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https://www.readbyqxmd.com/read/29921001/comparison-of-tissue-loss-by-different-punches-a-new-a-design
#1
Muhammad Ahmad
OBJECTIVES: To compare the amount of tissue loss using different FUE punches. MATERIALS AND METHODS: The study was conducted in 5 patients undergoing hair restoration surgery by FUE. Four different kinds of punches were used, that is, sharp, blunt, serrated, and new "A-design." All the punches had a total cutting edge of 0.8 mm. In each patient, 4 punches were used to make insertion at right angle with the skin. Immediately after the punch use, the diameter of the hole was measured...
June 19, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29902544/systematic-review-of-the-therapeutic-roles-of-adipose-tissue-in-dermatology
#2
REVIEW
Frances M Walocko, Ariel E Eber, Robert S Kirsner, Evangelos Badiavas, Keyvan Nouri
BACKGROUND: Adipose tissue has classically functioned as a filler in restoring facial volume. Adipose tissue is also rich in stem cells, which may have a role in regenerative medicine. OBJECTIVE: To summarize the literature on the clinical uses of adipose tissue in scarring, wound healing, and hair growth and determine if evidence exists for clinical practice changes in dermatology. METHODS: We utilized the Preferred Reporting Items for Systemic Reviews and Meta-Analysis (PRISMA) to conduct the review...
June 11, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29901127/microrna%C3%A2-183-is-involved-in-the-differentiation-and-regeneration-of-notch-signaling%C3%A2-prohibited-hair-cells-from-mouse-cochlea
#3
Wei Zhou, Jintao Du, Di Jiang, Xianren Wang, Kaitian Chen, Haocheng Tang, Xuemei Zhang, Hui Cao, Ling Zong, Chang Dong, Hongyan Jiang
Auditory hair cell regeneration following injury is critical to hearing restoration. The Notch signaling pathway participates in the regulation of inner ear development and cell differentiation. Recent evidence suggests that microRNA (miR)‑183 has a similar role in the inner ear. However, it is unclear how Notch signaling functions in hair cell regeneration in mammals and if there is cross‑talk between Notch signaling and miR‑183. The present study used a gentamicin‑induced cochlear injury mouse model...
June 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29868110/intracellular-regulome-variability-along-the-organ-of-corti-evidence-approaches-challenges-and-perspective
#4
REVIEW
Kevin T Booth, Hela Azaiez, Israt Jahan, Richard J H Smith, Bernd Fritzsch
The mammalian hearing organ is a regular array of two types of hair cells (HCs) surrounded by six types of supporting cells. Along the tonotopic axis, this conserved radial array of cell types shows longitudinal variations to enhance the tuning properties of basilar membrane. We present the current evidence supporting the hypothesis that quantitative local variations in gene expression profiles are responsible for local cell responses to global gene manipulations. With the advent of next generation sequencing and the unprecedented array of technologies offering high throughput analyses at the single cell level, transcriptomics will become a common tool to enhance our understanding of the inner ear...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29808708/alopecia-areata-and-the-gut-the-link-opens-up-for-novel-therapeutic-interventions
#5
Annika Borde, Annika Åstrand
This review aims to raise the potential of the modern society's impact on gut integrity often leading to increased intestinal permeability, as a cause or driver of Alopecia Areata (AA) in genetically susceptible people. With the increasing rate of T cell-driven autoimmunity, we hypothesize that there is a common root cause of these diseases that originates from chronic inflammation, and that the gut is the most commonly exposed area with our modern lifestyle. Areas covered: We will discuss the complexity in the induction of AA and its potential link to increased intestinal permeability...
May 29, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29797431/efficacy-of-non-surgical-treatments-for-androgenetic-alopecia-a-systematic-review-and-network-meta-analysis
#6
REVIEW
Aditya K Gupta, Rachel R Mays, Michelle S Dotzert, Sarah G Versteeg, Neil H Shear, Vincent Piguet
Androgenetic alopecia, or male/female pattern baldness, is the most common type of progressive hair loss disorder. The aim of this paper is to review recent advances in non-surgical treatments for androgenetic alopecia and identify the most effective treatments. A network meta-analysis (NMA) was conducted of the available literature of the six most common non-surgical treatment options for treating androgenetic alopecia in both men and women; dutasteride 0.5mg, finasteride 1mg, low level laser therapy (LLLT), minoxidil 2%, minoxidil 5% and platelet rich plasma (PRP)...
May 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29761529/pigmentation-and-vision-is-gpr143-in-control
#7
REVIEW
Brian S McKay
Albinism, typically characterized by decreased melanin synthesis, is associated with significant visual deficits owing to developmental changes during neurosensory retina development. All albinism is caused by genetic mutations in a group of diverse genes including enzymes, transporters, G-protein coupled receptor. Interestingly, these genes are not expressed in the neurosensory retina. Further, regardless of cause of albinism, all forms of albinism have the same retinal pathology, the extent of which is variable...
May 14, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29754876/bone-morphogenetic-protein-4-antagonizes-hair-cell-regeneration-in-the-avian-auditory-epithelium
#8
Rebecca M Lewis, Jesse J Keller, Liangcai Wan, Jennifer S Stone
Permanent hearing loss is often a result of damage to cochlear hair cells, which mammals are unable to regenerate. Non-mammalian vertebrates such as birds replace damaged hair cells and restore hearing function, but mechanisms controlling regeneration are not understood. The secreted protein bone morphogenetic protein 4 (BMP4) regulates inner ear morphogenesis and hair cell development. To investigate mechanisms controlling hair cell regeneration in birds, we examined expression and function of BMP4 in the auditory epithelia (basilar papillae) of chickens of either sex after hair cell destruction by ototoxic antibiotics...
May 2, 2018: Hearing Research
https://www.readbyqxmd.com/read/29744730/persistent-auditory-nerve-damage-following-kainic-acid-excitotoxicity-in-the-budgerigar-melopsittacus-undulatus
#9
Kenneth S Henry, Kristina S Abrams
Permanent loss of auditory nerve (AN) fibers occurs with increasing age and sound overexposure, sometimes without hair cell damage or associated audiometric threshold elevation. Rodent studies suggest effects of AN damage on central processing and behavior, but these species have limited capacity to discriminate low-frequency speech-like sounds. Here, we introduce a new animal model of AN damage in an avian communication specialist, the budgerigar (Melopsittacus undulatus). The budgerigar is a vocal learner and speech mimic with sensitive low-frequency hearing and human-like behavioral sensitivity to many complex signals including speech components...
May 9, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29733894/cochlear-hair-cell-regeneration-an-emerging-opportunity-to-cure-noise-induced-sensorineural-hearing-loss
#10
REVIEW
Ibrahima Youm, Wei Li
In mammals, cochlear hair cells have a pivotal role in transducing mechanical energy into electrical signals. Cochlear hair cells are sensitive to acoustic trauma, drug insults, aging, and environmental or genetic influences that can cause permanent hearing loss. Currently, much research is focusing on noise-induced sensorineural hearing loss (SNHL). Noise-induced SNHL is primarily caused by damage to hair cells of the cochlear sensory epithelium. Here, we summarize progress in restoring the sensory epithelium after SNHL resulting from noise exposure...
May 4, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29732346/a-new-algorithm-for-skin-lesion-border-detection-in-dermoscopy-images
#11
E Meskini, M S Helfroush, K Kazemi, M Sepaskhah
Background: With advances in medical imaging systems, digital dermoscopy has become one of the major imaging modalities in the analysis of skin lesions. Thus, automated segmentation or border detection has a great impact on the subsequent steps of skin cancer computer-aided diagnosis using demoscopy images. Since dermoscopy images suffer from artifacts such as shading and hair, there is a need for automated and robust artifact attenuation removal and lesion border detection. Methods: method for segmentation of dermoscopy images is proposed based on active contour...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29718413/understanding-molecular-evolution-and-development-of-the-organ-of-corti-can-provide-clues-for-hearing-restoration
#12
Israt Jahan, Karen L Elliott, Bernd Fritzsch
The mammalian hearing organ is a stereotyped cellular assembly with orderly innervation: two types of spiral ganglion neurons (SGNs) innervate two types of differentially distributed hair cells (HCs). HCs and SGNs evolved from single neurosensory cells through gene multiplication and diversification. Independent regulation of HCs and neuronal differentiation through expression of basic Helix-loop-Helix transcription factors (bHLH TFs: Atoh1, Neurog1, Neurod1) led to the evolution of vestibular HC assembly and their unique type of innervation...
April 26, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29707914/analysis-of-the-changes-in-scalp-hair-angles-in-vivo-and-in-vitro-comparison-before-and-after-tumescence
#13
Muhammad Ahmad, Mohammad Humayun Mohmand
OBJECTIVES: To estimate the hair shaft exit angles and also to check the effect of tumescence on the hair angles. MATERIALS AND METHODS: Ten patients undergoing first session of strip hair restoration were included. The strip was marked at the level of external occipital protuberance and superior nuchal line. Three hairs were marked, one near upper end, one near lower end, and one in the middle. About 10 mL of 0.5% xylocaine with adrenaline was used with the needle in the subdermal level...
April 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29692561/effect-of-different-polishing-methods-on-surface-roughness-of-provisional-prosthetic-materials
#14
Ívian Verena Maia Tupinambá, Priscila Couy Corrêa Giampá, Isadora Almeida Rios Rocha, Emilena Maria Castor Xisto Lima
Purpose: To evaluate the surface roughness of bis-acrylic and acrylic resins submitted to different methods of polishing. Materials and Methods: Fifty samples of each provisional restorative material (Structur 2, Protemp 4, Duralay, and Dencrilay) were fabricated (10 mm × 2 mm) and divided into five groups ( n = 10): (1) positive control group - polyester strip; (2) negative control - unpolished; (3) abrasive tips (Exa-Technique-Edenta); (4) goat hair brush and diamond polishing paste; and (5) silicone tips (Enhance)...
April 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29687797/impact-of-substrate-stiffness-on-dermal-papilla-aggregates-in-microgels
#15
Justin J Y Tan, Jie Kai Tee, Keat Onn Chou, Shi Ya Au Yong, Jing Pan, Han Kiat Ho, Paul C L Ho, Lifeng Kang
Interaction between cells and the extracellular environment plays a vital role in cellular development. The mechanical property of a 3-dimensional (3D) culture can be modified to mimic in vivo conditions. Dermal papilla (DP) cells are shown to gradually lose their inductivity in hair cycle development in a 2-dimensional culture. They are shown to partially restore their inductivity when transferred into a 3D microenvironment. In this study, a microarray fabricated from three different concentrations of poly-ethylene-glycol-diacrylate 3500, namely 5%, 10% and 15% w/v, yielded increasing substrate stiffness...
May 29, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29680697/regeneration-of-cochlear-hair-cells-and-hearing-recovery-through-hes1-modulation-with-sirna-nanoparticles-in-adult-guinea-pigs
#16
Xiaoping Du, Qunfeng Cai, Matthew B West, Ibrahima Youm, Xiangping Huang, Wei Li, Weihua Cheng, Don Nakmali, Donald L Ewert, Richard D Kopke
Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. We previously demonstrated that small interfering RNAs (siRNAs) directed against the Notch pathway gene, hairy and enhancer of split 1 (Hes1), encapsulated within biocompatible poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) could regenerate HCs within ototoxin-ablated murine organotypic cultures. In the present study, we delivered this sustained-release formulation of Hes1 siRNA (siHes1) into the cochleae of noise-injured adult guinea pigs...
May 2, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29618856/a-learning-module-in-hair-restoration-surgery-a-simple-and-economic-method-to-learn-all-steps-of-strip-method-of-hair-follicles-harvesting-and-implantation
#17
Anil Kumar Garg, Seema Garg
Background: There is a global increase in demand for hair transplant as well as increasing demand for trained assistants and surgeons. It is a fact that permanent donor hair follicles are limited and any loss during learning is permanent and irreversible, so there is no place to learn and/or practice on a patient. Objective: To develop a learning module in hair restoration surgery to learn all steps of strip method of hair follicles harvesting and methods of implantation...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29593497/reprogramming-glia-into-neurons-in-the-peripheral-auditory-system-as-a-solution-for-sensorineural-hearing-loss-lessons-from-the-central-nervous-system
#18
REVIEW
Steven J Meas, Chun-Li Zhang, Alain Dabdoub
Disabling hearing loss affects over 5% of the world's population and impacts the lives of individuals from all age groups. Within the next three decades, the worldwide incidence of hearing impairment is expected to double. Since a leading cause of hearing loss is the degeneration of primary auditory neurons (PANs), the sensory neurons of the auditory system that receive input from mechanosensory hair cells in the cochlea, it may be possible to restore hearing by regenerating PANs. A direct reprogramming approach can be used to convert the resident spiral ganglion glial cells into induced neurons to restore hearing...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29563738/reconstruction-of-the-major-defects-of-the-tissue-scalp
#19
M I Muradov, K B Mukhamedkerim, А А Baiguzeva, K E Kazantaev, D Zh Koshkarbaev
The problem of treating tissue defects of the scalp to date remains one of the actual problems of modern medicine. Low elasticity, stiffness, and the presence of hair follicles and skin deficit dictate the need for new treatments, cosmetic relevant requirements of this zone. The use of expander dermotension in recent years has found its wide distribution in the treatment of defects and deformities of covering tissue anywhere on the body. On the example of a patient K.32 years old hospitalized with diagnosis-basal cell epithelioma of the scalp-the defect of soft tissues, we demonstrated the use of expander plastic in the treatment of defect covering tissues of the scalp...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29543618/donor-site-assessment-for-female-hairline-restoration-in-southeast-asians
#20
Sittichai Ingprasert, Damkerng Pathomvanich, Patra Pinyopawasutthi
BACKGROUND: Female hairline restoration has increasingly been in demand for the past decade. However, no reports address the correlation between characteristics of hair at the hairline and at the donor area. OBJECTIVE: To assess follicular characteristics at the hairline and at the donor area including hair density, diameter, and their correlation. MATERIALS AND METHODS: One hundred one randomly selected Southeast Asian female volunteers were assessed for hairline and donor area characteristics...
March 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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