keyword
https://read.qxmd.com/read/38535542/in-situ-versus-systemic-immune-response-in-the-pathogenesis-of-cutaneous-leishmaniasis
#1
JOURNAL ARTICLE
Augusto M Carvalho, Rúbia S Costa, Alexsandro Lago, Olívia Bacellar, Daniel P Beiting, Phillip Scott, Lucas P Carvalho, Edgar M Carvalho
The role of the immune response in the pathogenesis of cutaneous leishmaniasis (CL) due to Leishmania (Viannia) braziliensis is predominantly carried out via blood cells. Here, we evaluate whether cytokine production by peripheral blood mononuclear cells (PBMCs) reflects what has been documented at the lesion site. The participants included 22 CL patients diagnosed with a positive PCR. PBMCs were stimulated for 72 h with a soluble leishmania antigen (SLA). Biopsies obtained from the edge of the ulcers were incubated for the same period...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38535261/surface-treatment-of-dental-mini-sized-implants-and-screws-a-systematic-review-with-meta-analysis
#2
REVIEW
Ana Luísa Figueiredo, Raquel Travassos, Catarina Nunes, Madalena Prata Ribeiro, Mariana Santos, Flavia Iaculli, Anabela Baptista Paula, Carlos Miguel Marto, Francisco Caramelo, Inês Francisco, Francisco Vale
Miniscrews are devices that allow for absolute skeletal anchorage. However, their use has a higher failure rate (10-30%) than dental implants (10%). To overcome these flaws, chemical and/or mechanical treatment of the surface of miniscrews has been suggested. There is no consensus in the current literature about which of these methods is the gold standard; thus, our objective was to carry out a systematic review and meta-analysis of the literature on surface treatments of miniscrews. The review protocol was registered (PROSPERO CRD42023408011) and is in accordance with the PRISMA guidelines...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38530973/soft-and-hard-tissue-integration-around-percutaneous-bone-anchored-titanium-prostheses-toward-achieving-holistic-biointegration
#3
REVIEW
Sangeeta Shrivas, Harshita Samaur, Vinod Yadav, Sunil Kumar Boda
A holistic biointegration of percutaneous bone-anchored metallic prostheses with both hard and soft tissues dictates their longevity in the human body. While titanium (Ti) has nearly solved osseointegration, soft tissue integration of percutaneous metallic prostheses is a perennial problem. Unlike the firm soft tissue sealing in biological percutaneous structures (fingernails and teeth), foreign body response of the skin to titanium (Ti) leads to inflammation, epidermal downgrowth and inferior peri-implant soft tissue sealing...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38527380/synthesis-and-biological-activity-of-thiophene-bioisosteres-of-natural-styryl-lactone-goniofufurone-and-related-compounds
#4
JOURNAL ARTICLE
Mirjana Popsavin, Sanja Djokić, Ivana Kovačević, Slađana M Stanisavljević, Vesna Kojić, Marko V Rodić, Lidija Aleksić, Jelena Kesić, Bojana Srećo Zelenović, Velimir Popsavin, Dimitar S Jakimov
Ten new thiophene derivatives related to goniofufurone have been obtained by multistep synthesis starting from d-glucose. The critical step of the synthesis was the Grignard reaction of 2-thienyl magnesium bromide with a protected dialdose, yielding the C-5 epimeric thiophene derivatives 9 and 10. The mixture was oxidized to the 5-keto derivative 11, which after deprotection was converted to the corresponding keto-lactone 14. Stereoselective reduction of 14 afforded the thiophene mimic of goniofufurone 3. Esterification of 3 with cinnamic or 4-fluorocinnamic acid gave hybrids 5-7...
March 21, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38524617/characteristics-of-antenna-fabricated-using-additive-manufacturing-technology-and-the-potential-applications
#5
REVIEW
Muthanna Aziz, Amged El Hassan, Mousa Hussein, Essam Zaneldin, Ali H Al-Marzouqi, Waleed Ahmed
Antennas play a critical role in modern technology. They are used in various devices and applications, including wireless communication, broadcasting, navigation, military, and space. Overall, the importance of antennas in technology lies in their ability to transmit and receive signals, allowing communication and information transfer across various applications and devices. Three-dimensional printing technology creates antennas using multiple materials, including plastics, metals, and ceramics. Some standard 3D printing techniques used to create antennas include Fused Deposition Modeling (FDM), Stereolithography (SLA), and Selective Laser Sintering (SLS)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38516777/long-term-outcomes-following-resection-of-adenocarcinoma-arising-from-intraductal-papillary-mucinous-neoplasm-a-ipmn-versus-pancreatic-ductal-adenocarcinoma-pdac-a-propensity-score-matched-analysis
#6
JOURNAL ARTICLE
James Lucocq, James Halle-Smith, Beate Haugk, Nejo Joseph, Jake Hawkyard, Jonathan Lye, Daniel Parkinson, Steve White, Omar Mownah, Yoh Zen, Krishna Menon, Takaki Furukawa, Yosuke Inoue, Yuki Hirose, Naoki Sasahira, Anubhav Mittal, Jas Samra, Amy Sheen, Michael Feretis, Anita Balakrishnan, Carlo Ceresa, Brian Davidson, Rupaly Pande, Bobby V M Dasari, Lulu Tanno, Dimitrios Karavias, Jack Helliwell, Alistair Young, Kate Marks, Quentin Nunes, Tomas Urbonas, Michael Silva, Alex Gordon-Weeks, Jenifer Barrie, Dhanny Gomez, Stijn van Laarhoven, Hossam Nawara, Joseph Doyle, Ricky Bhogal, Ewen Harrison, Marcus Roalso, Debora Ciprani, Somaiah Aroori, Bathiya Ratnayake, Jonathan Koea, Gabriele Capurso, Ruben Bellotti, Stefan Stättner, Tareq Alsaoudi, Neil Bhardwaj, Srujan Rajesh, Fraser Jeffery, Saxon Connor, Andrew Cameron, Nigel Jamieson, Kjetil Soreide, Anthony J Gill, Keith Roberts, Sanjay Pandanaboyana
OBJECTIVE: The aim of the present study was to compare long-term post-resection oncological outcomes between A-IPMN and PDAC. SUMMARY BACKGROUND DATA: Knowledge of long term oncological outcomes (e.g recurrence and survival data) comparing between adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN) and pancreatic ductal adenocarcinoma (PDAC) is scarce. METHODS: Patients undergoing pancreatic resection (2010-2020) for A-IPMN were identified retrospectively from 18 academic pancreatic centres and compared with PDAC patients from the same time-period...
March 22, 2024: Annals of Surgery
https://read.qxmd.com/read/38509002/sustainable-vat-photopolymerization-based-3d-printing-through-dynamic-covalent-network-photopolymers
#7
JOURNAL ARTICLE
Sirawit Pruksawan, Yi Ting Chong, Wylma Zen, Terence Jun En Loh, FuKe Wang
Vat photopolymerization (VPP) based three-dimensional (3D) printing, including stereolithography (SLA) and digital light projection (DLP), is known for producing intricate, high-precision prototypes with superior mechanical properties. However, the challenge lies in the non-recyclability of covalently crosslinked thermosets used in these printing processes, limiting the sustainable utilization of printed prototypes. This review paper examines the recently explored avenue of VPP 3D-printed dynamic covalent network (DCN) polymers, which enable reversible crosslinks and allow for the reprocessing of printed prototypes, promoting sustainability...
March 20, 2024: Chemistry, An Asian Journal
https://read.qxmd.com/read/38506046/is-statistical-significance-alone-obsolete-let-s-turn-to-meaningful-interpretation-of-scientific-and-real-world-evidence-on-surgical-care
#8
JOURNAL ARTICLE
Milo A Puhan, Pierre-Alain Clavien
No abstract text is available yet for this article.
March 20, 2024: Annals of Surgery
https://read.qxmd.com/read/38506043/burn-patients-and-mental-health-a-matched-cohort-study
#9
JOURNAL ARTICLE
Gabrielle Kang-Auger, Daniel E Borsuk, Nancy Low, Aimina Ayoub, Nathalie Auger, Stéphane Buteau
OBJECTIVE: To determine the association between burns and hospitalization for mental health disorders up to three decades later. SUMMARY BACKGROUND DATA: Burns are associated with pain, disability, and scarring, but the long-term impact on mental health is unclear. METHODS: We analyzed a cohort of 23,726 burn patients aged ≥10 years who were matched to 223,626 controls from Quebec, Canada, between 1989 and 2022. The main exposure was admission for a burn...
March 20, 2024: Annals of Surgery
https://read.qxmd.com/read/38506042/trends-over-time-in-recurrence-patterns-and-survival-outcomes-after-neoadjuvant-therapy-and-surgery-for-pancreatic-cancer
#10
JOURNAL ARTICLE
Samuel H Cass, Ching-Wei D Tzeng, Laura R Prakash, Jessica Maxwell, Rebecca A Snyder, Michael P Kim, Ryan W Huey, Brandon G Smaglo, Shubham Pant, Eugene J Koay, Robert A Wolff, Jeffery E Lee, Matthew H G Katz, Naruhiko Ikoma
OBJECTIVE: We aimed to determine if advances in neoadjuvant therapy affected recurrence patterns and survival outcomes after pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Data are limited on how modern multimodality therapy affects PDAC recurrence and post-recurrence survival. METHODS: Patients who received neoadjuvant therapy followed by curative-intent pancreatectomy for PDAC during 1998-2018 were identified. Treatments, recurrence sites and timing, and survival were compared between patients who completed neoadjuvant therapy and pancreatectomy in 1998-2004, 2005-2011, and 2012-2018...
March 20, 2024: Annals of Surgery
https://read.qxmd.com/read/38506040/the-outcome-of-a-centralization-program-in-biliary-atresia-20-years-and-beyond
#11
JOURNAL ARTICLE
Mark Davenport, Erica Makin, Evelyn Gp Ong, Khalid Sharif, Michael Dawrant, Naved Alizai
OBJECTIVE: Biliary atresia (BA) is a rare disease and reported outcomes of surgical management, typically a Kasai portoenterostomy (KPE), vary considerably across the world. Centralization has been proposed to improve this. SUMMARY BACKGROUND DATA: A national centralization programme was started in Jan. 1999, involving 3 English units with co-located liver transplant facilities. As the program has now reached the 20-year point, the main aim was to update outcome statistics and identify trends...
March 20, 2024: Annals of Surgery
https://read.qxmd.com/read/38506039/intraductal-papillary-mucinous-neoplasm-surveillance-leads-to-early-diagnosis-and-better-outcomes-of-concomitant-cancer
#12
JOURNAL ARTICLE
Hiroki Oyama, Tsuyoshi Hamada, Yousuke Nakai, Mariko Tanaka, Kaoru Takagi, Rintaro Fukuda, Ryunosuke Hakuta, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Kohei Kurihara, Hiroto Nishio, Kensaku Noguchi, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Yukari Suzuki, Shinya Takaoka, Shuichi Tange, Naminatsu Takahara, Kiyoshi Hasegawa, Tetsuo Ushiku, Mitsuhiro Fujishiro
OBJECTIVE: To examine whether long-term surveillance of intraductal papillary mucinous neoplasms (IPMNs) leads to early diagnosis and better clinical outcomes of pancreatic ductal adenocarcinomas (PDACs) developing concomitantly with IPMNs. SUMMARY BACKGROUND DATA: Long-term image-based surveillance is recommended for patients with low-risk IPMNs. However, it is unknown whether the surveillance can improve surgical and survival outcomes of patients with concomitant PDACs...
March 20, 2024: Annals of Surgery
https://read.qxmd.com/read/38505886/comparison-of-malondialdehyde-levels-among-patients-with-sandblasted-acid-etched-and-anodized-surface-dental-implants-a-prospective-clinical-study
#13
JOURNAL ARTICLE
Arvina Rajasekar, Sheeja S Varghese
Inflammation that occur as a part of body's response to implant-tissue contact can result in oxidative stress. Therefore, exploring the oxidative stress around different surface treated dental implants is essential to improve the performance of implants. The purpose of this study was to detect and measure the level of malondialdehyde (MDA), oxidative stress marker among patients with sandblasted acid-etched and anodized surface dental implants. In this prospective clinical study, 78 patients who had undergone implant placement for missing single posterior tooth in mandible using sandblasted acid-etched and anodized surface dental implants during August 2019 - December 2019 were enrolled according to strict inclusion and exclusion criteria and were categorized into Group 1: SLA (n = 27), Group 2: SLActive (n = 26), Group 3: TiUnite (n = 25) based on the surface modification of the implants...
2024: Journal of Long-term Effects of Medical Implants
https://read.qxmd.com/read/38505132/plant-neighbourhood-diversity-effects-on-leaf-traits-a-meta-analysis
#14
JOURNAL ARTICLE
Juri A Felix, Philip C Stevenson, Julia Koricheva
Leaf traits often vary with plant neighbourhood composition, which in turn may mediate plant susceptibility to herbivory. However, it is unknown whether there are any common patterns of change in leaf trait expression in response to neighbourhood diversity, and whether these responses confer increased resistance or susceptibility to herbivores.We used meta-analysis to combine data from 43 studies that examined the influence of neighbourhood diversity on eight physical and chemical leaf traits that could affect herbivory...
December 2023: Functional Ecology
https://read.qxmd.com/read/38501251/dollars-and-sense-the-financial-argument-for-dedicated-post-trauma-center-care
#15
JOURNAL ARTICLE
Amy Gore, Gary Huck, Soyon Bongiovanni, Susan Labagnara, Ilona Jacniacka Soto, Peter Yonclas, David H Livingston
OBJECTIVE: The objective of the study was to demonstrate that creation of a Center for Trauma Survivorship (CTS) is not cost prohibitive but is a revenue generator for the institution. BACKGROUND: A dedicated CTS has been demonstrated to increase adherence with follow-up visits and improve overall aftercare in severely injured patients discharged from the trauma center. A potential impediment to the creation of similar centers is its assumed prohibitive cost. METHODS: This pre-and post-cohort study examines the financial impact of patients treated by the CTS...
March 19, 2024: Annals of Surgery
https://read.qxmd.com/read/38501245/characterization-of-pancreatic-fistula-after-post-pancreatectomy-acute-pancreatitis
#16
JOURNAL ARTICLE
Haoda Chen, Weishen Wang, Ningzhen Fu, Wentao Xia, Hongzhe Li, Yuchen Ji, Jingyu Zhong, Jiancheng Wang, Xiaxing Deng, Zhiwei Xu, Yuanchi Weng, Baiyong Shen
OBJECTIVE: This study aimed to investigate the clinical significance and risk factors of postoperative pancreatic fistula (POPF) after post-pancreatectomy acute pancreatitis (PPAP) in patients who underwent pancreaticoduodenectomy (PD). SUMMARY BACKGROUND DATA: PPAP has been recognized as a critical factor in the pathophysiology of POPF after PD. METHODS: A total of 817 consecutive patients who underwent elective PD between January 2020 and June 2022 were included...
March 19, 2024: Annals of Surgery
https://read.qxmd.com/read/38501239/a-retrospective-analysis-of-10-year-experience-on-branched-and-fenestrated-endovascular-aortic-arch-repair
#17
JOURNAL ARTICLE
Fiona Rohlffs, Petroula Nana, Giuseppe Panuccio, Jose I Torrealba, Nikolaos Tsilimparis, Meike Rybczynski, Christian Detter, Tilo Kölbel
OBJECTIVE: This study aimed to present the early and mid-term outcomes of fenestrated/branched thoracic endovascular aortic repair (f/bTEVAR) for aortic arch pathologies. BACKGROUND: f/bTEVAR represents a less invasive treatment option for aortic arch diseases. Previous published series showed decreased early mortality and morbidity compared to open repair. METHODS: A single-center retrospective analysis of consecutive patients, managed with f/bTEVAR (Cook Medical, Bloomington, IN, USA) between 01...
March 19, 2024: Annals of Surgery
https://read.qxmd.com/read/38501234/prognostic-alignment-a-unified-prognosis-improves-multidisciplinary-surgical-care
#18
JOURNAL ARTICLE
Orly N Farber, Elizabeth J Lilley, Richard E Leiter
No abstract text is available yet for this article.
March 19, 2024: Annals of Surgery
https://read.qxmd.com/read/38501233/would-you-rather-quantifying-tbi-survivor-perceptions-of-functional-status-via-their-surrogates
#19
JOURNAL ARTICLE
Amelia W Maiga, Madison R Cook, Mina F Nordness, Yue Gao, Shayan Rakhit, Erika L Rivera, Frank E Harrell, Mayur B Patel
OBJECTIVE: To quantify health utilities of the Glasgow Outcome Scale-Extended (GOSE) states after actual Traumatic Brain Injury (TBI). BACKGROUND: Recovery after TBI is measured using the GOSE, a validated clinical trial endpoint. A recent public survey quantified the health utilities of some GOSE states after hypothetical TBI as worse than death. However, no health utilities exist for disability after actual TBI. METHODS: This national computer-adaptive survey followed EQUATOR-CHERRIES guidelines and recruited adult TBI survivors (injury>1 y prior) via their available surrogates...
March 19, 2024: Annals of Surgery
https://read.qxmd.com/read/38496812/surface-scanned-3d-designed-customized-chinstrap-for-the-treatment-of-intraoral-dehiscence-in-polytraumatized-patient-technical-note
#20
Íñigo Aragón-Niño, José-Luis Del Castillo-Pardo-de Vera, Alessandro Gutiérrez-Venturini, Marta-María Pampín-Martínez, Clara López-Martínez, José-Luis Cebrián-Carretero
The advent of 3D surgical technology has revolutionized personalized medicine, enabling the development of tailored solutions for individual patients. This technical note presents the application of 3D technology in designing a customized chin guard using flexible 3D resin. The process involves surface scanning the lower facial region of a polytraumatized patient with a structured-light surface 3D scanner, generating a detailed point cloud. The acquired data undergoes meticulous processing within an specific professional software, including erasing unwanted portions, aligning frames, and mesh consolidation...
February 2024: Journal of Clinical and Experimental Dentistry
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