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Cancer AND herbs

Guanghui Lian, Fujun Li, Yani Yin, Linlin Chen, Junwen Yang
PURPOSE: Artemisia vulgaris (A.vulgaris) belonging to family Compositae, commonly known as mugwort, has been used as a medicinal herb in Chinese traditional medicine for treatment of diseases. Studies have reported a diversity of activities for this plant which include antiseptic, antispasmodic, antigastric, anticancer and nervous system diseases. However, the anticancer activity of A.vulgaris in HCT-15 human colon cancer cells has not been scientifically validated. Therefore the present study aimed at evaluating the anticancer activity of methanolic extract of A...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jingxiao Wang, Xinjie Yang, Haibo Han, Limin Wang, Weiqian Bao, Shanshan Wang, Robert M Hoffman, Meng Yang, Hui Qi, Chao An, Kaiwen Hu
Objective: Triple-negative breast cancer (TNBC) is highly invasive and metastatic, which is in urgent need of transformative therapeutics. Tubeimu (TBM), the rhizome of Bolbostemma paniculatum (Maxim.) Franquet, is one of the Chinese medicinal herbs used for breast diseases since the ancient times. The present study evaluated the efficacy, especially the anti-metastatic effects of the dichloromethane extract of Tubeimu (ETBM) on TNBC orthotopic mouse models and cell lines. Methods: We applied real-time imaging on florescent orthotopic TNBC mice model and tested cell migration and invasion abilities with MDA-MB-231 cell line...
February 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Siyabulela S B N Ntuli, Wentzel C A Gelderblom, David R Katerere
BACKGROUND: Sutherlandia frutescens (L.) R. Br is endemic to Southern Africa where it has been traditionally used for cancer and diabetes. In recent times it has been marketed for its reputed (but not proven) anticancer, antidiabetic and anti-HIV properties. Little is known about the mutagenic and antimutagenic potential of extracts and common marker compounds of Sutherlandia frutescens. Therefore this study aimed to investigate the putative efficacy and possible long-term adverse effects of using this herb...
March 15, 2018: BMC Complementary and Alternative Medicine
Masumeh Sanaei, Fraidoon Kavoosi, Ali Valiani, Mohamed Amin Ghobadifar
Background: One of the main causes of mortality is hepatocellular carcinoma (HCC) which accounts for the third leading cause of deaths and one in forty deaths worldwide. The flavonoids, natural antioxidant compounds, account for a major group of polyphenolic compounds. One of the major isoflavones in soybean is genistein (GE) which can inhibit proliferation and induce apoptosis. Isoflavones, major type of phenolic materials, derived from dietary plants and medicinal herbs play a significant role in cancer prevention and treatment...
2018: International Journal of Preventive Medicine
Yaqin Zhang, Yi Yuan, Heming Wu, Zhuoying Xie, Yunong Wu, Xiaomeng Song, Jingjing Wang, Wei Shu, Junyong Xu, Bin Liu, Linzhong Wan, Yanan Yan, Xu Ding, Xinghui Shi, Yongchu Pan, Xiaokang Li, Jianrong Yang, Xiaohui Zhao, Lin Wang
Despite significant advances in therapy, the five-year survival rates for patients with advanced stage oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy. Verbascoside (VB), a major bioactive constituent of the Tsoong herb, displays pharmacological properties by exhibiting anti-oxidative, anti-inflammatory, and anti-cancer activities. However, the underlining function and mechanism of VB in human oral squamous cell carcinoma (OSCC) remains unclear...
March 14, 2018: International Journal of Cancer. Journal International du Cancer
Wensheng Zhang, Wanzhuo He, Xiaodong Shi, Xiao Li, Yuanyuan Wang, Minghua Hu, Fangli Ma, Ning Tao, Guiqin Wang, Zhihai Qin
Despite decades of research, malignant tumors are extremely difficult to eliminate with conventional methods. Although surgical resection potentially eradicates the problem, only a few cases are suitable for operation, and other approaches often involve harmful consequences. Revolutionary methods are desperately needed to improve patient outcomes and diminish harmful side effects. Myeloid-derived suppressor cells (MDSCs), downregulators of the innate and adaptive immune systems, have been widely studied over the past 2 decades...
March 13, 2018: Phytotherapy Research: PTR
Furkhan Ahmed Mohammed, Ayman I Elkady, Fareeduddin Quadri Syed, Muqtadir Baig Mirza, Khalid Rehman Hakeem, Saleh Alkarim
ETHNOPHARMACOLOGICAL RELEVANCE: The medicinal herb, Anethum graveolens L. (dill) is one of the potent culinary herbs used as an alternative form of medicine worldwide. The unguent topical Oil from the aerial parts of A. graveolens was found to be effective in the management of uterus cancer in ethnomedicine has been reported. BACKGROUND: The incidence and mortality rates of Hepatocellular carcinoma (HCC) are steadily rising worldwide, especially, in underdeveloped and developing countries...
March 9, 2018: Journal of Ethnopharmacology
Joseph E Gergely, Armond E Dorsey, Goberdhan P Dimri, Manjari Dimri
Polycomb group (PcG) protein BMI1 is an important regulator of oncogenic phenotype and is often overexpressed in several human malignancies including breast cancer. Aberrant expression of BMI1 is associated with metastasis and poor prognosis in cancer patients. At present, therapy reagents that can efficiently inhibit the expression of BMI1 are not very well known. Here, we report that Timosaponin A-III (TA-III), a steroidal saponin obtained from the rhizomes of an herb, Anemarrhena asphodeloides, strongly inhibits expression of BMI1 in breast cancer cells...
March 12, 2018: Molecular Carcinogenesis
Zhao Xiaoxiong, Wang Junmei, Song Yujun, Xinhua Chen
A new methodology has been developed with conjugating nanoparticles (NPs) with an active ingredient of Chinese herbs for nanomedicines with auto-targeting and enhanced magnetic resonance imaging (MRI) for liver cancer therapy. Fe@Fe3 O4 NPs are first synthesized via the programmed microfluidic process, whose surfaces are first modified with -NH2 groups using a silane coupling technique that uses (3-aminopropyl) trimethoxysilane (APTMS) as the coupling reagent and are subsequently activated by the bifunctional amine-active cross-linker (e...
March 12, 2018: Drug Development and Industrial Pharmacy
Jin-Jun Wu, Zhen-Zhen Guo, Yuan-Feng Zhu, Zhi-Jian Huang, Xia Gong, Yu-Huan Li, Wen-Jie Son, Xiao-Yan Li, Yan-Mei Lou, Li-Jun Zhu, Lin-Lin Lu, Zhong-Qiu Liu, Liang Liu
BACKGROUND: Fuzi, which is the processed lateral roots of Aconitum carmichaeli Debx. (Ranunculaceae), is a traditional herbal medicine that is well known for its excellent pharmacological effects and acute toxicity. Aconitum alkaloids are responsible for its pharmacological activity and toxicity. Although a large number of studies on Fuzi have been reported, no comprehensive review on its pharmacokinetics has yet been published. PURPOSE: This paper seeks to present a comprehensive review regarding the phytochemistry, pharmacokinetic features and toxicity of Fuzi...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Ruijuan Zhou, Hongjiu Chen, Junpeng Chen, Xuemei Chen, Yu Wen, Leqin Xu
BACKGROUND: Astragalus membranaceus (AM) is a commonly used herb in traditional Chinese medicine (TCM), which has been used as an essential tonic to treat various diseases for more than 2000 years. In this study, we aimed to investigate the biological effects of extract from AM on breast cancer cell and its mechanism. METHODS: To prepare the extract, dried AM were ground and extracted with water extraction-ethanol supernatant method. Then the main isoflavones in the extract was detect by HPLC analysis...
March 9, 2018: BMC Complementary and Alternative Medicine
Qinhai Ma, Qingtian Yu, Xuefeng Xing, Sinian Liu, Chunyu Shi, Jiabo Luo
The San Wu Huangqin Decoction (SWHD), a traditional Chinese medicine formula, is used to treat colds caused by exposure to wind-pathogen, hyperpyrexia, infectious diseases and cancer; moreover, it is used for detoxification. The individual herbs of SWHD, such as Sophora flavescens and Scutellaria baicalensis , exhibit a wide spectrum of antiviral, anti-inflammatory, antibacterial, anticancer and other properties. The Chinese compound formula of SWHD is composed of S. flavescens, S. baicalensis and Rehmannia glutinosa ...
March 9, 2018: Viruses
Qiang Wang, Jian Mo, Chenchen Zhao, Kangmao Huang, Mingxuan Feng, Wenxin He, Jiying Wang, Shuai Chen, Zi'ang Xie, Jianjun Ma, Shunwu Fan
Bone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast cancer-induced osteolysis and elucidated the possible mechanisms involved in this process. We first verified that RA could suppress osteoclast formation and bone resorption in vitro. Next, we confirmed that RA suppressed Ti-particle-induced osteolysis in a mouse calvarial model, possibly through inhibition of the SRC/AKT signaling pathway...
March 7, 2018: Cell Death & Disease
Talib Hussain, Shrestha Bajpai, Mohd Saeed, Muhammad Amjad Kamal, Ghulam Md Ashraf
There is a long history of traditional medicine for serving world population. For the prevention and treatment of cancer numerous medicinal herbs from entire world including India are being used traditionally. Whenever we talk about treatment of cancer, medicinal plants always have been on the top. For the prevention and treatment of cancer, herbal medicines have played an important role. Countless anticancer plants have been recognized with the help of innovative techniques including isolation and structure elucidation that implement their beneficial effect by increasing immunity of the body, inducing antioxidant action, endorsing making of shielding enzymes, hindering cancer triggering enzymes and hormones, and exciting DNA restoration mechanism...
March 5, 2018: Current Drug Metabolism
She-Fang Huang, Shu-Chen Chu, Yi-Hsien Hsieh, Pei-Ni Chen, Yih-Shou Hsieh
Cancer metastasis is a vital trait in malignancies with complicated early diagnosis and therapeutic management. Therefore, the development of new remedies and the utilization of natural medicines that target metastasis are of great interest and have been studied extensively. Chinese medicinal herbs have various anti-carcinogenesis properties; however, the in vitro effect and mechanism of Viola yedoensis on cancer cell metastasis remains poorly understood. V. yedoensis extracts (VYE) can suppress the invasion of a highly metastatic human lung cancer cell line, A549 cells...
2018: International Journal of Medical Sciences
Suoyuan Li, Tao Zhang, Weiguo Xu, Jianxun Ding, Fei Yin, Jing Xu, Wei Sun, Hongsheng Wang, Mengxiong Sun, Zhengdong Cai, Yingqi Hua
PURPOSE: Osteosarcoma is the most common primary bone cancer and is notorious for pulmonary metastasis, representing a major threat to pediatric patients. An effective drug targeting osteosarcoma and its lung metastasis is urgently needed. DESIGN: In this study, a sarcoma-targeting peptide-decorated disulfide-crosslinked polypeptide nanogel (STP-NG) was exploited for enhanced intracellular delivery of shikonin (SHK), an extract of a medicinal herb, to inhibit osteosarcoma progression with minimal systemic toxicity...
2018: Theranostics
Sadegh Fattahi, Elham Ghadami, Mohsen Asouri, Ali Motevalizadeh Ardekanid, Haleh Akhavan-Niaki
Breast cancer is a heterogeneous and multifactorial disease with variable disease progression risk, and treatment response. Urtica dioica is a traditional herb used as an adjuvant therapeutic agent in cancer. In the present study, we have evaluated the effects of the aqueous extract of Urtica dioica on Adenosine deaminase (ADA) and Ornithine decarboxylase (ODC1) gene expression in MCF-7, MDA-MB-231, two breast cancer cell lines being estrogen receptor positive and estrogen receptor negative, respectively.  Cell lines were cultured in suitable media...
February 28, 2018: Cellular and Molecular Biology
Yu Deng, Fulun Li, Pinglin He, Yafei Yang, Jin Yang, Yamei Zhang, Junying Liu, Yongping Tong, Qingfeng Li, Xian Mei, Zengyi Shu, Qi Zhao
Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune-related diseases over centuries. Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA-damage based chemotherapy drugs in combination with Triptolide treatment. In the present study, we show that a short time exposure (3 hours) to Triptolide,which did not trigger apoptosis, could specifically increase breast cancer cells sensitivity to Doxorubicin rather than other chemotherapy drugs including Paclitaxel, Fluorouracil, and Mitomycin ...
March 3, 2018: Molecular Carcinogenesis
Murat Ozle, Dilek A Uğar Çankal, Mert Ilhan, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVES: Ankaferd BloodStopper® (ABS) is an herbal extract which has been used historically as a hemostatic agent in traditional Turkish medicine. ABS comprises of standardized mixture of herbs Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. In addition to its hemostatic effects, the herb ABS contains some other biological effects including antioxidant and antitumoral properties. The aim of this study is to investigate the chemopreventive effects of ABS in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral epithelial dysplasia...
March 2, 2018: Clinical Oral Investigations
Monika Gorzynik-Debicka, Paulina Przychodzen, Francesco Cappello, Alicja Kuban-Jankowska, Antonella Marino Gammazza, Narcyz Knap, Michal Wozniak, Magdalena Gorska-Ponikowska
Beneficial effects of natural plant polyphenols on the human body have been evaluated in a number of scientific research projects. Bioactive polyphenols are natural compounds of various chemical structures. Their sources are mostly fruits, vegetables, nuts and seeds, roots, bark, leaves of different plants, herbs, whole grain products, processed foods (dark chocolate), as well as tea, coffee, and red wine. Polyphenols are believed to reduce morbidity and/or slow down the development of cardiovascular and neurodegenerative diseases as well as cancer...
February 28, 2018: International Journal of Molecular Sciences
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