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Cancer AND phytochemicals

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https://www.readbyqxmd.com/read/28222613/phytochemical-investigations-and-antiproliferative-secondary-metabolites-from-thymus-alternans-growing-in-slovakia
#1
Stefano Dall'Acqua, Gregorio Peron, Sara Ferrari, Valentina Gandin, Massimo Bramucci, Luana Quassinti, Pavol Mártonfi, Filippo Maggi
CONTEXT: Thymus alternans Klokov (Lamiaceae) is a neglected species of the genus Thymus (Sect. Serpyllum) endemic to Carpathian area, where it is used as a flavouring agent and for medicinal purposes. OBJECTIVE: The aim of the work was to identify antiproliferative constituents from the flowering aerial parts of this plant. MATERIALS AND METHODS: Thymus alternans extracts were analyzed by HPLC-MS(n) and subjected to extensive chromatographic separations...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28219678/nortriterpenoids-from-the-stems-and-leaves-of-schisandra-viridis
#2
Ye Liu, Tian Tian, Heng-Yi Yu, Ming Zhou, Han-Li Ruan
An extensive phytochemical study on the stems and leaves of Schisandra viridis A. C. Smith led to the isolation of two novel highly oxygenated schinortriterpenoids, pre-schisanartanin P (1) and wuweizidilactone Q (2), together with four known ones (3-6). Their structures with absolute configurations were established on the basis of comprehensive spectroscopic methods, including HRESIMS, 1D and 2D NMR analyses and ECD experiments. All isolates were evaluated for their in vitro cytotoxicities against HepG2, MCF-7 and HT-29 cancer cell lines, none of them showed significant activities...
February 17, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28217550/antidiabetic-and-anticancer-activities-of-mangifera-indica-cv-okrong-leaves
#3
Aunyachulee Ganogpichayagrai, Chanida Palanuvej, Nijsiri Ruangrungsi
Diabetes and cancer are a major global public health problem. Plant-derived agents with undesirable side-effects were required. This study aimed to evaluate antidiabetic and anticancer activities of the ethanolic leaf extract of Mangifera indica cv. Okrong and its active phytochemical compound, mangiferin. Antidiabetic activities against yeast α-glucosidase and rat intestinal α-glucosidase were determined using 1 mM of p-nitro phenyl-α-D-glucopyranoside as substrate. Inhibitory activity against porcine pancreatic α-amylase was performed using 1 mM of 2-chloro-4 nitrophenol-α-D-maltotroside-3 as substrate...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28216884/chemical-components-from-aloe-and-their-inhibition-of-indoleamine-2-3-dioxygenase
#4
Ya Nan Sun, Lin Ying Li, Wei Li, Jong Seong Kang, Inkyu Hwang, Young Ho Kim
BACKGROUND: In Korea, Aloe is routinely ingested as a traditional medicine or as a component of health beverages. OBJECTIVE: To research the inhibition of indoleamine 2, 3-dioxygenase (IDO) activities of components from Aloe. MATERIALS AND METHODS: the compounds were isolated by a combination of silica gel and YMC Rp-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-NMR, and MS). All of the isolated compounds were examined for their ability to inhibit IDO, which actively suppresses immune functions by catalyzing the rate limiting reaction in the conversion of tryptophan to kynurenine...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28215418/immunomodulatory-hemolytic-properties-and-cytotoxic-activity-potent-of-triterpenoid-saponins-from-cephalaria-balansae
#5
Hilal Top, Nazli Boke Sarikahya, Ayse Nalbantsoy, Suheyla Kirmizigul
Phytochemical investigations on n-butanol extract of Cephalaria balansae Raus. (Caprifoliaceae) led to the isolation of four previously undescribed triterpenoid saponins based on hederagenin type aglycone, namely, balansoides A-D, along with ten known compounds. Their structures were proposed based on 1D and 2D NMR spectroscopic data, HRESIMS analysis and chemical evidence as 3-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl hederagenin, 3-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl ester, 3-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-galactopyranosyl-(1 → 6)-β-D-glucopyranosyl ester and 3-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester...
February 16, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28210221/pharmacogenomic-characterization-and-isobologram-analysis-of-the-combination-of-ascorbic-acid-and-curcumin-two-main-metabolites-of-curcuma-longa-in-cancer-cells
#6
Edna Ooko, Onat Kadioglu, Henry J Greten, Thomas Efferth
Curcuma longa has long been used in China and India as anti-inflammatory agent to treat a wide variety of conditions and also as a spice for varied curry preparations. The chemoprofile of the Curcuma species exhibits the presence of varied phytochemicals with curcumin being present in all three species but AA only being shown in C. longa. This study explored the effect of a curcumin/AA combination on human cancer cell lines. The curcumin/AA combination was assessed by isobologram analysis using the Loewe additivity drug interaction model...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28202499/dietary-phytochemical-intake-from-foods-and-health-outcomes-a-systematic-review-protocol-and-preliminary-scoping
#7
Yasmine C Probst, Vivienne X Guan, Katherine Kent
INTRODUCTION: Dietary phytochemicals are found in plant-based foods such as fruits, vegetables and grains and may be categorised in a nested hierarchical manner with many hundred individual phytochemicals identified to date. To associate phytochemical intakes with positive health outcomes, a fundamental step is to accurately estimate the dietary phytochemical intake from foods reported. The purpose of this systematic review protocol is to describe the process to be undertaken to summarise the evidence for food-based dietary phytochemical intakes and health outcomes for adults...
February 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28198202/clinacanthus-nutans-a-review-on-ethnomedicinal-uses-chemical-constituents-and-pharmacological-properties
#8
Ihsan N Zulkipli, Rajan Rajabalaya, Adi Idris, Nurul Atiqah Sulaiman, Sheba R David
CONTEXT: Medicinal plants have attracted global attention for their hidden therapeutic potential. Clinacanthus nutans (Burm.f) Lindau (Acanthaceae) (CN) is endemic in Southeast Asia. CN contains phytochemicals common to medicinal plants, such as flavonoids. Traditionally, CN has been used for a broad range of human ailments including snake bites and cancer. OBJECTIVES: This article compiles the ethnomedicinal uses of CN and its phytochemistry, and thus provides a phytochemical library of CN...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28197628/resveratrol-induced-autophagy-and-apoptosis-in-cisplatin-resistant-human-oral-cancer-car-cells-a-key-role-of-ampk-and-akt-mtor-signaling
#9
Chao-Hsiang Chang, Chao-Ying Lee, Chi-Cheng Lu, Fuu-Jen Tsai, Yuan-Man Hsu, Je-Wei Tsao, Yu-Ning Juan, Hong-Yi Chiu, Jai-Sing Yang, Ching-Chiung Wang
Resveratrol is known to be an effective chemo-preventive phytochemical against multiple tumor cells. However, the increasing drug resistance avoids the cancer treatment in oral cavity cancer. In this study, we investigated the oral antitumor activity of resveratrol and its mechanism in cisplatin-resistant human oral cancer CAR cells. Our results demonstrated that resveratrol had an extremely low toxicity in normal oral cells and provoked autophagic cell death to form acidic vesicular organelles (AVOs) and autophagic vacuoles in CAR cells by acridine orange (AO) and monodansylcadaverine (MDC) staining...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28194226/cheminformatics-studies-to-analyze-the-therapeutic-potential-of-phytochemicals-from-rhazya-stricta
#10
Abdullah Y Obaid, Sreedhara Voleti, Roop Singh Bora, Nahid H Hajrah, Abdulkader M Shaikh Omer, Jamal S M Sabir, Kulvinder Singh Saini
Rhazya stricta is a unique medicinal plant source for many indole alkaloids, non-alkaloids, flavonoids, triterpenes and other unknown molecules with tremendous potential for therapeutic applications against many diseases. In the present article, we generated computational data on predictive properties and activity across two key therapeutic areas of cancer and obesity, and corresponding cheminformatics studies were carried out to examine druggable properties of these alkaloids. Computed physiochemical properties of the 78 indole alkaloids from R...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28192882/ethyl-acetate-fraction-of-pteris-vittata-l-alleviates-2-acetylaminofluorene-induced-hepatic-alterations-in-male-wistar-rats
#11
Paramjeet Kaur, Manish Kumar, Amrit Pal Singh, Satwinderjeet Kaur
Pteris vittata L. commonly called 'Brake Fern' possesses some interesting medicinal properties but its chemopreventive potential largely remains unexplored. Therefore, this study was designed to explore the chemopreventive efficacy of P. vittata L. ethyl acetate fraction (PVEA) against 2-acetylaminofluorene (2-AAF) induced liver toxicity in Wistar rats. Antioxidant activity of PVEA was evaluated using various in vitro antioxidant assays. The protective effects of PVEA were evaluated against 2-acetylaminofluorene (2-AAF) induced hepatic damage in Wistar rats...
February 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28190473/eucalrobusone-c-suppresses-cell-proliferation-and-induces-ros-dependent-mitochondrial-apoptosis-via-the-p38-mapk-pathway-in-hepatocellular-carcinoma-cells
#12
Kai-Li Jian, Chao Zhang, Zhi-Chun Shang, Lei Yang, Ling-Yi Kong
BACKGROUND: Eucalyptus extracts have anti-cancer activity against various cancer cells. Formyl-phloroglucinol meroterpenoids (FPMs), which are typical secondary metabolites of the genera Eucalyptus, have many important pharmacological activities. PURPOSE: Eucalrobusone C (EC), a new bioactive phytochemical, was first isolated from the leaves of Eucalyptus robusta in our laboratory. EC is a FPM, and our previous research revealed that EC showed strongest cytotoxicity in three cancer models than other compounds isolated from the leaves of E...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28184934/emodin-induces-apoptosis-of-lung-cancer-cells-through-er-stress-and-the-trib3-nf-%C3%AE%C2%BAb-pathway
#13
Jin Su, Yan Yan, Jingkun Qu, Xuewen Xue, Zi Liu, Hui Cai
Emodin is a phytochemical with potent anticancer activities against various human malignant cancer types, including lung cancer; however, the molecular mechanisms underlying the effects of emodin remain unclear. In the present study, the A549 and H1299 human non-small lung cancer cell lines were treated with emodin and the induced molecular effects were investigated. Changes in cell viability were evaluated by MTT assay, Hoechst staining was used to indicate the apoptotic cells, and western blotting was utilized to assess endoplasmic reticulum (ER) stress and signaling changes...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28179225/influence-of-temperate-subtropical-and-tropical-fruit-consumption-on-risk-of-type-2-diabetes-in-an-asian-population
#14
Derrick Johnston Alperet, Lesley M Butler, Woon-Puay Koh, Jian-Min Yuan, Rob M van Dam
Background: Findings on the relation between fruit consumption and the risk of type 2 diabetes mellitus (T2DM) have been inconsistent.Objectives: We examined whether the consumption of total, temperate, subtropical, and tropical fruit is associated with T2DM risk and whether differences in the carbohydrate quality of fruit influence T2DM risk in Asians.Design: We included 45,411 participants in the Singapore Chinese Health Study who were 45-74 y old and had no diabetes, cancer, or cardiovascular disease at recruitment (1993-1998)...
February 8, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28178952/study-of-phytochemical-anti-microbial-anti-oxidant-and-anti-cancer-properties-of-allium-wallichii
#15
Jaya Bhandari, BushraTaj Muhammad, Pratiksha Thapa, Bhupal Govinda Shrestha
BACKGROUND: There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have investigated the anticancer potential of plant Allium wallichii, a plant native to Nepal and growing at elevations of 2300-4800 m. This is the first study of its kind for the plant mentioned. METHODS: The dried plant was extracted in aqueous ethanol. Phytochemical screening, anti-microbial assay, anti-oxidant assay, cytotoxicity assay and the flow-cytometric analysis were done for analyzing different phytochemicals present, anti-microbial activity, anti-oxidant activity and anti-cancer properties of Allium wallichii...
February 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28176652/mechanisms-for-inhibition-of-colon-cancer-cells-by-sulforaphane-through-epigenetic-modulation-of-microrna-21-and-human-telomerase-reverse-transcriptase-htert-down-regulation
#16
Samantha L Martin, Rishabh Kala, Trygve O Tollefsbol
Epigenetic modulations such as histone modifications are becoming increasingly valued for their ability to modify genes without altering the DNA sequence. Many bioactive compounds have been shown to alter genetic and epigenetic profiles in various forms of 6 cancers. Of the many dietary phytochemicals, sulforaphane (SFN), found in cruciferous vegetables such as kale, cabbage and broccoli sprouts, has been present as one of the most potent (histone deacetylase) HDAC inhibitors to date. Recently, it has been 9 identified that HDAC inhibitors may play a vital role in regulating microRNAs (miRNAs) in many human cancers...
February 5, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28174107/cytotoxic-clerodane-diterpenoids-from-croton-crassifolius
#17
Jin-Long Tian, Guo-Dong Yao, Yu-Xi Wang, Pin-Yi Gao, Di Wang, Ling-Zhi Li, Bin Lin, Xiao-Xiao Huang, Shao-Jiang Song
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and treatment options for HCC are limited. In addition, the discovery of new natural compounds with anti-hepatocarcinoma activity is attracting increasing attention. For this reason, phytochemical investigation of Croton crassifolius led to the isolation of 17 diterpenoids, including three new clerodane diterpenoids, named crassifolius A-C (1-3), along with 14 known ones (4-17). Their structures were established by 1D, 2D NMR, HR-ESI-MS, detailed calculated electronic circular dichroism (ECD) spectra and the assistance of quantum chemical predictions (QCP) of (13)C NMR chemical shifts...
January 20, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28169233/prophylactic-role-of-some-plants-and-phytochemicals-against-radio-genotoxicity-in-human-lymphocytes
#18
REVIEW
Mohsen Cheki, Ehsan Mihandoost, Alireza Shirazi, Aziz Mahmoudzadeh
Genotoxicity in lymphocytes of cancer patients undergoing radiotherapy can lead to lymphocytopenia. Lymphocytopenia induced by radiotherapy is one of the most unfavorable prognostic biological markers in cancer patients, since it has been accepted to be associated with poor prognosis in terms of both survival time and response to cancer therapy. Therefore, reduction in lymphocytopenia may increase treatment efficiency. Research endeavors with synthetic radioprotectors in the past have met with little success primarily due to toxicity-related problems...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28163117/promising-anticancer-activities-of-j-simplex-in-cellular-and-animal-models
#19
Litty Joseph, Jessil Mathew Aranjani, Sreedhara Ranganath Pai, K K Srinivasan
ETHNOPHARMACOLOGICAL RELEVANCE: Justicia simplex D. Don belonging to the family of Acanthaceae has been traditionally used for treatment of rheumatism, inflammation, bronchitis. The plant is traditionally considered as anti-cancer medicine and used by healers of Karnataka to treat various types of cancers (Corrêa and Alcântara, 2012). AIM OF THE STUDY: The present study is aimed at elucidating the cytotoxic activity of various extracts of Justicia simplex D. Don, isolation of active constituents and assessing the role in growth inhibition and angiogenesis both in vitro and in vivo...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28162105/molecular-insights-into-cancer-therapeutic-effects-of-the-dietary-medicinal-phytochemical-withaferin-a
#20
Chandra Sekhar Chirumamilla, Claudina Pérez-Novo, Xaveer Van Ostade, Wim Vanden Berghe
Despite the worldwide research efforts to combat cancer, it remains a leading cause of death. Although various specific kinase inhibitors already have been approved for clinical cancer treatment, occurrence of intrinsic or acquired resistance and intermittent response over longer periods limits long-term success of single kinase-targeted therapies. In this respect, there is a renewed interest in polypharmaceutical natural compounds, which simultaneously target various hyperactivated kinases involved in tumour-inflammation, angiogenesis, cell survival, proliferation, metastasis and angiogenesis...
February 6, 2017: Proceedings of the Nutrition Society
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