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https://www.readbyqxmd.com/read/29222650/taxane-platinum-and-5-fu-prior-to-chemoradiotherapy-benefits-patients-with-stage-iv-neck-node-positive-head-and-neck-cancer-and-a-good-performance-status
#1
Natalie M Lowe, Jonathan M Bernstein, Kathleen Mais, Kate Garcez, Lip W Lee, Andrew Sykes, David J Thomson, Jarrod J Homer, Catharine M West, Nicholas J Slevin
PURPOSE: The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects and which patients benefit most. METHODS: A single-centre audit identified 132 HNSCC patients with stage IVa/b neck node-positive disease, prescribed TPF followed by CRT...
December 8, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29221778/long-term-treatment-with-dopamine-d3-receptor-agonists-induces-a-behavioral-switch-that-can-be-rescued-by-blocking-the-dopamine-d1-receptor
#2
Mai-Lynne Dinkins, Perrine Lallemand, Stefan Clemens
Restless legs syndrome (RLS) is commonly treated with the dopamine agonists pramipexole, and rotigotine, which target the inhibitory dopamine receptor subtype D3R. While initially highly effective, these compounds lose their efficacy in treating RLS over time, and long-term therapy regularly leads to a worsening of the symptoms (augmentation). This dopamine agonist-induced augmentation has become a prime concern in the treatment of RLS, and while alternate therapies are being proposed, the mechanisms leading to augmentation remain opaque...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29220772/column-integrated-aerosol-optical-properties-of-coarse-and-fine-mode-particles-over-the-pearl-river-delta-region-in-china
#3
B Mai, X Deng, X Xia, H Che, J Guo, X Liu, J Zhu, C Ling
The sun-photometer data from 2011 to 2013 at Panyu site (Panyu) and from 2007 to 2013 at Dongguan site (Dg) in the Pearl River Delta region, were used for the retrieving of the aerosol optical depth (AOD), single scattering albedo (SSA), Ångström exponent (AE) and volume size distribution of coarse- and fine-mode particles. The coarse-mode particles presented low AOD (ranging from 0.05±0.03 to 0.08±0.05) but a strong absorption property (SSA ranged from 0.70±0.03 to 0.90±0.02) for the wavelengths between 440 and 1020nm...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29218508/use-of-huh6-and-other-human-derived-hepatoma-lines-for-the-detection-of-genotoxins-a-new-hope-for-laboratory-animals
#4
Monika Waldherr, Miroslav Mišík, Franziska Ferk, Jana Tomc, Bojana Žegura, Metka Filipič, Wolfgang Mikulits, Sören Mai, Oskar Haas, Wolfgang W Huber, Elisabeth Haslinger, Siegfried Knasmüller
Cell lines which are currently used in genotoxicity tests lack enzymes which activate/detoxify mutagens. Therefore, rodent-derived liver preparations are used which reflect their metabolism in humans only partly; as a consequence misleading results are often obtained. Previous findings suggest that certain liver cell lines express phase I/II enzymes and detect promutagens without activation; however, their use is hampered by different shortcomings. The aim of this study was the identification of a suitable cell line...
December 7, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29218337/synthesis-and-photoelectrocatalytic-activity-of-in2o3-hollow-microspheres-via-a-bio-template-route-using-yeast-templates
#5
Duo Pan, Shengsong Ge, Xiyu Zhang, Xianmin Mai, Shengyao Li, Zhanhu Guo
Indium oxide (In2O3) hollow microspheres were prepared using yeast as a bio-template with the aid of a precipitation method. The yeast provided a solid frame for the deposition of In(OH)3 to form the precursor. The resulting In2O3 hollow microspheres were obtained by calcining the precursor at 650 °C. The samples were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption isotherms and UV-Vis diffuse reflectance spectroscopy...
December 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29217782/rational-management-approach-to-pure-red-cell-aplasia
#6
Suresh Kumar Balasubramanian, Meena Sadaps, Swapna Thota, Mai Aly, Bartlomiej P Przychodzen, Cassandra M Hirsch, Valeria Visconte, Tomas Radivoyevitch, Jaroslaw P Maciejewski
Pure red cell aplasia is an orphan disease without rationally established standard therapies. Most cases are idiopathic; a subset is antibody-mediated. There is overlap between idiopathic cases and those with T-large granular lymphocytic leukemia, hypogammaglobulinemia, and low-grade lymphomas. In all these, the pathogenetic mechanisms may involve autoreactive cytotoxic responses. We selected 62 uniformly diagnosed pure red cell aplasia patients and analyzed their pathophysiologic features and responsiveness to rationally applied first-line and salvage therapies to propose diagnostic and therapeutic algorithms that may help guide management of prospective patients...
December 7, 2017: Haematologica
https://www.readbyqxmd.com/read/29216845/a-comparison-of-the-test-negative-and-the-traditional-case-control-study-designs-for-estimation-of-influenza-vaccine-effectiveness-under-nonrandom-vaccination
#7
Meng Shi, Qian An, Kylie E C Ainslie, Michael Haber, Walter A Orenstein
BACKGROUND: As annual influenza vaccination is recommended for all U.S. persons aged 6 months or older, it is unethical to conduct randomized clinical trials to estimate influenza vaccine effectiveness (VE). Observational studies are being increasingly used to estimate VE. We developed a probability model for comparing the bias and the precision of VE estimates from two case-control designs: the traditional case-control (TCC) design and the test-negative (TN) design. In both study designs, acute respiratory illness (ARI) patients seeking medical care testing positive for influenza infection are considered cases...
December 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29216607/frequency-of-risk-factors-and-coexisting-abnormalities-in-a-population-of-egyptian-children-with-autism-spectrum-disorder
#8
Nagwa Abdel Meguid, Neveen Hassan Nashaat, Heba S Hashem, Mai M Khalil
BACKGROUND: Many risk factors interact together during the critical period of development and govern the future phenotype of autism spectrum disorder (ASD). Furthermore, co-occurring abnormalities among individuals with ASD vary a lot so as their abilities. AIM OF WORK: To investigate possible risk factors and to determine the prevalence of coexisting abnormalities in a sample of Egyptian ASD children and their influence on the severity and their communication performance...
December 1, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29215761/in-vivo-differentiation-of-common-basal-cell-carcinoma-subtypes-by-microvascular-and-structural-imaging-using-dynamic-optical-coherence-tomography
#9
Lotte Themstrup, Nathalie De Carvalho, Sabrina Mai Nielsen, Jonas Olsen, Silvana Ciardo, Sandra Schuh, Birgit Meinecke-Hansen Nørnberg, Julia Welzel, Martina Ulrich, Giovanni Pellacani, Gregor B E Jemec
BACKGROUND: The subtype of basal cell carcinoma (BCC) influences the choice of treatment. Optical coherence tomography (OCT) is a non-invasive imaging tool and recent development of angiographic version of OCT has extended the application of OCT to image the cutaneous microvasculature (so called dynamic OCT, D-OCT). This study explores D-OCT's ability to differentiate the common BCC subtypes by microvascular and structural imaging. METHODS: 81 patients with 98 BCC lesions, consisting of three subtypes: 27 superficial BCC (sBCC), 55 nodular BCC (nBCC) and 16 infiltrative BCC (iBCC), were D-OCT scanned at three European dermatology centres...
December 7, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29215466/sensitivity-of-takifugu-trpa1-to-thermal-stimulations-analyzed-in-oocytes-expression-system
#10
Mai Oda, Yoshihiro Kubo, Osamu Saitoh
Transient receptor potential ankyrin 1 (TRPA1s) from insects and several tetrapod vertebrates except rodents have been reported to be activated by high temperature with a relatively clear threshold. Our previous report, however, indicated that oocytes expressing zebrafish TRPA1b showed cold and heat-induced responses. Further, we also observed that zebrafish TRPA1b was gradually heat activated without a clear threshold. To study the possibility that these unique properties of thermal sensing of zebrafish TRPA1b are common to TRPA1s from other fish, we focused on the thermal response of pufferfish transient receptor potential ankyrin 1 (pfTRPA1) in the present study...
December 5, 2017: Neuroreport
https://www.readbyqxmd.com/read/29215154/analysis-of-factors-predicting-the-response-to-tolvaptan-in-patients-with-liver-cirrhosis-and-hepatic-edema
#11
Masanori Atsukawa, Akihito Tsubota, Keizo Kato, Hiroshi Abe, Noritomo Shimada, Toru Asano, Tadashi Ikegami, Mai Koeda, Tomomi Okubo, Taeang Arai, Ai Nakagawa-Iwashita, Yuji Yoshida, Korenobu Hayama, Norio Itokawa, Chisa Kondo, Yoshimichi Chuganji, Yasushi Matsuzaki, Katsuhiko Iwakiri
BACKGROUND AND AIM: This study aimed to clarify the factors predictive of treatment response to tolvaptan (V2-receptor antagonist) for cirrhotic patients with hepatic edema in a real-world setting. METHODS: In this retrospective, multicenter study, tolvaptan was orally administered at a dose of 7.5 mg once a day. Patients with a decrease in body weight of 1.5 kg or greater from baseline were characterized as responders at day 7. RESULTS: Of 229 patients, 210 were subjected to this analysis...
December 7, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29212927/mutations-in-the-pa-protein-of-avian-h5n1-influenza-viruses-affect-polymerase-activity-and-mouse-virulence
#12
Gongxun Zhong, Mai Quynh Le, Tiago J S Lopes, Peter Halfmann, Masato Hatta, Shufang Fan, Gabriele Neumann, Yoshihiro Kawaoka
To study the influenza viral determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012; QT1480) and 2013 (A/duck/Vietnam/QT1728/2013; QT1728) and found that the activity of their polymerase complexes differed significantly, even though both viruses were highly pathogenic in mice. Further studies revealed that the PA-S343A/E347D mutations reduced viral polymerase activity and mouse virulence when tested in the genetic background of QT1728 virus...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29212795/degradation-pathway-of-plant-complex-type-n-glycans-identification-and-characterization-of-a-key-%C3%AE-1-3-fucosidase-from-glycoside-hydrolase-family-29
#13
Shun Kato, Megumi Hayashi, Mai Kitagawa, Hiroyuki Kajiura, Megumi Maeda, Yoshinobu Kimura, Kiyohiko Igarashi, Masahiro Kasahara, Takeshi Ishimizu
Plant complex-type N -glycans are characterized by the presence of α1,3-linked fucose towards the proximal N -acetylglucosamine residue and β1,2-linked xylose towards the β-mannose residue. These glycans are ultimately degraded by the activity of several glycoside hydrolases. However, the degradation pathway of plant complex-type N -glycans have not been entirely elucidated because the gene encoding α1,3-fucosidase, a glycoside hydrolase acting on plant complex-type N -glycans, has not yet been identified, and its substrate specificity remains to be determined...
December 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29212190/artesunate-modified-nano-graphene-oxide-for-chemo-photothermal-cancer-therapy
#14
Yilin Pang, Zihao Mai, Bin Wang, Lu Wang, Liping Wu, Xiaoping Wang, Tongsheng Chen
Poor water-solubility of artesunate (ARS) hampers its clinical application. We here covalently linked ARS to PEGylated nanographene oxide (nGO-PEG) to obtain ARS-modified nGO-PEG (nGO-PEG-ARS) with excellent photothermal effect and dispersibility in physiological environment. nGO-PEG-ARS induced reactive oxygen species (ROS) and peroxynitrite (ONOO─) generations. Although nGO-PEG with near-infrared (NIR) irradiation did not induce cytotoxicity, the photothermal effect of nGO-PEG under NIR irradiation enhanced not only cell uptake but also ONOO─ generation of nGO-PEG-ARS, resulting in the synergistic chemo-photothermal effect of nGO-PEG-ARS in killing HepG2 cells...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210341/-without-this-program-women-can-lose-their-lives-migrant-women-s-experiences-with-the-safe-abortion-referral-programme-in-chiang-mai-thailand
#15
Ellen Tousaw, Ra Khin La, Grady Arnott, Orawee Chinthakanan, Angel M Foster
For displaced and migrant women in northern Thailand, access to health care is often limited, unwanted pregnancy is common, and unsafe abortion is a major contributor to maternal death and disability. Based on a pilot project and situational analysis research, in 2015 a multinational team introduced the Safe Abortion Referral Programme (SARP) in Chiang Mai, Thailand, to reduce the socio-linguistic, economic, documentation, and transportation barriers women from Burma face in accessing safe and legal abortion care in Thailand...
December 6, 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29210160/-dumbbell-and-clackers-shaped-dimeric-derivatives-of-monocarba-closo-dodecaborate
#16
Yu Kitazawa, Mamoru Watanabe, Yui Masumoto, Mai Otsuka, Kazunori Miyamoto, Atsuya Muranaka, Daisuke Hashizume, Ryo Takita, Masanobu Uchiyama
We designed, synthesized and characterized two types of dimeric forms of monocarba-closo-dodecaborate, namely, a "dumbbell"-shaped dianion having a C-C bond and a "clackers"-shaped monoanion having an iodonium linker. The unique architectures of these anionic molecules were established by X-ray analysis. Spectroscopic analysis, DFT calculations, and reactivity experiments revealed high anionic and chemical stability of both anions, which are crucial properties for weakly coordinating anions.
December 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29209912/restoration-of-smn-expression-in-mesenchymal-stem-cells-derived-from-gene-targeted-patient-specific-ipscs
#17
Mai Feng, Cong Liu, Yan Xia, Bo Liu, Miaojin Zhou, Zhuo Li, Qianru Sun, Zhiqing Hu, Yanchi Wang, Lingqian Wu, Xionghao Liu, Desheng Liang
Spinal muscular atrophy (SMA) is primarily a neurodegenerative disease caused by the homozygous deletion of the survival motor neuron 1 (SMN1) gene, thereby reducing SMN protein expression. Mesenchymal stem cells (MSCs) have been implicated in the treatment of SMA. In the present study, we overexpressed exogenous SMN1 at the ribosomal DNA (rDNA) locus of induced pluripotent stem cells (iPSCs) generated from a SMA patient using an rDNA-targeting vector. The gene-targeted patient iPSCs differentiated into MSCs (SMN1-MSCs)...
December 5, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29208665/cognitive-trajectories-from-infancy-to-early-adulthood-in-the-epicure-cohort-time-to-refocus-research-on-how-to-break-the-natural-limits-of-brain-plasticity
#18
EDITORIAL
Thuy Mai Luu, Anne-Monique Nuyt
No abstract text is available yet for this article.
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29208568/overexpression-of-elf3-facilitates-cell-growth-and-metastasis-through-pi3k-akt-and-erk-signaling-pathways-in-non-small-cell-lung-cancer
#19
Hao Wang, Zhiqi Yu, Shaofen Huo, Zheng Chen, Zhiling Ou, Jiajie Mai, Shangwei Ding, Jinshan Zhang
ELF3 is one of the member of transcription factors from E-twenty-six family, its role varies in different types of cancer. However, the role and specific mechanisms of ELF3 in the development of non-small cell lung cancer (NSCLC) still remains largely unknown. In our study, ELF3 was observed to be upregulated in NSCLC tissues compared to the corresponding normal lung tissue at mRNA and protein levels, and its expression level was correlated with the overall survival of patients with NSCLC. Silencing of the ELF3 gene in NSCLC cells inhibited the proliferation and metastasis significantly in vitro and in vivo...
December 2, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29207908/a-scoping-review-of-pain-in-children-following-traumatic-brain-injury-is-there-more-than-headache
#20
Vivian Kwan, Mai Vo, Melanie Noel, Keith Owen Yeates
AIM: Headache is a common source of pain in children following traumatic brain injury (TBI); however, relatively little is known about non-headache pain in this pediatric population. The present review seeks to map the extant literature to determine the prevalence, characteristics, and impact of non-headache pain in children following TBI of all severities. RESULTS: Of 109 studies published on pain in children following a TBI, 95 (87%) were focused exclusively on headache pain and only 14 (13%) reported on non-headache pain or overall pain, with half (n = 7) in the form of case studies...
December 5, 2017: Journal of Neurotrauma
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