on the interaction with human serum albumin and calf thymus DNA...
February 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28230046/gel-phase-formation-in-dilute-triblock-copolyelectrolyte-complexes
#2
Samanvaya Srivastava, Marat Andreev, Adam E Levi, David J Goldfeld, Jun Mao, William T Heller, Vivek M Prabhu, Juan J de Pablo, Matthew V Tirrell
Assembly of oppositely charged triblock copolyelectrolytes into phase-separated gels at low polymer concentrations (<1% by mass) has been observed in scattering experiments and molecular dynamics simulations. Here we show that in contrast to uncharged, amphiphilic block copolymers that form discrete micelles at low concentrations and enter a phase of strongly interacting micelles in a gradual manner with increasing concentration, the formation of a dilute phase of individual micelles is prevented in polyelectrolyte complexation-driven assembly of triblock copolyelectrolytes...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28228078/nanocarriers-mediated-topical-drug-delivery-for-psoriasis-treatment
#3
Sevgi Güngör, Meriem Rezigue
BACKGROUND: Psoriasis is a chronic autoimmune inflammatory skin disease affecting 2 to 3% of people worldwide. Topical therapy as first option in the management of psoriasis is an attractive strategy by delivering drugs efficiently into target sites of disease, minimizing systemic side effects of drugs and ensuring high patient compliance. However, the delivery of antipsoriatic agents via conventional topical formulations is limited due to their poor percutaneous penetration and targeting into deeper layers of the skin...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28225285/multi-scale-modeling-of-the-effects-of-salt-and-perfume-raw-materials-on-the-rheological-properties-of-commercial-thread-like-micellar-solutions
#4
Xueming Tang, Weizhong Zou, Peter H Koenig, Shawn D McConaughy, Michael R Weaver, David Michael Eike, Michael J Schmidt, Ronald G Larson
We link micellar structures to rheological properties for two surfactant body-wash formulations at various concentrations of salts and perfume raw materials (PRMs) using molecular simulations and micellar-scale modeling as well as traditional surfactant packing arguments. The two body washes, named BW-1EO and BW-3EO, are composed of sodium lauryl ethylene glycol ether sulfate (SLEnS, where n is the average number of ethylene glycol repeat units), cocamidopropyl betaine (CAPB), ACCORD (which is a mixture of six PRMs), and NaCl salt...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28225102/stability-of-reverse-micelles-in-rare-earth-separation-a-chemical-model-based-on-a-molecular-approach
#5
Yushu Chen, Magali Duvail, Philippe Guilbaud, Jean-François Dufrêche
Molecular complexes formed in the organic phase during solvent extraction may self-assemble as reverse micelles, and therefore induce a supramolecular organization of this phase. In most of the cases, water molecules play an essential role in the organization of this non polar medium. The aim of this work is to investigate the speciation of the aggregates formed in the organic phase during solvent extraction, and especially to assess their stability as a function of the number of water molecules included in their polar core...
February 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28225045/membrane-targeting-of-tirap-is-negatively-regulated-by-phosphorylation-in-its-phosphoinositide-binding-motif
#6
Xiaolin Zhao, Wen Xiong, Shuyan Xiao, Tuo-Xian Tang, Jeffrey F Ellena, Geoffrey S Armstrong, Carla V Finkielstein, Daniel G S Capelluto
Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimerize and move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains. At these sites, TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling cascade that leads to innate immune responses. Membrane recruitment of TIRAP is mediated by its phosphoinositide (PI)-binding motif (PBM). We show that TIRAP PBM transitions from a disordered to a helical conformation in the presence of either zwitterionic micelles or monodispersed PIs...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224892/construction-and-in-vitro-evaluation-of-enzyme-nanoreactors-based-on-carboxymethyl-chitosan-for-arginine-deprivation-in-cancer-therapy
#7
Tian Zeng, Yi Zhang, Qiongjiao Yan, Zhijun Huang, Ling Zhang, Xiaozhe Yi, Junrong Chen, Guanghua He, Yihua Yin
In this study, a pH-induced morphological transition from micelles to vesicles for an amphiphilic photo cross-linkable biocopolymer (Az-NaCMCS), synthesized by mixing azidobenzaldehyde (Az) and an aqueous solution of carboxymethyl chitosan sodium salt (NaCMCS), was used for encapsulation of l-arginine deiminase (ADI). The aqueous solution of enzyme-loaded vesicles obtained was followed by UV-irradiation to result in shell cross-linked enzyme nanoreactors. The nanoreactors were characterized by TEM and DLS. Its encapsulation efficiency and loading capacity were determined...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28224157/smart-worm-like-micelles-responsive-to-co2-n2-and-light-dual-stimuli
#8
Jianzhong Jiang, Guozheng Wang, Yuxuan Ma, Zhenggang Cui, Bernard P Binks
CO2/N2 and light dual stimuli-responsive worm-like micelles (WLMs) were obtained by addition of a relatively small amount of a switchable surfactant, 4-butyl-4'-(4-N,N-dimethylhexyloxy-amine) azobenzene bicarbonate (AZO-B6-CO2), sensitive to the same triggers to a binary aqueous solution of cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal).
February 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28223798/transferrin-receptor-targeted-ph-sensitive-micellar-system-for-diminution-of-drug-resistance-and-targetable-delivery-in-multidrug-resistant-breast-cancer
#9
Wei Gao, Guihua Ye, Xiaochuan Duan, Xiaoying Yang, Victor C Yang
The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG2000) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG2000) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG2000 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG2000) or 7pep-DSPE-PEG2000 (7-pep HD micelles)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28222395/technetium-99m-radiolabeled-paclitaxel-as-an-imaging-probe-for-breast-cancer-in-vivo
#10
Liziane O F Monteiro, Renata S Fernandes, Luciano C Castro, Valbert N Cardoso, Mônica C Oliveira, Danyelle M Townsend, Alice Ferretti, Domenico Rubello, Elaine A Leite, André L B de Barros
The high incidence and mortality of breast cancer supports efforts to develop innovative imaging probes to effectively diagnose, evaluate the extent of the tumor, and predict the efficacy of tumor treatments while concurrently and selectively delivering anticancer agents to the cancer tissue. In the present study we described the preparation of technetium-99m ((99m)Tc)-labeled paclitaxel (PTX) and evaluated its feasibility as a radiotracer for breast tumors (4T1) in BALB/c mice. Thin Layer Chromatography (TLC) was used to determine the radiochemical purity and in vitro stability of (99m)Tc-PTX...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28221812/intermicellar-interactions-and-the-viscoelasticity-of-surfactant-solutions-complementary-use-of-sans-and-saxs
#11
Viviane Lutz-Bueno, Marianne Liebi, Joachim Kohlbrecher, Peter Fischer
In ionic surfactant micelles, basic interactions among distinct parts of surfactant monomers, their counterion, and additives are fundamental to tune molecular self-assembly and enhance viscoelasticity. Here, we investigate the addition of sodium salicylate (NaSal) to hexa-decyltrimethyl ammonium chloride and bromide (CTAC and CTAB) and 1-hexa-decyl pyridinium chloride and bromide (CPyCl and CPyBr), which have distinct counterions and headgroup structures, but the same hydrophobic tail. Different contrasts are obtained from small-angle neutron scattering SANS, which probes differences between the nucleus of atoms, and X-rays SAXS, which probes differences in electron density...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221801/balancing-segregation-and-complexation-in-amphiphilic-copolymers-by-architecture-and-confinement
#12
Pascal Hebbeker, Alexander A Steinschulte, Stefanie Schneider, Felix A Plamper
Segregation is a well-known principle for micellization, as solvophobic components try to minimize interactions with other entities (such as solvent) by self-assembly. An opposite principle is based on complexation (or coacervation), leading to the coassembly/association of different components. Most cases in the literature rely on only one of these modes, though the classical micellization scheme (such as spherical micelles, wormlike micelles, and vesicles) can be enriched by a subtle balance of segregation and complexation...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221800/self-associating-poly-ethylene-oxide-block-poly-%C3%AE%C2%B5-caprolactone-peo-b-pcl-drug-conjugates-for-the-delivery-of-stat3-inhibitor-jsi-124-potential-application-in-cancer-immunotherapy
#13
Shyam M Garg, Mohammad Reza Vakili, Ommoleila Molavi, Afsaneh Lavasanifar
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) in tumor cells and tumor associated dendritic cells (DCs) plays a major role in the progression of cancer. JSI-124 (Cucurbitacin I) is a potent inhibitor of STAT3, however, its poor solubility and non-specificity limits its effectiveness in cancer immunotherapy. In order to achieve a nano-carrier for solubilisation and passive targeting of JSI-124 to tumor cells and tumor associated DCs, the drug was chemically conjugated to pendent COOH groups of self-associating poly(ethylene oxide)-block-poly(-carboxylate-ε-caprolactone) (PEO-b-PCCL)...
February 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28221732/facile-fabrication-of-aie-active-fluorescent-polymeric-nanoparticles-with-ultra-low-critical-micelle-concentration-based-on-ce-iv-redox-polymerization-for-biological-imaging-applications
#14
Qing Wan, Dazhuang Xu, Liucheng Mao, Ziyang He, Guangjian Zeng, Yingge Shi, Fengjie Deng, Meiying Liu, Xiaoyong Zhang, Yen Wei
Fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) property have received increasing attention and possess promising biomedical application potential in the recent years. Many efforts have been devoted to the fabrication methodologies of FPNs and significant advance has been achieved. In this contribution, a novel strategy for the fabrication of AIE-active amphiphilic copolymers is reported for the first time based on the Ce(IV) redox polymerization. As an example, ene group containing AIE-active dye (named as Phe-alc) is directly grafted onto a water soluble polymer polyethylene glycol (PEG) in H2 O/THF system under low temperature...
February 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28221045/hierarchical-colloidal-polymeric-structure-from-surfactant-like-amphiphiles-in-selective-solvents
#15
Chenglin Wang, Shiying Ma, Yi Hu, Rong Wang
We investigated the self-assembly of surfactant-like amphiphile consisting of a hydrophilic head and a hydrophobic tail using dissipative particle dynamics method. By controlling the interaction parameter between the hydrophilic head and the solvent, the length of hydrophobic tail, the size of hydrophilic head, and the polymer concentration, we found seven self-assembled morphologies, including sphere-like micelle, pomegranate-like micelle, hierarchical colloidal polymeric structure, pomegranate-like columnar structure, branched hybrid structure, disk-like micelle, and vesicle...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28220208/abcb4-missense-mutations-d243a-k435t-g535d-i490t-r545c-and-s978p-significantly-impair-the-lipid-floppase-and-likely-predispose-to-secondary-pathologies-in-the-human-population
#16
Edward J Andress, Michael Nicolaou, Farrell McGeoghan, Kenneth J Linton
Bile salts are natural detergents required to solubilise dietary fat and lipid soluble vitamins. They are synthesised in hepatocytes and secreted into the luminal space of the biliary tree by the bile salt export pump (BSEP), an ATP-binding cassette (ABC) transporter in the canalicular membrane. BSEP deficiency causes cytotoxic accumulation of bile salts in the hepatocyte that results in mild-to-severe forms of cholestasis. The resulting inflammation can also progress to hepatocellular cancer via a novel mechanism involving upregulation of proliferative signalling pathways...
February 20, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28219244/an-alternative-route-to-nanoscale-aggregates-with-a-ph-responsive-random-copolymer
#17
Jonathan C Pegg, Adam Czajka, Christopher Hill, Craig James, Jocelyn Alice Peach, Sarah E Rogers, Julian Eastoe
A random copolymer, poly(methyl methacrylate-co-2-dimethylaminoethyl methacrylate) (poly(MMA-co-DMAEMA)) is shown to form nano-scale aggregates (NAs) (~20 nm) at copolymer concentrations ≥ 10 % w/w, directly from the pre-formed surfactant-stabilised latex (~120 nm) in aqueous solution. The copolymer is prepared by a conventional emulsion polymerisation. Introducing a small mole fraction of DMAEMA (~10 %) allows the copolymer hydrophilicity to be adjusted by pH and external temperature, generating NAs with tuneable sizes and defined weight-average aggregation number, as observed by dynamic-light scattering (DLS) and small-angle neutron scattering (SANS)...
February 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28216010/uptake-of-benzo-a-pyrene-but-not-of-phenanthrene-is-inhibited-by-fatty-acids-in-intestinal-brush-border-membrane-vesicles-of-rainbow-trout-oncorhynchus-mykiss
#18
Stefan de Gelder, Liselot van Och, Jan Zethof, Thamar N M Pelgrim, Josef D Rasinger, Gert Flik, Marc H G Berntssen, Peter H M Klaren
Partial replacement of fish ingredients with vegetable ingredients has elevated levels of polycyclic aromatic hydrocarbons (PAHs) in Atlantic salmon reared on these feeds. PAH uptake in the intestinal tract is postulated to occur in association with lipid absorption and could well be affected by fatty acid composition. We therefore investigated the effects of a fish oil and vegetable oil fatty acid, eicosapentaenoic acid (EPA; 20:5n-3) and oleic acid (18:1n-9) respectively, on the uptake of benzo[a]pyrene (BaP) and phenanthrene (PHE) across the intestinal brush border membrane in the salmonid species rainbow trout (Oncorhynchus mykiss)...
February 12, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28215509/triphenylphosphonium-modified-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-micelles-for-mitochondria-targeted-gambogic-acid-delivery
#19
Yingqi Xu, Shengpeng Wang, Hon Fai Chan, Yuling Liu, Hui Li, Chengwei He, Zeyong Li, Meiwan Chen
Mitochondria are important targets for the intracellular delivery of drugs and DNA. For mitochondria-targeted delivery, a mitochondriotropic molecule, triphenylphosphonium (TPP), was applied to the synthesis of amphiphilic TPP-poly(ethylene glycol)-poly(ε-caprolactone) (TPP-PEG-PCL) polymers. The TPP-PEG-PCL polymer was used to prepare micelles using a solvent evaporation method for the delivery of gambogic acid (GA) (GA-TPP). The micelles were obtained with a favorable particle size of 150.07±11.71nm and an encapsulation efficiency of 80...
February 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28215155/magnetic-nanoparticles-new-perspectives-in-drug-delivery
#20
Joanna Wong, Jeremy Prout, Alexander Seifalian
BACKGROUND: The study of magnetic nanoparticles (MNPs) for drug delivery has recently seen a surge of interest even though the first studies were conducted as early as in the seventies. Despite this, there are still gaps in the knowledge of the field, implicating the complexities in designing the ideal MNP for drug delivery. The large surface area of MNPs and the ability to manipulate with an externally applied magnetic field render the MNP a good candidate for targeted delivery of drugs...
February 14, 2017: Current Pharmaceutical Design
keyword
keyword
56695
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"