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https://www.readbyqxmd.com/read/29057458/support-needs-of-people-living-with-mycobacterium-ulcerans-buruli-ulcer-disease-in-a-ghana-rural-community-a-grounded-theory-study
#1
Alex Effah, Steven J Ersser, Ann Hemingway
INTRODUCTION/BACKGROUND: Mycobacterium ulcerans (also known as Buruli ulcer) disease is a rare skin disease which is prevalent in rural communities in the tropics mostly in Africa. Mortality rate is low, yet morbidity and consequent disabilities affect the quality of life of sufferers. AIMS: The aim of this paper is to use the grounded theory method to explore the support needs of people living with the consequences of Buruli ulcer in an endemic rural community in Ghana...
October 23, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29053605/flexible-sensors-for-pressure-therapy-effect-of-substrate-curvature-and-stiffness-on-sensor-performance
#2
Iryna Khodasevych, Suresh Parmar, Olga Troynikov
Flexible pressure sensors are increasingly being used in medical and non-medical applications, and particularly in innovative health monitoring. Their efficacy in medical applications such as compression therapy depends on the accuracy and repeatability of their output, which in turn depend on factors such as sensor type, shape, pressure range, and conformability of the sensor to the body surface. Numerous researchers have examined the effects of sensor type and shape, but little information is available on the effect of human body parameters such as support surfaces' curvature and the stiffness of soft tissues on pressure sensing performance...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29045487/the-psychosocial-impact-of-leg-ulcers-in-patients-with-sickle-cell-disease-i-don-t-want-them-to-know-my-little-secret
#3
Nkeiruka I Umeh, Brittany Ajegba, Ashley J Buscetta, Khadijah E Abdallah, Caterina P Minniti, Vence L Bonham
BACKGROUND: Sickle cell disease (SCD) impacts millions of individuals worldwide and more than 100,000 people in the United States. Leg ulcers are the most common cutaneous manifestation of SCD. The health status of individuals living with chronic leg ulcers is not only influenced by clinical manifestations such as pain duration and intensity, but also by psychosocial factors. Garnering insights into the psychosocial impact can provide a more holistic view of their influence on quality of life...
2017: PloS One
https://www.readbyqxmd.com/read/29037357/topical-timolol-promotes-healing-of-chronic-leg-ulcer
#4
Bindhiya Thomas, John Sajan Kurien, Toney Jose, Sansho Elavumkal Ulahannan, Sandeep Abraham Varghese
BACKGROUND: Chronic ulcers are a common problem, with chronic diabetic and venous ulcers forming a large proportion. This is the first case-control study to assess the effect of topical timolol on healing of chronic venous and chronic diabetic ulcers. METHODS: The study included 60 patients with chronic leg ulcers. The ulcers in the study group (n = 30) were treated with topical 0.5% timolol maleate solution along with antibiotics and dressings; those in the control group (n = 30) received only antibiotics and dressings...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29037356/three-dimensional-digital-imaging-is-as-accurate-and-reliable-to-measure-leg-ulcer-area-as-transparent-tracing-with-digital-planimetry
#5
Guillaume Chaby, Catherine Lok, Jean Philippe Thirion, Arnaud Lucien, Patricia Senet
OBJECTIVE: An accurate and reliable method for measuring venous leg ulcer (VLU) area is important in assessing treatment effects. The new three-dimensional (3D) LifeViz digital imaging system (QuantifiCare S.A., Valbonne, France) combines a compact, easy to use stereovision camera and image management software to provide 3D medical images. The aim of this prospective study was to investigate whether the 3D LifeViz digital imaging system could be considered a suitable alternative to manual transparent wound tracing for the measurement of VLU area and 4-week healing rates...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29037354/baseline-factors-affecting-closure-of-venous-leg-ulcers
#6
William A Marston, William J Ennis, John C Lantis, Robert S Kirsner, Robert D Galiano, Wolfgang Vanscheidt, Sabine A Eming, Marcin Malka, D Innes Cargill, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The objective of this study was to characterize factors associated with closure of venous leg ulcers (VLUs) in a pooled analysis of subjects from three randomized clinical trials. METHODS: Closure of VLUs after treatment with HP802-247, an allogeneic living cell therapy consisting of growth-arrested human keratinocytes and fibroblasts, vs standard therapy with compression bandaging was evaluated in three phase 3 clinical trials of similar design. Two trials enrolled subjects with VLUs ranging from 2 cm(2) to 12 cm(2) in area with 12-week treatment periods; the third trial enrolled subjects with VLUs between >12 cm(2) and ≤36 cm(2) with a 16-week treatment period...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29033819/an-unusual-presentation-of-pyoderma-gangrenosum-leading-to-systemic-inflammatory-response-syndrome
#7
Ali Didan, Alan Donnelly, Hock Chua
This is a report of an atypical presentation of pyoderma gangrenosum (PG) in a 26-year-old male who had a negative septic screen. The patient had a life-threatening presentation requiring an intensive care unit (ICU) admission for vasopressor support. It was thought that the likely cause of circulatory collapse was an overwhelming cytokine reaction or systemic inflammatory response syndrome (SIRS) secondary to extensive PG lesions rather than septic shock. The patient presented with multiple large ulcers, the largest being 4 cm in diameter on the central chest...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033815/cutaneous-nocardiosis-simulating-cutaneous-lymphatic-sporotrichosis
#8
Pedro Secchin, Beatriz Moritz Trope, Larissa Araujo Fernandes, Glória Barreiros, Marcia Ramos-E-Silva
Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29026859/molecular-identification-of-leishmania-species-in-a-re-emerged-focus-of-cutaneous-leishmaniasis-in-varamin-district-iran
#9
Mahmoodreza Behravan, Vahideh Moin-Vaziri, Ali Haghighi, Nourina Rahbarian, Niloofar Taghipour, Alireza Abadi, Homa Hajjaran
BACKGROUND: Cutaneous leishmaniasis (CL) is one of the most important neglected tropical diseases and a major public health challenge in Iran caused by Leishmania spp and transmitted by phlebotomine sand flies. The number of CL cases has shown an increasing pattern all over the country, including the district of Varamin, southeast of Tehran, Iran. This study aimed to identify the Leishmania spp isolated from CL patients using molecular methods in Varamin during 2012-2013. METHODS: Exudate materials collected from the swollen edge of the skin lesions of 44 parasitological positive CL patients by disposable lancet...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29024419/a-multicentre-randomised-controlled-trial-evaluating-the-efficacy-of-dehydrated-human-amnion-chorion-membrane-epifix%C3%A2-allograft-for-the-treatment-of-venous-leg-ulcers
#10
Christian Bianchi, Shawn Cazzell, Dean Vayser, Alexander M Reyzelman, Hasan Dosluoglu, Gregory Tovmassian
A randomised, controlled, multicentre clinical trial was conducted to evaluate the efficacy of dehydrated human amnion/chorion membrane (EpiFix) allograft as an adjunct to multilayer compression therapy for the treatment of non-healing full-thickness venous leg ulcers. We randomly assigned 109 subjects to receive EpiFix and multilayer compression (n = 52) or dressings and multilayer compression therapy alone (n = 57). Patients were recruited from 15 centres around the USA and were followed up for 16 weeks...
October 11, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28989569/clinical-profile-of-diabetes-at-diagnosis-among-children-and-adolescents-at-an-endocrine-clinic-in-ghana
#11
Emmanuel Ameyaw, Serwah B Asafo-Agyei, Sumithira Thavapalan, Angela C Middlehurst, Graham D Ogle
AIM: To determine the clinical features of diabetes in children and adolescents in Ghana. METHODS: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS: One hundred and six subjects presented with diabetes. Ninety (84.9%) were diagnosed by clinical features and family history as type 1, and 16 (15...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28989556/fibreglass-total-contact-casting-removable-cast-walkers-and-irremovable-cast-walkers-to-treat-diabetic-neuropathic-foot-ulcers-a-health-technology-assessment
#12
(no author information available yet)
BACKGROUND: Diabetic neuropathic foot ulcers are a risk factor for lower leg amputation. Many experts recommend offloading with fibreglass total contact casting, removable cast walkers, and irremovable cast walkers as a way to treat these ulcers. METHODS: We completed a health technology assessment, which included an evaluation of clinical benefits and harms, value for money, and patient preferences for offloading devices. We performed a systematic literature search on August 17, 2016, to identify randomized controlled trials that compared fibreglass total contact casting, removable cast walkers, and irremovable cast walkers with other treatments (offloading or non-offloading) in patients with diabetic neuropathic foot ulcers...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28987067/reconstruction-of-severe-atherosclerotic-and-obstructive-diabetic-feet-using-thoracodorsal-artery-perforator-flaps-with-long-vascular-pedicles
#13
Sang Wha Kim, Il Hoon Sung, Youn Hwan Kim
BACKGROUND: Foot ulcers in diabetic patients often require free flaps. A long vascular pedicle is mandatory so that more proximal vessels can be used as recipient vessels, especially when the flap is used to reconstruct distal foot defects. We evaluated the outcome of diabetic foot defect that were reconstructed using thoracodorsal artery perforator (TDAP) flaps with long vascular pedicles. PATIENTS AND METHODS: We reconstructed the foot defects of 22 diabetic patients...
October 7, 2017: Microsurgery
https://www.readbyqxmd.com/read/28985441/effects-and-associations-of-nutrition-in-patients-with-venous-leg-ulcers-a-systematic-review
#14
REVIEW
Georgina A Barber, Carolina D Weller, Simone J Gibson
AIMS: To identify the associations and effects of nutritional characteristics and interventions on ulcer outcomes in adult patients with venous leg ulcers. BACKGROUND: Venous leg ulcers are the most prevalent type of lower limb ulcer, however little evidence exists regarding the relationship between nutritional status and ulcer healing. DESIGN: A systematic search of English language articles was conducted using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions...
October 6, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28976834/managing-real-world-venous-leg-ulcers-with-fetal-bovine-acellular-dermal-matrix-a-single-centre-retrospective-study
#15
J A Paredes, S Bhagwandin, Polanco T, J C Lantis
OBJECTIVE: As compression treatment offers moderate improvement, especially to recurrent venous leg ulcers (VLUs), several alternative therapies using cellular based and/or tissue-derived products (CTPs) have emerged from bovine, porcine, and equine sources. Our aim was to look at the effect of a CTP in 'real-life' VLUs. METHODS: This study looked at complex patients with chronic, large wounds in a single-centre retrospective review. All patients were treated with fetal bovine acellular dermal matrix (FBADM) for VLUs at our outpatient urban wound care programme...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28976826/hydrosurgery-as-a-safe-and-efficient-debridement-method-in-a-clinical-wound-unit
#16
M Ferrer-Sola, H Sureda-Vidal, J Altimiras-Roset, E Fontsere-Candell, V Gonzalez-Martinez, J Espaulella-Panicot, V Falanga, M Otero-Viñas
OBJECTIVE: Hydrosurgical debridement allows removal of non-viable tissue, preserving healthy tissues. This study was designed to analyse whether hydrosurgery, used in a clinical wounds unit, is an effective and safe method that may reduce debridement time. METHODS: Patients' wounds had the following characteristics: wounds with devitalised tissue needing rapid debridement, wounds with cavities, or non-healing wounds. Hydrosurgical debridement uses a pressurised stream of saline (0...
October 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28976341/preliminary-results-of-a-topically-applied-bacteria-specific-antibiotic-gel-to-improve-wound-healing
#17
Caitlin S Zarick, Elizabeth A Benkert, Noah G Oliver, John S Steinberg, Karen K Evans, Christopher E Attinger, Zinnia M Rocha, Paul J Kim
INTRODUCTION: Advances in molecular diagnostic medicine have allowed for more rapid, accurate, and comprehensive methods for identifying microorganisms in a chronic wound, which led to the de- velopment and use of a tailored topical antibiotic gel aimed at treating this bioburden. OBJECTIVE: This is a retrospective chart review evalu- ating the authors' early experience with the use of bacteria-speci c antimicrobial gel therapy on chronic lower extremity wounds that have not responded to standard therapy...
September 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28973107/nonhealing-leg-ulcer-in-a-middle-aged-indian-man
#18
Keshavamurthy Vinay, Dipankar De, Uma N Saikia
No abstract text is available yet for this article.
September 27, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28972488/analysis-of-tissue-oxygenation-in-chronic-leg-ulcers-by-combination-of-a-multi-spectral-camera-and-a-hyper-spectral-probe
#19
P Zimmermann, A Scheibe, J Marotz, U Wollina
Objective evaluation of chronic wounds, such as leg ulcers, by the use of non-invasive techniques is of importance for diagnosis, monitoring treatment response, and probably leads to improved treatment strategies. We performed a feasibility study for the combined use of a multi-spectral camera and a hyper-spectral probe to evaluate chronic leg ulcers with a focus on tissue oxygenation. Sixty patients - 40 females and 20 males were enrolled in the study. The age range was 46 to 85 years for males (mean 65.8 years, median 73...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28964388/-health-related-quality-of-life-in-chronic-venous-disease-systematic-literature-review
#20
N Zenati, J L Bosson, S Blaise, P Carpentier
OBJECTIVE: Excepting life-threatening situations, improvement of health-related quality-of-life is the main therapeutic goal in chronic disease. The purpose of this review was to study the different ways of assessing Quality-of-Life (QoL) in patients with chronic venous disease (CVD) (CEAP classes C3 to C6). METHODS: A literature search was conducted with three databases: MEDLINE, WEB OF SCIENCE and COCHRANE LIBRARY in order to identify articles with the PRISMA reporting guidelines...
October 2017: J Med Vasc
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