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https://www.readbyqxmd.com/read/29912253/-prevalence-and-susceptibility-pattern-of-bacteria-isolated-from-infected-chronic-wounds-in-adult-patients
#1
Víctor Silva, Alicia Marcoleta, Viviana Silva, Dángelo Flores, Teresa Aparicio, Isabel Aburto, Cecilia Latrach, Naldy Febré
BACKGROUND: Chronic wounds are considered a public health problem that may be complicated by bacterial infections, mainly caused by resistant strains. AIM: To study the bacteria prevalence and antimicrobial susceptibility in samples from adult patients with chronic wounds. METHODS: Patients treated at National Institute of Wounds Foundation between May and July 2014, with chronic ulcers in lower extremities with clinical inflammatory signs were recluted...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29912162/regulation-and-function-of-tmem16f-in-renal-podocytes
#2
Laura K Schenk, Jiraporn Ousingsawat, Boris V Skryabin, Rainer Schreiber, Hermann Pavenstädt, Karl Kunzelmann
The Ca2+ -activated phospholipid scramblase and ion channel TMEM16F is expressed in podocytes of renal glomeruli. Podocytes are specialized cells that form interdigitating foot processes as an essential component of the glomerular filter. These cells, which participate in generation of the primary urine, are often affected during primary glomerular diseases, such as glomerulonephritis and secondary hypertensive or diabetic nephropathy, which always leads to proteinuria. Because the function of podocytes is known to be controlled by intracellular Ca2+ signaling, it is important to know about the role of Ca2+ -activated TMEM16F in these cells...
June 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29910628/autoamputation-of-diabetic-toe-with-dry-gangrene-a-myth-or-a-fact
#3
REVIEW
Abdullah Al Wahbi
Diabetes is associated with various complications and reduced quality of life. Of the many complications, some are life-threatening. Among these, foot complications remain an important concern. The major foot complications include foot ulceration, cellulitis, abscess, wet gangrene, dry gangrene, and necrotizing fasciitis, with different pathophysiological concepts behind each of them. Gangrene occurs due to reduced blood supply in the body tissues that leads to necrosis. This condition may arise because of an injury, infection, or other health conditions, majorly diabetes...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29909681/is-it-necessary-to-change-instruments-between-sampling-sites-when-taking-multiple-tissue-specimens-in-musculoskeletal-infections
#4
D Makki, S Abdalla, T A El Gamal, D Harvey, G Jackson, S Platt
Introduction Surgical debridement of orthopaedic infections allows biopsy for microbiology and facilitates successful treatment. It is recommended that biopsy instruments are changed when taking multiple samples. This study compared assessed cross-contamination between biopsy sites when using same instruments to take tissue samples from multiple sites. Materials and methods During the surgical debridement, we defined five sampling sites and marked them with diathermy. Two sampling techniques were performed on same patient to minimise any potential bias arising from the type of host and the severity of infection...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909087/critical-appraisal-of-the-quality-of-evidence-addressing-the-diagnosis-prognosis-and-management-of-peripheral-artery-disease-in-patients-with-diabetic-foot-ulceration
#5
Stephen R Ali, Baris A Ozdemir, Robert J Hinchliffe
AIMS: There is a paucity of robust evidence on prevention and management of diabetic foot ulcers (DFUs) to inform treatment. This study appraises the current quality of the evidence addressing diagnosis, prognosis, and management of peripheral artery disease (PAD) in patients with DFUs using a newly devised 21 point scoring (TOPS) disease specific research appraisal tool published by the International Working Group on the Diabetic Foot (IWGDF) and European Wound Management Association...
June 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29907536/methicillin-resistant-staphylococcus-aureus-nasal-carriage-and-infection-among-patients-with-diabetic-foot-ulcer
#6
Shin-Yi Lin, Nai-Yu Lin, Yu-Yao Huang, Chi-Chun Hsieh, Yhu-Chering Huang
PURPOSE: To evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in patients with diabetic foot ulcer (DFU) in Taiwan, and to assess the concordance between colonizing and clinical MRSA isolates from the patients. METHOD: A total of 354 nasal specimens were collected from 112 to 242 diabetic patients with and without foot ulcer, respectively. MRSA clinical isolates from DFU wound cultures were collected for comparison. RESULTS: Nasal carriage rate of S...
June 4, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29907172/-nursing-care-of-a-patient-admitted-to-a-hyperbaric-chamber-for-a-chronic-wound
#7
Stéphanie Chevallier, Simon Le Nabat, Arnaud Druelle, Hugues Lefort, Jean-Éric Blatteau
The hyperbaric chamber is a particularly relevant therapy for the healing of chronic wounds such as radiation-induced wounds, ulcers, diabetic foot or osteomyelitis. This article describes the pathway of a patient with a chronic wound from the perspective of a hyperbaric medicine nurse.
June 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#8
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29904416/experimental-study-of-epidermal-growth-factor-and-acidic-fibroblast-growth-factor-in-the-treatment-of-diabetic-foot-wounds
#9
Jiasheng Xu, Dinghong Min, Guanghua Guo, Xincheng Liao, Zhonghua Fu
The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human EGF group (n=50), an aFGF group (n=50), a combined EGF and aFGF group (n=50) and a normal saline control group (n=49). Patients in all groups received a daily dressing change and growth factor reagents were applied topically when dressing...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904239/kinetic-studies-of-complex-biomedical-process-by-magnetic-resonance-cuban-experiences
#10
Carlos Cabal Mirabal, Adolfo Fernández García, Manuel Lores Guevara, Evelio González, Leonardo Oramas Díaz
The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with molecular, preclinical and clinical studies of significant diseases and drugs development. MR "in vitro" and "in vivo" studies of sickle cell disease, the diabetic foot ulcer, the brain tumor response and the magnetic nano-particle pharmacokinetics, are presented as example...
2018: Applied Magnetic Resonance
https://www.readbyqxmd.com/read/29902542/topical-epidermal-growth-factor-spray-for-the-treatment-of-chronic-diabetic-foot-ulcers-a-phase-iii-multicenter-double-blind-randomized-placebo-controlled-trial
#11
Kwang Hwan Park, Seung Hwan Han, Joon Pio Hong, Seung-Kyu Han, Doo-Hyung Lee, Bom Soo Kim, Jae Hoon Ahn, Jin Woo Lee
AIMS: This study was conducted to evaluate the efficacy and safety of a novel spray-applied growth factor therapy containing recombinant human epidermal growth factor (rhEGF) for the treatment of chronic diabetic foot ulcers (DFU). METHODS: This study was a phase III double-blind, randomized, placebo-controlled trial. 167 adult patients at six medical centers were randomized to receive routine wound care plus either topical spray treatment with 0.005% rhEGF (n = 82) or an equivalent volume of saline spray (n = 85) twice a day until ulcer healing or for up to 12 weeks...
June 11, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29901584/the-association-between-mcp-1-vegf-polymorphisms-and-their-serum-levels-in-patients-with-diabetic-foot-ulcer
#12
Xiaolei Li
The purpose of the present study was to investigate distribution of monocyte chemoattractant protein-1 (MCP-1) -2518A/G and vascular endothelial growth factor (VEGF) -634G/C polymorphisms in type 2 diabetes melitus patients (T2DM) presenting diabetic foot ulcer (DFU). Additionally, we evaluated the effects of these 2 polymorphisms on serum levels of MCP-1 and VEGF in the study population.Patients diagnosed with T2DM without or with DFU were recruited in the study. The distribution of MCP-1 -2518A/G and VEGF -634G/C polymorphisms was investigated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898825/improvement-of-the-quality-of-evidence-of-peripheral-artery-disease-in-diabetic-foot-ulceration-small-step-for-a-doctor-giant-leap-for-mankind
#13
Cornelis G Vos, Jean-Paul P M de Vries
No abstract text is available yet for this article.
June 10, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29896981/astragaloside-iv-ameliorates-early-diabetic-nephropathy-by-inhibition-of-mek1-2-erk1-2-rsk2-signaling-in-streptozotocin-induced-diabetic-mice
#14
Gaofeng Song, Pengxun Han, Huili Sun, Mumin Shao, Xuewen Yu, Wenjing Wang, Dongtao Wang, Wuyong Yi, Na Ge, Shunmin Li, Tiegang Yi
Objective The aim of this study was to investigate the renoprotective effects and molecular mechanisms of astragaloside IV (AS-IV) in streptozotocin (STZ)-induced diabetic mice. Methods Male C57BL/6 mice were injected intraperitoneally with STZ at 200 mg/kg body weight. AS-IV was administered for 8 consecutive weeks, beginning 1 week after STZ injection. Body weight, 24-hour urinary albumin excretion, and fasting blood glucose were measured. Kidney tissues were examined by histopathological analyses. Total levels and phosphorylation of mitogen-activated protein kinase 1/2 (MEK1/2), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and ribosomal S6 kinase 2 (RSK2) were determined by Western blotting analysis...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29895254/investigating-information-needs-of-saudi-diabetic-patients
#15
Irfan Anjum Manarvi, Nader Mahr Matta
BACKGROUND: Studies have shown that newly diagnosed diabetic patients need a lot of information about medical examinations, checkups, tests and precautions for its control besides its disastrous effects on heart, kidneys, eyes, foot and nerves etc. Patients in Saudi Arabia are generally not aware of most of the information they may need which is one the major reasons of its increasing number of patients. Past studies conducted are based on clinical data of hospitals and health care centers only discussed its effects...
June 11, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29893139/differences-predictors-and-moderators-of-therapeutic-adherence-in-patients-recently-diagnosed-with-type-2-diabetes
#16
M Graça Pereira, Susana Pedras, Gabriela Ferreira, José C Machado
This study analyzed the differences over time in newly diagnosed type 2 diabetes patients on reported adherence. A longitudinal design with two assessment moments was used with 268 patients who were assessed on adherence to self-care behaviors and medication, beliefs about medicines, psychological distress, trust in the physician, and satisfaction with care. HbA1c and general beliefs about medicines decreased from T1 to T2 while adherence to foot care, the needs of medicines, and psychological distress increased...
June 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29893030/relationships-of-health-literacy-to-self-care-behaviors-in-people-with-diabetes-aged-60-and-above-empowerment-as-a-mediator
#17
Kyung Suk Shin, Eun-Hyun Lee
AIM: To examine the relationships of health literacy to diabetes self-care behaviors (diet, physical exercise, foot care and blood glucose monitoring) through empowerment controlling for diabetes education. BACKGROUND: Potential mechanisms of how health literacy links to health outcomes have not clearly elucidated. DESIGN: A cross-sectional study design was used. METHODS: Participants were recruited from three community health centers in South Korea from September 2016 - April 2017 using a convenience sampling method...
June 11, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29892493/recurrence-of-critical-limb-ischemia-after-endovascular-intervention-in-patients-with-diabetic-foot-ulcers
#18
Marco Meloni, Valentina Izzo, Laura Giurato, Costantino Del Giudice, Valerio Da Ros, Valerio Cervelli, Roberto Gandini, Luigi Uccioli
Objective: To establish the rate of clinical recurrence of critical limb ischemia (CLI) in diabetic patients with ischemic foot ulcers (DFUs) treated by percutaneous transluminal angioplasty (PTA). Approach: The study group was composed of 304 patients with ischemic DFUs treated by PTA. We evaluated the rate of clinical recurrence of CLI requiring a second PTA (repeated PTA [rePTA]), the factors related to CLI relapse, and the outcomes of rePTA patients. The follow-up was 12.5 ± 6.6 months. Results: Seventy-four of 304 patients (24...
June 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29891655/potent-laminin-inspired-antioxidant-regenerative-dressing-accelerates-wound-healing-in-diabetes
#19
Yunxiao Zhu, Zdravka Cankova, Marta Iwanaszko, Sheridan Lichtor, Milan Mrksich, Guillermo A Ameer
The successful treatment of chronic dermal wounds, such as diabetic foot ulcers (DFU), depends on the development of safe, effective, and affordable regenerative tools that the surgeon can rely on to promote wound closure. Although promising, strategies that involve cell-based therapies and the local release of exogenous growth factors are costly, require very long development times, and result in modest improvements in patient outcome. We describe the development of an antioxidant shape-conforming regenerative wound dressing that uses the laminin-derived dodecapeptide A5G81 as a potent tethered cell adhesion-, proliferation-, and haptokinesis-inducing ligand to locally promote wound closure...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29890555/long-non-coding-rna-casc2-improves-diabetic-nephropathy-by-inhibiting-jnk-pathway
#20
Huihui Yang, Quan E Kan, Yong Su, Hua Man
It's known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption and smoking habits, but was correlated with course of disease...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
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