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https://www.readbyqxmd.com/read/29145709/defining-a-unified-vascular-phenotype-in-systemic-sclerosis
#1
REVIEW
Yannick Allanore, Oliver Distler, Marco Matucci-Cerinic, Christopher P Denton
Microcirculation impairment and related vasculopathy is a hallmark of systemic sclerosis. Digital ulcers are second only to Raynaud's phenomenon as a vascular complication occurring in scleroderma patients. Digital ulcers are painful and generate disability. Furthermore, patients may develop recurrent digital ulcers and one may ask whether the outcomes of such patients might be different to those of unaffected ones. Recently several registries have provided relevant information about digital ulcers. Male sex and severe skin disease seem to be the main associated factors observed in several registries...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29143961/upregulation-of-epidermal-gap-junctional-proteins-in-patients-with-venous-disease
#2
M Kanapathy, R Simpson, L Madden, C Thrasivoulou, A Mosahebi, D L Becker, T Richards
BACKGROUND: Leg ulceration is a feared complication of venous insufficiency. It is not known whether varicose veins predispose skin to poor wound healing. The expression pattern of gap junctional protein connexin, a known marker of poor wound healing, was investigated across various stages of venous disease. METHODS: Patients undergoing intervention for varicose veins were assessed according to the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification of varicose veins...
November 16, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29141833/comparative-study-of-the-clinical-histological-and-biological-characteristics-of-squamous-cell-carcinomas-in-areas-previously-treated-with-photodynamic-therapy
#3
Tamara Gracia Cazaña, Nerea Salazar, Jesús Vera-Álvarez, Salvador González, Angeles Juarranz, Yolanda Gilaberte
Although photodynamic therapy (PDT) is an effective treatment option for non-melanoma skin cancer, the development of aggressive tumours in PDT-treated areas has been described. To evaluate the clinical, histological, and biological characteristics of squamous cell carcinomas (SCCs) in areas previously treated with PDT vs those arising in areas never treated with this therapeutic modality. A retrospective observational study was designed. We collected all cases of invasive SCCs in areas previously treated with PDT...
November 15, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29140838/assessing-specimens-of-devitalized-tissue-in-chronic-sacral-pressure-ulcers-a-pilot-study
#4
Juliany Lino Gomes Silva, Andressa Coope, Eliana Pereira de Araújo, Licio A Velloso, Mário José A Saad, Maria Helena Melo Lima
Pressure ulcers (PrUs)* are chronic wounds caused by a combination of factors, such as repetitive ischemia perfusion injury, bacterial colonization of the wound bed, local tissue hypoxia, or an altered cellular and systemic stress response. The objectives of this study were to analyze fragments of devitalized tissue of Stages III and IV PrUs and compare them with healthy tissue to evaluate the expression of the genes involved in wound inflammation. Samples of healthy skin from patients undergoing plastic surgery (n = 3) were collected, as well as from patients with devitalized tissue from Stages III and IV PrUs (n = 3) by means of sharp debridement...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29140836/pyoderma-gangrenosum-a-critical-appraisal
#5
Eran Shavit, Afsaneh Alavi, R Gary Sibbald
GENERAL PURPOSE: To provide information about pyoderma gangrenosum (PG), including pathophysiology, diagnostic criteria, and treatment. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Pyoderma gangrenosum (PG) is an uncommon cutaneous disease, presenting with recurrent painful ulcerations most commonly on the lower extremities...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29132305/associations-between-skin-barrier-characteristics-skin-conditions-and-health-of-aged-nursing-home-residents-a-multi-center-prevalence-and-correlational-study
#6
Elisabeth Hahnel, Ulrike Blume-Peytavi, Carina Trojahn, Jan Kottner
BACKGROUND: Geriatric patients are affected by a range of skin conditions and dermatological diseases, functional limitations and chronic diseases. Skin problems are highly prevalent in elderly populations. Aim of this study was to investigate possible associations between health, functional and cutaneous variables in aged long-term care residents. METHODS: This observational, cross-sectional, descriptive prevalence study was conducted in a random sample of 10 institutional long-term care facilities in Berlin...
November 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29130957/clinical-disease-patterns-in-a-regional-swiss-cohort-of-34-pyoderma-gangrenosum-patients
#7
Antonios G A Kolios, Alissa Gübeli, Barbara Meier, Julia-Tatjana Maul, Thomas Kündig, Jakob Nilsson, Jürg Hafner, Emmanuella Guenova, Katrin Kerl, Mark Anliker, Werner Kempf, Alexander A Navarini, Lars E French, Antonio Cozzio
BACKGROUND/AIM: Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis often associated with an underlying disease, and clinical data or larger studies are rare. METHODS: In this retrospective study, disease characteristics, clinical manifestations, and treatment response were evaluated in a Swiss cohort of PG patients. RESULTS: In participating centers, 34 cases (21 females) of PG were analyzed based on clinical and histological presentation between 2002 and 2012...
November 7, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29126413/leaves-from-banana-musa-nana-and-maize-zea-mays-have-no-phyto-prophylactic-effects-on-the-susceptibility-of-grass-carp-ctenopharyngodon-idella-to-aeromonas-hydrophila-infection
#8
Richard Mayrhofer, Simon Menanteau-Ledouble, Johannes Pucher, Ulfert Focken, Mansour El-Matbouli
BACKGROUND: The ubiquitous and opportunistic bacterial pathogen Aeromonas hydrophila has been associated with ulcerative dermatitis in fish, especially under stressful conditions. It can cause severe losses in fresh water aquaculture and is particularly prevalent in tropical and subtropical regions. Fresh leaves from maize and bananas have been used as feed supplement by fish farmers in Vietnam and it has been reported that they may have phyto-prophylactic benefits. In the present study, a feeding trial was conducted to investigate the benefits of providing maize and banana leaves as feed supplement: to determine if they were taken up and digested by grass carp (Ctenopharyngodon idella), if this uptake resulted in improved growth performance, and if leaf supplementation protected fish when challenged with A...
November 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29126283/surgical-management-of-penile-lesions-secondary-to-foreign-body-reaction-a-case-report-and-systematic-review
#9
Pedro L S Faveret, Fábio Santiago
Background: To improve the penile contour, some men choose to undergo implantation or injection of nonbiological materials. Foreign body reactions in penile tissue may produce scarring, deformity, ulceration, necrosis, and even gangrene. Consensus is lacking regarding the most effective surgical procedure for reconstruction of these penile lesions. Objectives: The authors describe one case study and the first systematic review focusing on reconstructive surgical management for penile lesions secondary to foreign body reaction...
November 6, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29125346/prevention-and-management-of-incontinence-associated-dermatitis
#10
David Voegeli
David Voegeli, Associate Professor of Nursing, Skin Health Research Group, Faculty of Health Sciences, University of Southampton, discusses the care of patients with incontinence-associated dermatitis and how to distinguish this condition from pressure ulcers.
November 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29120893/ce-pressure-injuries-caused-by-medical-devices-and-other-objects-a-clinical-update
#11
Barbara Ann Delmore, Elizabeth A Ayello
A review of practical resources, including mnemonics, to aid in prevention and identification. ABSTRACT: At the April 2016 National Pressure Ulcer Advisory Panel (NPUAP) consensus conference, terminology and staging definitions were updated and two definitions were revised to describe pressure injuries (PIs) caused by medical devices or other items on the skin or mucosa. Here, the authors discuss the etiology and prevention of PIs resulting from medical and other devices, the frequency of such injuries, and the bodily sites at which they most often occur...
November 8, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/29120855/the-application-of-l-prp-in-aids-patients-with-crural-chronic-ulcers-a-pilot-study
#12
Agata Cieslik-Bielecka, Rafał Skowroński, Magdalena Jędrusik-Pawłowska, Marcin Pierchała
Nonhealing wounds or skin ulcerations are the result of insufficient repair and destruction of a local healing potential. Opportunistic infections which cause a lot of ulcer complications influence the worsening general condition of patients with AIDS, ultimately leading to death. The chronicity of the condition and poor results of conventional therapy have prompted the search for new methods of treatment. We have examined venous or arteriovenous insufficiency-related extensive crural ulcers in AIDS patients...
November 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29120687/a-100-patient-clinical-evaluation-of-an-alternating-pressure-replacement-mattress-in-a-home-based-setting
#13
Jackie Stephen-Haynes, Rosie Callaghan
BACKGROUND: alternating pressure air mattresses (APAMs) support the prevention and management of pressure ulcers. A health and care NHS trust was seeking an APAM that would improve clinical outcomes in relation to pressure ulcers while considering financial cost. An APAM existed that could meet the trust's needs but there was a lack of evidence over its use in a community/home setting. This study examined the effect of using the Dual Professional (IQ Medical) APAM for patients at a high risk of pressure ulceration...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29120686/why-is-the-heel-particularly-vulnerable-to-pressure-ulcers
#14
Amit Gefen
In this article, the vulnerability of the soft tissues of the heel to pressure ulcers (injuries) is explained from a biomechanical engineering perspective, and emerging technologies for protecting the heel, particularly low-friction garments, are reviewed. Sustained deformations in the soft tissue of the weight-bearing posterior heel cause progressive cell and tissue damage due to loss of homeostasis in the cells, as the cytoskeleton and plasma membranes of the affected cells lose integrity and functionality...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29120684/managing-exudate-and-maceration-in-venous-leg-ulceration-within-the-acute-health-setting
#15
Annemarie Brown
Exudate has beneficial effects in normal wound healing but detrimental consequences for chronic wounds. Practitioners need to identify and treat its cause, and manage the exudate and prevent if from damaging periwound skin. Management involves dressings of the most appropriate absorbency and other products, and avoiding maceration of periwound skin; compression therapy is the gold standard treatment for treating oedema and venous leg ulceration. Nurses in acute settings may not have the skills to implement or maintain compression therapy; this article is intended for nurses who may have to manage these patients temporarily while they are admitted to secondary care and may not have the skills...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29115209/exploring-the-use-of-ingenol-mebutate-to-prevent-non-melanoma-skin-cancer
#16
Andrés Már Erlendsson
Non-melanoma skin cancer is the most frequently occurring cancer in Caucasians today. Incidence rates in Europe have increased steadily since the 1960s and more than tripled over the last 50 years. Despite primary preventative efforts, incidences of non-melanoma skin cancer continue to rise and development of effective chemopreventative strategies is needed. In 2013, ingenol mebutate was approved in Denmark as a new topical drug for field-directed treatment for actinic keratoses. Ingenol mebutate has a dual mechanism of action, causing initial cell death, followed by an immune activation...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29115054/comparison-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-with-healthy-fibroblasts-on-wound-healing-activity-of-diabetic-fibroblasts
#17
Jae-A Jung, Young-Don Yoon, Hyup-Woo Lee, So-Ra Kang, Seung-Kyu Han
Various types of skin substitutes composed of fibroblasts and/or keratinocytes have been used for the treatment of diabetic ulcers. However, the effects have generally not been very dramatic. Recently, human umbilical cord blood-derived mesenchymal stromal cells (hUCB-MSCs) have been commercialised for cartilage repair as a first cell therapy product using allogeneic stem cells. In a previous pilot study, we reported that hUCB-MSCs have a superior wound-healing capability compared with fibroblasts. The present study was designed to compare the treatment effect of hUCB-MSCs with that of fibroblasts on the diabetic wound healing in vitro...
November 7, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29107621/effectiveness-of-single-dose-azithromycin-to-treat-latent-yaws-a-longitudinal-comparative-cohort-study
#18
Oriol Mitjà, Camila González-Beiras, Charmie Godornes, Reman Kolmau, Wendy Houinei, Haina Abel, August Kapa, Raymond Paru, Sibauk V Bieb, James Wangi, Sergi Sanz, Kingsley Asiedu, Sheila A Lukehart, Quique Bassat
BACKGROUND: Treatment of latent yaws is a crucial component of the WHO yaws eradication strategy to prevent relapse and the resulting transmission to uninfected children. We assessed the effectiveness of single-dose azithromycin to treat patients with latent yaws. METHODS: This population-based cohort study included children (age <20 years) living on Lihir Island, Papua New Guinea, with high-titre (rapid plasma reagin titre ≥1:8) latent or active yaws, between April, 2013, and May, 2015...
October 26, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29105657/gait-training-after-spinal-cord-injury-safety-feasibility-and-gait-function-following-8-weeks-of-training-with-the-exoskeletons-from-ekso-bionics
#19
Carsten Bach Baunsgaard, Ulla Vig Nissen, Anne Katrin Brust, Angela Frotzler, Cornelia Ribeill, Yorck-Bernhard Kalke, Natacha León, Belén Gómez, Kersti Samuelsson, Wolfram Antepohl, Ulrika Holmström, Niklas Marklund, Thomas Glott, Arve Opheim, Jesus Benito, Narda Murillo, Janneke Nachtegaal, Willemijn Faber, Fin Biering-Sørensen
STUDY DESIGN: Prospective quasi-experimental study, pre- and post-design. OBJECTIVES: Assess safety, feasibility, training characteristics and changes in gait function for persons with spinal cord injury (SCI) using the robotic exoskeletons from Ekso Bionics. SETTING: Nine European rehabilitation centres. METHODS: Robotic exoskeleton gait training, three times weekly over 8 weeks. Time upright, time walking and steps in the device (training characteristics) were recorded longitudinally...
November 6, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29099568/a-case-report-on-suspected-levamisole-induced-pseudovasculitis
#20
Tiffany Fan, Jeffrey Macaraeg, Toufik Mahfood Haddad, Holly Bacon, Duc Le, Mohsin Mirza, Carrie Valenta, Tammy Wichman
INTRODUCTION: Levamisole-induced pseudovasculitis should be considered in patients with inconsistent anti-neutrophil cytoplasmic antibodies (ANCA) pattern and history of cocaine use. CASE PRESENTATION: A 50-year-old man presented to the emergency department with symptoms of bilateral pulmonary emboli. His hospital course was complicated by multiple end organ failure, which improved dramatically with prednisone. Although he was diagnosed previously with granulomatosis with polyangiitis due to positive proteinase 3 (PR3), myeloperoxidase (MPO), perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) and cytoplasmic anti-neutrophil cytoplasmic antibodies (C-ANCA) markers, his longstanding cocaine use and history of skin ulcers, thrombotic events, and febrile illnesses suggested a diagnosis of levamisole-induced pseudovasculitis instead...
February 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
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