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Charles Cole, Ashley Byrne, Anna E Beaudin, E Camilla Forsberg, Christopher Vollmers
RNA-sequencing (RNA-seq) is a powerful technique to investigate and quantify entire transcriptomes. Recent advances in the field have made it possible to explore the transcriptomes of single cells. However, most widely used RNA-seq protocols fail to provide crucial information regarding transcription start sites. Here we present a protocol, Tn5Prime, that takes advantage of the Tn5 transposase-based Smart-seq2 protocol to create RNA-seq libraries that capture the 5' end of transcripts. The Tn5Prime method dramatically streamlines the 5' capture process and is both cost effective and reliable...
March 14, 2018: Nucleic Acids Research
Dayna A Johnson, Jana A Hirsch, Kari A Moore, Susan Redline, Ana V Diez Roux
Although dense neighborhood built environments support increased physical activity and lower obesity, these features may also disturb sleep. Therefore, we sought to understand the association between the built environment and objectively measured sleep. From 2010 to 2013, we analyzed data from examination 5 of the Multi-Ethnic Study of Atherosclerosis, a diverse population from 6 US cities. We fit multilevel models that assessed the association between the built environment (Street Smart Walk Score, social engagement destinations, street intersections, and population density) and sleep duration or efficiency from 1-week wrist actigraphy in 1,889 individuals...
March 14, 2018: American Journal of Epidemiology
Ivan Yu Chernyshov, Philip V Toukach
Motivation: Glycans and glycoconjugates are usually recorded in dedicated databases in residue-based notations. Only a few of them can be converted into chemical (atom-based) formats highly demanded in conformational and biochemical studies. In this work, we present a tool for translation from a residue-based glycan notation to SMILES. Results: The REStLESS algorithm for translation from the CSDB Linear notation to SMILES was developed. REStLESS stands for ResiduEs as Smiles and LinkagEs as SmartS, where SMARTS reaction expressions are used to merge pre-encoded residues into a molecule...
March 14, 2018: Bioinformatics
Shuming Qiu, Guoai Xu, Haseeb Ahmad, Yanhui Guo
The Session Initiation Protocol (SIP) is an extensive and esteemed communication protocol employed to regulate signaling as well as for controlling multimedia communication sessions. Recently, Kumari et al. proposed an improved smart card based authentication scheme for SIP based on Farash's scheme. Farash claimed that his protocol is resistant against various known attacks. But, we observe some accountable flaws in Farash's protocol. We point out that Farash's protocol is prone to key-compromise impersonation attack and is unable to provide pre-verification in the smart card, efficient password change and perfect forward secrecy...
2018: PloS One
Anung Riapanitra, Yusuke Asakura, Wenbin Cao, Yasuto Noda, Shu Yin
Fluorine-doped VOsub>2</sub>(M) nanoparticles have been successfully synthesized using the hydrothermal method at a supercritical temperature of 490°C. The pristine VO<sub>2</sub>(M) has the critical phase transformation temperature of 64°C. The morphology and homogeneity of the monoclinic structure VO<sub>2</sub>(M) were adopted by the fluorine-doped system. The crystallinity and particle size were reduced the bigger the concentration of fluorine doping...
March 16, 2018: Nanotechnology
Srabanti Ghosh, Laurence Ramos, Hynd Remita
Materials are the key roadblocks for the commercialization of energy conversion devices in fuel cells and solar cells. Significant research has focused on tuning the intrinsic properties of materials at the nanometer scale. The soft template mediated controlled fabrication of advanced nanostructured materials is attracting considerable interest due to the promising applications of these materials in catalysis and electrocatalysis. Swollen hexagonal lyotropic liquid crystals (SLCs) consist of oil-swollen surfactant-stabilized 1D, 2D or 3D nanometric assemblies regularly arranged in an aqueous solvent...
March 16, 2018: Nanoscale
Zhili Wan, Yingen Sun, Lulu Ma, Feibai Zhou, Jian Guo, Song-Qing Hu, Xiao-Quan Yang
Nanofibrils from self-assembly of the naturally occurring saponin glycyrrhizic acid (GA) can be used to create an oil-in-water emulsion foam with long-term stability. Through a homogenization and aeration followed by a rapid cooling, stable emulsion foams can be produced from the mixtures of sunflower oil and saponin nanofibrils. At high temperature, the GA fibrils form a multilayer assembly at the interface, creating an interfacial fibrillar network to stabilize the oil droplets and air bubbles generated during homogenization...
March 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
M Waseem Akram, Muhammad Fakhar-E-Alam, M Atif, Alvina Rafique Butt, Ali Asghar, Yasir Jamil, K S Alimgeer, Zhiming M Wang
MgO is an attractive choice for carcinogenic cell destruction in photodynamic therapy, as confirmed by manifold analysis. The prime focus of the presented research is to investigate the toxicity caused by morphologically different MgO nanostructures obtained by annealing at various annealing temperatures. Smart (stimuli-responsive) MgO nanomaterials are a very promising class of nanomaterials, and their properties can be controlled by altering their size, morphology, or other relevant characteristics. The samples investigated here were grown by the co-precipitation technique...
March 15, 2018: Scientific Reports
Amy Mulick, Jane Walker, Stephen Puntis, Katy Burke, Stefan Symeonides, Charlie Gourley, Marta Wanat, Chris Frost, Michael Sharpe
BACKGROUND: Comorbid major depression has been associated with worse survival in patients with cancer. However, we do not know if treating depression improves survival. In the SMaRT Oncology-2 (good prognosis cancers) and SMaRT Oncology-3 (lung cancer, a poor prognosis cancer) trials, we found that a depression treatment programme, Depression Care for People with Cancer (DCPC), was effective in reducing comorbid major depression. In this analysis, we aimed to identify whether DCPC also had an effect on survival...
March 12, 2018: Lancet Psychiatry
Joo-Yong Hahn, Young Bin Song, Ju-Hyeon Oh, Deok-Kyu Cho, Jin Bae Lee, Joon-Hyung Doh, Sang-Hyun Kim, Jin-Ok Jeong, Jang-Ho Bae, Byung-Ok Kim, Jang Hyun Cho, Il-Woo Suh, Doo-Il Kim, Hoon-Ki Park, Jong-Seon Park, Woong Gil Choi, Wang Soo Lee, Jihoon Kim, Ki Hong Choi, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon
BACKGROUND: Current guidelines recommend dual antiplatelet therapy (DAPT) of aspirin plus a P2Y12 inhibitor for at least 12 months after implantation of drug-eluting stents (DES) in patients with acute coronary syndrome. However, available data about the optimal duration of DAPT in patients with acute coronary syndrome undergoing percutaneous coronary intervention are scant. We aimed to investigate whether a 6-month duration of DAPT would be non-inferior to the conventional 12-month or longer duration of DAPT in this population...
March 9, 2018: Lancet
Yang Jin, Xiaolong An, Mingqiao Ge
In this study, we fabricated a heat-stimulated luminous fiber (HSLF) by wet spinning. The HSLF consists of Sr₂ZnSi₂O₇: Eu2+ , Dy3+ (SZSO), Y₂O₂S: Eu3+ , Mg2+ , Ti4+ (YOS), and heat-sensitive green TF-G pigment (HSGP). SZSO and YOS serve as a source of luminescence to yield a long afterglow system. HSGP is a heat-stimulating agent which develops the link between luminescence and temperature for HSLF. The luminescence of the HSLF is dull below 30 °C, but vivid above 30 °C. The luminescence of HSLFs can be stimulated by low heat (human body temperature)...
March 15, 2018: Materials
Yuwei Hao, Hongliang Liu, Guannan Li, Haijun Cui, Lei Jiang, Shutao Wang
To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface - poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays - by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing efficiencies of cancer cell capture and release. These enhanced efficiencies of cancer cell capture and release probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units...
March 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Ajay Kumar, Sumit Sharma, Rohit Mehra, Saurabh Narang, Rosaline Mishra
Background The inhalation doses resulting from the exposure to radon, thoron, and their progeny are important quantities in estimating the radiation risk for epidemiological studies as the average global annual effective dose due to radon and its progeny is 1.3 mSv as compared to that of 2.4 mSv due to all other natural sources of ionizing radiation. Objectives The annual inhalation dose has been assessed with an aim of investigating the health risk to the inhabitants of the studied region. Methods Time integrated deposition based222 Rn/220 Rn sensors have been used to measure concentrations in 146 dwellings of Udhampur district, Jammu and Kashmir...
March 15, 2018: International Journal of Occupational and Environmental Health
Haeree Park, Yeongkyu Choi, M T Jeena, Eungjin Ahn, Yuri Choi, Myeong-Gyun Kang, Chae Gyu Lee, Tae-Hyuk Kwon, Hyun-Woo Rhee, Ja-Hyoung Ryu, Byeong-Su Kim
Owing to the unique advantages of combining the characteristics of hydrogels and nanoparticles, nanogels are actively investigated as a promising platform for advanced biomedical applications. In this work, a self-cross-linked hyperbranched polyglycerol nanogel is synthesized using the thiol-disulfide exchange reaction based on a novel disulfide-containing polymer. A series of structural analyses confirm the tunable size and cross-linking density depending on the type of polymer (homo- or copolymer) and the amount of reducing agent, dithiothreitol, used in the preparation of the nanogels...
March 15, 2018: Macromolecular Bioscience
Qunfeng Cheng, Jingsong Peng
Nacre-inspired nanocomposites with excellent mechanical properties have achieved remarkable success in the past decades. The high performance of nacre-inspired nanocomposites lays down the basis for the further application of smart devices. Recently, some smart nanocomposites inspired by nacre have demonstrated well mechanical properties as well as effective and stable stimuli-responsive functions. In this concept, we summarize the recent development of smart nacre-inspired nanocomposites including 1D fibers, 2D films and 3D bulk nanocomposites in response to temperature, moisture, light, strain, etc...
March 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
F Guégan, W Lamine, H Chermette, C Morell
In a recent article Polanco-Ramirez et al. proposed new definitions of local chemical potential and local hardness starting from the first derivative of the energy with respect to the number of electrons and a smart use of the chain rule. In this comment we show that this derivation appears naturally in the Taylor expansion of the energy, showing that the construction of Polanco-Ramirez et al. is not artificially built.
March 15, 2018: Physical Chemistry Chemical Physics: PCCP
Frank L Schwartz, Cynthia R Marling, Razvan C Bunescu
Development of truly useful wearable physiologic monitoring devices for use in diabetes management is still in its infancy. From wearable activity monitors such as fitness trackers and smart watches to contact lenses measuring glucose levels in tears, we are just at the threshold of their coming use in medicine. Ultimately, such devices could help to improve the performance of sense-and-respond insulin pumps, illuminate the impact of physical activity on blood glucose levels, and improve patient safety. This is a summary of our experience attempting to use such devices to enhance continuous glucose monitoring-augmented insulin pump therapy...
March 1, 2018: Journal of Diabetes Science and Technology
Xiaoye Yang, Xiaoqun Shi, Jianbo Ji, Guangxi Zhai
The development of imaging-guided smart drug delivery systems for combinational photodynamic/chemotherapy of the tumor has become highly demanded in oncology. Herein, redox-responsive theranostic polymeric nanoparticles (NPs) were fabricated innovatively using low molecular weight heparin (LWMH) as the backbone. Chlorin e6 (Ce6) and alpha-tocopherol succinate (TOS) were conjugated to LMWH via cystamine as the redox-sensitive linker, forming amphiphilic Ce6-LMWH-TOS (CHT) polymer, which could self-assemble into NPs in water and encapsulate paclitaxel (PTX) inside the inner core (PTX/CHT NPs)...
November 2018: Drug Delivery
Jinzhao Song, Vikram Pandian, Michael G Mauk, Haim H Bau, Sara Cherry, Laurence C Tisi, Changchun Liu
Rapid and quantitative molecular diagnostics in the field, at home, and at remote clinics is essential for evidence-based disease management, control, and prevention. Conventional molecular diagnostics requires extensive sample preparation, complex instruments, and skilled personnel, restricting its use to centralized laboratories. To overcome these limitations, we designed a simple, inexpensive, hand-held, smartphone-based mobile detection platform, dubbed "smart-connected cup" (SCC), for rapid, connected and quantitative molecular diagnostics...
March 15, 2018: Analytical Chemistry
Nash Ak Witten, Joseph Humphry
The Lana'i Community Health Center (LCHC) like other health care organizations, is striving to implement technology-enabled care (TEC) in the clinical setting. TEC includes such technological innovations as patient portals, mobile phone applications, wearable health sensors, and telehealth. This study examines the utilization of communication technology by members of the Lana'i community and LCHC staff and board members in the home and in their daily lives and evaluates the community's electronic health literacy...
March 2018: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
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