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https://www.readbyqxmd.com/read/29907082/paravertebral-dexmedetomidine-as-an-adjuvant-to-ropivacaine-protects-against-independent-lung-injury-during-one-lung-ventilation-a-preliminary-randomized-clinical-trial
#1
Wei Zhang, Shanfeng Zhang, Bing Li, Mingyang Sun, Jiaqiang Zhang
BACKGROUND: To investigate the effect of paravertebral dexmedetomidine as an adjuvant to ropivacaine on independent lung injury during one-lung ventilation. METHODS: In total, 120 patients who underwent elective radical resection of pulmonary carcinoma were randomly assigned to one of six groups (n = 20): normal saline (C group), ropivacaine (R group), intravenous dexmedetomidine (Div group), 0.5 μg/kg paravertebral dexmedetomidine as an adjuvant to ropivacaine (RD0...
June 15, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29884527/cushing-s-disease-with-pulmonary-cryptococcus-neoformans-infection-in-a-single-center-in-beijing-china-a-retrospective-study-and-literature-review
#2
Lin Lu, Yu Yue Zhao, Hong Bo Yang, Xin Lun Tian, Zuo Jun Xu, Zhao Lin Lu
BACKGROUND: Patients with Cushing's disease (CD) with hypercortisolism have an increased risk of opportunistic infection. However, most CD patients exposed to infections are diagnostic latency, leading to a poor prognosis. METHODS: Six patients in our hospital and an additional six patients in the literature were included in this study. Clinical information of CD patients with pulmonary Cryptococcus neoformans are reviewed. RESULTS: The average baseline total cortisol and ACTH in serum at 8 am of all the patients was 44...
June 5, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29850168/non-intubated-anaesthetic-technique-in-open-bilobectomy-in-a-patient-with-severely-impaired-lung-function
#3
Zsolt Szabó, Tamás Tanczos, Gábor Lebak, Zsolt Molnár, József Furák
General anaesthesia has been the most commonly used method for almost all types of thoracic surgery. Recently, there has been a growing interest in non-intubated anaesthetic techniques. The rationale being, to prevent complications related to general anaesthesia and positive pressure ventilation such as barotrauma or ventilation-perfusion mismatch. We present a case with severely impaired forced expiration volume (26%), carbon monoxide diffusing capacity (26%) and VO2 max (13.9 mL/kg/min). According to current guidelines, this patient was suitable to undergo one-lung ventilation only with high risk of morbidity and mortality...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29794869/the-clinical-significance-of-a-small-component-of-choriocarcinoma-in-testicular-mixed-germ-cell-tumor-mgct
#4
Oudai Hassan, Jonathan I Epstein
The clinical significance of limited choriocarcinoma in a malignant mixed germ cell tumor (MGCT) is unknown. Men with a MGCT with ≤5% choriocarcinoma at radical orchiectomy (RO) between 2000 and 2016 from our consult service were studied. Of 50 men in our cohort, we had clinical information for 30 men. Median follow-up was 41 months (1 to 168 mo). Median tumor size was 4.5 cm (1.1 to 8.0 cm). In total, 22/30 (73%) cases were pT1, 6/30(20%) cases were pT2, and 2/30 (7%) cases were pT3. In total, 4/30(13%) cases had lymph node metastases and 2/30 (7%) cases had distant metastases at the time of RO...
May 23, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29788985/establishment-of-lung-cancer-patient-derived-xenograft-models-and-primary-cell-lines-for-lung-cancer-study
#5
Yanan Jiang, Jimin Zhao, Yi Zhang, Ke Li, Tiepeng Li, Xinhuan Chen, Simin Zhao, Song Zhao, Kangdong Liu, Ziming Dong
BACKGROUND: The overall 5-year survival rate of lung cancer is about 15% even with therapeutic drugs like tyrosine kinase inhibitors. Ideal models are urgently needed for exploring mechanisms and finding new drugs. Patient-derived xenografts (PDX) models and primary cells are both used to screen therapeutic regimens for cancer. However, PDX models and primary cells from the same patient are difficult to establish. Their consistency to the original tumor tissue is not well studied. METHODS: 31 lung cancer patient tissues were procured to establish the lung cancer PDX models and primary cell lines...
May 22, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29776385/generation-of-ventilation-perfusion-ratio-map-in-surgical-patients-by-dual-energy-ct-after-xenon-inhalation-and-intravenous-contrast-media
#6
Kohei Aoki, Yotaro Izumi, Wataru Watanabe, Yuji Shimizu, Hisato Osada, Norinari Honda, Toshihide Itoh, Mitsuo Nakayama
BACKGROUND: While many studies have evaluated the change in lung volume before and after lung resection and correlated this with pulmonary function test results, there is very little evidence on the changes in ventilation perfusion ratio (V/Q) before versus after lung resection. In the present pilot study, we evaluated if V/Q mapping can be constructed using dual energy CT images. METHODS: Thirty-one lung cancer patients planned for pulmonary resection were included in this study...
May 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29756744/monitoring-the-oxygen-reserve-index-can-contribute-to-the-early-detection-of-deterioration-in-blood-oxygenation-during-one-lung-ventilation
#7
Wakana Koishi, Motoi Kumagai, Shohei Ogawa, Shuhei Hongo, Kenji Suzuki
BACKGROUND: Hypoxemia can occur during one-lung ventilation (OLV), but monitoring blood oxygenation using percutaneous oxygen saturation (SpO2) can be limited by detection latency, and SpO2 sometimes does not change during OLV. The Oxygen Reserve Index (ORiTM) is a novel index reported to detect impending desaturation before this is observed with SpO2 monitoring. This study assessed whether the ORi decreased earlier than SpO2 during OLV and evaluated its correlation with the partial pressure of arterial oxygen (PaO2) during OLV...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29756694/effects-of-inhalation-and-intravenous-anaesthesia-on-intraoperative-cardiopulmonary-function-and-postoperative-complications-in-patients-undergoing-thoracic-surgery-a-systematic-review-and-meta-analysis
#8
Qian-Yun Pang, Ran An, Hong-Liang Liu
INTRODUCTION: There is a high incidence of postoperative cardiopulmonary complications after thoracic surgery with one lung ventilation (OLV), the effect of general anaesthetics on intraoperative cardiopulmonary function and postoperative complications is still unclear. EVIDENCE ACQUISITION: We searched the Embase, Pubmed, Cochrane Library, Springer, Wiley, CNKI, VIP and Wanfang databases for randomized controlled trials (RCTs) in which inhalation anaesthesia and intravenous anaesthesia were compared; intraoperative cardiopulmonary function and postoperative complications were assessed in patients undergoing thoracic surgery with intraoperative one-lung ventilation (OLV)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29746696/detection-of-albumin-expression-by-rna-in-situ-hybridization-is-a-sensitive-and-specific-method-for-identification-of-hepatocellular-carcinomas-and-intrahepatic-cholangiocarcinomas
#9
Fan Lin, Jianhui Shi, Hanlin L Wang, Xiao-Jun Ma, Robert Monroe, Yuling Luo, Zongming Chen, Haiyan Liu
Objectives: Inconsistent data on detection of albumin expression by ribonucleic acid (RNA) in situ hybridization have been reported. We investigated the utility of RNAscope (Advanced Cell Diagnostics, Hayward, CA) in detection of albumin in hepatocellular carcinomas (HCCs), intrahepatic cholangiocarcinomas (ICCs), and carcinomas from various organs using manual and automated staining. Methods: RNAscope for albumin detection was performed on 482 cases on tissue microarray sections and on 22 cases of ICC, including 14 surgical resection and eight core biopsy specimens...
May 9, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29731641/combination-of-long-noncoding-rna-malat1-and-carcinoembryonic-antigen-for-the-diagnosis-of-malignant-pleural-effusion-caused-by-lung-cancer
#10
Wan-Wei Wang, Xi-Lei Zhou, Ying-Jian Song, Chang-Hua Yu, Wei-Guo Zhu, Yu-Suo Tong
Purpose: Long noncoding RNAs (lncRNAs) are present in body fluids, but their potential as tumor biomarkers has never been investigated in malignant pleural effusion (MPE) caused by lung cancer. The aim of this study was to assess the clinical significance of lncRNAs in pleural effusion, which could potentially serve as diagnostic and predictive markers for lung cancer-associated MPE (LC-MPE). Patients and methods: RNAs from pleural effusion were extracted in 217 cases of LC-MPE and 132 cases of benign pleural effusion (BPE)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29709437/the-effects-of-an-open-lung-approach-during-one-lung-ventilation-on-postoperative-pulmonary-complications-and-driving-pressure-a-descriptive-multicenter-national-study
#11
Javier Belda, Carlos Ferrando, Ignacio Garutti
OBJECTIVE: Thoracic surgical procedures are associated with an increased risk of postoperative pulmonary complications (PPCs), which seem to be related directly to intraoperative driving pressure. The authors conducted this study to describe the incidence of PPCs in patients in whom an individualized open-lung approach was applied during one-lung ventilation. DESIGN: This was a prospective, multicenter, national descriptive study. SETTING: Thoracic surgery patients undergoing one-lung ventilation...
March 27, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29707376/is-laryngeal-mask-airway-general-anesthesia-feasible-for-minimally-invasive-esophagectomy
#12
Rui-Xiang Zhang, Yin Li, Xian-Ben Liu, Xi-Hua Lu, Hai-Bo Sun, Zong-Fei Wang, Shi-Lei Liu, Yan Zheng, Xiao-Fei Liu, Xiu-Xia Wu
Minimally invasive esophagectomy (MIE) has been identified as an oncological method with lower mortality and morbidity. This procedure is usually performed under general anesthesia using double endotracheal tube intubation and one-lung ventilation for a good visualization like other video-assisted thoracoscopic surgery (VATS). However, it is difficult to differentiate weather the postoperative hoarseness is caused by intubation or by recurrent laryngeal nerve injury during operation, and some complications related to intubation also are the focus of thoracic surgeons...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707346/a-comparison-between-two-lung-ventilation-with-co-2-artificial-pneumothorax-and-one-lung-ventilation-during-thoracic-phase-of-minimally-invasive-esophagectomy
#13
Miao Lin, Yaxing Shen, Hao Wang, Yong Fang, Cheng Qian, Songtao Xu, Di Ge, Mingxiang Feng, Lijie Tan, Qun Wang
Background: To investigate the feasibility and safety of two lung ventilation with artificial pneumothorax in minimally invasive esophagectomy (MIE) through a comparison with conventional one lung ventilation. Methods: Eleven hundred and sixty-six patients with esophageal cancer, who underwent McKeown MIE in our center from February 2006 to December 2016, were studied retrospectively. Seven hundred and five patients who underwent one lung ventilation with double lumen endotracheal tube (DLET) were assigned to DLET group...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707341/short-term-one-lung-ventilation-does-not-influence-local-inflammatory-cytokine-response-after-lung-resection
#14
Silvia Fiorelli, Veronica Defraia, Fabiola Cipolla, Cecilia Menna, Mohsen Ibrahim, Claudio Andreetti, Maurizio Simmaco, Monica Rocco, Erino Angelo Rendina, Marina Borro, Domenico Massullo
Background: One-lung ventilation (OLV) is a ventilation procedure used for pulmonary resection which may results in lung injury. The aim of this study was to evaluate the local inflammatory cytokine response from the dependent lung after OLV and its correlation to VT. The secondary aim was to evaluate the clinical outcome of each patient. Methods: Twenty-eight consecutive patients were enrolled. Ventilation was delivered in volume-controlled mode with a VT based on predicted body weight (PBW)...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707298/effects-of-volume-controlled-ventilation-vs-pressure-controlled-ventilation-on-respiratory-function-and-inflammatory-factors-in-patients-undergoing-video-assisted-thoracoscopic-radical-resection-of-pulmonary-carcinoma
#15
Jing Tan, Zhenghuan Song, Qingming Bian, Pengyi Li, Lianbing Gu
Background: The best ventilation approach for patients undergoing video-assisted thoracic surgery (ATS) for pulmonary carcinoma remains undefined. This study aimed to assess hemodynamics, airway pressure, arterial blood gas, and inflammatory factors in patients undergoing VATS for pulmonary carcinoma under volume-controlled ventilation (VCV) or pressure-controlled ventilation (PCV). Methods: This was a prospective study of 60 patients with pulmonary carcinoma treated at a tertiary center in 2015-2016...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707296/sevoflurane-did-not-show-better-protective-effect-on-endothelial-glycocalyx-layer-compared-to-propofol-during-lung-resection-surgery-with-one-lung-ventilation
#16
Hye-Jin Kim, Eunsoo Kim, Seung-Hoon Baek, Hee Young Kim, Joo-Yun Kim, Juyeon Park, Eun-Ji Choi
Background: The endothelial glycocalyx layer (EGL) coats the alveolar capillary endothelium and plays important roles in pulmonary vascular protection, modulation, and hemostasis. Ischemia-reperfusion, which occurs during lung resection surgery with one lung ventilation (OLV), can damage the EGL. Sevoflurane is known for its protective effect against ischemia-reperfusion injury. Therefore, we hypothesized that lung resection surgery produces EGL damage and sevoflurane protects the EGL better than the intravenous anesthetic propofol...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29684371/repair-of-ductus-or-hemi-truncus-to-one-lung-and-major-aortopulmonary-collaterals-to-the-other-lung
#17
Richard D Mainwaring, Tatiana R Rosenblatt, William L Patrick, Michael Ma, Lynn Peng, Frank L Hanley
BACKGROUND: There are patients born with pulmonary atresia and a ductus arteriosus or hemi-truncus to one lung and major aortopulmonary collateral arteries (MAPCAs) to the contralateral lung. The purpose of this study was to review our surgical results for this relatively rare subset of patients. METHODS: This was a retrospective review of 35 patients with ductus/hemi-truncus in association with pulmonary atresia with ventricular septal defect and MAPCAs. Our surgical algorithm is bifurcated into two strategies: 1) patients with "favorable" MAPCAs are candidates for single stage complete repair, and 2) patients with "unfavorable" MAPCAs undergo a staged approach...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29659760/coxiella-burnetii-a-hidden-pathogen-in-interstitial-lung-disease
#18
Cléa Melenotte, Jalal-Jean Izaaryene, Carine Gomez, Marion Delord, Elsa Prudent, Hubert Lepidi, Oleg Mediannikov, Marion Lacoste, Felix Djossou, Alexandre Mania, Noelle Bernard, Eric Huchot, Jean-Louis Mège, Fabienne Brégeon, Didier Raoult
We report 7 patients with interstitial lung disease (ILD) on CT-scan reviewing. C. burnetii was diagnosed in situ in one lung biopsy performed. All patients had advanced interstitial lung fibrosis and persistent C. burnetii infection. Q fever may be a cofactor of ILD, especially in endemic areas.
April 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29649316/effect-of-one-lung-ventilation-on-end-tidal-carbon-dioxide-during-cardiopulmonary-resuscitation-in-a-pig-model-of-cardiac-arrest
#19
Dong Hyun Ryu, Yong Hun Jung, Kyung Woon Jeung, Byung Kook Lee, Young Won Jeong, Jong Geun Yun, Dong Hun Lee, Sung Min Lee, Tag Heo, Yong Il Min
Unrecognized endobronchial intubation frequently occurs after emergency intubation. However, no study has evaluated the effect of one-lung ventilation on end-tidal carbon dioxide (ETCO2) during cardiopulmonary resuscitation (CPR). We compared the hemodynamic parameters, blood gases, and ETCO2 during one-lung ventilation with those during conventional two-lung ventilation in a pig model of CPR, to determine the effect of the former on ETCO2. A randomized crossover study was conducted in 12 pigs intubated with double-lumen endobronchial tube to achieve lung separation...
2018: PloS One
https://www.readbyqxmd.com/read/29629895/oxidative-stress-and-dna-damage-due-to-one-lung-ventilation
#20
Samil Gunay, Abdullah Taskin, Irfan Eser, Saban Yalcin, Funda Yalcin
AIM: One-lung ventilation (OLV) is an anesthesia technique used to provide visualization in thoracoscopic lung surgeries and increase surgical site visibility during operation. In OLV, atelectasis occurs and blood from the lung participates in circulation without receiving oxygen. We designed a prospective study on patients we implemented surgery in order to research whether OLV leads to oxidative stress and DNA damage or not. METHODS: It was taken 5cc blood samples 4 times from these patients in the postoperative preparatory stage (T1), on the 60th minute after the start of OLV (T2), on the 60th minute after the termination of OLV (T3) and 24 hours after surgery (T4)...
2018: Annali Italiani di Chirurgia
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