keyword
MENU ▼
Read by QxMD icon Read
search

Cancer AND phytochemicals

keyword
https://www.readbyqxmd.com/read/29142346/conjugation-of-antibodies-with-radiogold-nanoparticles-as-an-effector-targeting-agents-in-radiobioconjugate-cancer-therapy-optimized-labeling-and-biodistribution-results
#1
Pankaj Garg, Daya Kishore Hazra
Purpose of the Study: Drug accessibility to the tumor cells is an important area of concern with an anticipation of increasing the efficacy of the drug to be delivered to a specific site. The biogenesis of gold nanoparticles using plant-mediated phytochemical extracts and their possible linkage to cancer antibodies with an aim at delivering the conjugate specifically to the tumor-associated antigen is the basic objective of the research. Materials and Methodology: Radiolabeling of antibodies with gold nanoparticles was carried out by a protocol, and the labeling extent of antibodies was compared with that of a radiogold solution to ordinary particulate size (AuNO-Ab)...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29141558/modulation-of-cancer-metabolism-by-phytochemicals-a-brief-overview
#2
Danina Muntean, Sturza Adrian, Ioana Pavel, Oana Duicu
Despite tremendous research efforts for effective therapies, cancer remains the plague of the century and its burden is expected to increase worldwide in the near future. Metabolic reprogramming is a firmly established hallmark of all cancers, regardless their cellular or tissue origin, being a prerequisite for both tumor growth and invasion. Functional dependence of tumors on glycolysis and glutaminolysis and the crucial contribution of mitochondria to the tumor bioenergetic versatility are well recognized features and established therapeutic targets...
November 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29141538/curcumin-a-natural-pan-hdac-inhibitor-in-cancer
#3
Sara Saffar Soflaei, Amir Abbas Momtazi, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
BACKGROUND: Histone deacetylases (HDACs) are a group of histone modification enzymes with pivotal role in disease pathogenesis especially in cancer development. Increased activity of certain types of HDACs and positive effects of HDAC inhibition has been shown in several types of cancers. Furthermore, few HDAC inhibitors have been approved by the FDA for cancer treatment, and this has generated interest in finding new HDAC inhibitors as potential anti-cancer agents. Curcumin, a natural polyphenol extracted from turmeric, is a safe and bioactive phytochemical with a wide range of molecular targets and pharmacological activities including promising anti-cancer properties...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29137206/ancient-food-habits-dictate-that-food-can-be-medicine-but-medicine-cannot-be-food
#4
Hit Kishore Goswami, Hitendra Kumar Ram
Background: Extensive surveys of several population settlements in different parts of India-covering plains, mountains, valleys, river banks and deeper areas of forests at different altitudes-between 1968 and 2016 demonstrated that the basic vital need of hunger is being fulfilled since antiquity by plants in the wild. Methods: Based on collections, consultations with local population personnel and literature searches, this paper presents many plants that are commonly used as food and focuses on their products, which are rich in alkaloids, polysaccharides, steroids, terpenoids, flavonoids, aminoacids, fatty acids and antibiotics etc...
November 13, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29129653/targeting-ncrnas-by-plant-secondary-metabolites-the-ncrnas-game-in-the-balance-towards-malignancy-inhibition
#5
REVIEW
Diana Gulei, Nikolay Mehterov, Seyed Mohammad Nabavi, Atanas Georgiev Atanasov, Ioana Berindan-Neagoe
The current trend of combining state of the art technologies with quondam treatments in order to overcome existing gaps in clinics determined an increased interest into polyphenols, common dietary phytochemicals, for the prevention and treatment of chronic diseases, especially cancer. The reemergence of polyphenols in the cancer field is sustained by transcriptomics technologies able to identify coding and non-coding genes and their related signaling pathways modulated by natural compounds. Identification of the structural correspondence between interacting molecules will allow the development of more targeted and informed therapeutic strategies for cancer management...
November 9, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29129015/melanoma-inhibition-by-anthocyanins-is-associated-with-the-reduction-of-oxidative-stress-biomarkers-and-changes-in-mitochondrial-membrane-potential
#6
Zoriţa Diaconeasa, Huseyin Ayvaz, Dumitriţa Ruginǎ, Loredana Leopold, Andreea Stǎnilǎ, Carmen Socaciu, Flaviu Tăbăran, Lavinia Luput, Diana Carla Mada, Adela Pintea, Andrew Jefferson
Anthocyanins are water soluble pigments which have been proved to exhibit health benefits. Several studies have investigated their effects on several types of cancer, but little attention has been given to melanoma. The phytochemical content of nine different berry samples was assessed by liquid chromatography followed by electrospray ionization mass spectrometry (LC-ESI(+)-MS). Twenty-six anthocyanins were identified, after a previous C18 Sep-pak clean-up procedure. Chokeberry and red grape anthocyanins rich extracts (C-ARE and RG-ARE) were selected to be tested on normal and melanoma cell lines, due to their different chemical pattern...
November 11, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29128800/beneficial-roles-of-honey-polyphenols-against-some-human-degenerative-diseases-a-review
#7
REVIEW
Md Sakib Hossen, Md Yousuf Ali, M H A Jahurul, Mohamed M Abdel-Daim, Siew Hua Gan, Md Ibrahim Khalil
Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health...
July 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29127008/direct-regulation-of-il-2-by-curcumin
#8
Jin-Gyo Oh, Da-Jeong Hwang, Tae-Hwe Heo
Interleukin-2 (IL-2) is a crucial growth factor for both regulatory and effector T cells. Thus, IL-2 plays a critical role in the stimulation and suppression of immune responses. Recently, anti-IL-2 antibodies (Abs) have been shown to possess strong IL-2 modulatory activities by affecting the interaction between IL-2 and IL-2 receptors. In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29121120/nature-is-the-best-source-of-anticancer-drugs-indexing-natural-products-for-their-anticancer-bioactivity
#9
Anwar Rayan, Jamal Raiyn, Mizied Falah
Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity...
2017: PloS One
https://www.readbyqxmd.com/read/29117727/crispoic-acid-a-new-compound-from-laelia-marginata-orchidaceae-and-biological-evaluations-against-parasites-human-cancer-cell-lines-and-zika-virus
#10
Andrezza C Belloto, Gredson K Souza, Paula C Perin, Ivania T A Schuquel, Silvana M O Santin, Lucas U R Chiavelli, Francielle P Garcia, Vanessa Kaplum, Jean H S Rodrigues, Débora B Scariot, Rodrigo Delvecchio, Erik Machado-Ferreira, Renato Santana Aguiar, Carlos A G Soares, Celso V Nakamura, Armando M Pomini
The phytochemical study of Laelia marginata (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid (1), together with six other known compounds (2-7). The new natural product was identified as a dimer of eucomic acid and was structurally characterised based upon 1D and 2D NMR and HRMS data. Biological assays with plant crude extract, fractions and isolated compounds were performed against two human cancer cell lines (Hela and Siha), and the tropical parasites Trypanosoma cruzi and Leishmania (Leishmania) amazonensis...
November 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29113871/oxidative-stress-and-dietary-phytochemicals-role-in-cancer-chemoprevention-and-treatment
#11
Shireen Chikara, Lokesh Dalasanur Nagaprashantha, Jyotsana Singhal, David Horne, Sanjay Awasthi, Sharad S Singhal
Several epidemiological observations have shown an inverse relation between consumption of plant-based foods, rich in phytochemicals, and incidence of cancer. Phytochemicals, secondary plant metabolites, via their antioxidant property play a key role in cancer chemoprevention by suppressing oxidative stress-induced DNA damage. In addition, they modulate several oxidative stress-mediated signaling pathways through their anti-oxidant effects, and ultimately protect cells from undergoing molecular changes that trigger carcinogenesis...
November 4, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29110298/long-term-genoprotection-effect-of-sechium-edule-fruit-extract-against-uva-irradiation-in-keratinocytes
#12
Elodie Metral, Walid Rachidi, Odile Damour, Frédéric Demarne, Nicolas Bechetoille
Photoprotection is essential to prevent the long-term deleterious effects of ultraviolet (UV), including skin cancer and photoaging. So far, there has been an increase in the use of natural bioactive phytochemicals for the development of more effective skin photoprotective agents. However, the molecular mechanisms underlying the photochemoprotection activity of such compounds remain largely unknown. The objective of this study was to investigate the effects of a Sechium edule fruit extract (SEE) in terms of photoprotection against UVA in primary human keratinocytes...
November 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29109723/inhibition-of-pro-inflammatory-and-anti-apoptotic-biomarkers-during-experimental-oral-cancer-chemoprevention-by-dietary-black-raspberries
#13
Steve Oghumu, Bruce C Casto, Jennifer Ahn-Jarvis, Logan C Weghorst, Jim Maloney, Paul Geuy, Kyle Z Horvath, Claire E Bollinger, Blake M Warner, Kurt F Summersgill, Christopher M Weghorst, Thomas J Knobloch
Oral cancer continues to be a significant public health problem worldwide. Recently conducted clinical trials demonstrate the ability of black raspberries (BRBs) to modulate biomarkers of molecular efficacy that supports a chemopreventive strategy against oral cancer. However, it is essential that a preclinical animal model of black raspberry (BRB) chemoprevention which recapitulates human oral carcinogenesis be developed, so that we can validate biomarkers and evaluate potential mechanisms of action. We therefore established the ability of BRBs to inhibit oral lesion formation in a carcinogen-induced rat oral cancer model and examined potential mechanisms...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29109061/extraction-fractionation-and-re-fractionation-of-artemisia-nilagirica-for-anticancer-activity-and-hplc-esi-qtof-ms-ms-determination
#14
Neha Sahu, Sanjeev Meena, Vijaya Shukla, Priyank Chaturvedi, Brijesh Kumar, Dipak Datta, K R Arya
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants used in traditional medicines are affordable, easily accessible, safer, less toxic and considered as a rich or efficient source of bioactive molecules for modern therapeutics. Artemisia nilagirica (AR) has a long history of use in Indian traditional medicine to combat a wide variety of diseases including cancer. AIM OF THE STUDY: Considering the vast potential of traditional healing plants to deliver safer, less toxic and efficient chemotherapeutics, we have examined anticancer activity of ethanolic extract, bioactive fractions and sub-fractions of AR against different human cancer cell lines along with their phytochemical analysis to understand the insights of novel anticancer activities for further preclinical studies...
November 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29101800/pharmacotherapeutic-potential-of-phytochemicals-implications-in-cancer-chemoprevention-and-future-perspectives
#15
REVIEW
Varinder Kaur, Manish Kumar, Ajay Kumar, Kamaldeep Kaur, Varinderpal Singh Dhillon, Satwinderjeet Kaur
Cancer is a leading cause of disease burden throughout the world. Many cancers develop as a result of exposure to both lifestyle and environmental factors that are potentially modifiable. In the last few years, much of the scientific attention has drawn to the discovery of new and effective chemopreventive agents from natural sources. A multitude of phytoconstituents have been explored for their potential to prevent the occurrence of carcinogenesis both in vitro and in vivo by means of diverse cellular and molecular approaches...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29091872/the-relevance-of-folkloric-usage-of-plant-galls-as-medicines-finding-the-scientific-rationale
#16
REVIEW
Seema Patel, Abdur Rauf, Haroon Khan
Galls, the abnormal growths in plants, induced by virus, bacteria, fungi, nematodes, arthropods, or even other plants, are akin to cancers in fauna. The galls which occur in a myriad of forms are phytochemically-distinct from the normal plant tissues, for these are the sites of tug-of-war, just like the granuloma in animals. To counter the stressors, in the form of the effector proteins of the invaders, the host plants elaborate a large repertoire of metabolites, which they normally will not produce. Perturbation of the jasmonic acid pathway, and the overexpression of auxin, and cytokinin, promote the tissue proliferation and the resultant galls...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080611/annona-muricata-is-the-natural-therapy-to-most-disease-conditions-including-cancer-growing-in-our-backyard-a-systematic-review-of-its-research-history-and-future-prospects
#17
REVIEW
Yahaya Gavamukulya, Fred Wamunyokoli, Hany A El-Shemy
Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many medicinal uses. This review focuses on the research history of its traditional uses, phytochemicals, pharmacological activities, toxicological aspects of the extracts and isolated compounds, as well as the in vitro propagation studies with the objective of stimulating further studies on this plant for human consumption and treatment. A. muricata extracts have been identified in tropical regions to traditionally treat diverse conditions ranging from fever to diabetes and cancer...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29079220/himatanthus-drasticus-apocynaceae-latex-reduces-oxidative-stress-and-modulates-cd4-cd8-foxp3-and-hsp-60-expressions-in-sarcoma-180-bearing-mice
#18
Glauco Jonas Lemos Santos, Emanuele Silva Oliveira, Ana Débora Nunes Pinheiro, Patricia Marçal da Costa, José Claudio Carneiro de Freitas, Francisco Glauco de Araújo Santos, Fernanda Maria Machado Maia, Selene Maia de Morais, Diana Célia Sousa Nunes-Pinheiro
ETHNOPHARMACOLOGICAL RELEVANCE: In Brazil, the latex of Himatanthus drasticus is used to treat inflammation, wound healing and cancer. The present study evaluated the antitumoral potential of H. drasticus latex (HdCL) in Sarcoma 180-bearing mice (S180). MATERIALS, METHODS: HdCL was obtained in Crato-CE, Brazil. Qualitative phytochemicals assays, nuclear magnetic resonance (NMR) and microbiological analyzes were performed. Swiss mice were divided into six groups, according to tumor forms: 1) ascitic model, GI (Control; 0...
October 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29075150/avenanthramide-c-reduces-the-viability-of-mda-mb-231-breast-cancer-cells-through-an-apoptotic-mechanism
#19
Jordan Hastings, Jason Kenealey
BACKGROUND: Avenanthramides (AVN) are a relatively unstudied family of phytochemicals that could be novel chemotherapeutics. These compounds, found in oats, are non-toxic to healthy cells and have been shown to reduce viability of human colon and liver cancers in vitro. However, these studies do not elucidate a molecular mechanism for individual AVN. In this study we aim to see the effects of AVN on MDA-MB-231 breast cancer cells. METHODS: An MTT assay was used to determine cell viability...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29071011/cancer-chemopreventive-potential-of-procyanidin
#20
REVIEW
Yongkyu Lee
Chemoprevention entails the use of synthetic agents or naturally occurring dietary phytochemicals to prevent cancer development and progression. One promising chemopreventive agent, procyanidin, is a naturally occurring polyphenol that exhibits beneficial health effects including anti-inflammatory, antiproliferative, and antitumor activities. Currently, many preclinical reports suggest procyanidin as a promising lead compound for cancer prevention and treatment. As a potential anticancer agent, procyanidin has been shown to inhibit the proliferation of various cancer cells in "in vitro and in vivo"...
October 2017: Toxicological Research
keyword
keyword
56689
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"