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https://www.readbyqxmd.com/read/29334314/on-the-intrinsic-constraint-of-bacterial-growth-rate-m-tuberculosis-s-view-of-the-protein-translation-capacity
#1
Manlu Zhu, Xiongfeng Dai
In nature, the maximal growth rates vary widely among different bacteria species. Fast-growing bacteria species such as Escherichia coli can have a shortest generation time of 20 min. Slow-growing bacteria species are perhaps best known for Mycobacterium tuberculosis, a human pathogen with a generation time being no less than 16 h. Despite of the significant progress made on understanding the pathogenesis of M. tuberculosis, we know little on the origin of its intriguingly slow growth. From a global view, the intrinsic constraint of the maximal growth rate of bacteria remains to be a fundamental question in microbiology...
January 15, 2018: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/29334250/estimation-of-a-latent-variable-regression-growth-curve-model-for-individuals-cross-classified-by-clusters
#2
Audrey J Leroux, S Natasha Beretvas
The cross-classified multiple membership latent variable regression (CCMM-LVR) model is a recent extension to the three-level latent variable regression (HM3-LVR) model which can be utilized for longitudinal data that contains individuals who changed clusters over time (for instance, student mobility across schools). The HM3-LVR model can include the initial status on growth effect as varying across those clusters and allows testing of more flexible hypotheses about the influence of initial status on growth and of factors that might impact that relationship, but only in the presence of pure clustering of participants within higher-level units...
January 15, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29333048/astaxanthin-ameliorates-hepatic-damage-and-oxidative-stress-in-carbon-tetrachloride-administered-rats
#3
Md Ariful Islam, Md Abdullah Al Mamun, Md Faruk, Md Tauhid Ul Islam, Md Mizanur Rahman, Mohammad Nazmul Alam, A F M Towheedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Background: Astaxanthin is of carotenoids group which possess strong antioxidant properties. The present study was conducted to evaluate the hepatoprotective effects of astaxanthin in carbon tetrachloride (CCl4)-treated rats. Materials and Methods: Female Long-Evans rats were administered with CCl4 orally (1 ml/kg) twice a week for 2 weeks and were treated with astaxanthin (10 mg/kg) every day for 2 weeks. Blood plasma samples were isolated from each group and were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase activities...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29333017/correlation-of-hormone-receptor-and-human-epidermal-growth-factor-receptor-2-neu-expression-in-breast-cancer-with-various-clinicopathologic-factors
#4
Cherry Bansal, Aarti Sharma, Mukta Pujani, Meenu Pujani, Kiran Lata Sharma, A N Srivastava, U S Singh
Background: A significant development in the breast carcinoma management is the correlation between the presence of hormone receptors in the tumor and response to hormonal therapy and chemotherapy. Human epidermal growth factor receptor-2/neu (Her-2/neu) overexpression also serves as a very useful parameter to predict response to herceptin. Aim of Study: The study was conducted to correlate immunohistochemical expression of markers such as estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu with various clinicopathologic parameters...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332996/optimal-population-and-exhaustible-resource-constraints
#5
Nicholas Lawson, Dean Spears
A large literature considers the optimal size and growth rate of the human population, trading off the utility value of additional people with the costs of a larger population. In this literature, an important parameter is the social weight placed on population size; a standard result is that a planner with a larger weight on population chooses larger population levels and growth rates. We demonstrate that this result is conditionally overturned when an exhaustible resource constraint is introduced: if the discount rate is small enough, the optimal population today decreases with the welfare weight on population size...
January 2018: Journal of Population Economics
https://www.readbyqxmd.com/read/29332812/thrombodynamics-a-new-global-coagulation-test-measurement-of-heparin-efficiency
#6
Elena I Sinauridze, Tatiana A Vuimo, Ivan D Tarandovskiy, Ruzanna A Ovsepyan, Stepan S Surov, Natalia G Korotina, Ilya I Serebriyskiy, Maxim M Lutsenko, Alexander L Sokolov, Fazoil I Ataullakhanov
The actual coagulation status may be reliably measured using only highly sensitive global functional tests; however, they are not numerous and all of them have disadvantages. Thrombodynamics (TD), a novel global coagulation test, is sensitive to hypo- and hypercoagulable states. The main properties of this test were investigated, and its capabilities for hemostasis analysis were verified through pharmacodynamic monitoring of the most widely used anticoagulants, heparins. The anticoagulant effects in the plasma of donors (n = 20) and patients after hip replacement (n = 20) spiked with unfractionated heparin or enoxaparin were measured in vitro to eliminate the influence of pharmacokinetic factors...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332336/downregulation-of-guanine-nucleotide-binding-protein-beta-1-gnb1-is-associated-with-worsened-prognosis-of-clearcell-renal-cell-carcinoma-and-is-related-to-vegf-signaling-pathway
#7
C Chen, H Chi, L Min, Z Junhua
PURPOSE: Clear-cell renal cell carcinoma (ccRCC) is characterized by genetic abnormalities, while the role of Guanine Nucleotide-Binding Protein Beta 1 (GNB1) in ccRCC has not been studied. We thus aimed to evaluate the expression and prognostic value of GNB1 in ccRCC. METHODS: A two-stage study (exploration and validation) was conducted using in silico and immunohistochemical (IHC) scoring of ccRCC samples from our institute, to evaluate the association between GNB1 expression and clinicopathological parameters of ccRCC patients...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332275/impact-of-drought-stress-induced-by-polyethylene-glycol-on-growth-water-relations-and-cell-viability-of-norway-spruce-seedlings
#8
Ilya E Zlobin, Yury V Ivanov, Alexander V Kartashov, Vladimir V Kuznetsov
We investigated physiological responses of 7-week-old Norway spruce seedlings to water deficits of different intensities. Hydroponically grown seedlings were subjected to mild (-0.15 MPa), strong (-0.5 and -1.0 MPa) and extreme (-1.5 MPa) water deficit induced by polyethylene glycol 6000, and their growth parameters, water status and physiological activity were analyzed. Seedlings effectively restricted water loss under drought, and even under extreme water deficit, shoot relative water content did not fall below 85%...
January 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29331677/identification-of-potential-mr-derived-biomarkers-for-tumor-tissue-response-to-177lu-octreotate-therapy-in-an-animal-model-of-small-intestine-neuroendocrine-tumor
#9
Mikael Montelius, Johan Spetz, Oscar Jalnefjord, Evelin Berger, Ola Nilsson, Maria Ljungberg, Eva Forssell-Aronsson
Magnetic resonance (MR) methods enable noninvasive, regional tumor therapy response assessment, but associations between MR parameters, underlying biology, and therapeutic effects must be investigated. The aim of this study was to investigate response assessment efficacy and biological associations of MR parameters in a neuroendocrine tumor (NET) model subjected to radionuclide treatment. Twenty-one mice with NETs received 177Lu-octreotate at day 0. MR experiments (day -1, 1, 3, 8, and 13) included T2-weighted, dynamic contrast-enhanced (DCE) and diffusion-weighted imaging (DWI) and relaxation measurements (T1/T2*)...
January 10, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29331414/inhibition-of-fasn-and-er%C3%AE-signalling-during-hyperglycaemia-induced-matrix-specific-emt-promotes-breast-cancer-cell-invasion-via-a-caveolin-1-dependent-mechanism
#10
H A Zielinska, J M P Holly, A Bahl, C M Perks
Since disturbed metabolic conditions such as obesity and diabetes can be critical determinants of breast cancer progression and therapeutic failure, we aimed to determine the mechanism responsible for their pro-oncogenic effects. Using non-invasive, epithelial-like ERα-positive MCF-7 and T47D human breast cancer cells we found that hyperglycaemia induced epithelial to mesenchymal transition (EMT), a key programme responsible for the development of metastatic disease. This was demonstrated by loss of the epithelial marker E-cadherin together with increases in mesenchymal markers such as vimentin, fibronectin and the transcription factor SLUG, together with an enhancement of cell growth and invasion...
January 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29331368/in-vitro-and-in-vivo-safety-analysis-of-enterococcus-faecium-2c-isolated-from-human-breast-milk
#11
Soodabeh Khalkhali, Naheed Mojgani
INTRODUCTION: Safety analysis of probiotic bacteria is an obligatory characteristic to be evaluated prior to application in food or pharmacological products. This study was designed to evaluate in vitro and in vivo safety parameters of Enterococcus faecium 2C strain, a probiotic candidate isolated from human breast milk. MATERIAL AND METHODS: E.faecium 2C was studied for its hemolytic activity and phenotypic antibiotics resistance profile. In vivo safety of the mentioned Enterococcus strain was studied by determining acute oral toxicity in Wistar Male rats...
January 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29330548/shox-haploinsufficiency-presenting-with-isolated-short-long-bones-in-the-second-and-third-trimester
#12
Shwetha Ramachandrappa, Abhijit Kulkarni, Hina Gandhi, Cheryl Ellis, Renata Hutt, Lesley Roberts, Rosol Hamid, Aris Papageorghiou, Sahar Mansour
Haploinsufficiency of the transcription factor short stature homeobox (SHOX) manifests as a spectrum of clinical phenotypes, ranging from disproportionate short stature and Madelung deformity to isolated short stature. Here, we describe five infants with molecularly confirmed diagnoses of SHOX haploinsufficiency who presented in utero with short long bones during routine antenatal scanning from as early as 19 weeks gestation. Other foetal growth parameters were normal. The molecular basis of SHOX haploinsufficiency was distinct in each case...
January 12, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29330362/dynamic-modelling-of-the-mtor-signalling-network-reveals-complex-emergent-behaviours-conferred-by-deptor
#13
Thawfeek M Varusai, Lan K Nguyen
The mechanistic Target of Rapamycin (mTOR) signalling network is an evolutionarily conserved network that controls key cellular processes, including cell growth and metabolism. Consisting of the major kinase complexes mTOR Complex 1 and 2 (mTORC1/2), the mTOR network harbours complex interactions and feedback loops. The DEP domain-containing mTOR-interacting protein (DEPTOR) was recently identified as an endogenous inhibitor of both mTORC1 and 2 through direct interactions, and is in turn degraded by mTORC1/2, adding an extra layer of complexity to the mTOR network...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330056/growth-scaling-for-the-early-dynamics-of-hiv-aids-epidemics-in-brazil-and-the-influence-of-socio-demographic-factors
#14
L Dinh, G Chowell, R Rothenberg
The early dynamics of an infectious disease outbreak can be affected by various factors including the transmission mode of the disease and host-specific factors. While recent works have highlighted the presence of sub-exponential growth patterns during the early phase of epidemics, empirical studies examining the contribution of different factors to early epidemic growth dynamics are lacking. Here we aim to characterize and explain the early incidence growth patterns of local HIV/AIDS epidemics in Brazil as a function of socio-demographic factors...
January 9, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29326072/novel-1-4-naphthoquinone-derivatives-induce-apoptosis-via-ros-mediated-p38-mapk-akt-and-stat3-signaling-in-human-hepatoma-hep3b-cells
#15
Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Jin
1,4-Naphthoquinone and its derivatives have shown some efficacy as therapeutic compounds for cancer and inflammation, though their clinical application is limited by their side-effects. To reduce the toxicity of these compounds and optimize their effects, we synthesized two 1,4-naphthoquinone derivatives-2-butylsulfinyl- 1,4-naphthoquinone (BSNQ) and 2-octylsulfinyl-1,4-naphthoquinone (OSNQ)-and investigated their effects and underlying mechanisms in hepatocellular carcinoma cells. BSNQ and OSNQ decreased cell viability and significantly induced apoptosis, accompanied by the accumulation of reactive oxygen species (ROS)...
January 8, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29325796/lcz696-sacubitril-valsartan-an-angiotensin-receptor-neprilysin-inhibitor-attenuates-cardiac-hypertrophy-fibrosis-and-vasculopathy-in-a-rat-model-of-chronic-kidney-disease
#16
Yasunori Suematsu, Wanghui Jing, Ane Nunes, Moti L Kashyap, Mahyar Khazaeli, Nosratola D Vaziri, Hamid Moradi
BACKGROUND: Chronic kidney disease (CKD) is associated with cardiac hypertrophy, fibrosis and increased risk of cardiovascular mortality. LCZ696 (Sacubitril/valsartan) is a promising agent which has shown significant potential in treatment of heart failure. We hypothesized that LCZ696 is more effective than valsartan alone in treatment of cardiovascular abnormalities associated with experimental CKD. METHODS AND RESULTS: Male Sprague Dawley rats underwent 5/6 nephrectomy and were subsequently randomized to no treatment (CKD), 30 mg/kg valsartan (VAL), or 60 mg/kg LCZ696 (LCZ)...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29325128/relationship-between-twelve-adipocytokines-and-distinct-components-of-the-metabolic-syndrome
#17
Thomas Ebert, Claudia Gebhardt, Markus Scholz, Tobias Wohland, Dorit Schleinitz, Mathias Fasshauer, Matthias Blüher, Michael Stumvoll, Peter Kovacs, Anke Tönjes
Objective: Adipose tissue-derived signals potentially link obesity and adipose tissue dysfunction with metabolic and cardiovascular diseases. Although some adipocytokines have been closely related to metabolic and cardiovascular traits, it remains open which adipocytokine or adipocytokine cluster serve as meaningful marker of metabolic syndrome (MS) components. Therefore, this study investigates the associations of twelve adipocytokines with components of the MS to identify the most relevant cytokines potentially related to specific metabolic profiles...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29325082/growth-parameters-effect-measure-modification-and-the-association-between-vaccination-and-early-childhood-hospitalization-with-non-targeted-infections
#18
David P Burgner, Jessica E Miller, Tobias Strunk, Natasha Nassar
No abstract text is available yet for this article.
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29325020/dynamic-effects-of-initial-ph-of-substrate-on-biological-growth-and-metamorphosis-of-black-soldier-fly-diptera-stratiomyidae
#19
Junhua Ma, Yanyan Lei, Kashif Ur Rehman, Ziniu Yu, Jibin Zhang, Wu Li, Qing Li, Jeffery K Tomberlin, Longyu Zheng
Edible insects have become a recognized alternative and sustainable source of high-quality proteins and fats for livestock or human consumption. In the production process of black soldier fly (BSF), (Hermetia illucens L. [Diptera: Stratiomyidae]), initial substrate pH is a critical parameter to ensure the best value of insect biomass, life history traits, and quality bio-fertilizer. This study examined the impact of initial pH values on BSF larvae production, development time, and adult longevity. The BSF were reared on artificial diet with initial pH of 2...
January 8, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29323661/versatile-technique-for-assessing-thickness-of-2d-layered-materials-by-xps
#20
Dmitry Y Zemlyanov, Michael Jespersen, Dmitri Zakharov, Jianjun Hu, Rajib Paul, Anurag Kumar, Shanee Pacley, Nicholas Glavin, David Saenz, K C Smith, Timothy S Fisher, Andrey A Voevodin
X-ray photoelectron spectroscopy (XPS) has been utilized as a versatile method for thickness characterization of various two-dimensional (2D) films. Accurate thicknesses can be measured simultaneously while acquiring XPS data for chemical characterization for 2D film thickness up to approximately 10 nm (<10 nm). For validating the developed technique, thicknesses of few-layer graphene (FLG), MoS2 and amorphous BN layers, produced by MPCVD, PECVD, and PLD respectively, are accurately measured. The ratio between photoemission peaks recorded for the films (C 1s, Mo 3d, B1s) and the substrates (Cu 2p, Si 2p, Al 2p) is the primary input parameter for the thickness calculation, in addition to the atomic densities of the substrate and the film, and corresponding electron attenuation length...
January 11, 2018: Nanotechnology
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