keyword
MENU ▼
Read by QxMD icon Read
search

Cancer AND herbs

keyword
https://www.readbyqxmd.com/read/29143796/angelica-sinensis-polysaccharides-ameliorate-stress-induced-premature-senescence-of-hematopoietic-cell-via-protecting-bone-marrow-stromal-cells-from-oxidative-injuries-caused-by-5-fluorouracil
#1
Hanxianzhi Xiao, Lirong Xiong, Xiaoying Song, Pengwei Jin, Linbo Chen, Xiongbin Chen, Hui Yao, Yaping Wang, Lu Wang
Myelosuppression is the most common complication of chemotherapy. Decline of self-renewal capacity and stress-induced premature senescence (SIPS) of hematopoietic stem cells (HSCs) induced by chemotherapeutic agents may be the cause of long-term myelosuppression after chemotherapy. Whether the mechanism of SIPS of hematopoietic cells relates to chemotherapeutic injury occurred in hematopoietic microenvironment (HM) is still not well elucidated. This study explored the protective effect of Angelica sinensis polysaccharide (ASP), an acetone extract polysaccharide found as the major effective ingredients of a traditional Chinese medicinal herb named Chinese Angelica (Dong Quai), on oxidative damage of homo sapiens bone marrow/stroma cell line (HS-5) caused by 5-fluorouracil (5-FU), and the effect of ASP relieving oxidative stress in HM on SIPS of hematopoietic cells...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29143759/the-role-of-food-antioxidants-benefits-of-functional-foods-and-influence-of-feeding-habits-on-the-health-of-the-older-person-an-overview
#2
REVIEW
Douglas W Wilson, Paul Nash, Harpal Singh Buttar, Keith Griffiths, Ram Singh, Fabien De Meester, Rie Horiuchi, Toru Takahashi
This overview was directed towards understanding the relationship of brain functions with dietary choices mainly by older humans. This included food color, flavor, and aroma, as they relate to dietary sufficiency or the association of antioxidants with neurodegenerative diseases such as dementia and Alzheimer's disease. Impairment of olfactory and gustatory function in relation to these diseases was also explored. The role of functional foods was considered as a potential treatment of dementia and Alzheimer's disease through inhibition of acetylcholinesterase as well as similar treatments based on herbs, spices and antioxidants therein...
October 28, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29140496/association-between-use-of-traditional-chinese-medicine-herbal-therapy-and-survival-outcomes-in-patients-with-stage-ii-and-iii-colorectal-cancer-a-multicenter-prospective-cohort-study
#3
Yun Xu, Jun J Mao, Lingyun Sun, Lin Yang, Jie Li, Yingxu Hao, Huashan Li, Wei Hou, Yuping Chu, Yu Bai, Xiaoqiang Jia, Jinwan Wang, Lin Shen, Ying Zhang, Jianbin Wang, Jianping Liu, Yufei Yang
Background: Chinese cancer patients often use Traditional Chinese Medicine (TCM) herbal medicine during or after active cancer treatments. However, little is known about how TCM herbal medicine impacts cancer outcomes. This study aimed to evaluate the association between TCM herbal therapy and survival outcomes in patients with stage II or III colorectal cancer. Methods: We conducted an eight-center prospective cohort study in China among patients who had undergone radical resection for stage II and III colorectal cancer...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29140485/growth-of-integrative-medicine-at-leading-cancer-centers-between-2009-and-2016-a-systematic-analysis-of-nci-designated-comprehensive-cancer-center-websites
#4
Hyeongjun Yun, Lingyun Sun, Jun J Mao
Background: Cancer centers have increasingly offered integrative medicine therapies in response to their patients' unmet needs. We evaluated the growth of integrative medicine in leading academic cancer centers in the United States as reflected by their public-facing websites. Methods: We performed a systematic review of 45 National Cancer Institute (NCI)-designated comprehensive cancer center websites. Two researchers independently evaluated whether the websites provided information regarding integrative medicine modalities and, if so, whether the services were provided in the same health system...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29139271/-studies-on-the-chemical-components-of-nelumbinis-plumula-and-the-inhibitory-activity-on-protein-disulfide-isomerase
#5
Yong Yang, Xi-Zhen Li, Qing-He Zhang, Dan Lu
Increasing evidence suggested that protein disulfide isomerase supported the survival and progression of several cancers. Nelumbinis Plumula is a Chinese traditional herb which showed antitumor activity. To find if the Nelumbinis Plumula affect protein disulfide isomerase activity, we studied its chemical constituents, and 12 monomeric compounds were isolated by means of solvent extraction, silica gel column chromatography, preparative HPLC and recrystallization. Among them, N-methylcoclaurine, kaempferol, chrysoeriol-7-O-neohesperidoside and mannitol were obtained for the first time...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29138518/predicted-molecular-targets-and-pathways-for-germacrone-curdione-and-furanodiene-in-the-treatment-of-breast-cancer-using-a-bioinformatics-approach
#6
Qi Kong, Yong Ma, Jie Yu, Xiuping Chen
Germacrone, curdione, and furanodiene have been shown to be useful in the treatment of breast cancer but the pharmacological mechanism of action is unclear. In this paper, we explored a new method to study the molecular network and function of Traditional Chinese Medicine (TCM) herbs and their corresponding ingredients with bioinformatics tools, including PubChem Compound Database, BATMAN-TCM, SystemsDock, Coremine Medical, Gene ontology, and KEGG. Eleven targeted genes/proteins, 4 key pathways, and 10 biological processes were identified to participate in the mechanism of action in treating breast cancer with germacrone, curdione, and furanodiene...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130495/matrine-reversed-multidrug-resistance-of-breast-cancer-mcf-7-adr-cells-through-pi3k-akt-signal-pathway
#7
Bing-Gang Zhou, Chang-Sheng Wei, Song Zhang, Zhi Zhang, Huan-Min Gao
Matrine is an alkaloid extracted from a Chinese herb Sophora flavescens Ait, and has been used clinically for breast cancer with marked therapeutic efficacy in China. However, the mechanism has not been well known. Thus the present study was to explore if Matrine reverse multidrug resistance for breast cancer cells though regulating PI3K/AKT signal pathway. Methyl thiazolyl tetrazolium (MTT) assay was used to detect the inhibitory action; Annexin V to detect apoptosis; Fluorospectrophotometry to examine intracellular adriamycin (ADR) accumulation and Western-blot to label the proteins of P-glycoprotein(P-gp), MRP1, PTEN, p-AKT, Bcl-2, Bax and Caspase-3...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29129665/intravasation-of-sw620-colon-cancer-cell-spheroids-through-the-blood-endothelial-barrier-is-inhibited-by-clinical-drugs-and-flavonoids-in-vitro
#8
Silvio Holzner, Stefan Brenner, Atanas Georgiev Atanasov, Daniel Senfter, Serena Stadler, Chi Huu Nguyen, Adryan Fristiohady, Daniela Milovanovic, Nicole Huttary, Sigurd Krieger, Zsuzsanna Bago-Horvath, Oliver de Wever, Ioannis Tentes, Ali Özmen, Walter Jäger, Helmut Dolznig, Verena Maria Dirsch, Robert Michael Mader, Liselotte Krenn, Georg Krupitza
Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell (BEC) barrier breaching by CRC emboli, an in vitro assay measuring BEC-free areas underneath SW620 cell spheroids, so called "circular chemorepellent induced defects" (CCIDs, appearing in consequence of endothelial retraction), was adapted and supported by Western blotting, EIA-, EROD- and luciferase reporter assays. Inhibition of ALOX12 or NF-κB in SW620 cells or BECs, respectively, caused attenuation of CCIDs...
November 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29115601/ginsenoside-rg3-targets-cancer-stem-cells-and-tumor-angiogenesis-to-inhibit-colorectal-cancer-progression-in-vivo
#9
Yu-Chen Tang, Yan Zhang, Jin Zhou, Qiaoming Zhi, Meng-Yao Wu, Fei-Ran Gong, Meng Shen, Lu Liu, Min Tao, Bairong Shen, Dong-Mei Gu, Jie Yu, Meng-Dan Xu, Yuan Gao, Wei Li
Anti-angiogenic therapy has been successfully applied to treat colorectal cancer (CRC). Ginsenoside Rg3, derived from the Chinese herb ginseng, has anti-vascularization effects and can inhibit tumor growth and metastasis, and can sensitize cancer cells to chemotherapy. Therefore, in the present study, we investigated whether Rg3 could be appropriate for CRC treatment. Growth of CRC cells was assessed by an MTT (methyl thiazolyl tetrazolium) assay in vitro and using orthotopic xenograft models in vivo. mRNA expression was evaluated using real-time PCR...
November 1, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113957/ecological-observations-and-altered-indigenous-harvesting-practices-of-trillium-govanianum-melanthiaceae-in-indian-himalayas
#10
Harsh K Chauhan, Anil K Bisht, Indra D Bhatt, Arvind Bhatt, David Gallacher, Andrea Santo
ETHANOBOTANICAL RELEVANCE: Trillium govanianum Wall. ex D. Don (Melanthiaceae) is a high value medicinal herb which is used in both Indian and Chinese traditional medicines for various purposes such as treatment of cancer, hypertension, neurasthenia, giddiness, arthritis, dysentery, inflammation, sepsis and reproductive disorders. This species is restricted to specific habitat types, such as shaded, cold, moist habitats. However, the rhizomes of this species which are collected from wild populations have been traded throughout the Himalayan region and recently emerged as a significant source of income among local people of Indian Himalayan region...
November 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29109519/network-pharmacology-based-validation-of-tams-cxcl-1-as-key-mediator-of-xiaopi-formula-preventing-breast-cancer-development-and-metastasis
#11
Neng Wang, Yifeng Zheng, Jiangyong Gu, Youli Cai, Shengqi Wang, Fengxue Zhang, Jianping Chen, Honglin Situ, Yi Lin, Zhiyu Wang
Network pharmacology has become a powerful means of understanding the mechanisms underlying the action of Chinese herbs in cancer treatment. This study aims to validate the preventive effects and molecular mechanisms of a clinical prescription XIAOPI formula against breast cancer. In vivo breast cancer xenograft data showed that XIAOPI delayed breast cancer development and efficiently inhibited lung metastasis, accompanied by prolonged survival benefits and decreased cancer stem cell subpopulations. However, similar phenomenon were not observed in a cell model...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100936/characteristics-of-chinese-herbal-medicine-usage-and-its-effect-on-survival-of-lung-cancer-patients-in-taiwan
#12
Te-Mao Li, Yang-Hao Yu, Fuu-Jen Tsai, Chi-Fung Cheng, Yang-Chang Wu, Tsung-Jung Ho, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: In Taiwan, lung cancer remains one of the deadliest cancers. Survival of lung cancer patients remains low, ranging from 6% to 18%. Studies have shown that Chinese herbal medicine (CHM) can be used to induce cell apoptosis and exhibit anti-inflammatory activities in cancer cells. AIM OF THE STUDY: This study aimed to investigate the frequencies and patterns of CHM treatment for lung cancer patients and the effect of CHM on their survival probability in Taiwan...
October 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29098029/synergistic-anti-proliferative-and-pro-apoptotic-activities-of-5f-and-cisplatin-in-human-non-small-cell-lung-cancer-nci-h23-cells
#13
Yuchan Li, Wende Li, Wusheng Deng, Yuhong Gan, Kefeng Wu, Jie Sun
Two-drug combination chemotherapy, often including cisplatin and one other drug, remains the standard of care for patients with advanced non-small cell lung cancer (NSCLC). To improve the treatment of late-stage NSCLC and decrease the toxicity of combination chemotherapy, the search for novel drugs remains vigorous. Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F), a bioactive compound isolated from the herb Pteris semipinnata L., has previously been shown to induce apoptosis and inhibit proliferation in various cancer cells...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29097252/nf-%C3%AE%C2%BAb-and-jnk-mediated-apoptosis-and-g0-g1-arrest-of-hela-cells-induced-by-rubiarbonol-g-an-arborinane-type-triterpenoid-from-rubia-yunnanensis
#14
Guang-Zhi Zeng, Zhe Wang, Li-Mei Zhao, Jun-Ting Fan, Ning-Hua Tan
ETHNOPHARMACOLOGICAL RELEVANCE: Rubia yunnanensis is a medicinal plant mainly grown in Yunnan province in Southwest China, and its root named "Xiaohongshen" has been used as a herb in Yunnan for the treatment of cancers. Three major types of chemical components, Rubiaceae-type cyclopeptides, quinones, and triterpenoids, were identified from R. yunnanensis, in which some of compounds including rubiarbonol G (RG), a unique arboriane-type triterpenoid, showed cytotoxicity on cancer cells...
October 30, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29093644/synergistic-anticancer-effect-of-combined-crocetin-and-cisplatin-on-kyse-150-cells-via-p53-p21-pathway
#15
Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo, Hua-Qiao Wang
Background: More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication. Crocetin is a natural carotenoid dicarboxylic acid isolated from the Chinese herb saffron. We recently reported on the anticancer effects of saffron. This study aimed to determine whether crocetin combined cisplatin has synergistic effect in KYSE-150 cells and explore the underlying mechanism...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29073620/activation-of-erk-and-mutual-regulation-of-stat3-and-sp1-contribute-to-inhibition-of-pdk1-expression-by-atractylenolide-1-in-human-lung-cancer-cells
#16
Qian Xiao, Fang Zheng, JingJing Wu, Qing Tang, Wei Wang, Swei Sunny Hann
BACKGROUND/AIMS: Atractylodes macrocephula Koidz is an important ingredient in traditional Chinese herbs. One major bioactive compound, atractylenolide-1 (ATL-1), was reported to have anti-inflammatory and anti-tumor activities. However, the underlying molecular mechanism associated to this has not been well elucidated. METHODS: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively...
October 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29070781/cordycepin-induces-apoptotic-cell-death-and-inhibits-cell-migration-in-renal-cell-carcinoma-via-regulation-of-microrna-21-and-pten-phosphatase
#17
Chao Yang, Linlin Zhao, Weitang Yuan, Jianguo Wen
Cordycepin is an active component extracted from Traditional Chinese medical herb Cordyceps militaris. Many reports demonstrated that cordycepin harbors antitumor activity in a broad spectrum of cancer types. In this study the actions and the underneath molecular mechanisms of cordycepin were investigated in renal cell carcinoma Caki-1 cell line. Results showed that cordycepin induced apoptotic cell death and inhibited cell migration in Caki-1 cells. Quantitative real-time PCR results and western blot analyses indicated cordycepin dose-dependently decreased microRNA-21 expression and Akt phosphorylation levels in Caki-1 cells, but increased PTEN phosphatase levels...
2017: Biomedical Research
https://www.readbyqxmd.com/read/29069290/potent-suppression-of-both-spontaneous-and-carcinogen-induced-colitis-associated-colorectal-cancer-in-mice-by-dietary-celastrol-supplementation
#18
Emily C Barker, Byung-Gyu Kim, Ji Hee Yoon, Gregory P Tochtrop, John J Letterio, Sung Hee Choi
Celastrol is an anti-inflammatory natural triterpenoid, isolated from the herb Tripterygium wilfordii or thunder god vine. Here we define mechanisms mediating anti-inflammatory activity of celastrol and demonstrate efficacy of a dietary celastrol supplement for chemoprevention of inflammation-driven carcinogenesis in mice. Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6, and IL-1β...
October 21, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#19
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29050275/alisol-b-23-acetate-induces-autophagic-dependent-apoptosis-in-human-colon-cancer-cells-via-ros-generation-and-jnk-activation
#20
Yueliang Zhao, Edmund T S Li, Mingfu Wang
Alisol B 23-acetate (AB23A), a natural triterpenoid from the rhizome of Alisma orientale, a Chinese medicinal herb, has multiple physiological activities including anticancer. However, its effect on human colon cancer and the underlying mechanism are not clear. Here, we reported for the first time that AB23A induced cell cycle G1 phase arrest and apoptotic cell death in colon cancer cells. Autophagy also occurred in AB23A-treated HCT116 cells as evidenced by the accumulation of microtubule-associated protein 1 light chain 3 form II (LC3-II) and degradation of SQSTM1/p62...
September 19, 2017: Oncotarget
keyword
keyword
56690
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"