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https://www.readbyqxmd.com/read/29227036/bottom-up-nanoencapsulation-from-single-cells-to-tunable-and-scalable-cellular-spheroids-for-hair-follicle-regeneration
#1
Jin Wang, Yong Miao, Yong Huang, Bojie Lin, Xiaomin Liu, Shune Xiao, Lijuan Du, Zhiqi Hu, Malcolm Xing
Cell surface engineering technology advances cell therapeutics and tissue engineering by accurate micro/nanoscale control in cell-biomaterial ensembles and cell spheroids formation. By tailoring cell surface, microgels can encapsulate cells for versatile uses. However, microgels are coated in a thick layer to house multiple cells together but not a single cell based. Besides, excessive deposition on cell surface is detrimental to cellular functions. Herein, layer-by-layer (LbL) self-assembly to encapsulate single cell using nanogel is reported, owing to its security and tunable thickness at nanoscale, and further forms cell spheroids by physical cross-linking on nanogel-coated cells for delivery...
December 11, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29182629/effects-of-peroxisome-proliferator-activated-receptors-ppar-%C3%AE-and-%C3%AE-agonists-on-cochlear-protection-from-oxidative-stress
#2
Marijana Sekulic-Jablanovic, Vesna Petkovic, Matthew B Wright, Krystsina Kucharava, Nathan Huerzeler, Soledad Levano, Yves Brand, Katharina Leitmeyer, Andrea Glutz, Alexander Bausch, Daniel Bodmer
Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabetes and dyslipidemia. These agents target the peroxisome proliferator-activated receptors, PPARγ and PPARα, which are transcription factors that influence glucose and lipid metabolism, inflammation, and organ protection. In this study, we explored the effects of pioglitazone and other PPAR agonists to prevent gentamicin-induced oxidative stress and apoptosis in mouse organ of Corti (OC) explants...
2017: PloS One
https://www.readbyqxmd.com/read/29108548/new-generation-therapies-for-the-treatment-of-hair-loss-in-men
#3
REVIEW
Neil S Sadick
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction/grafting that can offer patients excellent clinical results. Adjuvant modalities, such as platelet-rich plasma injections, lasers, and stem cells, can further enhance durability, health, and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29108547/advances-in-hair-restoration
#4
REVIEW
Paul T Rose
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychological and emotional well-being. Hair restoration technologies have advanced with the use of robotics and manual and motorized follicular unit extraction to provide patients excellent clinical results. Adjuvant modalities such as platelet-rich plasma injections, lasers and stem cells can further enhance the survivability and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29107558/esrp1-mutations-cause-hearing-loss-due-to-defects-in-alternative-splicing-that-disrupt-cochlear-development
#5
Alex M Rohacek, Thomas W Bebee, Richard K Tilton, Caleb M Radens, Chris McDermott-Roe, Natoya Peart, Maninder Kaur, Michael Zaykaner, Benjamin Cieply, Kiran Musunuru, Yoseph Barash, John A Germiller, Ian D Krantz, Russ P Carstens, Douglas J Epstein
Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in auditory development remains unclear. We performed whole-exome sequencing in individuals with sensorineural hearing loss (SNHL) and identified pathogenic mutations in Epithelial Splicing-Regulatory Protein 1 (ESRP1). Patient-derived induced pluripotent stem cells showed alternative splicing defects that were restored upon repair of an ESRP1 mutant allele. To determine how ESRP1 mutations cause hearing loss, we evaluated Esrp1(-/-) mouse embryos and uncovered alterations in cochlear morphogenesis, auditory hair cell differentiation, and cell fate specification...
November 6, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29084289/neuronal-differentiation-of-hair-follicle-bulge-derived-stem-cells-co-cultured-with-mouse-cochlear-modiolus-explants
#6
Timo Schomann, Laura Mezzanotte, John C M J De Groot, Marcelo N Rivolta, Sanne H Hendriks, Johan H M Frijns, Margriet A Huisman
Stem-cell-based repair of auditory neurons may represent an attractive therapeutic option to restore sensorineural hearing loss. Hair-follicle-bulge-derived stem cells (HFBSCs) are promising candidates for this type of therapy, because they (1) have migratory properties, enabling migration after transplantation, (2) can differentiate into sensory neurons and glial cells, and (3) can easily be harvested in relatively high numbers. However, HFBSCs have never been used for this purpose. We hypothesized that HFBSCs can be used for cell-based repair of the auditory nerve and we have examined their migration and incorporation into cochlear modiolus explants and their subsequent differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/29079536/restoration-of-skin-pigmentation-after-deep-partial-or-full-thickness-burn-injury
#7
Niann-Tzyy Dai, Hsin-I Chang, Yi-Wen Wang, Keng-Yen Fu, Tai-Chun Huang, Nien-Chi Huang, Jhen-Kai Li, Pai-Shan Hsieh, Lien-Guo Dai, Chao-Kuei Hsu, Peter K Maitz
Significant skin pigmentation changes occur when patients suffer deep burn injuries. These pigmentation disorders may cause not only cosmetic and psychological issues, but more importantly it increases the risk of skin cancer or photoaging. Severe burns significantly effect on the process of repigmentation as the pigmentation is tightly regulated by cell proliferation and differentiation of melanocytes and melanocyte stem cells which are housing in the epidermis and hair follicles of the skin. In the present review, we discuss the possible mechanisms to replenish the melanocytes from the healthy epidermis and hair follicles surrounding burn wounds...
October 24, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29064980/hair-transplantation-controversies
#8
REVIEW
Marc R Avram, Robert Finney, Nicole Rogers
BACKGROUND: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss. OBJECTIVE: To review some current controversies in hair transplant surgery. MATERIALS AND METHODS: Review of the English PubMed literature and specialty literature in hair transplant surgery. RESULTS: Some of the controversies in hair transplant surgery include appropriate donor harvesting technique including elliptical donor harvesting versus follicular unit extraction whether manual versus robotic, the role of platelet-rich plasma and low-level light surgery in hair transplant surgery...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29060675/effect-of-laser-diode-light-irradiation-on-growth-capability-of-human-hair-follicle-dermal-papilla-cells
#9
S Jampa-Ngern, K Viravaidya-Pasuwat, S Suvanasuthi, A Khantachawana
Low level laser therapy is widely used to relieve pain and inflammation, and to restore cellular functions. The photons of light are absorbed by mitochondria in cells, leading to an increase in the production of adenosine triphosphate (ATP), nitric oxide release, blood flow, and reactive oxygen species (ROS). This study proposed the use of a laser diode array at 808 nm to stimulate the proliferation and to activate the functions of dermal papilla cells, which were an important part of the hair growth cycle...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057586/mercury-levels-in-hair-samples-of-dentists-a-comparative-study-in-sri-lanka
#10
Lumbini A Wijesekara, Rinzee Usoof, Sachindra S T Gamage, Ruwan Jayasinghe, Nandasena Gamage, Dileep De Silva, Sagarika Ekanayake
AIM: Elemental mercury is widely used in dentistry as dental amalgam. Hair samples constitute preferred biomarkers to determine the index of mercury exposure. In the absence of any published studies, the aim of the present study was to ascertain the level of mercury in a selected sample of dentists and controls in Sri Lanka. METHODS: Hair samples (.7 g) from dentists working in and around the Colombo district in Sri Lanka (n = 50) and controls (n = 50) were digested with sulfuric acid-potassium permanganate solution, and reduced to metallic mercury with stannous chloride...
October 22, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29040358/tissue-expansion-using-hyaluronic-acid-filler-for-single-stage-ear-reconstruction-a-novel-concept-for-difficult-areas
#11
Amir Inbal, Benjamin T Lemelman, Eran Millet, Andrew Greensmith
Background: Auricular reconstruction is one of the most challenging procedures in plastic surgery. An adequate skin envelope is essential for cartilage framework coverage, yet few good options exist without additional surgery. We propose a novel method for minimally invasive tissue expansion, using hyaluronic acid (HA) filler to allow for single-stage ear reconstruction. Objectives: To introduce the novel concept of HA filler for tissue expansion in ear reconstruction, and as an alternative to traditional expansion techniques...
October 16, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29019741/activation-of-mtorc1-signaling-is-required-for-timely-hair-follicle-regeneration-from-radiation-injury
#12
Wei-Hung Wang, Ting-Han Chien, Sabrina Mai-Yi Fan, Wen-Yen Huang, Shih-Fan Lai, June-Tai Wu, Sung-Jan Lin
Transit amplifying cells (TACs) are highly proliferative in nature and tend to be sensitive to ionizing radiation. Due to the abundance of TACs that support the elongation of hair shafts, growing hair follicles are highly sensitive to radiation injury. How hair follicles repair themselves after radiation injury is unclear. In this study, we observed that in 4 Gy irradiated mice, hair follicle dystrophy was induced with apoptosis-driven loss of hair matrix cells, which are the TACs that fuel hair growth. The dystrophy was repaired within 96 h without significant hair loss, indicating that a regenerative attempt successfully restored the TAC population to resume anagen growth...
October 11, 2017: Radiation Research
https://www.readbyqxmd.com/read/28992413/phenotypic-optimization-of-urea-thiophene-carboxamides-to-yield-potent-well-tolerated-and-orally-active-protective-agents-against-aminoglycoside-induced-hearing-loss
#13
Sarwat Chowdhury, Kelly N Owens, R Jason Herr, Qin Jiang, Xinchao Chen, Graham Johnson, Vincent E Groppi, David W Raible, Edwin W Rubel, Julian A Simon
Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells, a robust model for mammalian auditory and vestibular hair cells, we identified a urea-thiophene carboxamide, 1 (ORC-001), as protective against aminoglycoside antibiotic (AGA)-induced hair cell death. The 50% protection (HC50) concentration conferred by 1 is 3.2 μM with protection against 200 μM neomycin approaching 100%. Compound 1 was sufficiently safe and drug-like to validate otoprotection in an in vivo rat hearing loss model...
October 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28990286/a-new-practical-classification-for-spatial-distribution-and-morphology-of-human-hair-ahmad-s-lgma-classification
#14
Muhammad Ahmad
BACKGROUND: The human hair is a complex structure with a diversity within itself. There is a wide variation in distribution and spatial arrangement of hairs. METHODS: The current classification was developed on the basis of high-resolution photographs of adult human scalp. RESULTS: On the observation, the new classification consisted of 4 categories. CONCLUSIONS: It will help the hair restoration surgeons and dermatologists to identify the various pattern and also to help in deciding the appropriate size of the punch in FUE...
October 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28979149/conventional-and-novel-stem-cell-based-therapies-for-androgenic-alopecia
#15
REVIEW
Dodanim Talavera-Adame, Daniella Newman, Nathan Newman
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#16
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28931463/severe-streptomycin-ototoxicity-in-the-mouse-utricle-leads-to-a-flat-epithelium-but-the-peripheral-neural-degeneration-is-delayed
#17
Guo-Peng Wang, Ishani Basu, Lisa A Beyer, Hiu Tung Wong, Donald L Swiderski, Shu-Sheng Gong, Yehoash Raphael
The damaged vestibular sensory epithelium of mammals has a limited capacity for spontaneous hair cell regeneration, which largely depends on the transdifferentiation of surviving supporting cells. Little is known about the response of vestibular supporting cells to a severe insult. In the present study, we evaluated the impact of a severe ototoxic insult on the histology of utricular supporting cells and the changes in innervation that ensued. We infused a high dose of streptomycin into the mouse posterior semicircular canal to induce a severe lesion in the utricle...
November 2017: Hearing Research
https://www.readbyqxmd.com/read/28918299/the-prosthetic-rehabilitation-of-a-patient-with-a-lateral-postsurgical-defect-using-a-2-piece-magnet-retained-facial-prosthesis-a-clinical-report
#18
Kariem M Elhelow, Yasser E Al-Thobaiti, Abdurabu A Gomawi
Nonsurgical prosthetic interventions are often proposed after repeated grafts have failed to restore irradiated facial defects. This report describes a facial prosthetic reconstruction following ablative surgery for a sizable facial tumor by using a novel custom-made magnet-bearing substructure, which connected with an exposed part of the mandibular reconstruction plate. The defect involved the entire left lower part of the face and angle of the mentum. This reconstructive technique, together with an added surface texture with hair-like silicone strands, effectively addressed the cosmetic needs of the patient...
September 14, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#19
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28885585/hair-regenerative-mechanisms-of-red-ginseng-oil-and-its-major-components-in-the-testosterone-induced-delay-of-anagen-entry-in-c57bl-6-mice
#20
Van-Long Truong, Min Ji Bak, Changook Lee, Mira Jun, Woo-Sik Jeong
Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil (RGO) and its major components on hair re-growth using testosterone (TES)-induced delay of anagen entry in C57BL/6 mice and their mechanisms of action. Seven-week-old C57BL/6 mice were daily treated with TES for 1 h prior to topical application of 10% RGO, 1% linoleic acid (LA), 1% β-sitosterol (SITOS), or 1% bicyclo(10.1.0)tridec-1-ene (BICYCLO) once a day for 28 days...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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