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https://www.readbyqxmd.com/read/29471234/influences-of-motorcycle-rider-and-driver-characteristics-and-road-environment-on-red-light-running-behavior-at-signalized-intersections
#1
Auearree Jensupakarn, Kunnawee Kanitpong
In Thailand, red light running is considered as one of the most dangerous behaviors at intersection. Red light running (RLR) behavior is the failure to obey the traffic control signal. However, motorcycle riders and car drivers who are running through red lights could be influenced by human factors or road environment at intersection. RLR could be advertent or inadvertent behavior influenced by many factors. Little research study has been done to evaluate the contributing factors influencing the red-light violation behavior...
February 19, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29469775/coexistence-of-keloids-and-pilomatricoma-in-a-patient-with-rubinstein-taybi-syndrome
#2
Yosuke Yagi, Yutaka Kuwatsuka, Misachi Asai, Mai Honda, Atsushi Utani
Rubinstein-Taybi syndrome (RTS) is an autosomaldominant hereditary disease, which contains many skeletal and organ anomalies as well as mental retardation. Although high incidence of keloids in RTS is known, it is difficult to find a detailed report on the clinical features of keloids. In the following letter, we report an RTS patient fulfilling diagnostic criteria whosuffered from both keloids and pilomatricoma. We also performed a literature search, which identified the possible involvement of the Wnt/β-catenin signaling pathway in the pathogenesis of these two skin lesions...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469217/effect-of-treatment-with-direct-acting-antivirals-on-body-mass-index-and-hepatic-steatosis-in-chronic-hepatitis-c
#3
Hend Ibrahim Shousha, Rasha Ahmed Abdelaziz, Sherief Musa Azab, Marwa Khairy, Shahira Ahmed Afifi, Mai Ismael Mehrez, Mohamed Ali Eshra, Ayman Yosry Abdelrahim
BACKGROUND: Direct Acting Agents (DAAs) have high cure rate but still lack the knowledge of their effect on hepatic steatosis in chronic hepatitis C (CHC). Controlled Attenuation Parameter (CAP), evaluated with transient elastography, could help in assessment of steatosis grades. We aim to evaluate the effect of DAAs on BMI and steatosis in CHC using CAP. PATIENTS AND METHODS: This cohort study included 155 CHC Egyptian patients divided into three groups according to the DAAs regimens...
February 22, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29468899/markhacanasin-c-cycloartane-triterpenoid-from-the-leaves-of-markhamia-stipulata-var-canaense-v-s-dang
#4
Trong Nghia Ngo, Cong Thin Vo, Nguyen Kim Tuyen Pham, Nhat Minh Phan, Trong Dat Bui, Quoc Luan Ngo, Van Son Dang, Cong Luan Tran, Dinh Tri Mai, Tan Phat Nguyen
One new cycloartane triterpenoid, named markhacanasin C (1), together with three known triterpenoids, oleanolic acid (2), ursolic acid (3) and 6β,19α-dihydroxyursolic acid (4) were isolated by various chromatographic methods from the most cytotoxic fraction of the ethyl acetate extract of Markhamia stipulata var. canaense V.S. Dang leaves. Among them, 4 was reported for the first time from the genus Markhamia, while 2 and 3 were found for the first time from this species. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR experiments...
February 22, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29466787/a-strategy-for-optimizing-the-combination-of-active-components-based-on-chinese-medicinal-formula-sheng-mai-san-for-myocardial-ischemia
#5
Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu
BACKGROUND/AIMS: Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization...
February 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29466424/anterior-segment-and-external-ocular-disorders-associated-with-hiv-infections-in-the-era-of-haart-in-chiang-mai-university-hospital-a-prospective-descriptive-cross-sectional-study
#6
Tassapol Singalavanija, Somsanguan Ausayakhun, Chulaluck Tangmonkongvoragul
Human immunodeficiency virus (HIV) causes impairment to the human immune system which leads to immunocompromised conditions, including ocular complications. Several important HIV-associated disorders may involve the anterior segment, ocular surface, and adnexae organ such as dry eye, blepharitis which reduce quality of life of patients. In present, potent antiretroviral therapies HAART (highly active antiretroviral therapy) has improved the length and quality of life which may lead to an increased prevalence of anterior segment ocular disorders...
2018: PloS One
https://www.readbyqxmd.com/read/29464796/drug-like-dietary-vanilloids-induce-anticancer-activity-through-proliferation-inhibition-and-regulation-of-bcl-related-apoptotic-proteins
#7
Chun-Wai Mai, Yew-Beng Kang, Vishna Devi Nadarajah, Ahmad Sazali Hamzah, Mallikarjuna Rao Pichika
In this study, a series of 20 structurally similar vanilloids (Vn) were tested for their antiproliferative effects against 12 human cancer cells: human breast (MCF-7 and MDA-MB-231), cervical (HeLa), ovarian (Caov-3), lung (A549), liver (HepG2), colorectal (HT-29 and HCT116), nasopharyngeal (CNE-1 and HK-1), and leukemic (K562 and CEM-SS) cancer cells. Among all the tested vanilloids, Vn16 (6-shogaol) exhibited the most potent cytotoxic effects against human colorectal cancer cells (HT-29). The apoptotic induction effects exhibited by Vn16 on HT-29 cells were confirmed using dual staining fluorescence microscopy and enzyme-linked immunosorbent assay...
February 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29463198/a-network-approach-for-provisional-assay-recognition-of-a-hendra-virus-antibody-elisa-test-validation-with-low-sample-numbers-from-infected-horses
#8
Axel Colling, Ross Lunt, Jemma Bergfeld, Leanne McNabb, Kim Halpin, Susan Juzva, Kim Newberry, Chris Morrissy, Cameron Loomes, Simone Warner, Ibrahim Diallo, Peter Kirkland, Christopher C Broder, Gemma Carlile, Mai Hlaing Loh, Caryll Waugh, Lynda Wright, James Watson, Debbie Eagles, Kurt Zuelke, Sam McCullough, Peter Daniels
Obtaining statistically sound numbers of sera from Hendra virus (HeV)-infected horses is problematic because affected individuals usually die or are euthanized before developing a serum antibody response. As a consequence, test validation becomes a challenge. Our approach is an extension of OIE principles for provisional recognition and included 7 validation panels tested across multiple laboratories that provided estimates for test performance characteristics. At a 0.4 S/P cutoff, 16 of 19 sera from HeV-infected horses gave positive results in the HeV soluble G, indirect ELISA (HeVsG iELISA; DSe 84...
February 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29461569/prevention-av-diabetes-typ-2-med-fysisk-aktivitet-och-h%C3%A3-lsosam-mat-en-framg%C3%A3-ngsrik-dialog-om-livsstil-bygger-p%C3%A3-individanpassade-och-evidensbaserade-r%C3%A3-d
#9
https://www.readbyqxmd.com/read/29460745/seroprevalence-of-dengue-and-chikungunya-virus-antibodies-french-polynesia-2014-2015
#10
Maite Aubry, Anita Teissier, Michael Huart, Sébastien Merceron, Jessica Vanhomwegen, Mihiau Mapotoeke, Teheipuaura Mariteragi-Helle, Claudine Roche, Anne-Laure Vial, Sylvianne Teururai, Sébastien Sicard, Sylvie Paulous, Philippe Desprès, Jean-Claude Manuguerra, Henri-Pierre Mallet, Allison Imrie, Didier Musso, Xavier Deparis, Van-Mai Cao-Lormeau
We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014-2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was <3% before and 76% after Zika virus emergence (2013). Dengue virus herd immunity may affect Zika virus infection and pathogenesis.
March 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29460390/safety-assessment-biological-effects-and-mechanisms-of-myrica-rubra-fruit-extract-for-anti-melanogenesis-anti-oxidation-and-free-radical-scavenging-abilities-on-melanoma-cells
#11
Lih-Jeng Juang, Xiang-Yu Gao, Shou-Ting Mai, Cheng-Hung Lee, Ming-Chung Lee, Chao-Ling Yao
OBJECTIVE: Currently, the cosmetic and medical industries are paying considerable attention to solve or prevent skin damage or diseases, such as hyperpigmentation and oxidation and free radical damage. In this study, the effective compounds in Myrica rubra fruit were extracted and studied the biological effects of these M. rubra fruit extracts. METHODS: In this study, we extracted M. rubra fruit using solutions with various ratios of water to ethanol (100:0, 50:50, 5:95) and studied the anti-melanogenesis, anti-oxidation and radical scavenging effects of these M...
February 20, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29459954/late-thrombectomy-reduced-disability-in-acute-stroke-with-mismatched-clinical-deficit-and-infarction-volume
#12
Lauren M Mai, Wes Oczkowski
No abstract text is available yet for this article.
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29459640/self-assembled-collagen-fibrin-hydrogel-reinforces-tissue-engineered-adventitia-vessels-seeded-with-human-fibroblasts
#13
Bijal Patel, Zhengfan Xu, Cameron B Pinnock, Loay S Kabbani, Mai T Lam
Efforts for tissue engineering vascular grafts focuses on the tunica media and intima, although the tunica adventitia serves as the primary structural support for blood vessels. In surgery, during endarterectomies, surgeons can strip the vessel, leaving the adventitia as the main strength layer to close the vessel. Here, we adapted our recently developed technique of forming vascular tissue rings then stacking the rings into a tubular structure, to accommodate human fibroblasts to create adventitia vessels in 8 days...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29458014/topical-delivery-of-l-theanine-ameliorates-tpa-induced-acute-skin-inflammation-via-downregulating-endothelial-pecam-1-and-neutrophil-infiltration-and-activation
#14
Wei-Jie Zeng, Zhi Tan, Xing-Fei Lai, Ya-Nan Xu, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Xian-Guo Liu, Shi-Li Sun, Li-Jun Zhou
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of l-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 μg/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of l-theanine 30 min before TPA time- and dose-dependently suppressed the increases in both skin thickness and weight...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457181/ab-initio-kinetics-of-the-hoso-2-3-o-2-%C3%A2-so-3-ho-2-reaction
#15
Tam V-T Mai, Minh V Duong, Hieu T Nguyen, Lam K Huynh
The detailed kinetic mechanism of the HOSO2 +3 O2 reaction, which plays a pivotal role in the atmospheric oxidation of SO2 , was investigated using accurate electronic structure calculations and novel statistical thermodynamic/kinetic models. Explored using the accurate composite method W1U, the detailed potential energy surface (PES) revealed that the addition of O2 to a HOSO2 radical to form the adduct (HOSO4 ) proceeds via a transition state with a slightly positive barrier (i.e., 0.7 kcal mol-1 at 0 K)...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29456748/wound-closure-expectations-after-fasciotomy-for-paediatric-compartment-syndrome
#16
E D Shirley, V Mai, K M Neal, G M Kiebzak
Purpose: Acute compartment syndrome often requires additional surgery to achieve wound closure. Little information exists regarding the expected number of surgeries, techniques and complications after closure in paediatric patients. Methods: A retrospective chart review identified patients treated for acute compartment syndrome at four hospitals over a ten-year period. The cause of injury, type of dressing, number of surgeries, type of closure and complications were recorded...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29455928/transcriptional-regulation-of-the-warburg-effect-in-cancer-by-six1
#17
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth...
February 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29455820/ductus-aneurysm-ruptured-into-the-esophagus-with-massive-bleeding
#18
Takeshi Soeda, Mai Sakashita, Takamitsu Hamada, Yuhei Saito, Yasuhito Kitakado, Nobuo Morioka
We report a patient with life-threatening hematemesis caused by the rupture of a ductus aneurysm into the esophagus, which was successfully treated by coil embolism for the esophageal fistula through the aorta and subsequent thoracic endovascular aortic replacement. Second-stage therapy was performed surgically after proactive antibiotic treatment and in consideration of the patient's improved general condition. This included debridement with drainage, aortic encasement with remnant aneurysmal wall, omentopexy, and jejunostomy...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29454596/comparatively-study-on-the-insulin-regulated-glucose-homeostasis-through-brain-gut-peptides-in-japanese-flounder-paralichthys-olivaceus-after-intraperitoneal-and-oral-administration-of-glucose
#19
Dong Liu, Benyue Guo, Dongdong Han, Kangyu Deng, Zhixiang Gu, Mengxi Yang, Wei Xu, Wenbing Zhang, Kangsen Mai
The present study comparatively analyzed the blood glucose and insulin concentration, the temporal and spatial expression of brain-gut peptides and the key enzymes of glycolysis and gluconeogenesis in Japanese flounder by intraperitoneal injection (IP) and oral administration (OR) of glucose. Samples were collected at 0, 1, 3, 5, 7, 9, 12, 24 and 48h after IP and OR glucose, respectively. Results showed that the hyperglycemia lasted for about 10 hours and 21 hours in OR and IP group, respectively. The serum insulin concentration significantly decreased at 3h (1...
February 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29454585/the-hot-cross-bun-sign-in-a-patient-with-encephalitis
#20
Yingyan Gan, Huici Liang, Xiaojing Li, Yiru Zeng, Wenlin Wu, Jing Han, Jianning Mai
The 'hot cross' bun (HCB) sign refers to pontine cruciform hyperintensity on T2 weighted magnetic resonance image (MRI) which is frequently seen in multiple system atrophy and spinocerebellar ataxia types 2 and 3. We describe a 3 years old boy of encephalitis and his MRI image showed HCB sign in the pontine. After immunosuppressive treatment and followed up 14 months, he got a good outcome and the HCB sign narrowed nearly disappeared.
February 14, 2018: Brain & Development
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