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https://www.readbyqxmd.com/read/29328398/synergistic-antitumor-effect-of-brusatol-combined-with-cisplatin-on-colorectal-cancer-cells
#1
Hai-Ming Chen, Zheng-Quan Lai, Hui-Jun Liao, Jian-Hui Xie, Yan-Fang Xian, Yun-Long Chen, Siu-Po Ip, Zhi-Xiu Lin, Zi-Ren Su
Colorectal cancer (CRC) is a common and life‑threatening type of malignant cancer, which is associated with a high mortality rate. Cisplatin (CDDP) is a commonly used chemotherapy drug with significant side effects. Brusatol (BR) is one of the principal chemical compounds isolated from the Chinese herb Bruceae Fructus, which has been reported to markedly inhibit the proliferation of numerous cancer cell lines. The present study aimed to investigate the possible synergistic anticancer effects of CDDP combined with BR on CT‑26 cells, and to evaluate the underlying mechanisms of action...
January 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29322012/inhibition-of-aqueous-extracts-of-solanum-nigrum-aesn-on-oral-cancer-through-regulation-of-mitochondrial-fission
#2
Wu-Ching Uen, Bao-Hong Lee, Yeu-Ching Shi, She-Ching Wu, Chen-Jei Tai, Cheng-Jeng Tai
The present study is designed to investigate the anti-oral cancer properties of Solanum nigrum on oral squamous cell carcinoma. S. nigrum is a Chinese herb used for suppression of various cancers. However, the inhibition of S. nigrum on oral cancer is unclear. Therefore, human oral squamous cancer cells (SCC)-4 were used to evaluate the effect of aqueous extracts of S. nigrum (AESN) on cancer cell proliferation, cell cycle, mitochondrial function and apoptosis. The SCC-4 cells were treated by AESN to evaluate the inhibition of cell proliferation and mitochondrial function in vitro...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321719/cancer-chemoprevention-and-therapy-using-chinese-herbal-medicine
#3
REVIEW
Lijing Jiao, Ling Bi, Yan Lu, Qin Wang, Yabin Gong, Jun Shi, Ling Xu
Traditional Chinese medicine (TCM) plays an indispensable role in cancer prevention and treatment. Chinese herbal medicine (CHM) is a key component of TCM and has been practiced for thousands of years. A number of naturally occurring products from Chinese herbs extracts exhibit strong inhibitory properties against carcinogenesis, including CHM single-herb extracts, CHM-derived active components, and CHM formulas (the polyherbal combinations), which regulate JAK/STAT, MAPK, and NF-ҡB pathways. The present review aims to report the cancer-preventive effect of CHM with evidence from cell-line, animal, epidemiological, and clinical experiments...
2018: Biological Procedures Online
https://www.readbyqxmd.com/read/29318977/inhibition-of-migration-and-invasion-of-hepatocarcinoma-hepg2-cells-by-dietary-saponins-via-targeting-hif-1%C3%AE
#4
Cheng Luo, Di Wu, Glory Magawa, Josephine Omodo, Changfeng Xue, Yanhui Sun, Dequn Liu, Chong Xie, Yaqin Wang, Christopher Frenz, Shanggui Deng
Different saponins from herbs have been used as tonic or functional foods, and for treatment of various diseases including cancers. Although clinical data has supported the function of these saponins, their underlying molecular mechanisms have not been well defined. With the simulated hypoxia created by 8 hours of Cu++ exposure and following 24 hour incubation with different concentration of saponins in HepG2 cells, ZC-4 had the highest rate of inhibition of cell proliferation by MTT assay, and the highest inhibition of migration rate by in vitro scratch assay, while ZC-3 had the highest inhibition of invasion ratio by transwell assay...
January 10, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29316796/scutellaria-baicalensis-and-cancer-treatment-recent-progress-and-perspectives-in-biomedical-and-clinical-studies
#5
Chien-Shan Cheng, Jie Chen, Hor-Yue Tan, Ning Wang, Zhen Chen, Yibin Feng
Scutellaria baicalensis (Huangqin in Chinese) is a major traditional Chinese medicine (TCM) herb, which has a long history of use in the treatment of a variety of symptoms correlated with cancer. In the past decade, the potential of S. baicalensis and single compounds derived from it as anticancer agents targeting various pathways has received extensive research attention. Specifically, the proliferation and metastases inhibiting properties of the single compounds in cancer have been studied; however, the underlying mechanisms remain unclear...
January 9, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29312612/the-anti-cancer-effects-and-mechanisms-of-scutellaria-barbata-d-don-on-cl1-5-lung-cancer-cells
#6
Chin-Chuan Chen, Chun-Pin Kao, Mei-Miao Chiu, Shu-Huei Wang
Lung cancer, with a poor prognosis and resistance to chemotherapy, is the most common malignant tumor and has the highest mortality rate worldwide. Scutellaria barbata D. Don (SB), which is derived from the dried whole plant of Labiatae, is a well-known anti-inflammatory and anti-cancer herb. The aim of this study was to examine the anti-cancer effects and precise regulatory mechanisms of SB in CL1-5 lung cancer cells. In an in vitro assay, we found that the anti-tumor mechanism of SB was due to P38/SIRT1-regulated cell apoptosis through G2/M phase arrest and ER stress-, intrinsic mitochondrial-, and extrinsic FAS/FASL-mediated pathways...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298734/ailanthone-promotes-human-vestibular-schwannoma-cells-apoptosis-and-autophagy-by-down-regulation-of-mir-21
#7
Peizhen Yang, Dechong Sun, Fei Jiang
Ailanthone (AIL) is a quassinoid isolated from the traditional Chinese medicinal herb Ailanthus altissima. The anti-tumor activities of AIL have been reported in several cancers. The purpose of the present study was to explore the effect of AIL on vestibular schwannomas (VSs). Various concentration of AIL (0~1 μM) was used to treat human primary VS cells, and then cell viability, proliferation, apoptosis, and autophagy were assessed, respectively. Expression of miR-21 in VS cells was altered by miRNA transfection...
January 3, 2018: Oncology Research
https://www.readbyqxmd.com/read/29298656/pre-clinical-validation-of-mito-targeted-nano-engineered-flavonoids-isolated-from-selaginella-bryopteris-sanjeevani-as-a-novel-cancer-prevention-strategy
#8
Arpit Bhargava, Neelam Pathak, Sriram Seshadri, Neha Bunkar, Subodh Kumar Jain, Dinesh Mishra Kumar, Nirmal Kumar Lohiya, Pradyumna Kumar Mishra
BACKGROUND: Novel bioactive plant secondary metabolites, including flavonoids, offer a spectrum of chemo-protective responses against a range of human tumor models. However, the clinical translation of these promising anti-cancer agents has been hindered largely by their poor solubility, rapid metabolism, or a combination of both, ultimately resulting in poor bioavailability upon oral administration. OBJECTIVE: To circumvent the challenges associated with herbal drug development and for effective integration into clinical setting, nano-engineering is one of the emerging pragmatic strategy which has promise to deliver therapeutic concentrations of bio-actives upon oral administration...
December 29, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29295501/the-herb-drug-pharmacokinetic-interaction-of-5-fluorouracil-and-its-metabolite-5-fluoro-5-6-dihydrouracil-with-a-traditional-chinese-medicine-in-rats
#9
Ju-Han Liu, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
BACKGROUND: Xiang-Sha-Liu-Jun-Zi-Tang (XSLJZT) is the most common traditional formula given to colorectal and breast cancer patients in Taiwan, according to a statistical study of the National Health Insurance Research Database. 5-Fluorouracil (5-FU) is widely used as the first line of treatment for colorectal cancer. Thus, the aim of study is to investigate the pharmacokinetic interaction of XSLJZT and 5-FU. METHODS: To investigate the herb-drug interaction of XSLJZT with 5-FU as well as its metabolite 5-fluoro-5,6-dihydrouracil (5-FDHU) using pharmacokinetics, a high-performance liquid chromatography (HPLC) system coupled with a photodiode array detector was developed to monitor 5-FU and 5-FDHU levels in rat blood...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29285297/identification-of-wt1-as-determinant-of-heptatocellular-carcinoma-and-its-inhibition-by-chinese-herbal-medicine-salvia-chinensis-benth-and-its-active-ingredient-protocatechualdehyde
#10
Ning Wang, Hor-Yue Tan, Yau-Tuen Chan, Wei Guo, Sha Li, Yibin Feng
Candidates from Chinese herbal Medicine might be preferable in drug discovery as the abundant experiences of traditional use usually hint the clinical efficacy. In this study, we screened the anti-tumour effect of several commonly used Chinese herbal Medicines on human hepatocellular carcinoma cells (HCC). We identified that Salvia chinensia Benth. (Shijianchuan in Chinese, SJC) exhibited prominent in vitro inhibition of HCC cells and suppressed the orthotopic growth of HCC in the liver of mice and repressed the lung metastasis of tumour cells...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285087/scutellaria-barbata-d-don-inhibits-migration-and-invasion-of-colorectal-cancer-cells-via-suppression-of-pi3k-akt-and-tgf-%C3%AE-smad-signaling-pathways
#11
Yiyi Jin, Wujin Chen, Hong Yang, Zhaokun Yan, Zijun Lai, Jianyu Feng, Jun Peng, Jiumao Lin
Metastasis is one of the most aberrant behaviors of cancer cells. Patients with cancers, including colorectal cancer (CRC), have a higher risk of tumor recurrence and cancer-related mortality once metastasis is diagnosed. Existing treatment strategies fail to cure cancer mostly due to the onset of metastasis. Therefore, metastasis remains a challenge in cancer treatment. Some complementary and alternative medical therapies using traditional Chinese medicine have been demonstrated to be clinically effective in cancer treatment...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29278371/flavonoids-and-phenolic-acids-from-oregano-occurrence-biological-activity-and-health-benefits
#12
REVIEW
Erick P Gutiérrez-Grijalva, Manuel A Picos-Salas, Nayely Leyva-López, Marilyn S Criollo-Mendoza, Gabriela Vazquez-Olivo, J Basilio Heredia
Several herb species classified as oregano have been widely used in folk medicine to alleviate inflammation-related diseases, respiratory and digestive disorders, headaches, rheumatism, diabetes and others. These potential health benefits are partially attributed to the phytochemical compounds in oregano such as flavonoids (FL) and phenolic acids (PA). Flavonoids and phenolic acids are among the most abundant and most studied phytochemicals in oregano species. Epidemiological, in vitro and in vivo experiments have related long-term consumption of dietary FL and PA with a decreased risk of incidence of chronic diseases...
December 26, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29277460/aconitum-alkaloids-the-major-components-of-aconitum-species-affect-expression-of-multidrug-resistance-associated-protein-2-and-breast-cancer-resistance-protein-by-activating-the-nrf2-mediated-signalling-pathway
#13
Jin-Jun Wu, Yuan-Feng Zhu, Zhen-Zhen Guo, Yan-Mei Lou, Shu-Gui He, Yang Guan, Li-Jun Zhu, Zhong-Qiu Liu, Lin-Lin Lu, Liang Liu
BACKGROUND: Aconitum alkaloids from Aconitum species are often used to treat arthritis and rheumatic diseases but have the drawback of high toxicity. Identifying their pharmacokinetic behaviour is important for the safe clinical application of Aconitum species. Efflux transporters (ETs), including P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP), have important functions in regulating the pharmacokinetic behaviours of drugs and in herb-herb or herb-drug interactions (HDIs)...
December 8, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29247770/apigenin-promotes-trail-mediated-apoptosis-regardless-of-ros-generation
#14
Chang-Hee Kang, Ilandarage Menu Neelaka Molagoda, Yung Hyun Choi, Cheol Park, Dong-Oh Moon, Gi-Young Kim
Apigenin is a bioactive flavone in several herbs including parsley, thyme, and peppermint. Apigenin possesses anti-cancer and anti-inflammatory properties; however, whether apigenin enhances TRAIL-mediated apoptosis in cancer cells is unknown. In the current study, we found that apigenin enhanced TRAIL-induced apoptosis by promoting caspase activation and death receptor 5 (DR5) expression and a chimeric antibody against DR5 completely blocked the apoptosis. Apigenin also upregulated reactive oxygen species (ROS) generation; however, intriguingly, ROS inhibitors, glutathione (GSH) or N-acetyl-l-cysteine (NAC), moderately increased apigenin/TRAIL-induced apoptosis...
December 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29234362/chinese-herbal-medicine-as-an-adjunctive-therapy-ameliorated-the-incidence-of-chronic-hepatitis-in-patients-with-breast-cancer-a-nationwide-population-based-cohort-study
#15
Kuo-Chin Huang, Hung-Rong Yen, Jen-Huai Chiang, Yuan-Chih Su, Mao-Feng Sun, Hen-Hong Chang, Sheng-Teng Huang
We conducted a National Health Insurance Research Database-based Taiwanese nationwide population-based cohort study to evaluate whether Chinese herbal medicine (CHM) treatment decreased the incidence of chronic hepatitis in breast cancer patients receiving chemotherapy and/or radiotherapy. A total of 81171 patients were diagnosed with breast cancer within the defined study period. After randomly equal matching, data from 13856 patients were analyzed. Hazard ratios of incidence rate of chronic hepatitis were used to determine the influence and therapeutic potential of CHM in patients with breast cancer...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29225515/anticancer-activity-of-astragalus-polysaccharide-in-human-non-small-cell-lung-cancer-cells
#16
Chao-Yan Wu, Yuan Ke, Yi-Fei Zeng, Ying-Wen Zhang, Hai-Jun Yu
Background: We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesis, growth, development and metastasis of cancer. NF-κB is also involved in the development of treatment resistance in tumors. Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29215592/natural-korean-medicine-dang-gui-biosynthesis-effective-extraction-and-formulations-of-major-active-pyranocoumarins-their-molecular-action-mechanism-in-cancer-and-other-biological-activities
#17
REVIEW
Chinreddy Subramanyam Reddy, Seong Cheol Kim, Mok Hur, Yeon Bok Kim, Chun Geon Park, Woo Moon Lee, Jae Ki Jang, Sung Cheol Koo
Angelica gigas Nakai (AGN) is a crucial oriental medicinal herb that grows especially in Korea and the Far-East countries. It contains chemically active compounds like pyranocoumarins, polyacetylenes and essential oils, which might be useful for treatment of several chronic diseases. It has been used for centuries as a traditional medicine in Southeast Asia, but in Western countries is used as a functional food and a major ingredient of several herbal products. The genus Angelica is also known as 'female ginseng' due to its critical therapeutic role in female afflictions, such as gynecological problems...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29212474/coptis-chinensis-affects-the-function-of-glioma-cells-through-the-down-regulation-of-phosphorylation-of-stat3-by-reducing-hdac3
#18
Jiangan Li, Lulu Ni, Bing Li, Mingdeng Wang, Zhemin Ding, Chunrong Xiong, Xiaojie Lu
BACKGROUND: Glioma remains the most common cause of brain cancer-related mortality. Glioma accounts for 50-60% of brain cancer. Due to their low toxicity and infrequent side effects, traditional herbs have been increasingly popular. Coptis Chinensis is commonly used in cancer treatment in combination with other Chinese Medicine herbs. However, little is known about its biological functions and mechanisms in glioma cells. METHODS: In this study, the anti-glioma cell effect of Coptis Chinensis was determined using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) method, plate clone test, scratch tests, flow cytometry, western blotting and a glioma xenograft tumor model...
December 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29202738/effects-of-mistletoe-products-on-pharmacokinetic-drug-turnover-by-inhibition-and-induction-of-cytochrome-p450-activities
#19
Michael Schink, Oliver Dehus
BACKGROUND: European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe therapy. METHODS: Three European mistletoe products (Helixor® A, Helixor® M and Helixor® P from mistletoe grown on firs, apple trees and pines, respectively) were tested for inhibition of nine major cytochrome P450 (CYP) isoenzymes in a test system using pooled human liver microsomes and for induction of five CYP isoforms in human hepatocytes cultivated in vitro according to the relevant guideline...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29201097/the-evaluation-and-comparing-of-cytotoxic-effects-of-ferula-gummosa-gum-scutellaria-lindbergii-kelussia-odoratissima-and-artemisia-kopetdaghensis-extracts-on-achn-cell-line
#20
Azar Hosseini, Elham Bakhtiari, Abolfazl Khajavi Rad, Samira Shahraki, Seyed Hadi Mousavi, Shahrzad Havakhah, Mohammad Sadegh Amiri
Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients it is resistant to chemotherapy. Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima, and Artemisia kopetdaghensis are herbs about which there are some cytotoxic activity reports. In this study, cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN) were evaluated and compared (ACHN) cells were treated with different concentrations of herbal extracts (15-500 μg/mL). Cell proliferation was determined after 24, 48, and 72 h...
2017: Iranian Journal of Pharmaceutical Research: IJPR
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