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verbal auditory hallucinations

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https://www.readbyqxmd.com/read/29733409/neural-correlates-of-auditory-verbal-hallucinations-in-schizophrenia-and-the-therapeutic-response-to-theta-burst-transcranial-magnetic-stimulation
#1
Xingui Chen, Gong-Jun Ji, Chunyan Zhu, Xiaomeng Bai, Lu Wang, Kongliang He, Yaxiang Gao, Longxiang Tao, Fengqiong Yu, Yanghua Tian, Kai Wang
Auditory verbal hallucinations (AVHs) are a core symptom of schizophrenia, and resistant to antipsychotic medication in a substantial proportion of patients. This study aimed to investigate the neural correlates of AVHs in schizophrenia patients and its response to a modified continuous theta-burst stimulation (cTBS) by transcranial magnetic stimulation. In a cross-sectional experiment, resting-state functional magnetic resonance images were collected from 31 AVH schizophrenia patients, 26 non-AVH schizophrenia patients, and 33 sex-/age-matched healthy controls (HCs)...
May 3, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29713292/avatar-therapy-for-persistent-auditory-verbal-hallucinations-in-an-ultra-resistant-schizophrenia-patient-a-case-report
#2
Laura Dellazizzo, Stéphane Potvin, Kingsada Phraxayavong, Pierre Lalonde, Alexandre Dumais
Effective treatment strategies for schizophrenia remain very challenging and many treatment-resistant patients will suffer from persistent auditory verbal hallucinations (AVH). While clozapine is the gold-standard medication for this complex population, many will not respond to this molecule. For these ultra-resistant patients, limited options are available. Cognitive-behavioral therapy (CBT) is the most widely used psychological intervention, though it offers modest effects. With the interpersonal dimension of AVH being recognized, Avatar Therapy (AT), a novel experiential treatment enabling patients to create an avatar of their persecutor and allowing them to gain control over their symptoms, was developed and tested...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29684224/mismatch-negativity-and-cortical-thickness-in-patients-with-schizophrenia-and-bipolar-disorder
#3
Sungkean Kim, Hyeonjin Jeon, Kuk-In Jang, Yong-Wook Kim, Chang-Hwan Im, Seung-Hwan Lee
Introduction: Mismatch negativity (MMN) is a measure of automatic neurophysiological brain processes for detecting unexpected sensory stimuli. This study investigated MMN reduction in patients with schizophrenia and bipolar disorder and examined whether cortical thickness is associated with MMN, for exploratory purposes. Methods: Electroencephalograms were recorded in 38 patients with schizophrenia, 37 patients with bipolar disorder, and 32 healthy controls (HCs) performing a passive auditory oddball paradigm...
April 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29660570/the-tangled-roots-of-inner-speech-voices-and-delusions
#4
Cherise Rosen, Simon McCarthy-Jones, Kayla A Chase, Clara S Humpston, Jennifer K Melbourne, Leah Kling, Rajiv P Sharma
The role of inner speech in the experience of auditory verbal hallucinations (AVH) and delusions remains unclear. This exploratory study tested for differences in inner speech (assessed via self-report questionnaire) between 89 participants with psychosis and 37 non-clinical controls. We also tested for associations of inner speech with, i) state/trait AVH, ii) AVH-severity; iii) patients' relations with their voices, and; iv) delusion-severity. Persons with psychosis had greater levels of dialogic inner speech, other people in inner speech, and evaluative/motivational inner speech than non-clinical controls...
April 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29660081/data-driven-analysis-of-functional-connectivity-reveals-a-potential-auditory-verbal-hallucination-network
#5
Dustin Scheinost, Fuyuze Tokoglu, Michelle Hampson, Ralph Hoffman, R Todd Constable
Schizophrenia is a severe global health problem, with over half of such patients experiencing auditory verbal hallucinations (AVHs). A better understanding of the neural correlates differentiating patients experiencing AVHs from patients not experiencing AVHs and healthy controls may identify targets that lead to better treatment strategies for AVHs. Employing 2 data-driven, voxel-based measure of functional connectivity, we studied 46 patients with schizophrenia or schizoaffective disorder (28 experiencing AVHs and 18 not experiencing AVHs)...
April 5, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29593589/comorbid-diagnosis-of-psychotic-disorders-in-borderline-personality-disorder-prevalence-and-influence-on-outcome
#6
C W Slotema, Jan D Blom, Marieke B A Niemantsverdriet, Mathijs Deen, Iris E C Sommer
Background: A diagnosis of psychotic disorder is traditionally considered incompatible with borderline personality disorder (BPD), even though patients sometimes fulfill the diagnostic criteria for both disorders. How often this happens is barely known, as is the influence of comorbid psychotic disorders on the outcome of BPD. Since studies on isolated auditory verbal hallucinations in patients with BPD indicate that these perceptual symptoms have severe consequences and are associated with suicidal behavior and hospitalization, patients with comorbid psychotic disorders are unlikely to fare better...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29581420/aberrant-salience-network-functional-connectivity-in-auditory-verbal-hallucinations-a-first-episode-psychosis-sample
#7
Pavan Kumar Mallikarjun, Paris Alexandros Lalousis, Thomas Frederick Dunne, Kareen Heinze, Renate Lep Reniers, Matthew R Broome, Baldeep Farmah, Femi Oyebode, Stephen J Wood, Rachel Upthegrove
Auditory verbal hallucinations (AVH) often lead to distress and functional disability, and are frequently associated with psychotic illness. Previously both state and trait magnetic resonance imaging (MRI) studies of AVH have identified activity in brain regions involving auditory processing, language, memory and areas of default mode network (DMN) and salience network (SN). Current evidence is clouded by research mainly in participants on long-term medication, with chronic illness and by choice of seed regions made 'a priori'...
March 27, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29580740/negative-voice-content-as-a-full-mediator-of-a-relation-between-childhood-adversity-and-distress-ensuing-from-hearing-voices
#8
Cherise Rosen, Simon McCarthy-Jones, Nev Jones, Kayla A Chase, Rajiv P Sharma
A key predictor of whether or not an individual who hears voices (auditory verbal hallucinations; AVH) meets criteria for a psychiatric diagnosis is the level of negative content of the voices (e.g., threats, criticism, abuse). Yet the factors that contribute to negative voice-content are still not well understood. This study aimed to test the hypotheses that levels of childhood adversity would predict levels of negative voice-content, and that negative voice-content would partially mediate a relation between childhood adversity and voice-related distress...
March 23, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29569473/neurofeedback-based-enhancement-of-single-trial-auditory-evoked-potentials-treatment-of-auditory-verbal-hallucinations-in-schizophrenia
#9
Kathryn Rieger, Marie-Helene Rarra, Laura Diaz Hernandez, Daniela Hubl, Thomas Koenig
Auditory verbal hallucinations depend on a broad neurobiological network ranging from the auditory system to language as well as memory-related processes. As part of this, the auditory N100 event-related potential (ERP) component is attenuated in patients with schizophrenia, with stronger attenuation occurring during auditory verbal hallucinations. Changes in the N100 component assumingly reflect disturbed responsiveness of the auditory system toward external stimuli in schizophrenia. With this premise, we investigated the therapeutic utility of neurofeedback training to modulate the auditory-evoked N100 component in patients with schizophrenia and associated auditory verbal hallucinations...
March 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29559020/gene-polymorphisms-and-response-to-transcranial-direct-current-stimulation-for-auditory-verbal-hallucinations-in-schizophrenia
#10
Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
March 21, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29528896/toward-personalized-treatment-of-hallucinations
#11
Iris E Sommer, Hidde Kleijer, Kenneth Hugdahl
PURPOSE OF REVIEW: Hallucinations are common and often stressful experiences, occurring in all sensory modalities. They frequently complicate many disorders or situations, such as Parkinson's disease, schizophrenia, hearing or vision loss, intoxications and delirium. Although psychoeducation, coping techniques and psychotherapy may be broadly applicable, they do not address a specific underlying brain mechanism. Pharmacotherapy may effectively alleviate hallucinations if the corresponding mechanism is present, whereas in its absence, may only cause harmful side effects...
May 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29527474/linked-functional-network-abnormalities-during-intrinsic-and-extrinsic-activity-in-schizophrenia-as-revealed-by-a-data-fusion-approach
#12
Ryu-Ichiro Hashimoto, Takashi Itahashi, Rieko Okada, Sayaka Hasegawa, Masayuki Tani, Nobumasa Kato, Masaru Mimura
Abnormalities in functional brain networks in schizophrenia have been studied by examining intrinsic and extrinsic brain activity under various experimental paradigms. However, the identified patterns of abnormal functional connectivity (FC) vary depending on the adopted paradigms. Thus, it is unclear whether and how these patterns are inter-related. In order to assess relationships between abnormal patterns of FC during intrinsic activity and those during extrinsic activity, we adopted a data-fusion approach and applied partial least square (PLS) analyses to FC datasets from 25 patients with chronic schizophrenia and 25 age- and sex-matched normal controls...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29521298/aberrant-functional-connectivity-patterns-of-default-mode-network-may-play-a-key-role-in-the-interaction-between-auditory-verbal-hallucinations-and-insight
#13
Ri-Xing Jing, Shen Li, Xin-Jun Zhang, Jing Long, Tian-Hong Zhou, Chuan-Jun Zhuo
No abstract text is available yet for this article.
March 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29520240/a-computational-assessment-of-target-engagement-in-the-treatment-of-auditory-hallucinations-with-transcranial-direct-current-stimulation
#14
Won Hee Lee, Nigel I Kennedy, Marom Bikson, Sophia Frangou
We use auditory verbal hallucinations (AVH) to illustrate the challenges in defining and assessing target engagement in the context of transcranial direct current stimulation (tDCS) for psychiatric disorders. We defined the target network as the cluster of regions of interest (ROIs) that are consistently implicated in AVH based on the conjunction of multimodal meta-analytic neuroimaging data. These were prescribed in the New York Head (a population derived model) and head models of four single individuals. We appraised two potential measures of target engagement, tDCS-induced peak electric field strength and tDCS-modulated volume defined as the percentage of the volume of the AVH network exposed to electric field magnitude stronger than the postulated threshold for neuronal excitability...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29515172/n-acetyl-aspartate-in-the-dorsolateral-prefrontal-cortex-in-men-with-schizophrenia-and-auditory-verbal-hallucinations-a-1-5-t-magnetic-resonance-spectroscopy-study
#15
Marion Psomiades, Marine Mondino, Clara Fonteneau, Remy Bation, Frederic Haesebaert, Marie-Françoise Suaud-Chagny, Jerome Brunelin
Auditory verbal hallucinations (AVH) in patients with schizophrenia are linked to abnormalities within a large cerebral network including frontal and temporal regions. Whilst abnormalities of frontal speech production and temporal speech perception regions have been extensively studied, alterations of the dorsolateral prefrontal cortex (DLPFC), a region critically involved in the pathophysiology of schizophrenia, have rarely been studied in relation to AVH. Using 1.5 T proton magnetic resonance spectroscopy, this study examined the relationship between right and left DLPFCs N-AcetylAspartate (NAA) levels and the severity of AVH in patients with schizophrenia...
March 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29511020/reducing-distress-and-improving-social-functioning-in-daily-life-in-people-with-auditory-verbal-hallucinations-study-protocol-for-the-temstem-randomised-controlled-trial
#16
Alyssa Jongeneel, Dorien Scheffers, Nynke Tromp, Chani Nuij, Philippe Delespaul, Heleen Riper, Mark van der Gaag, David van den Berg
INTRODUCTION: Auditory verbal hallucinations (AVH) are prevalent experiences that can induce distress and impede social functioning. While most voice hearers benefit from antipsychotic medication or cognitive-behavioural therapy, additional effective interventions are needed to reduce the burden of experiencing AVH. 'Temstem' is an easily accessible and useable smartphone application that was developed by designers in close cooperation with voice hearers and experts. By using language games, Temstem aims to reduce distress and improve social functioning...
March 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29486956/virtual-reality-therapy-for-refractory-auditory-verbal-hallucinations-in-schizophrenia-a-pilot-clinical-trial
#17
Olivier Percie du Sert, Stéphane Potvin, Olivier Lipp, Laura Dellazizzo, Mélanie Laurelli, Richard Breton, Pierre Lalonde, Kingsada Phraxayavong, Kieron O'Connor, Jean-François Pelletier, Tarik Boukhalfi, Patrice Renaud, Alexandre Dumais
Schizophrenia is a chronic and severe mental illness that poses significant challenges. While many pharmacological and psychosocial interventions are available, many treatment-resistant schizophrenia patients continue to suffer from persistent psychotic symptoms, notably auditory verbal hallucinations (AVH), which are highly disabling. This unmet clinical need requires new innovative treatment options. Recently, a psychological therapy using computerized technology has shown large therapeutic effects on AVH severity by enabling patients to engage in a dialogue with a computerized representation of their voices...
February 24, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29467926/distinct-pattern-of-cerebral-blood-flow-alterations-specific-to-schizophrenics-experiencing-auditory-verbal-hallucinations-with-and-without-insight-a-pilot-study
#18
Rixing Jing, Jiangjie Huang, Deguo Jiang, Xiaodong Lin, Xiaolei Ma, Hongjun Tian, Jie Li, Chuanjun Zhuo
Schizophrenia is associated with widespread and complex cerebral blood flow (CBF) disturbance. Auditory verbal hallucinations (AVH) and insight are the core symptoms of schizophrenia. However, to the best of our knowledge, very few studies have assessed the CBF characteristics of the AVH suffered by schizophrenic patients with and without insight. Based on our previous findings, Using a 3D pseudo-continuous ASL (pcASL) technique, we investigated the differences in AVH-related CBF alterations in schizophrenia patients with and without insight...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29453445/alterations-in-interhemispheric-gamma-band-connectivity-are-related-to-the-emergence-of-auditory-verbal-hallucinations-in-healthy-subjects-during-nmda-receptor-blockade
#19
Stephanie Thiebes, Saskia Steinmann, Stjepan Curic, Nenad Polomac, Christina Andreou, Iris-Carola Eichler, Lars Eichler, Christian Zöllner, Jürgen Gallinat, Gregor Leicht, Christoph Mulert
Auditory verbal hallucinations (AVH) are a common positive symptom of schizophrenia. Excitatory-to-inhibitory (E/I) imbalance related to disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism underlying altered connectivity and AVH in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist, on glutamate-related mechanisms underlying interhemispheric gamma-band connectivity, conscious auditory perception during dichotic listening (DL), and the emergence of auditory verbal distortions and hallucinations (AVD/AVH) in healthy volunteers...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29430009/real-time-fmri-neurofeedback-to-down-regulate-superior-temporal-gyrus-activity-in-patients-with-schizophrenia-and-auditory-hallucinations-a-proof-of-concept-study
#20
Natasza D Orlov, Vincent Giampietro, Owen O'Daly, Sheut-Ling Lam, Gareth J Barker, Katya Rubia, Philip McGuire, Sukhwinder S Shergill, Paul Allen
Neurocognitive models and previous neuroimaging work posit that auditory verbal hallucinations (AVH) arise due to increased activity in speech-sensitive regions of the left posterior superior temporal gyrus (STG). Here, we examined if patients with schizophrenia (SCZ) and AVH could be trained to down-regulate STG activity using real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF). We also examined the effects of rtfMRI-NF training on functional connectivity between the STG and other speech and language regions...
February 12, 2018: Translational Psychiatry
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