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https://www.readbyqxmd.com/read/28641010/alpha-mangostin-reverses-multidrug-resistance-by-attenuating-the-function-of-the-multidrug-resistance-linked-abcg2-transporter
#1
Chung-Pu Wu, Sung-Han Hsiao, Megumi Murakami, Yu-Jen Lu, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh V Ambudkar, Yu-Shan Wu
The ATP-binding cassette (ABC) drug transporter ABCG2 can actively efflux a wide variety of chemotherapeutic agents out of cancer cells and subsequently reduce the intracellular accumulation of these drugs. Therefore, the overexpression of ABCG2 often contributes to the development of multidrug resistance (MDR) in cancer cells, which is one of the major obstacles to successful cancer chemotherapy. Moreover, ABCG2 is highly expressed in various tissues including the intestine and blood-brain barrier (BBB), limiting the absorption and bioavailability of many therapeutic agents...
June 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28624092/study-on-the-effects-of-wheat-bran-incorporation-on-water-mobility-and-biopolymer-behavior-during-bread-making-and-storage-using-time-domain-1-h-nmr-relaxometry
#2
S Hemdane, P J Jacobs, G M Bosmans, J Verspreet, J A Delcour, C M Courtin
Water binding is suggested to be key in the deleterious effect of wheat bran on bread quality. This study investigates water mobility and biopolymer behavior during bran-rich bread making and storage, using (1)H NMR. Coarse, ground, and pericarp-enriched bran were incorporated in bread dough, and their impact on freshly baked and stored bread properties was assessed. Compared to wheat flour control dough, bran incorporation resulted in a progressive immobilization of water during dough resting, which could be linked to changes in evolution of dough height during fermentation and oven rise...
December 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28624091/study-of-biopolymer-mobility-and-water-dynamics-in-wheat-bran-using-time-domain-1-h-nmr-relaxometry
#3
S Hemdane, P J Jacobs, G M Bosmans, J Verspreet, J A Delcour, C M Courtin
In this study, the molecular mobility of water and biopolymers in coarse, ground, and pericarp-enriched (PE) wheat bran and refined flour was investigated using time-domain proton nuclear magnetic resonance relaxometry, and related to their hydration properties. Several specific proton populations were present in the bran samples but not in flour. These populations were mainly assigned to protons of bran-related compounds such as arabinoxylan, cellulose, and lipids. All bran samples showed similar proton distributions at a 44% moisture level, although the chemical composition of coarse/ground bran and PE bran differed...
December 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28602011/differences-in-the-fruit-structure-and-the-location-and-content-of-bioactive-substances-in-viburnum-opulus-and-viburnum-lantana-fruits
#4
Agata Konarska, Marcin Domaciuk
Many Viburnum species are popular ornamental shrubs and, simultaneously, highly valued medicinal plants as a source of many bioactive compounds, including antioxidants. Viburnum bark, flowers, and fruits are widely used in traditional and folk medicine, and the fruits of some species are used as cooking ingredients. The knowledge of the microstructure of Viburnum fruits and the accumulation sites of bioactive substances in these organs is rather poor. Comparative analyses of the microstructure of ripe Viburnum opulus and Viburnum lantana drupes were carried out using light, scanning, and transmission electron microscopes...
June 10, 2017: Protoplasma
https://www.readbyqxmd.com/read/28592557/comparative-mapping-of-seed-dormancy-loci-between-tropical-and-temperate-ecotypes-of-weedy-rice-oryza-sativa-l
#5
Lihua Zhang, Jieqiong Luo, Michael E Foley, Xing-You Gu
Genotypic variation at multiple loci for seed dormancy (SD) contributes to plant adaptation to diverse ecosystems. Weedy rice (Oryza sativa) was used as a model to address the similarity of SD genes between distinct ecotypes. A total of 12 quantitative trait loci for SD were identified in a primary and two advanced backcross populations derived from a temperate ecotype of weedy rice (34.3°N Lat.). Nine (75%) of the 12 loci were mapped to the same positions as those identified from a tropical ecotype of weedy rice (7...
June 7, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28587348/hepatoprotective-effects-of-litchi-litchi-chinensis-procyanidin-a2-on-carbon-tetrachloride-induced-liver-injury-in-icr-mice
#6
Lih-Geeng Chen, Cheng-Wei Chang, Jwu-Guh Tsay, Brian Bor-Chun Weng
Drug tolerance, lacking liver regenerative activity and inconclusive inhibition of steatosis and cirrhosis by silymarin treatment during chronic liver injury have increased the demand for novel alternative or synergistic treatments for liver damage. Litchi fruit is abundant in polyphenolic compounds and is used in traditional Chinese medicine for treatments that include the strengthening of hepatic and pancreatic functions. Unique polyphenolic compounds obtained from litchi pericarp extract (LPE) were studied in vitro and in vivo for hepatoprotection...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28582759/%C3%AE-mangostin-inhibits-dmba-tpa-induced-skin-cancer-through-inhibiting-inflammation-and-promoting-autophagy-and-apoptosis-by-regulating-pi3k-akt-mtor-signaling-pathway-in-mice
#7
Fei Wang, Hongxia Ma, Zhaoguo Liu, Wei Huang, Xiaojing Xu, Xuemei Zhang
Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality, the treatment progress of which remains slow though. Therefore, studies identifying anti-skin cancer agents that are innocuous are urgently needed. α-Mangostin, a natural product isolated from the pericarp of mangosteen fruit, has potent anti-cancer activity. However, its role in skin cancer remains unclear. The aim of this study was to evaluate the treatment effect of α-mangostin on skin tumorigenesis induced by 9,10-dimethylbenz[a]anthracene (DMBA)/TPA in mice and the potential mechanism...
June 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28574305/growth-modeling-of-aspergillus-niger-strains-isolated-from-citrus-fruit-as-a-function-of-temperature-on-a-synthetic-medium-from-lime-citrus-latifolia-t-pericarp
#8
T Sandoval-Contreras, S Marín, A Villarruel-López, A Gschaedler, L Garrido-Sánchez, F Ascencio
Molds are responsible for postharvest spoilage of citrus fruits. The objective of this study was to evaluate the effect of temperature on growth rate and the time to visible growth of Aspergillus niger strains isolated from citrus fruits. The growth of these strains was studied on agar lime medium (AL) at different temperatures, and growth rate was estimated using the Baranyi and Roberts model (Int. J. Food Microbiol. 23:277-294, 1994). The Rosso et al. cardinal model with inflexion (L. Rosso, J. R. Lobry, S...
June 2, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28574181/increased-pericarp-cell-length-underlies-a-major-quantitative-trait-locus-for-grain-weight-in-hexaploid-wheat
#9
Jemima Brinton, James Simmonds, Francesca Minter, Michelle Leverington-Waite, John Snape, Cristobal Uauy
Crop yields must increase to address food insecurity. Grain weight, determined by grain length and width, is an important yield component, but our understanding of the underlying genes and mechanisms is limited. We used genetic mapping and near isogenic lines (NILs) to identify, validate and fine-map a major quantitative trait locus (QTL) on wheat chromosome 5A associated with grain weight. Detailed phenotypic characterisation of developing and mature grains from the NILs was performed. We identified a stable and robust QTL associated with a 6...
June 2, 2017: New Phytologist
https://www.readbyqxmd.com/read/28558875/characterization-and-quantitation-of-aristolochic-acid-analogs-in-different-parts-of-aristolochiae-fructus-using-uhplc-q-tof-ms-and-uhplc-qqq-ms
#10
Wen-Wen Mao, Wen Gao, Zhi-Tao Liang, Ping Li, Zhong-Zhen Zhao, Hui-Jun Li
Aristolochiae Fructus, a Chinese herbal medicine derived from the fruit of Aristolochia contorta Bge., contains nephrotoxic aristolochic acid analogues (AAAs). According to ancient medical texts, various medicinal parts of the fruit of A. contorta were ever used. In order to reveal which part could be safely and effectively used, it is necessary to analyze the chemical profiles of different medicinal parts. Herein we compared the chemical compositions and determined aristolochic acid I (AA-I) and aristolochic acid II (AA-II) in the four parts viz...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28529883/smrt-sequencing-data-for-garcinia-mangostana-l-variety-mesta
#11
Mohd Razik Midin, Kok-Keong Loke, Maria Madon, Mohd Shukor Nordin, Hoe-Han Goh, Normah Mohd Noor
The "Queen of Fruits" mangosteen (Garcinia mangostana L.) produces commercially important fruits with desirable taste of flesh and pericarp rich in xanthones with medicinal properties. To date, only limited knowledge is available on the cytogenetics and genome sequences of a common variety of mangosteen (Abu Bakar et al., 2016 [1]). Here, we report the first single-molecule real-time (SMRT) sequencing data from whole genome sequencing of mangosteen of Mesta variety. Raw reads of the SMRT sequencing project can be obtained from SRA database with the accession numbers SRX2718652 until SRX2718659...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28516035/dna-shotgun-sequencing-analysis-of-garcinia-mangostana-l-variety-mesta
#12
Syuhaidah Abu Bakar, Suresh Kumar, Kok-Keong Loke, Hoe-Han Goh, Normah Mohd Noor
Mangosteen (Garcinia mangostana Linn.) is an ultra-tropical tree characterized by its unique dark purple fruits with white flesh. The xanthone-rich purple pericarp tissue contains valuable compounds with medicinal properties. Following previously reported genome sequencing of a common variety of mangosteen [1], we performed another whole genome sequencing of a commercially popular variety of this fruit species (var. Mesta) for comparative analysis of its genome composition. Raw reads of the DNA sequencing project were deposited to SRA database with the accession number SRX2709728...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28509349/isolation-of-tissues-and-preservation-of-rna-from-intact-germinated-barley-grain
#13
Natalie S Betts, Oliver Berkowitz, Ruijie Liu, Helen M Collins, Birgitte Skadhauge, Christoph Dockter, Rachel A Burton, James Whelan, Geoffrey B Fincher
Isolated barley (Hordeum vulgare L.) aleurone layers have been widely used as a model system for studying gene expression and hormonal regulation in germinating cereal grains. A serious technological limitation of this approach has been the inability to confidently extrapolate conclusions obtained from isolated tissues back to the whole grain, where the co-location of several living and non-living tissues results in complex tissue-tissue interactions and regulatory pathways coordinated across the multiple tissues...
May 16, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28505165/determination-of-fruit-maturity-and-its-prediction-model-based-on-the-pericarp-index-of-absorbance-difference-iad-for-peaches
#14
Binbin Zhang, Bin Peng, Chunhua Zhang, Zhizhong Song, Ruijuan Ma
Harvest maturity is closely related to peach fruit quality and has a very important effect on the fresh fruit market. Unfortunately, at present, it is difficult to determine the maturity level of peach fruits by artificial methods. The objectives of this study were to develop quadratic polynomial regression models using near-infrared spectroscopy that could determine the peel color difference, fruit firmness, soluble solids content (SSC), soluble sugar, organic acid components, and their relationships with the absorbance of chlorophyll (index of absorbance difference, IAD) in late maturing 'Xiahui 8' peach and 'Xiaguang' nectarine fruits...
2017: PloS One
https://www.readbyqxmd.com/read/28490122/anthocyanin-condensed-forms-do-not-affect-color-or-chemical-stability-of-purple-corn-pericarp-extracts-stored-under-different-phs
#15
Diego Luna-Vital, Qian Li, Leslie West, Megan West, Elvira Gonzalez de Mejia
Purple corn is rich in anthocyanins, some of which are condensed with flavanols. The aim was to determine the impact of anthocyanin condensed forms extracted from purple corn pericarp on color and chemical stability at different pHs compared with the complete extract, and an extract without condensed forms. Extracts were dissolved at pH values ranging from 2.0 to 6.0 and stored for 12weeks at 22°C. Color stability of anthocyanins decreased as the pH increased. Slight color differences were observed throughout time at pH 2 (ΔE from 0...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28486974/cell-separation-in-kiwifruit-without-development-of-a-specialised-detachment-zone
#16
Roneel Prakash, Ian C Hallett, Sally F Wong, Sarah L Johnston, Erin M O'Donoghue, Peter A McAtee, Alan G Seal, Ross G Atkinson, Roswitha Schröder
BACKGROUND: Unlike in abscission or dehiscence, fruit of kiwifruit Actinidia eriantha develop the ability for peel detachment when they are ripe and soft in the absence of a morphologically identifiable abscission zone. Two closely-related genotypes with contrasting detachment behaviour have been identified. The 'good-peeling' genotype has detachment with clean debonding of cells, and a peel tissue that does not tear. The 'poor-peeling' genotype has poor detachability, with cells that rupture upon debonding, and peel tissue that fragments easily...
May 10, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28471298/optimized-ultra-high-pressure-assisted-extraction-of-procyanidins-from-lychee-pericarp-improves-the-antioxidant-activity-of-extracts
#17
Ruifen Zhang, Dongxiao Su, Fangli Hou, Lei Liu, Fei Huang, Lihong Dong, Yuanyuan Deng, Yan Zhang, Zhencheng Wei, Mingwei Zhang
To establish optimal ultra-high-pressure (UHP)-assisted extraction conditions for procyanidins from lychee pericarp, a response surface analysis method with four factors and three levels was adopted. The optimum conditions were as follows: 295 MPa pressure, 13 min pressure holding time, 16.0 mL/g liquid-to-solid ratio, and 70% ethanol concentration. Compared with conventional ethanol extraction and ultrasonic-assisted extraction methods, the yields of the total procyanidins, flavonoids, and phenolics extracted using the UHP process were significantly increased; consequently, the oxygen radical absorbance capacity and cellular antioxidant activity of UHP-assisted lychee pericarp extracts were substantially enhanced...
May 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28456120/distinct-organ-specific-and-temporal-expression-profiles-of-auxin-related-genes-during-mango-fruitlet-drop
#18
Youlia Denisov, Shani Glick, Tali Zviran, Mazal Ish-Shalom, Adolfo Levin, Adi Faigenboim, Yuval Cohen, Vered Irihimovitch
In mango, fruitlet abscission initiates with a decrease in polar auxin transport through the abscission zone (AZ), triggered by ethylene. To explore the molecular components affecting this process, we initially conducted experiments with developing fruitlet explants in which fruitlet drop was induced by ethephon, and monitored the expression patterns of distinct indole-3-acetic acid (IAA)-related genes, comparing control vs. ethephon-treated pericarp and AZ profiles. Over the examined time period (48 h), the accumulation of MiPIN1 and MiLAX2 IAA-efflux and influx genes decreased in both control and treated tissues...
June 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28455132/garcinia-mangostana-pericarp-extract-protects-against-oxidative-stress-and-cardiovascular-remodeling-via-suppression-of-p47-phox-and-inos-in-nitric-oxide-deficient-rats
#19
Pattanapong Boonprom, Orachorn Boonla, Kanokporn Chayaburakul, Jariya Umka Welbat, Patchareewan Pannangpetch, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Poungrat Pakdeechote, Parichat Prachaney
N(ω)-Nitro-l-arginine methyl ester (l-NAME)-induced hypertension and cardiovascular remodeling are associated with oxidative stress and inflammation. Garcinia mangostana Linn., has been reported to have antioxidant and anti-inflammatory properties. This study investigated whether G. mangostana pericarp extract (GME) could prevent l-NAME-induced hemodynamic alterations, cardiovascular remodeling, oxidative stress and inflammation in rats. Male Sprague-Dawley rats were given 40mg/kg/day of l-NAME in drinking water to induce hypertension, and were simultaneously treated with GME at a dose of 200mg/kg/day...
April 26, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28450015/a-comparative-study-of-anthocyanin-distribution-in-purple-and-blue-corn-coproducts-from-three-conventional-fractionation-processes
#20
Qian Li, Pavel Somavat, Vijay Singh, Laura Chatham, Elvira Gonzalez de Mejia
The aim was to compare the distribution of ANCs in purple and blue corn coproducts from three conventional corn fractionation processes and linking ANC partitioning in different coproducts to corn kernel phenotype. Total monomeric anthocyanin (TA) from purple corn extract was 4933.1±43.4mg cyanidin-3-glucoside equivalent per kg dry corn, 10 times more than blue corn. In dry milled purple corn, maximum ANCs were present in the pericarp (45.9% of total ANCs) and in wet-milling they were concentrated in steeping water (79...
September 15, 2017: Food Chemistry
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