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https://www.readbyqxmd.com/read/29165496/fluorescence-quenching-based-signal-amplification-on-immunochromatography-test-strips-for-dual-mode-sensing-of-two-biomarkers-of-breast-cancer
#1
Bo Zhang, Wenjuan Ma, Fuxin Li, Weichen Gao, Qian Zhao, Weipan Peng, Jiafang Piao, Xiaoli Wu, Hanjie Wang, Xiaoqun Gong, Jin Chang
Recently, immunochromatography test strips (ICTS) have been fully developed for point-of-care testing (POCT). However, the intrinsic limitations including non-quantitative detection of colloidal gold ICTS and low sensitivity of fluorescence ICTS (FICTS) significantly restrict their further application in clinical diagnosis. Taking advantages of rapid colorimetric qualitative detection and fluorescence quantitation, we designed a kind of sensitive and dual-mode magnetic FICTS (mFICTS) based on PLGA@Fe3O4 super-paramagnetic nanosphere (SPMN) probes quenching multiplex fluorescer on the test line through sandwich immunoreactions...
November 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/29165356/fast-detection-of-a-brca2-large-genomic-duplication-by-next-generation-sequencing-as-a-single-procedure-a-case-report
#2
Marcella Nunziato, Flavio Starnone, Barbara Lombardo, Matilde Pensabene, Caterina Condello, Francesco Verdesca, Chiara Carlomagno, Sabino De Placido, Lucio Pastore, Francesco Salvatore, Valeria D'Argenio
The aim of this study was to verify the reliability of a next generation sequencing (NGS)-based method as a strategy to detect all possible BRCA mutations, including large genomic rearrangements. Genomic DNA was obtained from a peripheral blood sample provided by a patient from Southern Italy with early onset breast cancer and a family history of diverse cancers. BRCA molecular analysis was performed by NGS, and sequence data were analyzed using two software packages. Comparative genomic hybridization (CGH) array was used as confirmatory method...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29165068/identifying-candidates-for-breast-cancer-using-interactions-of-chemicals-and-proteins
#3
Jing Lu, Kangle Shang, Yi Bi
Breast cancer is one of the major cause of cancer death in women worldwide. Therefore, it is urgent to discovery novel drugs or design effective treatments for this disease. However, the research and development of drugs by using only experimental methods is always time-consuming and expensive. With the development of computer science, some advanced computational methods can make full use of known knowledge to design candidate drugs, thereby reducing the cost and time of experimental testing. In this study, a computational method was proposed to identify novel candidates for breast cancer...
November 20, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29164972/molecular-subtyping-of-breast-cancer-improves-identification-of-both-high-and-low-risk-patients
#4
Maria Rossing, Olga Østrup, Wiktor W Majewski, Savvas Kinalis, Maj-Britt Jensen, Ann Knoop, Niels Kroman, Maj-Lis Talman, Thomas V O Hansen, Bent Ejlertsen, Finn C Nielsen
BACKGROUND: Transcriptome analysis enables classification of breast tumors into molecular subtypes that correlate with prognosis and effect of therapy. We evaluated the clinical benefits of molecular subtyping compared to our current diagnostic practice. MATERIALS AND METHODS: Molecular subtyping was performed on a consecutive and unselected series of 524 tumors from women with primary breast cancer (n = 508). Tumors were classified by the 256 gene expression signature (CIT) and compared to conventional immunohistochemistry (IHC) procedures...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164969/accuracy-of-self-reported-family-history-of-cancer-mutation-status-and-tumor-characteristics-in-patients-with-early-onset-breast-cancer
#5
Annelie Augustinsson, Carolina Ellberg, Ulf Kristoffersson, Åke Borg, Håkan Olsson
BACKGROUND: The main objectives of this study were to evaluate the concordance between self-reported and registry-reported information regarding family history of breast cancer (BC), ovarian cancer (OvC) and other types of cancer in first-degree relatives of patients with early onset BC, and to determine the frequency of mutation carriers and non-mutation carriers. The secondary objective was to describe tumor characteristics for each mutation group. MATERIAL AND METHODS: Between 1993 and 2013, 231 women who were ≤35 years old when diagnosed with BC were registered at the Oncogenetic Clinic at Skåne University Hospital in Lund, Sweden...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164968/characterization-of-basal-like-subtype-in-a-danish-consecutive-primary-breast-cancer-cohort
#6
Savvas Kinalis, Finn Cilius Nielsen, Maj-Lis Talman, Bent Ejlertsen, Maria Rossing
BACKGROUND: Transcriptome analysis enables classification of breast tumors into molecular subtypes. BRCA1/2 predisposed patients are more likely to suffer from a basal-like subtype and this group of patients displays a more distinct phenotype and genotype. Hence, in-depth characterization of this separate entity is needed. MATERIAL AND METHODS: Molecular subtyping was performed on a consecutive and unselected series of 1560 tumors from patients with primary breast cancer...
November 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29164938/an-examination-of-sociocultural-factors-associated-with-mammography-screening-among-latina-immigrants
#7
John S Luque, Yelena N Tarasenko, Debbie Chatman Bryant, Caroline Davila, Grace Soulen
INTRODUCTION: The study hypothesized that sociocultural factors would be associated with breast cancer screening within the past 2 years among Latina immigrant women. METHOD: This study employed a survey design and included 82 Latina immigrant female participants 40 to 64 years of age for the analysis. Two multivariable binary logistic regression models were estimated, one for the sociocultural deterrents and the other for the symptomatic deterrents from the Cultural Cancer Screening Scale...
September 2017: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29164922/health-care-access-utilization-and-cancer-screening-among-low-income-latina-women
#8
Cynthia M Mojica, Bertha Flores, Norma S Ketchum, Yuanyuan Liang
INTRODUCTION: Cancer screening reduces mortality rates for breast, cervical, and colon cancer. Yet cancer screening rates for Latina women are lower than for non-Latino Whites, and below Healthy People 2020 goals. Additionally, Latinos face many health care access barriers. This study examined health care access and utilization in relation to cancer screening among low-income Latina women recruited from a high-risk area and enrolled in a navigation-plus-education intervention. METHODS: Latina women considered rarely or never screened for breast, cervical, or colorectal cancer were recruited from community-based organizations and events (N = 691)...
January 1, 2017: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/29162419/leveraging-twitter-to-maximize-the-radiology-meeting-experience
#9
Vivek Kalia, Daniel A Ortiz, Amy K Patel, Andrew K Moriarity, Cheri L Canon, Richard Duszak
Over recent years, social media engagement has proliferated among physicians, health care systems, scientific journals, professional societies, and patients. In radiology, Twitter (Twitter Inc, San Francisco, California) has rapidly become the preferred social media engagement tool and is now an essential activity at many large radiology society meetings. Twitter offers a versatile, albeit simple, platform for anyone interested in engaging with others, regardless of title, stature, or geography. In radiology and other medical specialties, year-after-year increases in Twitter engagement before, during, and after professional society meetings continue with widespread positive feedback...
November 18, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29162161/international-szent-gy%C3%A3-rgyi-prize-for-progress-in-cancer-research-basic-and-translational-research-recognition-mary-claire-king-received-the-2016-prize-for-her-pioneering-research-that-demonstrated-the-first-evidence-of-genetic-predisposition-to-breast-cancer
#10
EDITORIAL
Hali Hartmann, Jie Zhao, Sujuan Ba
The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer research globally with the ultimate goal to cure cancer. The coveted Szent-Györgyi Prize annually honors a scientist whose seminal discovery or body of work has resulted in, or led toward, notable contributions to cancer prevention, diagnosis, or treatment; and the discovery has had a high direct impact of saving people's lives...
November 21, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29162038/a-qualitative-study-on-singaporean-women-s-views-towards-breast-cancer-screening-and-single-nucleotide-polymorphisms-snps-gene-testing-to-guide-personalised-screening-strategies
#11
Xin Yi Wong, Kok Joon Chong, Janine A van Til, Hwee Lin Wee
BACKGROUND: Breast cancer is the top cancer by incidence and mortality in Singaporean women. Mammography is by far its best screening tool, but current recommended age and interval may not yield the most benefit. Recent studies have demonstrated the potential of single nucleotide polymorphisms (SNPs) to improve discriminatory accuracy of breast cancer risk assessment models. This study was conducted to understand Singaporean women's views towards breast cancer screening and SNPs gene testing to guide personalised screening strategies...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161653/psychosocial-issues-of-a-population-approach-to-high-genetic-risk-identification-behavioural-emotional-and-informed-choice-issues
#12
David P French, Anthony Howell, D Gareth Evans
To allow women at high genetic risk of breast cancer to benefit from prevention or early prevention strategies, a screening programme is required to identify them. The present review considers the likelihood of key outcomes that would arise from such a programme, in relation to behavioural, emotional and informed choice outcomes. The likelihood of outcomes in each category is considered in relation to the limited direct evidence and relevant indirect evidence, given the dearth of studies that have directly studied the effects of communication of personal genetic risk of breast cancer...
November 18, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29159881/characterization-of-photon-counting-multi-slit-breast-tomosynthesis
#13
Karl Berggren, Björn Cederström, Mats Lundqvist, Erik Fredenberg
PURPOSE: It has been shown that breast tomosynthesis may improve sensitivity and specificity compared to 2D mammography, resulting in increased detection-rate of cancers or lowered call-back rates. The purpose of this study is to characterize a spectral photon-counting multi-slit breast tomosynthesis system that is able to do single-scan spectral imaging with multiple collimated x-ray beams. The system differs in many aspects compared to conventional tomosynthesis using energy-integrating flat-panel detectors...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159815/effectiveness-of-interventions-for-breast-cancer-screening-in-african-american-women-a-meta-analysis
#14
Valire Carr Copeland, Yoo Jung Kim, Shaun M Eack
OBJECTIVE: The purpose of this study was to report the results of a meta-analysis conducted on the effects of clinical trials in breast cancer screening for African American women between 1997 and 2017. DATA SOURCES: Articles published in English and in the United States, between January 1997 and March 2017, were eligible for inclusion if they (1) conducted psychosocial, behavioral, or educational interventions designed to increase screening mammography rates in predominantly African American women of all ages; (2) utilized a randomized, controlled trial (RCT) design; and (3) reported quantitative screening rates following the intervention...
November 21, 2017: Health Services Research
https://www.readbyqxmd.com/read/29159811/a-deep-learning-method-for-classifying-mammographic-breast-density-categories
#15
Aly A Mohamed, Wendie A Berg, Hong Peng, Yahong Luo, Rachel C Jankowitz, Shandong Wu
PURPOSE: Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29159778/risk-of-leptomeningeal-carcinomatosis-in-patients-with-brain-metastases-treated-with-stereotactic-radiosurgery
#16
Rosaline Ma, Morgan Levy, Bin Gui, Shou-En Lu, Venkat Narra, Sharad Goyal, Shabbar Danish, Simon Hanft, Atif J Khan, Jyoti Malhotra, Sabin Motwani, Salma K Jabbour
There is limited available literature examining factors that predispose patients to the development of LMC after stereotactic radiosurgery (SRS) for brain metastases. We sought to evaluate risk factors that may predispose patients to LMC after SRS treatment in this case-control study of patients with brain metastases who underwent single-fraction SRS between 2011 and 2016. Demographic and clinical information were collected retrospectively for 19 LMC cases and 30 controls out of 413 screened patients with brain metastases...
November 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29159661/safety-of-clomiphene-citrate-a-literature-review
#17
REVIEW
Serkan Yilmaz, Neslihan Yilmaz Sezer, İlknur Münevver Gönenç, Sibel Erkal İlhan, Ebru Yilmaz
Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not? In the light of this question, this review aimed to highlight all researches and insights into the association between the use of CC and risk of genotoxicity, cytotoxicity, embryotoxicity, teratogenicity and risk of different cancer types. We conducted a MEDLINE/PubMed, Scopus, Web of Science, Google Scholar search. After a careful screening process of all authors, 32 of these articles were considered as appropriate, and reviewed...
November 20, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29158039/association-between-the-american-board-of-internal-medicine-s-general-internist-s-maintenance-of-certification-requirement-and-mammography-screening-for-medicare-beneficiaries
#18
Bradley M Gray, Jonathan L Vandergrift, Rebecca S Lipner
BACKGROUND: Breast cancer is a leading cause of death in the United States. Continuing medical education programs such as the American Board of Internal Medicine's Maintenance of Certification (MOC) program can increase early detection of cancers by educating physicians about the benefits of screening. Did the imposition of American Board of Internal Medicine's MOC requirement affect guideline-compliant mammography screening? METHOD: To address this question, we took advantage of a natural experiment that occurred when one group of general internists was required to complete MOC by 2001 because they initially certified in 1991 (MOC required) and another group was grandfathered out of this requirement because they initially certified in 1989 (MOC grandfathers)...
November 17, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29157874/air-travel-and-postoperative-lymphedema-a-systematic-review
#19
REVIEW
Michael Co, Judy Ng, Ava Kwong
Lymphedema is not uncommon after axillary dissection for breast cancer. Improved survival of patients with breast cancer from advances in adjuvant therapy has resulted in increased awareness of the quality of life for long-term survivors. Air travel has been postulated as 1 of the risk factors of lymphedema exacerbation. In the present systematic review, we sought to critically evaluate the current data on this topic. The present study was registered in the Research Registry. A systematic review of lymphedema and air travel was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol...
October 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29156009/discovering-cancer-vulnerabilities-using-high-throughput-micro-rna-screening
#20
Iva Nikolic, Benjamin Elsworth, Eoin Dodson, Sunny Z Wu, Cathryn M Gould, Pieter Mestdagh, Glenn M Marshall, Lisa G Horvath, Kaylene J Simpson, Alexander Swarbrick
Micro-RNAs (miRNAs) are potent regulators of gene expression and cellular phenotype. Each miRNA has the potential to target hundreds of transcripts within the cell thus controlling fundamental cellular processes such as survival and proliferation. Here, we exploit this important feature of miRNA networks to discover vulnerabilities in cancer phenotype, and map miRNA-target relationships across different cancer types. More specifically, we report the results of a functional genomics screen of 1280 miRNA mimics and inhibitors in eight cancer cell lines, and its presentation in a sophisticated interactive data portal...
November 16, 2017: Nucleic Acids Research
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