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https://www.readbyqxmd.com/read/28444770/factors-associated-with-local-recurrence-in-operated-osteosarcomas-a-retrospective-evaluation-of-95-cases-from-a-tertiary-care-center-in-a-resource-challenged-environment
#1
Rishi R Poudel, Vivek Tiwari, Venkatesan S Kumar, Sameer Bakhshi, Shivanand Gamanagatti, Shah Alam Khan, Shishir Rastogi
BACKGROUND AND OBJECTIVES: Local control of disease is one of the main goals of osteosarcoma management. We conducted a retrospective evaluation of 95 operated cases of osteosarcoma over 7 years to know about the factors associated with local recurrence in resource-challenged environment of the developing world. METHODS: The factors which were evaluated and compared between local recurrence and non-local recurrence groups included demographic profile, site of tumor, whether biopsy done outside, type of surgery (limb salvage or amputation), presence of pathological fracture, vicinity of neurovascular bundle, tumor volume, histological subtype, chemotherapy induced necrosis, surgical margins, and delay in surgery...
April 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28444415/-conventional-radiological-diagnosis-of-benign-none-neoplasms
#2
A Bücker, G Schneider
BACKGROUND: Benign bone tumors are of special clinical importance because they might be confused with malignant bone tumors. OBJECTIVES: The aim of this article it to present the characteristics of benign bone tumors. The focus is orientated towards conventional x‑ray as the essential pillar for primary diagnosis. Consequently, the description of signal intensities of benign bone tumors in magnetic resonance images or less helpful clues like male-female ratios are deliberately omitted...
April 25, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28444117/exposure-opportunity-the-advantages-of-including-men-in-analyses-of-female-related-risk-factors
#3
Kirsten Rozemeijer, Saskia le Cessie, Astrid van Hylckama Vlieg, Frits R Rosendaal, Jan P Vandenbroucke, Charles Poole, Suzanne C Cannegieter
Intuitively, researchers do not include subjects who do not have the opportunity to be exposed, such as men in studies on oral contraceptives (OCs). We aimed to explore in which situations it is nevertheless beneficial to do so. We considered the effect of including men in case-control analyses of 8 different hypothetical data sets on the effect of OC use and venous thrombosis. In all scenarios, OC use was the exposure of interest, sex the factor that determined exposure opportunity, and air travel another risk factor...
April 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28443985/zika-puzzle-in-brazil-peculiar-conditions-of-viral-introduction-and-dissemination-a-review
#4
Cristina Possas, Patricia Brasil, Mauro Ca Marzochi, Amilcar Tanuri, Reinaldo M Martins, Ernesto Ta Marques, Myrna C Bonaldo, Antonio Gp Ferreira, Ricardo Lourenço-de-Oliveira, Rita Maria R Nogueira, Patricia C Sequeira, Keyla Bf Marzochi, Akira Homma
This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28440790/large-scale-modeled-contemporary-and-future-water-temperature-estimates-for-10774-midwestern-u-s-lakes
#5
Luke A Winslow, Gretchen J A Hansen, Jordan S Read, Michael Notaro
Climate change has already influenced lake temperatures globally, but understanding future change is challenging. The response of lakes to changing climate drivers is complex due to the nature of lake-atmosphere coupling, ice cover, and stratification. To better understand the diversity of lake responses to climate change and give managers insight on individual lakes, we modelled daily water temperature profiles for 10,774 lakes in Michigan, Minnesota, and Wisconsin for contemporary (1979-2015) and future (2020-2040 and 2080-2100) time periods with climate models based on the Representative Concentration Pathway 8...
April 25, 2017: Scientific Data
https://www.readbyqxmd.com/read/28440751/validation-in-daily-clinical-situations-of-diascope-%C3%A2-a-software-developed-to-help-healthcare-professionals-individualize-antidiabetic-treatment-in-type-2-diabetes
#6
Francisco Javier Ampudia-Blasco, Francisco Javier García-Soidán, Manuela Rubio Sánchez, Tra-Mi Phan
INTRODUCTION: DiaScope(®) is a software to help in individualized prescription of antidiabetic treatment in type 2 diabetes. This study assessed its value and acceptability by different professionals. MATERIAL AND METHODS: DiaScope(®) was developed based on the ADA-EASD 2012 algorithm and on the recommendation of 12 international diabetes experts using the RAND/UCLA appropriateness method. The current study was performed at a single session. In the first phase, 5 clinical scenarios were evaluated, selecting the most appropriated therapeutic option among 4 possibilities (initial test)...
March 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28439601/collapsing-glomerulopathy-the-saudi-arabian-scenario-a-study-of-31-cases-and-a-review-of-literature
#7
Sufia Husain
To compare the clinico-pathological features of collapsing glomerulopathy (CG) at a tertiary hospital in Saudi Arabia with the world literature. Methods: In a retrospective study, all biopsy-diagnosed cases of CG between 2004-2015 were identified and analyzed, at King Khalid University Hospital, King Saud University, Riyadh. The clinico-pathological findings along with prognosis were reviewed and compared with the reported literature.  Results: Thirty-one CG patients were identified, most were adult males...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28439166/end-stage-renal-disease-not-a-contraindication-for-minor-oral-surgery-protocol-for-the-management-of-oral-surgery-patients-with-esrd-on-hemodialysis
#8
Sneha Pendem, G Lakshmi Narayana, Poornima Ravi
OBJECTIVE: To describe a safe and effective protocol for the management of patients with end stage renal disease (ESRD) undergoing minor oral surgery. SUBJECTS AND METHODS: A prospective cohort study was conducted on all patients with ESRD who were referred for dental consultation. A definite protocol was designed in consultation with the nephrologist to minimize the risk of bleeding and wound healing complications during and after the minor surgical procedures...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28437843/a-bayesian-belief-network-model-assessing-the-risk-to-wastewater-workers-of-contracting-ebola-virus-disease-during-an-outbreak
#9
Joseph W Zabinski, Kelsey J Pieper, Jacqueline MacDonald Gibson
During an outbreak of Ebola virus disease (EVD), hospitals' connections to municipal wastewater systems may provide a path for patient waste bearing infectious viral particles to pass from the hospital into the wastewater treatment system, potentially posing risks to sewer and wastewater workers. To quantify these risks, we developed a Bayesian belief network model incorporating data on virus behavior and survival along with structural characteristics of hospitals and wastewater treatment systems. We applied the model to assess risks under several different scenarios of workers' exposure to wastewater for a wastewater system typical of a mid-sized U...
April 24, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28437651/population-attributable-risk-associated-with-lung-cancer-induced-by-residential-radon-in-canada-sensitivity-to-relative-risk-model-and-radon-probability-density-function-choices-in-memory-of-professor-jan-m-zielinski
#10
Mo'tassem Al-Arydah
Indoor radon has been identified as the second leading cause of lung cancer after tobacco smoking. The Population Attributable Risk (PAR) estimates the proportion of lung cancer cases associated with indoor radon exposure. Different relative risk (RR) models have been used in the literature to calculate PAR. The aim of this study is to assess how sensitive PAR is to the relative risk model and radon probability distribution functions choices. METHODS: Using Canadian observed first floor radon data collected by Health Canada during the period October 2010 to March 2011, seven common PAR radon models used for North American miners and dwelling scenarios were applied...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28437587/relationship-type-affects-the-reliability-of-dispersal-distance-estimated-using-pedigree-inferences-in-partially-sampled-populations-a-case-study-involving-invasive-american-mink-in-scotland
#11
Y Melero, M K Oliver, X Lambin
Estimating dispersal - a key parameter for population ecology and management - is notoriously difficult. The use of pedigree assignments, aided by likelihood-based softwares, has become popular to estimate dispersal rate and distance. However, the partial sampling of populations may produce false assignments. Further, it is unknown how the accuracy of assignment is affected by the genealogical relationships of individuals and is reflected by software-derived assignment probabilities. Inspired by a project managing invasive American mink (Neovison vison), we estimated individual dispersal distances using inferred pairwise relationships of culled individuals...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28437516/a-rare-case-of-misdiagnosed-silent-lung-cancer-with-solitary-metastasis-to-the-temporomandibular-joint-condyle
#12
Luca Guarda-Nardini, Edoardo Stellini, Adolfo Di Fiore, Daniele Manfredini
This article describes the case history of a 59-year-old female patient who sought advice for temporomandibular joint (TMJ) pain and sounds but who was actually diagnosed with a primary lung cancer with metastasis to the TMJ. The patient had a history of TMJ pain and deflection in jaw movement that progressively worsened over a few months and did not improve with the usual standard of care treatment provided by an orofacial pain practitioner. Magnetic resonance and computed tomography (CT) prescribed at a tertiary clinic showed an osteolytic bone mass within the right TMJ condyle...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28437460/an-aggregation-removal-model-for-the-formation-and-size-determination-of-post-synaptic-scaffold-domains
#13
Jonas Ranft, Leandro G Almeida, Pamela C Rodriguez, Antoine Triller, Vincent Hakim
The formation and stability of synapses are key questions in neuroscience. Post-synaptic domains have been classically conceived as resulting from local insertion and turnover of proteins at the synapse. However, insertion is likely to occur outside the post-synaptic domains and advances in single-molecule imaging have shown that proteins diffuse in the plane of the membrane prior to their accumulation at synapses. We quantitatively investigated this scenario using computer simulations and mathematical analysis, taking for definiteness the specific case of inhibitory synapse components, i...
April 24, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28436731/fatal-and-serious-collisions-involving-pedal-cyclists-and-trucks-in-london-between-2007-and-2011
#14
Rachel Talbot, Steve Reed, Nicola Christie, Jo Barnes, Pete Thomas
OBJECTIVE: Increased numbers of people riding pedal cycles has led to a greater focus on pedal cycle safety. The aim of this paper is to explore factors that are associated with fatal and a small number of serious injury pedal cyclist crashes involving trucks that occurred in London between 2007 and 2011. METHODS: Data were collected from police collision files for 53 crashes, 27 of which involved a truck (≥3.5 tonnes) and a pedal cycle. A systematic case review approach was used to identify the infrastructure, vehicle road user and management factors that contributed to these crashes and injuries and how these factors interacted...
February 8, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28436616/reduced-infectivity-of-waterborne-viable-but-nonculturable-helicobacter-pylori-strain-ss1-in-mice
#15
Kevin F Boehnke, Kathryn A Eaton, Clinton Fontaine, Rebecca Brewster, Jianfeng Wu, Joseph N S Eisenberg, Manuel Valdivieso, Laurence H Baker, Chuanwu Xi
BACKGROUND: Helicobacter pylori infection has been consistently associated with lack of access to clean water and proper sanitation, but no studies have demonstrated that the transmission of viable but nonculturable (VBNC) H. pylori can occur from drinking contaminated water. In this study, we used a laboratory mouse model to test whether waterborne VBNCH. pylori could cause gastric infection. MATERIALS AND METHODS: We performed five mouse experiments to assess the infectivity of VBNCH...
April 24, 2017: Helicobacter
https://www.readbyqxmd.com/read/28435826/climate-change-and-simulation-of-cardiovascular-disease-mortality-a-case-study-of-mashhad-iran
#16
Mohammad Baaghideh, Fatemeh Mayvaneh
BACKGROUND: Weather and climate play a significant role in human health. We are accustomed to affects the weather conditions. By increasing or decreasing the environment temperature or change of seasons, some diseases become prevalent or remove. This study investigated the role of temperature in cardiovascular disease mortality of city of Mashhad in the current decade and its simulation in the future decades under conditions of climate change. METHODS: Cardiovascular disease mortality data and the daily temperatures data were used during (2004-2013) period...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28434960/solitary-cysticercal-cyst-insidethe-blake-s-pouch-remnant-of-mega-cisterna-magna-with-associated-aqueductal-stenosis-the-clinical-and-management-implications
#17
Kuntal Kanti Das, Jaskaran Singh Gosal, Suyash Singh, Anant Mehrotra, Awadhesh Jaiswal, Sushila Jaiswal, Raj Kumar
BACKGROUND: Intraventricular and subarachnoid forms represent the relatively complex albeit uncommon manifestations of the central nervous system involvement by the cysticercal cysts. Cysticercal encystationinsidethe Blake's pouch remnant of mega cisterna magna remainsan extremely rare clinical scenario and to the best of our knowledge, has not been reported before. CASE REPORT: Herein, we report the case of a 12-year-old boy who presented with acute worsening and subsequent spontaneous resolution of his compensated hydrocephalus...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28434697/poor-outcomes-of-irrigation-and-debridement-in-acute-periprosthetic-joint-infection-with-antibiotic-impregnated-calcium-sulfate-beads
#18
Michael A Flierl, Brian M Culp, Kamil T Okroj, Bryan D Springer, Brett R Levine, Craig J Della Valle
BACKGROUND: One proposed strategy to increase the success of irrigation and debridement with implant retention for the treatment of acute periprosthetic joint infection (PJI) is the use of dissolvable antibiotic-impregnated calcium sulfate beads to provide a local depot of antibiotics. The purpose of this study was to evaluate the outcome of such an approach. METHODS: Thirty-two patients with acute hematogenous (18 patients; 1 bilateral) or acute postoperative (14 patients) PJIs who underwent irrigation and debridement with implant retention and addition of antibiotic-impregnated calcium sulfate beads were retrospectively reviewed...
March 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28433826/data-summarization-method-for-chronic-disease-tracking
#19
Dejan Aleksić, Petar Rajković, Dušan Vučković, Dragan Janković, Aleksandar Milenković
OBJECTIVES: Bearing in mind the rising prevalence of chronic medical conditions, the chronic disease management is one of the key features required by medical information systems used in primary healthcare. Our research group paid a particular attention to this specific area by offering a set of custom data collection forms and reports in order to improve medical professionals' daily routine. The main idea was to provide an overview of history for chronic diseases, which, as it seems, had not been properly supported in previous administrative workflows...
April 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28433450/a-retrospective-cohort-study-of-concomitant-ipsilateral-extra-capsular-and-intra-capsular-fractures-of-the-proximal-femur-are-they-casual-findings-or-an-undervalued-reality
#20
Miquel Videla-Cés, José-Miguel Sales-Pérez, Joan Girós-Torres, Rubén Sánchez-Navés, Sebastián Videla
BACKGROUND: Fractures of the proximal femur constitute a major public health problem, with an annual incidence in Spain of 7.6 cases per 1000 inhabitants over 65 years of age. Hip fractures are frequent in elderly patients, related to osteoporosis and with low energy trauma, which means that they can be considered a geriatric syndrome. Simultaneous ipsilateral extra- and intra-articular hip fractures are considered as very rare are, and generally speaking, classified as extra- or intra-capsular fractures...
April 13, 2017: Injury
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