keyword
MENU ▼
Read by QxMD icon Read
search

Cancels

keyword
https://www.readbyqxmd.com/read/28634294/hidden-electrostatic-basis-of-dynamic-allostery-in-a-pdz-domain
#1
Amit Kumawat, Suman Chakrabarty
Allosteric effect implies ligand binding at one site leading to structural and/or dynamical changes at a distant site. PDZ domains are classic examples of dynamic allostery without conformational changes, where distal side-chain dynamics is modulated on ligand binding and the origin has been attributed to entropic effects. In this work, we unearth the energetic basis of the observed dynamic allostery in a PDZ3 domain protein using molecular dynamics simulations. We demonstrate that electrostatic interaction provides a highly sensitive yardstick to probe the allosteric modulation in contrast to the traditionally used structure-based parameters...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28633287/genetic-diseases-and-aneuploidies-can-be-detected-with-a-single-blastocyst-biopsy-a-successful-clinical-approach
#2
Maria Giulia Minasi, Francesco Fiorentino, Alessandra Ruberti, Anil Biricik, Elisabetta Cursio, Ettore Cotroneo, Maria Teresa Varricchio, Matteo Surdo, Francesca Spinella, Ermanno Greco
STUDY QUESTION: Can simultaneous detection of aneuploidies and genetic diseases or chromosomal aberrations in blastocysts reduce the chance of transferring embryos with low implantation potential, guaranteeing good clinical outcomes? SUMMARY ANSWER: The screening for chromosomal aneuploidies revealed that 50.6% of blastocysts diagnosed free of genetic disease or balanced, were aneuploid, therefore avoiding the transfer of blastocysts potentially resulting in implantation failures, miscarriages, or in some cases, in health affected live births...
June 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28630862/influence-of-deformation-and-stress-between-bone-and-implant-from-various-bite-forces-by-numerical-simulation-analysis
#3
Hsin-Chung Cheng, Boe-Yu Peng, May-Show Chen, Chiung-Fang Huang, Yi Lin, Yung-Kang Shen
Endosseous oral implant is applied for orthodontic anchorage in subjects with multiple tooth agenesis. Its effectiveness under orthodontic loading has been demonstrated clinically and experimentally. This study investigates the deformation and stress on the bone and implant for different bite forces by three-dimensional (3D) finite element (FE) methods. A numerical simulation of deformation and stress distributions around implants was used to estimate the survival life for implants. The model was applied to determine the pattern and distribution of deformations and stresses within the endosseous implant and on supporting tissues when the endosseous implant is used for orthodontic anchorage...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28627314/thicker-endometrial-linings-are-associated-with-better-ivf-outcomes-a-cohort-of-6331-women
#4
Emily C Holden, Laura E Dodge, Rita Sneeringer, Vasiliki A Moragianni, Alan S Penzias, Michele R Hacker
Our objective was to determine if a correlation exists between endometrial thickness measured on the day of ovulation trigger during an in vitro fertilization (IVF) cycle and pregnancy outcomes among non-cancelled cycles. We performed a retrospective cohort study looking at 6331 women undergoing their first, fresh autologous IVF cycle from 1 May 2004 to 31 December 2012 at Boston IVF (Waltham, MA). Our primary outcome was the risk ratio (RR) of live birth and positive β-hCG. We found that thicker endometrial linings were associated with positive β-hCG and live birth rates...
June 18, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28626050/admission-brain-cortical-volume-an-independent-determinant-of-poststroke-cognitive-vulnerability
#5
Sharmila Sagnier, Gwenaëlle Catheline, Bixente Dilharreguy, Fanny Munsch, Antoine Bigourdan, Mathilde Poli, Sabrina Debruxelles, Stéphane Olindo, Pauline Renou, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon
BACKGROUND AND PURPOSE: Several markers of poststroke cognitive impairment have been reported. The role of brain cortical volume remains uncertain. The aim of this study was to evaluate the influence of brain cortical volume on cognitive outcomes using a voxel-based morphometry approach in subjects without prestroke dementia. METHODS: Ischemic stroke patients were prospectively recruited 24 to 72 hours post-stroke (M0). Cognition was evaluated at M0, 3 months, and 1 year (M12) using the Montreal Cognitive Assessment, the Isaacs set test, and the Zazzo's cancellation task...
June 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28625485/motor-cortical-visuomotor-feedback-activity-is-initially-isolated-from-downstream-targets-in-output-null-neural-state-space-dimensions
#6
Sergey D Stavisky, Jonathan C Kao, Stephen I Ryu, Krishna V Shenoy
Neural circuits must transform new inputs into outputs without prematurely affecting downstream circuits while still maintaining other ongoing communication with these targets. We investigated how this isolation is achieved in the motor cortex when macaques received visual feedback signaling a movement perturbation. To overcome limitations in estimating the mapping from cortex to arm movements, we also conducted brain-machine interface (BMI) experiments where we could definitively identify neural firing patterns as output-null or output-potent...
June 6, 2017: Neuron
https://www.readbyqxmd.com/read/28625027/-a-case-of-bilateral-adrenal-incidentaloma-in-which-mtx-related-lymphoproliferative-disease-could-be-diagnosed-by-computed-tomography-guided-biopsy-and-mtx-administration-history
#7
Hiroaki Kitakaze, Makoto Matsushita, Koichi Okada, Noriko Minato, Naoki Mori, Toshiaki Yoshioka
The patient was a 76-year-old man. Because bilateral adrenal tumor (right adrenal gland 7 cm, left adrenal gland 1.5 cm) was detected in by computed tomography (CT) in methotrexate (MTX) administration for articular rheumatism from 2011, he was referred to this hospital in February, 2016. An endocrine examination, and imaging study did not lead to a definitive diagnosis and CT-guided lower needle biopsy was performed. The pathological diagnosis was diffuse large B cell lymphoma. Also, in situ hybridization revealed EBER-positive and the diagnosis of MTX-related lymphoproliferative disease (MTXLPD) was made in conjunction with the medical history...
May 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28623925/human-jugular-vein-collapse-in-the-upright-posture-implications-for-postural-intracranial-pressure-regulation
#8
Petter Holmlund, Elias Johansson, Sara Qvarlander, Anders Wåhlin, Khalid Ambarki, Lars-Owe D Koskinen, Jan Malm, Anders Eklund
BACKGROUND: Intracranial pressure (ICP) is directly related to cranial dural venous pressure (P dural ). In the upright posture, P dural is affected by the collapse of the internal jugular veins (IJVs) but this regulation of the venous pressure has not been fully understood. A potential biomechanical description of this regulation involves a transmission of surrounding atmospheric pressure to the internal venous pressure of the collapsed IJVs. This can be accomplished if hydrostatic effects are cancelled by the viscous losses in these collapsed veins, resulting in specific IJV cross-sectional areas that can be predicted from flow velocity and vessel inclination...
June 17, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28622936/acoustic-radiation-force-control-pulsating-spherical-carriers
#9
Majid Rajabi, Alireza Mojahed
The interaction between harmonic plane progressive acoustic beams and a pulsating spherical radiator is studied. The acoustic radiation force function exerted on the spherical body is derived as a function of the incident wave pressure and the monopole vibration characteristics (i.e., amplitude and phase) of the body. Two distinct strategies are presented in order to alter the radiation force effects (i.e., pushing and pulling states) by changing its magnitude and direction. In the first strategy, an incident wave field with known amplitude and phase is considered...
June 13, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28621284/comparison-of-platform-switched-and-sloping-shoulder-implants-on-stress-reduction-in-various-bone-densities-finite-element-analysis
#10
Joji Markose, S Suresh, Shruthi Eshwar, K Rekha, Vipin Jain, Supriya Manvi
INTRODUCTION: Comparison of platform switched (PS), sloping shoulder, and regular implants on stress reduction in various bone densities with finite element analysis. MATERIALS AND METHODS: A total of 12 three-dimensional finite element models were built to analyze the stress distribution model. Nobel Biocare 4.3 × 8 mm regular platform replace select implant with matching diameter easy abutment, Nobel Biocare 4.3 × 8 mm replace select implant PS with 3.5 mm diameter easy abutment, Bicon 4 × 8 mm implant with 4 mm diameter sloping shoulder abutments were created virtually in compact bone density using software...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28618802/non-negative-intensity-for-coupled-fluid-structure-interaction-problems-using-the-fast-multipole-method
#11
Daniel R Wilkes, Herwig Peters, Paul Croaker, Steffen Marburg, Alec J Duncan, Nicole Kessissoglou
The non-negative intensity (NNI) method is applied to large-scale coupled fluid-structure interaction (FSI) problems using the fast multipole boundary element method (FMBEM). The NNI provides a field on the radiating structure surface that consists of positive-only contributions to the radiated sound power, thus avoiding the near-field cancellation effects that otherwise occur with the sound intensity field. Thus far the NNI has been implemented with the boundary element method (BEM) for relatively small problem sizes to allow for the full BEM coefficient and inverse matrices to be explicitly constructed and stored...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28618618/critical-behavior-of-the-two-dimensional-ising-model-with-a-slit
#12
Xintian Wu
The two-dimensional Ising model with a slit is studied. The slit free energy is defined, in which the bulk term, edge terms, and corner terms other than that of the slit are canceled. The bond propagation algorithm is used to calculate the free energy, internal energy, and heat capacity numerically. At the critical point, the slit free energy has a logarithmic correction L^{-1}lnL, in addition to the correction lnL, where L is the typical length of the system. The fitted coefficients of these terms agree with the conformal field theory very well...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28618549/breakdown-of-the-stokes-einstein-relation-in-pure-lennard-jones-fluids-from-gas-to-liquid-via-supercritical-states
#13
Norikazu Ohtori, Shohei Miyamoto, Yoshiki Ishii
We have examined the conditions under which the breakdown of the Stokes-Einstein (SE) relation occurs in pure Lennard-Jones (LJ) fluids over a wide range of temperatures and packing fractions beyond the critical point. To this end, the temperature and packing-fraction dependence of the self-diffusion coefficient, D, and the shear viscosity, η_{sv}, were evaluated for Xe using molecular dynamics calculations with the Green-Kubo formula. The results showed good agreement with the experimental values. The breakdown was determined in light of the SE equation which we have recently derived for pure LJ liquids: Dη_{sv}=(k_{B}T/2π)(N/V)^{1/3}, where k_{B} is the Boltzmann constant, T is the temperature, and N is the particle number included in the system volume V...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28618433/crestal-sinus-augmentation-with-recombinant-human-bone-morphogenetic-protein-2-clinical-and-radiographic-outcomes-of-2-year-pilot-trial
#14
Ulrike Kuchler, Claudia M Rudelstorfer, Barbara Barth, Gabor Tepper, Dominika Lidinsky, Patrick Heimel, Georg Watzek, Reinhard Gruber
PURPOSE: Recombinant human bone morphogenetic protein 2 (rhBMP-2) together with an absorbable collagen carrier (ACS) was approved for augmentation of the maxillary sinus prior to implant placement. The original registration trial was based on a lateral window approach. Clinical outcomes of crestal sinus augmentation with rhBMP-2 have not been reported so far. MATERIALS AND METHODS: An uncontrolled pilot trial in which seven patients with a residual maxillary height below 5 mm were enrolled to receive crestal sinus augmentation with rhBMP-2/ACS was conducted...
June 14, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28617181/a-novel-surgical-approach-for-treating-distal-radial-extraarticular-malunion-oblique-osteotomy-with-buttress-plate-stabilization
#15
Chi-Chuan Wu
PURPOSE: Distal radial extraarticular malunions are not uncommon. However, requirements of surgical correction depend on multiple conditions. Traditionally, surgical techniques include closing or opening wedge osteotomies. Each has unique advantages and disadvantages. An oblique osteotomy was developed to simplify the revision surgery. METHODS: Forty-eight consecutive adult patients with 48 malunions were surgically treated. An oblique osteotomy of 45° vertical to the radial longitudinal axis was performed from medio-distally to latero-proximally...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28614236/utilization-of-ring-shaped-bone-allograft-for-surgical-treatment-of-adolescent-post-tubercular-kyphosis-a-retrospective-study
#16
Xiang Yin, Peng Liu, Yao-Yao Liu, Wei-Li Fan, Bai-Yi Liu, Jian-Hua Zhao
This study aimed to investigate the mid-term outcome of ring-shaped bone allografts in the surgical treatment of adolescent post-tubercular kyphosis secondary to spinal tuberculosis.The records of adolescent patients diagnosed with spinal tuberculosis who received treatment in our department between 2009 and 2013 were retrospectively reviewed. The anterior approach was used in cases of cervical kyphosis and the posterior approach was used in cases of thoracic and lumbar kyphosis. During the surgery, the ring-shaped bone was used as a structural bone graft associated with the cancellous bone filing in the center portion of the ring shape...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28610776/two-stage-late-reconstruction-with-a-fresh-large-osteochondral-shell-allograft-transplantation-flocsat-for-a-large-ostechondral-defect-in-a-non-union-after-a-lateral-tibia-plateau-fracture-2-year-follow-up
#17
C Krettek, J Clausen, M Omar, S Noack, C Neunaber
This is the description of a 58-year-old female patient presenting 8 months after a horse riding accident with significant pain and inability to walk independently. Imaging revealed a large osseous defect of the lateral tibia plateau which was not united posteriorly. The patient refused knee replacement and we developed a patient specific two-step procedure for her. Step 1: Filling of the defect with a large cortico-cancellous autograft from the posterior iliac crest; step 2: Transplantation of a fresh large osteochondral shell allograft (FLOCSAT)...
May 17, 2017: Injury
https://www.readbyqxmd.com/read/28609272/outcome-of-assisted-reproductive-technology-in-overweight-and-obese-women
#18
Antonio MacKenna, Juan Enrique Schwarze, Javier A Crosby, Fernando Zegers-Hochschild
OBJECTIVE: The main objective of this study was to assess the prevalence of overweight and obesity among patients undergoing assisted reproductive technology (ART) in Latin America and its consequences on treatment outcomes. METHODS: We used the Latin American Registry of ART to obtain women's age and body mass index (BMI), cancellation rate, number of oocytes retrieved and embryos transferred, clinical pregnancy, live birth and miscarriage rates from 107.313 patients undergoing autologous IVF and ICSI during four years; a multivariable analysis was performed to determine the effect of BMI on cancellation, oocytes retrieved, pregnancy, live birth and miscarriage, adjusting for age, number of embryos transferred and embryo developmental stage upon embryo transfer, when appropriate...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28609136/can-the-urolift-prostatic-implant-device-treat-the-symptoms-of-benign-prostatic-hypertrophy-avoid-sexual-dysfunction-and-reduce-hospital-turp-waiting-times-a-single-centre-single-surgeon-experience-and-review-of-the-literature
#19
Antonio D Bardoli, Will St J Taylor, Wasim Mahmalji
BPH associated with LUTS and sexual dysfunction is common. We performed UroLift on 11 patients, average age 71 years (range 56-90). IPSS improved by an average of 9 points post-procedure. Pre-operatively their post-void residuals were 306.3 ml (range 120-499 ml SD [120.6]) and their QMAX was 7 ml/s (range 4-14 SD [2.8] ml/s). Post-procedure the post-void residual decreased by 35.4% at 4 months (mean difference - 106.3 ml). QMAX improved by an average of 1.7 ml/s, which was not statistically significant...
June 13, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28608233/alleviation-by-gabab-receptors-of-neurotoxicity-mediated-by-mitochondrial-permeability-transition-pore-in-cultured-murine-cortical-neurons-exposed-to-n-methyl-d-aspartate
#20
Toshihiko Kinjo, Yoshino Ashida, Hiroshi Higashi, Satoshi Sugimura, Miho Washida, Hiroki Niihara, Kiyokazu Ogita, Yukio Yoneda, Nobuyuki Kuramoto
Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-D-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated whether activation of GABAB receptor (GABABR), which is linked to membrane G protein-coupled inwardly-rectifying K(+) ion channels (GIRKs), leads to protection of the NMDA-induced neurotoxicity in a manner relevant to mitochondrial membrane depolarization in cultured embryonic mouse cortical neurons...
June 12, 2017: Neurochemical Research
keyword
keyword
56687
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"