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https://www.readbyqxmd.com/read/28545191/%C3%A2-mate%C3%A2-intake-hormone-based-risk-factors-and-breast-cancer-a-case-control-study
#1
Alvaro L Ronco, Edison Espinosa, Juan M Calderon, Eduardo Lasalvia- Galante, Alejandro De Rosa, Gustavo Sanchez
Previous reports on the inverse association between ‘mate’ intake (infusion of Ilex Paraguariensis herb) and breast cancer (BC) risk led us to consider two main roles for the infusion: as a substantial antioxidant contributor and as a hormone regulator, particularly through anti-aromatase capacities. Since menstrual-reproductive risk factors for BC reflect women’s estrogenic exposure during the reproductive lifespan, and considering that ‘mate’ intake exerts putative stronger protection among high antioxidant contributors, we attempted to analyze interactions among the infusion, hormon-linked reproductive factors and BC risk, which have hitherto remained unexplored...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28543959/epidemiology-of-urothelial-carcinoma
#2
REVIEW
Jun Miyazaki, Hiroyuki Nishiyama
The epithelium lining is defined as the mucosal surfaces of the renal collecting tubules, calyces and pelvis, as well as the ureter, bladder and urethra. The term "urothelium" is used to refer to these surfaces. Upper tract urothelial carcinoma is a rare subset of urothelial cancers with a poor prognosis. Urinary bladder cancer is the most common malignancy involving the urinary system. Upper tract urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2:1. The incidence of urinary bladder cancer is also higher in men...
May 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28539822/induction-of-mitotic-delay-in-pharyngeal-and-nasopharyngeal-carcinoma-cells-using-an-aqueous-extract-of-ajuga-bracteosa
#3
Yu-Tsai Lin, Chih-Che Lin, Hung-Chen Wang, Yi-Chiang Hsu
Nasopharyngeal carcinoma (NPC) is a common cancer in Southeast Asia, for which radiotherapy and/or chemotherapy are the primary treatment methods. Many herbs are known to have potential uses in chemotherapy; however, the mechanisms underlying the observed antitumor activity of Ajuga bracteosa (AB) against NPC remain unclear. We explored the antitumor effects of AB, which was shown specifically to induce mitotic delay in pharyngeal (Detroit 562) and nasopharyngeal (Hone-1) cancer cells. Proliferation of cancer cells after exposure to aqueous extract of A...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28539747/botanical-and-chemical-fingerprinting-of-medicinal-roots-of-justicia-gendarussa-burm-f
#4
Deepa Yadav, Mohd Salim Reshi, Chhavi Uthra, Sadhana Shrivastava, Nalini Srivastava, Sunil Kumar Koppala Narayana, Sangeeta Shukla
BACKGROUND: Justicia gendarussa Burm f. of family Acanthaceae is medicinally important herb used in the treatment of inflammatory disorders, asthma, hepatic injuries, pathogenic infection and also shows antiproliferative activity against various cancer cell lines. MATERIALS AND METHODS: Pharmacognostical evaluation (macro-microscopy, physicochemical analysis and preliminary phytochemical analysis), high-performance thin layer chromatography (HPTLC) fingerprinting and chemical profiling by gas chromatography-mass spectrometry (GCMS) of dried roots of J...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28534941/two-natural-eudesmane-type-sesquiterpenes-from-laggera-alata-inhibit-angiogenesis-and-suppress-breast-cancer-cell-migration-through-vegf-and-angiopoietin-2-mediated-signaling-pathways
#5
Ning Liang, Yaolan Li, Hau Yin Chung
Eudesmane-type sesquiterpenes are natural sesquiterpenes with anti-inflammatory properties, but their anti-angiogenic activities are not known. The present study demonstrated that 5α-hydroxycostic acid and hydroxyisocostic acid, two eudesmane-type sesquiterpenes (ETSs), isolated from the herb Laggera alata, possessed anti-angiogenic effects. Under non-toxic dosage, ETSs suppressed VEGF‑induced proliferation in human umbilical vein endothelial cells (HUVECs) and vessel formation in zebrafish embryos. Moreover, ETSs inhibited VEGF-stimulated HUVEC migration, stress fibers and tube formation...
May 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28529560/ruanjian-sanjie-decoction-exhibits-antitumor-activity-by-inducing-cell-apoptosis-in-breast-cancer
#6
Xiumei Zhao, Jing Zhao, Renjie Hu, Qiang Yao, Guixian Zhang, Hongsheng Shen, Ernesto Yagüe, Yunhui Hu
Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and Hai zao (Sargassum pallidum), and has traditionally been used for softening hard lumps and resolving hard tissue masses...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28523296/a-systematic-review-of-the-possible-carcinogenic-role-of-the-aristolochic-acid
#7
Tivadar Bara, Simona Gurzu, Haruhiko Sugimura, Tivadar Bara, Marius Alexandru Beleaua, Ioan Jung
Aristolochic acid (AA) is a bioactive component of Chinese herbs, dietary supplements, slimming pills and contaminated flour, which is known to induce chronic tubulointerstitial disease. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma (UTUC) and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis. Twenty representative papers were selected for this review...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28507944/a-survey-on-phytochemical-composition-and-biological-activity-of-zygophyllum-fabago-from-iran
#8
Saeid Yaripour, Mohammad-Reza Delnavazi, Parina Asgharian, Samira Valiyari, Saeed Tavakoli, Hossein Nazemiyeh
Purpose: Zygophyllum fabago L. (Z. fabago) is a widespread perennial herb which is used as a medicinal plant in traditional medicine of Iran, Turkey and China. The present study was a survey on phytochemical constituents and biological activities of this plant. Methods: Methanolic extract of the roots was fractionated over a C-18 pre-packed cartridge (Sep-pak) and chromatographic separation was performed on a reversed-phase preparative HPLC. Structural elucidation of the isolated compounds was carried out using UV, (1)H-NMR and 13C-NMR spectral analyses...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28507311/disruption-of-shh-signaling-cascade-by-sbe-attenuates-lung-cancer-progression-and-sensitizes-ddp-treatment
#9
Jing Du, Weiwei Chen, Lijuan Yang, Juanjuan Dai, Jiwei Guo, Yan Wu, Kaikai Gong, Jian Zhang, Ning Yu, Zhen Xie, Sichuan Xi
Deregulated Sonic Hedgehog (SHH) pathway facilitates the initiation, progression, and metastasis of Non-small cell lung cancer (NSCLC), confers drug resistance and renders a therapeutic interference option to lung cancer patients with poor prognosis. In this study, we screened and evaluated the specificity of a Chinese herb Scutellariabarbata D. Don extraction (SBE) in repressing SHH signaling pathway to block NSCLC progression. Our study confirmed that aberrant activation of the SHH signal pathway conferred more proliferative and invasive phenotypes to human lung cancer cells...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506259/detection-of-antibacterial-activities-of-miswak-kalonji-and-aloe-vera-against-oral-pathogens-anti-proliferative-activity-against-cancer-cell-line
#10
Sameen Amjed, Kashaf Junaid, Junaid Jafar, Tuaha Amjad, Waqas Maqsood, Nadia Mukhtar, Kanza Tariq, Musarrat Sharif, Sana Javaid Awan, Farheen Ansari
BACKGROUND: Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infections around the world. The medical potentials of a lot of Pakistani local herbs and herbal combinations is relatively unknown, hence attempted to explore. A study was designed to investigate potential role of local medicinal herbs for example Miswak, Kalonji & Aloe vera as antimicrobial, antioxidant and anti-proliferative agents against oral pathogens and cancer cell line...
May 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28503147/an-ethanolic-extract-of-ampelopsis-radix-exerts-anti-colorectal-cancer-effects-and-potently-inhibits-stat3-signaling-in-vitro
#11
Tao Su, Jing-Xuan Bai, Ying-Jie Chen, Xin-Ning Wang, Xiu-Qiong Fu, Ting Li, Hui Guo, Pei-Li Zhu, Yue Wang, Zhi-Ling Yu
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in CRC, and has been proposed as a pathogenic factor and a therapeutic target of CRC. Ampelopsis Radix (AR), a traditional Chinese medicinal herb, possesses low toxicity and has long been used clinically for the treatment of cancers including CRC. Some constituents of AR have been reported to exert anti-cancer properties by targeting STAT3...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28503089/anticancer-chemodiversity-of-ranunculaceae-medicinal-plants-molecular-mechanisms-and-functions
#12
REVIEW
Da-Cheng Hao, Chun-Nian He, Jie Shen, Pei-Gen Xiao
The buttercup family, Ranunculaceae, comprising more than 2,200 species in at least 62 genera, mostly herbs, has long been used in folk medicine and worldwide ethnomedicine since the beginning of human civilization. Various medicinal phytometabolites have been found in Ranunculaceae plants, many of which, such as alkaloids, terpenoids, saponins, and polysaccharides, have shown anti-cancer activities in vitro and in vivo. Most concerns have been raised for two epiphany molecules, the monoterpene thymoquinone and the isoquinoline alkaloid berberine...
February 2017: Current Genomics
https://www.readbyqxmd.com/read/28496485/phytochemicals-antioxidant-and-antiproliferative-properties-of-rosmarinus-officinalis-l-on-u937-and-caco-2-cells
#13
Yacine Amar, Boumediene Meddah, Irene Bonacorsi, Gregorio Costa, Gaetana Pezzino, Antonina Saija, Mariateresa Cristani, Soulef Boussahel, Guido Ferlazzo, Aicha Tirtouil Meddah
Rosmarinus officinalis L., a medicinal herb from the labiates family, has been reported to have potential benefit in the treatment and prevention of several diseases. In particular its phenolics have demonstrated protective effects on various types of cancer through several mechanisms. The present study aimed to determine the effects of rosemary phenolic extracts on human cell functions, with particular regard to their anti-proliferative properties in three cell types U937, CaCo-2 and the peripheral blood mononuclear cells (PBMCs)...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28494850/efficacy-of-a-traditional-persian-medicine-preparation-for-radiation-induced-xerostomia-a-randomized-open-label-active-controlled-trial
#14
Ghazaleh Heydarirad, Hossein Rezaeizadeh, Rasool Choopani, Seyed Hamdollah Mosavat, Ahmad Ameri
BACKGROUND: Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers (HNC). However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE: Synthesizing the traditional use of Alcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life (QOL) of HNC patients with radiation-induced xerostomia...
May 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28490965/protective-effects-of-fennel-oil-extract-against-sodium-valproate-induced-hepatorenal-damage-in-albino-rats
#15
Wael M Al-Amoudi
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28484391/quantitative-evaluation-of-the-compatibility-effects-of-huangqin-decoction-on-the-treatment-of-irinotecan-induced-gastrointestinal-toxicity-using-untargeted-metabolomics
#16
Dong-Ni Cui, Xu Wang, Jia-Qing Chen, Bo Lv, Pei Zhang, Wei Zhang, Zun-Jian Zhang, Feng-Guo Xu
Huangqin decoction (HQD), a traditional Chinese medicine (TCM), has been widely used to treat gastrointestinal syndrome in China for thousands of years. Chemotherapy drug irinotecan (CPT-11) is used clinically to treat various kinds of cancers but limited by its side effects, especially delayed diarrhea. Nowadays, HQD has been proved to be effective in attenuating the intestinal toxicity induced by CPT-11. HQD consists of four medicinal herbs including Scutellaria baicalensis Georgi, Glycyrrhiza uralensis Fisch, Paeonia lactiflora Pall, and Ziziphus jujuba Mill...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28482859/an-ethnopharmacological-evaluation-of-navapind-and-shahpur-virkanin-district-sheikupura-pakistan-for-their-herbal-medicines
#17
Maria Zahoor, Zubaida Yousaf, Tahreem Aqsa, Manahil Haroon, Nadia Saleh, Arusa Aftab, Sadia Javed, Mouzma Qadeer, Habiba Ramazan
BACKGROUND: The chief aim of this study was to enlist the ethnobotanical uses of wild plants in district Sheikhupura, province Punjab, Pakistan. Due to extreme geographical and climatic conditions, Pakistan has a great floral diversity. Plants have been used by the indigenous people for treatment of different ailments since long. They are still dependent on the plants for their domestic purposes. Moreover, plants are used as first aid to treat diverse ailments such as cold, cough, influenza, asthma, cancer, antidote, gastric and hepatic disorders...
May 8, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28480435/the-herbal-mixture-xiao-chai-hu-tang-xcht-induces-apoptosis-of-human-hepatocellular-carcinoma-huh7-cells-in-vitro-and-in-vivo
#18
Jinyan Zhao, Liya Liu, Yuchen Zhang, Yun Wan, Zhenfeng Hong
BACKGROUND: Xiao-Chai-Hu Tang (XCHT) is an extract of seven herbs with anticancer properties, but its mechanism of action is unknown. In this study, we evaluated XCHT-treated hepatocellular carcinoma (HCC) for anti-proliferative and pro-apoptotic effects. MATERIALS AND METHODS: Using a hepatic cancer xenograft model, we investigated the in vivo efficacy of XCHT against tumor growth by evaluating tumor volume and weight, as well as measuring apoptosis and cellular proliferation within the tumor...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28479720/in-vitro-anti-proliferative-effect-of-tephrosia-purpurea-on-human-hepatocellular-carcinoma-cells
#19
Ramamoorthy Padmapriya, Loganathan Gayathri, Larance Ronsard, Mohammad A Akbarsha, Ramasamy Raveendran
BACKGROUND: Tephrosia purpurea is an Indian herb used in traditional medicine to treat various diseases such as jaundice, asthma, liver and urinary disorders. However, the anti-cancer potential of T. purpurea on hepatocellular carcinoma (HCC) is poorly understood. Therefore, this study aims to investigate the anti-cancer activity of T. purpurea in HepG2 hepatocellular carcinoma cells. METHODS: The leaves and root of T. purpurea were extracted with methanol using soxhlet apparatus...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28476678/anticancer-efficacy-of-the-ethyl-acetate-extract-from-the-traditional-chinese-medicine-herb-celastrus-orbiculatus-against-human-gastric-cancer
#20
Haibo Wang, Lide Tao, Tengyang Ni, Hao Gu, Feng Jin, Xiaojun Dai, Jun Feng, Yanbing Ding, Weiming Xiao, Shiyu Guo, Tadashi Hisamitsu, Yayun Qian, Yanqing Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese medicine (TCM) herb Celastrus orbiculatus is an important folk medicinal plant in China that has been used as an anti-inflammatory, antitumor, and analgesic in various diseases. The ethyl acetate extract of C. orbiculatus (C. orbiculatus extract, COE) was reported to show significant antitumor effects. However, no study in China or abroad has reported the effect and mechanism of COE in triggering apoptosis of gastric cancer (GC) cells...
May 2, 2017: Journal of Ethnopharmacology
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