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Lumbar disc rupture

Xiao-Gang Liu, Hong-Wei Hou, Yi-Lin Liu
The present study aimed to investigate the expression and roles of interleukin (IL)-17 and tumor necrosis factor (TNF)-α in intervertebral disc degeneration (IDD) and to identify the association between the effects of IL-17 and TNF-α in IDD. This may increase understanding of the pathogenic mechanism underlying IDD, and aid the development of alternative therapies. The experimental group consisted of 40 samples of nucleus pulposus tissue obtained from the intervertebral discs (IVDs) of patients with IDD by surgical intervention, and was further divided into an annulus fibrosus disrupted group, comprising 18 patients in which the external annulus was ruptured, and an annulus fibrosus intact group comprising 22 patients...
June 2016: Experimental and Therapeutic Medicine
Hongqiang Jiang, Yao Deng, Tao Wang, Jianxiong Ma, Pengfei Li, Peng Tian, Chao Han, Xinlong Ma
BACKGROUND: Studies have indicated that interleukin 23 (IL-23) plays an important role in many inflammatory- and autoimmune-related diseases. However, there is little knowledge about IL-23 in lumbar disc herniation (LDH). Thus, in this study, we aimed to find out whether IL-23 is expressed in intervertebral discs (IVDs) and what roles it may play. METHODS: Human IVD tissues were collected from 29 LDH patients and 8 vertebral fracture patients (normal control, NC group)...
January 16, 2016: Journal of Orthopaedic Surgery and Research
Julio Urrutia, Tomas Zamora, Carlos Prada
PURPOSE: Several studies using magnetic resonance imaging (MRI) to evaluate the lumbar spine in adults have shown a large prevalence of degenerative changes in asymptomatic subjects; however, studies in pediatric patients are scarce. Those studies have suggested a lower rate of degenerative findings in adolescents than in adults, but the actual prevalence of MRI findings in the pediatric population has not yet been determined. We aimed to determine the prevalence of degenerative changes in the lumbar spine of pediatric patients using abdominal and pelvic MRI as the screening tool...
February 2016: European Spine Journal
Mireille E Kelley, Logan E Miller, Jillian E Urban, Joel D Stitzel
The brain-skull interface plays an important role in the strain and pressure response of the brain due to impact. In this study, a finite element (FE) model was developed from a brain atlas, representing an adult brain, by converting each 1mm isotropic voxel into a single element of the same size using a custom code developed in MATLAB. This model includes the brain (combined cerebrum and cerebellum), cerebrospinal fluid (CSF), ventricles, and a rigid skull. A voxel-based approach to develop a FE model causes the outer surface of each part to be stair-stepped, which may affect the stress and strain measurements at interfaces between parts...
2015: Biomedical Sciences Instrumentation
Kelly R Wade, Peter A Robertson, Ashvin Thambyah, Neil D Broom
STUDY DESIGN: Microstructural investigation of compression-induced herniation of the flexed lumbar disc. OBJECTIVE: To provide a microstructural analysis of the mechanisms of annular wall failure in healthy discs subjected to flexion and a rate of compression comparable with the maximum rate at which the muscles of the spinal column can generate a force. SUMMARY OF BACKGROUND DATA: Clinical evidence indicates the involvement of the endplate in herniation...
June 15, 2015: Spine
Bo-Gun Suh, Jae-Hyung Uh, Sang-Hyuk Park, Gun Woo Lee
STUDY DESIGN: A retrospective review of annulus fibrosus repair (AR) using a novel technique with a conventional implant. PURPOSE: The purpose of this study was to present the feasibility and clinico-radiological outcomes of a novel AR technique using a conventional implant to minimize recurrence following a lumbar discectomy (LD). OVERVIEW OF LITERATURE: Conventional repair techniques to prevent recurrence following LD have several drawbacks...
February 2015: Asian Spine Journal
Maida Koso, Kemal Dizdarevic, Jasmina Sose-Selimotic
BACKGROUND: Memory declines measured by traditional tests in patients after subarachnoid hemorrhage (SAH) are well documented. Classic examinations of memory problems sometimes do not significantly correlate with memory functions in everyday life. The objective of the study was to assess the specific type of everyday memory loss in patients after microsurgical treatment of ruptured intracranial aneurysm causing SAH. METHODS: The prospective controlled, randomized study was conducted using the specific tests for everyday memory measure with high ecological validity...
April 2015: Journal of Clinical Medicine Research
Samantha A Rodrigues, Ashvin Thambyah, Neil D Broom
BACKGROUND CONTEXT: The annulus-endplate anchorage system performs a critical role in the disc, creating a strong structural link between the compliant annulus and the rigid vertebrae. Endplate failure is thought to be associated with disc herniation, a recent study indicating that this failure mode occurs more frequently than annular rupture. PURPOSE: The aim was to investigate the structural principles governing annulus-endplate anchorage and the basis of its strength and mechanisms of failure...
March 1, 2015: Spine Journal: Official Journal of the North American Spine Society
Patcharin Chanapa, Tohno Yoshiyuki, Pasuk Mahakkanukrauh
Vertebral osteophytes are a characteristic feature of intervertebral disc degeneration. In the lumbar spinal region, the two major structures in close proximity anterior to the spine are the inferior vena cava and the abdominal aorta, both of which have been reported to be affected by osteophytes. The purpose of this study was to determine the distribution, classification and lengths of osteophytes in the lumbar vertebrae. One hundred and eighty lumbar columns of 90 males and 90 females from Chiang Mai, Thailand, in the age range 15 to 96 years (mean age, 63 years) were collected...
September 2014: Anatomy & Cell Biology
Brendan M Patterson, Reid W Draeger, Erik C Olsson, Jeffrey T Spang, Feng-Chang Lin, Ganesh V Kamath
BACKGROUND: Access to care is limited for patients with Medicaid with many conditions, but data investigating this relationship in the orthopaedic literature are limited. The purpose of this study was to investigate the relationship between health insurance status and access to care for a diverse group of adult orthopaedic patients, specifically if access to orthopaedic care is influenced by population density or distance from academic teaching hospitals. METHODS: Two hundred and three orthopaedic practices within the state of North Carolina were randomly selected and were contacted on two different occasions separated by three weeks...
September 17, 2014: Journal of Bone and Joint Surgery. American Volume
Peng-fei Yu, Hong Jiang, Jin-tao Liu, Xiao-chun Li, Xiang Qian, Song Han, Zhi-jia Ma
OBJECTIVE: To explore the therapeutic effects of a traditional Chinese medicine (TCM) regimen on patients with ruptured lumbar disc herniation, including assessing its effects on prognosis and protrusion size. METHODS: From June 2008 to December 2011, 102 patients with ruptured lumbar disc herniation who chose conservative treatment with TCM as their first choice were followed up for 2 years to assess their final surgical rate, improvement according to Japanese Orthopaedic Association (JOA) scores, and to calculate the volume and rate of resorption of their protrusions by magnetic resonance imaging (MRI)...
August 2014: Orthopaedic Surgery
Yasuchika Aoki, Arata Nakajima, Seiji Ohtori, Hiroshi Takahashi, Fusako Watanabe, Masato Sonobe, Fumiaki Terajima, Masahiko Saito, Kazuhisa Takahashi, Tomoaki Toyone, Atsuya Watanabe, Takayuki Nakajima, Makoto Takazawa, Koichi Nakagawa
INTRODUCTION: Nerve growth factor (NGF) has an important role in the generation of discogenic pain. We hypothesized that annular rupture is a trigger for discogenic pain through the action of NGF. In this study, the protein levels of NGF in discs from patients with disc herniation were examined and compared with those from discs of patients with other lumbar degenerative disc diseases. METHODS: Patients (n = 55) with lumbar degenerative disc disease treated by surgery were included...
2014: Arthritis Research & Therapy
Ting-Ying Lee, Chien-Sung Tsai, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Chanag Lin, Po-Shun Hsu
Ruptured abdominal aortic aneurysm is life-threatening without immediate management. The initial clinical presentation is non-specific and impending rupture is easily missed, especially without a CT scan. We present a case of a 56-year-old man with low-back pain and left lower-extremity numbness, which was diagnosed as a herniated intervertebral disc (HIVD) with left acute sciatica syndrome. He also complained of persistent fever and abdominal discomfort. Routine blood work-up revealed leukocytosis and decreasing haemoglobin levels...
June 23, 2014: Cardiovascular Journal of Africa
Amit Bhardwaj, Kavitha Nagandla
Low back pain is a common musculoskeletal symptom in pregnancy that can present as lumbar pain or pelvic girdle pain, with significant physical and psychosocial implications. Pelvic girdle pain is more prevalent and results in greater disability than lumbar pain. It is possible to distinguish between these two conditions from a detailed history based on the site of the pain, its intensity, disability and pain provocation tests. Management of low back pain in pregnancy is conservative, with physical exercise for lumbar pain and minimising activities that exacerbate pain, analgesics and bed rest for pelvic girdle pain, as well as avoiding abduction beyond the pain-free zone in labour...
August 2014: Postgraduate Medical Journal
Qian-Shi Zhang, Guo-Hua Lü, Xiao-Bin Wang, Jing Li
OBJECTIVES: To identify the negative effect on treatment results of reserving damaged intervertebral discs when treating type B and type C spinal fracture-dislocations through a one-stage posterior approach. METHODS: This is a retrospective review of 53 consecutive patients who were treated in our spine surgery center from January 2005 to May 2012 due to severe thoracolumbar spinal fracture-dislocation. The patients in Group A (24 patients) underwent long-segment instrumentation laminectomy with pedicle screw-rod fixators for neural decompression...
2014: PloS One
Hyun-Woo Lee, Young-Min Kwon
Intradural lumbar disc herniation is a rare disease. According to the reports of intradural lumbar disc herniations, most cases have developed as a chronic degenerative disc diseases. Traumatic intradural lumbar disc herniations are even rarer. A 52-year-old man visited our emergency center with numbness in his left calf and ankle after falling accident. Initial impression by radiologic findings was a spinal subdural hematoma at the L1 level. A follow up image two weeks later, however, did not demonstrate any interval change...
September 2013: Korean Journal of Spine
Fabrice A Kuelling, Kevin T Foley, Jane J Liu, Ellen Liebenberg, Anthony H Sin, Akihiro Matsukawa, Jeffrey C Lotz
BACKGROUND CONTEXT: Plasma-mediated radiofrequency-based ablation (coblation) is an electrosurgical technique currently used for tissue removal in a wide range of surgical applications, including lumbar microdiscectomy. In vitro and in vivo studies have shown the technique to alter the expression of inflammatory cytokines in the disc, increasing the levels of interleukin-8 (IL-8), which may promote maturation and remodeling of the disc matrix. PURPOSE: To better understand the effect of coblation treatment, this study characterizes the temporal and spatial pattern of healing after stab injury to the rabbit intervertebral disc, with and without plasma-mediated radiofrequency treatment...
October 1, 2014: Spine Journal: Official Journal of the North American Spine Society
Peng-Fei Yu, Fang-Da Jiang, Jin-Tao Liu, Hong Jiang
The authors set up a prospective study of the effect of conservative treatment on a ruptured lumbar disc herniation in 89 patients, between June 2008 and June 2010. Seventy-two patients (81%) improved, while the other 17 (19%) needed surgery. The JOA score (best possible result: 29) was found to be significantly improved in the 72 patients of the conservative group, at 1 month, 3 months, 6 months, 1 year and 2 years (t-test: p < 0.001). At final follow-up, after 2 years, 84.7% of the patients in the conservative group had a good or excellent result...
December 2013: Acta Orthopaedica Belgica
No abstract text is available yet for this article.
June 1956: Documenta Rheumatologica. [English Ed.]
Kelly R Wade, Peter A Robertson, Ashvin Thambyah, Neil D Broom
STUDY DESIGN: Microstructural investigation of compression-induced disruption of the flexed lumbar disc. OBJECTIVE: To provide a microstructural analysis of the mechanisms of annular wall failure in healthy discs subjected to flexion and an elevated rate of compression. SUMMARY OF BACKGROUND DATA: At the level of the motion segment failure of the disc in compression has been extensively studied. However, at the microstructural level the exact mechanisms of disc failure are still poorly understood, especially in relation to loading posture and rate...
June 1, 2014: Spine
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