keyword
https://read.qxmd.com/read/38510630/blood-biomarkers-for-traumatic-brain-injury-a-narrative-review-of-current-evidence
#21
REVIEW
Iftakher Hossain, Niklas Marklund, Endre Czeiter, Peter Hutchinson, Andras Buki
INTRODUCTION: A blood-based biomarker (BBBM) test could help to better stratify patients with traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary insults, predict outcomes, and monitor treatment effects and quality of care. RESEARCH QUESTION: What evidence is available for clinical applications of BBBMs in TBI and how to advance this field? MATERIAL AND METHODS: This narrative review discusses the potential clinical applications of core BBBMs in TBI...
2024: Brain Spine
https://read.qxmd.com/read/38510122/microbiome-depletion-prior-to-repeat-mild-tbi-differentially-alters-social-deficits-and-prefrontal-cortex-plasticity-in-adolescent-and-adult-rats
#22
JOURNAL ARTICLE
Marissa Sgro, Zoe N Kodila, Crystal Li, Irena Carmichael, Samantha Warren, Amy C Reichelt, Glenn R Yamakawa, Richelle Mychasiuk
Although aging, repeat mild traumatic brain injury (RmTBI), and microbiome modifications independently change social behavior, there has been no investigation into their cumulative effects on social behavior and neuroplasticity within the prefrontal cortex. Therefore, we examined how microbiome depletion prior to RmTBI affected social behavior and neuroplasticity in adolescent and adult rats. Play, temperament analysis, elevated plus maze, and the hot/cold plate assessed socio-emotional function. Analyses of perineuronal nets (PNNs) and parvalbumin (PV) interneurons was completed...
April 19, 2024: IScience
https://read.qxmd.com/read/38509046/prolonged-hourly-neurologic-examinations-are-associated-with-increased-delirium-and-no-discernible-benefit-in-mild-moderate-geriatric-traumatic-brain-injury
#23
JOURNAL ARTICLE
Ricardo Alejandro Fonseca Ruiz, Melissa Canas, Leonardo Diaz, Jose Alejandro Aldana, Hussain Afzal, Alejandro De Filippis Falcon, Drew Del Toro, Aaron Day, Jennifer McCarthy, Kristin Stansfield, Grant V Bochicchio, Grace Niziolek, Lindsay M Kranker, Matthew R Rosengart, Mark Hoofnagle, Jennifer Leonard
BACKGROUND: Serial neurologic examinations (NE) are routinely recommended in the ICU within the first 24 hours following a TBI. There are currently no widely accepted guidelines for the frequency of NE. Disruptions to the sleep-wake cycles increase the delirium rate. We aimed to evaluate whether there is a correlation between prolonged Q1-NE and development of delirium and to determine if this practice reduces the likelihood of missing the detection of a process requiring emergent intervention...
March 21, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38506428/trajectories-of-fatigue-and-related-outcomes-following-mild-acquired-brain-injury-a-multivariate-latent-class-growth-analysis
#24
JOURNAL ARTICLE
Tom Smejka, Daan Verberne, Jan Schepers, Claire Wolfs, Vera Schepers, Rudolf Ponds, Caroline Van Heugten
OBJECTIVE: Fatigue is a common symptom following acquired brain injury although the severity and course differs for many individuals. This longitudinal study aimed to identify latent trajectory classes of fatigue and associated outcomes following mild brain injury. METHODS: 204 adults with mild traumatic brain injury (159; 78%) or minor stroke (45; 22%) were assessed 4 times over 1 year. Subjective measures of fatigue, anxiety, depression, cognitive complaints and societal participation were collected...
March 20, 2024: Journal of Rehabilitation Medicine
https://read.qxmd.com/read/38505457/concussions-a-review-of-physiological-changes-and-long-term-sequelae
#25
REVIEW
Hemangi Patel, Sneha Polam, Roody Joseph
A concussion is a type of mild traumatic brain injury (mTBI). It is prevalent among athletes across a wide variety of sports. The exact mechanism of a concussion is unknown, but it is currently accepted that the acceleration and deceleration of the brain is the insult causing disturbances in activity. The most common symptoms of concussions include but are not limited to dizziness, nausea, vomiting, and headaches. With repetitive concussive injuries, athletes can experience permanent changes such as chronic traumatic encephalopathy (gradual degeneration of brain tissue), which can lead to personality changes and memory deficits...
February 2024: Curēus
https://read.qxmd.com/read/38504797/concussion-is-a-temporary-disability-rethinking-mild-traumatic-brain-injury-in-sports-medicine
#26
JOURNAL ARTICLE
Zachary W Bevilacqua
No abstract text is available yet for this article.
2024: Frontiers in Neurology
https://read.qxmd.com/read/38500020/time-to-recovery-and-its-predictors-following-traumatic-injuries-among-injured-victims-in-dessie-comprehensive-specialized-hospital-north-east-of-ethiopia-2022-a-retrospective-follow-up-study
#27
JOURNAL ARTICLE
Lehulu Tilahun, Mulusew Zeleke, Birhanu Desu, Kirubel Dagnew, Aytenew Nega, Endalk Birrie, Nathan Estifanos, Akele Tegegne, Asresu Feleke
BACKGROUND: Injuries are an extremely important public health problem worldwide. Despite being largely preventable and despite government efforts, injuries continue to be a major public health issue. Thus, the study tends to evaluate the time to recovery and its predictors for traumatic injuries. METHODS: A hospital-based retrospective follow-up study was used. A total of 329 medical charts were actually reviewed. Traumatic injury victims from January 1, 2018-December 31, 2022 were included, and a simple random sampling technique was utilized...
March 18, 2024: BMC Emergency Medicine
https://read.qxmd.com/read/38499578/reduced-influence-of-perceptual-context-in-mild-traumatic-brain-injury-is-not-an-illusion
#28
JOURNAL ARTICLE
A Sidhu, L Uiga, B Langley, R S W Masters
Perceptual grouping is impaired following mild traumatic brain injury (mTBI). This may affect visual size perception, a process influenced by perceptual grouping abilities. We conducted two experiments to evaluate visual size perception in people with self-reported history of mTBI, using two different size-contrast illusions: the Ebbinghaus Illusion (Experiment 1) and the Müller-Lyer illusion (Experiment 2). In Experiment 1, individuals with mTBI and healthy controls were asked to compare the size of two target circles that were either the same size or different sizes...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38499015/safety-and-efficacy-of-continuous-subcutaneous-levodopa-carbidopa-infusion-nd0612-for-parkinson-s-disease-with-motor-fluctuations-boundless-a-phase-3-randomised-double-blind-double-dummy-multicentre-trial
#29
JOURNAL ARTICLE
Alberto J Espay, Fabrizio Stocchi, Rajesh Pahwa, Alberto Albanese, Aaron Ellenbogen, Joaquim J Ferreira, Nir Giladi, Tanya Gurevich, Sharon Hassin-Baer, Jorge Hernandez-Vara, Stuart H Isaacson, Karl Kieburtz, Peter A LeWitt, Lydia Lopez-Manzanares, C Warren Olanow, Werner Poewe, Harini Sarva, Tami Yardeni, Liat Adar, Laurence Salin, Nelson Lopes, Nissim Sasson, Ryan Case, Olivier Rascol
BACKGROUND: Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion strategies might provide more consistent drug delivery and fewer motor fluctuations. We aimed to assess the safety and efficacy of a continuous 24 h/day subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) compared with oral immediate-release levodopa-carbidopa for the treatment of motor fluctuations in people with Parkinson's disease...
March 15, 2024: Lancet Neurology
https://read.qxmd.com/read/38497766/shaking-up-our-approach-the-need-for-characterization-and-optimization-of-preclinical-models-of-infant-abusive-head-trauma
#30
JOURNAL ARTICLE
Sydney Harris, Holly Chinnery, Bridgette D Semple, Richelle Mychasiuk
Traumatic brain injuries are a large societal and individual burden. In the first year of life, the vast majority of these injuries are the result of inflicted abusive events by a trusted caregiver. Abusive head trauma (AHT) in infants, formerly known as shaken baby syndrome, is the leading cause of inflicted mortality and morbidity in this population. In this review we address clinical diagnosis, symptoms, prognosis, and neuropathology of AHT, emphasizing the burden of repetitive AHT. Next, we consider existing animal models of AHT, and evaluate key features of an ideal model, highlighting important developmental milestones in children most vulnerable to AHT...
March 18, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38497739/visual-impairment-in-preclinical-models-of-mild-traumatic-brain-injury
#31
JOURNAL ARTICLE
Gabriella Orbach, Eva Melendes, Kaitlyn Warren, Jianhua Qiu, William Meehan, Rebekah Mannix, Fernanda Guilhaume Correa
Impairment in visual function is common after traumatic brain injury (TBI) in the clinical setting, a phenomenon that translates to pre-clinical animal models as well. Our laboratory's previous work has reported histological changes following weight-drop induced TBI in a rodent model including retinal ganglion cell (RGC) loss, decreased electroretinogram (ERG) evoked potential, optic nerve diameter reduction, induced inflammation and gliosis, and loss of myelin accompanied by markedly impaired visual acuity...
March 18, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38497571/valued-living-after-mild-traumatic-brain-injury-characteristics-and-relationship-with-outcomes
#32
JOURNAL ARTICLE
Josh W Faulkner, Diane Whiting, Alice Theadom, Deborah L Snell, Maree Roche, Suzanne Barker-Collo
Psychological factors are strong predictors of mild traumatic brain injury (mTBI) recovery, consequently, psychological interventions can form part of an individual's rehabilitation. This may include enhancing valued living (VL), an approach that is effective in severe and mixed acquired brain injury samples. This study aimed to characterize VL in mTBI and explore its relationship with mTBI and mental health outcomes. 56 participants with a mTBI completed self-report measures before engaging in a psychological intervention...
March 18, 2024: Neuropsychological Rehabilitation
https://read.qxmd.com/read/38497188/effects-of-transcranial-direct-current-stimulation-on-motor-and-cognitive-dysfunction-in-an-experimental-traumatic-brain-injury-model
#33
JOURNAL ARTICLE
Guven Akcay, Filiz Demirdogen, Tuba Gul, Ali Yilmaz, Dilcan Kotan, Esra Karakoc, Huseyin Emre Ozturk, Cagla Celik, Haydar Celik, Yavuz Erdem
AIM: To investigate the therapeutic and neuroprotective effects of transcranial direct current stimulation (tDCS) application on the traumatic brain injury (TBI)-induced glutamate and calcium excitotoxicity and loss of motor and cognitive functions. MATERIAL AND METHODS: Forty rats were equally divided in the sham, TBI, tDCS + TBI + tDCS, and TBI + tDCS groups. Mild TBI was induced by dropping a 450-g iron weight from a height of 1 m onto the skull of the rats. The tDCS + TBI + tDCS group was prophylactically administered 1 mA stimulation for 30 min for 7 days starting 5 days before inducing TBI...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38497117/executive-functioning-behavior-and-white-matter-microstructure-in-the-chronic-phase-after-pediatric-mild-traumatic-brain-injury-results-from-the-adolescent-brain-cognitive-development-study
#34
JOURNAL ARTICLE
Anja K Betz, Suheyla Cetin-Karayumak, Elena M Bonke, Johanna Seitz-Holland, Fan Zhang, Steve Pieper, Lauren J O'Donnell, Yorghos Tripodis, Yogesh Rathi, Martha E Shenton, Inga K Koerte
BACKGROUND: Mild traumatic brain injury (mTBI) is common in children. Long-term cognitive and behavioral outcomes as well as underlying structural brain alterations following pediatric mTBI have yet to be determined. In addition, the effect of age-at-injury on long-term outcomes is largely unknown. METHODS: Children with a history of mTBI ( n = 406; M age = 10 years, SD age = 0.63 years) who participated in the Adolescent Brain Cognitive Development (ABCD) study were matched (1:2 ratio) with typically developing children (TDC; n = 812) and orthopedic injury (OI) controls ( n = 812)...
March 18, 2024: Psychological Medicine
https://read.qxmd.com/read/38492795/hsa_circ_0018401-and-mir-127-5p-expressions-are-diagnostic-and-prognostic-markers-for-traumatic-brain-injury-tbi-in-trauma-patients
#35
JOURNAL ARTICLE
Xiancun Ma, Huimin Wang, Gaige Ye, Xin Zheng, Yu Wang
This study investigated the potentials of hsa_circ_0018401 and miR-127-5p in traumatic brain injury (TBI) diagnosis, stratification and outcome prediction. A retrospective analysis of clinical data and blood samples of n= 109 TBI patients was performed. Expression levels of hsa_circ_0018401 and miR-127-5p were measured using Real-time PCR. The diagnostic values, as well as the values in TBI stratification, of hsa_circ_0018401 and miR-127-5p were assessed by receiver operating characteristic analyses. The prognostic impacts were investigated for one-year endpoint events using multivariable Cox regression analyses and receiver operating characteristic analysis...
March 14, 2024: Neuroscience
https://read.qxmd.com/read/38489823/performance-of-the-impact-and-crash-prognostic-models-for-traumatic-brain-injury-in-a-contemporary-multicenter-cohort-a-track-tbi-study
#36
JOURNAL ARTICLE
John K Yue, Young M Lee, Xiaoying Sun, Thomas A van Essen, Mahmoud M Elguindy, Patrick J Belton, Dana Pisică, Ana Mikolic, Hansen Deng, John H Kanter, Michael A McCrea, Yelena G Bodien, Gabriela G Satris, Justin C Wong, Vardhaan S Ambati, Ramesh Grandhi, Ava M Puccio, Pratik Mukherjee, Alex B Valadka, Phiroz E Tarapore, Michael C Huang, Anthony M DiGiorgio, Amy J Markowitz, Esther L Yuh, David O Okonkwo, Ewout W Steyerberg, Hester F Lingsma, David K Menon, Andrew I R Maas, Sonia Jain, Geoffrey T Manley
OBJECTIVE: The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticosteroid Randomization After Significant Head Injury (CRASH) prognostic models for mortality and outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT and CRASH model performances in a contemporary cohort of US patients. METHODS: The prospective 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study (enrollment years 2014-2018) enrolled subjects aged ≥ 17 years who presented to level I trauma centers and received head CT within 24 hours of TBI...
March 15, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38485759/identifying-delay-in-glymphatic-clearance-of-labeled-protons-post-acute-head-trauma-utilizing-3d-asl-mri-arterial-spin-labeling-a-pilot-study
#37
JOURNAL ARTICLE
Charles R Joseph, Jubin Kang Lim, Bryce N Grohol, Marija Zivcevska, Joshua Lencke, Ethan Dean Rich, Connor James Arrasmith, Ian Shepherd Dorman, Bradley Waman Clark, Kim Love, Ben Ferry, Mark E Rolfs
This study correlated mild traumatic brain injury (mTBI) cognitive changes with ASL-MRI glymphatic clearance rates (GCRs) and recovery with GCR improvement. mTBI disrupts the blood brain barrier (BBB), reducing capillary mean transit time and GCRs. mTBI is clinically diagnosed utilizing history/examination findings with no physiologic biomarkers. 3D TGSE (turbo-gradient spin-echo) pulsed arterial spin-labeling 3T MRI with 7 long inversion times (TIs) assessed the signal clearance of labeled protons 2800-4000 ms postlabeling in bifrontal, bitemporal, and biparietal regions within 7 days of mTBI and once clinically cleared to resume activities...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38482939/identifying-the-cerebral-physiologic-response-to-aerobic-exercise-following-concussion-a-scoping-review
#38
JOURNAL ARTICLE
Dean M Cordingley, Alwyn Gomez, Michael Ellis, Frederick A Zeiler
OBJECTIVE: The purpose of this study was to identify the cerebral physiologic response to aerobic exercise in individuals with a symptomatic concussion, highlighting available knowledge and knowledge gaps in the literature. DESIGN: A systematic scoping review was conducted and reported in keeping with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. A search of EMBASE, MEDLINE, SCOPUS, BIOSIS, and Cochrane libraries was conducted on June 15, 2023 (from database inception)...
March 14, 2024: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38482818/imaging-findings-in-acute-traumatic-brain-injury-a-ninds-common-data-element-based-pictorial-review-and-analysis-of-over-4-000-admission-brain-ct-scans-from-the-center-tbi-study
#39
JOURNAL ARTICLE
Thijs Vande Vyvere, Dana Pisica, Guido Wilms, Lene Claes, Pieter Van Dyck, Annemiek Snoeckx, Luc van den Hauwe, Pim Pullens, Jan Verheyden, Max Wintermark, Sven Dekeyzer, Christine L Mac Donald, Andrew Maas, Paul Parizel
In 2010, the National Institute of Neurological Disorders and Stroke (NINDS) created a set of common data elements (CDEs) to help standardize the assessment and reporting of imaging findings in traumatic brain injury (TBI). However, as opposed to other standardized radiology reporting systems, a visual overview, and data to support the proposed standardized lexicon are lacking. We used over 4000 admission computerized tomography (CT) scans of patients with TBI from the CENTER-TBI study to develop an extensive pictorial overview of the NINDS TBI CDEs, with visual examples and background information on individual pathoanatomical lesion types, up to the level of supplemental and emerging information (e...
March 14, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38482809/metabolic-diaschisis-in-mild-traumatic-brain-injury
#40
JOURNAL ARTICLE
Robert Cole Boggs, Lora Talley Watts, Peter T Fox, Geoffrey D Clarke
Neurophysiological diaschisis presents in traumatic brain injury (TBI) as functional impairment distant to the lesion site caused by axonal neuroexcitation and deafferentation. Diaschisis studies in TBI models have evaluated acute phase functional and microstructural changes. Here, in vivo biochemical changes and cerebral blood flow (CBF) dynamics following TBI are studied with magnetic resonance. Behavioral assessments, magnetic resonance spectroscopy (MRS), and CBF measurements on rats followed cortical impact TBI...
March 14, 2024: Journal of Neurotrauma
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