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https://www.readbyqxmd.com/read/29677613/swollen-mixed-pluronic-surfactant-micelles-as-templates-for-mesoporous-nanotubes-with-diverse-bridged-organosilica-frameworks
#1
Manik Mandal, George Farid, Michal Kruk
Bridged-organosilica nanotubes with a variety of bridging groups (methylene, ethylene, ethenylene, phenylene and p-xylylene) were synthesized using swollen mixtures of Pluronic triblock copolymer surfactants as micellar templates. The mixtures consisted of Pluronic F127 surfactant (EO106 PO70 EO106 ) with long poly(ethylene oxide), PEO, blocks, which help prevent the formation of consolidated structures, and another Pluronic with shorter PEO blocks and higher poly(propylene oxide) content, which promote swelling and the cylindrical micelle morphology...
April 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29677448/self-assembled-ph-responsive-polymeric-micelles-for-highly-efficient-non-cytotoxic-delivery-of-doxorubicin-chemotherapy-to-inhibit-macrophage-activation-in-vitro-investigation
#2
Zhi-Sheng Liao, Shan-You Huang, Jyun-Jie Huang, Jem-Kun Chen, Ai-Wei Lee, Juin-Yih Lai, Duu-Jong Lee, Chih-Chia Cheng
Self-assembled pH-responsive polymeric micelles, a combination of hydrophilic poly(ethylene glycol) segments and hydrogen bonding interactions within a biocompatible polyurethane substrate, can spontaneously self-assemble into highly controlled, nanosized micelles in aqueous solution. These newly-developed micelles exhibit excellent pH-responsive behavior and biocompatibility, highly controlled drug (doxorubicin; DOX) release behavior and high drug encapsulation stability in different aqueous environments, making the micelles highly attractive potential candidates for safer, more effective drug delivery in applications such as cancer chemotherapy...
April 20, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29675667/mpeg-pcl-copolymeric-micelles-for-encapsulation-of-azithromycin
#3
Wenxiu Wei, Shida Li, Hongmei Xu, Feilong Zhou, Yi Wen, Zhimei Song, Sijia Feng, Runliang Feng
Macrolide antibiotics are lipophilic drugs with some limitations including low solubility, limited cellular permeation, patients discomfort, etc. With amphiphilic methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (MPEG-PCL) copolymer and azithromycin (AZT) as drug carrier and model drug, AZT-loaded micelles were prepared via thin-membrane hydration method in order to overcome these limitations. Encapsulation efficiency of AZT-loaded micelles was 94.40% with good storage stability for 28 days, and AZT's water solubility was enhanced to 944 μg/mL...
April 19, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29675229/lipid-bilayer-environments-control-exchange-kinetics-of-deep-cavitand-hosts-and-enhance-disfavored-guest-conformations
#4
Lizeth Perez, Bethany G Caulkins, Magi Mettry, Leonard J Mueller, Richard J Hooley
The effects on the molecular recognition properties of water-soluble deep cavitand hosts upon embedding them in phosphocholine lipid bilayer environments have been studied by 2D NMR experiments. By employing suitable guests containing 19 F or 13 C nuclei that can be encapsulated inside the host, 2D EXSY NMR experiments can be used to analyze and compare the in/out guest exchange rates in aqueous solution, isotropically tumbling micelles, or magnetically ordered bicelles. These analyses show that embedding the deep cavitands in lipid bilayers slows the guest exchange rate, due to the lipids acting as a "compression sleeve" around the host, restricting guest egress...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675210/dynamical-inversion-of-the-energy-landscape-promotes-non-equilibrium-self-assembly-of-binary-mixtures
#5
Luis Ruiz Pestana, Natalie Minnetian, Laura Nielsen Lammers, Teresa Head-Gordon
When driven out of equilibrium, many diverse systems can form complex spatial and dynamical patterns, even in the absence of attractive interactions. Using kinetic Monte Carlo simulations, we investigate the phase behavior of a binary system of particles of dissimilar size confined between semiflexible planar surfaces, in which the nanoconfinement introduces a non-local coupling between particles, which we model as an activation energy barrier to diffusion that decreases with the local fraction of the larger particle...
February 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674293/protein-adsorption-and-macrophage-uptake-of-zwitterionic-sulfobetaine-containing-micelles
#6
Aijing Lu, Zhengzhong Wu, Xianglin Luo, Suming Li
Micelles of poly(ε-caprolactone)-b-poly(N,N-diethylaminoethyl methacrylate)/(N-(3-sulfopropyl-N-methacryloxyethy-N,N-diethylammonium betaine)) (PCL-PDEAPS) and poly(ε-caprolactone)-b-poly(ethylene glycol) (PCL-PEG) were prepared and characterized. The interactions of micelles with model proteins such as bovine serum albumin (BSA), lysozyme (Ly), fibrinogen (Fg) and plasma were studied from adsorption quantity, micelle size, polydispersity index (PDI) and zeta-potential measurements. The adsorption quantity of negatively charged proteins on PCL-PDEAPS micelles containing zwitterionic sulfobetaine is larger than on non-ionic PEG-PCL micelles...
April 9, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29673646/polymeric-micelles-encapsulating-ph-responsive-doxorubicin-prodrug-and-glutathione-activated-zinc-ii-phthalocyanine-for-combined-chemotherapy-and-photodynamic-therapy
#7
Di Gao, Pui-Chi Lo
A series of polymeric micelles encapsulating different ratios of doxorubicin (DOX) and zinc(II) phthalocyanine (ZnPc) have been prepared for dual chemotherapy and photodynamic therapy (PDT). The amphiphilic block copolymers consist of methoxypolyethylene glycol (PEG) and poly(β-benzyl-l-aspartate) (PBLA), in which DOX and ZnPc were conjugated to the aspartate side chain through an acid-labile hydrazone linker and a redox-responsive disulfide linker, respectively. The polymers were self-assembled into spherical polymeric micelles with diameters of about 160-180 nm and their surface charges were found to be nearly neutral due to the outermost PEG layer...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29672958/various-phase-behaviors-and-rich-aggregates-in-a-catanionic-system-dominated-by-an-anionic-surfactant-containing-a-large-rigid-group
#8
Zhai Zhaolan, Yan Xinyan, Ji Xu, Song Zhanqian, Shang Shibin, Xiaoping Rao
The phase behaviors and aggregates in a catanionic system have been investigated. The anionic surfactants in the mixed systems are sodium N-alkyl-maleimidepimaric carboxylate (Cn-MPA-Na, n=12, 14, 16), which are prepared from rosin and contain a large rigid skeleton and a flexible alkane chain. And the cationic surfactant is cetyltrimethylammonium bromide (CTAB). The phase behavior of C14-MPA-Na/CTAB system transforms form a viscoelastic solution to an aqueous surfactant two-phase system (ASTP), an aqueous surfactant three-phase system (AS3P) and an anisotropic homogeneous phase in sequence when C14-MPA-Na concentration continuously increases from 10 to 35 mM...
April 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29671847/intensely-phosphorescent-block-copolymer-micelles-containing-gold-i-complexes
#9
Pingxia Guo, Qun He, Chen Wang, Zaili Hou, Bingran Yu, Weifeng Bu
The electrostatic combination of anionic block copolymers with cationic gold(i) complexes leads to the formation of spherical micelles, where gold(i)-containing ionic cores were formed with anionic blocks and further stabilized by neutral blocks of polystyrene or poly(ethylene oxide). This self-assembled strategy induces remarkable phosphorescence enhancement of the gold(i) complexes in solution. The emissive intensity increases unexpectedly with increasing molecular weight of the anionic block that is not coordinated onto the gold(i) complexes...
April 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29669207/ros-inducing-micelles-sensitize-tumor-associated-macrophages-to-tlr3-stimulation-for-potent-immunotherapy
#10
Lanlan Liu, Huamei He, Ruijing Liang, Huqiang Yi, Xiaoqing Meng, Zhikuan Chen, Hong Pan, Yifan Ma, Lintao Cai
One approach to cancer immunotherapy is the repolarization of immunosuppressive tumor-associated macrophages (TAMs) to anti-tumor M1 macrophages. The present study developed galactose-functionalized zinc protoporphyrin IX (ZnPP) grafted poly(L-lysine)-b-poly(ethyleneglycol) polypeptide micelles (ZnPP PM ) for TAM-targeted immunopotentiator delivery, which aimed at in vivo repolarization of TAMs to anti-tumor M1 macrophages. The outcomes revealed that ROS-inducing ZnPP PM demonstrated specificity for the in vitro and in vivo targeting of macrophages, elevated the level of ROS, and lowered STAT3 expression in BM-TAMs...
April 18, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29668278/combining-freezing-point-depression-and-self-diffusion-data-for-characterizing-aggregation
#11
Markus M Hoffmann, Sarah Bothe, Torsten Gutmann, Gerd Buntkowsky
The colligative property freezing point depression is evaluated as a means for estimating the extent of aggregation for solutions of poly(ethylene oxide) alcohol (C10E6) nonionic surfactant in cyclohexane. Combined with additional measurements of self-diffusion coefficients, it is shown that both un-aggregated C10E6 as well as reverse micelles are significantly present for the entire range of measured C10E6 concentration (0.048 mol·kg-1 - 2.35 mol·kg-1). A change in speciation near 0.2 mol·kg-1 is indicated by both the results from freezing point depression and self-diffusion coefficients measurements...
April 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29667444/akt2-sirna-delivery-with-amphiphilic-based-polymeric-micelles-show-efficacy-against-cancer-stem-cells
#12
Diana Rafael, Petra Gener, Fernanda Andrade, Joaquin Seras-Franzoso, Sara Montero, Yolanda Fernández, Manuel Hidalgo, Diego Arango, Joan Sayós, Helena F Florindo, Ibane Abasolo, Simó Schwartz, Mafalda Videira
Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the progressive gain of resistance of advanced cancers, new anticancer therapies should be validated specifically for this subpopulation of cells. A new amphihilic-based gene delivery system that combines Pluronic® F127 micelles with polyplexes spontaneously formed by electrostatic interaction between anionic siRNA and cationic polyethylenimine (PEI) 10K, was designed (PM)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29667316/opposite-effects-of-the-spinach-food-matrix-on-lutein-bioaccessibility-and-intestinal-uptake-lead-to-unchanged-bioavailability-compared-to-pure-lutein
#13
Marielle Margier, Caroline Buffière, Pascale Goupy, Didier Remond, Charlotte Halimi, Catherine Caris, Patrick Borel, Emmanuelle Reboul
SCOPE: Food matrix is generally believed to alter carotenoid bioavailability, but its effect on xanthophylls is usually limited. We thus aimed to decipher the digestion-absorption process of lutein in the presence or not of a food matrix. METHODS: We assessed lutein transfer to gastric-like lipid droplets or artificial mixed micelles when lutein was added to test meals either as a pure molecule ((all-E)-lutein) or in canned spinach ((Z) + (all-E)-lutein). The obtained mixed micelles were delivered to Caco-2 cells to evaluate lutein uptake...
April 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29666865/preparation-of-lactic-acid-and-glucose-responsive-poly-%C3%AE%C2%B5-caprolactone-b-poly-ethylene-oxide-block-copolymer-micelles-using-phenylboronic-ester-as-a-sensitive-block-linkage
#14
David Vrbata, Mariusz Uchman
The present study describes the synthesis, self-assembly and responsiveness to glucose and lactic acid of biocompatible and biodegradable block copolymer micelles using phenylboronic ester as the linkage between hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene oxide) (PEO). The PCL block with pendant phenylboronic acid (PCLBA) was synthesized by combining ε-caprolactone (ε-CL) ring-opening polymerisation (ROP), using 4-hydroxymethyl(phenylboronic) acid pinacolate as the initiator, and pinacol deprotection...
April 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29664641/simulations-study-of-single-component-and-mixed-n-alkyl-peg-micelles
#15
Maisa Vuorte, Jukka Määttä, Maria Sammalkorpi
Here, we study one component and mixed n-alkyl-poly(ethylene oxide) (Cm En ) micelles with varying poly(ethylene oxide) (PEG) chain lengths n using coarse-grained molecular simulations. These non-ionic alkyl-PEG surfactants and their aggregates are widely used in bio and chemical technology. As expected, the simulations show that increasing the PEG chain length decreases the alkyl-PEG micelle core diameter and aggregation number but also enhances PEG chain penetration to the core region and spreads the micelle corona...
April 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29664078/photodegradation-of-2-4-4-tribrominated-diphenyl-ether-in-various-surfactant-solutions-kinetics-mechanisms-and-intermediates
#16
Kaibo Huang, Guining Lu, Zhiqiang Zheng, Rui Wang, Ting Tang, Xueqin Tao, Ruibing Cai, Zhi Dang, Pingxiao Wu, Hua Yin
Currently, photodegradation has been proven to be an important way of eliminating polybrominated diphenyl ethers (PBDEs) from the environment. However, the mechanism of PBDE photodegradation in surfactants by UV light is still unclear. In this study, 2,4,4'-tribrominated diphenyl ether (BDE-28) was selected as the target pollutant to investigate the photodegradation of PBDEs in Triton X-100 (TX-100), sodium dodecylbenzenesulfonate (SDBS) and cetyltrimethylammonium bromide (CTAB) solutions. All photolysis experiments were performed above the critical micelle concentration (CMC)...
April 17, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29663921/multifunctional-hyaluronic-acid-decorated-redox-responsive-magnetic-complex-micelle-for-targeted-drug-delivery-with-enhanced-antitumor-efficiency-and-anti-cell-migration-activity
#17
Mangmang Sang, Zhongtao Zhang, Fulei Liu, Lejian Hu, Lingchao Li, Li Chen, Feng Feng, Wenyuan Liu, Wei Qu
A novel multifunctional hyaluronic acid-decorated redox-responsive magnetic complex micelle (HA/CSO-SS-Hex/Fe3O4/PTX) based on a reducible hexadecanol-modified chitosan oligosaccharide polymer micelle (CSO-SS-Hex) coated with hyaluronic acid (HA) and loaded with paclitaxel (PTX) Fe3O4 nanoparticles is developed. HA is coated onto the surface of micelles via electrostatic absorption and acts as a targeting ligand for CD44 over expression in many tumor cells. A CSO-SS-Hex polymer micelle was used for PTX incorporation and GSH-triggered intracellular release...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663556/structure-and-dynamics-of-the-extended-helix-state-of-alpha-synuclein-intrinsic-lability-of-the-linker-region
#18
Yoon-Hui Sung, David Eliezer
The Parkinson's protein alpha-synuclein binds to synaptic vesicles in vivo and adopts a highly extended helical conformation when binding to lipid vesicles in vitro. High-resolution structural analysis of alpha-synuclein bound to small lipid or detergent micelles revealed two helices connected by a non-helical linker, but corresponding studies of the vesicle-bound extended-helix state are hampered by the size and heterogeneity of the protein-vesicle complex. Here we employ fluorinated alcohols (FAs) to induce a highly helical aggregation-resistant state of alpha-synuclein in solution that resembles the vesicle-bound extended-helix state but is amenable to characterization using high-resolution solution-state NMR...
April 16, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29663150/preparation-of-a-novel-lipid-core-micelle-using-a-low-energy-emulsification-method
#19
Hans F Fritz, Andrea C Ortiz, Sitaram P Velaga, Javier O Morales
High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsulate a poorly water-soluble drug, nifedipine (NFD), by hot-melt emulsification, a low-energy method. LCMs are self-assembling colloidal particles composed of a hydrophobic core and a hydrophilic shell...
April 16, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29663141/tacrolimus-loaded-peg-cholecalciferol-based-micelles-for-treatment-of-ocular-inflammation
#20
Shallu Kutlehria, Imran Vhora, Arvind Bagde, Nusrat Chowdhury, Gautam Behl, Ketan Patel, Mandip Singh
PURPOSE: Poor corneal permeability, nasolacrimal drainage and requirement of chronic administration are major drawbacks of existing therapies for ocular inflammation. Hence, we designed topical micelles of PEG2000 conjugated with cholecalciferol (PEGCCF). METHODS: Integrin targeted tacrolimus loaded PEGCCF micelles (TTM) were prepared by solvent diffusion evaporation method and characterized for particle size, osmolality, encapsulation efficiency and drug loading...
April 16, 2018: Pharmaceutical Research
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