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Capsular contracture silicone implant

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https://www.readbyqxmd.com/read/29692660/the-satisfaction-of-patients-with-breast-cancer-undergone-immediate-reconstruction-with-implant-and-the-effect-of-radiotherapy
#1
Ayse Y Altinok, Nuran Bese, Halil Kara, Sukru Yazar, Cihan Unal
Aim of the study: Postmastectomy reconstructive surgery for cosmetic satisfaction of patients is rapidly increasing. Postoperative complications such as infection, capsular contracture, implant loss are more common in patients who receive adjuvant radiotherapy (RT) than those who do not. Satisfaction levels in patients is still a controversial issue. Therefore, we wanted to investigate our patient population for the effects of RT and planned a study evaluating the satisfaction rates of our patients who received implants...
2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29663703/cytological-features-of-breast-peri-implant-papillary-synovial-metaplasia
#2
José A Jiménez-Heffernan, Carmen Bárcena, Patricia Muñoz-Hernández
Synovial metaplasia is a peculiar form of metaplasia seen in the inner lining of the fibrous capsule that surrounds breast implants. Since the description of breast-implant associated anaplastic large cell lymphoma it is increasingly common to receive periprosthetic breast fluid collections for pathologic analysis. We describe a case of breast-implant papillary synovial metaplasia that showed remarkable cytologic findings. A review of the medical literature revealed one previous cytologic description. The patient, A 53-year-old woman underwent surgery because of capsular contracture of textured, silicone breast implants...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29649133/current-approaches-including-novel-nano-microtechniques-to-reduce-silicone-implant-induced-contracture-with-adverse-immune-responses
#3
REVIEW
Shin Hyuk Kang, Chanutchamon Sutthiwanjampa, Chan Young Heo, Woo Seob Kim, Soo-Hong Lee, Hansoo Park
Capsular contracture, which is the pathologic development of fibrous capsules around implants, is a major complication of reconstructive and aesthetic breast surgeries. Capsular contracture can cause implant failure with breast hardening, deformity, and severe pain. The exact mechanisms underlying this complication remain unclear. In addition, anaplastic large cell lymphoma is now widely recognized as a very rare disease associated with breast implants. Foreign body reactions are an inevitable common denominator of capsular contracture...
April 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29595714/ten-year-core-study-data-for-sientra-s-food-and-drug-administration-approved-round-and-shaped-breast-implants-with-cohesive-silicone-gel
#4
W Grant Stevens, M Bradley Calobrace, Kaveh Alizadeh, Kamakshi R Zeidler, Jennifer L Harrington, Rosalyn C d'Incelli
BACKGROUND: In March 2012, the United States Food and Drug Administration approved Sientra's application for premarket approval of its portfolio of round and shaped silicone gel breast implants based on data from the largest silicone gel breast implant study to date. This article presents the results of Sientra's Core Study at the conclusion of 10 years. METHODS: The Sientra Core Study was a 10-year, open-label, prospective, multicenter clinical study designed to assess the safety and effectiveness of Sientra's breast implants in augmentation and reconstruction...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29564486/evaluation-of-safe-systemic-immunosuppression-created-with-dexamethasone-in-prevention-of-capsular-contracture-a-glance-to-distinct-perspectives-with-toll-like-receptors
#5
Ozlem Colak, Kadri Ozer, Adile Dikmen, Hilal Ozakinci, Ozay Ozkaya
PURPOSE: The toll-like receptors (TLRs) stand at the interface of innate immune activation. We hypothesize to decrease the response of innate immunity activated by TLR4 by a safe, short-term, systemic immunosuppression. METHODS: Two silicone block implants were placed into two dorsal subcutaneous pockets in 32 rats that were subdivided into four groups: The two study groups were the IV DEX group (single intravenous injection of dexamethasone 1 h before surgery) and the IV DEX + IP DEX group (in addition to a single intravenous injection of dexamethasone 1 h before surgery, intraperitoneal dexamethasone was administered for 10 days after surgery), and the two control groups were the untreated control group and the saline-treated control group...
March 21, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29523044/a-murine-model-of-radiation-induced-capsule-tissue-reactions-around-smooth-silicone-implants
#6
Jae Bong Kim, Hyeon Jun Jeon, Jeong Woo Lee, Kang Young Choi, Ho Yun Chung, Byung Chae Cho, Shin-Hyung Park, Min Hee Park, Jae-Sung Bae, Jung Dug Yang
As the availability of breast reconstruction using implants is becoming widespread and many implant recipients undergo radiation therapy, there is an increasing interest in understanding the potential complications associated with capsule-tissue interactions in response to irradiation. Accordingly, our medical institution designed an animal experiment to investigate the effects of irradiation on capsular contracture. A total of 40 mice (C57BL6) were divided into four groups according to whether or not they received irradiation and the time from implantation to irradiation...
March 9, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29487671/a-10-year-prospective-study-of-implant-based-breast-augmentation-and-reconstruction
#7
Robert El-Haddad, Béatrice Lafarge-Claoue, Charles Garabedian, Sylvain Staub
Objective: Observational studies are essential for ensuring patient safety, decreasing complications, and developing better surgical techniques and implants. The primary objective of this study is to demonstrate the safety and efficacy of Sebbin breast implants in both augmentation and reconstruction cohorts. Methods: This prospective, multicenter, observational 10-year study conducted in France included 205 patients (385 implants) who underwent breast augmentation (n = 166) or reconstruction (n = 39) with Sebbin round silicone gel implants...
2018: Eplasty
https://www.readbyqxmd.com/read/29452341/betadine-and-breast-implants
#8
Mark L Jewell, William P Adams
In the fourth quarter of 2017, the US FDA reviewed and approved a request by one of the breast implant manufacturers for a change in the Directions for Use (DFU) that removed warnings regarding the use of Betadine (povidone-iodine [PI] 10% solution, 1% available iodine [Purdue Frederick Company, Stamford, CT], also available in generic formulations [Aplicare, Inc., Meriden, CT]). Previously, in 2000, there were concerns by the FDA that PI would degrade the silicone elastomer shell. This change in the DFU represents an important advance that will benefit patients through the permitted use of PI to reduce the risk of bacterial contamination of implant surfaces...
February 14, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29420643/immunophenotypic-characterization-of-human-t-cells-after-in-vitro-exposure-to-different-silicone-breast-implant-surfaces
#9
Giuseppe Cappellano, Christian Ploner, Susanne Lobenwein, Sieghart Sopper, Paul Hoertnagl, Christina Mayerl, Nikolaus Wick, Gerhard Pierer, Georg Wick, Dolores Wolfram
The most common complication of silicone breast implants is capsular contracture (massive scar formation around the implant). We postulate that capsular contracture is always a sequel to inflammatory processes, with both innate and adaptive immune mechanisms participating. In general, fibroblasts and macrophages have been used as cell types to evaluate in vitro the biocompatibility of breast implant surfaces. Moreover, also T cells have been found at the implant site at the initial stage of fibrous capsule formation...
2018: PloS One
https://www.readbyqxmd.com/read/29389705/preventive-effect-of-synthetic-tryptophan-metabolite-on-silicone-breast-implant-induced-capsule-formation
#10
Shin Hyuk Kang, Suk Yoon Jang, Jeong Hyun Ryou, Woo Seob Kim, Han Koo Kim, Tae Hui Bae, Mi Kyung Kim
BACKGROUND: In the field of plastic surgery, capsular contracture after silicone breast implant surgery is a major clinical problem. This experimental study confirms that the synthetic tryptophan metabolite N-(3',4'-dimethoxycinnamonyl) anthranilic acid (Tranilast) reduces capsule formation and prevents capsular contracture. METHODS: Eighteen New Zealand white rabbits were divided into 2 groups. In the experimental group, implants were inserted into each rabbit, and oral synthetic tryptophan metabolite was administered daily at a dose of 5 mg/kg in 10 mL of saline...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29378017/plasma-activation-of-a-breast-implant-shell-in-conjunction-with-antibacterial-irrigants-enhances-antibacterial-activity
#11
Yoav Barnea, Dennis C Hammond, Yuval Geffen, Shiri Navon-Venezia, Keren Goldberg
Background: Infection and capsular contracture are two of the most significant complications of breast-implant surgery. Both complications are associated with bacterial contamination of the implant surface. Plasma activation of the surface of a silicone breast implant changes its surface properties from water repelling (hydrophobic) to water absorbing (hydrophilic), thus making it possible for antibacterial irrigants to temporarily adsorb onto the implant surface. Objective: To support our hypothesis that by changing the surface properties we could render antibacterial irrigation more effective in inhibiting bacterial growth on a breast implant shell...
January 25, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29176413/mentor-contour-profile-gel-implants-clinical-outcomes-at-10-years
#12
MULTICENTER STUDY
Dennis C Hammond, John W Canady, Tim R Love, Roger N Wixtrom, David A Caplin
BACKGROUND: Contour Profile Gel/MemoryShape breast implants consist of a textured silicone elastomer shell filled with silicone gel. The objective of this clinical study was to assess the safety and effectiveness of Contour Profile Gel/MemoryShape breast implants in women who were undergoing primary breast augmentation, primary breast reconstruction, or revision surgery (revision-augmentation or revision-reconstruction). METHODS: This was a prospective, open-label, multicenter clinical study involving Contour Profile Gel/MemoryShape breast implants in 955 female subjects, including 572 primary augmentation, 124 revision-augmentation, 190 primary reconstruction, and 69 revision-reconstruction subjects...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29166315/poly-implants-prosth%C3%A3-se-breast-implants-a-case-series-and-review-of-the-literature
#13
Doron Klein, Eran Hadad, Itay Wiser, Omer Wolf, Ortal Itzhaki Shapira, Shir Fucks, Lior Heller
BACKGROUND: Silicone breast implants from the French manufacturer Poly Implants Prosthèse (PIP) were recalled from the European market after the French regulator has revealed the implants contain non-medical-grade silicone filler. In December 2011, following a large increase in reported rupture rate and a possible cancer risk, the French Ministry of Health recommended consideration of the PIP explantation, regardless of their condition. In 2012, the Israel Ministry of Health recommended to replace the implants only upon suspected implant rupture...
January 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29040364/preliminary-3-year-evaluation-of-experience-with-silksurface-and-velvetsurface-motiva-silicone-breast-implants-a-single-center-experience-with-5813-consecutive-breast-augmentation-cases
#14
Marcos Sforza, Renato Zaccheddu, Angelo Alleruzzo, Adriano Seno, Domenico Mileto, Arnaldo Paganelli, Hassan Sulaiman, Michael Payne, Lajos Maurovich-Horvat
Background: Silicone breast implants have been in use for breast augmentation for more than 50 years, but technological innovation has been lacking in implant design until recently. Objectives: This study was designed to evaluate the complication and reoperation rates following breast augmentation utilizing the Motiva silicone breast implants. Methods: This retrospective study evaluated the safety of Motiva implants in 5813 consecutive cases of breast augmentation...
May 15, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040345/eight-year-safety-data-for-round-and-anatomical-silicone-gel-breast-implants
#15
Franck Duteille, Pierre Perrot, Marie-Hélène Bacheley, Sharon Stewart
Background: The safety and efficacy of all medical devices, including breast implants, is important and consistent performance is best shown by undertaking long-term clinical and vigilance studies. Local complications such as capsular contracture and rupture are risks often associated with breast implant surgery. Objectives: The authors investigate and evaluate the safety and performance of Eurosilicone's (Eurosilicone S.A.S, Apt Cedex, France) Cristalline Paragel breast implants at 8 years postimplantation...
February 17, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28985836/a-meta-analysis-of-implant-based-breast-reconstruction-and-timing-of-adjuvant-radiation-therapy
#16
REVIEW
Joseph A Ricci, Sherise Epstein, Adeyiza O Momoh, Samuel J Lin, Dhruv Singhal, Bernard T Lee
BACKGROUND: Implant-based breast reconstruction is the most common type of reconstruction after postmastectomy radiation therapy (PMRT). The impact of the timing of PMRT to a tissue expander or permanent implant is not well understood. The purpose of this systematic review was to evaluate outcomes in implant-based reconstruction and the timing of PMRT. METHODS: A review of the English literature in the PubMed/MEDLINE database (2000-2016) was performed to identify all articles on implant-based breast reconstruction and PMRT...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28831345/characterization-of-the-capsule-surrounding-smooth-and-textured-tissue-expanders-and-correlation-with-contracture
#17
Erika Kuriyama, Hiroko Ochiai, Yoshikazu Inoue, Yoshiaki Sakamoto, Naoki Yamamoto, Toshiaki Utsumi, Kazuo Kishi, Takayuki Okumoto, Akihiro Matsuura
Capsular contracture is a common complication after breast augmentation surgery. This study pathologically evaluated the soft-tissue response to surface modifications in both smooth and textured tissue expander prostheses. METHODS: Smooth tissue expanders and textured tissue expanders in 5 cases each were used for breast reconstruction after mastectomy. Histological samples were harvested from the capsules when the tissue expanders were replaced by silicone implants. Collagen orientation and cellular responses were assessed histologically...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28831335/subcutaneously-placed-breast-implants-after-a-skin-sparing-mastectomy-do-we-always-need-adm
#18
Apresh Singla, Animesh Singla, Eric Lai, David Caminer
Immediate breast reconstruction is an acceptable treatment option after mastectomy for prophylaxis of early breast cancer. Different options exist for implant placement, incision technique, patient suitability, and institutional experience. This article is a case series exploring the feasibility and outcomes of patients undergoing immediate breast reconstruction using skin-sparing mastectomy without mesh or acellular dermal matrix (ADM) and with a vertical inframammary incision. METHODS: A single-institution retrospective analysis was performed for all patients who underwent immediate single-stage reconstruction with subcutaneous silicon implants without ADM between 2009 and 2014 inclusive...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28715530/immunohistochemical-analysis-of-capsular-contracture-in-silicone-implant-rhinoplasty
#19
Woongsang Sunwoo, Hahnjin Jung, Dae Woo Kim, Hong Ryul Jin
No abstract text is available yet for this article.
September 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28710678/breast-magnetic-resonance-imaging-tips-for-the-diagnosis-of-silicone-induced-granuloma-of-a-breast-implant-capsule-sigbic
#20
REVIEW
Eduardo de Faria Castro Fleury, Ana Claudia Gianini, Veronica Ayres, Luciana C Ramalho, Rodrigo Oliveira Seleti, Decio Roveda
Complications resulting from the placement of silicone breast implants are becoming more frequent in our clinical practice. This is due to the increase in breast aesthetic surgeries at the beginning of the century, where breast augmentation using silicone implants was the main intervention performed. Generally, studies that discuss the complications of breast implants are restricted to reports of intra- or extra-capsular ruptures, contractures and haematomas. Currently, much importance has been given to anaplastic large cell lymphoma (ALCL) as a more severe complication related to silicone implants...
August 2017: Insights Into Imaging
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