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Molecular analysis of chemotherapy resistance

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https://www.readbyqxmd.com/read/29329575/microrna-200a-confers-chemoresistance-by-antagonizing-tp53inp1-and-yap1-in-human-breast-cancer
#1
San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di, Zhi-Ming Shao
BACKGROUND: Emerging evidence suggests molecular and phenotypic association between treatment resistance and epithelial-mesenchymal transition (EMT) in cancer. Compared with the well-defined molecular events of miR-200a in EMT, the role of miR-200a in therapy resistance remains to be elucidated. METHODS: Breast cancer cells transfected with mimic or inhibitor for miR-200a was assayed for chemoresistance in vitro. miR-200a expression was assessed by quantitative real-time PCR (qRT-PCR) in breast cancer patients treated with preoperative chemotherapy...
January 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29321966/small-interfering-rna-mediated-silencing-of-g-protein-coupled-receptor-137-inhibits-growth-of-osteosarcoma-cells
#2
Hao Li, Xiaodong Fu, Yingjian Gao, Xiaomiao Li, Yi Shen, Weili Wang
Purpose: Osteosarcoma is the most widespread primary carcinoma in bones. Osteosarcoma cells are highly metastatic and frequently develop resistance to chemotherapy making this disease harder to treat. This identifies an urgent need of novel therapeutic strategies for osteosarcoma. G-Protein-coupled receptor 137 (GPR137) is involved in several human cancers and may be a novel therapeutic target. Methods: The expression of GPR137 was assessed in one osteoblast and three human osteosarcoma cell lines via the quantitative real-time polymerase chain reaction and western blot assays...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29299405/clinical-management-of-epidermal-growth-factor-receptor-mutation-positive-non-small-cell-lung-cancer-patients-after-progression-on-previous-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-the-necessity-of-repeated-molecular-analysis
#3
REVIEW
José Luís González-Larriba, Martín Lázaro-Quintela, Manuel Cobo, Manuel Dómine, Margarita Majem, Rosario García-Campelo
One of the most important advances in the treatment of non-small cell lung cancer (NSCLC) has been the identification of molecular alterations vulnerable to targeted inhibition, such as mutations in the epidermal growth factor receptor (EGFR) gene. EGFR tyrosine kinase inhibitors (EGFR-TKIs) are targeted agents used to treat EGFR mutation-positive advanced NSCLC showing significant improvements in terms of response rate (RR) and progression-free survival (PFS) compared to conventional chemotherapy. However, all patients eventually develop resistance to first-line EGFR-TKIs...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29296238/the-implication-from-ras-raf-erk-signaling-pathway-increased-activation-in-epirubicin-treated-triple-negative-breast-cancer
#4
Jianbo Huang, Qingqing Luo, Yun Xiao, Hongyuan Li, Lingquan Kong, Guosheng Ren
Background: Triple negative breast cancer (TNBC) is not sensitive to RAS/RAF/ERK signaling pathway (ERK pathway) targeting therapy, due to the absence of excessive activation of ERK pathway. However, the kinase cascades might be activated after chemotherapy in TNBC. Here we aimed to predict whether ERK pathway targeting therapy could be used as an adjuvant therapy in TNBC. Methods: Within online GEO datasets (GSE43816 and GSE54326), gene set enrichment analysis (GSEA) was performed to detect molecular changes in epirubicin treated TNBC samples and cells, ERK pathway components and regulation genes changes were included...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29229751/suv420h2-is-an-epigenetic-regulator-of-epithelial-mesenchymal-states-in-pancreatic-cancer
#5
Manuel Viotti, Catherine Wilson, Mark McCleland, Hartmut Koeppen, Benjamin Haley, Suchit Jhunjhunwala, Christiaan Klijn, Zora Modrusan, David Arnott, Marie Classon, Jean-Philippe Stephan, Ira Mellman
Epithelial-to-mesenchymal transition is implicated in metastasis, where carcinoma cells lose sessile epithelial traits and acquire mesenchymal migratory potential. The mesenchymal state is also associated with cancer stem cells and resistance to chemotherapy. It might therefore be therapeutically beneficial to promote epithelial identity in cancer. Because large-scale cell identity shifts are often orchestrated on an epigenetic level, we screened for candidate epigenetic factors and identified the histone methyltransferase SUV420H2 (KMT5C) as favoring the mesenchymal identity in pancreatic cancer cell lines...
December 11, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29228556/riemerella-anatipestifer-m949_0459-gene-is-responsible-for-the-bacterial-resistance-to-tigecycline
#6
Tao Li, Min Shan, Jing He, Xiaolan Wang, Shaohui Wang, Mingxing Tian, Jingjing Qi, Tingrong Luo, Yonghong Shi, Chan Ding, Shengqing Yu
Based on its important role in last-line therapeutics against multidrug-resistant bacteria, tigecycline has been increasingly important in treating infections. However, mounting reports on tigecycline-resistant bacterial strains isolated from different sources are of concern, and molecular mechanisms regarding tigecycline resistance are poorly understood. Riemerella anatipestifer is a Gram-negative, non-motile, non-spore-forming, rod-shaped bacterium, which causes fibrinous pericarditis, perihepatitis, and meningitis in infected ducks...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224787/global-research-output-in-antimicrobial-resistance-among-uropathogens-a-bibliometric-analysis-2002-2016
#7
Waleed M Sweileh, Samah W Al-Jabi, Sa 'ed H Zyoud, Ansam F Sawalha, Adham S Abu-Taha
BACKGROUND: Antimicrobial resistance (AMR) among uropathogens contributes to treatment failure. Research in AMR among uropathogens is important to establish treatment. The aim of this study was to assess global research trends in AMR among uropathogens. METHODS: Sciverse Scopus was used to retrieve relevant documents for the period from 2002 to 2016. Only journal articles were included in the analysis. Analysis of author keywords was carried out using VOSviewer...
December 7, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29197426/phenotypic-and-genotypic-monitoring-of-schistosoma-mansoni-in-tanzanian-schoolchildren-five-years-into-a-preventative-chemotherapy-national-control-programme
#8
Charlotte M Gower, Florian Gehre, Sara R Marques, Poppy H L Lamberton, Nicholas J Lwambo, Joanne P Webster
BACKGROUND: Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Chemotherapy (PC). Large-scale PC programmes exert prolonged selection pressures on parasites with the potential for, direct and/or indirect, emergence of drug resistance. Molecular methods can help monitor genetic changes of schistosome populations over time and in response to drug treatment, as well as estimate adult worm burdens through parentage analysis...
December 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29196965/metabolomic-prediction-of-treatment-outcome-in-pancreatic-ductal-adenocarcinoma-patients-receiving-gemcitabine
#9
Lee Cheng Phua, Shixu Goh, David Wai Meng Tai, Wei Qiang Leow, Syed Muhammad Fahmy Alkaff, Chung Yip Chan, Juinn Huar Kam, Tony Kiat Hon Lim, Eric Chun Yong Chan
PURPOSE: Resistance to gemcitabine remains a key challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), necessitating the constant search for effective strategies for a priori prediction of clinical outcome. While the existing studies focused on aberration of drug disposition genes and proteins as molecular predictors of gemcitabine treatment outcomes, the metabolic aberration associated with chemoresistance in clinical PDAC has been neglected. This exploratory study investigated the potential role of tissue metabolomics in characterizing the clinical treatment outcome of gemcitabine therapy...
December 1, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29190892/lncrna-h19-is-a-major-mediator-of-doxorubicin-chemoresistance-in-breast-cancer-cells-through-a-cullin4a-mdr1-pathway
#10
Qiong-Ni Zhu, Guo Wang, Ying Guo, Yan Peng, Rui Zhang, Jun-Li Deng, Zhi-Xing Li, Yuan-Shan Zhu
Development of chemoresistance is a persistent problem during cancer treatment. Long non-coding RNAs (LncRNAs) are currently emerging as an integral functional component of the human genome and as critical regulators of cancer development and progression. In the present study, we investigated the role and molecular mechanism of H19 lncRNA in chemoresistance development by using doxorubicin (Dox) resistance in breast cancer cells as a model system. H19 lncRNA expression was significantly increased in anthracycline-treated and Dox-resistant MCF-7 breast cancer cells...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29187901/mutational-landscape-of-cfdna-identifies-distinct-molecular-features-associated-with-therapeutic-response-to-first-line-platinum-based-doublet-chemotherapy-in-patients-with-advanced-nsclc
#11
Tao Jiang, Xuefei Li, Jianfei Wang, Chunxia Su, Wenbo Han, Chao Zhao, Fengying Wu, Guanghui Gao, Wei Li, Xiaoxia Chen, Jiayu Li, Fei Zhou, Jing Zhao, Weijing Cai, Henghui Zhang, Bo Du, Jun Zhang, Shengxiang Ren, Caicun Zhou, Hui Yu, Fred R Hirsch
Rationale To investigate whether the mutational landscape of circulating cell-free DNA (cfDNA) could predict and dynamically monitor the response to first-line platinum-based chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). Methods Eligible patients were included and blood samples were collected from a phase III trial. Both cfDNA fragments and fragmented genomic DNA were extracted for enrichment in a 1.15M size panel covering exon regions of 1,086 genes. Molecular mutational burden (MMB) was calculated to investigate the relationship between molecular features of cfDNA and response to chemotherapy...
2017: Theranostics
https://www.readbyqxmd.com/read/29175872/notch-pathway-inhibition-targets-chemoresistant-insulinoma-cancer-stem-cells
#12
Ylenia Capodanno, Floryne O Buishand, Lisa Y Pang, Jolle Kirpensteijn, Jan A Mol, David J Argyle
Insulinomas (INS) are the most common neuroendocrine pancreatic tumours in humans and dogs. The long-term prognosis for malignant INS is still poor due to a low success rate of the current treatment modalities, particularly chemotherapy. A better understanding of the molecular processes underlying the development and progression of INS is required to develop novel targeted therapies. Cancer stem cells (CSCs) are thought to be critical for the engraftment and chemoresistance of many tumours, including INS. This study was aimed to characterise and target INS CSCs in order to develop novel targeted therapies...
November 24, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29174652/introduction-novel-hybrid-combinations-containing-synthetic-or-antibiotic-drugs-with-plant-derived-phenolic-or-terpenoid-compounds
#13
Hildebert Wagner, Thomas Efferth
BACKGROUND: There is a paradigm shift in chemotherapy from mono-drug therapy towards multidrug combination regimens. Natural products from medicinal plants may play an important role for the design of novel combination therapy protocols. HYPOTHESIS: We introduce the novel term "hybrid combination" for the therapeutic combination of chemically defined plant-derived constituents (e.g. phenolic or terpenoid compounds with synthetic or antibiotic drugs to increase pharmacological activity and simultaneously toxic side effects...
November 2, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29163677/trim37-promotes-tumor-cell-proliferation-and-drug-resistance-in-pediatric-osteosarcoma
#14
Yanling Tao, Meiyun Xin, Huanchen Cheng, Zongxuan Huang, Tiantian Hu, Teng Zhang, Jianlong Wang
Osteosarcoma (OS) is among the most frequently occurring bone tumors, particularly in children. Clinical treatment of OS is limited due to several factors including resistance to chemotherapy drugs and metastasis, and the underlying molecular mechanisms remain unclear. In the present study, tripartite motif containing 37 (TRIM37) expression levels were upregulated in tumor samples and associated with the development of drug resistance in OS. Furthermore, chemotherapy drug treatment (doxorubicin, cisplatin and methotrexate) induced TRIM37 expression in OS cells in vitro...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29153103/comprehensive-analysis-of-gene-expression-profiles-reveals-novel-candidates-of-chemotherapy-resistant-factors-in-canine-lymphoma
#15
Miyu Suenaga, Hirotaka Tomiyasu, Manabu Watanabe, Kotogo Ogawa, Tomoki Motegi, Yuko Goto-Koshino, Koichi Ohno, Sumio Sugano, Katherine A Skorupski, Hajime Tsujimoto
The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29149426/relationship-between-lat1-expression-and-resistance-to-chemotherapy-in-pancreatic-ductal-adenocarcinoma
#16
Bolag Altan, Kyoichi Kaira, Akira Watanabe, Norio Kubo, Pinjie Bao, Gantumur Dolgormaa, Erkhem-Ochir Bilguun, Kenichiro Araki, Yoshikatsu Kanai, Takehiko Yokobori, Tetsunari Oyama, Masahiko Nishiyama, Hiroyuki Kuwano, Ken Shirabe
PURPOSE: L-type amino acid transporter 1 (LAT1) is linked to tumor cell proliferation, angiogenesis, and survival in various human cancers. Although the expression of LAT1 was identified as a significant prognostic predictor after surgery in patients with pancreatic ductal adenocarcinoma (PDAC), little is known about the clinical significance of LAT1 as a chemotherapeutic resistance factor in PDAC. METHODS: A total of 110 patients with surgically resected PDAC were retrospectively reviewed as the training set...
November 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29125238/lncrna-uca1-promotes-proliferation-and-cisplatin-resistance-of-oral-squamous-cell-carcinoma-by-sunppressing-mir-184-expression
#17
Zheng Fang, Junfang Zhao, Weihong Xie, Qiang Sun, Haibin Wang, Bin Qiao
Chemotherapy resistance has become the main obstacle for the effective treatment of human cancers. Long non-coding RNA urothelial cancer associated 1 (UCA1) is generally regarded as an oncogene in some cancers. However, the function and molecular mechanism of UCA1 implicated in cisplatin (CDDP) chemoresistance of oral squamous cell carcinoma (OSCC) is still not fully established. UCA1 expression in tumor tissues and cells was tested by qRT-PCR. MTT, flow cytometry and caspase-3 activity analysis were explored to evaluate the CDDP sensitivity in OSCC cells...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29116143/risk-factors-and-molecular-features-of-sequence-type-st-131-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-community-onset-bacteremia
#18
Hyunsoo Kim, Young Ah Kim, Yoon Soo Park, Min Hyuk Choi, Gyeong In Lee, Kyungwon Lee
Due to the spread of a single CTX-M-type extended-spectrum β-lactamase (ESBL) clone of sequence type (ST) 131, community-onset bacteremia caused by ESBL-producing Escherichia coli has increased dramatically. We evaluated the risk factors and molecular features of ESBL-producing E. coli ST131 clones isolated from Korean patients with community-onset bacteremia. We collected a total of 124 ESBL-producing E. coli isolates from blood in patients with community-onset bacteremia over a 2 year-period. Among 124 patients, the number of community-associated bacteremia cases was 57 (46%)...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100359/the-conjugated-antimetabolite-5-fdu-ecyd-and-its-cellular-and-molecular-effects-on-platinum-sensitive-vs-resistant-ovarian-cancer-cells-in-vitro
#19
Sarah Schott, Pauline Wimberger, Barbara Klink, Konrad Grützmann, Julian Puppe, Ulrike Sophie Wauer, Daniel Martin Klotz, Evelin Schröck, Jan Dominik Kuhlmann
Background: Resistance to platinum-based chemotherapy is a clinical challenge in the treatment of ovarian cancer (OC) and limits survival. Therefore, innovative drugs against platinum-resistance are urgently needed. Our therapeutic concept is based on the conjugation of two chemotherapeutic compounds to a monotherapeutic pro-drug, which is taken up by cancer cells and cleaved into active cytostatic metabolites. We explore the activity of the duplex-prodrug 5-FdU-ECyd, covalently linking 2'-deoxy-5-fluorouridine (5-FdU) and 3'-C-ethynylcytidine (ECyd), on platinum-resistant OC cells...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048400/cd10-aldh-cells-are-the-sole-cisplatin-resistant-component-of-a-novel-ovarian-cancer-stem-cell-hierarchy
#20
Brendan Ffrench, Claudia Gasch, Karsten Hokamp, Cathy Spillane, Gordon Blackshields, Thamir Mahmoud Mahgoub, Mark Bates, Louise Kehoe, Aoibhinn Mooney, Ronan Doyle, Brendan Doyle, Dearbhaile O'Donnell, Noreen Gleeson, Bryan T Hennessy, Britta Stordal, Ciaran O'Riain, Helen Lambkin, Sharon O'Toole, John J O'Leary, Michael F Gallagher
It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CSC hierarchies and chemoresistance in an ovarian cancer model. Using a single cell-based approach to CSC discovery and validation, we report a novel, four-component CSC hierarchy based around the markers cluster of differentiation 10 (CD10) and aldehyde dehydrogenase (ALDH)...
October 19, 2017: Cell Death & Disease
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