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Guerard W Byrne
The major histocompatibility complex class I and class II human leukocyte antigens (HLA) play a central role in adaptive immunity but are also the dominant polymorphic proteins targeted in allograft rejection. Sensitized patients with high levels of panel-reactive anti-HLA antibody (PRA) are at risk of early allograft injury, rejection, reduced allograft survival and often experience prolonged waiting times prior to transplantation. Xenotransplantation, using genetically modified porcine organs, offers a unique source of donor organs for these highly sensitized patients if the anti-HLA antibody, which places the allograft at risk, does not also enhance anti-pig antibody reactivity responsible for xenograft rejection...
May 2018: Xenotransplantation
Paweł Kubasiewicz-Ross, Jakub Hadzik, Marzena Dominiak
BACKGROUND: Zirconium - a bioinert metal - in comparison with titanium implants, offers a variety of potential advantages for use in the esthetic area of dentistry due to its tooth-like color. Zirconium dental implants are considered to be an alternative method of treatment to conventional titanium dental implants for patients with a thin gingival biotype. OBJECTIVES: This study was designed to study the bone tissue response to new zirconia implants with modified surfaces in comparison with commercially available titanium dental implants and commercially available zirconia implants...
June 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Nasim Sanati, Ovidiu D Iancu, Guanming Wu, James E Jacobs, Shannon K McWeeney
The heterogeneity in head and neck squamous cell carcinoma (HNSCC) has made reliable stratification extremely challenging. Behavioral risk factors such as smoking and alcohol consumption contribute to this heterogeneity. To help elucidate potential mechanisms of progression in HNSCC, we focused on elucidating patterns of gene interactions associated with tumor progression. We performed de-novo gene co-expression network inference utilizing 229 patient samples from The Cancer Genome Atlas (TCGA) previously annotated by Bornstein et al...
2018: Frontiers in Genetics
Francisco Lloret, Gerard Sapes, Teresa Rosas, Lucía Galiano, Sandra Saura-Mas, Anna Sala, Jordi Martínez-Vilalta
Background and Aims: The relationship between plant carbon economy and drought responses of co-occurring woody species can be assessed by comparing carbohydrate (C) dynamics following drought and rain periods, relating these dynamics to species' functional traits. We studied nine woody species coexisting in a continental Mediterranean shrubland that experienced severe drought effects followed by rain. Methods: We measured total non-structural carbohydrates (NSC) and soluble sugars (SS) in roots and stems during drought and after an autumn rain pulse in plants exhibiting leaf loss and in undefoliated ones...
June 8, 2018: Annals of Botany
M Ulu, T Pekbagriyanik, F Ibis, S Enhos, U K Ercan
Objectives: The aim of the present study was to compare antibiofilm efficacies of the laser in contact and noncontact application modes and cold atmospheric plasma (CAP) on Staphylococcus aureus biofilm grown on sandblasted, large grit, acid-etched (SLA) titanium discs as an in vitro model of biofilm eradication on dental implant materials. Methods: S. aureus biofilm was matured on titanium discs for 7 days then, treated with contact and noncontact Er:YAG laser and CAP...
June 2018: Nigerian Journal of Clinical Practice
Ala Hassan A Qamheya, Volkan Arısan, Zihni Mutlu, Murat Karabaglı, Merva Soluk Tekkeşin, Kamuran Kara, Ayşe Erol, Selim Ersanlı
OBJECTIVES: This study aimed to analyze and compare the topographical, chemical, and osseointegration characteristics of a sandblasted acid-etched surface (SLA group), a sandblasted thermally oxidized surface (SO group), and a surface chemically modified by hydrofluoric (HF) acid (SOF group). MATERIALS AND METHODS: Following the preparation and characterization of the relevant surfaces, 90 implants (30 for each group) were placed on the pelvic bone of six sheep...
June 7, 2018: Clinical Oral Implants Research
Daniel Holanda Barroso, Sarah De Athayde Couto Falcão, Jorgeth de Oliveira Carneiro da Motta, Laís Sevilha Dos Santos, Gustavo Henrique Soares Takano, Ciro Martins Gomes, Cecília Beatriz Fiuza Favali, Beatriz Dolabela de Lima, Raimunda Nonata Ribeiro Sampaio
Introduction: Diffuse cutaneous leishmaniasis (DCL) is a rare disease form associated with Leishmania (L.) amazonensis in South America. It represents the "anergic" pole of American Tegumentary Leishmaniasis, and the explanation for its resistance to treatment remains elusive. We aimed to study some possible immunological mechanisms involved in the poor DCL treatment response by evaluating some cell surface molecules obtained from a patient with DCL by flow cytometry. Case presentation: A 65-year-old DCL patient who initially failed to respond to the standard treatment for the disease showed vacuolated macrophages filled with amastigotes in lesion biopsy, and L ...
2018: Frontiers in Immunology
Catherine F Killan, Sally Harman, Edward C Killan
BACKGROUND: Sound localization is a valuable skill that children can develop to some extent via bilateral cochlear implants (biCIs). However, little is known regarding the change that can be expected in sound-source localization accuracy (SLA) pre- and post-biCI for children with bilateral, severe-to-profound hearing impairment who spent their early years listening via bilateral hearing aids (biHAs). This study therefore aimed to prospectively assess SLA in a group of children before, and at one year after, receiving simultaneous biCIs...
May 29, 2018: Cochlear Implants International
Seong-Bin Kim, Nam-Hoon Kim, Jae-Hong Kim, Hong-Seok Moon
STATEMENT OF PROBLEM: Rapid prototyping, including stereolithography (SLA), is a more recent technique for fabricating metal frameworks than the conventional lost-wax technique. However, investigations of the marginal discrepancies and internal spacing of cobalt-chromium (Co-Cr) metal copings fabricated using SLA are lacking. PURPOSE: The purpose of this in vitro study was to evaluate the clinical acceptability of the marginal discrepancies and internal spacing of Co-Cr metal copings fabricated using the SLA technique...
May 25, 2018: Journal of Prosthetic Dentistry
Alan Kergunteuil, Patrice Descombes, Gaetan Glauser, Loïc Pellissier, Sergio Rasmann
Predicting variation in plant functional traits related to anti-herbivore defences remains a major challenge in ecological research, considering that multiple traits have evolved in response to both abiotic and biotic conditions. Therefore, understanding variation in plant anti-herbivore defence traits requires studying their expression along steep environmental gradients, such as along elevation, where multiple biotic and abiotic factors co-vary. We expand on plant defence theory and propose a novel conceptual framework to address the sources of variations of plant resistance traits at the community level...
May 17, 2018: Oecologia
Robert C Rennert, Usman Khan, Stephen B Tatter, Melvin Field, Brian Toyota, Peter E Fecci, Kevin Judy, Alireza M Mohammadi, Patrick Landazuri, Andrew Sloan, Eric Leuthardt, Clark C Chen
BACKGROUND: Stereotactic laser ablation (SLA), also termed laser interstitial thermal therapy (LITT), is a minimally invasive procedure that is increasingly utilized in neurosurgery. We wished to examine how/if SLA is changing the landscape of treatment options for neurosurgical patients. METHODS: Patients undergoing stereotactic laser ablation were prospectively enrolled in the Laser Ablation of Abnormal Neurological Tissue (LAANTERN) registry. Data from the first 100 enrolled patients are presented here...
May 14, 2018: World Neurosurgery
Katie Tungatt, Garry Dolton, Sophie B Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A Hammond, John J Miles, David K Cole, Alain Townsend, Mick Bailey, Pierre J Rizkallah, Bryan Charleston, Elma Tchilian, Andrew K Sewell
There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current animal models used to study respiratory pathogens suffer from anatomical disparity with humans. The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume...
May 2018: PLoS Pathogens
Feridoun Parnia, Javad Yazdani, Solmaz Maleki Dizaj
The potential application of stem cell biology in human dentistry is a new and emerging field of research. The objective of the current review was to study the efficiency of mesenchymal stem cells (MSCs) in sinus lift augmentation (SLA). A literature review was performed in PubMed Central using MeSH keywords such as sinus lift, MSCs, dental implants, and augmentation. The searches involved full-text papers written in English, published in the past 10 years (2007-2017). The review included in vitro and in vivo studies on the use of MSCs in SLA...
2018: Stem Cells International
Nicholas A Chartrain, Christopher B Williams, Abby R Whittington
Vat Photopolymerization (stereolithography, SLA), an Additive Manufacturing (AM) or 3D printing technology, holds particular promise for the fabrication of tissue scaffolds for use in regenerative medicine. Unlike traditional tissue scaffold fabrication techniques, SLA is capable of fabricating designed scaffolds through the selective photopolymerization of a photopolymer resin on the micron scale. SLA offers unprecedented control over scaffold porosity and permeability, as well as pore size, shape, and interconnectivity...
May 9, 2018: Acta Biomaterialia
Alyssa Epprecht, Marco Zeltner, Goran Benic, Mutlu Özcan
This study quantified the strain development after inserting implant-borne fixed dental prosthesis (FDP) to various implant-abutment joints. Two bone-level implants (∅ = 4.1 mm, RC, SLA 10 mm, Ti, Straumann) were inserted in polyurethane models (N = 3) in the area of tooth nos 44 and 47. Four-unit veneered zirconium dioxide FDPs (n = 2) were fabricated, one of which was fixed on engaging (E; RC Variobase, ∅ = 4.5 mm, H = 3.5 mm) and the other on non-engaging (NE) abutments (RC Variobase, ∅ = 4...
February 2018: Clinical and Experimental Dental Research
Jan Strnadel, Cassiano Carromeu, Cedric Bardy, Michael Navarro, Oleksandr Platoshyn, Andreas N Glud, Silvia Marsala, Jozef Kafka, Atsushi Miyanohara, Tomohisa Kato, Takahiro Tadokoro, Michael P Hefferan, Kota Kamizato, Tetsuya Yoshizumi, Stefan Juhas, Jana Juhasova, Chak-Sum Ho, Taba Kheradmand, PeiXi Chen, Dasa Bohaciakova, Marian Hruska-Plochan, Andrew J Todd, Shawn P Driscoll, Thomas D Glenn, Samuel L Pfaff, Jiri Klima, Joseph Ciacci, Eric Curtis, Fred H Gage, Jack Bui, Kazuhiko Yamada, Alysson R Muotri, Martin Marsala
The use of autologous (or syngeneic) cells derived from induced pluripotent stem cells (iPSCs) holds great promise for future clinical use in a wide range of diseases and injuries. It is expected that cell replacement therapies using autologous cells would forego the need for immunosuppression, otherwise required in allogeneic transplantations. However, recent studies have shown the unexpected immune rejection of undifferentiated autologous mouse iPSCs after transplantation. Whether similar immunogenic properties are maintained in iPSC-derived lineage-committed cells (such as neural precursors) is relatively unknown...
May 9, 2018: Science Translational Medicine
Lin-Lin Zhu, Li-Hua Yang, Qi-Bing Xie, Geng Yin
OBJECTIVE: To explore the biochemical-immune and pathological characteristics of autoimmune hepatitis (AIH) with Sjögren's syndrome (SS) . METHODS: A total of 76 cases of AIH patients were included from January 2009 to April 2017. Among them,there were 40 cases of AIH with SS and 36 cases without SS. The liver function,immunological index,histological features,length of first diagnosis and treatment costs were compared between the two groups. RESULTS: For AIH+SS group and AIH group,the proportion of women were 97...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Xin Yuan, Yi Kang, Jun Zuo, Youneng Xie, Li Ma, Xuelei Ren, Zeyu Bian, Qiuping Wei, Kechao Zhou, Xiyang Wang, Zhiming Yu
In this paper, two kinds of titanium surfaces with novel micro/nano hierarchical structures, namely Etched (E) surface and Sandblast and etched (SE) surface, were successfully fabricated by NH4OH and H2O2 mixture. And their cellular responses of MG63 were investigated compared with Sandblast and acid-etching (SLA) surface. Scanning electron microscope (SEM), Surface profiler, X-ray photoelectron spectroscopy (XPS), and Contact angle instrument were employed to assess the surface morphologies, roughness, chemistry and wettability respectively...
2018: PloS One
Korbanjhon Brad, Yan Zhang
Background: The apigenin has important medicinal value. However, the low solubility of apigenin in water significantly reduced its application. Objective: In this study, the apigenin was extracted, and the complex of apigenin and lecithin was obtained by the solvent method and its physical and chemical properties were investigated. Materials and Methods: The apigenin was extracted from the leaves of Adinandra nitida . Afterward, its apigenin was obtained by hydrolysis and recrystallization...
April 2018: Pharmacognosy Magazine
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