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verbal auditory hallucinations

Iris E Sommer, Hidde Kleijer, Kenneth Hugdahl
PURPOSE OF REVIEW: Hallucinations are common and often stressful experiences, occurring in all sensory modalities. They frequently complicate many disorders or situations, such as Parkinson's disease, schizophrenia, hearing or vision loss, intoxications and delirium. Although psychoeducation, coping techniques and psychotherapy may be broadly applicable, they do not address a specific underlying brain mechanism. Pharmacotherapy may effectively alleviate hallucinations if the corresponding mechanism is present, whereas in its absence, may only cause harmful side effects...
March 9, 2018: Current Opinion in Psychiatry
Ryu-Ichiro Hashimoto, Takashi Itahashi, Rieko Okada, Sayaka Hasegawa, Masayuki Tani, Nobumasa Kato, Masaru Mimura
Abnormalities in functional brain networks in schizophrenia have been studied by examining intrinsic and extrinsic brain activity under various experimental paradigms. However, the identified patterns of abnormal functional connectivity (FC) vary depending on the adopted paradigms. Thus, it is unclear whether and how these patterns are inter-related. In order to assess relationships between abnormal patterns of FC during intrinsic activity and those during extrinsic activity, we adopted a data-fusion approach and applied partial least square (PLS) analyses to FC datasets from 25 patients with chronic schizophrenia and 25 age- and sex-matched normal controls...
2018: NeuroImage: Clinical
Ri-Xing Jing, Shen Li, Xin-Jun Zhang, Jing Long, Tian-Hong Zhou, Chuan-Jun Zhuo
No abstract text is available yet for this article.
March 20, 2018: Chinese Medical Journal
Won Hee Lee, Nigel I Kennedy, Marom Bikson, Sophia Frangou
We use auditory verbal hallucinations (AVH) to illustrate the challenges in defining and assessing target engagement in the context of transcranial direct current stimulation (tDCS) for psychiatric disorders. We defined the target network as the cluster of regions of interest (ROIs) that are consistently implicated in AVH based on the conjunction of multimodal meta-analytic neuroimaging data. These were prescribed in the New York Head (a population derived model) and head models of four single individuals. We appraised two potential measures of target engagement, tDCS-induced peak electric field strength and tDCS-modulated volume defined as the percentage of the volume of the AVH network exposed to electric field magnitude stronger than the postulated threshold for neuronal excitability...
2018: Frontiers in Psychiatry
Marion Psomiades, Marine Mondino, Clara Fonteneau, Remy Bation, Frederic Haesebaert, Marie-Françoise Suaud-Chagny, Jerome Brunelin
Auditory verbal hallucinations (AVH) in patients with schizophrenia are linked to abnormalities within a large cerebral network including frontal and temporal regions. Whilst abnormalities of frontal speech production and temporal speech perception regions have been extensively studied, alterations of the dorsolateral prefrontal cortex (DLPFC), a region critically involved in the pathophysiology of schizophrenia, have rarely been studied in relation to AVH. Using 1.5 T proton magnetic resonance spectroscopy, this study examined the relationship between right and left DLPFCs N-AcetylAspartate (NAA) levels and the severity of AVH in patients with schizophrenia...
March 7, 2018: Scientific Reports
Alyssa Jongeneel, Dorien Scheffers, Nynke Tromp, Chani Nuij, Philippe Delespaul, Heleen Riper, Mark van der Gaag, David van den Berg
INTRODUCTION: Auditory verbal hallucinations (AVH) are prevalent experiences that can induce distress and impede social functioning. While most voice hearers benefit from antipsychotic medication or cognitive-behavioural therapy, additional effective interventions are needed to reduce the burden of experiencing AVH. 'Temstem' is an easily accessible and useable smartphone application that was developed by designers in close cooperation with voice hearers and experts. By using language games, Temstem aims to reduce distress and improve social functioning...
March 6, 2018: BMJ Open
Olivier Percie du Sert, Stéphane Potvin, Olivier Lipp, Laura Dellazizzo, Mélanie Laurelli, Richard Breton, Pierre Lalonde, Kingsada Phraxayavong, Kieron O'Connor, Jean-François Pelletier, Tarik Boukhalfi, Patrice Renaud, Alexandre Dumais
Schizophrenia is a chronic and severe mental illness that poses significant challenges. While many pharmacological and psychosocial interventions are available, many treatment-resistant schizophrenia patients continue to suffer from persistent psychotic symptoms, notably auditory verbal hallucinations (AVH), which are highly disabling. This unmet clinical need requires new innovative treatment options. Recently, a psychological therapy using computerized technology has shown large therapeutic effects on AVH severity by enabling patients to engage in a dialogue with a computerized representation of their voices...
February 24, 2018: Schizophrenia Research
Rixing Jing, Jiangjie Huang, Deguo Jiang, Xiaodong Lin, Xiaolei Ma, Hongjun Tian, Jie Li, Chuanjun Zhuo
Schizophrenia is associated with widespread and complex cerebral blood flow (CBF) disturbance. Auditory verbal hallucinations (AVH) and insight are the core symptoms of schizophrenia. However, to the best of our knowledge, very few studies have assessed the CBF characteristics of the AVH suffered by schizophrenic patients with and without insight. Based on our previous findings, Using a 3D pseudo-continuous ASL (pcASL) technique, we investigated the differences in AVH-related CBF alterations in schizophrenia patients with and without insight...
January 23, 2018: Oncotarget
Thiebes Stephanie, Steinmann Saskia, Curic Stjepan, Polomac Nenad, Andreou Christina, Eichler Iris-Carola, Eichler Lars, Zöllner Christian, Gallinat Jürgen, Leicht Gregor, Mulert Christoph
Auditory verbal hallucinations (AVH) are a common positive symptom of schizophrenia. Excitatory-to-inhibitory (E/I) imbalance related to disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism underlying altered connectivity and AVH in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist, on glutamate-related mechanisms underlying interhemispheric gamma-band connectivity, conscious auditory perception during dichotic listening (DL), and the emergence of auditory verbal distortions and hallucinations (AVD/AVH) in healthy volunteers...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Natasza D Orlov, Vincent Giampietro, Owen O'Daly, Sheut-Ling Lam, Gareth J Barker, Katya Rubia, Philip McGuire, Sukhwinder S Shergill, Paul Allen
Neurocognitive models and previous neuroimaging work posit that auditory verbal hallucinations (AVH) arise due to increased activity in speech-sensitive regions of the left posterior superior temporal gyrus (STG). Here, we examined if patients with schizophrenia (SCZ) and AVH could be trained to down-regulate STG activity using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF). We also examined the effects of rtfMRI-NF training on functional connectivity between the STG and other speech and language regions...
February 12, 2018: Translational Psychiatry
Xiaoling Zhang, Jie Gao, Feng Zhu, Wei Wang, Yajuan Fan, Qingyan Ma, Xiancang Ma, Jian Yang
This study aims to explore whether auditory verbal hallucinations (AVH) in schizophrenia are associated with the white matter abnormalities in tracts connecting language, auditory and memory/limbic networks in first-episode and chronic schizophrenia patients. 21 first-episode (FE-AVH) and 12 chronic (chronic-AVH group) patients who suffered from auditory verbal hallucinations and 26 healthy controls (HC group) were enrolled. Diffusion tensor imaging with tract-based spatial statistics was performed to assess the white matter changes between the two patient groups and HC group...
January 25, 2018: Psychiatry Research
Lucia Visser, Igne Sinkeviciute, Iris E Sommer, Josef J Bless
Auditory verbal hallucinations complicate many psychiatric disorders. Antipsychotic medication is effective in the majority, but a significant minority experiences high burden from resistant hallucinations. Here, we aim to improve executive control, in an attempt to decrease burden from hallucinations. We describe the use of a cognitive trainings app by a young woman with highly resistant hallucinations. With modest training, a significant decrease in the duration of hallucinations was reached. Possibilities of this training technique are discussed...
February 2018: Scandinavian Journal of Psychology
Josef J Bless, Frank Larøi, Julien Laloyaux, Kristiina Kompus, Bodil Kråkvik, Einar Vedul-Kjelsås, Anne Martha Kalhovde, Kenneth Hugdahl
Understanding what happens at first onset of auditory verbal hallucinations (AVHs) is extremely important on a clinical and theoretical level. Previous studies have only focused on age with regard to first onset of AVHs. In the current epidemiological study, we examined a number of aspects relating to first onset of AVHs, such as the role of adverse life events at first onset of AVHs on symptom severity and general mental health. For this purpose, we compared participants who reported adverse life events at first onset of AHVs (adverse-trigger group; N = 76) to those that did not report any specific events at first onset of AVHs (no-adverse-trigger group; N = 59) on a large array of variables...
December 24, 2017: Psychiatry Research
Katharina M Kubera, Philipp A Thomann, Dusan Hirjak, Anja Barth, Fabio Sambataro, Nenad Vasic, Nadine D Wolf, Karel Frasch, R Christian Wolf
In schizophrenia temporal cortical volume loss differs between patients presenting with persistent auditory verbal hallucinations (pAVH) in contrast to those without hallucinatory symptoms (nAVH). However, it is unknown whether this deficit reflects a neural signature of neurodevelopmental origin or if abnormal temporal cortical volume is reflective of factors which may be relevant at later stages of the disorder. Here, we tested the hypothesis that local gyrification index (LGI) in regions of the temporal cortex differs between patients with pAVH (n=10) and healthy controls (n=14), and that abnormal temporal LGI discriminates between pAVH and nAVH (n=10)...
January 2, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
A Bose, V Shivakumar, H Chhabra, R Parlikar, V S Sreeraj, D Dinakaran, J C Narayanaswamy, G Venkatasubramanian
Persistent auditory verbal hallucination is a clinically significant problem in schizophrenia. Recent studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in treatment. An optimised version of tDCS, namely high-definition tDCS (HD-tDCS), uses smaller electrodes arranged in a 4x1 ring configuration and may offer more focal and predictable neuromodulation than conventional tDCS. This case report illustrates the feasibility and clinical utility of add-on HD-tDCS over the left temporoparietal junction in a 4x1 ring configuration to treat persistent auditory verbal hallucination in schizophrenia...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
Christian Plewnia, Bettina Brendel, Tobias Schwippel, Peter Martus, Joachim Cordes, Alkomiet Hasan, Andreas J Fallgatter
Auditory verbal hallucinations (AH) are core symptoms of schizophrenia. They are often severely distressing and refractory to therapy. Their perception is associated with increased activity in temporoparietal areas of the brain. Repetitive transcranial magnetic stimulation (rTMS) can reduce focal brain hyperactivity and has been shown to ameliorate AH. However, controlled multicenter clinical trials are still missing, effect sizes are moderate, and the treatment with rTMS is time consuming. Continuous theta burst stimulation (cTBS) is a quicker and potentially more effective technique to reduce cortical hyperactivity...
December 9, 2017: European Archives of Psychiatry and Clinical Neuroscience
Antonio Fernández-Caballero, Elena Navarro, Patricia Fernández-Sotos, Pascual González, Jorge J Ricarte, José M Latorre, Roberto Rodriguez-Jimenez
This perspective paper faces the future of alternative treatments that take advantage of a social and cognitive approach with regards to pharmacological therapy of auditory verbal hallucinations (AVH) in patients with schizophrenia. AVH are the perception of voices in the absence of auditory stimulation and represents a severe mental health symptom. Virtual/augmented reality (VR/AR) and brain computer interfaces (BCI) are technologies that are growing more and more in different medical and psychological applications...
2017: Frontiers in Neuroinformatics
S Trevor Taylor, Harleen Chhabra, Vanteemar S Sreeraj, Venkataram Shivakumar, Sunil V Kalmady, Ganesan Venkatasubramanian
Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%-80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%-30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects...
September 2017: Indian Journal of Psychological Medicine
Tom Kj Craig, Mar Rus-Calafell, Thomas Ward, Julian P Leff, Mark Huckvale, Elizabeth Howarth, Richard Emsley, Philippa A Garety
BACKGROUND: A quarter of people with psychotic conditions experience persistent auditory verbal hallucinations, despite treatment. AVATAR therapy (invented by Julian Leff in 2008) is a new approach in which people who hear voices have a dialogue with a digital representation (avatar) of their presumed persecutor, voiced by the therapist so that the avatar responds by becoming less hostile and concedes power over the course of therapy. We aimed to investigate the effect of AVATAR therapy on auditory verbal hallucinations, compared with a supportive counselling control condition...
January 2018: Lancet Psychiatry
Simon McCarthy-Jones
BACKGROUND: Whilst evidence is mounting that childhood sexual abuse (CSA) can be a cause of auditory verbal hallucinations (AVH), it is unclear what factors mediate this relation. Recent evidence suggests that post-traumatic symptomatology may mediate the CSA-AVH relation in clinical populations, although this hypothesis has not yet been tested in the general population. There is also reason to believe that obsessive ideation could mediate the CSA-AVH relation. AIMS: To test for evidence to falsify the hypotheses that post-traumatic symptomatology, obsessions, compulsions, anxiety and depression mediate the relation between CSA and AVH in a general population sample...
November 9, 2017: Behavioural and Cognitive Psychotherapy
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