Nicholas S Race, Katharine D Andrews, Elizabeth A Lungwitz, Sasha M Vega Alvarez, Timothy R Warner, Glen Acosta, Jiayue Cao, Kun-Han Lu, Zhongming Liu, Amy D Dietrich, Sreeparna Majumdar, Anantha Shekhar, William A Truitt, Riyi Shi
Traumatic brain injury (TBI) is associated with increased risk for mental health disorders, impacting post-injury quality of life and societal reintegration. TBI is also associated with deficits in psychosocial processing, defined as the cognitive integration of social and emotional behaviors, however little is known about how these deficits manifest and their contributions to post-TBI mental health. In this pre-clinical investigation using rats, a single mild blast TBI (mbTBI) induced impairment of psychosocial processing in the absence of confounding physical polytrauma, post-injury motor deficits, affective abnormalities, or deficits in non-social behavior...
June 4, 2021: Behavioural Brain Research