keyword
MENU ▼
Read by QxMD icon Read
search

Hemostasis

keyword
https://www.readbyqxmd.com/read/29470988/shear-dependent-fibrillogenesis-of-fibronectin-impact-of-platelet-integrins-and-actin-cytoskeleton
#1
Huong Nguyen, Khon Huynh, Volker R Stoldt
Soluble plasma fibronectin (Fn) with its inactive compact structure requires unfolding to assemble into active fibrils, which play a role in hemostasis and thrombosis. Fn fibril assembly involves Fn binding to cell receptors, biomechanical coupling of Fn to the cytoskeleton by integrins, exposure of self-assembly sites via contractile cell forces, and elongation of fibrils by Fn polymerization. In this report, we investigated the effect of platelet integrins and actin cytoskeleton on conformational changes of Fn induced by shear...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29469043/viscoelastic-testing-in-liver-disease
#2
Jessica P E Davis, Patrick G Northup, Stephen H Caldwell, Nicolas M Intagliata
Long thought to be hypocoagulable, new evidence suggests cirrhosis patients have "rebalanced" coagulation in the setting of decreased synthesis of both pro- and anti-coagulant factors. Traditional testing like PT/INR reflects only the decreased synthesis of pro-coagulant factors and thus does not correspond to bleeding or clotting risk in this population. In this review, we discuss the use of viscoelastic testing (VET), an assay of global hemostasis in cirrhosis patients. We describe the technique and interpretation of commercially available VET and assess the application of VET in both transplant and non-transplant cirrhosis populations...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29467183/the-search-for-new-antithrombotic-mechanisms-and-therapies-that-may-spare-hemostasis
#3
Edward F Plow, Yunmei Wang, Daniel I Simon
Current antithrombotic drugs, including widely used antiplatelet agents and anticoagulants, are associated with significant bleeding risk, which increases morbidity and mortality. Nevertheless, there is emerging experimental evidence that suggests that the molecular and cellular mechanisms of hemostasis and thrombosis can be separated, thereby raising the possibility of new antithrombotic therapeutic targets with reduced bleeding risk. We summarize some recently emerging examples of agents with antithrombotic activities that seem to spare hemostasis...
February 21, 2018: Blood
https://www.readbyqxmd.com/read/29465600/a-novel-endobronchial-approach-to-massive-hemoptysis-complicating-silicone-y-stent-placement-for-tracheobronchomalacia-a-case-report
#4
Changwan Ryu, Daniel Boffa, Kyle Bramley, Margaret Pisani, Jonathan Puchalski
RATIONALE: Airway stabilization for severe, symptomatic tracheobronchomalacia (TBM) may be accomplished by silicone Y-stent placement. Common complications of the Y-stent include mucus plugging and granulation tissue formation. PATIENT CONCERNS: We describe a rare case of massive hemoptysis originating from a silicone Y-stent placed for TBM. DIAGNOSES: An emergent bronchoscopy showed an actively bleeding, pulsatile vessel at the distal end of the left bronchial limb of the Y-stent...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465250/continuous-esomeprazole-infusion-versus-bolus-administration-and-second-look-endoscopy-for-the-prevention-of-rebleeding-in-children-with-a-peptic-ulcer
#5
Oana Belei, Laura Olariu, Maria Puiu, Cristian Jinca, Cristina Dehelean, Tamara Marcovici, Otilia Marginean
INTRODUCTION: the majority of studies of acute gastrointestinal bleeding in children are retrospective, focusing on therapeutic endoscopy. Previous studies performed in adult patients have demonstrated that both scheduled second look endoscopy and high dose continuous omeprazole infusion are effective in the prevention of peptic ulcer rebleeding. The aim of this study was to compare the efficacy of these two strategies using esomeprazole for the prevention of rebleeding following primary endoscopic hemostasis in children with peptic ulcers...
February 21, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29464888/postoperative-cytological-findings-from-the-use-of-the-integran-microfibrillar-collagen-hemostatic-matrix-in-conization
#6
Shinji Toyoda, Hiroshi Okada, Hideo Tsujino, Yoshinori Takeda, Atsushi Sugiura, Yoshio Itani, Tsunekazu Kita, Eiwa Ishida
The Integran microfibrillar collagen hemostatic matrix is one form of microfibrillar collagen hemostat. This form has a sheet-type structure and has explicitly been used in Japan. In gynecology, this sheet-type matrix has helped effect uterine surface hemostasis, especially in myomectomy and cervical conization. However, cytotechnologists and pathologists have overlooked the foreign materials used for conization in postoperative cervical cytology. We report two cases describing the characteristic cervical cytology findings when Integran was used in conization...
February 21, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29464566/conformational-equilibrium-of-human-platelet-integrin-investigated-by-three-dimensional-electron-cryo-microscopy
#7
Dorit Hanein, Niels Volkmann
Integrins are bidirectional transmembrane receptors that play central roles in hemostasis and arterial thrombosis. They have been subject to structural studies for many years, in particular using X-ray crystallography, nuclear magnetic resonance spectroscopy, and two-dimensional negative stain electron microscopy. Despite considerable progress, a full consensus on the molecular mechanism of integrin activation is still lacking. Three-dimensional reconstructions of full-length human platelet integrin αIIb β3 in lipid-bilayer nanodiscs obtained by electron cryo-microscopy and single-particle reconstruction have shed new light on the activation process...
2018: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/29463696/genetic-rescue-of-lineage-balanced-blood-cell-production-reveals-a-crucial-role-for-stat3-antiinflammatory-activity-in-hematopoiesis
#8
Huiyuan Zhang, Haiyan S Li, Emily J Hillmer, Yang Zhao, Taylor T Chrisikos, Hongbo Hu, Xiao Wu, Erika J Thompson, Karen Clise-Dwyer, Karen A Millerchip, Yue Wei, Nahum Puebla-Osorio, Saakshi Kaushik, Margarida A Santos, Bin Wang, Guillermo Garcia-Manero, Jing Wang, Shao-Cong Sun, Stephanie S Watowich
Blood cell formation must be appropriately maintained throughout life to provide robust immune function, hemostasis, and oxygen delivery to tissues, and to prevent disorders that result from over- or underproduction of critical lineages. Persistent inflammation deregulates hematopoiesis by damaging hematopoietic stem and progenitor cells (HSPCs), leading to elevated myeloid cell output and eventual bone marrow failure. Nonetheless, antiinflammatory mechanisms that protect the hematopoietic system are understudied...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29463570/correction-enzymatic-lipid-oxidation-by-eosinophils-propagates-coagulation-hemostasis-and-thrombotic-disease
#9
Stefan Uderhardt, Jochen A Ackermann, Tobias Fillep, Victoria J Hammond, Johann Willeit, Peter Santer, Manuel Mayr, Markus Biburger, Meike Miller, Katie R Zellner, Konstantin Stark, Alexander Zarbock, Jan Rossaint, Irene Schubert, Dirk Mielenz, Barbara Dietel, Dorette Raaz-Schrauder, Cihan Ay, Thomas Gremmel, Johannes Thaler, Christian Heim, Martin Herrmann, Peter W Collins, Gernot Schabbauer, Nigel Mackman, David Voehringer, Jerry L Nadler, James J Lee, Steffen Massberg, Manfred Rauh, Stefan Kiechl, Georg Schett, Valerie B O'Donnell, Gerhard Krönke
No abstract text is available yet for this article.
February 20, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29462813/hemostatic-efficacy-and-safety-of-the-novel-medical-adhesive-mar-vivo-107-in-a-rabbit-liver-resection-model
#10
Kenji Fukushima, Hirokazu Tanaka, Pramod Kadaba Srinivasan, Kerstin Pawlowsky, Babette Kögel, Shinji Uemoto, Yonson Ku, René H Tolba
BACKGROUND: Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue. METHODS: Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (n = 10), fibrin glue (n = 10), and saline groups (n = 10). After standardized partial liver resection was performed, each agent was immediately applied to the wound area...
February 20, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29462082/a-novel-minimally-invasive-approach-to-assure-hemostasis-for-intercostal-bleeding-after-trauma
#11
Habeeba Park, Katherine Florecki, Nathan Schmoekel, Joseph DuBose, Deborah Stein, Thomas Scalea
No abstract text is available yet for this article.
February 17, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29461372/a-standard-operating-procedure-of-clean-and-fast-craniotomy-without-application-of-raney-clips
#12
Songyu Chen, Xin Zhang, Fuxin Lin, Shujun Xu, Xingang Li, Xiangyu Ma
Clean and fast craniotomy and closure (CAC) is a fundamental part of modern microneurosurgery, and is an essential technique that young neurosurgeons shall master. The hemostatic instruments of CAC have evolved from forceps to raney clips. Thanks to the wide application of bipolar coagulation, local infiltration anesthesia combined with cauterization is become an effective method of hemostasis. The authors worked out a standard operating procedure (SOP) of CAC assisted by fishhooks without the application of raney clips...
February 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29460388/efficacy-safety-and-pharmacokinetics-of-a-new-high-purity-factor-x-concentrate-in-women-and-girls-with-hereditary-factor-x-deficiency
#13
Roshni Kulkarni, Andra H James, Miranda Norton, Amy Shapiro
BACKGROUND: A high-purity, plasma-derived factor X concentrate (pdFX) is approved to treat hereditary factor X deficiency, an autosomal recessive disorder. OBJECTIVE: Post hoc assessment of pdFX pharmacokinetics, safety, and efficacy in women and girls with hereditary factor X deficiency. PATIENTS/METHODS: Subjects aged ≥12 years with moderate/severe factor X deficiency (plasma factor X activity <5 IU/dL) received on-demand or preventive pdFX (25 IU/kg) for ≤2 years...
February 20, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29457430/-clinical-effect-of-superselective-arterial-embolization-for-the-treatment-of-massive-haemorrhage-from-pelvic-fracture
#14
Zheng-Qiu Lin, Xiu-Zhi Ye, Wei-Liang Wang, Guo-Qing Zhu, Bing-Ju Xie, Liang-le Liu
OBJECTIVE: To investigate feasibility and curative effect of superselective arterial embolization for the treatment of massive haemorrhage from pelvic fracture. METHODS: From March 2008 to February 2016, clinical data of 65 patients with massive haemorrhage from pelvic fracture were collected and analyzed, and patients were divided into non-embolic and embolic group according to whether perform vascular thrombosis. Thirty-three patients were in non-embolic group including 26 males and 7 females aged from 21 to 64 years old with an average of(39...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457148/platelets-at-the-vascular-interface
#15
Wolfgang Bergmeier, Lucia Stefanini
In this brief review paper, we will summarize the State-of-the-Art on how platelet reactivity is regulated in circulation and at sites of vascular injury. Our review discusses recent and ongoing work, presented at this year's International Society on Thrombosis and Haemostasis (ISTH) meeting, on the role of platelets in (1) classical hemostasis at sites of mechanical injury, and (2) the maintenance of vascular integrity at sites of inflammation.
January 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29456511/p2y-12-receptors-in-tumorigenesis-and-metastasis
#16
REVIEW
Patrizia Ballerini, Melania Dovizio, Annalisa Bruno, Stefania Tacconelli, Paola Patrignani
Platelets, beyond their role in hemostasis and thrombosis, may sustain tumorigenesis and metastasis. These effects may occur via direct interaction of platelets with cancer and stromal cells and by the release of several platelet products. Platelets and tumor cells release several bioactive molecules among which a great amount of adenosine triphosphate (ATP) and adenosine diphosphate (ADP). ADP is also formed extracellularly from ATP breakdown by the ecto-nucleoside-triphosphate-diphosphohydrolases. Under ATP and ADP stimulation the purinergic P2Y1 receptor (R) initiates platelet activation followed by the ADP-P2Y12 R-mediated amplification...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29456232/seizure-induced-by-tranexamic-acid-in-a-patient-with-chronic-kidney-disease-on-maintenance-dialysis
#17
Kar Wah Fuah, Christopher T S Lim, Daniel C L Pang, Jin Shyan Wong
Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to achieve hemostasis. However, there have been a few case reports suggesting that high-dose intravenous TXA has epileptogenic property. In patients with renal impairment, even administering the usual recommended dose of TXA can induce seizure episodes. We present here a patient on hemodialysis who developed seizures after receiving two doses of TXA over 5 h period.
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456209/assessment-of-prevalence-and-clinical-outcome-of-frailty-in-an-elderly-predialysis-cohort-using-simple-tools
#18
Hatem Ali, Tarek Abdelaziz, Fatima Abdelaal, Jyoti Baharani
The relationship between frailty and chronic kidney disease in elderly population has been recognized; however, studies concentrating on frailty in predialysis patients are limited. For nephrologists, the recognition of frailty is important as it has impact on decisions on the choice of dialysis modality and sometimes on whether dialysis is indeed in the patients' best interests. Many of the tools for routine assessment of frailty are not easily applicable to those clinicians not practicing elderly care medicine...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455488/-analysis-of-clinical-effects-of-absorbable-hemostatic-fluid-gelatin-and-absorbable-gelatin-sponge-on-the-hemostasis-during-operation-of-unilateral-open-door-cervical-expansive-laminoplasty
#19
Guang-Zhou Li, Ying Hong, Hao Liu, Li-Tai Ma, Yi Yang, Chen Ding, Bei-Yu Wang, Hua Chen
OBJECTIVE: To compare the hemostatic effect between absorbable hemostatic fluid gelatin (HFG) and absorbable gelatin sponge(GS) during operation of unilateral open-door cervical expansive laminoplasty. METHODS: The clinical data of 83 patients underwent unilateral open-door cervical expansive laminoplasty from February 2014 to May 2016 were retrospectively analyzed. According to the used hemostatic materials, patients were divided into two groups. In HFG group, there were 30 males and 11 females, ranging in age from 29 to 81 years, with an average of(55...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455413/influence-of-abo-blood-type-on-the-outcome-after-non-aneurysmal-subarachnoid-hemorrhage
#20
Daniel Dubinski, Sae-Yeon Won, Bedjan Behmanesh, Sepide Kashefiolasl, Christof Geisen, Volker Seifert, Christian Senft, Juergen Konczalla
BACKGROUND: In patients with non-aneurysmal subarachnoid hemorrhage (NA-SAH), the etiology is unknown and the bleeding source remains unidentified. However, the ABO blood type system has a profound role in patient's hemostasis and thrombosis. To date, the aspect of ABO blood type in incidence, clinical course, and outcome after NA-SAH has not been investigated. METHODS: In this retrospective analysis, 81 patients with non-traumatic and non-aneurysmal subarachnoid hemorrhage treated between 2010 and 2014 at the author's institution were included...
February 17, 2018: Acta Neurochirurgica
keyword
keyword
5665
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"