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https://www.readbyqxmd.com/read/29244254/effect-of-deconditioning-on-cortical-and-cancellous-bone-growth-in-the-exercise-trained-young-rats
#1
Jun Iwamoto, James K Yeh, John F Aloia
No abstract text is available yet for this article.
December 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29244083/nucleomethylin-deficiency-impairs-embryonic-erythropoiesis
#2
Shohei Murakami, Takuma Suzuki, Wataru Yokoyama, Satoko Yagi, Keita Matsumura, Yuka Nakajima, Hideo Harigae, Akiyoshi Fukamizu, Hozumi Motohashi
Nucleomethylin (NML) has been shown to contribute to ribosome formation through regulating transcription and post-transcriptional modification of rRNA. Based on the observation that NML-/- mice are frequently embryonic lethal, we analyzed NML-/- embryos to clarify the role of NML in embryogenesis. We found that NML deficiency leads to lethality at the time point between E10.5 and E12.5. Most of E10.5 NML-/- embryos exhibited growth retardation and/or malformation with marked impairment of erythropoiesis. Consistent with a previous study, the m1A in 28S rRNA was dramatically reduced in NML-/- fetal liver cells...
December 13, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29243443/-effect-of-clomiphene-citrate-and-dingkun-dan-on-ovulation-induction-and-clinical-pregnancy-of-polycystic-ovary-syndrome
#3
Lan Chen, Yong Tan, Shu-Ping Chen
The evaluation is based on clomiphene citrate (CC)+gonadotropin (Gn), clinical study on CC and Dingkun Dan's treatment on ovulation induction and clinical pregnancy effect of PCOS, and to provide ideas and methods for traditional Chinese medicine assisted reproductive treatment. This study selected 60 PCOS infertility patients treated with ovulation induction in reproductive medicine clinic, Jiangsu Province Hospital of traditional Chinese medicine during 2015-10-01-2017-04-23. They were randomly divided into two groups: Group A (CC+Gn+HCG) and Group B (CC+Gn+Dingkun Dan)...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29243166/a-hospital-and-home-based-exercise-program-to-address-functional-decline-in-people-following-allogeneic-stem-cell-transplantation
#4
S Abo, D Ritchie, L Denehy, Y Panek-Hudson, L Irving, C L Granger
PURPOSE: The aims of this study are to investigate the feasibility of an exercise program commencing 60 days following allogeneic stem cell transplantation (alloSCT), to investigate changes in physical function and health-related quality of life (HRQoL) in patients from pre- to post-alloSCT and to explore changes in patient outcomes before and after the program. METHODS: This study is a single site, prospective case series including 43 adults undergoing alloSCT...
December 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29242617/diversity-of-trion-states-and-substrate-effects-in-the-optical-properties-of-an-mos2-monolayer
#5
Matthias Drüppel, Thorsten Deilmann, Peter Krüger, Michael Rohlfing
Almost all experiments and future applications of transition metal dichalcogenide monolayers rely on a substrate for mechanical stability, which can significantly modify the optical spectra of the monolayer. Doping from the substrate might lead to the domination of the spectra by trions. Here we show by ab initio many-body theory that the negative trion (A-) splits into three excitations, with both inter- and intra-valley character, while the positive counterpart (A+) consists of only one inter-valley excitation...
December 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29239156/do-patients-require-escorts-or-carers-for-discharge-following-day-surgery-and-office-based-anesthesia-both-sides-of-the-debate-explored
#6
Keira P Mason, Christopher M Burkle
Over the past few years, there has been a rapid rise in office-based procedures, out of hospital and day surgery procedures, particularly as an effort to combat the escalating costs of hospital- based services. Coincident with this burgeoning demand for office based anesthesia, is the accompanying increased risk of anesthesia and sedation-related complications. In the 1990's and 2000's, the risk of mortality was higher for anesthetics and sedations performed outside of the operating theater setting. Although guidelines exist for ambulatory and office based anesthesia, they are being continuously reviewed and reconsidered...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29238859/-influence-of-thermodisinfection-on-impaction-of-cancellous-bone-an%C3%A2-in-vitro-model-of-femoral-impaction-bone-grafting
#7
REVIEW
C Fölsch, A Jahnke, A Groß, G Martels, G A Krombach, M Rickert, M Kampschulte
BACKGROUND: The reconstruction of bony defects during endoprosthesis revision surgery using "impaction bone grafting" leads to the possibility of a longstanding osseous integration to achieve good clinical results. Native allogeneic cancellous bone is often used for the procedure. This study examines the influence of thermodisinfection on the impaction behaviour of cancellous bone of different geometries and on the cement distribution. METHODS: The cancellous bone was obtained from the femoral heads of 7‑month old pigs...
December 13, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29237443/nursing-faculty-academic-incivility-perceptions-of-nursing-students-and-faculty
#8
Joshua K Muliira, Jansi Natarajan, Jacoba van der Colff
BACKGROUND: Incivility in nursing education can adversely affect the academic environment, the learning outcomes, and safety. Nursing faculty (NF) and nursing students (NS) contribute to the academic incivility. Little is known about the extent of NF academic incivility in the Middle East region. This study aimed at exploring the perceptions and extent of NF academic incivility in an undergraduate nursing program of a public university in Oman. METHODS: A cross sectional survey was used to collect data from 155 undergraduate NS and 40 NF about faculty academic incivility...
December 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29236600/benefit-of-intraoperative-neurophysiological-monitoring-in-a-pediatric-patient-with-spinal-dysmorphism-split-cord-malformation-and-scoliosis
#9
Faisal R Jahangiri, Samir Al Sayegh, Moutasem Azzubi, Abdulrahman M Alrajhi, Monerah M Annaim, Shmoukh A Al Sharif, Tanweer Aziz, Sami Al Eissa
Intraoperative neurophysiological monitoring (IONM) consists of a group of neurodiagnostic techniques that assess the nervous system's functional integrity during surgical operations. A retrospective analysis of a pediatric female patient was conducted who underwent 12 operations for the correction of scoliosis, tethered cord, and split spinal cord wherein IONM played an important role. From age 3 to 6, she underwent six procedures including a release of the tethered cord, resection of the filum terminale, removal of a T11-T12 bony spur, release of L3 adhesions, repair of subcutaneous meningocele, and correction of scoliosis with a vertical expandable prosthetic titanium rod (VEPTR) technique without the use of IONM...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29236176/na18f-accumulates-on-the-compressive-side-of-peri-implant-bone-under-immediate-loading
#10
Miou Yamamoto, Toru Ogawa, Masayoshi Yokoyama, Yoshihito Funaki, Kenta Shobara, Aya Shibamoto, Juan Ramón Vanegas Sáenz, Keiichi Sasaki
This study aimed to examine the dynamic change in bone metabolism by immediate loading in several sites around implants using high-resolution Na18F-PET scan. Two titanium implants (Ø 1.2 mm) were inserted parallel to each other in the right tibiae of Wistar rats (n = 4). The left tibia was set as control side. One day after insertion, closed coil springs of 4.0 N were attached to the expose superior portions of the implants to apply a continuous mechanical stress. The rats with fluorine-18 (18F) ion (5 mCi/rat) intravenously injected were scanned by PET scanner at 4, 7, 14, 28 days after load application...
December 13, 2017: Odontology
https://www.readbyqxmd.com/read/29235721/the-ideal-ionic-liquid-salt-bridge-for-the-direct-determination-of-gibbs-energies-of-transfer-of-single-ions-part-ii-evaluation-of-the-role-of-ion-solvation-and-ion-mobilities
#11
Andreas Ermantraut, Valentin Radtke, Niklas Gebel, Daniel Himmel, Thorsten Koslowski, Ivo Leito, Ingo Krossing
An important intermediate goal to evaluate our concept for the assumption-free determination of single ion Gibbs transfer energies ΔtrG°(i, S1 > S2) is presented: We executed the crucial steps a) and b) of the methodology, described in Part I of this treatise, exemplarily for Ag+ and Cl- with S1 being water and S2 being acetonitrile. The experiments showed that virtually all parts of the liquid junction potentials (LJPs) at both ends of a salt bridge cancel, if the bridge electrolyte is an "ideal" ionic liquid - one with nearly identical diffusion of anion and cation...
December 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29235713/the-ideal-ionic-liquid-salt-bridge-for-the-direct-determination-of-gibbs-energies-of-transfer-of-single-ions-part-i-the-concept
#12
Valentin Radtke, Andreas Ermantraut, Daniel Himmel, Thorsten Koslowski, Ivo Leito, Ingo Krossing
We describe a procedure for the thermodynamically rigorous, experimental determination of the Gibbs Energy of Transfer of single ions between solvents. The method is based on potential difference measurements between two electrochemical half cells with different solvents connected by an ideal Ionic Liquid Salt Bridge (ILSB). We discuss the specific requirements for the IL with regard to the procedure, ensuring that the Liquid Junction Potentials (LJP) at both ends of the ILSB cancel largely. The remaining parts of the LJPs can be determined by separate emf measurements...
December 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29234678/follow-up-measurement-of-corrected-qt-interval-in-adult-patients-before-and-after-lung-transplantation
#13
Dirk Bandorski, Reinhard Hoeltgen, Nicole Becker, Winfried Padberg, Harilaos Bogossian, Christoph Wiedenroth, Matthias Arlt, Christian Hamm, Werner Seeger, Hossein Ardeschir Ghofrani, Matthias Hecker, Henning Gall, Konstantin Mayer
Background: Prolongation of the corrected QT (QTc) interval is well known for many drugs, some of which are an integral part of the therapeutic regimen after lung transplantation (LTX). Therefore, we investigated the QTc interval after LTX in the present study. Patients and Methods: The medical records of patients after LTX were studied for demographic data, indication of LTX, medication, and baseline and follow-up ECGs. The QT interval was corrected for the patient's heart rate using the different formulae of Bazett, Fridericia, Hodges, and Framingham...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29233683/caspase-mediated-cleavage-of-x-ray-repair-cross-complementing-group-4-promotes-apoptosis-by-enhancing-nuclear-translocation-of-caspase-activated-dnase
#14
Yumi Sunatani, Radhika Pankaj Kamdar, Mukesh Kumar Sharma, Tadashi Matsui, Ryo Sakasai, Mitsumasa Hashimoto, Yasuhito Ishigaki, Yoshihisa Matsumoto, Kuniyoshi Iwabuchi
X-ray repair cross-complementing group 4 (XRCC4), a repair protein for DNA double-strand breaks, is cleaved by caspases during apoptosis. In this study, we examined the role of XRCC4 in apoptosis. Cell lines, derived from XRCC4-deficient M10 mouse lymphoma cells and stably expressing wild-type XRCC4 or caspase-resistant XRCC4, were established and treated with staurosporine (STS) to induce apoptosis. In STS-induced apoptosis, expression of wild-type, but not caspase-resistant, XRCC4 in XRCC4-deficient cells enhanced oligonucleosomal DNA fragmentation and the appearance of TUNEL-positive cells by promoting nuclear translocation of caspase-activated DNase (CAD), a major nuclease for oligonucleosomal DNA fragmentation...
December 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29233582/influence-of-involuntary-cigarette-smoke-inhalation-on-osseointegration-a-systematic-review-and-meta-analysis-of-preclinical-studies
#15
REVIEW
F Javed, S V Kellesarian, T Abduljabbar, A T Abduljabbar, Z Akram, F Vohra, I Rahman, G E Romanos
There are no studies that have systematically reviewed the influence of involuntary cigarette smoke inhalation (ICSI) on the stability of implants. The aim of the present study was to perform a systematic review and meta-analysis of preclinical studies that assessed the influence of involuntary cigarette smoke inhalation ICSI on osseointegration. Indexed databases (PubMed, Google-Scholar, Scopus, EMBASE, and Web of Knowledge) were searched till September 2017. Titles and abstracts of studies identified using the above-described protocol were independently screened by 2 authors...
December 9, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29233237/medical-implications-of-space-radiation-exposure-due-to-low-altitude-polar-orbits
#16
Jeffery C Chancellor, Serena M Auñon-Chancellor, John Charles
INTRODUCTION: Space radiation research has progressed rapidly in recent years, but there remain large uncertainties in predicting and extrapolating biological responses to humans. Exposure to cosmic radiation and solar particle events (SPEs) may pose a critical health risk to future spaceflight crews and can have a serious impact on all biomedical aspects of space exploration. The relatively minimal shielding of the cancelled 1960s Manned Orbiting Laboratory (MOL) program's space vehicle and the high inclination polar orbits would have left the crew susceptible to high exposures of cosmic radiation and high dose-rate SPEs that are mostly unpredictable in frequency and intensity...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29232726/-subtalare-screw-arthroereisis-for-the-treatment-of-symptomatic-flexible-pes-planovalgus
#17
Dariusch Arbab, Daniel Frank, Bertil Bouillon, Christian Lüring, Carsten Wingenfeld, Mona Abbara-Czardybon
Background The purpose of this study was to determine the functional outcomes and radiographic results of the talus-stop screw method as minimally invasive subtalar arthroereisis in pediatric and juvenile flexible flatfoot. Material and Methods We retrospectively evaluated 73 feet from 41 children using the talus stop-screw method, for the period between 2002 and 2011. The age at time of surgery ranged between nine and 14 years. The radiological assessment included measuring the calcaneal pitch, talar declination, talo-first metatarsal angle (Meary) and calcaneal-first metatarsal angle (Costa-Bartani) in the lateral view...
December 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29232073/medicare-program-cancellation-of-advancing-care-coordination-through-episode-payment-and-cardiac-rehabilitation-incentive-payment-models-changes-to-comprehensive-care-for-joint-replacement-payment-model-extreme-and-uncontrollable-circumstances-policy-for-the
#18
(no author information available yet)
This final rule cancels the Episode Payment Models (EPMs) and Cardiac Rehabilitation (CR) Incentive Payment Model and rescinds the regulations governing these models. It also implements certain revisions to the Comprehensive Care for Joint Replacement (CJR) model, including: Giving certain hospitals selected for participation in the CJR model a one-time option to choose whether to continue their participation in the model; technical refinements and clarifications for certain payment, reconciliation and quality provisions; and a change to increase the pool of eligible clinicians that qualify as affiliated practitioners under the Advanced Alternative Payment Model (Advanced APM) track...
December 1, 2017: Federal Register
https://www.readbyqxmd.com/read/29231748/relationship-between-patient-copayments-in-medicare-part-d-and-vaccination-claim-status-for-herpes-zoster-and-tetanus-diphtheria-acellular-pertussis
#19
Songkai Yan, Maral DerSarkissian, Rachel H Bhak, Patrick Lefebvre, Mei Sheng Duh, Girishanthy Krishnarajah
OBJECTIVE: To assess the relationship between copay amount and vaccination claim submission status for tetanus-diphtheria-acellular pertussis (Tdap) and herpes zoster (GSK study identifier: HO-14-14319). METHODS: Retrospective analyses were performed using vaccination administrative claims data in patients aged ≥65 years with ≥1 claim for Tdap or zoster vaccines between 2012-2014. To avoid confounding by other financial responsibility, analyses were conducted among patients in the copayment phase of insurance...
December 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29230533/regulation-of-type-i-collagen-expression-by-microrna-29-following-ionizing-radiation
#20
Hiroyuki Yano, Ryoji Hamanaka, Miki Nakamura-Ota, Juan Juan Zhang, Noritaka Matsuo, Hidekatsu Yoshioka
Radiation-induced fibrosis (RIF) is thought to involve the excessive accumulation of collagen and other extracellular matrix components; previously, we reported that ionizing radiation increased the type I collagen expression and that transforming growth factor (TGF)-β was involved in this increase through activating its downstream mediator, Smad3. A recent study found that microRNAs (miRNAs)-small, noncoding sequences approximately 20 nucleotides long-negatively regulate the gene expression posttranscriptionally, and it has been suggested that miRNAs play essential roles in cellular processes, including fibrosis...
December 11, 2017: Radiation and Environmental Biophysics
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