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https://www.readbyqxmd.com/read/28822990/%C3%AE-%C3%AE-mangostins-induces-autophagy-and-shows-synergistic-effectwith-gemcitabine-in-pancreatic-cancer-cell-lines
#1
Myoungjae Kim, Young-Won Chin, Eun Joo Lee
Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was to determine the anti-pancreatic cancer effect of α-mangostin (αM) and γ-mangostin (γM) extracted from the pericarp of Garcinia mangostana L.. Both αM and γM reduced the viability of pancreatic cancer cells MIA PaCa-2 and PANC-1 in a dose-dependent manner. These compounds induced apoptosis by increasing c-PARP and c-Caspase 3 levels...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28817560/fruit-weight-is-controlled-by-cell-size-regulator-encoding-a-novel-protein-that-is-expressed-in-maturing-tomato-fruits
#2
Qi Mu, Zejun Huang, Manohar Chakrabarti, Eudald Illa-Berenguer, Xiaoxi Liu, Yanping Wang, Alexis Ramos, Esther van der Knaap
Increases in fruit weight of cultivated vegetables and fruits accompanied the domestication of these crops. Here we report on the positional cloning of a quantitative trait locus (QTL) controlling fruit weight in tomato. The derived allele of Cell Size Regulator (CSR-D) increases fruit weight predominantly through enlargement of the pericarp areas. The expanded pericarp tissues result from increased mesocarp cell size and not from increased number of cell layers. The effect of CSR on fruit weight and cell size is found across different genetic backgrounds implying a consistent impact of the locus on the trait...
August 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28798491/phytochromobilin-deficiency-impairs-sugar-metabolism-through-the-regulation-of-cytokinin-and-auxin-signaling-in-tomato-fruits
#3
Ricardo Ernesto Bianchetti, Aline Bertinatto Cruz, Bruna Soares Oliveira, Diego Demarco, Eduardo Purgatto, Lázaro Eustáquio Pereira Peres, Magdalena Rossi, Luciano Freschi
Phytochomes and plant hormones have been emerging as important regulators of fleshy fruit biology and quality traits; however, the relevance of phytochrome-hormonal signaling crosstalk in controlling fruit development and metabolism remains elusive. Here, we show that the deficiency in phytochrome chromophore phytochromobilin (PΦB) biosynthesis inhibits sugar accumulation in tomato (Solanum lycopersicum) fruits by transcriptionally downregulating sink- and starch biosynthesis-related enzymes, such as cell-wall invertases, sucrose transporters and ADP-glucose pyrophosphorylases...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28778007/application-of-saponin-biosurfactant-and-its-recovery-in-the-meuf-process-for-removal-of-methyl-violet-from-wastewater
#4
Kulbhushan Samal, Chandan Das, Kaustubha Mohanty
The potential of saponin, a biosurfactant, in the micellar enhanced ultrafiltration (MEUF) process was tested systematically for removal of methyl violet from wastewater. For this, the aqueous extract of reetha (Sapindus mukorossi) pericarp which contains saponin was used as the biosurfactant. First, the micellar solubilization of methyl violet in saponin micelles was investigated in terms of molar solubilization power (SP) of saponin. It was observed that the adsorption of methyl violet on the agglomerates of saponin micelles was mainly responsible for the enhanced solubilization...
August 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28767887/clusia-criuva-cambess-clusiaceae-anatomical-characterization-chemical-prospecting-and-antioxidant-activity
#5
Karla M M DA Silva, Andrea B DA Nóbrega, Bruno Lessa, Maria Carolina Anholeti, Adriana Q Lobão, Alessandra L Valverde, Selma R DE Paiva, Ana Joffily
This study aims the anatomical description and chemical characterization of aerial parts of Clusia criuva Cambess., Clusiaceae in addition to the evaluation of the antioxidant activity of crude extracts, correlated to the flavonoid content. The morphological characterization was performed using traditional techniques of plant anatomy. For phytochemical studies, crude extracts were obtained by static maceration and analyzed by thin layer chromatography. The antioxidant activity and the flavonoids content were determined by colorimetric methods involving, respectively, 2,2-diphenyl-1-picrylhydrazyl free radical and aluminum chloride...
July 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28759629/genetic-and-morphological-analyses-of-gracilaria-firma-and-g-changii-gracilariaceae-rhodophyta-the-commercially-important-agarophytes-in-western-pacific
#6
Poh-Kheng Ng, Showe-Mei Lin, Phaik-Eem Lim, Anicia Q Hurtado, Siew-Moi Phang, Yoon-Yen Yow, Zhongmin Sun
Many studies classifying Gracilaria species for the exploitation of agarophytes and the development of the agar industry were conducted before the prevalence of molecular tools, resulting in the description of many species based solely on their morphology. Gracilaria firma and G. changii are among the commercially important agarophytes from the western Pacific; both feature branches with basal constrictions that taper toward acute apices. In this study, we contrasted the morpho-anatomical circumscriptions of the two traditionally described species with molecular data from samples that included representatives of G...
2017: PloS One
https://www.readbyqxmd.com/read/28759152/anthocyanins-from-purple-corn-ameliorated-tnf-%C3%AE-induced-inflammation-and-insulin-resistance-in-3t3-l1-adipocytes-via-activation-of-insulin-signaling-and-enhanced-glut4-translocation
#7
Diego Luna-Vital, Matthew Weiss, Elvira Gonzalez de Mejia
SCOPE: The aim was to compare the effect of an anthocyanin-rich extract from purple corn pericarp (PCW) and pure anthocyanins on adipogenesis, inflammation and insulin resistance in 3T3-L1 adipocytes on basal and inflammatory conditions. METHODS AND RESULTS: Preadipocytes (3T3-L1) were treated during differentiation with or without PCW. Differentiated adipocytes were treated either individually or in combination with tumor necrosis factor TNF-α and PCW, or pure C3G, Pg3G, P3G...
July 31, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28744920/anti-myocardial-ischemia-effect-and-components-of-litchi-pericarp-extracts
#8
Yanfen Chen, Huanqing Li, Shu Zhang, Chaoyan Yang, Ziying Mai, Xueyan Hu, Zhenhu Gao, Hong Deng
Litchi (Litchi chinensis Sonn.) is a famous fruit in south China, and it is also effective for chest tightness or chest pain, irritability, flatulence, epigastric pain and neuralgic pain, hernia pain and testicular swelling, cough, etc. It is valued because a great amount of polyphenol was found in litchi pericarp. In this paper, we got litchi pericarp pure extract by a simple purification method, then evaluated its activity to clear oxygen free radicals in vitro, and evaluated its myocardial protection effect in vivo through acute myocardial ischemia rat model...
July 26, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28743310/the-effect-of-frequency-specific-sound-signals-on-the-germination-of-maize-seeds
#9
Carlos M Vicient
OBJECTIVE: The effects of sound treatments on the germination of maize seeds were determined. RESULTS: White noise and bass sounds (300 Hz) had a positive effect on the germination rate. Only 3 h treatment produced an increase of about 8%, and 5 h increased germination in about 10%. Fast-green staining shows that at least part of the effects of sound are due to a physical alteration in the integrity of the pericarp, increasing the porosity of the pericarp and facilitating oxygen availability and water and oxygen uptake...
July 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28736485/origin-of-rice-oryza-sativa-l-domestication-genes
#10
Peter Civáň, Terence A Brown
A number of genes that contribute to the domestication traits of cultivated rice have been identified. These include Sh4, Rc, PROG1 and LABA1, which are associated with non-shattering rachis, white pericarp, erect growth and barbless awns, respectively. The mutations giving rise to the "domestication alleles" of these genes are either invariable in cultivated rice, or have variability that is strictly associated with the phenotypic trait. This observation forms the basis to those current rice domestication models that envisage a single origin for the domesticated phenotype...
2017: Genetic Resources and Crop Evolution
https://www.readbyqxmd.com/read/28731316/phytochemical-analysis-of-myrtus-communis-plant-conventional-versus-microwave-assisted-extraction-procedures
#11
Nadia Bouaoudia-Madi, Lila Boulekbache-Makhlouf, Nabil Kadri, Farid Dahmoune, Hocine Remini, Sofiane Dairi, Sonia Oukhmanou-Bensidhoum, Khodir Madani
Background Myrtle (Myrtus communis L) may constitute an interesting dietary source of health protective compounds. Microwave-assisted extraction (MAE) of total phenolic compounds (TPC) from myrtle leaf, stems, pericarp, and seeds was studied and the results were compared with those of the conventional method extraction (CME) in terms of extraction time. Methods Extraction yield/efficiency and antioxidant activity were measured using radical scavenging assay (DPPH•) and reducing power. Results The results show that the MAE was higher in terms of saving energy, extraction time (62 s) and extraction efficiency of bioactive compound compared to CME (2 h)...
June 10, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28725039/surface-chemistry-and-germination-improvement-of-quinoa-seeds-subjected-to-plasma-activation
#12
A Gómez-Ramírez, C López-Santos, M Cantos, J L García, R Molina, J Cotrino, J P Espinós, A R González-Elipe
Plasma treatment is recognized as a suitable technology to improve germination efficiency of numerous seeds. In this work Quinoa seeds have been subjected to air plasma treatments both at atmospheric and low pressure and improvements found in germination rate and percentage of success. Seed water uptake by exposure to water vapor, although slightly greater for plasma treated seeds, did not justify the observed germination improvement. To identify other possible factors contributing to germination, the chemical changes experienced by outer parts of the seed upon plasma exposure have been investigated by X-ray photoemission spectroscopy (XPS) and scanning electron microscopy (SEM-EDX)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724949/overexpression-of-slpre2-an-atypical-bhlh-transcription-factor-affects-plant-morphology-and-fruit-pigment-accumulation-in-tomato
#13
Zhiguo Zhu, Guoping Chen, Xuhu Guo, Wencheng Yin, Xiaohui Yu, Jingtao Hu, Zongli Hu
The basic helix-loop-helix (bHLH) proteins are a large family of transcription factors that control various developmental processes in eukaryotes, but the biological roles of most bHLH proteins are not very clear, especially in tomato. In this study, a PRE-like atypical bHLH gene was isolated and designated as SlPRE2 in tomato. SlPRE2 was highly expressed in immature-green fruits, moderately in young leaves, flowers, and mature-green fruits. To further research the function of SlPRE2, a 35 S:PRE2 binary vector was constructed and transformed into wild type tomato...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724331/randomized-double-blinded-pilot-clinical-study-of-the-antidiabetic-activity-of-balanites-aegyptiaca-and-uplc-esi-ms-ms-identification-of-its-metabolites
#14
Hend Rashad, Fateheya M Metwally, Shahira M Ezzat, Maha M Salama, Adel Hasheesh, Amira Abdel Motaal
CONTEXT: Balanites aegyptiaca Del. (Zygophyllaceae) fruits are traditionally known for the treatment of hyperglycaemia. Several in vitro and in vivo studies proposed some mechanisms of action. However, clinical trials in human beings were never reported to date. OBJECTIVES: To investigate the antidiabetic efficacy of the 70% ethanol extract of the pericarps of B. aegyptiaca (BE) within a nutritional intervention in elderly people. MATERIALS AND METHODS: Ultra-performance electrospray ionization-mass spectroscopy (UPLC-ESI-MS/MS) analysis was used for metabolic profiling of BE which was incorporated in hard gelatine capsules (400 mg/day) and tested on 30 type 2 diabetes (T2D) Egyptian patients for 8 weeks...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28720977/effect-of-integration-of-oxalic-acid-and-hot-water-treatments-on-postharvest-quality-of-rambutan-nephelium-lappaceum-l-cv-anak-sekolah-under-modified-atmosphere-packaging
#15
Ahmad Faiz Ahmad Hafiz, Yeoh Wei Keat, Asgar Ali
The shelf life of rambutan is often limited due to rapid water loss from the spinterns and browning of the pericarp. An integrated approach, which combined hot water treatment (HWT) (56 °C for 1 min), oxalic acid (OA) dip (10% for 10 min) and modified atmosphere packaging (MAP), was used to study their effectiveness on the quality of rambutan during storage (10 °C, 90-95% relative humidity). Significant differences were observed in rambutan quality with the combination of MAP + HWT + OA after 20 days of storage...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720800/itraq-based-quantitative-proteomic-analysis-reveals-alterations-in-the-metabolism-of-actinidia-arguta
#16
Miaomiao Lin, Jinbao Fang, Xiujuan Qi, Yukuo Li, Jinyong Chen, Leiming Sun, Yunpeng Zhong
Actinidia arguta 'Tianyuanhong' is a new kiwifruit variety with an all-red pericarp and pulp, in contrast to the all-green pulp of A. arguta 'Yongfengyihao'. Transcriptome profile analysis of fruit color has been reported, however, the metabolic mechanisms producing red flesh remain unknown, and it is unclear why the pulp of 'Tianyuanhong' is red rather than green. Herein, we identified differences between the proteomes of two A. arguta cultivars with different fruit color by using iTRAQ-based quantitative proteomic methods during the stage of color change...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702654/direct-and-indirect-measurements-of-enhanced-phenolic-bioavailability-from-litchi-pericarp-procyanidins-by-lactobacillus-casei-01
#17
Shuyi Li, Xiaopeng Li, Avi Shpigelman, Jose M Lorenzo, Domenico Montesano, Francisco J Barba
Litchi pericarp procyanidins (LPP) are dietary supplements with high antioxidant activity, but poor oral bioavailability and efficacy. Lactobacillus casei (L. casei-01) can transform flavan-3-ols from litchi pericarp and increase their antioxidant ability; thus, L. casei-01 with LPP was administered to rats for four and eight weeks to study the effect of such a combination on metabolic parameters and on phase II metabolism and detoxification pathways in the liver as an indirect measure for phenolic bioavailability...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28700827/compatible-rhizosphere-competent-microbial-consortium-adds-value-to-the-nutritional-quality-in-edible-parts-of-chickpea
#18
Sudheer K Yadav, Surendra Singh, Harikesh B Singh, Birinchi K Sarma
Chickpea is used as a high-energy and protein source in diets of humans and livestock. Moreover, chickpea straw can be used as alternative of forage in ruminant diets. The present study evaluates the effect of beneficial microbial inoculation on enhancing the nutritional values in edible parts of chickpea. Two rhizosphere-competent compatible microbes (Pseudomonas fluorescens OKC and Trichoderma asperellum T42) were selected and applied to seeds either individually or in consortium before sowing. Chickpea seeds treated with the microbes showed enhanced plant growth [88...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28700755/the-dead-seed-coat-functions-as-a-long-term-storage-for-active-hydrolytic-enzymes
#19
Buzi Raviv, Lusine Aghajanyan, Gila Granot, Vardit Makover, Omer Frenkel, Yitzchak Gutterman, Gideon Grafi
Seed development culminates in programmed cell death (PCD) and hardening of organs enclosing the embryo (e.g., pericarp, seed coat) providing essentially a physical shield for protection during storage in the soil. We examined the proposal that dead organs enclosing embryos are unique entities that store and release upon hydration active proteins that might increase seed persistence in soil, germination and seedling establishment. Proteome analyses of dead seed coats of Brassicaceae species revealed hundreds of proteins being stored in the seed coat and released upon hydration, many are stress-associated proteins such as nucleases, proteases and chitinases...
2017: PloS One
https://www.readbyqxmd.com/read/28675968/effects-of-a-high-o2-dynamic-controlled-atmosphere-technology-on-the-browning-of-postharvest-white-mushroom-agaricus-bisporus-in-relation-to-energy-metabolism
#20
Ling Li, Han Sun, Hiroaki Kitazawa, Xiangyou Wang
Browning is one of the main problems in senescence of mushrooms, and it is also one of the most important attributes accounting for the loss of the quality and reduction in market value. In order to study the relationship between the energy metabolism and the browning of white mushroom under high O2 dynamic-controlled atmosphere (HO-DCA), mushrooms were stored in 100% O2 (SCA1), 80% O2 + 20% CO2 (SCA2), 100% O2 for three days and then transferred into the treatment of 80% O2 + 20% CO2 (HO-DCA) at 2 ± 1 ℃ and air as control...
July 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
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