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https://www.readbyqxmd.com/read/28813591/on-surface-oligomerization-of-self-terminating-molecular-chains-for-the-design-of-spintronic-devices
#1
Emil Sierda, Mikel Abadia, Jens Brede, Micha Elsebach, Bernhard Bugenhagen, Marc Heinrich Prosenc, Maciej Bazarnik, Roland Wiesendanger
Molecular spintronics is currently attracting a lot of attention due to its great advantages over traditional electronics. A variety of self-assembled molecule-based devices are under development, but studies regarding the reliability of the growth-process remain rare. Here, we present a method to control the length of molecular spintronic chains and to make their terminations chemically inert, thereby suppressing uncontrolled coupling to surface defects. The temperature evolution of chain formation was followed by X-ray photoelectron spectroscopy, to determine optimal growth conditions...
August 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28813526/mtor-has-a-developmental-stage-specific-role-in-mitochondrial-fitness-independent-of-conventional-mtorc1-and-mtorc2-and-the-kinase-activity
#2
Khalid W Kalim, Shuangmin Zhang, Xiaoyi Chen, Yuan Li, Jun-Qi Yang, Yi Zheng, Fukun Guo
The mammalian target of rapamycin (mTOR), present in mTOR complex 1 (mTORC1) and mTORC2, is a serine/threonine kinase that integrates nutrients, growth factors, and cellular energy status to control protein synthesis, cell growth, survival and metabolism. However, it remains elusive whether mTOR plays a developmental stage-specific role in tissue development and whether mTOR can function independent of its complexes and kinase activity. In this study, by inducible genetic manipulation approach, we investigated the role of mTOR and its dependence on mTOR complexes and kinase activity in mitochondrial fitness of early, progenitor stage (lineage-negative; Lin-) versus later, lineage-committed stage (lineage-positive; Lin+) of hematopoietic cells...
2017: PloS One
https://www.readbyqxmd.com/read/28812164/efficacy-of-fractional-lasers-in-treating-alopecia-a-literature-review
#3
Marina Perper, Adam S Aldahan, Rachel A Fayne, Christopher P Emerson, Keyvan Nouri
Hair loss stemming from different types of alopecia, such as androgenic alopecia and alopecia areata, negatively affects over half the population and, in many circumstances, causes serious psychosocial distress. Current treatment options for alopecia, such as minoxidil, anthralin, and intralesional corticosteroids, vary efficacy and side effect profiles. It is known that low-level laser/light therapies (LLLT), or photobiomodulations, such as the US FDA-cleared HairMax Lasercomb®, He-Ne laser, and excimer laser, are relatively affordable, user-friendly, safe, and effective forms of treatment for hair loss...
August 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28811996/experimental-method-and-statistical-analysis-to-fit-tumor-growth-model-using-spect-ct-imaging-a-preclinical-study
#4
Ivan Hidrovo, Joyoni Dey, Megan E Chesal, Dmytro Shumilov, Narayan Bhusal, J Michael Mathis
BACKGROUND: Over the last decade, several theoretical tumor-models have been developed to describe tumor growth. Oncology imaging is performed using various modalities including computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and fluorodeoxyglucose-positron emission tomography (FDG-PET). Our goal is to extract useful, otherwise hidden, quantitative biophysical parameters (such as growth-rate, tumor-necrotic-factor, etc.) from these serial images of tumors by fitting mathematical models to images...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811889/genome-size-in-arthropods-different-roles-of-phylogeny-habitat-and-life-history-in-insects-and-crustaceans
#5
Kristian Alfsnes, Hans Petter Leinaas, Dag Olav Hessen
Despite the major role of genome size for physiology, ecology, and evolution, there is still mixed evidence with regard to proximate and ultimate drivers. The main causes of large genome size are proliferation of noncoding elements and/or duplication events. The relative role and interplay between these proximate causes and the evolutionary patterns shaped by phylogeny, life history traits or environment are largely unknown for the arthropods. Genome size shows a tremendous variability in this group, and it has a major impact on a range of fitness-related parameters such as growth, metabolism, life history traits, and for many species also body size...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811480/formation-pathways-of-mesoporous-silica-nanoparticles-with-dodecagonal-tiling
#6
Yao Sun, Kai Ma, Teresa Kao, Katherine A Spoth, Hiroaki Sai, Duhan Zhang, Lena F Kourkoutis, Veit Elser, Ulrich Wiesner
Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-directed mesoporous silica nanoparticle structures, including dodecagonal quasicrystalline nanoparticles, as a function of micelle pore expander concentration or stirring rate. We demonstrate that the early formation stages of dodecagonal quasicrystalline mesoporous silica nanoparticles can be preserved, where precise control of mesoporous silica nanoparticle size down to <30 nm facilitates comparison between mesoporous silica nanoparticles and simulated single-particle growth trajectories beginning with a single tiling unit...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811214/semi-empirical-modeling-of-microalgae-photosynthesis-in-different-acclimation-states-application-to-n-gaditana
#7
Andrea Bernardi, Andreas Nikolaou, Andrea Meneghesso, Benoît Chachuat, Tomas Morosinotto, Fabrizio Bezzo
The development of mathematical models capable of accurate predictions of the photosynthetic productivity of microalgae under variable light conditions is paramount to the development of large-scale production systems. The process of photoacclimation is particularly important in outdoor cultivation systems, whereby seasonal variation of the light irradiance can greatly influence microalgae growth. This paper presents a dynamic model that captures the effect of photoacclimation on the photosynthetic production...
August 12, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28810704/yeast-kch1-and-kch2-membrane-proteins-play-a-pleiotropic-role-in-membrane-potential-establishment-and-monovalent-cation-homeostasis-regulation
#8
Kristina Felcmanova, Petra Neveceralova, Hana Sychrova, Olga Zimmermannova
The Kch1 and Kch2 plasma-membrane proteins were identified in Saccharomyces cerevisiae as being essential for the activation of a high-affinity Ca2+ influx system. We searched for Kch proteins roles in the maintenance of cation homeostasis and tested the effect of kch1 and/or kch2 deletions on various physiological parameters. Compared to wild-type, kch1 kch2 mutant cells were smaller, relatively hyperpolarised, grew better under limited K+ conditions and exhibited altered growth in the presence of monovalent cations...
August 1, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28810223/effects-of-an-allelochemical-in-phaeodactylum-tricornutum-filtrate-on-heterosigma-akashiwo-morphological-physiological-and-growth-effects
#9
Rui Wang, Qiaona Xue, Jiangtao Wang, Liju Tan, Qingchun Zhang, Yue Zhao, Donald M Anderson
The effects of an allelochemical extracted from the culture filtrate of diatom Phaeodactylum tricornutum on the raphidophyte Heterosigma akashiwo were investigated using a series of morphological, physiological and biochemical characters. Growth experiments showed that H. akashiwo was significantly inhibited immediately after exposure to the allelochemical, with many cells rapidly dying and lysing based on microscopic observation. The effects of the allelochemical on the surviving cells were explored using Scanning Electron Microscopy (SEM) and Flow cytometry (FCM), the latter by examination of a suite of physiological parameters (membrane integrity, esterase activity, chlorophyll-a content, membrane potential)...
August 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28809955/biodegradation-of-diuron-by-an-endophytic-fungus-neurospora-intermedia-dp8-1-isolated-from-sugarcane-and-its-potential-for-remediating-diuron-contaminated-soils
#10
Yanhui Wang, Honghong Li, Guojun Feng, Liangwei Du, Dongqiang Zeng
A diuron-degrading endophyte DP8-1 was isolated from sugarcane root grown in diuron-treated soil in the present study. The endophyte was identified as Neurospora intermedia based on the morphological characteristics and sequence analysis. The fermentation parameters including temperature, pH, inoculation size, carbon source, and initial diuron concentration were also investigated for the optimization of degradation efficiency. The results indicated that strain DP8-1 was capable of degrading up to 99% diuron within 3 days under the optimal degrading condition...
2017: PloS One
https://www.readbyqxmd.com/read/28809005/resazurin-live-cell-assay-setup-and-fine-tuning-for-reliable-cytotoxicity-results
#11
José Á Rodríguez-Corrales, Jatinder S Josan
In vitro cytotoxicity tests allow for fast and inexpensive screening of drug efficacy prior to in vivo studies. The resazurin assay (commercialized as Alamar Blue(®)) has been extensively utilized for this purpose in 2D and 3D cell cultures, and high-throughput screening. However, improper or lack of assay validation can generate unreliable results and limit reproducibility. Herein, we report a detailed protocol for the optimization of the resazurin assay to determine relevant analytical (limits of detection, quantification, and linear range) and biological (growth kinetics) parameters, and, thus, provide accurate cytotoxicity results...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808873/elevated-hu-antigen-receptor-hur-expression-is-associated-with-tumor-aggressiveness-and-poor-prognosis-but-not-with-cox-2-expression-in-invasive-breast-carcinoma-patients
#12
Constantinos Giaginis, Anastasia Sampani, Iolly Kotta-Loizou, Ioanna Giannopoulou, Eugene Danas, Ekaterini Politi, Gerasimos Tsourouflis, Gregorios Kouraklis, Efstratios Patsouris, Antonios Keramopoulos, Lydia Nakopoulou, Stamatios Theocharis
Hu-antigen R (HuR), a RNA-binding protein, is considered to play a crucial role in tumor development and progression by stabilizing or regulating a group of cellular mRNAs of cancer-related genes, such as cyclooxygenase-2 (COX-2). The present study aimed to evaluate the clinical significance of HuR and COX-2 expression in invasive breast carcinoma. HuR and COX-2 protein expression was assessed immunohistochemically on paraffin-embedded breast cancer tissue sections obtained from 121 patients and was statistically analyzed with clinicopathological parameters, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), as well as with tumor cells' proliferative capacity and overall and disease-free patients' survival...
August 14, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28808402/role-of-adiantum-philippense-l-on-glucose-uptake-in-isolated-pancreatic-cells-and-inhibition-of-adipocyte-differentiation-in-3t3-l1-cell-line
#13
Tania Paul, Kishori G Apte, Pradeep B Parab, Biswadeep Das
BACKGROUND: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. OBJECTIVE: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808259/combination-of-chemical-fingerprint-and-bioactivity-evaluation-to-explore-the-antibacterial-components-of-salvia-miltiorrhizae
#14
Wei-Jun Kong, Shan-Shan Zhang, Yan-Ling Zhao, Ming-Quan Wu, Ping Chen, Xiao-Ru Wu, Xin-Ping Ma, Wei-Ying Guo, Mei-Hua Yang
The aim of this study was to explore the possible antibacterial components of Salvia miltiorrhizae on Pseudomonas aeruginosa using a combination of chemical fingerprint and bioactivity evaluation. The chemical fingerprints of 32 batches of S. miltiorrhizae samples from different sources were developed using high-performance liquid chromatography with diode array detection, and then were evaluated by similarity analysis and hierarchical clustering analysis. Anti-P. aeruginosa activity was determined by microcalorimetry...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808229/bioenergy-application-of-dunaliella-salina-sa-134-grown-at-various-salinity-levels-for-lipid-production
#15
Rajper Aftab Ahmed, Meilin He, Rajper Asma Aftab, Shiyan Zheng, Mostafa Nagi, Ramadan Bakri, Changhai Wang
The biofuels are receiving considerable attention as a substitute for petro diesel. For microalgae, the cell density or biomass and lipid contents are key components for biodiesel production. This study was conducted to develop favorable culture conditions for Dunaliella salina to maximize its biomass and lipid accumulation. The effect of salinity (0.5 to 2.5 M NaCl) on the cell population, biochemical composition, and lipid output of Dunaliella salina was examined under a controlled environment for 21 days...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808126/growth-and-stress-induced-pasta-kinase-phosphorylation-in-enterococcus-faecalis
#16
Benjamin D Labbe, Christopher J Kristich
Transmembrane Ser/Thr kinases containing extracellular PASTA domains are ubiquitous among Actinobacteria and Firmicutes. Such PASTA kinases regulate critical processes including antibiotic resistance, cell division, toxin production, virulence, and are essential for viability in certain organisms. Based on in vitro studies with purified extra- and intracellular fragments of PASTA kinases, a model for signaling has been proposed, in which the extracellular PASTA domains bind as-yet-undefined ligands - typically thought to be peptidoglycan, or fragments thereof - to drive kinase dimerization, which leads to enhanced kinase autophosphorylation and enhanced phosphorylation of substrates...
August 14, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28807649/effects-of-dietary-tenebrio-molitor-meal-on-the-growth-performance-immune-response-and-disease-resistance-of-yellow-catfish-pelteobagrus-fulvidraco
#17
Jingzhi Su, Yulong Gong, Shenping Cao, Fei Lu, Dong Han, Haokun Liu, Junyan Jin, Yunxia Yang, Xiaoming Zhu, Shouqi Xie
This study evaluated the influence of diets containing mealworm (Tenebrio molitor) meal in partial substitution of fishmeal on growth performance and immune responses of juvenile yellow catfish (Pelteobagrus fulvidraco). Four diets were formulated to contain 0 (the control diet), 9, 18 and 27 g mealworm meal per 100 g diet with 0%, 25%, 50% and 75% of fishmeal replacement, respectively. Yellow catfish were randomly divided into 4 groups with 3 replicates in each group. The fish in each group were fed with one of the four experimental diets for 5 weeks...
August 11, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28807479/multifactorial-analyses-revealed-optimal-aquaculture-modalities-improving-husbandry-fitness-without-clear-effect-on-stress-and-immune-status-of-pikeperch-sander-lucioperca
#18
Sébastien Baekelandt, Baptiste Redivo, Syaghalirwa N M Mandiki, Thibaut Bournonville, Alexis Houndji, Benoît Bernard, Najlae El Kertaoui, Mélodie Schmitz, Pascal Fontaine, Jean-Noël Gardeur, Yannick Ledoré, Patrick Kestemont
High mortality and impairment in growth rate during pikeperch (Sander lucioperca) ongrowing are among the major bottlenecks for its development in aquaculture. These failures may be related to high stress responsiveness since the rearing conditions are not yet optimized for this species. The objectives were to characterize the stress and immunological responses of pikeperch to major aquaculture modalities, and to identify the optimal aquaculture conditions for improving its welfare status. In a screening experiment, eight factors considered as relevant for the welfare of pikeperch were compared in two modalities using a fractional multifactorial design (2(8-4))...
August 11, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28806499/hibernating-little-pocket-mice-show-few-seasonal-changes-in-bone-properties
#19
Noellyn Pineda, Marjorie Owen, Claire Tucker, Sam Wojda, Stanley Kitchen, Hal Black, Seth Donahue
Periods of disuse or physical inactivity increase bone porosity and decrease bone mineral density, resulting in a loss of bone mechanical competence in many animals. Although large hibernators like bears and marmots prevent bone loss during hibernation, despite long periods of physical inactivity, some small hibernators do lose bone during hibernation. Little pocket mice (Perognathus longimembris) remain underground during winter hibernation and undergo bouts of torpor and interbout arousals, but the torpor bout duration is shorter than other rodent hibernators...
August 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28806419/effects-of-short-term-dry-immersion-on-bone-remodeling-markers-insulin-and-adipokines
#20
Marie-Thérèse Linossier, Liubov E Amirova, Mireille Thomas, Myriam Normand, Marie-Pierre Bareille, Guillemette Gauquelin-Koch, Arnaud Beck, Marie-Claude Costes-Salon, Christine Bonneau, Claude Gharib, Marc-Antoine Custaud, Laurence Vico
BACKGROUND: Dry immersion (DI), a ground-based model of microgravity previously used in Russia, has been recently implemented in France. The aim of this study was to analyze early events in a short-term DI model in which all conditions are met to investigate who is first challenged from osteo- or adipo-kines and to what extent they are associated to insulin-regulating hormones. METHODS: Twelve healthy men were submitted to a 3-day DI. Fasting blood was collected during pre-immersion phase for the determination of the baseline data collection (BDC), daily during DI (DI24h, DI48H and DI72h), then after recovery (R+3h and R+24h)...
2017: PloS One
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