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https://www.readbyqxmd.com/read/27890326/the-effect-of-metabolic-comorbidities-and-commonly-used-drugs-on-the-prognosis-of-patients-with-ovarian-cancer
#1
Daniel Bar, Ofer Lavie, Nili Stein, Ido Feferkorn, Ayelet Shai
BACKGROUND: Diabetes mellitus is associated with an increased risk of recurrence in patients with ovarian cancer. Retrospective studies suggested that the use of statins, metformin and beta blockers is associated with improved prognosis in these patients. Patients with diabetes often suffer from hypertension and are usually treated concomitantly by several classes of drugs. Our aim was to assess the independent contribution of diabetes mellitus and hypertension and of the use of aspirin, statins, metformin and beta blockers on the risk of ovarian cancer recurrence and mortality...
October 14, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27646613/increased-indoleamine-2-3-dioxygenase-activity-in-type-2-diabetic-nephropathy
#2
Yue Zhang, Yizhe Ruan, Ping Zhang, Li Wang
AIM: The study aimed to test the hypothesis that indoleamine 2,3-dioxygenase (IDO) plays a pathogenic role in type 2 diabetic nephropathy (DN). METHODS: One hundred individuals were recruited in our study from January 2012 to December 2013, including group A (control group, 24 healthy adults), group B (20 patients with latent glomerulonephritis), group C (32 type 2 DN patients, estimated glomerular filtration rate (eGFR) >30ml/min per 1.73m(2)), group D (24 maintenance hemodialysis, MHD patients)...
August 28, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27643646/metformin-increases-e-cadherin-in-tumors-of-diabetic-patients-with-endometrial-cancer-and-suppresses-epithelial-mesenchymal-transition-in-endometrial-cancer-cell-lines
#3
Ido Laskov, Paul Abou-Nader, Oreekha Amin, Charles-Andre Philip, Marie-Claude Beauchamp, Amber Yasmeen, Walter H Gotlieb
PURPOSE: Epithelial-mesenchymal transition (EMT) is a critical process for cancer metastasis and recurrence. Metformin, an effective oral antidiabetic drug, has been associated with decreased cancer risk and mortality. In this pilot study, we started to evaluate the effect of metformin on EMT in vivo and in vitro in endometrial cancer (EC). METHODS: Endometrial cancer cell lines and freshly isolated EC tumor specimens were used to assess EMT after metformin treatment...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27534430/knockdown-of-gsk3%C3%AE-increases-basal-autophagy-and-ampk-signalling-in-nutrient-laden-human-aortic-endothelial-cells
#4
Karen A Weikel, José M Cacicedo, Neil B Ruderman, Yasuo Ido
High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by decreasing basal autophagy and AMP-activated protein kinase (AMPK) activity, although the mechanisms by which this occurs are not clear. Decreased function of the lysosome, an organelle required for autophagy and AMPK, have been associated with hyperactivity of glycogen synthase kinase 3β (GSK3β). To determine whether GSK3β affects nutrient-induced changes in autophagy and AMPK activity, we used a primary human aortic endothelial cell (HAEC) model of type 2 diabetes that we had previously characterized with impaired AMPK activity and autophagy [Weikel et al...
October 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27529430/exaggerated-increases-in-microglia-proliferation-brain-inflammatory-response-and-sickness-behaviour-upon-lipopolysaccharide-stimulation-in-non-obese-diabetic-mice
#5
Barry McGuiness, Sinead M Gibney, Wouter Beumer, Marjan A Versnel, Inge Sillaber, Andrew Harkin, Hemmo A Drexhage
: The non-obese diabetic (NOD) mouse, an established model for autoimmune diabetes, shows an exaggerated reaction of pancreas macrophages to inflammatory stimuli. NOD mice also display anxiety when immune-stimulated. Chronic mild brain inflammation and a pro-inflammatory microglial activation is critical in psychiatric behaviour. OBJECTIVE: To explore brain/microglial activation and behaviour in NOD mice at steady state and after systemic lipopolysaccharide (LPS) injection...
2016: Neuroimmunomodulation
https://www.readbyqxmd.com/read/27452433/telomere-homeostasis-in-placentas-from-pregnancies-with-uncontrolled-diabetes
#6
Tal Biron-Shental, Meital Liberman, Michal Elbaz, Ido Laish, Reuven Sharony, Aliza Amiel
OBJECTIVE: Diabetes during pregnancy causes an intrauterine environment that influences lifetime sickness of the mother and the fetus. There is a correlation between diabetes and telomere shortening; however, very little is known about telomere homeostasis in the placenta. We aimed to study the telomerase complex in placentas and in cord blood leukocytes from patients with poorly controlled diabetes. METHODS: Biopsies from 16 third-trimester placentas and cord blood samples from pregnancies complicated with uncontrolled diabetes and from 16 gestational age-matched controls from uncomplicated pregnancies were examined...
August 2016: Placenta
https://www.readbyqxmd.com/read/27424698/screening-for-kidney-disease-in-an-oil-producing-community-in-nigeria-a-pilot-study
#7
Umezurike H Okafor, S Ahmed, O Arigbodi, S Idogun, E I Unuigbe
Petroleum products have been associated with acute and chronic kidney disease. Nigeria is a major oil producing and exporting country. The aim of this study was to screen for kidney disease in an oil producing community in Nigeria. This was a cross-sectional study carried out in Ido, Asari-Toru Local Government Area of Rivers State. All subjects were resident in the town and those aged 18 years and above were eligible. Spot urine samples were collected for dipstick urinalysis, and venous blood was collected for estimation of serum electrolyte, urea, creatinine, and lipid profile...
July 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27329801/proposed-mechanisms-for-oligonucleotide-imt504-induced-diabetes-reversion-in-a-mouse-model-of-immunodependent-diabetes
#8
María S Bianchi, Stefanía Bianchi, Andrés Hernado-Insúa, Leandro M Martinez, Néstor Lago, Carlos Libertun, Norma A Chasseing, Alejandro D Montaner, Victoria A Lux-Lantos
Type 1 diabetes (T1D) originates from autoimmune β-cell destruction. IMT504 is an immunomodulatory oligonucleotide that increases mesenchymal stem cell cloning capacity and reverts toxic diabetes in rats. Here, we evaluated long-term (20 doses) and short-term (2-6 doses) effects of IMT504 (20 mg·kg(-1)·day(-1) sc) in an immunodependent diabetes model: multiple low-dose streptozotocin-injected BALB/c mice (40 mg·kg(-1)·day(-1) ip for 5 consecutive days). We determined blood glucose, glucose tolerance, serum insulin, islet morphology, islet infiltration, serum cytokines, progenitor cell markers, immunomodulatory proteins, proliferation, apoptosis, and islet gene expression...
August 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27181414/diabetic-complications-within-the-context-of-aging-nicotinamide-adenine-dinucleotide-redox-insulin-c-peptide-sirtuin-1-liver-kinase-b1-adenosine-monophosphate-activated-protein-kinase-positive-feedback-and-forkhead-box-o3
#9
REVIEW
Yasuo Ido
Recent research in nutritional control of aging suggests that cytosolic increases in the reduced form of nicotinamide adenine dinucleotide and decreasing nicotinamide adenine dinucleotide metabolism plays a central role in controlling the longevity gene products sirtuin 1 (SIRT1), adenosine monophosphate-activated protein kinase (AMPK) and forkhead box O3 (FOXO3). High nutrition conditions, such as the diabetic milieu, increase the ratio of reduced to oxidized forms of cytosolic nicotinamide adenine dinucleotide through cascades including the polyol pathway...
July 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27178798/overexpression-of-ppc-and-lysc-to-improve-the-production-of-4-hydroxyisoleucine-and-its-precursor-l-isoleucine-in-recombinant-corynebacterium-glutamicum-ssp-lactofermentum
#10
Feng Shi, Huimin Fang, Tengfei Niu, Zhengke Lu
4-hydroxyisoleucine (4-HIL) exhibits unique insulinotropic and insulin-sensitizing activities and is an attractive candidate for the treatment of type II and type I diabetes. In our previous study, l-isoleucine dioxygenase gene (ido) was cloned and overexpressed in an l-isoleucine-producing strain, Corynebacterium glutamicum ssp. lactofermentum SN01, and 4-HIL was produced from the endogenous l-isoleucine (Ile). In this study, ppc and lysC were co-expressed with ido to increase the supply of Ile, the direct precursor of 4-HIL, and to further improve the 4-HIL yield...
June 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27052494/the-mutual-effect-of-pregestational-body-mass-index-maternal-hyperglycemia-and-gestational-weight-gain-on-adverse-pregnancy-outcomes
#11
Ariel Zilberlicht, Ido Feferkorn, Grace Younes, Amit Damti, Ron Auslender, Shlomit Riskin-Mashiah
OBJECTIVE: To investigate the mutual effect of obesity, gestational diabetes (GDM) and gestational weight gain (GWG) on adverse pregnancy outcomes. METHODS: Charts of patients who delivered in our hospital between June 2001 and June 2006 singleton, live births  >24 weeks gestation were reviewed. Univariate and multivariate logistic regression were used to assess pregnancy outcomes defined as large for gestational age (LGA), primary cesarean section (PCS) and a composite outcome of LGA and/or PCS...
2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26879762/regulating-the-expression-of-cd80-cd86-on-dendritic-cells-to-induce-immune-tolerance-after-xeno-islet-transplantation
#12
Nengwen Ke, Anping Su, Wei Huang, Peter Szatmary, Zhaoda Zhang
BACKGROUND: Antigen present cells (APCs) have been demonstrated to play dual roles in immune tolerance. Recently, compelling evidence indicates that APCs that express CD80, but not CD86 can protect allograft. We investigated whether modulation of CD80 in dendritic cells (DCs) offer protection for xeno-islets. METHODS: In vitro, isolated mature murine DCs received untransfection, transfection with CD86 siRNA or negative control siRNA. The DCs were used in mixed lymphocyte reaction in which rat islets and murine splenocytes were further added...
July 2016: Immunobiology
https://www.readbyqxmd.com/read/26779542/oral-probiotic-vsl-3-prevents-autoimmune-diabetes-by-modulating-microbiota-and-promoting-indoleamine-2-3-dioxygenase-enriched-tolerogenic-intestinal-environment
#13
Jayashree Dolpady, Chiara Sorini, Caterina Di Pietro, Ilaria Cosorich, Roberto Ferrarese, Diego Saita, Massimo Clementi, Filippo Canducci, Marika Falcone
The gut microbiota modulates the autoimmune pathogenesis of type 1 diabetes (T1D) via mechanisms that remain largely unknown. The inflammasome components are innate immune sensors that are highly influenced by the gut environment and play pivotal roles in maintaining intestinal immune homeostasis. In this study we show that modifications of the gut microbiota induced by oral treatment with Lactobacillaceae-enriched probiotic VSL#3, alone or in combination with retinoic acid (RA), protect NOD mice from T1D by affecting inflammasome at the intestinal level...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26765526/fibroblast-cell-based-therapy-for-experimental-autoimmune-diabetes
#14
Reza B Jalili, Yun Zhang, Azadeh Hosseini-Tabatabaei, Ruhangiz T Kilani, Mohsen Khosravi Maharlooei, Yunyuan Li, Sanam Salimi Elizei, Garth L Warnock, Aziz Ghahary
Type 1 diabetes (T1D) results from autoimmune destruction of insulin producing β cells of the pancreatic islets. Curbing autoimmunity at the initiation of T1D can result in recovery of residual β cells and consequently remission of diabetes. Here we report a cell-based therapy for autoimmune diabetes in non-obese diabetic (NOD) mice using dermal fibroblasts. This was achieved by a single injection of fibroblasts, expressing the immunoregulatory molecule indoleamine 2,3 dioxygenase (IDO), into peritoneal cavity of NOD mice shortly after the onset of overt hyperglycemia...
2016: PloS One
https://www.readbyqxmd.com/read/26581230/reduced-worries-of-hypoglycaemia-high-satisfaction-and-increased-perceived-ease-of-use-after-experiencing-four-nights-of-md-logic-artificial-pancreas-at-home-dream4
#15
Claudia Ziegler, Alon Liberman, Revital Nimri, Ido Muller, Simona Klemenčič, Nataša Bratina, Sarah Bläsig, Kerstin Remus, Moshe Phillip, Tadej Battelino, Olga Kordonouri, Thomas Danne, Karin Lange
AIMS: This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS: In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10-54 years, 54% male, HbA1c 7.89 ± 0.69% [62.72 ± 7.51 mmol/mol], diabetes duration 11.6 ± 8.4 yrs) answered standardized questionnaires (HFS, adapted TAM, and AP satisfaction) before and after using the AP...
2015: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26523229/elevated-anthranilic-acid-plasma-concentrations-in-type-1-but-not-type-2-diabetes-mellitus
#16
Gregory Oxenkrug, Marieke van der Hart, Paul Summergrad
Experimental data suggested involvement of tryptophan (Trp) - kynurenine (Kyn) pathway (TKP) in mechanisms of autoimmune, type 1 (T1D), and metabolic, type 2 (T2D), diabetes. However, clinical evaluations of TKP metabolites were limited to T2D. We assessed Trp, Kyn and TKP metabolites: anthranilic (AA), kynurenic (KYNA) and xanthurenic (XA) acids, in plasma samples of fifteen T1D, thirty T2D patients and twenty eight non-diabetic subjects by HPLC-mass spectrometry. Trp concentrations were higher in T1D than in T2D and controls while Kyn concentrations were not changed suggesting down-regulation of indoleamine-2,3-dioxygenase (IDO), a rate-limiting enzyme of TKP, in T1D...
2015: Integrative Molecular Medicine
https://www.readbyqxmd.com/read/26201002/is-the-association-of-serum-sodium-with-mortality-in-patients-with-type-2-diabetes-explained-by-copeptin-or-nt-probnp-zodiac-46
#17
Ineke J Riphagen, Susan J J Logtenberg, Klaas H Groenier, Kornelis J J van Hateren, Gijs W D Landman, Joachim Struck, Gerjan Navis, Jenny E Kootstra-Ros, Ido P Kema, Henk J G Bilo, Nanne Kleefstra, Stephan J L Bakker
BACKGROUND AND AIMS: Hyponatremia has been associated with an increased mortality risk in the general population. Diabetes is a condition predisposing for elevated levels of arginine vasopressin (AVP) and heart failure, both common causes of hyponatremia. These factors, however, are also associated with an increased mortality risk. We aimed to investigate whether serum sodium is associated with cardiovascular and all-cause mortality in type 2 diabetes and whether these associations could be explained by copeptin, a surrogate for AVP, or NT-proBNP, a marker for heart failure...
September 2015: Atherosclerosis
https://www.readbyqxmd.com/read/26047877/-vascular-age-and-cardiovascular-risk-in-patients-suffering-from-stroke
#18
E Goeh Akue, Y M Afassinou, B J F Ido, M Pio, S Baragou, S Pessinaba, V Kumako, M Belo
AIMS: To determine the vascular age of patients suffering from stroke and their cardiovascular risk at 10 years and to compare their vascular age to their real age. MATERIAL AND METHODS: It was about a descriptive and retrospective study carried up from 1st January 2012 to 31st December 2013 at the neurologic clinic of the University teaching hospital Sylvanus Olympio of Lome from patients' files with a confirmed diagnostic of stroke according to the clinical examination and the scanner data...
June 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26021394/screening-for-risk-factors-of-chronic-kidney-disease-in-a-community-in-niger-delta-nigeria
#19
Umezurike Hughes Okafor, S Ahmed, E I Unuigbe
BACKGROUND: Chronic kidney disease (CKD) is associated with many traditional and nontraditional risk factors. Screening for these risk factors has been associated with appropriate interventions and preventive measures in the management of CKD. The aims and objective of this study are to screen for risk factors of CKD in a Niger Delta community in Nigeria. SUBJECTS AND METHODS: This was a cross-sectional study. The study location was Ido, a Niger Delta community in Rivers State...
July 2015: Annals of African Medicine
https://www.readbyqxmd.com/read/25959254/impaired-toll-like-receptor-signalling-in-peripheral-b-cells-from-newly-diagnosed-type-2-diabetic-subjects
#20
Haridoss Madhumitha, Viswanathan Mohan, Nathella P Kumar, Rajendra Pradeepa, Subash Babu, Vivekanandhan Aravindhan
Toll-like receptors (TLRs) under diabetic conditions trigger inflammation and impair immunity. In the present study, we looked at the expression of TLRs (2 and 4) and their adaptors in Normal Glucose Tolerant (NGT), Newly Diagnosed Type-2 Diabetic (NDD) and Known Type-2 Diabetic (KDM) subjects. We also estimated TLR induced cytokine secretion, cellular activation and apoptosis. Surface expression of TLR2 and 4 was significantly reduced in the B cells of the NDD subjects and was associated with decreased cellular activation and cytokine secretion (TNF-α and IL-6)...
December 2015: Cytokine
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