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https://www.readbyqxmd.com/read/29440850/a-meta-analysis-on-evidence-of-platelet-rich-plasma-for-androgenetic-alopecia
#1
Salvatore Giordano, Marco Romeo, Pietro di Summa, Andre' Salval, Petteri Lankinen
Background: Platelet-rich plasma (PRP) treatment has gained popularity among different surgical specialities for improving various conditions. Androgenetic alopecia (AGA) is a common disorder, with possible psychosocial implications. Plastic surgeons have increased the practice of PRP injections for hair restoration. A meta-analysis on this topic was performed comparing local injection of PRP versus control to investigate the efficacy of local PRP injections in AGA. Methods: We performed a systematic literature search...
January 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29424820/the-antioxidant-effect-of-rosmarinic-acid-by-different-delivery-routes-in-the-animal-model-of-noise-induced-hearing-loss
#2
Anna R Fetoni, Sara Letizia Maria Eramo, Antonella Di Pino, Rolando Rolesi, Fabiola Paciello, Claudio Grassi, Diana Troiani, Gaetano Paludetti
HYPOTHESIS: Trans-tympanic Rosmarinic Acid (RA), as compared with the systemic administration, protects against noise-induced auditory hair cell and hearing losses in rats in vivo. BACKGROUND: ROS production, lipoperoxidative damage, and an imbalance of antioxidant defences play a significant role in noise-induced hearing loss. Several molecules with antioxidant properties have been tested to restore redox homeostasis; however, drug delivery system represents a challenge for their effectiveness...
March 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29417383/targeted-heat-activation-of-hsp-promoters-in-the-skin-of-mammalian-animals-and-humans
#3
Richard Voellmy, Olivier Zürcher, Manon Zürcher, Pierre A de Viragh, Alexis K Hall, Stephen M Roberts
The use of highly inducible HSP promoters for exerting spatial and/or temporal control over the expression of therapeutic transgenes has long been discussed. Localized and time-limited induction of the heat shock response may potentially also be of medical interest. However, such applications would require targeted delivery of heat doses capable of activating HSP promoters in tissues or organs of interest. Accessible areas, including the skin and tissues immediately underneath it, may be most readily targeted...
February 7, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29413639/biotin-and-acetazolamide-for-treatment-of-an-unusual-child-with-autism-plus-lack-of-nail-and-hair-growth
#4
Paul J Benke, Michael Duchowny, Dianalee McKnight
BACKGROUND: Patients with autism spectrum disorder and developmental delay or encephalopathy rarely demonstrate no or negligible hair and nail growth, suggesting a biotin-responsive clinical disorder. METHODS: A ten-year-old girl presented with features of autism spectrum disorder, isolated headaches, and episodes of headaches and limb shaking. Her medical history revealed that her hair and nails did not grow. Administration of biotin restored her nail and hair growth and improved intellectual ability and school performance...
February 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29403358/novel-peptide-vaccine-gv1001-rescues-hearing-in-kanamycin-furosemide-treated-mice
#5
Shin Hye Kim, Gaon Jung, Sangjae Kim, Ja-Won Koo
The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model. In the present study, we administered GV1001 at different time points after inducing hair cell damage, and examined if it rescues hair cell loss and restores hearing. A deaf mouse model was created by intraperitoneal injection of KM and furosemide. First, to test the early temporal change of hearing and extent of hair cell damage after KM and furosemide injection, hearing and outer hair cells (OHCs) morphology were evaluated on day 1, day 2 and day 3 after injection...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29385890/unique-sensory-and-motor-behavior-in-thy1-gfp-m-mice-before-and-after-spinal-cord-injury
#6
Timothy D Faw, Jessica K Lerch, Tyler T Thaxton, Rochelle J Deibert, Lesley C Fisher, D Michele Basso
Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory and motor behavior of a common transgenic mouse line (Thy1-GFP-M) before and after SCI. Thy1-GFP-M positive (TG+) mice and their transgene negative littermates (TG-) were acquired from two sources (in-house colony n=32, Jackson Laboratories n=4)...
January 31, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29363542/ruxolitinib-protects-skin-stem-cells-and-maintains-skin-homeostasis-in-murine-graft-versus-host-disease
#7
Shuichiro Takahashi, Daigo Hashimoto, Eiko Hayase, Reiki Ogasawara, Hiroyuki Ohigashi, Takahide Ara, Emi Yokoyama, Ko Ebata, Satomi Matsuoka, Geoffrey Hill, Junichi Sugita, Masahiro Onozawa, Takanori Teshima
Graft-versus-host disease (GVHD) is the major complication after allogeneic stem cell transplantation (SCT). Emerging evidence indicates that GVHD leads to injury of intestinal stem cells. However, it remains to be investigated whether skin stem cells could be targeted in skin GVHD. Lgr5+ hair follicle stem cells (HFSCs) contribute to folliculogenesis and have a multipotent capacity to regenerate all epithelial cells in repair. We studied the fate of Lgr5+ HFSCs after SCT and explored the novel treatment to protect Lgr5+ HFSCs against GVHD using murine models of SCT...
January 23, 2018: Blood
https://www.readbyqxmd.com/read/29349046/reduction-of-closed-frontal-sinus-fractures-through-suprabrow-approach
#8
Hyung Min Hahn, Yoo Jung Lee, Myong Chul Park, Il Jae Lee, Sue Min Kim, Dong Ha Park
Background: The traditional approach for reduction of frontal sinus fractures is coronal incision. Inherent complications of the coronal approach include long scar, hair loss, and long operation time. We describe a simple approach for the reduction of frontal sinus anterior wall fractures using a suprabrow incision that is commonly used for brow lift. Methods: From March 2007 to October 2016, the authors identified patients with anterior wall frontal sinus fractures treated by open reduction through a suprabrow incision...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29340854/therapeutic-efficacy-and-safety-of-a-1927-nm-fractionated-thulium-laser-on-pattern-hair-loss-an-evaluator-blinded-split-scalp-study
#9
Sung Bin Cho, Boncheol Leo Goo, Zhenlong Zheng, Kwang Ho Yoo, Jin-Soo Kang, Heesu Kim
Laser- or light-assisted therapies have been used to improve the perifollicular environment by upregulating the expression of growth factors and signaling molecules for hair restoration. The aim of our study was to preclinically and clinically evaluate the therapeutic efficacy and safety of a 1927-nm fractionated thulium laser on pattern hair loss (PHL). An in vivo hairless mouse study and an in vivo human skin environmental scanning electron microscopy (ESEM) study were performed with different power and energy settings...
January 16, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29313075/children-s-hair-mercury-concentrations-and-seafood-consumption-in-five-regions-of-japan
#10
Emiko Kusanagi, Hitoshi Takamura, Shing-Jen Chen, Mayumi Adachi, Nobuko Hoshi
Exposure to methylmercury (MeHg) during the foetal and postnatal periods is known to have adverse effects on children's development. However, little attention has been paid to MeHg exposure during early childhood in Japan. To examine the regional differences in MeHg exposure and seafood consumption and the association between MeHg exposure and seafood consumption and dental metal restorations, we measured the total mercury (T-Hg) concentration in hair as an MeHg exposure index, and using questionnaires, we measured the frequency and amount of seafood consumption and the presence of dental metal restorations in 118 children aged 3-6 years in five regions of Japan...
January 8, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29312816/first-record-of-phormia-regina-meigen-1826-diptera-calliphoridae-from-mummies-at-the-sant-antonio-abate-cathedral-of-castelsardo-sardinia-italy
#11
Giorgia Giordani, Fabiola Tuccia, Ignazio Floris, Stefano Vanin
The studies of insects from archaeological contexts can provide an important supplement of information to reconstruct past events, climate and environments. Furthermore, the list of the species present in an area in the past allows the reconstruction of the entomofauna on that area at that time, that can be different from the nowadays condition, providing information about biodiversity changes. In this work, the results of a funerary archaeoentomological study on samples collected from mummified corpses discovered during the restoration of the crypt of the Sant'Antonio Abate Cathedral of Castelsardo (Sardinia, Italy) are reported...
2018: PeerJ
https://www.readbyqxmd.com/read/29310861/never-too-old-to-regenerate-wound-induced-hair-follicle-neogenesis-after-secondary-intention-healing-in-a-geriatric-patient
#12
Tak-Wah Wong, Michael Hughes, Szu-Han Wang
Wound healing is a natural process to restore the structure and function of injured or diseased tissues. Repair of a skin wound usually leads to a scar while regeneration implies fully recovery of function and structure of the damaged tissue. Adult skin wound usually heals with scar while fetal skin heals scarless. Hair regeneration in elderly scalp wound has never been observed. We reported an 80-year-old patient with a large wound on the scalp after excision of a basal cell carcinoma healed by secondary intention wound healing...
January 4, 2018: Journal of Tissue Viability
https://www.readbyqxmd.com/read/29301392/clinical-safety-and-efficacy-of-autologous-bone-marrow-derived-mesenchymal-stem-cell-transplantation-in-sensorineural-hearing-loss-patients
#13
Ho Seok Lee, Woo Jin Kim, Ji Sun Gong, Kyoung Ho Park
Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing...
January 5, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29285533/scaffold-assisted-artificial-hair-implantation-in-a-rat-model
#14
Joshua K Au, Miguel Fernando Palma Diaz, Tara Aghaloo, Maie A St John
Importance: Current treatments for alopecia with autograft hair transplantation face limitations that may preclude complete hair restoration and leave patients with donor site scars. Scaffold assisted artificial hair implantation as demonstrated in a rat model may provide an adjunct for hair restoration without donor site morbidity. Objective: To design and create porous high-density polyethylene (PHDPE) and expanded polytetrafluoroethylene (ePTFE) hair-bearing scaffolds and evaluate their biocompatibility in a rat model...
December 28, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29273098/hair-follicle-immune-privilege-revisited-the-key-to-alopecia-areata-management
#15
REVIEW
Ralf Paus, Silvia Bulfone-Paus, Marta Bertolini
The collapse of the immune privilege (IP) of the anagen hair bulb is now accepted as a key element in AA pathogenesis, and hair bulb IP restoration lies at the core of AA therapy. Here, we briefly review the essentials of hair bulb IP and recent progress in understanding its complexity. We discuss open questions and why the systematic dissection of hair bulb IP and its pharmacological manipulation (including the clinical testing of FK506 and α-melanocyte-stimulating hormone analogs) promise to extend the range of future therapeutic options in AA and other IP collapse-related autoimmune diseases...
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29227036/bottom-up-nanoencapsulation-from-single-cells-to-tunable-and-scalable-cellular-spheroids-for-hair-follicle-regeneration
#16
Jin Wang, Yong Miao, Yong Huang, Bojie Lin, Xiaomin Liu, Shune Xiao, Lijuan Du, Zhiqi Hu, Malcolm Xing
Cell surface engineering technology advances cell therapeutics and tissue engineering by accurate micro/nanoscale control in cell-biomaterial ensembles and cell spheroids formation. By tailoring cell surface, microgels can encapsulate cells for versatile uses. However, microgels are coated in a thick layer to house multiple cells together but not a single cell based. Besides, excessive deposition on cell surface is detrimental to cellular functions. Herein, layer-by-layer (LbL) self-assembly to encapsulate single cell using nanogel is reported, owing to its security and tunable thickness at nanoscale, and further forms cell spheroids by physical cross-linking on nanogel-coated cells for delivery...
December 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29182629/effects-of-peroxisome-proliferator-activated-receptors-ppar-%C3%AE-and-%C3%AE-agonists-on-cochlear-protection-from-oxidative-stress
#17
Marijana Sekulic-Jablanovic, Vesna Petkovic, Matthew B Wright, Krystsina Kucharava, Nathan Huerzeler, Soledad Levano, Yves Brand, Katharina Leitmeyer, Andrea Glutz, Alexander Bausch, Daniel Bodmer
Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabetes and dyslipidemia. These agents target the peroxisome proliferator-activated receptors, PPARγ and PPARα, which are transcription factors that influence glucose and lipid metabolism, inflammation, and organ protection. In this study, we explored the effects of pioglitazone and other PPAR agonists to prevent gentamicin-induced oxidative stress and apoptosis in mouse organ of Corti (OC) explants...
2017: PloS One
https://www.readbyqxmd.com/read/29108548/new-generation-therapies-for-the-treatment-of-hair-loss-in-men
#18
REVIEW
Neil S Sadick
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction/grafting that can offer patients excellent clinical results. Adjuvant modalities, such as platelet-rich plasma injections, lasers, and stem cells, can further enhance durability, health, and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29108547/advances-in-hair-restoration
#19
REVIEW
Paul T Rose
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychological and emotional well-being. Hair restoration technologies have advanced with the use of robotics and manual and motorized follicular unit extraction to provide patients excellent clinical results. Adjuvant modalities such as platelet-rich plasma injections, lasers and stem cells can further enhance the survivability and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29107558/esrp1-mutations-cause-hearing-loss-due-to-defects-in-alternative-splicing-that-disrupt-cochlear-development
#20
Alex M Rohacek, Thomas W Bebee, Richard K Tilton, Caleb M Radens, Chris McDermott-Roe, Natoya Peart, Maninder Kaur, Michael Zaykaner, Benjamin Cieply, Kiran Musunuru, Yoseph Barash, John A Germiller, Ian D Krantz, Russ P Carstens, Douglas J Epstein
Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in auditory development remains unclear. We performed whole-exome sequencing in individuals with sensorineural hearing loss (SNHL) and identified pathogenic mutations in Epithelial Splicing-Regulatory Protein 1 (ESRP1). Patient-derived induced pluripotent stem cells showed alternative splicing defects that were restored upon repair of an ESRP1 mutant allele. To determine how ESRP1 mutations cause hearing loss, we evaluated Esrp1(-/-) mouse embryos and uncovered alterations in cochlear morphogenesis, auditory hair cell differentiation, and cell fate specification...
November 6, 2017: Developmental Cell
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