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Hemostasis

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https://www.readbyqxmd.com/read/29052850/curcumin-hemostasis-thrombosis-and-coagulation
#1
REVIEW
Faeze Keihanian, Amin Saeidinia, Ramin Khameneh Bagheri, Thomas P Johnston, Amirhossein Sahebkar
Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particularly in hemostasis and the coagulation process, as well as altering platelet function tests and some coagulation parameters. Curcumin is a polyphenol derived from the Curcuma longa plant and has been used extensively in complementary and alternative medicine, as it is nontoxic and safe with various therapeutic properties...
October 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29052833/emergency-endovascular-treatment-of-a-ruptured-external-carotid-artery-pseudoaneurysm-caused-by-a-cervical-stab-wound-a-case-report-and-literature-review
#2
Junya Tsurukiri, Eitaro Okumura, Hiroshi Yamanaka, Hiroyuki Jimbo, Akira Hoshiai
The formation of external carotid artery (ECA) pseudoaneurysms caused by stab wounds is a rare vascular anomaly. Although the surgical exploration of the ECA segment is the standard treatment, endovascular treatment (EVT) can be considered if there is difficulty in identifying the source of bleeding in the injured regions that are difficult to operatively access. Here we treated a young patient who had hemorrhagic instability with hemorrhage-induced coagulopathy caused by a zone III cervical stab wound with a pseudoaneurysm from the main trunk of the ECA; the patient underwent EVT and successful hemostasis...
September 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29052682/probing-blood-cell-mechanics-of-hematologic-processes-at-the-single-micron-level
#3
Jordan C Ciciliano, Reza Abbaspour, Julia Woodall, Caroline Wu, Muhannad S Bakir, Wilbur A Lam
Blood cells circulate in a dynamic fluidic environment, and during hematologic processes such as hemostasis, thrombosis, and inflammation, blood cells interact biophysically with a myriad of vascular matrices-blood clots and the subendothelial matrix. While it is known that adherent cells physiologically respond to the mechanical properties of their underlying matrices, how blood cells interact with their mechanical microenvironment of vascular matrices remains poorly understood. To that end, we developed microfluidic systems that achieve high fidelity, high resolution, single-micron PDMS features that mimic the physical geometries of vascular matrices...
October 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29052135/hepatitis-c-virus-associated-cancers
#4
Zhigang Yi, Zhenghong Yuan
Most hepatitis C virus (HCV) infection results in persistent infection. Significant portion of chronic HCV-infected patients develop hepatocellular carcinoma (HCC). Chronic hepatitis C is also associated with extrahepatic manifestations, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes, and neurological disorders. The molecular mechanisms of how HCV infection causes liver cancer are largely unknown. HCV replication or viral proteins may perturb cellular hemostasis and induce the generation of reactive oxygen species (ROS); viral components or viral replication products act as agonist to trigger innate immune response and cause chronic inflammation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29044931/a-novel-technique-for-simultaneous-hemostasis-of-ipsilateral-radial-and-ulnar-artery-access-sites
#5
Jonathan S Roberts, Jianli Niu
With the increased use of transradial artery access (TRA) for diagnostic and coronary interventional procedures, crossover to the ipsilateral ulnar artery after TRA failure is being reported more frequently. A major challenge with ipsilateral transradial and ulnar artery access is achieving efficient patent hemostasis of both the radial and ulnar arteries at the completion of the procedure. In this report, we describe two cases of failed TRA with subsequent ipsilateral ulnar artery access. A novel and practical technique of simultaneous patent hemostasis of both the ipsilateral radial and ulnar artery access sites is described, using a QuikClot(®) Radial(®) hemostasis pad and a TR Band(®) ...
October 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29044006/clinical-efficacy-of-cryotherapy-combined-with-interferon-in-the-treatment-of-chronic-cervicitis-complicated-with-hpv-infection
#6
Yuehui Su, Mengzhen Zhang, Weiwei Zhang, Huirong Shi
This paper aims to investigate the clinical curative effect and adverse reactions of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. 100 cases diagnosed with chronic cervicitis complicated with HPV infection from August 2014 to August 2015 in our hospital were selected and randomly divided into observation group (50 cases) and control group (50 cases). The preoperative and postoperative HPV-DNA changes were observed, and the vaginal discharge, time of decrustation and hemostasis, HPV negative conversion ratio and clinical efficacy were compared, to record the adverse reactions during treatment...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29043114/expression-of-stk11-gene-and-its-promoter-activity-in-mcf-control-and-cancer-cells
#7
Asma Alkaf, Abdulaziz Al-Jafari, Tanveer A Wani, Somaya Alqattan, Seema Zargar
Serine/threonine kinase gene (STK11) is identified as tumor suppressor gene whose mutation can lead to Peutz-Jeghers syndrome (PJS). STK11 is emerging as a multifunctional protein, it activates 14 different AMP-activated protein kinase (AMPK) family members, important in the regulation of cell polarity, cell cycle arrest, energy and hemostasis. Present study was designed to evaluate STK11 mRNA expression in MCF-7 cancer and MCF-10 normal breast cells lines. mRNA expression was studied by real-time PCR. Further, human STK11 promoter construct was fused to a luciferase reporter and transfected into both MCF-7 and MCF-10 cells to identify the promoter activity in these cells...
December 2017: 3 Biotech
https://www.readbyqxmd.com/read/29042825/antithrombotics-in-trauma-management-strategies-in-the-older-patients
#8
REVIEW
Henna Wong, Nicola Lovett, Nicola Curry, Ku Shah, Simon J Stanworth
The ageing population has resulted in a change in the demographics of trauma, and older adult trauma now accounts for a growing number of trauma admissions. The management of older adult trauma can be particularly challenging, and exhibits differences to that of the younger age groups affected by trauma. Frailty syndromes are closely related with falls, which are the leading cause of major trauma in older adults. Comorbid disease and antithrombotic use are more common in the older population. Physiological changes that occur with ageing can alter the expected clinical presentation of older persons after injury and their susceptibility to injury...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29042697/vaginoplasty-with-a-pudendal-groin-flap-in-male-to-female-transsexuals
#9
Yuko Mukai, Toshiyuki Watanabe, Morito Sugimoto, Yoshihiro Kimata, Yuzaburo Namba
Many vaginoplasty techniques have been introduced to improve the outcomes of sex reassignment surgery for male-to-female transsexuals. Some vaginoplasty patients still require additional skin grafts, making dilation mandatory to overcome shrinkage. We developed a new vaginoplasty method (called the "pudendal-groin flap") that uses pudendal-groin flaps. One of this procedure's advantages is that skin grafts are unnecessary, even for patients with small penises and scrotums. We introduce the procedure here and describe our evaluation of its utility...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29039918/bio-inspired-antioxidant-defense-system-constructed-by-antioxidants-eluting-electrospun-f127-based-fibers
#10
Haozheng Wang, Xiaodong Xu, Runhai Chen, Jiruo Zhao, Lele Cui, Guangkuo Sheng, Qiang Shi, Shing-Chung Wong, Jinghua Yin
Cells were continuously exposed to oxidative damage by overproduction of reactive oxygen species (ROS) when they contacted implanted biomaterials. The strategy to prevent cells from oxidative injures remains challenge. Inspired by the antioxidant defense system of cells, we constructed a biocompatible and ROS-responsive architecture on the substrate of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS). The strategy was based on fabrication of 3D architectures through reactive electrospinning of mixture including SEBS, acylated Pluronic F127, copolymer of poly(ethylene glycol) diacrylate and 1,2-ethanedithiol (PEGDA-EDT) and antioxidants (AA-2G), and ROS-triggered release of AA-2G from microfibers to detoxify the excess ROS...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29039097/in-vitro-assessment-of-nanoparticle-effects-on-blood-coagulation
#11
Timothy M Potter, Jamie C Rodriguez, Barry W Neun, Anna N Ilinskaya, Edward Cedrone, Marina A Dobrovolskaia
Blood clotting is a complex process which involves both cellular and biochemical components. The key cellular players in the blood clotting process are thrombocytes or platelets. Other cells, including leukocytes and endothelial cells, contribute to clotting by expressing the so-called pro-coagulant activity (PCA) complex on their surface. The biochemical component of blood clotting is represented by the plasma coagulation cascade, which includes plasma proteins also known as coagulation factors. The coordinated interaction between platelets, leukocytes, endothelial cells, and plasma coagulation factors is necessary for maintaining hemostasis and for preventing excessive bleeding...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29035656/clinical-laboratory-and-hemostatic-findings-in-cats-with-naturally-occurring-sepsis
#12
Sigal Klainbart, Limor Agi, Tali Bdolah-Abram, Efrat Kelmer, Itamar Aroch
OBJECTIVE To characterize clinical and laboratory findings in cats with naturally occurring sepsis, emphasizing hemostasis-related findings, and evaluate these variables for associations with patient outcomes. DESIGN Prospective, observational, clinical study. ANIMALS 31 cats with sepsis and 33 healthy control cats. PROCEDURES Data collected included history; clinical signs; results of hematologic, serum biochemical, and hemostatic tests; diagnosis; and outcome (survival vs death during hospitalization or ≤ 30 days after hospital discharge)...
November 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29034240/dark-chocolate-opportunity-for-an-alliance-between-medical-science-and-the-food-industry
#13
Ivan M Petyaev, Yuriy K Bashmakov
Dark chocolate (DC) was originally introduced in human nutrition as a medicinal product consumable in a liquid form. Century-long efforts of food industry transformed this hardly appealing product into a valuable modern culinary delight with clear predominance of confectionery brands of DC on the market. However, current epidemiological data as well as multiple experimental and clinical observations reveal that DC consumption may have a profound effect on cardiovascular, central nervous systems, hemostasis, and lipid metabolism...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29032938/the-jak-stat-signaling-pathway-and-photobiomodulation-in-chronic-wound-healing
#14
Sandy W Jere, Heidi Abrahamse, Nicolette N Houreld
Wound healing is a physiological process that occurs in overlapping phases namely hemostasis, inflammation, proliferation, and remodeling. Chronic wounds fail to proceed through these reparative processes to achieve the functional integrity within the expected time. Wound healing relies upon growth factors and cytokines for the precise and accurate regulation of cellular responses. These are achieved through the use of complex growth factor/cytokine induced signaling pathways. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway transmits extracellular signals to the nucleus for the transcription of genes involved in proliferation and differentiation, to name but a few...
October 6, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29031658/randomized-controlled-pilot-study-of-the-preoperative-use-of-brimonidine-0-33-topical-gel-for-hemostasis-in-mohs-micrographic-surgery
#15
Edward Chen, Raj Ajay Patel, Young Jin Kwak, Conway C Huang
BACKGROUND: Brimonidine topical gel may be useful in cutaneous surgical procedures because of its vasoconstricting properties. OBJECTIVE: Assess the hemostatic effect of topically applied brimonidine in patients being treated with anticoagulants and undergoing Mohs micrographic surgery (MMS). METHODS: Subjects undergoing MMS were randomly assigned to the control (n = 10) or study arm (n = 14). Controls received standard-of-care MMS, whereas the study arm received the same and preoperative application of brimonidine...
October 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29028293/a-large-case-series-on-surgical-outcomes-in-congenital-fxiii-deficiency-patients-in-iran
#16
Majid Naderi, Sezaneh Haghpanah, Ghasem Miri-Aliabad, Hakimeh Tavosi, Mehran Karimi
BACKGROUND: The lack of accepted standardized surgical guidelines leads to dependence on the treating physicians' and centers' experiences. AIM: Our aim is to evaluate the surgical outcomes on a large group of congenital FXIII deficiency (FXIIID) patients. METHODS: A case series study was conducted on congenital FXIIID patients in two major referral centers located in Iran from 2010 to 2016 prior to surgery. All patients were on prophylaxis using plasma factor XIII concentrate (10 U kg(-1) , every 28 days) except three patients...
October 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29027741/recommendations-for-standardized-risk-factor-definitions-in-pediatric-hospital-acquired-venous-thromboembolism-to-inform-future-prevention-trials-communication-from-the-ssc-of-the-isth
#17
B R Branchford, A Mahajerin, L Raffini, E Chalmers, C H van Ommen, A K C Chan, N A Goldenberg
No abstract text is available yet for this article.
September 16, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29027381/evaluation-of-a-new-energy-device-for-parenchymal-transection-in-laparoscopic-liver-resection
#18
Amr Badawy, Satoru Seo, Rei Toda, Hiroaki Fuji, Takamichi Ishii, Kojiro Taura, Kentaro Yasuchika, Toshimi Kaido, Shinji Uemoto
INTRODUCTION: THUNDERBEAT (TB) is a novel device that uses both ultrasonic and advanced bipolar energies for hemostasis. Several recent human studies have proved the safety and efficacy of TB in different surgical procedures, but there have been no similar studies about its efficacy in hepatic parenchymal transection. Therefore, the aim of the study was to assess the safety and efficacy of the TB device in laparoscopic liver resection. METHODS: This retrospective study compared TB and ultrasonic Harmonic devices in 80 patients who underwent laparoscopic liver resection from 2010 to 2016 in our institution...
October 12, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29027310/ruptured-external-iliac-artery-pseudoaneurysm-following-surgery-for-ovarian-cancer-a-case-report-and-literature-review
#19
Mitsutake Yano, Kaei Nasu, Harunobu Matsumoto, Tomoko Hirakawa, Shinji Miyamoto, Hisashi Narahara
Ruptured pseudoaneurysm following pelvic surgery is a rare and fatal complication. Because of its rarity, existing evidence is limited to a small case series. A 60-year-old woman underwent staging laparotomy, including pelvic and para-aortic lymphadenectomy, for ovarian cancer. On the 11th day, the patient developed a sudden lumbar pain and loss of consciousness, which resulted in a state of shock. She was diagnosed as having a pelvic abscess and ruptured external iliac artery pseudoaneurysm. We performed ligation of the external iliac artery to restrain hemorrhage and femoro-femoral artery bypass to prevent infection, which saved the patient's life...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29026409/hemostasis-in-hypothyroidism-and-autoimmune-thyroid-disorders
#20
REVIEW
Arash Ordookhani, Kenneth D Burman
CONTEXT: There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders. EVIDENCE ACQUISITION: A comprehensive literature search was conducted employing MEDLINE database...
April 2017: International Journal of Endocrinology and Metabolism
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