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Cancer AND phytochemicals

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https://www.readbyqxmd.com/read/28640972/understanding-adaptogenic-activity-specificity-of-the-pharmacological-action-of-adaptogens-and-other-phytochemicals
#1
REVIEW
Alexander Panossian
Adaptogens are stress-response modifiers that increase an organism's nonspecific resistance to stress by increasing its ability to adapt and survive. The classical reductionist model is insufficiently complex to explain the mechanistic aspects of the physiological notion of "adaptability" and the adaptogenic activity of adaptogens. Here, I demonstrate that (1) the mechanisms of action of adaptogens are impossible to rationally describe using the reductionist concept of pharmacology, whereas the network pharmacology approach is the most suitable method; and (2) the principles of systems biology and pharmacological networks appear to be more suitable for conceptualizing adaptogen function and are applicable to any phytochemical...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28635652/fucaceae-a-source-of-bioactive-phlorotannins
#2
REVIEW
Marcelo D Catarino, Artur M S Silva, Susana M Cardoso
Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28630399/dietary-mastic-oil-extracted-from-pistacia-lentiscus-var-chia-suppresses-tumor-growth-in-experimental-colon-cancer-models
#3
Katerina Spyridopoulou, Angeliki Tiptiri-Kourpeti, Evangeli Lampri, Eleni Fitsiou, Stavros Vasileiadis, Manolis Vamvakias, Haido Bardouki, Anna Goussia, Vasiliki Malamou-Mitsi, Mihalis I Panayiotidis, Alex Galanis, Aglaia Pappa, Katerina Chlichlia
Plant-derived bioactive compounds attract considerable interest as potential chemopreventive anticancer agents. We analyzed the volatile dietary phytochemicals (terpenes) present in mastic oil extracted from the resin of Pistacia lentiscus var. chia and comparatively investigated their effects on colon carcinoma proliferation, a) in vitro against colon cancer cell lines and b) in vivo on tumor growth in mice following oral administration. Mastic oil inhibited - more effectively than its major constituents- proliferation of colon cancer cells in vitro, attenuated migration and downregulated transcriptional expression of survivin (BIRC5a)...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629185/leptadenia-reticulata-retz-wight-arn-jivanti-botanical-agronomical-phytochemical-pharmacological-and-biotechnological-aspects
#4
REVIEW
Sudipta Kumar Mohanty, Mallappa Kumara Swamy, Uma Rani Sinniah, Maniyam Anuradha
Leptadenia reticulata (Retz.) Wight & Arn. (Apocynaceae), is a traditional medicinal plant species widely used to treat various ailments such as tuberculosis, hematopoiesis, emaciation, cough, dyspnea, fever, burning sensation, night blindness, cancer, and dysentery. In Ayurveda, it is known for its revitalizing, rejuvenating, and lactogenic properties. This plant is one of the major ingredients in many commercial herbal formulations, including Speman, Envirocare, Calshakti, Antisept, and Chyawanprash. The therapeutic potential of this herb is because of the presence of diverse bioactive compounds such as α-amyrin, β-amyrin, ferulic acid, luteolin, diosmetin, rutin, β-sitosterol, stigmasterol, hentricontanol, a triterpene alcohol simiarenol, apigenin, reticulin, deniculatin, and leptaculatin...
June 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28627607/inactivation-of-akt-erk-and-nf-%C3%AE%C2%BAb-by-genistein-derivative-7-difluoromethoxyl-5-4-di-n-octylygenistein-reduces-ovarian-carcinoma-oncogenicity
#5
Yingxia Ning, Meng Xu, Xiaocheng Cao, Xiangding Chen, Xin Luo
Cancer stem cells (CSCs) have central functions in cancer formation and development. Aberrant expression of AKT, ERK and NF-κB signaling pathways have been reported in several types of CSCs. Phytochemicals from dietary compounds possess anti-CSC properties, and have been characterized as promising therapeutic agents for the prevention and treatment of many types of cancers. We previously showed that the newly synthesized genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein (DFOG), can inhibit the self-renewal ability of ovarian cancer stem cells (OVCSLCs)...
June 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28627598/curcumin-exerts-its-tumor-suppressive-function-via-inhibition-of-nedd4-oncoprotein-in-glioma-cancer-cells
#6
Xue Wang, Jiaojiao Deng, Jinxia Yuan, Xin Tang, Yuelong Wang, Haifeng Chen, Yi Liu, Liangxue Zhou
Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers...
June 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28626743/phytochemical-screening-and-cytotoxic-evaluation-of-euphorbia-turcomanica-on-hela-and-ht-29-tumor-cell-lines
#7
Mehdi Aliomrani, Abbas Jafarian, Behzad Zolfaghari
BACKGROUND: Cancer is a term for a large group of different diseases, all involving uncontrolled cell growth. Many of Euphorbiaceae plants have been traditionally used for the treatment of ulcers, tumors, warts, and other diseases. In addition, in the last decade, there are studies showing cytotoxic effects of different species of Euphorbia on tumor cell lines. In this study, we attempted to determine if Euphorbia turcomanica possess any cytotoxic activity. MATERIALS AND METHODS: Solvents extracted the plant powder with various polarities by a maceration method, and qualitative phytochemical analyzes were carried out on them to identify the constituents...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28626741/isolation-and-identification-of-two-phenolic-compounds-from-a-moderately-cytotoxic-fraction-of-cousinia-verbascifolia-bunge
#8
Seyed Ebrahim Sajjadi, Mustafa Ghanadian, Mehrangiz Haghighi
BACKGROUND: Little information is available about chemical components of the Cousinia genus. A primary cytotoxicity screening on Cousinia verbascifolia showed moderate cytotoxic activity against OVCAR-3 ovarian and HT-29 colon cancer cells. Therefore, the aim of this study is a phytochemical investigation to identify the compounds responsible for this bioactivity. MATERIALS AND METHODS: Extraction was done through percolation and fractionations by reverse phase column chromatography and normal column chromatography...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28626426/potential-of-central-eastern-and-western-africa-medicinal-plants-for-cancer-therapy-spotlight-on-resistant-cells-and-molecular-targets
#9
REVIEW
Armelle T Mbaveng, Victor Kuete, Thomas Efferth
Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA) regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp), multi drug-resistance-related proteins (MRPs), breast cancer resistance protein (BCRP, ABCG2) as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1), human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28618011/the-healthy-effects-of-strawberry-bioactive-compounds-on-molecular-pathways-related-to-chronic-diseases
#10
REVIEW
Francesca Giampieri, Tamara Y Forbes-Hernandez, Massimiliano Gasparrini, Sadia Afrin, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, Jose L Quiles, Bruno Mezzetti, Maurizio Battino
It is generally accepted that a fruit and vegetable-enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined...
June 15, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28609132/antioxidant-and-anticancer-properties-of-berries
#11
Bincy Baby, Priya Antony, Ranjit Vijayan
The enduring relationship between dietary patterns and human health has led us to investigate the bioactive components present in fruits and vegetables for a very long time. Berries, notably the popular ones such as strawberry, raspberry, blueberry, blackberry and the Indian gooseberry, are among the best known dietary sources due to the presence of a wide range of bioactive nutritive components. Bioactive components in berries include phenolic compounds, flavonoids and tannins apart from vitamins, minerals, sugars and fibers...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28596028/furofuran-lignans-from-the-simpson-desert-species-eremophila-macdonnellii
#12
Yuen P Tan, Andrei I Savchenko, Natasa Broit, Glen M Boyle, Peter G Parsons, Craig M Williams
The Eremophila plant family, which occurs in the arid zones of Australia, have witnessed extensive investigation, mostly inspired by Aboriginal traditional medicine. A wide and varied biological and phytochemical profile has been reported for over 18 individual species of Australian Eremophila, although E. macdonnellii from the Simpson Desert has not yet been investigated. Isolation and elucidation of one new and six known furofuran lignans are reported. The new lignan, epimethoxypiperitol, displayed moderate anti-cancer activity against the breast cancer cell line (MCF-7)...
June 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28591690/a-review-on-phytoconstituents-and-biological-activities-of-cuscuta-species
#13
REVIEW
Ateeque Ahmad, Sudeep Tandon, Tran Dang Xuan, Zulfa Nooreen
The genus Cuscuta belonging to the Cuscutaceae family comprises of about 100-170 species spread around the world. Although several species have been studied for their phytochemical characterization and biological activities but still many species are yet unexplored till date. Cuscuta are parasitic plants generally of yellow, orange, red or rarely green color. The Cuscuta species were reported rich in flavonoid and glycosidic constituents along with alkaloids, fatty acids, fixed oil, minerals, essential oil and others phytomolecules also etc...
June 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28588600/date-palm-tree-phoenix-dactylifera-l-natural-products-and-therapeutic-options
#14
REVIEW
Reem A Al-Alawi, Jawhara H Al-Mashiqri, Jawaher S M Al-Nadabi, Badria I Al-Shihi, Younis Baqi
Many plants, including some of the commonly consumed herbs and spices in our daily food, can be safely and effectively used to prevent and/or treat some health concerns. For example, caffeine the active ingredient found in coffee beans (Coffea), shows biological activity in the treatment of the central nervous system (CNS) disorders, indole-3-carbinol, and 3,3'-diindolylmethane are both broccoli (Brassica oleracea) derived phytochemicals with potential anti-cancer activity, and resveratrol, isolated from grape (Vitis vinifera), is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28588481/medicinally-used-asarum-species-high-resolution-lc-ms-analysis-of-aristolochic-acid-analogs-and-in-vitro-toxicity-screening-in-hk-2-cells
#15
Johanna Michl, Olusheyi Bello, Geoffrey C Kite, Monique S J Simmonds, Michael Heinrich
Species of Asarum are used in traditional Chinese medicine and, similar to members of the genus Aristolochia, they contain aristolochic acid analogs (AAAs). These compounds are known for their nephrotoxic and carcinogenic effects. So far, the phytochemistry and nephrotoxicity of species of Asarum is not well studied. A high-resolution LC-MS-based metabolomic approach was used to study the phytochemical variation in medicinally used Asarum species. The cytotoxicity of the samples was assessed using human kidney (HK-2) cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28587155/dietary-intervention-by-phytochemicals-and-their-role-in-modulating-coding-and-non-coding-genes-in-cancer
#16
REVIEW
Liviuta Budisan, Diana Gulei, Oana Mihaela Zanoaga, Alexandra Iulia Irimie, Chira Sergiu, Cornelia Braicu, Claudia Diana Gherman, Ioana Berindan-Neagoe
Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer...
June 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28587101/therapeutic-applications-of-rose-hips-from-different-rosa-species
#17
REVIEW
Inés Mármol, Cristina Sánchez-de-Diego, Nerea Jiménez-Moreno, Carmen Ancín-Azpilicueta, María Jesús Rodríguez-Yoldi
Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer...
May 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28586002/effect-of-sorbus-commixta-on-the-invasion-and-migration-of-human-hepatocellular%C3%A2-carcinoma-hep3b%C3%A2-cells
#18
Hyerin Park, Hyunwook Park, Tae-Wook Chung, Hee-Jung Choi, Yeon-Seop Jung, Syng-Ook Lee, Ki-Tae Ha
Tumor metastasis is a main cause of cancer-related morbidity and mortality. Thus, a number of medicinal herbs and phytochemicals have been investigated as possible candidates for the inhibition of cancer metastasis. Sorbus commixta Hedl. (SC) is a traditional medicinal plant used in the treatment of inflammatory diseases, as it has antioxidant, anti-inflammatory, anti-atherosclerotic and anti-hepatotoxic activities. In this study, we demonstrate that the water extract of SC exerts inhibitory effect on the invasion and migration of hepatocellular carcinoma Hep3B cells...
June 2, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28585285/the-synergistic-potential-of-various-teas-herbs-and-therapeutic-drugs-in-health-improvement-a-review
#19
REVIEW
F Malongane, L J McGaw, F N Mudau
Tea is one of the most widely consumed non-alcoholic beverages in the world next to water. It is classified as Camellia sinensis and non-Camellia sinensis (herbal teas). The common bioactive compounds found mainly in green teas are flavan-3-ols (catechins) (also called flavanols), proanthocyanidins (tannins) and flavonols. Black tea contains theaflavins and thearubigins and white tea contains L-theanine and gamma-aminobutyric acid (GABA), while herbal teas contain diverse polyphenols. Phytochemicals in tea exhibit anti-microbial, anti-diabetic and anti-cancer activities that are perceived to be helpful in managing chronic diseases linked to lifestyle...
June 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28583139/cell-cycle-arrest-and-apoptosis-induction-by-methanolic-leaves-extracts-of-four-annonaceae-plants
#20
Kitti Pumiputavon, Tanawat Chaowasku, Chalermpong Saenjum, Maslin Osathanunkul, Boonsong Wungsintaweekul, Kriangkrai Chawansuntati, Jiraprapa Wipasa, Pathrapol Lithanatudom
BACKGROUND: Uvaria longipes (Craib) L.L.Zhou, Y.C.F.Su & R.M.K.Saunders, Artabotrys burmanicus A.DC, Marsypopetalum modestum (Pierre) B.Xue & R.M.K.Saunders and Dasymaschalon sp. have been used for traditional medicine to treat cancer-like symptoms in some ethnic groups of Thailand and Laos. METHODS: We evaluated the anti-cancer activity of these Annonaceae plants against several human cancer cell lines. The apoptosis induction was detected by Annexin/propidium iodide (PI) staining...
June 5, 2017: BMC Complementary and Alternative Medicine
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