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Hournaz Hasanzadeh, Saman Ahmad Nasrollahi, Nader Halavati, Maryam Saberi, Alireza Firooz
INTRODUCTION: Male pattern hair loss is widespread around the world. Its prevalence indicates the importance of finding the best treatment modalities. This study evaluates the efficacy and safety of minoxidil 5% topical foam in male pattern hair loss treatment and patient satisfaction. METHODS: This study was a before-and-after trial on 17 male patients with male pattern hair loss. Subjects were instructed to apply one capful (1 ml) of minoxidil 5% topical foam on the scalp daily for 6 months...
September 2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Ulrike Baranyi, Andreas M Farkas, Karin Hock, Benedikt Mahr, Birgit Linhart, Martina Gattringer, Margit Focke-Tejkl, Arnd Petersen, Fritz Wrba, Thomas Rülicke, Rudolf Valenta, Thomas Wekerle
BACKGROUND: Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based therapy inducing permanent allergen-specific immunological tolerance for preventing IgE-mediated allergy. METHODS: Wild-type mice were treated with allergen-expressing bone marrow cells under a short course of tolerogenic immunosuppression (mTOR inhibition and costimulation blockade)...
May 2016: EBioMedicine
Mina Zarei, Tongyu C Wikramanayake, Leyre Falto-Aizpurua, Lawrence A Schachner, Joaquin J Jimenez
Despite the current treatment options for different types of alopecia, there is a need for more effective management options. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth. Here, we reviewed the current evidence on the LLLT effects with an evidence-based approach, focusing more on randomized controlled studies by critically evaluating them. In order to investigate whether in individuals presenting with hair loss (male pattern hair loss (MPHL), female pattern hair loss (FPHL), alopecia areata (AA), and chemotherapy-induced alopecia (CIA)) LLLT is effective for hair regrowth, several databases including PubMed, Google Scholar, Medline, Embase, and Cochrane Database were searched using the following keywords: Alopecia, Hair loss, Hair growth, Low level laser therapy, Low level light therapy, Low energy laser irradiation, and Photobiomodulation...
February 2016: Lasers in Medical Science
Abdulmaged M Traish, Roberto Cosimo Melcangi, Marco Bortolato, Luis M Garcia-Segura, Michael Zitzmann
Steroids are important physiological orchestrators of endocrine as well as peripheral and central nervous system functions. One of the key processes for regulation of these molecules lies in their enzymatic processing by a family of 5α-reductase (5α-Rs) isozymes. By catalyzing a key rate-limiting step in steroidogenesis, this family of enzymes exerts a crucial role not only in the physiological control but also in pathological events. Indeed, both 5α-R inhibition and supplementation of 5α-reduced metabolites are currently used or have been proposed as therapeutic strategies for a wide array of pathological conditions...
September 2015: Reviews in Endocrine & Metabolic Disorders
Dominique Van Neste
BACKGROUND: The words "hair growth" frequently encompass many aspects other than just growth. OBJECTIVES: Report on a validation method for precise non-invasive measurement of thickness together with linear hair growth rates of individual hair fibres. To verify the possible correlation between thickness and linear growth rate of scalp hair in male pattern hair loss as compared with healthy male controls. MATERIALS AND METHODS: To document the process of validation of hair growth measurement from in vivo image capturing and manual processing, followed by computer assisted image analysis...
September 2014: European Journal of Dermatology: EJD
Song Youn Park, Se Young Na, Jun Hwan Kim, Soyun Cho, Jong Hee Lee
Role of iron in hair loss is not clear yet. The purpose of this study was to evaluate the relationship between iron and hair loss. Retrospective chart review was conducted on patients with female pattern hair loss (FPHL) and male pattern hair loss (MPHL). All patients underwent screening including serum ferritin, iron, and total iron binding capacity (TIBC), CBC, ESR and thyroid function test. For normal healthy controls, age-sex matched subjects who had visited the hospital for a check-up with no serious disease were selected...
June 2013: Journal of Korean Medical Science
Pedram Fatehi, Jennifer Ryan, Yonghao Ni
The main objective of this work was to study the adsorption behavior of various components dissolved in the pre-hydrolysis of kraft process on activated carbon. In this work, model prehydrolysis liquor (PHL) solutions (MPHL)s were prepared via mixing various commercially available monosugars, xylan, lignin and furfural; and their adsorption performance on activated carbon (AC) was investigated. In singular (one component) MPHL/AC systems, furfural had the maximum and xylose had the minimum adsorption, and the adsorption of monosugars was basically similar on AC...
March 2013: Bioresource Technology
Anousha Yazdabadi, D Whiting, Nw Rufaut, R Sinclair
BACKGROUND: Hair follicle miniaturization is the hallmark of male pattern hair loss (MPHL), female pattern hair loss (FPHL), and alopecia areata (AA). AA has the potential for complete hair regrowth and reversal of miniaturization. MPHL and FPHL are either irreversible or show only partial regrowth and minimal reversal of miniaturization. HYPOTHESIS: The arrector pili muscle (APM) attachment to the hair follicle bulge, a recognized repository of stem cells may be necessary for reversal of hair follicle miniaturization...
July 2012: International Journal of Trichology
M Jesupillai, P Thillai Arasu, S Jasemine, P Bharathidhasan
OBJECTIVE: To evaluate anti convulsant effect of aerial parts of Phyllanthus longiflorus (PHL). MATERIALS AND METHOD: Methanol extract of aerial parts of PHL (MPHL) was prepared by continuous hot extraction method using Soxhlet apparatus. MPHL at the doses 100, 200 and 400 mg/kg were administered to male albino mice by oral route and the activity was assessed against maximal electro shock (MES) and pentylene tetrazole (PTZ) induced seizure. Abolition of hind limb extension and onset of clonic convulsion were taken as a measure of MES and PTZ induced convulsion respectively...
July 2012: European Review for Medical and Pharmacological Sciences
Michael S Irwig, Swapna Kolukula
INTRODUCTION: Finasteride has been associated with reversible adverse sexual side effects in multiple randomized, controlled trials for the treatment of male pattern hair loss (MPHL). The Medicines and Healthcare Products Regulatory Agency of the United Kingdom and the Swedish Medical Products Agency have both updated their patient information leaflets to include a statement that "persistence of erectile dysfunction after discontinuation of treatment with Propecia has been reported in post-marketing use...
June 2011: Journal of Sexual Medicine
Won-Serk Kim, Hye In Lee, Jin Woong Lee, Yun Young Lim, Seung Jae Lee, Beom Joon Kim, Myeung Nam Kim, Kye Yong Song, Won Serk Park
BACKGROUND: Various trials have been conducted on the management of male pattern hair loss (MPHL). A variety of laser and light sources have been used for the treatment of MPHL. OBJECTIVE: To understand the effects of a 1,550-nm fractional erbium-glass laser on the hair cycle in an alopecia mouse model and to study the clinical effects of the same laser used as treatment for MPHL. MATERIALS AND METHODS: Irradiation was applied to the shaved skin of C3H/HeN mice using various energy and density settings and varied irradiation intervals...
January 2011: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Deepani Rathnayake, Rodney Sinclair
Patterned hair loss in men and women, although medically benign, is a common, albeit unwelcome, event that may cause considerable anxiety and concern. Patterned hair loss is progressive and when untreated leads to baldness. The prevalence and severity of this physiologic process both increase with advancing age. Although androgens play a key role in the pathogenesis of male pattern hair loss (MPHL), the role of androgens in female pattern hair loss (FPHL) is less well established. Satisfactory treatment response to antiandrogen therapy supports the involvement of androgens in the pathogenesis of FPHL...
July 2010: Dermatologic Clinics
Thomas F Cash
OBJECTIVES: The study's objectives were (a) to characterize physicians' attitudes and practices in relation to treating male pattern hair loss (MPHL), (b) to examine differences vis-à-vis physician distinctions, and (c) to consider the findings in relation to published research on MPHL patients' treatment-seeking experiences. METHODS: The online survey across six countries (United States, France, Germany, Spain, Japan, and Korea) involved 466 physicians (263 dermatologists and 203 primary care physicians [PCPs]) who at least occasionally treat patients for MPHL...
February 2010: Current Medical Research and Opinion
Thomas F Cash
OBJECTIVES: The study's objectives were to characterize the concerns and self-treating efforts of men seeking medical treatment for male pattern hair loss (MPHL) and to describe their expectations and actual experiences of a physician consultation. METHODS: The online survey in six countries (United States, France, Germany, Spain, Japan, and Korea) involved 604 men (25-49 years old) self-identifying with MPHL. RESULTS: Approximately 75% of the study's treatment-seeking men were concerned, very concerned, or extremely concerned about their hair loss; 96% were at least somewhat concerned...
July 2009: Current Medical Research and Opinion
Chong Hyun Won, Oh Sang Kwon, Yeon Kyung Kim, Yong Jung Kang, Beom Joon Kim, Chong Won Choi, Hee Chul Eun, Kwang Hyun Cho
A relationship has been suggested between mast cells (MCs) and male pattern hair loss (MPHL), because of histological evidence of perifollicular fibrosis and increased mast cell numbers. Two paired punch biopsies were taken from balding vertexes and non-balding occipital promontory areas of ten patients with MPHL (Ludwig-Hamilton IIIv to IV) and from five normal subjects aged from 20 to 35 years. Masson trichrome and Victoria blue staining were performed to observe collagen frameworks and elastic fiber structures...
March 2008: Archives of Dermatological Research
Elise A Olsen, Maria Hordinsky, David Whiting, Dow Stough, Stuart Hobbs, Melissa L Ellis, Timothy Wilson, Roger S Rittmaster
BACKGROUND: Male pattern hair loss (MPHL) is a potentially reversible condition in which dihydrotestosterone is an important etiologic factor. OBJECTIVE: Our aim was to evaluate the efficacy of the type 1 and 2 5alpha-reductase inhibitor dutasteride in men with MPHL. METHODS: Four hundred sixteen men, 21 to 45 years old, were randomized to receive dutasteride 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks. RESULTS: Dutasteride increased target area hair count versus placebo in a dose-dependent fashion and dutasteride 2...
December 2006: Journal of the American Academy of Dermatology
Keith D Kaufman
Androgens have profound effects on scalp and body hair in humans. Scalp hair grows constitutively in the absence of androgens, while body hair growth is dependent on the action of androgens. Androgenetic alopecia, referred to as male pattern hair loss (MPHL) in men and female pattern hair loss (FPHL) in women, is due to the progressive miniaturization of scalp hair. Observations in both eunuchs, who have low levels of testicular androgens, and males with genetic 5alpha-reductase (5alphaR) deficiency, who have low levels of dihydrotestosterone (DHT), implicate DHT as a key androgen in the pathogenesis of MPHL in men...
December 30, 2002: Molecular and Cellular Endocrinology
J F Loring, J G Porter, J Seilhammer, M R Kaser, R Wesselschmidt
Embryonic stem (ES) cells have the ability to differentiate into a variety of cell lineages. We are examining ES cell differentiation in vitro by using cDNA microarrays to generate a molecular phenotype for each cell type. El4 ES cells induced by retinoic acid after forming embryoid bodies differentiate almost exclusively to neurons. We obtained expression patterns for about 8500 gene sequences by comparing mRNAs from undifferentiated ES cells and their differentiated derivatives in a competitive hybridization...
2001: Restorative Neurology and Neuroscience
(no author information available yet)
BACKGROUND: Finasteride 1 mg (Propecia) is indicated for the treatment of men with androgenetic alopecia (male pattern hair loss, MPHL). However, the long-term (> 2 years) efficacy and safety of finasteride in this population has not been previously reported. Objectives. To assess the efficacy and safety of finasteride in men with MPHL compared to treatment with placebo over five years. METHODS: In two 1-year, Phase III trials, 1,553 men with MPHL were randomized to receive finasteride 1 mg/day or placebo, and 1,215 men continued in up to four 1-year, placebo-controlled extension studies...
January 2002: European Journal of Dermatology: EJD
T Rhodes, C J Girman, R C Savin, K D Kaufman, S Guo, F R Lilly, R M Siervogel, W C Chumlea
BACKGROUND: Previous studies investigating the prevalence of male pattern hair loss (MPHL) typically used biased samples of men recruited from clinical populations which may limit generalizability of findings to broader populations. OBJECTIVE: To obtain an updated and improved estimate of the occurrence of MPHL in healthy men residing in the community. METHODS: Community-based sample of healthy men aged 18-49 years participated in a study investigating the effects of MPHL...
December 1998: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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